SIMILAR PATTERNS OF AMINO ACIDS FOR 3RV5_C_DXCC92

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 349
PHE A 120
PHE A 112
VAL A  83
 None
 1.44A 3rv5C-1bxzA:
undetectable
3rv5D-1bxzA:
undetectable		 3rv5C-1bxzA:
14.08
3rv5D-1bxzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqn DNA PRIMASE

(Escherichia
coli) 		PF08275
(Toprim_N)
PF10410
(DnaB_bind)
PF13155
(Toprim_2) 		4 VAL A 271
PHE A 206
PHE A 218
VAL A 215
 None
 1.33A 3rv5C-1eqnA:
0.3
3rv5D-1eqnA:
0.0		 3rv5C-1eqnA:
16.94
3rv5D-1eqnA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)

(Planomicrobium
okeanokoites) 		PF02980
(FokI_C)
PF02981
(FokI_N)
PF09254
(Endonuc-FokI_C)
PF16902
(Type2_restr_D3) 		4 VAL A 568
PHE A 572
PHE A 515
VAL A 512
 None
 1.46A 3rv5C-1fokA:
1.0
3rv5D-1fokA:
1.3		 3rv5C-1fokA:
13.53
3rv5D-1fokA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 VAL A 141
PHE A 156
PHE A 150
VAL A  39
 None
 1.30A 3rv5C-1hc7A:
undetectable
3rv5D-1hc7A:
undetectable		 3rv5C-1hc7A:
11.65
3rv5D-1hc7A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Thermotoga
maritima) 		PF01380
(SIS) 		4 VAL A 141
PHE A  22
PHE A  19
VAL A 178
 None
 1.14A 3rv5C-1j5xA:
undetectable
3rv5D-1j5xA:
undetectable		 3rv5C-1j5xA:
14.46
3rv5D-1j5xA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1

(Mus musculus) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		4 VAL A 467
PHE A 380
PHE A 381
VAL A 388
 None
 1.42A 3rv5C-1xhbA:
0.0
3rv5D-1xhbA:
0.0		 3rv5C-1xhbA:
11.04
3rv5D-1xhbA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z63 HELICASE OF THE
SNF2/RAD54 FAMILY

(Sulfolobus
solfataricus) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 VAL A 522
PHE A 520
PHE A 483
VAL A 560
 None
 1.37A 3rv5C-1z63A:
undetectable
3rv5D-1z63A:
2.2		 3rv5C-1z63A:
10.86
3rv5D-1z63A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		4 VAL A 195
PHE A 192
PHE A 215
VAL A 287
 None
 1.50A 3rv5C-2amgA:
undetectable
3rv5D-2amgA:
undetectable		 3rv5C-2amgA:
11.46
3rv5D-2amgA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Homo sapiens) 		PF00698
(Acyl_transf_1) 		4 VAL A 261
PHE A  31
PHE A 116
VAL A 288
 None
None
AE4  A1346 (-3.9A)
None
 1.40A 3rv5C-2c2nA:
0.2
3rv5D-2c2nA:
0.2		 3rv5C-2c2nA:
13.47
3rv5D-2c2nA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII

(Thermococcus
kodakarensis) 		PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 VAL A 498
PHE A  55
PHE A 526
VAL A 528
 None
 1.45A 3rv5C-2cw7A:
undetectable
3rv5D-2cw7A:
1.5		 3rv5C-2cw7A:
9.80
3rv5D-2cw7A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13407
(Peripla_BP_4) 		4 VAL A 155
PHE A 152
PHE A 222
VAL A 275
 None
 1.10A 3rv5C-2fn9A:
0.0
3rv5D-2fn9A:
undetectable		 3rv5C-2fn9A:
15.03
3rv5D-2fn9A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2guu ODCASE

(Plasmodium
vivax) 		PF00215
(OMPdecase) 		4 VAL A  62
PHE A 113
PHE A 114
VAL A 149
 None
 1.31A 3rv5C-2guuA:
undetectable
3rv5D-2guuA:
undetectable		 3rv5C-2guuA:
13.25
3rv5D-2guuA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h31 MULTIFUNCTIONAL
PROTEIN ADE2

(Homo sapiens) 		PF00731
(AIRC)
PF01259
(SAICAR_synt) 		4 VAL A 377
PHE A 386
PHE A 391
VAL A 268
 None
 1.42A 3rv5C-2h31A:
undetectable
3rv5D-2h31A:
undetectable		 3rv5C-2h31A:
13.68
3rv5D-2h31A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE

(Bacillus
halodurans) 		PF02608
(Bmp) 		4 VAL A   2
PHE A  62
PHE A  68
VAL A  40
 None
 1.38A 3rv5C-2hqbA:
undetectable
3rv5D-2hqbA:
undetectable		 3rv5C-2hqbA:
17.39
3rv5D-2hqbA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyk BETA-1,3-GLUCANASE

(Nocardiopsis
sp. F96) 		PF00722
(Glyco_hydro_16) 		4 VAL A 236
PHE A 168
PHE A 164
VAL A 137
 None
 1.25A 3rv5C-2hykA:
undetectable
3rv5D-2hykA:
undetectable		 3rv5C-2hykA:
15.92
3rv5D-2hykA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 VAL A   7
PHE A  78
PHE A  80
VAL A  34
 None
 1.42A 3rv5C-2i1jA:
0.7
3rv5D-2i1jA:
0.9		 3rv5C-2i1jA:
8.93
3rv5D-2i1jA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6i HD DOMAIN PROTEIN

(Enterococcus
faecalis) 		PF01966
(HD) 		4 VAL A  20
PHE A 194
PHE A  56
VAL A 242
 None
 1.19A 3rv5C-2o6iA:
0.0
3rv5D-2o6iA:
0.0		 3rv5C-2o6iA:
10.90
3rv5D-2o6iA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 VAL A 368
PHE A 379
PHE A 168
VAL A 318
 None
 1.46A 3rv5C-2qygA:
undetectable
3rv5D-2qygA:
0.0		 3rv5C-2qygA:
13.24
3rv5D-2qygA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raa PYRUVATE SYNTHASE
SUBUNIT PORC

(Thermotoga
maritima) 		PF01558
(POR) 		4 VAL A  89
PHE A 115
PHE A 106
VAL A 121
 None
 1.45A 3rv5C-2raaA:
0.0
3rv5D-2raaA:
0.0		 3rv5C-2raaA:
16.75
3rv5D-2raaA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg2 CHOLOYLGLYCINE
HYDROLASE

(Clostridium
perfringens) 		PF02275
(CBAH) 		4 VAL A 119
PHE A 105
PHE A  67
VAL A  54
 None
 1.33A 3rv5C-2rg2A:
0.4
3rv5D-2rg2A:
0.4		 3rv5C-2rg2A:
14.75
3rv5D-2rg2A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzx GREEN FLUORESCENT
PROTEIN

(Dendronephthya
sp. SSAL-2002) 		PF01353
(GFP) 		4 VAL A 118
PHE A 115
PHE A 114
VAL A  67
 None
 1.26A 3rv5C-2vzxA:
undetectable
3rv5D-2vzxA:
undetectable		 3rv5C-2vzxA:
17.57
3rv5D-2vzxA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa) 		PF02171
(Piwi) 		4 VAL A 532
PHE A 554
PHE A 582
VAL A 611
 None
None
None
SO4  A1939 (-3.9A)
 1.36A 3rv5C-2yhaA:
undetectable
3rv5D-2yhaA:
undetectable		 3rv5C-2yhaA:
14.92
3rv5D-2yhaA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa) 		PF02171
(Piwi) 		4 VAL A 532
PHE A 554
PHE A 582
VAL A 611
 None
None
None
SO4  A1939 ( 4.2A)
 1.40A 3rv5C-2yhbA:
undetectable
3rv5D-2yhbA:
undetectable		 3rv5C-2yhbA:
13.63
3rv5D-2yhbA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN

(Thermosynechococcus
vulcanus;
Thermosynechococcus
vulcanus) 		PF00421
(PSII)
PF00124
(Photo_RC) 		4 VAL D 287
PHE B 453
PHE B 451
VAL B 252
 DGD  B1058 (-4.2A)
None
CLA  B1012 (-3.6A)
CLA  B1012 (-4.5A)
 1.41A 3rv5C-3a0hD:
1.5
3rv5D-3a0hD:
undetectable		 3rv5C-3a0hD:
13.82
3rv5D-3a0hD:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3atg GLUCANASE

(Cellulosimicrobium
cellulans) 		PF00722
(Glyco_hydro_16) 		4 VAL A 232
PHE A 164
PHE A 160
VAL A 133
 None
 1.30A 3rv5C-3atgA:
undetectable
3rv5D-3atgA:
undetectable		 3rv5C-3atgA:
17.77
3rv5D-3atgA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		4 VAL A 368
PHE A 462
PHE A 461
VAL A 187
 None
 1.46A 3rv5C-3c6gA:
1.0
3rv5D-3c6gA:
0.9		 3rv5C-3c6gA:
11.69
3rv5D-3c6gA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN
POLYPROTEIN

(Senecavirus A;
Senecavirus A) 		no annotation
PF00073
(Rhv) 		4 VAL B 237
PHE A 108
PHE A 110
VAL A 193
 None
 1.06A 3rv5C-3cjiB:
undetectable
3rv5D-3cjiB:
undetectable		 3rv5C-3cjiB:
17.78
3rv5D-3cjiB:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		4 VAL A  51
PHE A 331
PHE A 329
VAL A 313
 None
 1.27A 3rv5C-3djdA:
undetectable
3rv5D-3djdA:
undetectable		 3rv5C-3djdA:
12.16
3rv5D-3djdA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894

(Bacteroides
uniformis) 		no annotation 4 VAL A  47
PHE A  19
PHE A 331
VAL A 309
 None
 0.80A 3rv5C-3dsmA:
undetectable
3rv5D-3dsmA:
undetectable		 3rv5C-3dsmA:
14.24
3rv5D-3dsmA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jqw COLH PROTEIN

(Hathewaya
histolytica) 		PF04151
(PPC) 		4 VAL A 979
PHE A 903
PHE A 901
VAL A 888
 None
 1.19A 3rv5C-3jqwA:
undetectable
3rv5D-3jqwA:
undetectable		 3rv5C-3jqwA:
21.95
3rv5D-3jqwA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0x PROTEIN TEN1

(Schizosaccharomyces
pombe) 		PF12658
(Ten1) 		4 VAL A  66
PHE A  23
PHE A   8
VAL A  95
 None
 1.21A 3rv5C-3k0xA:
undetectable
3rv5D-3k0xA:
undetectable		 3rv5C-3k0xA:
20.39
3rv5D-3k0xA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksm ABC-TYPE SUGAR
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Hahella
chejuensis) 		PF13407
(Peripla_BP_4) 		4 VAL A 190
PHE A 187
PHE A 258
VAL A 309
 None
 1.21A 3rv5C-3ksmA:
undetectable
3rv5D-3ksmA:
undetectable		 3rv5C-3ksmA:
14.50
3rv5D-3ksmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3b ES1 FAMILY PROTEIN

(Ehrlichia
chaffeensis) 		PF01965
(DJ-1_PfpI) 		4 VAL A  76
PHE A  40
PHE A 119
VAL A  98
 None
 1.34A 3rv5C-3l3bA:
undetectable
3rv5D-3l3bA:
undetectable		 3rv5C-3l3bA:
15.66
3rv5D-3l3bA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lib HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE

(Methanosarcina
mazei) 		PF02743
(dCache_1) 		4 VAL A 207
PHE A  57
PHE A 289
VAL A 179
 None
 1.22A 3rv5C-3libA:
undetectable
3rv5D-3libA:
undetectable		 3rv5C-3libA:
16.49
3rv5D-3libA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00158
(Sigma54_activat) 		4 VAL A 192
PHE A 226
PHE A 209
VAL A 254
 None
 1.39A 3rv5C-3m0eA:
undetectable
3rv5D-3m0eA:
undetectable		 3rv5C-3m0eA:
16.92
3rv5D-3m0eA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		4 VAL A 312
PHE A   8
PHE A 279
VAL A  11
 None
 1.39A 3rv5C-3m8yA:
undetectable
3rv5D-3m8yA:
undetectable		 3rv5C-3m8yA:
12.50
3rv5D-3m8yA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q08 CHLORITE DISMUTASE

(Dechloromonas
aromatica) 		PF06778
(Chlor_dismutase) 		4 VAL A 242
PHE A  77
PHE A  24
VAL A 146
 None
 1.17A 3rv5C-3q08A:
undetectable
3rv5D-3q08A:
undetectable		 3rv5C-3q08A:
16.67
3rv5D-3q08A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmq 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 2

(Burkholderia
pseudomallei) 		PF00793
(DAHP_synth_1) 		4 VAL A  82
PHE A  52
PHE A  20
VAL A 109
 None
 1.47A 3rv5C-3tmqA:
undetectable
3rv5D-3tmqA:
undetectable		 3rv5C-3tmqA:
15.64
3rv5D-3tmqA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui3 IMMUNOGLOBULIN
G-BINDING PROTEIN G,
VIRULENCE-ASSOCIATED
PROTEIN D

(Helicobacter
pylori;
Streptococcus
sp. 'group G') 		PF01378
(IgG_binding_B)
PF09827
(CRISPR_Cas2) 		4 VAL A 132
PHE A  64
PHE A  95
VAL A 115
 None
 1.41A 3rv5C-3ui3A:
undetectable
3rv5D-3ui3A:
undetectable		 3rv5C-3ui3A:
22.22
3rv5D-3ui3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE

(Brevibacillus
brevis) 		PF03306
(AAL_decarboxy) 		4 VAL A 190
PHE A  93
PHE A  39
VAL A 160
 None
None
None
GOL  A1260 ( 3.9A)
 1.35A 3rv5C-4bt6A:
undetectable
3rv5D-4bt6A:
undetectable		 3rv5C-4bt6A:
16.82
3rv5D-4bt6A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbv COME

(Streptococcus
pneumoniae) 		PF00072
(Response_reg)
PF04397
(LytTR) 		4 VAL A  71
PHE A  86
PHE A  56
VAL A   3
 None
 1.27A 3rv5C-4cbvA:
undetectable
3rv5D-4cbvA:
undetectable		 3rv5C-4cbvA:
17.27
3rv5D-4cbvA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		4 VAL A  89
PHE A 135
PHE A  63
VAL A  77
 None
 1.23A 3rv5C-4fixA:
undetectable
3rv5D-4fixA:
undetectable		 3rv5C-4fixA:
8.79
3rv5D-4fixA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963

(Streptomyces
coelicolor) 		no annotation 4 VAL B 291
PHE B 426
PHE B 154
VAL B 152
 None
 1.11A 3rv5C-4gt2B:
undetectable
3rv5D-4gt2B:
0.5		 3rv5C-4gt2B:
11.72
3rv5D-4gt2B:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 VAL A 294
PHE A 328
PHE A 329
VAL A 214
 None
 1.13A 3rv5C-4j3bA:
0.3
3rv5D-4j3bA:
0.2		 3rv5C-4j3bA:
7.56
3rv5D-4j3bA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		no annotation 4 VAL B 232
PHE B 146
PHE B 149
VAL B 186
 None
 1.36A 3rv5C-4lwoB:
undetectable
3rv5D-4lwoB:
undetectable		 3rv5C-4lwoB:
14.69
3rv5D-4lwoB:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhc NUCLEOPORIN NUP157

(Saccharomyces
cerevisiae) 		PF08801
(Nucleoporin_N) 		4 VAL A 353
PHE A 421
PHE A 434
VAL A 424
 None
 1.42A 3rv5C-4mhcA:
undetectable
3rv5D-4mhcA:
0.8		 3rv5C-4mhcA:
7.40
3rv5D-4mhcA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mld RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		PF00072
(Response_reg) 		4 VAL A  71
PHE A  86
PHE A  56
VAL A   3
 None
 1.37A 3rv5C-4mldA:
undetectable
3rv5D-4mldA:
undetectable		 3rv5C-4mldA:
17.36
3rv5D-4mldA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF01884
(PcrB) 		4 VAL A   6
PHE A  94
PHE A  95
VAL A 118
 None
None
PGE  A 302 (-3.7A)
None
 1.35A 3rv5C-4mm1A:
undetectable
3rv5D-4mm1A:
undetectable		 3rv5C-4mm1A:
19.40
3rv5D-4mm1A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvt E3 SUMO-PROTEIN
LIGASE PIAS3

(Homo sapiens) 		PF02891
(zf-MIZ)
PF14324
(PINIT) 		4 VAL A 260
PHE A 160
PHE A 162
VAL A 190
 None
 1.44A 3rv5C-4mvtA:
undetectable
3rv5D-4mvtA:
undetectable		 3rv5C-4mvtA:
12.68
3rv5D-4mvtA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6

(Trypanosoma
brucei) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 VAL A 330
PHE A 323
PHE A 345
VAL A 428
 None
 1.37A 3rv5C-4nlbA:
undetectable
3rv5D-4nlbA:
undetectable		 3rv5C-4nlbA:
14.06
3rv5D-4nlbA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

(Sulfitobacter
sp. NAS-14.1) 		PF03480
(DctP) 		4 VAL A 327
PHE A 114
PHE A 112
VAL A 307
 None
 1.08A 3rv5C-4nx1A:
undetectable
3rv5D-4nx1A:
undetectable		 3rv5C-4nx1A:
13.84
3rv5D-4nx1A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM3

(Methanocaldococcus
jannaschii) 		PF03787
(RAMPs) 		4 VAL C 108
PHE C 159
PHE C 157
VAL C  40
 None
 1.14A 3rv5C-4qtsC:
undetectable
3rv5D-4qtsC:
undetectable		 3rv5C-4qtsC:
11.85
3rv5D-4qtsC:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rma EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 VAL A   7
PHE A  78
PHE A  80
VAL A  34
 None
 1.41A 3rv5C-4rmaA:
undetectable
3rv5D-4rmaA:
undetectable		 3rv5C-4rmaA:
16.96
3rv5D-4rmaA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rr5 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Synechocystis
sp. PCC 6803) 		PF00698
(Acyl_transf_1) 		4 VAL A 146
PHE A 191
PHE A 187
VAL A 183
 None
None
ACT  A 301 ( 4.6A)
None
 1.41A 3rv5C-4rr5A:
undetectable
3rv5D-4rr5A:
undetectable		 3rv5C-4rr5A:
14.73
3rv5D-4rr5A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud4 POLY(A) RNA
POLYMERASE PROTEIN
CID1

(Schizosaccharomyces
pombe) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		4 VAL A 290
PHE A 278
PHE A 276
VAL A 192
 None
 1.39A 3rv5C-4ud4A:
undetectable
3rv5D-4ud4A:
undetectable		 3rv5C-4ud4A:
13.70
3rv5D-4ud4A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yrh ALPHA-TUBULIN
N-ACETYLTRANSFERASE
1

(Danio rerio) 		PF05301
(Acetyltransf_16) 		4 VAL A  17
PHE A 136
PHE A 134
VAL A 115
 None
None
None
ACO  A 201 (-4.5A)
 1.15A 3rv5C-4yrhA:
undetectable
3rv5D-4yrhA:
undetectable		 3rv5C-4yrhA:
21.52
3rv5D-4yrhA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yrh ALPHA-TUBULIN
N-ACETYLTRANSFERASE
1

(Danio rerio) 		PF05301
(Acetyltransf_16) 		4 VAL A 115
PHE A 134
PHE A 136
VAL A  17
 ACO  A 201 (-4.5A)
None
None
None
 1.46A 3rv5C-4yrhA:
undetectable
3rv5D-4yrhA:
undetectable		 3rv5C-4yrhA:
21.52
3rv5D-4yrhA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdk CTP SYNTHASE

(Mycobacterium
tuberculosis) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 VAL A 101
PHE A 165
PHE A  13
VAL A 172
 None
 1.36A 3rv5C-4zdkA:
undetectable
3rv5D-4zdkA:
undetectable		 3rv5C-4zdkA:
9.25
3rv5D-4zdkA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8v POLYHEDRIN

(Cypovirus 5) 		no annotation 4 VAL A 114
PHE A 192
PHE A 127
VAL A 177
 None
 1.47A 3rv5C-5a8vA:
undetectable
3rv5D-5a8vA:
undetectable		 3rv5C-5a8vA:
17.70
3rv5D-5a8vA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6

(Mus musculus) 		PF01663
(Phosphodiest) 		4 VAL A 213
PHE A  34
PHE A 238
VAL A  28
 None
 1.03A 3rv5C-5egeA:
undetectable
3rv5D-5egeA:
undetectable		 3rv5C-5egeA:
11.42
3rv5D-5egeA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exc GREEN FLUORESCENT
PROTEIN

(Dendronephthya
sp. SSAL-2002) 		PF01353
(GFP) 		4 VAL I 118
PHE I 115
PHE I 114
VAL I  67
 None
 1.16A 3rv5C-5excI:
undetectable
3rv5D-5excI:
undetectable		 3rv5C-5excI:
18.01
3rv5D-5excI:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 VAL A 152
PHE A 379
PHE A 380
VAL A 417
 VAL  A 152 ( 0.6A)
PHE  A 379 ( 1.3A)
PHE  A 380 ( 1.3A)
VAL  A 417 ( 0.6A)
 1.27A 3rv5C-5gprA:
undetectable
3rv5D-5gprA:
undetectable		 3rv5C-5gprA:
9.96
3rv5D-5gprA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 VAL A 413
PHE A 389
PHE A 477
VAL A 446
 None
 1.12A 3rv5C-5iudA:
undetectable
3rv5D-5iudA:
undetectable		 3rv5C-5iudA:
7.57
3rv5D-5iudA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kj2 HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF08214
(HAT_KAT11) 		4 VAL A1326
PHE A1361
PHE A1373
VAL A1321
 None
 1.35A 3rv5C-5kj2A:
undetectable
3rv5D-5kj2A:
undetectable		 3rv5C-5kj2A:
11.78
3rv5D-5kj2A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li8 PUTATIVE CYTOCHROME
P450 126

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 VAL A  94
PHE A 246
PHE A 251
VAL A 176
 None
KKK  A 502 (-4.7A)
None
None
 1.48A 3rv5C-5li8A:
1.2
3rv5D-5li8A:
0.9		 3rv5C-5li8A:
11.92
3rv5D-5li8A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li8 PUTATIVE CYTOCHROME
P450 126

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 VAL A 225
PHE A 246
PHE A 251
VAL A 164
 None
KKK  A 502 (-4.7A)
None
None
 1.36A 3rv5C-5li8A:
1.2
3rv5D-5li8A:
0.9		 3rv5C-5li8A:
11.92
3rv5D-5li8A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		4 VAL A1326
PHE A1361
PHE A1373
VAL A1321
 None
 1.34A 3rv5C-5lkzA:
undetectable
3rv5D-5lkzA:
undetectable		 3rv5C-5lkzA:
9.52
3rv5D-5lkzA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF16654
(DAPDH_C) 		4 VAL A 302
PHE A 281
PHE A  63
VAL A  61
 None
 1.49A 3rv5C-5loaA:
undetectable
3rv5D-5loaA:
undetectable		 3rv5C-5loaA:
16.67
3rv5D-5loaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5map DTPA

(Streptomyces
lividans) 		PF04261
(Dyp_perox) 		4 VAL A 291
PHE A 426
PHE A 154
VAL A 152
 None
 1.12A 3rv5C-5mapA:
undetectable
3rv5D-5mapA:
0.5		 3rv5C-5mapA:
14.03
3rv5D-5mapA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7g CREB-BINDING PROTEIN

(Mus musculus) 		PF00439
(Bromodomain)
PF00569
(ZZ)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		4 VAL A1363
PHE A1398
PHE A1410
VAL A1358
 None
 1.34A 3rv5C-5u7gA:
undetectable
3rv5D-5u7gA:
undetectable		 3rv5C-5u7gA:
10.56
3rv5D-5u7gA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ud0 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Helicobacter
pylori) 		no annotation 4 VAL A  19
PHE A  22
PHE A  24
VAL A  65
 None
 1.24A 3rv5C-5ud0A:
undetectable
3rv5D-5ud0A:
undetectable		 3rv5C-5ud0A:
undetectable
3rv5D-5ud0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wua ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL
11,SUPERFOLDER GFP

(Mus musculus;
synthetic
construct) 		PF01007
(IRK) 		4 VAL A 138
PHE A 123
PHE A  86
VAL A 151
 None
 1.14A 3rv5C-5wuaA:
undetectable
3rv5D-5wuaA:
undetectable		 3rv5C-5wuaA:
8.04
3rv5D-5wuaA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 4 VAL A 479
PHE A 488
PHE A 507
VAL A 453
 None
 1.32A 3rv5C-5zl9A:
undetectable
3rv5D-5zl9A:
undetectable		 3rv5C-5zl9A:
undetectable
3rv5D-5zl9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg9 -

(-) 		no annotation 4 VAL A 572
PHE A 588
PHE A 601
VAL A 624
 None
 1.22A 3rv5C-6fg9A:
undetectable
3rv5D-6fg9A:
undetectable		 3rv5C-6fg9A:
undetectable
3rv5D-6fg9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
A, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 VAL a  75
PHE a 102
PHE a 104
VAL a  46
 None
 1.25A 3rv5C-6fkha:
undetectable
3rv5D-6fkha:
undetectable		 3rv5C-6fkha:
undetectable
3rv5D-6fkha:
undetectable