SIMILAR PATTERNS OF AMINO ACIDS FOR 3RUN_A_CCSA165

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		3 ASN A 286
ALA A 285
LYS A 235
 None
 0.90A 3runA-1a6dA:
0.0		 3runA-1a6dA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfv MONOCLONAL ANTIBODY
FV4155

(Mus musculus) 		PF07686
(V-set) 		3 ASN H  74
ALA H  75
LYS H  77
 None
 1.04A 3runA-1cfvH:
0.0		 3runA-1cfvH:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef5 RGL

(Mus musculus) 		PF00788
(RA) 		3 ASN A 715
ALA A 714
LYS A 674
 None
 0.90A 3runA-1ef5A:
0.0		 3runA-1ef5A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ASN A 592
ALA A 561
LYS A 593
 None
 0.72A 3runA-1fepA:
0.0		 3runA-1fepA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7c ELONGATION FACTOR
1-ALPHA

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 ASN A 377
ALA A 397
LYS A 376
 None
 0.97A 3runA-1g7cA:
0.0		 3runA-1g7cA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7z ADENOVIRUS FIBRE
PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		3 ASN A 142
ALA A 141
LYS A 155
 None
 0.91A 3runA-1h7zA:
0.0		 3runA-1h7zA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipk BETA-CONGLYCININ,
BETA CHAIN

(Glycine max) 		PF00190
(Cupin_1)
PF07883
(Cupin_2) 		3 ASN A 345
ALA A 342
LYS A 269
 None
 0.93A 3runA-1ipkA:
0.0		 3runA-1ipkA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		3 ASN A 912
ALA A1039
LYS A1035
 None
 0.99A 3runA-1k7yA:
0.0		 3runA-1k7yA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASN A 448
ALA A 359
LYS A 449
 None
 0.96A 3runA-1kcwA:
0.0		 3runA-1kcwA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kte THIOLTRANSFERASE

(Sus scrofa) 		PF00462
(Glutaredoxin) 		3 ASN A   6
ALA A   3
LYS A   1
 None
 0.91A 3runA-1kteA:
undetectable		 3runA-1kteA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		3 ASN A 248
ALA A 247
LYS A 249
 None
 1.03A 3runA-1lxyA:
undetectable		 3runA-1lxyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0v PROTEIN-TYROSINE
PHOSPHATASE YOPH

(Yersinia
pseudotuberculosis) 		PF09013
(YopH_N) 		3 ASN A  34
ALA A  33
LYS A  35
 None
 0.99A 3runA-1m0vA:
undetectable		 3runA-1m0vA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE

(Escherichia
coli) 		PF02965
(Met_synt_B12) 		3 ASN A 912
ALA A1039
LYS A1035
 None
 0.86A 3runA-1mskA:
undetectable		 3runA-1mskA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oqw FIMBRIAL PROTEIN

(Pseudomonas
aeruginosa) 		PF00114
(Pilin)
PF07963
(N_methyl) 		3 ASN A  80
ALA A  79
LYS A  81
 None
 0.95A 3runA-1oqwA:
undetectable		 3runA-1oqwA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q25 CATION-INDEPENDENT
MANNOSE 6-PHOSPHATE
RECEPTOR

(Bos taurus) 		PF00878
(CIMR) 		3 ASN A 172
ALA A 157
LYS A 153
 None
 0.59A 3runA-1q25A:
undetectable		 3runA-1q25A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF07732
(Cu-oxidase_3) 		3 ASN A  76
ALA A  10
LYS A  77
 None
 0.97A 3runA-1sddA:
undetectable		 3runA-1sddA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ

(Glycine max) 		PF00190
(Cupin_1) 		3 ASN A 488
ALA A 485
LYS A 412
 None
 0.94A 3runA-1uikA:
undetectable		 3runA-1uikA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw4 UPF3X

(Homo sapiens) 		PF03467
(Smg4_UPF3) 		3 ASN A 100
ALA A 139
LYS A  52
 None
 1.03A 3runA-1uw4A:
undetectable		 3runA-1uw4A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aym U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		3 ASN A   8
ALA A  81
LYS A  82
 None
 0.99A 3runA-2aymA:
undetectable		 3runA-2aymA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 ASN A1034
ALA A  14
LYS A  35
 None
 1.01A 3runA-2b5mA:
undetectable		 3runA-2b5mA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7h RETINOBLASTOMA-BINDI
NG PROTEIN 6,
ISOFORM 3

(Homo sapiens) 		PF08783
(DWNN) 		3 ASN A  55
ALA A  56
LYS A  59
 None
 0.97A 3runA-2c7hA:
undetectable		 3runA-2c7hA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy3 ALANINE RACEMASE

(Corynebacterium
glutamicum) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ASN A  16
ALA A  12
LYS A 233
 None
 1.03A 3runA-2dy3A:
undetectable		 3runA-2dy3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eaa 7S GLOBULIN-3

(Vigna angularis) 		PF00190
(Cupin_1) 		3 ASN A 360
ALA A 357
LYS A 285
 None
 1.03A 3runA-2eaaA:
undetectable		 3runA-2eaaA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		3 ASN A 310
ALA A 309
LYS A 257
 None
 0.92A 3runA-2et6A:
undetectable		 3runA-2et6A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ASN A 101
ALA A  47
LYS A 102
 None
 1.01A 3runA-2fymA:
undetectable		 3runA-2fymA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		3 ASN A 250
ALA A 249
LYS A 251
 None
 0.80A 3runA-2iu4A:
undetectable		 3runA-2iu4A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kvb CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Bos taurus) 		PF00878
(CIMR) 		3 ASN A 626
ALA A 613
LYS A 610
 None
 0.83A 3runA-2kvbA:
undetectable		 3runA-2kvbA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lcl TRANSCRIPTIONAL
ACTIVATOR RFAH

(Escherichia
coli) 		no annotation 3 ASN A 156
ALA A 137
LYS A 155
 None
 1.04A 3runA-2lclA:
undetectable		 3runA-2lclA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2msv MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		no annotation 3 ASN A 102
ALA A 134
LYS A  99
 None
 0.97A 3runA-2msvA:
undetectable		 3runA-2msvA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nef NEGATIVE FACTOR
(F-PROTEIN)

(Human
immunodeficiency
virus 1) 		PF00469
(F-protein) 		3 ASN A 205
ALA A 206
LYS A 204
 None
 0.70A 3runA-2nefA:
undetectable		 3runA-2nefA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o39 FIBER PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		3 ASN A 144
ALA A 143
LYS A 157
 None
 1.04A 3runA-2o39A:
undetectable		 3runA-2o39A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfv EXOCYST COMPLEX
COMPONENT EXO70

(Saccharomyces
cerevisiae) 		PF03081
(Exo70) 		3 ASN A 357
ALA A 356
LYS A 445
 None
 0.95A 3runA-2pfvA:
undetectable		 3runA-2pfvA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phl PHASEOLIN

(Phaseolus
vulgaris) 		PF00190
(Cupin_1) 		3 ASN A 328
ALA A 325
LYS A 259
 None
 0.94A 3runA-2phlA:
undetectable		 3runA-2phlA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py0 FIMBRIAL PROTEIN

(Pseudomonas
aeruginosa) 		PF00114
(Pilin) 		3 ASN A  80
ALA A  79
LYS A  81
 None
 1.04A 3runA-2py0A:
undetectable		 3runA-2py0A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw8 EUGENOL SYNTHASE 1

(Ocimum
basilicum) 		PF05368
(NmrA) 		3 ASN A 103
ALA A 101
LYS A  74
 None
 1.03A 3runA-2qw8A:
undetectable		 3runA-2qw8A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yf0 MYOTUBULARIN-RELATED
PROTEIN 6

(Homo sapiens) 		PF06602
(Myotub-related) 		3 ASN A 150
ALA A 149
LYS A 154
 None
 0.79A 3runA-2yf0A:
undetectable		 3runA-2yf0A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 ASN A 494
ALA A 493
LYS A 495
 None
 0.97A 3runA-2yheA:
undetectable		 3runA-2yheA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjg LACTATE RACEMASE
APOPROTEIN

(Thermoanaerobacterium
thermosaccharolyticum) 		PF09861
(DUF2088) 		3 ASN A  94
ALA A  60
LYS A  63
 None
 0.57A 3runA-2yjgA:
undetectable		 3runA-2yjgA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zmf CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF01590
(GAF) 		3 ASN A 366
ALA A 392
LYS A 387
 None
 0.77A 3runA-2zmfA:
undetectable		 3runA-2zmfA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		3 ASN A 287
ALA A 279
LYS A 288
 None
 0.98A 3runA-3actA:
undetectable		 3runA-3actA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bnk FLAVOREDOXIN

(Methanosarcina
acetivorans) 		PF01613
(Flavin_Reduct) 		3 ASN A  24
ALA A  29
LYS A  28
 None
 0.99A 3runA-3bnkA:
undetectable		 3runA-3bnkA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdk SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
B

(Bacillus
subtilis) 		PF01144
(CoA_trans) 		3 ASN B  68
ALA B  69
LYS B  71
 None
 0.99A 3runA-3cdkB:
undetectable		 3runA-3cdkB:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnc FIBER PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		3 ASN A 172
ALA A 171
LYS A 185
 None
 0.93A 3runA-3cncA:
undetectable		 3runA-3cncA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6e ALANINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ASN A  21
ALA A  17
LYS A 244
 None
 0.97A 3runA-3e6eA:
undetectable		 3runA-3e6eA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehq OSTEOCLAST-STIMULATI
NG FACTOR 1

(Homo sapiens) 		PF00018
(SH3_1)
PF12796
(Ank_2) 		3 ASN A 137
ALA A 105
LYS A 138
 None
 0.98A 3runA-3ehqA:
undetectable		 3runA-3ehqA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzt OUTER CAPSID
GLYCOPROTEIN VP7

(Rotavirus A) 		PF00434
(VP7) 		3 ASN B 182
ALA B 181
LYS B 183
 None
None
CA  B 322 ( 4.5A)
 0.87A 3runA-3gztB:
undetectable		 3runA-3gztB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrm PROTEASOME ACTIVATOR
PROTEIN PA26

(Trypanosoma
brucei) 		PF02252
(PA28_beta) 		3 ASN O 104
ALA O 102
LYS O 100
 None
 1.00A 3runA-3jrmO:
undetectable		 3runA-3jrmO:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN

(Rhodobacter
sphaeroides) 		PF02126
(PTE) 		3 ASN A  74
ALA A  55
LYS A  75
 None
 0.95A 3runA-3k2gA:
undetectable		 3runA-3k2gA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l93 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Yersinia pestis) 		PF01467
(CTP_transf_like) 		3 ASN A  84
ALA A  83
LYS A   4
 None
 0.99A 3runA-3l93A:
undetectable		 3runA-3l93A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6u LYSR TYPE REGULATOR
OF TSAMBCD

(Comamonas
testosteroni) 		PF03466
(LysR_substrate) 		3 ASN A 250
ALA A 251
LYS A 253
 None
 0.90A 3runA-3n6uA:
undetectable		 3runA-3n6uA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE

(Escherichia
coli) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		3 ASN A 497
ALA A 536
LYS A 498
 None
None
ADP  A3001 (-2.9A)
 0.84A 3runA-3o98A:
undetectable		 3runA-3o98A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oh8 NUCLEOSIDE-DIPHOSPHA
TE SUGAR EPIMERASE
(SULA FAMILY)

(Corynebacterium
glutamicum) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		3 ASN A 372
ALA A 373
LYS A 329
 None
 0.85A 3runA-3oh8A:
undetectable		 3runA-3oh8A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op0 SIGNAL TRANSDUCTION
PROTEIN CBL-C

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		3 ASN A 291
ALA A 290
LYS A 292
 None
 0.95A 3runA-3op0A:
undetectable		 3runA-3op0A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf2 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		3 ASN A 421
ALA A 420
LYS A 450
 None
 0.95A 3runA-3pf2A:
undetectable		 3runA-3pf2A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrl SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
B

(Helicobacter
pylori) 		PF01144
(CoA_trans) 		3 ASN B  64
ALA B  65
LYS B  67
 None
 0.95A 3runA-3rrlB:
undetectable		 3runA-3rrlB:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7i ALLERGEN ARA H 1,
CLONE P41B

(Arachis
hypogaea) 		PF00190
(Cupin_1) 		3 ASN A 538
ALA A 535
LYS A 451
 None
 0.90A 3runA-3s7iA:
undetectable		 3runA-3s7iA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III) 		3 ASN B 749
ALA B 767
LYS B 748
 None
 1.04A 3runA-3thwB:
undetectable		 3runA-3thwB:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzg HYPOTHETICAL PROTEIN
BVU_2266

(Bacteroides
vulgatus) 		no annotation 3 ASN A 189
ALA A 188
LYS A  28
 None
 0.99A 3runA-3tzgA:
undetectable		 3runA-3tzgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7i FMN-DEPENDENT
NADH-AZOREDUCTASE 1

(Bacillus
anthracis) 		PF02525
(Flavodoxin_2) 		3 ASN A  93
ALA A  92
LYS A   3
 None
 1.04A 3runA-3u7iA:
undetectable		 3runA-3u7iA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vab DIAMINOPIMELATE
DECARBOXYLASE 1

(Brucella
melitensis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 ASN A 302
ALA A 340
LYS A 301
 None
None
EDO  A 424 ( 3.7A)
 0.98A 3runA-3vabA:
undetectable		 3runA-3vabA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 ASN A 473
ALA A 425
LYS A 428
 None
 0.66A 3runA-3zz1A:
undetectable		 3runA-3zz1A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acq ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 ASN A 566
ALA A 565
LYS A 567
 None
 0.89A 3runA-4acqA:
undetectable		 3runA-4acqA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		3 ASN A 109
ALA A  47
LYS A  48
 None
 0.96A 3runA-4am3A:
undetectable		 3runA-4am3A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ars HISTIDINE ACID
PHOSPHATASE

(Hafnia alvei) 		PF00328
(His_Phos_2) 		3 ASN A 298
ALA A  84
LYS A 299
 None
 1.01A 3runA-4arsA:
undetectable		 3runA-4arsA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6y BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		3 ASN A 214
ALA A 213
LYS A 215
 None
 1.01A 3runA-4c6yA:
undetectable		 3runA-4c6yA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 ASN A 605
ALA A 671
LYS A 608
 None
 0.96A 3runA-4d8mA:
undetectable		 3runA-4d8mA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dag FUSION GLYCOPROTEIN
F0

(Human
metapneumovirus) 		PF00523
(Fusion_gly) 		3 ASN A 313
ALA A 314
LYS A 312
 None
 0.92A 3runA-4dagA:
undetectable		 3runA-4dagA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Drosophila
melanogaster) 		PF01144
(CoA_trans) 		3 ASN A 361
ALA A 362
LYS A 364
 None
 1.00A 3runA-4kgbA:
undetectable		 3runA-4kgbA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4liy FIBER PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		3 ASN A 142
ALA A 141
LYS A 155
 None
 0.92A 3runA-4liyA:
undetectable		 3runA-4liyA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m00 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		3 ASN A 649
ALA A 576
LYS A 575
 CA  A 802 ( 4.7A)
None
None
 0.93A 3runA-4m00A:
undetectable		 3runA-4m00A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		3 ASN A 136
ALA A 135
LYS A 137
 None
 0.96A 3runA-4n7tA:
undetectable		 3runA-4n7tA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn2 PHD FINGER PROTEIN 6

(Homo sapiens) 		PF13771
(zf-HC5HC2H) 		3 ASN A 232
ALA A 233
LYS A 235
 None
 0.52A 3runA-4nn2A:
undetectable		 3runA-4nn2A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzk UNCHARACTERIZED
PROTEIN

([Eubacterium]
siraeum) 		PF14286
(DHHW) 		3 ASN A 308
ALA A 307
LYS A 309
 None
 0.85A 3runA-4nzkA:
undetectable		 3runA-4nzkA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcq TUBZ

(Clostridium
phage c-st) 		PF00091
(Tubulin) 		3 ASN A 139
ALA A  97
LYS A  60
 None
GDP  A 401 (-3.4A)
GDP  A 401 ( 4.5A)
 1.00A 3runA-4xcqA:
undetectable		 3runA-4xcqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuo ENDO-1,4-BETA-XYLANA
SE C

(Paenibacillus
barcinonensis) 		PF02018
(CBM_4_9) 		3 ASN A 108
ALA A 109
LYS A  90
 None
 0.64A 3runA-4xuoA:
undetectable		 3runA-4xuoA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xup ENDO-1,4-BETA-XYLANA
SE C

(Paenibacillus
barcinonensis) 		PF02018
(CBM_4_9) 		3 ASN A 108
ALA A 109
LYS A  90
 None
 0.63A 3runA-4xupA:
undetectable		 3runA-4xupA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4s EXTRACELLULAR HEME
ACQUISITION
HEMOPHORE HASA

(Yersinia
pseudotuberculosis) 		PF06438
(HasA) 		3 ASN A  99
ALA A 105
LYS A 107
 None
 1.01A 3runA-4y4sA:
undetectable		 3runA-4y4sA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)

(Homo sapiens) 		no annotation 3 ASN A 386
ALA A 385
LYS A 387
 None
None
NA  A 509 (-4.3A)
 0.95A 3runA-4z79A:
undetectable		 3runA-4z79A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)

(Homo sapiens) 		no annotation 3 ASN A 386
ALA A 385
LYS A 387
 None
 0.92A 3runA-4z8gA:
undetectable		 3runA-4z8gA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT

(Escherichia
coli) 		PF01555
(N6_N4_Mtase) 		3 ASN A 228
ALA A 229
LYS A 227
 None
 0.90A 3runA-4zcfA:
undetectable		 3runA-4zcfA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo4 DEPHOSPHO-COA KINASE

(Campylobacter
jejuni) 		PF01121
(CoaE) 		3 ASN A   3
ALA A 110
LYS A 109
 None
 0.99A 3runA-4zo4A:
undetectable		 3runA-4zo4A:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		3 ASN A 429
ALA A 426
LYS A 280
 None
 0.92A 3runA-5a2rA:
undetectable		 3runA-5a2rA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdd STRUCTURAL
POLYPROTEIN, VP2

(Israeli acute
paralysis virus) 		PF00073
(Rhv) 		3 ASN C 142
ALA C 141
LYS C 234
 None
 0.96A 3runA-5cddC:
undetectable		 3runA-5cddC:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Thermoproteus
uzoniensis) 		PF01063
(Aminotran_4) 		3 ASN A  84
ALA A  83
LYS A   2
 None
 0.93A 3runA-5ce8A:
undetectable		 3runA-5ce8A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efn HDAC6 PROTEIN

(Danio rerio) 		no annotation 3 ASN B 665
ALA B 649
LYS B 653
 None
 0.90A 3runA-5efnB:
undetectable		 3runA-5efnB:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0h HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		3 ASN A 665
ALA A 649
LYS A 653
 None
 0.87A 3runA-5g0hA:
undetectable		 3runA-5g0hA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		3 ASN A1510
ALA A1511
LYS A1512
 None
 1.00A 3runA-5i6hA:
undetectable		 3runA-5i6hA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcd CHITIN
ELICITOR-BINDING
PROTEIN

(Oryza sativa) 		PF01476
(LysM) 		3 ASN A  74
ALA A  73
LYS A  93
 None
 0.86A 3runA-5jcdA:
undetectable		 3runA-5jcdA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkq PFVFT1

(Plasmodium
falciparum) 		no annotation 3 ASN A  29
ALA A 301
LYS A  30
 None
 0.90A 3runA-5jkqA:
undetectable		 3runA-5jkqA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kx1 DESIGNED PEPTIDE
NC_CHHH_D1

(synthetic
construct) 		no annotation 3 ASN A  12
ALA A  11
LYS A  13
 None
 0.85A 3runA-5kx1A:
undetectable		 3runA-5kx1A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m41 NIGRITOXINE

(Vibrio
nigripulchritudo) 		no annotation 3 ASN A 417
ALA A 420
LYS A 414
 None
 1.00A 3runA-5m41A:
undetectable		 3runA-5m41A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mek CYTOSOLIC
SULFOTRANSFERASE 18

(Arabidopsis
thaliana) 		PF00685
(Sulfotransfer_1) 		3 ASN A 308
ALA A 292
LYS A 297
 EDO  A 402 (-4.5A)
EDO  A 402 (-3.9A)
None
 0.79A 3runA-5mekA:
undetectable		 3runA-5mekA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlk ACETYL-COA
CARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ASN A  86
ALA A  85
LYS A  14
 None
 0.93A 3runA-5mlkA:
undetectable		 3runA-5mlkA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 3 ASN A 447
ALA A 358
LYS A 448
 None
 0.97A 3runA-5n4lA:
undetectable		 3runA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 3 ASN A 445
ALA A 447
LYS A 449
 None
 0.93A 3runA-5ny0A:
undetectable		 3runA-5ny0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxi EARP

(Neisseria
meningitidis) 		no annotation 3 ASN A 178
ALA A 179
LYS A 177
 None
 0.99A 3runA-5wxiA:
undetectable		 3runA-5wxiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvn CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS2

(Enterococcus
faecalis) 		PF09827
(CRISPR_Cas2) 		3 ASN E  55
ALA E  54
LYS E  56
 None
 0.98A 3runA-5xvnE:
undetectable		 3runA-5xvnE:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 3 ASN A1347
ALA A1326
LYS A1332
 None
 0.83A 3runA-5xyaA:
1.1		 3runA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys9 ACYL-COENZYME A
OXIDASE 3

(Yarrowia
lipolytica) 		no annotation 3 ASN A 491
ALA A 490
LYS A 492
 None
 0.78A 3runA-5ys9A:
undetectable		 3runA-5ys9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
MBH13 NADH
DEHYDROGENASE
SUBUNIT

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation 		3 ASN M  65
ALA M  64
LYS H 381
 None
 0.85A 3runA-6cfwM:
undetectable		 3runA-6cfwM:
undetectable