SIMILAR PATTERNS OF AMINO ACIDS FOR 3RV5_D_DXCD92_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ar1 CYTOCHROME C OXIDASE

(Paracoccus
denitrificans) 		PF00116
(COX2)
PF02790
(COX2_TM) 		4 VAL B 231
GLU B 240
LYS B 168
PHE B 188
 None
 1.49A 3rv5C-1ar1B:
undetectable
3rv5D-1ar1B:
undetectable		 3rv5C-1ar1B:
14.34
3rv5D-1ar1B:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 VAL A 156
GLU A 168
LYS A 288
PHE A 323
 None
 1.22A 3rv5C-1gqjA:
0.4
3rv5D-1gqjA:
0.4		 3rv5C-1gqjA:
8.26
3rv5D-1gqjA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0w RIBONUCLEASE III

(Thermotoga
maritima) 		PF00035
(dsrm)
PF14622
(Ribonucleas_3_3) 		4 VAL A  97
GLU A 233
LYS A 159
PHE A 153
 None
 1.36A 3rv5C-1o0wA:
0.0
3rv5D-1o0wA:
0.0		 3rv5C-1o0wA:
17.06
3rv5D-1o0wA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0x METHIONINE
AMINOPEPTIDASE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24) 		4 VAL A  74
GLU A 212
LYS A  92
PHE A  91
 None
 1.30A 3rv5C-1o0xA:
0.7
3rv5D-1o0xA:
1.1		 3rv5C-1o0xA:
16.48
3rv5D-1o0xA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb8 WBPP

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		4 VAL A  24
GLU A 240
LYS A  38
PHE A  72
 None
 1.25A 3rv5C-1sb8A:
0.0
3rv5D-1sb8A:
0.0		 3rv5C-1sb8A:
13.65
3rv5D-1sb8A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t04 HUZAF ANTIBODY HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B  72
GLU B  10
LYS B  23
PHE B  29
 None
 1.47A 3rv5C-1t04B:
undetectable
3rv5D-1t04B:
undetectable		 3rv5C-1t04B:
14.16
3rv5D-1t04B:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys9 PROTEIN SPY1043

(Streptococcus
pyogenes) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 VAL A 118
GLU A 111
LYS A 138
PHE A 142
 None
 1.18A 3rv5C-1ys9A:
undetectable
3rv5D-1ys9A:
undetectable		 3rv5C-1ys9A:
16.27
3rv5D-1ys9A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		4 VAL A 154
GLU A  55
LYS A  52
LYS A   0
 None
 1.45A 3rv5C-1zy9A:
undetectable
3rv5D-1zy9A:
undetectable		 3rv5C-1zy9A:
9.58
3rv5D-1zy9A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		4 VAL 1 513
GLU 1 579
LYS 1 542
PHE 1 415
 None
None
SO4  1 648 (-3.2A)
None
 1.04A 3rv5C-2ijd1:
0.4
3rv5D-2ijd1:
0.4		 3rv5C-2ijd1:
9.31
3rv5D-2ijd1:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mhr MYOHEMERYTHRIN

(Themiste
hennahi) 		PF01814
(Hemerythrin) 		4 GLU A  12
LYS A  26
LYS A  30
PHE A  33
 None
None
None
SO4  A 124 (-4.5A)
 1.02A 3rv5C-2mhrA:
1.8
3rv5D-2mhrA:
1.9		 3rv5C-2mhrA:
28.35
3rv5D-2mhrA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC

(Mus musculus) 		PF00162
(PGK) 		4 VAL A  57
GLU A  78
LYS A  85
LYS A  90
 None
 1.48A 3rv5C-2paaA:
undetectable
3rv5D-2paaA:
undetectable		 3rv5C-2paaA:
12.06
3rv5D-2paaA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4v DIAMINE
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		4 VAL A  96
GLU A   8
LYS A 112
LYS A 108
 ACO  A 306 (-3.9A)
None
None
None
 1.38A 3rv5C-2q4vA:
0.0
3rv5D-2q4vA:
0.0		 3rv5C-2q4vA:
18.34
3rv5D-2q4vA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdg SUPERANTIGEN-LIKE
PROTEIN 11

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		4 VAL A  70
GLU A 127
LYS A 136
PHE A 135
 None
 1.41A 3rv5C-2rdgA:
undetectable
3rv5D-2rdgA:
undetectable		 3rv5C-2rdgA:
17.86
3rv5D-2rdgA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw2 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Aquifex
aeolicus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 VAL A 253
GLU A  71
LYS A 103
PHE A 109
 None
PO4  A 645 (-2.9A)
ATP  A 646 (-2.7A)
None
 1.46A 3rv5C-2yw2A:
undetectable
3rv5D-2yw2A:
undetectable		 3rv5C-2yw2A:
13.48
3rv5D-2yw2A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl9 SCAVENGER
MRNA-DECAPPING
ENZYME DCPS

(Homo sapiens) 		PF05652
(DcpS)
PF11969
(DcpS_C) 		4 VAL A  82
GLU A 185
LYS A  42
PHE A  44
 None
DD2  A 901 (-2.8A)
None
None
 1.49A 3rv5C-3bl9A:
undetectable
3rv5D-3bl9A:
undetectable		 3rv5C-3bl9A:
14.29
3rv5D-3bl9A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqy TOLUENE
1,2-DIOXYGENASE
SYSTEM FERREDOXIN
SUBUNIT

(Pseudomonas
putida) 		PF00355
(Rieske) 		4 VAL A  26
GLU A  95
LYS A  90
PHE A  87
 None
 1.38A 3rv5C-3dqyA:
undetectable
3rv5D-3dqyA:
undetectable		 3rv5C-3dqyA:
22.61
3rv5D-3dqyA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz8 MOUSE ANTI V3
ANTIBODY 7C8 FAB,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL A  71
GLU A  10
LYS A  23
PHE A  29
 None
 1.34A 3rv5C-3nz8A:
undetectable
3rv5D-3nz8A:
undetectable		 3rv5C-3nz8A:
16.59
3rv5D-3nz8A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqg HPY188I

(Helicobacter
pylori) 		no annotation 4 VAL A 121
GLU A  26
LYS A  73
PHE A  65
 None
 1.45A 3rv5C-3oqgA:
undetectable
3rv5D-3oqgA:
undetectable		 3rv5C-3oqgA:
20.35
3rv5D-3oqgA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvz UDP-N-ACETYLGLUCOSAM
INE 4,6-DEHYDRATASE

(Aliivibrio
fischeri) 		PF02719
(Polysacc_synt_2) 		4 VAL A  62
GLU A 239
LYS A  54
PHE A  88
 None
 1.40A 3rv5C-3pvzA:
undetectable
3rv5D-3pvzA:
undetectable		 3rv5C-3pvzA:
12.69
3rv5D-3pvzA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9w GTPASE ERA

(Aquifex
aeolicus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		4 VAL A   6
GLU A 177
LYS A  46
PHE A  56
 None
 1.31A 3rv5C-3r9wA:
0.0
3rv5D-3r9wA:
0.0		 3rv5C-3r9wA:
11.76
3rv5D-3r9wA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wva UPF0254 PROTEIN
MJ1251

(Methanocaldococcus
jannaschii) 		PF06787
(UPF0254) 		4 VAL A  46
GLU A  27
LYS A  32
PHE A 158
 None
 1.27A 3rv5C-3wvaA:
undetectable
3rv5D-3wvaA:
undetectable		 3rv5C-3wvaA:
20.23
3rv5D-3wvaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 VAL A 467
GLU A  87
LYS A  62
PHE A 249
 None
 1.32A 3rv5C-4b9yA:
undetectable
3rv5D-4b9yA:
undetectable		 3rv5C-4b9yA:
8.28
3rv5D-4b9yA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee9 ENDOGLUCANASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		4 VAL A   2
GLU A 321
LYS A 240
PHE A 315
 None
 1.39A 3rv5C-4ee9A:
undetectable
3rv5D-4ee9A:
undetectable		 3rv5C-4ee9A:
13.42
3rv5D-4ee9A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fem OUTER MEMBRANE
PROTEIN SUSE

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE) 		4 VAL A 237
GLU A 256
LYS A 221
PHE A 222
 None
None
ACX  A 401 (-2.9A)
None
 1.46A 3rv5C-4femA:
undetectable
3rv5D-4femA:
undetectable		 3rv5C-4femA:
16.56
3rv5D-4femA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8g TUMOR SUPPRESSOR
CANDIDATE 3

(Homo sapiens) 		PF04756
(OST3_OST6) 		4 VAL A  47
GLU A  17
LYS A  37
PHE A 113
 None
 1.15A 3rv5C-4m8gA:
undetectable
3rv5D-4m8gA:
undetectable		 3rv5C-4m8gA:
17.79
3rv5D-4m8gA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkn TRIOSEPHOSPHATE
ISOMERASE

(Chlamydomonas
reinhardtii) 		PF00121
(TIM) 		4 VAL A 163
GLU A 226
LYS A 253
PHE A   7
 None
 1.42A 3rv5C-4mknA:
undetectable
3rv5D-4mknA:
0.0		 3rv5C-4mknA:
15.56
3rv5D-4mknA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk6 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		4 VAL A 196
GLU A 276
LYS A 111
PHE A 112
 None
None
MLY  A 110 ( 2.9A)
None
 1.33A 3rv5C-4nk6A:
undetectable
3rv5D-4nk6A:
undetectable		 3rv5C-4nk6A:
11.34
3rv5D-4nk6A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pag PERIPLASMIC BINDING
PROTEIN

(Sulfurospirillum
deleyianum) 		PF01497
(Peripla_BP_2) 		4 VAL A 274
GLU A 236
LYS A 262
PHE A 258
 None
 1.06A 3rv5C-4pagA:
0.0
3rv5D-4pagA:
undetectable		 3rv5C-4pagA:
13.06
3rv5D-4pagA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF04551
(GcpE) 		4 VAL A  59
GLU A 232
LYS A 109
PHE A  88
 None
None
KCX  A 108 ( 3.3A)
None
 1.40A 3rv5C-4s38A:
undetectable
3rv5D-4s38A:
undetectable		 3rv5C-4s38A:
11.19
3rv5D-4s38A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ag9 GINGIPAIN R2

(Porphyromonas
gingivalis) 		PF03785
(Peptidase_C25_C) 		4 VAL A 702
GLU A 639
LYS A 732
PHE A 711
 None
 1.32A 3rv5C-5ag9A:
undetectable
3rv5D-5ag9A:
undetectable		 3rv5C-5ag9A:
18.79
3rv5D-5ag9A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		4 VAL A 240
GLU A 226
LYS A 254
PHE A 272
 None
 1.47A 3rv5C-5dtrA:
undetectable
3rv5D-5dtrA:
undetectable		 3rv5C-5dtrA:
12.57
3rv5D-5dtrA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxf MACROPHAGE
COLONY-STIMULATING
FACTOR 1

(Homo sapiens) 		PF05337
(CSF-1) 		4 VAL A  57
GLU A  96
LYS A 100
PHE A  37
 None
 1.45A 3rv5C-5lxfA:
undetectable
3rv5D-5lxfA:
undetectable		 3rv5C-5lxfA:
19.41
3rv5D-5lxfA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 4 VAL A 274
GLU A 252
LYS A 298
PHE A 303
 None
 1.25A 3rv5C-5m6gA:
undetectable
3rv5D-5m6gA:
undetectable		 3rv5C-5m6gA:
9.30
3rv5D-5m6gA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3) 		4 VAL B 365
GLU B 298
LYS B 269
PHE B 249
 None
 1.19A 3rv5C-5sy5B:
undetectable
3rv5D-5sy5B:
undetectable		 3rv5C-5sy5B:
12.63
3rv5D-5sy5B:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 120
GLU A 159
LYS A 152
PHE A 144
 None
 1.48A 3rv5C-5vo1A:
1.0
3rv5D-5vo1A:
1.5		 3rv5C-5vo1A:
18.14
3rv5D-5vo1A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Homo sapiens) 		no annotation 4 VAL A 102
LYS A  18
LYS A  16
PHE A  15
 None
 1.22A 3rv5C-5wp6A:
undetectable
3rv5D-5wp6A:
undetectable		 3rv5C-5wp6A:
undetectable
3rv5D-5wp6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1

(Homo sapiens) 		PF00400
(WD40)
PF00931
(NB-ARC) 		4 VAL A 323
GLU A 339
LYS A 348
PHE A 350
 None
 1.35A 3rv5C-5wveA:
undetectable
3rv5D-5wveA:
undetectable		 3rv5C-5wveA:
5.70
3rv5D-5wveA:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa2 CYSTEINE SYNTHASE

(Planctopirus
limnophila) 		PF00291
(PALP) 		4 VAL A 176
GLU A  69
LYS A 145
PHE A 232
 LLP  A  44 ( 4.0A)
None
None
None
 1.44A 3rv5C-5xa2A:
undetectable
3rv5D-5xa2A:
undetectable		 3rv5C-5xa2A:
16.56
3rv5D-5xa2A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 4 VAL C 619
GLU C 514
LYS C 470
PHE C 606
 None
 1.27A 3rv5C-5y6qC:
0.1
3rv5D-5y6qC:
0.0		 3rv5C-5y6qC:
undetectable
3rv5D-5y6qC:
undetectable