SIMILAR PATTERNS OF AMINO ACIDS FOR 3RV5_B_DXCB92

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1djp GLUTAMINASE-ASPARAGI
NASE

(Pseudomonas sp.
7A) 		PF00710
(Asparaginase) 		4 VAL A1013
VAL A1012
ARG A1058
LYS A1118
 None
 1.30A 3rv5A-1djpA:
0.0
3rv5B-1djpA:
0.0		 3rv5A-1djpA:
15.31
3rv5B-1djpA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 VAL A  27
VAL A  21
ARG A  20
LYS A 499
 None
 1.47A 3rv5A-1eu1A:
0.0
3rv5B-1eu1A:
0.0		 3rv5A-1eu1A:
8.23
3rv5B-1eu1A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 VAL A 571
VAL A 607
ARG A 611
LYS A 621
 None
 1.43A 3rv5A-1f4hA:
undetectable
3rv5B-1f4hA:
undetectable		 3rv5A-1f4hA:
6.82
3rv5B-1f4hA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iaw TYPE II RESTRICTION
ENZYME NAEI

(Lechevalieria
aerocolonigenes) 		PF09126
(NaeI) 		4 VAL A  92
VAL A  18
ARG A  17
LYS A 134
 None
 0.98A 3rv5A-1iawA:
0.4
3rv5B-1iawA:
undetectable		 3rv5A-1iawA:
14.92
3rv5B-1iawA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kut PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Thermotoga
maritima) 		PF01259
(SAICAR_synt) 		4 VAL A  85
VAL A 111
ARG A  87
LYS A 156
 None
 1.44A 3rv5A-1kutA:
undetectable
3rv5B-1kutA:
undetectable		 3rv5A-1kutA:
17.26
3rv5B-1kutA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la1 GROEL

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		4 VAL A 346
VAL A 369
ARG A 350
LYS A 188
 None
 1.26A 3rv5A-1la1A:
0.5
3rv5B-1la1A:
undetectable		 3rv5A-1la1A:
20.11
3rv5B-1la1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ld9 MHC CLASS I H-2LD
HEAVY CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 VAL A  25
VAL A  34
ARG A  35
LYS A  68
 None
 1.31A 3rv5A-1ld9A:
undetectable
3rv5B-1ld9A:
undetectable		 3rv5A-1ld9A:
14.77
3rv5B-1ld9A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 VAL A  77
VAL A 145
ARG A 144
LYS A 107
 None
 1.45A 3rv5A-1nl3A:
0.0
3rv5B-1nl3A:
0.0		 3rv5A-1nl3A:
7.94
3rv5B-1nl3A:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR

(Homo sapiens) 		PF13561
(adh_short_C2) 		4 VAL A 124
VAL A 128
LYS A 185
LYS A 181
 None
 1.25A 3rv5A-1w8dA:
undetectable
3rv5B-1w8dA:
undetectable		 3rv5A-1w8dA:
14.90
3rv5B-1w8dA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzz INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Mus musculus) 		PF08709
(Ins145_P3_rec) 		4 VAL A 177
VAL A 176
ARG A 170
LYS A 219
 None
None
GOL  A1001 (-4.8A)
None
 1.06A 3rv5A-1xzzA:
undetectable
3rv5B-1xzzA:
undetectable		 3rv5A-1xzzA:
16.37
3rv5B-1xzzA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ab4 TRNA PSEUDOURIDINE
SYNTHASE B

(Thermotoga
maritima) 		PF01472
(PUA)
PF01509
(TruB_N)
PF16198
(TruB_C_2) 		4 VAL A  20
VAL A  23
ARG A  24
LYS A   1
 None
None
U  B  15 ( 3.4A)
None
 0.61A 3rv5A-2ab4A:
0.0
3rv5B-2ab4A:
undetectable		 3rv5A-2ab4A:
13.92
3rv5B-2ab4A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m05 BETA-AMYLOID-LIKE
PROTEIN

(Caenorhabditis
elegans) 		PF12924
(APP_Cu_bd) 		4 VAL A 193
VAL A 173
ARG A 174
LYS A 169
 None
 1.49A 3rv5A-2m05A:
undetectable
3rv5B-2m05A:
undetectable		 3rv5A-2m05A:
20.00
3rv5B-2m05A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8r POLYPHOSPHATE KINASE

(Porphyromonas
gingivalis) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		4 VAL A 160
VAL A 182
ARG A 189
LYS A 212
 None
 1.21A 3rv5A-2o8rA:
0.6
3rv5B-2o8rA:
0.5		 3rv5A-2o8rA:
9.21
3rv5B-2o8rA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9r ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF01835
(A2M_N) 		4 VAL A 183
VAL A 184
ARG A 191
LYS A 103
 None
 1.43A 3rv5A-2p9rA:
undetectable
3rv5B-2p9rA:
undetectable		 3rv5A-2p9rA:
19.23
3rv5B-2p9rA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		4 VAL A  32
VAL A  33
ARG A  34
LYS A 107
 None
ATP  A 381 (-4.1A)
None
None
 1.47A 3rv5A-2phkA:
0.0
3rv5B-2phkA:
0.0		 3rv5A-2phkA:
15.05
3rv5B-2phkA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE

(Dictyostelium
discoideum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 VAL A 166
VAL A 165
ARG A 187
LYS A  92
 None
 1.25A 3rv5A-2uuuA:
0.0
3rv5B-2uuuA:
undetectable		 3rv5A-2uuuA:
10.76
3rv5B-2uuuA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z51 NIFU-LIKE PROTEIN 2,
CHLOROPLAST

(Arabidopsis
thaliana) 		PF01106
(NifU) 		4 VAL A  36
VAL A  37
ARG A  38
LYS A  56
 None
 1.41A 3rv5A-2z51A:
undetectable
3rv5B-2z51A:
undetectable		 3rv5A-2z51A:
23.81
3rv5B-2z51A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ap1 PROTEIN-TYROSINE
SULFOTRANSFERASE 2

(Homo sapiens) 		PF13469
(Sulfotransfer_3) 		4 VAL A 154
VAL A  94
ARG A 153
LYS A 250
 None
 1.21A 3rv5A-3ap1A:
undetectable
3rv5B-3ap1A:
0.0		 3rv5A-3ap1A:
12.69
3rv5B-3ap1A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		4 VAL A 395
VAL A 364
ARG A 362
LYS A 319
 None
 1.27A 3rv5A-3c0kA:
undetectable
3rv5B-3c0kA:
undetectable		 3rv5A-3c0kA:
14.16
3rv5B-3c0kA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ery H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN

(Homo sapiens) 		PF00129
(MHC_I) 		4 VAL A  25
VAL A  34
ARG A  35
LYS A  68
 None
 1.44A 3rv5A-3eryA:
undetectable
3rv5B-3eryA:
undetectable		 3rv5A-3eryA:
16.00
3rv5B-3eryA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE

(Nitrosospira
multiformis) 		PF00365
(PFK) 		4 VAL A 311
VAL A  17
ARG A 303
LYS A 161
 None
 1.42A 3rv5A-3hnoA:
undetectable
3rv5B-3hnoA:
undetectable		 3rv5A-3hnoA:
13.01
3rv5B-3hnoA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrr INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 3

(Mus musculus) 		PF08709
(Ins145_P3_rec) 		4 VAL A 178
VAL A 177
ARG A 171
LYS A 220
 None
 1.14A 3rv5A-3jrrA:
undetectable
3rv5B-3jrrA:
undetectable		 3rv5A-3jrrA:
14.64
3rv5B-3jrrA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 VAL A 300
VAL A 322
ARG A 324
LYS A 213
 None
 1.32A 3rv5A-3k92A:
undetectable
3rv5B-3k92A:
0.4		 3rv5A-3k92A:
11.48
3rv5B-3k92A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oes GTPASE RHEBL1

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A  87
VAL A 129
ARG A 127
LYS A 136
 None
 1.45A 3rv5A-3oesA:
undetectable
3rv5B-3oesA:
undetectable		 3rv5A-3oesA:
18.91
3rv5B-3oesA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 VAL B 107
VAL B 106
ARG B  73
LYS B 137
 None
 1.18A 3rv5A-3ohmB:
4.1
3rv5B-3ohmB:
4.0		 3rv5A-3ohmB:
7.29
3rv5B-3ohmB:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oy2 GLYCOSYLTRANSFERASE
B736L

(Paramecium
bursaria
Chlorella virus
NY2A) 		no annotation 4 VAL A 343
VAL A 347
ARG A 208
LYS A 254
 None
 1.45A 3rv5A-3oy2A:
0.0
3rv5B-3oy2A:
undetectable		 3rv5A-3oy2A:
13.91
3rv5B-3oy2A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozq SERPIN48

(Tenebrio
molitor) 		PF00079
(Serpin) 		4 VAL A 322
VAL A 176
ARG A 175
LYS A 293
 None
 1.33A 3rv5A-3ozqA:
undetectable
3rv5B-3ozqA:
undetectable		 3rv5A-3ozqA:
14.24
3rv5B-3ozqA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pd7 DNA TOPOISOMERASE
2-BINDING PROTEIN 1

(Homo sapiens) 		PF00533
(BRCT) 		4 VAL A 909
VAL A 942
ARG A 935
LYS A 914
 None
 1.50A 3rv5A-3pd7A:
undetectable
3rv5B-3pd7A:
undetectable		 3rv5A-3pd7A:
19.09
3rv5B-3pd7A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqv RCL1 PROTEIN

(Kluyveromyces
lactis) 		PF01137
(RTC)
PF05189
(RTC_insert) 		4 VAL A 145
ARG A 146
LYS A 110
LYS A 112
 None
 1.33A 3rv5A-3pqvA:
undetectable
3rv5B-3pqvA:
undetectable		 3rv5A-3pqvA:
12.24
3rv5B-3pqvA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8s INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Rattus
norvegicus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 VAL A 177
VAL A 176
ARG A 170
LYS A 219
 None
 1.27A 3rv5A-3t8sA:
undetectable
3rv5B-3t8sA:
undetectable		 3rv5A-3t8sA:
8.03
3rv5B-3t8sA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubr CYTOCHROME C-552

(Shewanella
oneidensis) 		PF02335
(Cytochrom_C552) 		4 VAL A  95
VAL A  98
ARG A  99
LYS A 143
 None
HEC  A 471 ( 4.7A)
None
None
 1.17A 3rv5A-3ubrA:
undetectable
3rv5B-3ubrA:
undetectable		 3rv5A-3ubrA:
13.85
3rv5B-3ubrA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE

(Xenopus laevis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 VAL A 192
ARG A 179
LYS A 133
LYS A 136
 None
 1.33A 3rv5A-3w0lA:
undetectable
3rv5B-3w0lA:
undetectable		 3rv5A-3w0lA:
9.61
3rv5B-3w0lA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 VAL A 159
VAL A 162
ARG A 163
LYS A 178
 None
 0.85A 3rv5A-4c9mA:
1.7
3rv5B-4c9mA:
1.4		 3rv5A-4c9mA:
11.90
3rv5B-4c9mA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 VAL B 107
VAL B 106
ARG B  73
LYS B 137
 None
 1.17A 3rv5A-4gnkB:
4.5
3rv5B-4gnkB:
1.6		 3rv5A-4gnkB:
5.87
3rv5B-4gnkB:
5.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Francisella
tularensis) 		PF06026
(Rib_5-P_isom_A) 		4 VAL A  74
VAL A  55
LYS A  65
LYS A  67
 None
 1.39A 3rv5A-4io1A:
undetectable
3rv5B-4io1A:
undetectable		 3rv5A-4io1A:
19.55
3rv5B-4io1A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo8 M157

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 VAL A 276
VAL A 205
ARG A 286
LYS A 255
 None
 1.48A 3rv5A-4jo8A:
undetectable
3rv5B-4jo8A:
undetectable		 3rv5A-4jo8A:
14.05
3rv5B-4jo8A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4p ACYLNEURAMINATE
LYASE

(Mycoplasma
synoviae) 		PF00701
(DHDPS) 		4 VAL A  37
VAL A  77
ARG A  76
LYS A 102
 None
 1.41A 3rv5A-4n4pA:
undetectable
3rv5B-4n4pA:
undetectable		 3rv5A-4n4pA:
20.40
3rv5B-4n4pA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I) 		4 VAL E  25
VAL E  34
ARG E  35
LYS E  68
 None
 1.42A 3rv5A-4nhuE:
undetectable
3rv5B-4nhuE:
undetectable		 3rv5A-4nhuE:
16.85
3rv5B-4nhuE:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txk PROTEIN-METHIONINE
SULFOXIDE OXIDASE
MICAL1

(Mus musculus) 		PF00307
(CH)
PF01494
(FAD_binding_3) 		4 VAL A 326
VAL A 325
ARG A 310
LYS A 300
 None
 1.49A 3rv5A-4txkA:
undetectable
3rv5B-4txkA:
undetectable		 3rv5A-4txkA:
11.80
3rv5B-4txkA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		4 VAL A 851
VAL A 854
ARG A 855
LYS A 790
 None
 0.99A 3rv5A-4w8yA:
undetectable
3rv5B-4w8yA:
undetectable		 3rv5A-4w8yA:
7.38
3rv5B-4w8yA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwv AMINOPEPTIDASE FROM
FAMILY M42

(Desulfurococcus
amylolyticus) 		PF05343
(Peptidase_M42) 		4 VAL A 106
VAL A 105
ARG A 116
LYS A 181
 None
 1.46A 3rv5A-4wwvA:
undetectable
3rv5B-4wwvA:
undetectable		 3rv5A-4wwvA:
14.11
3rv5B-4wwvA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9a TRIOSEPHOSPHATE
ISOMERASE

(Streptomyces
coelicolor) 		PF00121
(TIM) 		4 VAL A 253
VAL A 256
ARG A 257
LYS A  69
 None
 1.38A 3rv5A-4y9aA:
undetectable
3rv5B-4y9aA:
undetectable		 3rv5A-4y9aA:
16.48
3rv5B-4y9aA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e72 N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE

(Thermococcus
kodakarensis) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 VAL A 126
VAL A 127
ARG A 128
LYS A 106
 None
 1.49A 3rv5A-5e72A:
undetectable
3rv5B-5e72A:
undetectable		 3rv5A-5e72A:
13.53
3rv5B-5e72A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng7 EPOXIDE HYDROLASE

(metagenome) 		no annotation 4 VAL A  55
VAL A  54
ARG A  53
LYS A 120
 None
 1.26A 3rv5A-5ng7A:
undetectable
3rv5B-5ng7A:
undetectable		 3rv5A-5ng7A:
undetectable
3rv5B-5ng7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Mus musculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 VAL A 177
VAL A 176
ARG A 170
LYS A 219
 None
 1.13A 3rv5A-5xa1A:
undetectable
3rv5B-5xa1A:
undetectable		 3rv5A-5xa1A:
5.16
3rv5B-5xa1A:
5.16