SIMILAR PATTERNS OF AMINO ACIDS FOR 3RV5_A_DXCA92

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 LYS A 397
PHE A 545
PHE A 547
VAL A 392
 None
 1.33A 3rv5A-2fuqA:
0.1
3rv5B-2fuqA:
0.7		 3rv5A-2fuqA:
7.81
3rv5B-2fuqA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		4 LYS A  44
PHE A  47
PHE A  50
VAL A 195
 None
 1.28A 3rv5A-2i62A:
undetectable
3rv5B-2i62A:
undetectable		 3rv5A-2i62A:
15.73
3rv5B-2i62A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mxz L-ALANYL-D-GLUTAMATE
PEPTIDASE

(Escherichia
virus T5) 		PF13539
(Peptidase_M15_4) 		4 LYS A   4
PHE A   3
PHE A  74
VAL A  93
 None
 1.29A 3rv5A-2mxzA:
0.6
3rv5B-2mxzA:
undetectable		 3rv5A-2mxzA:
21.23
3rv5B-2mxzA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdt LEVANSUCRASE

(Bacillus
subtilis) 		PF02435
(Glyco_hydro_68) 		4 LYS A 137
PHE A 124
PHE A 107
VAL A 197
 None
 1.13A 3rv5A-2vdtA:
undetectable
3rv5B-2vdtA:
undetectable		 3rv5A-2vdtA:
12.59
3rv5B-2vdtA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 LYS A 635
PHE A 621
PHE A 657
VAL A 606
 None
 1.10A 3rv5A-3a24A:
undetectable
3rv5B-3a24A:
undetectable		 3rv5A-3a24A:
10.41
3rv5B-3a24A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxo N,N-DIMETHYLTRANSFER
ASE

(Streptomyces
venezuelae) 		PF13649
(Methyltransf_25) 		4 LYS A  98
PHE A  99
PHE A  60
VAL A  32
 None
 1.12A 3rv5A-3bxoA:
undetectable
3rv5B-3bxoA:
undetectable		 3rv5A-3bxoA:
17.18
3rv5B-3bxoA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0c DIHYDRODIPICOLINATE
SYNTHASE

(Oceanobacillus
iheyensis) 		PF00701
(DHDPS) 		4 LYS A   8
PHE A  10
PHE A 189
VAL A 181
 None
 1.08A 3rv5A-3d0cA:
0.0
3rv5B-3d0cA:
undetectable		 3rv5A-3d0cA:
16.39
3rv5B-3d0cA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9m P-AMINOBENZOATE
SYNTHETASE,
COMPONENT I

(Cytophaga
hutchinsonii) 		PF00425
(Chorismate_bind) 		4 LYS A 218
PHE A 219
PHE A  83
VAL A 118
 None
PGE  A 438 (-4.2A)
None
None
 1.18A 3rv5A-3h9mA:
0.0
3rv5B-3h9mA:
0.0		 3rv5A-3h9mA:
13.03
3rv5B-3h9mA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i12 D-ALANINE-D-ALANINE
LIGASE A

(Salmonella
enterica) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LYS A 217
PHE A 212
PHE A 214
VAL A 193
 None
 1.44A 3rv5A-3i12A:
0.0
3rv5B-3i12A:
0.0		 3rv5A-3i12A:
13.19
3rv5B-3i12A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooq AMIDOHYDROLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		4 LYS A 133
PHE A 134
PHE A 386
VAL A 375
 None
 1.24A 3rv5A-3ooqA:
undetectable
3rv5B-3ooqA:
undetectable		 3rv5A-3ooqA:
13.13
3rv5B-3ooqA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q08 CHLORITE DISMUTASE

(Dechloromonas
aromatica) 		PF06778
(Chlor_dismutase) 		4 LYS A  28
PHE A  27
PHE A  76
VAL A 146
 None
 1.28A 3rv5A-3q08A:
0.9
3rv5B-3q08A:
0.0		 3rv5A-3q08A:
16.67
3rv5B-3q08A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qjp PUTATIVE
UNCHARACTERIZED
PROTEIN PH0350

(Pyrococcus
horikoshii) 		PF01881
(Cas_Cas6) 		4 LYS A 189
PHE A 188
PHE A 207
VAL A 235
 G  R   5 ( 3.1A)
None
None
None
 1.38A 3rv5A-3qjpA:
0.0
3rv5B-3qjpA:
undetectable		 3rv5A-3qjpA:
14.88
3rv5B-3qjpA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 LYS A 756
PHE A 746
PHE A 796
VAL A 820
 None
 1.13A 3rv5A-4bedA:
0.5
3rv5B-4bedA:
0.2		 3rv5A-4bedA:
4.43
3rv5B-4bedA:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nc2 TOXIN B

(Clostridioides
difficile) 		PF01473
(CW_binding_1) 		4 LYS A  63
PHE A  62
PHE A 115
VAL A 106
 None
 1.32A 3rv5A-4nc2A:
undetectable
3rv5B-4nc2A:
undetectable		 3rv5A-4nc2A:
20.63
3rv5B-4nc2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvw GALECTIN

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		4 LYS A 112
PHE A 113
PHE A  65
VAL A  75
 None
 1.30A 3rv5A-4wvwA:
undetectable
3rv5B-4wvwA:
undetectable		 3rv5A-4wvwA:
16.44
3rv5B-4wvwA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9g ISOCITRATE LYASE

(Magnaporthe
oryzae) 		PF00463
(ICL) 		4 LYS A 382
PHE A 272
PHE A 317
VAL A 321
 None
 1.34A 3rv5A-5e9gA:
0.2
3rv5B-5e9gA:
1.2		 3rv5A-5e9gA:
8.99
3rv5B-5e9gA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejy MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00784
(MyTH4) 		4 LYS A 327
PHE A 326
PHE A 324
VAL A 303
 None
 1.24A 3rv5A-5ejyA:
0.3
3rv5B-5ejyA:
0.2		 3rv5A-5ejyA:
10.73
3rv5B-5ejyA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dw1 -

(-) 		no annotation 4 LYS E 215
PHE E 186
PHE E 212
VAL E 178
 None
 1.33A 3rv5A-6dw1E:
undetectable
3rv5B-6dw1E:
undetectable		 3rv5A-6dw1E:
undetectable
3rv5B-6dw1E:
undetectable