SIMILAR PATTERNS OF AMINO ACIDS FOR 3RUM_A_CCSA375_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v26 LONG-CHAIN-FATTY-ACI
D-COA SYNTHETASE

(Thermus
thermophilus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLN A 474
SER A 303
GLY A 441
LYS A 439
 None
None
None
MYR  A1001 ( 2.8A)
 1.32A 3rumA-1v26A:
0.0		 3rumA-1v26A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b54 NUCLEOSIDE
DIPHOSPHATE KINASE

(Saccharomyces
cerevisiae) 		PF00334
(NDK) 		4 GLN A 147
SER A 145
GLY A  33
LYS A  35
 None
 1.32A 3rumA-3b54A:
0.0		 3rumA-3b54A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N) 		4 GLN A 278
SER A 277
GLY A 301
LYS A 298
 None
 1.13A 3rumA-3foaA:
0.0		 3rumA-3foaA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		4 GLN U 278
SER U 277
GLY U 301
LYS U 298
 None
 1.14A 3rumA-3j2nU:
0.0		 3rumA-3j2nU:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3okz PUTATIVE
UNCHARACTERIZED
PROTEIN GBS0355

(Streptococcus
agalactiae) 		PF03816
(LytR_cpsA_psr) 		4 GLN A 223
SER A 101
GLY A 221
LYS A 224
 None
 1.40A 3rumA-3okzA:
0.0		 3rumA-3okzA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nko ENGINEERED SCFV
HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 GLN B  39
SER B  92
GLY B  44
LYS B  43
 None
 1.41A 3rumA-4nkoB:
0.0		 3rumA-4nkoB:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5goo ALKALINE INVERTASE

(Nostoc sp. PCC
7120) 		PF12899
(Glyco_hydro_100) 		4 GLN A 324
SER A 323
GLY A 391
LYS A 389
 None
 1.30A 3rumA-5gooA:
0.0		 3rumA-5gooA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z73 ALR0819 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 4 GLN A 325
SER A 324
GLY A 392
LYS A 390
 None
 1.28A 3rumA-5z73A:
0.0		 3rumA-5z73A:
undetectable