SIMILAR PATTERNS OF AMINO ACIDS FOR 3RUK_B_AERB601_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b1c | PROTEIN(NADPH-CYTOCHROMEP450 REDUCTASE) (Homo sapiens) |
PF00258(Flavodoxin_1) | 5 | ALA A 52ASN A 19ILE A 68GLY A 49THR A 16 | None | 0.84A | 3rukB-1b1cA:undetectable | 3rukB-1b1cA:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e5m | BETA KETOACYL ACYLCARRIER PROTEINSYNTHASE II (Synechocystissp. PCC 6803) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ALA A 211PHE A 233ILE A 112LEU A 346GLY A 205 | None | 1.07A | 3rukB-1e5mA:undetectable | 3rukB-1e5mA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g5u | PROFILIN (Heveabrasiliensis) |
PF00235(Profilin) | 5 | ALA A1049ILE A1026ILE A1103LEU A1101VAL A1094 | None | 1.00A | 3rukB-1g5uA:undetectable | 3rukB-1g5uA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gju | MALTODEXTRINGLYCOSYLTRANSFERASE (Thermotogamaritima) |
PF00128(Alpha-amylase)PF09083(DUF1923) | 5 | PHE A 128ILE A 556LEU A 553GLY A 133ALA A 134 | None | 0.87A | 3rukB-1gjuA:undetectable | 3rukB-1gjuA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k0r | NUSA (Mycobacteriumtuberculosis) |
PF08529(NusA_N)PF13184(KH_5) | 5 | ILE A 303LEU A 299ASP A 322VAL A 294VAL A 277 | None | 0.69A | 3rukB-1k0rA:undetectable | 3rukB-1k0rA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kt1 | FK506-BINDINGPROTEIN FKBP51 (Saimiriboliviensis) |
PF00254(FKBP_C)PF00515(TPR_1)PF13181(TPR_8) | 5 | PHE A 79ASP A 91GLY A 93ALA A 95VAL A 55 | None | 1.03A | 3rukB-1kt1A:undetectable | 3rukB-1kt1A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kwg | BETA-GALACTOSIDASE (Thermusthermophilus) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 5 | ILE A 57LEU A 60GLY A 34VAL A 67VAL A 133 | None | 1.01A | 3rukB-1kwgA:undetectable | 3rukB-1kwgA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1l | RIBONUCLEOSIDETRIPHOSPHATEREDUCTASE (Lactobacillusleichmannii) |
PF02867(Ribonuc_red_lgC) | 5 | ILE A 477LEU A 481ALA A 636VAL A 489VAL A 490 | None | 1.04A | 3rukB-1l1lA:undetectable | 3rukB-1l1lA:22.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nr6 | CYTOCHROME P450 2C5 (Oryctolaguscuniculus) |
PF00067(p450) | 6 | ALA A 113PHE A 114ASP A 290GLY A 293ALA A 294THR A 298 | DIF A 501 (-3.6A)DIF A 501 (-4.5A)NoneDIF A 501 (-3.8A)DIF A 501 ( 3.3A)HEM A 500 ( 3.6A) | 0.76A | 3rukB-1nr6A:44.1 | 3rukB-1nr6A:32.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5m | PROSTAGLANDIN-E29-REDUCTASE (Oryctolaguscuniculus) |
PF00248(Aldo_ket_red) | 5 | ALA A 269LEU A 261ALA A 253THR A 251VAL A 283 | NoneNoneNDP A1003 (-3.3A)NoneNone | 0.97A | 3rukB-1q5mA:undetectable | 3rukB-1q5mA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgo | ANAEROBIC COBALAMINBIOSYNTHETIC COBALTCHELATASE (Salmonellaenterica) |
PF06180(CbiK) | 5 | ILE A 84ILE A 85LEU A 114GLY A 144ALA A 173 | NoneSO4 A 400 ( 4.2A)NoneNoneNone | 0.96A | 3rukB-1qgoA:undetectable | 3rukB-1qgoA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qqe | VESICULAR TRANSPORTPROTEIN SEC17 (Saccharomycescerevisiae) |
PF14938(SNAP) | 5 | PHE A 240ILE A 280ILE A 276LEU A 277GLY A 206 | None | 1.00A | 3rukB-1qqeA:undetectable | 3rukB-1qqeA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uy4 | ENDO-1,4-BETA-XYLANASE A ([Clostridium]stercorarium) |
PF03422(CBM_6) | 5 | ALA A 74PHE A 72ILE A 63ALA A 26VAL A 58 | None | 0.98A | 3rukB-1uy4A:undetectable | 3rukB-1uy4A:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xp3 | ENDONUCLEASE IV (Bacillusanthracis) |
PF01261(AP_endonuc_2) | 5 | ILE A 127ILE A 128LEU A 131ALA A 163VAL A 169 | None | 0.65A | 3rukB-1xp3A:undetectable | 3rukB-1xp3A:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a5h | L-LYSINE2,3-AMINOMUTASE (Clostridiumsubterminale) |
PF04055(Radical_SAM)PF12544(LAM_C) | 5 | ILE A 184ILE A 185LEU A 188VAL A 197VAL A 225 | None | 0.96A | 3rukB-2a5hA:undetectable | 3rukB-2a5hA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2asb | TRANSCRIPTIONELONGATION PROTEINNUSA (Mycobacteriumtuberculosis) |
PF13184(KH_5) | 5 | ILE A 303LEU A 299ASP A 322VAL A 294VAL A 277 | A B 7 ( 3.6A) A B 7 ( 4.0A) U B 9 ( 3.8A)NoneNone | 0.76A | 3rukB-2asbA:undetectable | 3rukB-2asbA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b9l | PROPHENOLOXIDASEACTIVATING FACTOR (Holotrichiadiomphalia) |
PF00089(Trypsin) | 5 | ILE A 190ALA A 254THR A 197VAL A 194VAL A 195 | None | 1.02A | 3rukB-2b9lA:undetectable | 3rukB-2b9lA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d3l | GLUCAN1,4-ALPHA-MALTOHEXAOSIDASE (Bacillus sp.707) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | ASN A 95ILE A 97ALA A 88VAL A 42VAL A 99 | None | 0.96A | 3rukB-2d3lA:undetectable | 3rukB-2d3lA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d9p | POLYADENYLATE-BINDING PROTEIN 3 (Homo sapiens) |
PF00076(RRM_1) | 5 | ALA A 323ILE A 305LEU A 301VAL A 298VAL A 365 | None | 1.06A | 3rukB-2d9pA:undetectable | 3rukB-2d9pA:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dic | FILAMIN-B (Homo sapiens) |
PF00630(Filamin) | 5 | ALA A 68PHE A 32ILE A 89GLY A 45VAL A 80 | None | 1.06A | 3rukB-2dicA:undetectable | 3rukB-2dicA:11.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fvl | ALDO-KETO REDUCTASEFAMILY 1, MEMBER C4 (Homo sapiens) |
PF00248(Aldo_ket_red) | 5 | ALA A 269LEU A 261ALA A 253THR A 251VAL A 283 | NAP A1001 ( 4.9A)NoneNAP A1001 (-3.4A)NoneNone | 0.94A | 3rukB-2fvlA:undetectable | 3rukB-2fvlA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ggr | PROTO-ONCOGENE C-CRK (Mus musculus) |
PF07653(SH3_2) | 5 | ILE A 238LEU A 293GLY A 277VAL A 291VAL A 242 | None | 0.99A | 3rukB-2ggrA:undetectable | 3rukB-2ggrA:10.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gtx | METHIONINEAMINOPEPTIDASE (Escherichiacoli) |
PF00557(Peptidase_M24) | 5 | PHE A 201ILE A 144LEU A 195GLY A 150VAL A 140 | None | 0.92A | 3rukB-2gtxA:undetectable | 3rukB-2gtxA:17.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i8l | HYDROGENASE 3MATURATION PROTEASE (Escherichiacoli) |
PF01750(HycI) | 5 | ALA A 49ILE A 60LEU A 58GLY A 39VAL A 36 | None | 0.95A | 3rukB-2i8lA:undetectable | 3rukB-2i8lA:16.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ipj | ALDO-KETO REDUCTASEFAMILY 1 MEMBER C2 (Homo sapiens) |
PF00248(Aldo_ket_red) | 5 | ALA A 269LEU A 261ALA A 253THR A 251VAL A 283 | NAP A 1 ( 4.8A)NoneNAP A 1 (-3.5A)NoneNone | 0.91A | 3rukB-2ipjA:undetectable | 3rukB-2ipjA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3r | ZGC 92866 (Danio rerio) |
PF04051(TRAPP) | 5 | ILE B 172LEU B 170ALA B 149THR B 152VAL B 160 | None | 0.99A | 3rukB-2j3rB:undetectable | 3rukB-2j3rB:15.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k1s | INNER MEMBRANELIPOPROTEIN YIAD (Escherichiacoli) |
PF00691(OmpA) | 5 | ALA A 43PHE A 38ILE A 136THR A 110VAL A 134 | None | 0.92A | 3rukB-2k1sA:undetectable | 3rukB-2k1sA:15.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mu3 | ACINIFORM SPIDROIN 1 (Argiopetrifasciata) |
PF12042(RP1-2) | 5 | ILE A 105LEU A 117GLY A 98ALA A 97VAL A 120 | None | 0.92A | 3rukB-2mu3A:undetectable | 3rukB-2mu3A:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p4h | VESTITONE REDUCTASE (Medicago sativa) |
PF01370(Epimerase) | 5 | ILE X 21ILE X 22LEU X 25THR X 35VAL X 32 | None | 0.78A | 3rukB-2p4hX:undetectable | 3rukB-2p4hX:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r7a | BACTERIAL HEMEBINDING PROTEIN (Shigelladysenteriae) |
PF01497(Peripla_BP_2) | 5 | ILE A 186LEU A 189GLY A 260VAL A 267VAL A 266 | None | 0.84A | 3rukB-2r7aA:undetectable | 3rukB-2r7aA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rjt | BETA-KETOACYL-ACPSYNTHASE II (Streptococcuspneumoniae) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ALA A 208PHE A 229ILE A 109LEU A 339GLY A 202 | None | 1.03A | 3rukB-2rjtA:undetectable | 3rukB-2rjtA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vug | PAB1020 (Pyrococcusabyssi) |
PF09414(RNA_ligase) | 5 | ASN A 248ILE A 252ILE A 249ALA A 275VAL A 291 | None | 0.92A | 3rukB-2vugA:undetectable | 3rukB-2vugA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xro | HTH-TYPETRANSCRIPTIONALREGULATOR TTGV (Pseudomonasputida) |
PF01614(IclR)PF09339(HTH_IclR) | 5 | ILE A 53ILE A 54LEU A 57ALA A 26VAL A 63 | None | 1.00A | 3rukB-2xroA:undetectable | 3rukB-2xroA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a1w | IRON(II) TRANSPORTPROTEIN B (Thermotogamaritima) |
PF02421(FeoB_N) | 5 | ILE A 141LEU A 146THR A 157VAL A 154VAL A 155 | None | 0.93A | 3rukB-3a1wA:undetectable | 3rukB-3a1wA:17.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cax | UNCHARACTERIZEDPROTEIN PF0695 (Pyrococcusfuriosus) |
PF01814(Hemerythrin)PF13596(PAS_10) | 5 | ALA A 146PHE A 236ILE A 214ALA A 244VAL A 169 | None | 0.83A | 3rukB-3caxA:undetectable | 3rukB-3caxA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cpx | AMINOPEPTIDASE, M42FAMILY (Cytophagahutchinsonii) |
PF05343(Peptidase_M42) | 5 | ILE A 28ILE A 24LEU A 25ALA A 167THR A 169 | None | 1.06A | 3rukB-3cpxA:undetectable | 3rukB-3cpxA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d7j | UNCHARACTERIZEDPROTEIN SCO6650 (Streptomycescoelicolor) |
PF01242(PTPS) | 5 | ALA A 36LEU A 104GLY A 113VAL A 50VAL A 49 | None | 0.91A | 3rukB-3d7jA:undetectable | 3rukB-3d7jA:16.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3e4e | CYTOCHROME P450 2E1 (Homo sapiens) |
PF00067(p450) | 5 | ALA A 438ILE A 183LEU A 265GLY A 300ALA A 299 | HEM A 500 (-3.8A)NoneNoneHEM A 500 (-3.4A)HEM A 500 ( 3.3A) | 0.98A | 3rukB-3e4eA:43.4 | 3rukB-3e4eA:31.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g74 | PROTEIN OF UNKNOWNFUNCTION (Eubacteriumventriosum) |
PF12164(SporV_AA) | 5 | ILE A 15GLY A 23ALA A 26VAL A 85VAL A 13 | None | 1.00A | 3rukB-3g74A:undetectable | 3rukB-3g74A:13.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrd | NICOTINATEDEHYDROGENASE MEDIUMMOLYBDOPTERINSUBUNIT (Eubacteriumbarkeri) |
PF02738(Ald_Xan_dh_C2) | 5 | ALA B 189ILE B 316LEU B 236ALA B 301VAL B 235 | None | 1.06A | 3rukB-3hrdB:undetectable | 3rukB-3hrdB:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k6g | TELOMERICREPEAT-BINDINGFACTOR 2-INTERACTINGPROTEIN 1 (Homo sapiens) |
PF11626(Rap1_C) | 5 | ILE A 317ILE A 318LEU A 321GLY A 341VAL A 332 | None | 0.92A | 3rukB-3k6gA:undetectable | 3rukB-3k6gA:14.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lpz | GET4 (YOR164CHOMOLOG) (Chaetomiumthermophilum) |
PF04190(DUF410) | 5 | ILE A 8ILE A 9LEU A 12ALA A 47VAL A 54 | None | 0.69A | 3rukB-3lpzA:undetectable | 3rukB-3lpzA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mq3 | PYRUVATEDEHYDROGENASEPHOSPHATASE 1 (Bos taurus) |
PF00481(PP2C) | 5 | ILE A 449ILE A 412LEU A 411GLY A 348VAL A 416 | None | 1.06A | 3rukB-3mq3A:undetectable | 3rukB-3mq3A:24.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nu8 | AMINOTRANSFERASEWBPE (Pseudomonasaeruginosa) |
PF01041(DegT_DnrJ_EryC1) | 5 | ILE A 18ILE A 22ALA A 235THR A 232VAL A 25 | None | 1.02A | 3rukB-3nu8A:undetectable | 3rukB-3nu8A:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pm0 | CYTOCHROME P450 1B1 (Homo sapiens) |
PF00067(p450) | 6 | ALA A 133PHE A 134ASP A 326GLY A 329ALA A 330THR A 334 | HEM A 900 (-3.3A)BHF A 800 (-4.8A)BHF A 800 (-3.4A)BHF A 800 ( 4.0A)HEM A 900 ( 3.4A)HEM A 900 ( 3.2A) | 0.52A | 3rukB-3pm0A:41.4 | 3rukB-3pm0A:29.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3puo | DIHYDRODIPICOLINATESYNTHASE (Pseudomonasaeruginosa) |
PF00701(DHDPS) | 5 | ILE A 74GLY A 43THR A 11VAL A 60VAL A 59 | None | 1.04A | 3rukB-3puoA:undetectable | 3rukB-3puoA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sqg | METHYL-COENZYME MREDUCTASE, BETASUBUNIT (unculturedarchaeon) |
PF02241(MCR_beta)PF02783(MCR_beta_N) | 5 | ALA B 267ASN B 326ILE B 327GLY B 309ALA B 308 | None | 0.96A | 3rukB-3sqgB:undetectable | 3rukB-3sqgB:24.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tbh | O-ACETYL SERINESULFHYDRYLASE (Leishmaniadonovani) |
PF00291(PALP) | 5 | ILE A 231GLY A 253ALA A 252THR A 213VAL A 210 | None | 0.89A | 3rukB-3tbhA:undetectable | 3rukB-3tbhA:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3voq | TARGET OF RAPAMYCINCOMPLEX 2 SUBUNITMAPKAP1 (Homo sapiens) |
PF16979(SIN1_PH) | 5 | PHE A 453ILE A 411LEU A 402THR A 397VAL A 388 | None | 0.97A | 3rukB-3voqA:undetectable | 3rukB-3voqA:15.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ain | GLYCINE BETAINETRANSPORTER BETP (Corynebacteriumglutamicum) |
PF02028(BCCT) | 5 | ALA A 242PHE A 529ILE A 196ILE A 199GLY A 382 | None | 1.07A | 3rukB-4ainA:undetectable | 3rukB-4ainA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f32 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Burkholderiavietnamiensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ALA A 216PHE A 239ILE A 117LEU A 351GLY A 210 | N32 A 501 ( 4.2A)N32 A 501 ( 4.3A)NoneCSU A 172 ( 3.9A)None | 0.95A | 3rukB-4f32A:undetectable | 3rukB-4f32A:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g1k | TRIOSEPHOSPHATEISOMERASE (Burkholderiathailandensis) |
PF00121(TIM) | 5 | ALA A 219PHE A 223ILE A 42ALA A 245VAL A 9 | None | 1.03A | 3rukB-4g1kA:undetectable | 3rukB-4g1kA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4glx | DNA LIGASE (Escherichiacoli) |
PF01653(DNA_ligase_aden)PF03119(DNA_ligase_ZBD)PF03120(DNA_ligase_OB)PF12826(HHH_2)PF14520(HHH_5) | 5 | PHE A 443ILE A 573LEU A 576THR A 507VAL A 581 | NoneNoneNoneSO4 A 602 ( 3.9A)None | 1.00A | 3rukB-4glxA:undetectable | 3rukB-4glxA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hqe | TRANSCRIPTIONALREGULATOR QSRR (Staphylococcusaureus) |
PF01638(HxlR) | 5 | ASN A 20ILE A 23ILE A 24LEU A 27ALA A 60 | None | 0.75A | 3rukB-4hqeA:undetectable | 3rukB-4hqeA:12.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4i8v | CYTOCHROME P450 1A1 (Homo sapiens) |
PF00067(p450) | 5 | PHE A 123ASP A 313GLY A 316ALA A 317THR A 321 | NoneBHF A 602 (-3.7A)BHF A 602 (-3.5A)BHF A 602 ( 3.4A)HEM A 601 (-3.4A) | 0.60A | 3rukB-4i8vA:42.6 | 3rukB-4i8vA:33.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j5i | ALPHA-KETOGLUTARATE-DEPENDENT TAURINEDIOXYGENASE (Mycolicibacteriumsmegmatis) |
PF02668(TauD) | 5 | ALA A 239PHE A 45LEU A 9THR A 246VAL A 229 | None | 0.99A | 3rukB-4j5iA:undetectable | 3rukB-4j5iA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jb6 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Pseudomonasaeruginosa) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ALA A 208PHE A 230ILE A 109LEU A 343GLY A 202 | None | 0.96A | 3rukB-4jb6A:undetectable | 3rukB-4jb6A:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jga | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Rickettsiarickettsii) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ALA A 221PHE A 244ILE A 122LEU A 357GLY A 215 | NoneNoneEDO A 502 (-4.9A)NoneNone | 0.87A | 3rukB-4jgaA:undetectable | 3rukB-4jgaA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhp | X-LINKED RETINITISPIGMENTOSA GTPASEREGULATOR (Homo sapiens) |
PF00415(RCC1) | 5 | ILE C 300ALA C 262THR C 259VAL C 256VAL C 257 | None | 1.04A | 3rukB-4jhpC:undetectable | 3rukB-4jhpC:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jmd | PUTATIVEUNCHARACTERIZEDPROTEIN MPPR (Streptomyceshygroscopicus) |
PF06314(ADC) | 5 | ALA A 92ILE A 248ASP A 66GLY A 276VAL A 62 | None | 0.97A | 3rukB-4jmdA:undetectable | 3rukB-4jmdA:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jmf | EXOENZYME TPROBABLE CHAPERONE (Pseudomonasaeruginosa) |
PF05932(CesT)no annotation | 5 | PHE B 50ILE A 68ILE A 69LEU A 72VAL B 27 | None | 0.93A | 3rukB-4jmfB:undetectable | 3rukB-4jmfB:12.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jrm | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Vibrio cholerae) |
no annotation | 5 | ALA D 208PHE D 230ILE D 109LEU D 344GLY D 202 | None | 0.87A | 3rukB-4jrmD:undetectable | 3rukB-4jrmD:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kp2 | HOMOACONITASE LARGESUBUNIT (Methanocaldococcusjannaschii) |
PF00330(Aconitase) | 5 | ALA A 184GLY A 219ALA A 211VAL A 175VAL A 172 | None | 1.03A | 3rukB-4kp2A:undetectable | 3rukB-4kp2A:24.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ls5 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ALA A 207PHE A 228ILE A 108LEU A 341GLY A 201 | None | 1.06A | 3rukB-4ls5A:undetectable | 3rukB-4ls5A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m38 | PROTEIN ARGININEN-METHYLTRANSFERASE7 (Trypanosomabrucei) |
PF06325(PrmA) | 5 | PHE A 358LEU A 337ALA A 291VAL A 348VAL A 349 | None | 1.08A | 3rukB-4m38A:undetectable | 3rukB-4m38A:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m6r | METHYLTHIORIBULOSE-1-PHOSPHATEDEHYDRATASE (Homo sapiens) |
PF00596(Aldolase_II) | 5 | ILE A 135LEU A 159ALA A 121THR A 125VAL A 161 | None | 1.08A | 3rukB-4m6rA:undetectable | 3rukB-4m6rA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n78 | CYTOPLASMICFMR1-INTERACTINGPROTEIN 1 (Homo sapiens) |
PF05994(FragX_IP)PF07159(DUF1394) | 5 | ASN A1215ILE A1218ILE A1219LEU A1222VAL A1166 | None | 0.62A | 3rukB-4n78A:undetectable | 3rukB-4n78A:18.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nky | STEROID17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) |
PF00067(p450) | 12 | ALA A 113PHE A 114ASN A 202ILE A 205ILE A 206LEU A 209ASP A 298GLY A 301ALA A 302THR A 306VAL A 482VAL A 483 | HEM A 600 ( 2.9A)3QZ A 601 ( 4.1A)3QZ A 601 (-3.5A)3QZ A 601 ( 3.4A)3QZ A 601 ( 4.6A)3QZ A 601 ( 4.8A)3QZ A 601 (-3.5A)3QZ A 601 ( 3.0A)3QZ A 601 (-2.9A)HEM A 600 ( 3.2A)3QZ A 601 (-4.1A)3QZ A 601 (-4.1A) | 0.38A | 3rukB-4nkyA:62.9 | 3rukB-4nkyA:99.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o4o | PHYCOCYANOBILINLYASE CPCT (Nostoc sp. PCC7120) |
PF06206(CpeT) | 5 | PHE A 51ILE A 7ILE A 196GLY A 48VAL A 194 | None | 1.04A | 3rukB-4o4oA:undetectable | 3rukB-4o4oA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ox8 | CARBONDIOXIDE-CONCENTRATING MECHANISM PROTEINCCMK (Prochlorococcusmarinus) |
PF00936(BMC) | 5 | ILE A 82ILE A 81LEU A 10ALA A 78VAL A 62 | None | 1.07A | 3rukB-4ox8A:undetectable | 3rukB-4ox8A:14.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p6v | NA(+)-TRANSLOCATINGNADH-QUINONEREDUCTASE SUBUNIT D (Vibrio cholerae) |
PF02508(Rnf-Nqr) | 5 | ALA D 118ILE D 109ILE D 108VAL D 51VAL D 48 | None | 1.06A | 3rukB-4p6vD:undetectable | 3rukB-4p6vD:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qav | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Neisseriameningitidis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ALA A 209PHE A 231ILE A 110LEU A 342GLY A 203 | None | 0.93A | 3rukB-4qavA:undetectable | 3rukB-4qavA:20.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r1z | CYP17A1 PROTEIN (Danio rerio) |
PF00067(p450) | 8 | ALA A 126ILE A 218ASP A 309GLY A 312ALA A 313THR A 317VAL A 493VAL A 494 | HEM A 600 (-3.6A)AER A 601 ( 4.3A)AER A 601 ( 4.1A)AER A 601 ( 3.7A)HEM A 600 (-3.5A)HEM A 600 ( 3.3A)NoneNone | 0.64A | 3rukB-4r1zA:51.1 | 3rukB-4r1zA:46.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r1z | CYP17A1 PROTEIN (Danio rerio) |
PF00067(p450) | 6 | ALA A 126PHE A 127ASP A 309ALA A 313THR A 317VAL A 494 | HEM A 600 (-3.6A)NoneAER A 601 ( 4.1A)HEM A 600 (-3.5A)HEM A 600 ( 3.3A)None | 0.64A | 3rukB-4r1zA:51.1 | 3rukB-4r1zA:46.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r20 | CYTOCHROME P450FAMILY 17POLYPEPTIDE 2 (Danio rerio) |
PF00067(p450) | 6 | ALA A 120PHE A 121ASN A 209GLY A 301ALA A 302THR A 306 | AER A 602 (-3.7A)NoneAER A 602 (-4.5A)AER A 602 ( 3.8A)HEM A 601 (-3.4A)HEM A 601 ( 3.3A) | 0.74A | 3rukB-4r20A:49.6 | 3rukB-4r20A:43.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r20 | CYTOCHROME P450FAMILY 17POLYPEPTIDE 2 (Danio rerio) |
PF00067(p450) | 6 | ALA A 120PHE A 121GLY A 301ALA A 302THR A 306VAL A 481 | AER A 602 (-3.7A)NoneAER A 602 ( 3.8A)HEM A 601 (-3.4A)HEM A 601 ( 3.3A)None | 0.58A | 3rukB-4r20A:49.6 | 3rukB-4r20A:43.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r20 | CYTOCHROME P450FAMILY 17POLYPEPTIDE 2 (Danio rerio) |
PF00067(p450) | 5 | ASN A 209ILE A 212ALA A 302THR A 306VAL A 480 | AER A 602 (-4.5A)AER A 602 (-3.2A)HEM A 601 (-3.4A)HEM A 601 ( 3.3A)AER A 602 ( 4.9A) | 0.66A | 3rukB-4r20A:49.6 | 3rukB-4r20A:43.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r20 | CYTOCHROME P450FAMILY 17POLYPEPTIDE 2 (Danio rerio) |
PF00067(p450) | 5 | ASN A 209ILE A 212GLY A 301ALA A 302THR A 306 | AER A 602 (-4.5A)AER A 602 (-3.2A)AER A 602 ( 3.8A)HEM A 601 (-3.4A)HEM A 601 ( 3.3A) | 0.63A | 3rukB-4r20A:49.6 | 3rukB-4r20A:43.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r20 | CYTOCHROME P450FAMILY 17POLYPEPTIDE 2 (Danio rerio) |
PF00067(p450) | 5 | ILE A 212ALA A 302THR A 306VAL A 480VAL A 481 | AER A 602 (-3.2A)HEM A 601 (-3.4A)HEM A 601 ( 3.3A)AER A 602 ( 4.9A)None | 0.75A | 3rukB-4r20A:49.6 | 3rukB-4r20A:43.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r20 | CYTOCHROME P450FAMILY 17POLYPEPTIDE 2 (Danio rerio) |
PF00067(p450) | 5 | ILE A 212GLY A 301ALA A 302THR A 306VAL A 481 | AER A 602 (-3.2A)AER A 602 ( 3.8A)HEM A 601 (-3.4A)HEM A 601 ( 3.3A)None | 0.51A | 3rukB-4r20A:49.6 | 3rukB-4r20A:43.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uzs | BETA-GALACTOSIDASE (Bifidobacteriumbifidum) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 5 | ILE A 77LEU A 80GLY A 54ALA A 90VAL A 153 | POL A 706 ( 4.1A)NoneNoneNoneNone | 0.88A | 3rukB-4uzsA:undetectable | 3rukB-4uzsA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xox | 3-OXOACYL-ACPSYNTHASE (Vibrio cholerae) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ALA A 102ILE A 341GLY A 233ALA A 75VAL A 236 | None | 0.94A | 3rukB-4xoxA:undetectable | 3rukB-4xoxA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a2f | CD166 ANTIGEN (Homo sapiens) |
PF08205(C2-set_2) | 5 | ILE A 40ILE A 41ALA A 103VAL A 31VAL A 128 | None | 1.07A | 3rukB-5a2fA:undetectable | 3rukB-5a2fA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5az4 | FLAGELLAR HOOKSUBUNIT PROTEIN (Campylobacterjejuni) |
PF07196(Flagellin_IN)PF07559(FlaE) | 5 | PHE A 602LEU A 510THR A 540VAL A 537VAL A 538 | None | 1.08A | 3rukB-5az4A:undetectable | 3rukB-5az4A:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c3u | L-SERINEAMMONIA-LYASE (Rhizomucormiehei) |
PF00291(PALP) | 5 | ASN A 186ILE A 189GLY A 182VAL A 202VAL A 253 | NoneNonePLP A 401 (-3.4A)NoneNone | 1.03A | 3rukB-5c3uA:undetectable | 3rukB-5c3uA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cca | ENDORIBONUCLEASEMAZF3 (Mycobacteriumtuberculosis) |
PF02452(PemK_toxin) | 5 | ILE A 68LEU A 73ALA A 33THR A 65VAL A 30 | None | 0.93A | 3rukB-5ccaA:undetectable | 3rukB-5ccaA:16.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5flw | EXO-BETA-1,3-GALACTANASE (Bifidobacteriumbifidum) |
PF04616(Glyco_hydro_43) | 5 | PHE A 56ILE A 23LEU A 25VAL A 249VAL A 248 | None | 1.03A | 3rukB-5flwA:undetectable | 3rukB-5flwA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ftf | TPR DOMAIN PROTEIN (Bacteroides sp.3_1_23) |
PF05970(PIF1) | 5 | ILE A 118ILE A 114LEU A 115ALA A 53THR A 55 | None | 0.96A | 3rukB-5ftfA:undetectable | 3rukB-5ftfA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ftf | TPR DOMAIN PROTEIN (Bacteroides sp.3_1_23) |
PF05970(PIF1) | 5 | ILE A 118ILE A 114LEU A 115THR A 55VAL A 110 | None | 1.01A | 3rukB-5ftfA:undetectable | 3rukB-5ftfA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gxd | AMP-DEPENDENTSYNTHETASE ANDLIGASE (Dinoroseobactershibae) |
PF00501(AMP-binding)PF13193(AMP-binding_C)PF16177(ACAS_N) | 5 | ALA A 524ASN A 596ILE A 597LEU A 622GLY A 592 | None | 0.96A | 3rukB-5gxdA:undetectable | 3rukB-5gxdA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h20 | PUTATIVE PADR-FAMILYTRANSCRIPTIONALREGULATORY PROTEIN (Bacteroidesfragilis) |
PF03551(PadR) | 5 | ILE A 33ILE A 34LEU A 37VAL A 44VAL A 45 | None | 1.00A | 3rukB-5h20A:undetectable | 3rukB-5h20A:11.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kei | 2,3-DIHYDROXYBENZOATE-AMP LIGASE (Mycolicibacteriumsmegmatis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | PHE A 353ILE A 386ILE A 388LEU A 404VAL A 438 | None | 1.06A | 3rukB-5keiA:undetectable | 3rukB-5keiA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mdn | DNA POLYMERASE (Pyrobaculumcalidifontis) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 5 | ALA A 54ILE A 80ALA A 44VAL A 69VAL A 70 | None | 1.06A | 3rukB-5mdnA:undetectable | 3rukB-5mdnA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ux5 | BIFUNCTIONAL PROTEINPROLINE UTILIZATIONA (PUTA) (Corynebacteriumfreiburgense) |
PF00171(Aldedh)PF01619(Pro_dh) | 5 | ASN A 531ILE A 532LEU A 536ALA A 526VAL A 555 | None | 0.86A | 3rukB-5ux5A:undetectable | 3rukB-5ux5A:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vm1 | XYLULOKINASE (Brucella ovis) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | ILE A 407LEU A 411ALA A 416THR A 454VAL A 413 | None | 0.99A | 3rukB-5vm1A:undetectable | 3rukB-5vm1A:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y1i | CYTOCHROME P450 (Streptomycesgraminofaciens) |
PF00067(p450) | 5 | ASN A 181ILE A 185GLY A 247ALA A 248THR A 252 | NoneNoneNoneHEM A 501 (-3.4A)HEM A 501 (-3.9A) | 1.02A | 3rukB-5y1iA:30.7 | 3rukB-5y1iA:24.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b82 | CYTOCHROME P450,FAMILY 17, SUBFAMILYA, POLYPEPTIDE 1 (Danio rerio) |
no annotation | 8 | ALA A 126PHE A 127ILE A 218GLY A 312ALA A 313THR A 317VAL A 493VAL A 494 | HEM A 601 (-3.8A)NoneAER A 602 (-3.9A)AER A 602 ( 3.7A)HEM A 601 (-3.6A)HEM A 601 ( 3.7A)AER A 602 ( 4.7A)None | 0.61A | 3rukB-6b82A:49.0 | 3rukB-6b82A:9.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfd | ATP-DEPENDENT CLPPROTEASE PROTEOLYTICSUBUNIT (Enterococcusfaecium) |
no annotation | 5 | ALA A 106ILE A 44ILE A 45LEU A 48GLY A 74 | None | 0.66A | 3rukB-6cfdA:undetectable | 3rukB-6cfdA:11.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ct0 | DIHYDROLIPOYLLYSINE-RESIDUEACETYLTRANSFERASECOMPONENT OFPYRUVATEDEHYDROGENASECOMPLEX,MITOCHONDRIAL (Homo sapiens) |
no annotation | 5 | ASN 0 477ILE 0 480ILE 0 481ALA 0 514VAL 0 511 | None | 0.97A | 3rukB-6ct00:undetectable | 3rukB-6ct00:8.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f2u | ALDO-KETO REDUCTASEFAMILY 1 MEMBER C3 (Homo sapiens) |
no annotation | 5 | ALA A 269LEU A 261ALA A 253THR A 251VAL A 283 | NAP A 401 ( 4.7A)NoneNAP A 401 (-3.4A)NoneNone | 0.94A | 3rukB-6f2uA:undetectable | 3rukB-6f2uA:10.79 |