SIMILAR PATTERNS OF AMINO ACIDS FOR 3RQL_B_H4BB760
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a88 | CHLOROPEROXIDASE L (Streptomyceslividans) |
PF00561(Abhydrolase_1) | 4 | PHE A 207GLU A 204SER A 203ARG A 104 | None | 1.37A | 3rqlA-1a88A:0.03rqlB-1a88A:0.0 | 3rqlA-1a88A:21.833rqlB-1a88A:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c4k | PROTEIN (ORNITHINEDECARBOXYLASE) (Lactobacillussp. 30A) |
PF01276(OKR_DC_1)PF03709(OKR_DC_1_N)PF03711(OKR_DC_1_C) | 4 | TRP A 673PHE A 681GLU A 649VAL A 667 | None | 1.31A | 3rqlA-1c4kA:0.03rqlB-1c4kA:undetectable | 3rqlA-1c4kA:19.073rqlB-1c4kA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eyx | R-PHYCOERYTHRIN (Gracilariachilensis) |
PF00502(Phycobilisome) | 4 | GLU A 25SER A 26ARG A 17VAL A 8 | None | 1.35A | 3rqlA-1eyxA:2.23rqlB-1eyxA:undetectable | 3rqlA-1eyxA:17.953rqlB-1eyxA:17.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1flg | PROTEIN(QUINOPROTEINETHANOLDEHYDROGENASE) (Pseudomonasaeruginosa) |
PF01011(PQQ)PF13360(PQQ_2) | 4 | PHE A 501GLU A 519VAL A 41TRP A 521 | None | 1.34A | 3rqlA-1flgA:undetectable3rqlB-1flgA:undetectable | 3rqlA-1flgA:19.673rqlB-1flgA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h2t | 80 KDA NUCLEAR CAPBINDING PROTEIN (Homo sapiens) |
PF02854(MIF4G)PF09088(MIF4G_like)PF09090(MIF4G_like_2) | 4 | PHE C 360GLU C 353MET C 291VAL C 216 | None | 1.26A | 3rqlA-1h2tC:0.03rqlB-1h2tC:0.0 | 3rqlA-1h2tC:19.483rqlB-1h2tC:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h3j | PEROXIDASE (Coprinopsiscinerea) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 4 | TRP A 258PHE A 211MET A 268VAL A 177 | NoneHSO A 183 ( 3.5A)NoneNone | 1.26A | 3rqlA-1h3jA:undetectable3rqlB-1h3jA:0.0 | 3rqlA-1h3jA:22.843rqlB-1h3jA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kfu | M-CALPAIN LARGESUBUNIT (Homo sapiens) |
PF00648(Peptidase_C2)PF01067(Calpain_III)PF13833(EF-hand_8) | 4 | PHE L 502GLU L 339SER L 236ARG L 500 | None | 0.92A | 3rqlA-1kfuL:undetectable3rqlB-1kfuL:0.0 | 3rqlA-1kfuL:20.983rqlB-1kfuL:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kh2 | ARGININOSUCCINATESYNTHETASE (Thermusthermophilus) |
PF00764(Arginosuc_synth) | 4 | PHE A 220GLU A 222ARG A 282VAL A 226 | None | 1.31A | 3rqlA-1kh2A:0.03rqlB-1kh2A:0.0 | 3rqlA-1kh2A:22.653rqlB-1kh2A:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kl9 | EUKARYOTICTRANSLATIONINITIATION FACTOR 2SUBUNIT 1 (Homo sapiens) |
PF00575(S1)PF07541(EIF_2_alpha) | 4 | PHE A 130GLU A 37SER A 104VAL A 107 | None | 1.36A | 3rqlA-1kl9A:2.63rqlB-1kl9A:undetectable | 3rqlA-1kl9A:17.333rqlB-1kl9A:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5j | ACONITATE HYDRATASE2 (Escherichiacoli) |
PF00330(Aconitase)PF06434(Aconitase_2_N)PF11791(Aconitase_B_N) | 4 | TRP A 155PHE A 156GLU A 154ARG A 340 | None | 1.36A | 3rqlA-1l5jA:3.73rqlB-1l5jA:0.0 | 3rqlA-1l5jA:19.283rqlB-1l5jA:19.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1lzx | NITRIC-OXIDESYNTHASE (Rattusnorvegicus) |
PF02898(NO_synthase) | 5 | SER A 334MET A 336ARG A 596VAL A 677TRP A 678 | NoneH4B A 760 ( 3.8A)H4B A 760 (-3.5A)H4B A 760 (-4.6A)H4B A 760 ( 3.6A) | 0.43A | 3rqlA-1lzxA:62.63rqlB-1lzxA:62.3 | 3rqlA-1lzxA:100.003rqlB-1lzxA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mzb | FERRIC UPTAKEREGULATION PROTEIN (Pseudomonasaeruginosa) |
PF01475(FUR) | 4 | PHE A 79GLU A 36ARG A 69VAL A 54 | None | 1.03A | 3rqlA-1mzbA:undetectable3rqlB-1mzbA:undetectable | 3rqlA-1mzbA:16.593rqlB-1mzbA:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o1y | CONSERVEDHYPOTHETICAL PROTEINTM1158 (Thermotogamaritima) |
PF00117(GATase) | 4 | GLU A 155SER A 154ARG A 133VAL A 116 | NoneNoneSO4 A 404 ( 4.6A)None | 1.36A | 3rqlA-1o1yA:undetectable3rqlB-1o1yA:undetectable | 3rqlA-1o1yA:20.703rqlB-1o1yA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pdu | NUCLEAR HORMONERECEPTOR HR38 (Drosophilamelanogaster) |
PF00104(Hormone_recep) | 4 | TRP A 435PHE A 432MET A 440VAL A 401 | None | 1.03A | 3rqlA-1pduA:undetectable3rqlB-1pduA:undetectable | 3rqlA-1pduA:21.053rqlB-1pduA:21.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qw5 | NITRIC OXIDESYNTHASE, INDUCIBLE (Mus musculus) |
PF02898(NO_synthase) | 4 | SER A 112MET A 114ARG A 375TRP A 457 | H4B A 901 (-4.8A)H4B A 901 (-4.0A)H4B A 901 (-3.4A)H4B A 901 ( 3.7A) | 0.34A | 3rqlA-1qw5A:57.93rqlB-1qw5A:58.0 | 3rqlA-1qw5A:63.903rqlB-1qw5A:63.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wf0 | TAR DNA-BINDINGPROTEIN-43 (Homo sapiens) |
PF00076(RRM_1) | 4 | PHE A 26GLU A 21MET A 17VAL A 35 | None | 1.12A | 3rqlA-1wf0A:undetectable3rqlB-1wf0A:undetectable | 3rqlA-1wf0A:11.853rqlB-1wf0A:11.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wql | ETHYLBENZENEDIOXYGENASE SMALLSUBUNIT (Pseudomonasfluorescens) |
PF00866(Ring_hydroxyl_B) | 4 | PHE B 163GLU B 26ARG B 156VAL B 128 | None | 1.18A | 3rqlA-1wqlB:undetectable3rqlB-1wqlB:undetectable | 3rqlA-1wqlB:19.793rqlB-1wqlB:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x6m | GLUTATHIONE-DEPENDENTFORMALDEHYDE-ACTIVATING ENZYME (Paracoccusdenitrificans) |
PF04828(GFA) | 4 | GLU A 149SER A 150ARG A 161VAL A 152 | None | 1.36A | 3rqlA-1x6mA:undetectable3rqlB-1x6mA:undetectable | 3rqlA-1x6mA:18.853rqlB-1x6mA:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ys9 | PROTEIN SPY1043 (Streptococcuspyogenes) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 4 | PHE A 27GLU A 251SER A 248VAL A 225 | None | 1.29A | 3rqlA-1ys9A:undetectable3rqlB-1ys9A:undetectable | 3rqlA-1ys9A:20.933rqlB-1ys9A:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b39 | C3 (Bos taurus) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 4 | PHE A 722GLU A 693ARG A 708VAL A1424 | None | 1.05A | 3rqlA-2b39A:2.53rqlB-2b39A:undetectable | 3rqlA-2b39A:13.583rqlB-2b39A:13.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1w | ENDOU PROTEIN (Xenopus laevis) |
PF09412(XendoU) | 4 | PHE A 246GLU A 251SER A 254VAL A 269 | None | 1.36A | 3rqlA-2c1wA:undetectable3rqlB-2c1wA:undetectable | 3rqlA-2c1wA:20.723rqlB-2c1wA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fja | ADENYLYLSULFATEREDUCTASE, SUBUNIT A (Archaeoglobusfulgidus) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 4 | GLU A 555ARG A 586VAL A 578TRP A 579 | None | 1.29A | 3rqlA-2fjaA:undetectable3rqlB-2fjaA:undetectable | 3rqlA-2fjaA:22.293rqlB-2fjaA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fja | ADENYLYLSULFATEREDUCTASE, SUBUNIT AADENYLYLSULFATEREDUCTASE, SUBUNIT B (Archaeoglobusfulgidus) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C)PF12139(APS-reductase_C)PF13187(Fer4_9) | 4 | TRP B 788GLU A 360ARG A 62VAL A 367 | None | 1.36A | 3rqlA-2fjaB:undetectable3rqlB-2fjaB:undetectable | 3rqlA-2fjaB:18.253rqlB-2fjaB:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ftp | HYDROXYMETHYLGLUTARYL-COA LYASE (Pseudomonasaeruginosa) |
PF00682(HMGL-like) | 4 | PHE A 87GLU A 92SER A 93VAL A 95 | None | 0.93A | 3rqlA-2ftpA:undetectable3rqlB-2ftpA:undetectable | 3rqlA-2ftpA:20.783rqlB-2ftpA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g6z | DUAL SPECIFICITYPROTEIN PHOSPHATASE5 (Homo sapiens) |
PF00782(DSPc) | 4 | GLU A 264SER A 263VAL A 211TRP A 227 | SO4 A 502 ( 3.9A)SO4 A 501 (-2.6A)NoneNone | 1.34A | 3rqlA-2g6zA:undetectable3rqlB-2g6zA:undetectable | 3rqlA-2g6zA:19.483rqlB-2g6zA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hnl | GLUTATHIONES-TRANSFERASE 1 (Onchocercavolvulus) |
PF02798(GST_N)PF14497(GST_C_3) | 4 | PHE A 142GLU A 147SER A 148MET A 151 | None | 1.28A | 3rqlA-2hnlA:undetectable3rqlB-2hnlA:undetectable | 3rqlA-2hnlA:18.623rqlB-2hnlA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2if6 | HYPOTHETICAL PROTEINYIIX (Escherichiacoli) |
PF05708(Peptidase_C92) | 4 | GLU A 130SER A 129ARG A 143VAL A 184 | UNX A 1 (-2.2A)NoneNoneNone | 1.36A | 3rqlA-2if6A:undetectable3rqlB-2if6A:undetectable | 3rqlA-2if6A:18.893rqlB-2if6A:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pag | HYPOTHETICAL PROTEIN (Pseudomonassyringae groupgenomosp. 3) |
PF14567(SUKH_5) | 4 | PHE A 42SER A 123VAL A 106TRP A 127 | None | 1.31A | 3rqlA-2pagA:undetectable3rqlB-2pagA:undetectable | 3rqlA-2pagA:16.013rqlB-2pagA:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pv3 | CHAPERONE SURA (Escherichiacoli) |
PF00639(Rotamase)PF09312(SurA_N) | 4 | PHE A 406SER A 412MET A 414TRP A 413 | None | 1.35A | 3rqlA-2pv3A:undetectable3rqlB-2pv3A:undetectable | 3rqlA-2pv3A:22.593rqlB-2pv3A:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vof | BCL-2-RELATEDPROTEIN A1 (Mus musculus) |
PF00452(Bcl-2) | 4 | PHE A 93GLU A 14SER A 119VAL A 122 | None | 1.35A | 3rqlA-2vofA:1.23rqlB-2vofA:undetectable | 3rqlA-2vofA:16.593rqlB-2vofA:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xvg | ALPHA XYLOSIDASE (Cellvibriojaponicus) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF17137(DUF5110) | 4 | PHE A 698GLU A 722ARG A 697VAL A 717 | None | 1.33A | 3rqlA-2xvgA:0.03rqlB-2xvgA:undetectable | 3rqlA-2xvgA:19.683rqlB-2xvgA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xw7 | DIHYDROFOLATEREDUCTASE (Mycolicibacteriumsmegmatis) |
PF01872(RibD_C) | 4 | TRP A 152GLU A 151SER A 150VAL A 122 | None | 1.28A | 3rqlA-2xw7A:undetectable3rqlB-2xw7A:undetectable | 3rqlA-2xw7A:18.143rqlB-2xw7A:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywb | GMP SYNTHASE[GLUTAMINE-HYDROLYZING] (Thermusthermophilus) |
PF00117(GATase)PF00958(GMP_synt_C) | 4 | PHE A 309GLU A 305ARG A 211VAL A 239 | None | 1.34A | 3rqlA-2ywbA:undetectable3rqlB-2ywbA:undetectable | 3rqlA-2ywbA:21.543rqlB-2ywbA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a24 | ALPHA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF10566(Glyco_hydro_97)PF14508(GH97_N)PF14509(GH97_C) | 4 | GLU A 140SER A 60VAL A 68TRP A 69 | None | 1.20A | 3rqlA-3a24A:0.83rqlB-3a24A:undetectable | 3rqlA-3a24A:20.593rqlB-3a24A:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bjd | PUTATIVE3-OXOACYL-(ACYL-CARRIER-PROTEIN)SYNTHASE (Pseudomonasaeruginosa) |
PF14515(HOASN)PF14518(Haem_oxygenas_2) | 4 | GLU A 122SER A 127ARG A 256VAL A 130 | None | 1.36A | 3rqlA-3bjdA:undetectable3rqlB-3bjdA:undetectable | 3rqlA-3bjdA:21.533rqlB-3bjdA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3by9 | SENSOR PROTEIN (Vibrio cholerae) |
PF02743(dCache_1) | 4 | TRP A 185GLU A 182SER A 205MET A 203 | None | 1.35A | 3rqlA-3by9A:undetectable3rqlB-3by9A:undetectable | 3rqlA-3by9A:19.423rqlB-3by9A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d2w | TAR DNA-BINDINGPROTEIN 43 (Mus musculus) |
PF00076(RRM_1) | 4 | PHE A 211GLU A 206MET A 202VAL A 220 | None | 1.06A | 3rqlA-3d2wA:undetectable3rqlB-3d2wA:undetectable | 3rqlA-3d2wA:12.223rqlB-3d2wA:12.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3e7g | NITRIC OXIDESYNTHASE, INDUCIBLE (Homo sapiens) |
PF02898(NO_synthase) | 4 | SER A 118MET A 120ARG A 381TRP A 463 | NoneH4B A 902 (-3.8A)H4B A 902 (-3.9A)H4B A 902 ( 3.6A) | 0.47A | 3rqlA-3e7gA:57.33rqlB-3e7gA:57.5 | 3rqlA-3e7gA:65.643rqlB-3e7gA:65.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3efa | PUTATIVEACETYLTRANSFERASE (Lactobacillusplantarum) |
PF13673(Acetyltransf_10) | 4 | PHE A 35SER A 30ARG A 19VAL A 24 | None | 1.24A | 3rqlA-3efaA:undetectable3rqlB-3efaA:undetectable | 3rqlA-3efaA:17.093rqlB-3efaA:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eli | AHA1 DOMAIN PROTEIN (Ruegeriapomeroyi) |
PF08327(AHSA1) | 4 | TRP A 84GLU A 96SER A 97VAL A 99 | None | 1.34A | 3rqlA-3eliA:undetectable3rqlB-3eliA:undetectable | 3rqlA-3eliA:15.933rqlB-3eliA:15.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ez0 | UNCHARACTERIZEDPROTEIN WITHFERRITIN-LIKE FOLD (Arthrobactersp. FB24) |
PF13794(MiaE_2) | 4 | GLU A 131SER A 119ARG A 66VAL A 122 | None | 1.32A | 3rqlA-3ez0A:undetectable3rqlB-3ez0A:undetectable | 3rqlA-3ez0A:19.143rqlB-3ez0A:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f4k | PUTATIVEMETHYLTRANSFERASE (Bacteroidesthetaiotaomicron) |
PF13649(Methyltransf_25) | 4 | GLU A 157SER A 156VAL A 175TRP A 153 | None | 1.29A | 3rqlA-3f4kA:undetectable3rqlB-3f4kA:undetectable | 3rqlA-3f4kA:20.653rqlB-3f4kA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fah | ALDEHYDEOXIDOREDUCTASE (Desulfovibriogigas) |
PF00111(Fer2)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2) | 4 | GLU A 545SER A 544MET A 548VAL A 467 | None | 1.34A | 3rqlA-3fahA:undetectable3rqlB-3fahA:undetectable | 3rqlA-3fahA:17.523rqlB-3fahA:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyx | ADENYLYLSULFATEREDUCTASE (Desulfovibriogigas) |
PF00890(FAD_binding_2)PF12139(APS-reductase_C)PF13187(Fer4_9) | 4 | TRP B 88GLU A 380ARG A 66VAL A 387 | None | 1.29A | 3rqlA-3gyxB:undetectable3rqlB-3gyxB:undetectable | 3rqlA-3gyxB:16.673rqlB-3gyxB:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k1u | BETA-XYLOSIDASE,FAMILY 43 GLYCOSYLHYDROLASE (Clostridiumacetobutylicum) |
PF04616(Glyco_hydro_43) | 4 | PHE A 29GLU A 75SER A 262VAL A 275 | None MG A 409 (-3.1A)NoneNone | 1.19A | 3rqlA-3k1uA:undetectable3rqlB-3k1uA:undetectable | 3rqlA-3k1uA:20.973rqlB-3k1uA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2t | LMO2511 PROTEIN (Listeriamonocytogenes) |
PF16321(Ribosom_S30AE_C) | 4 | GLU A 17SER A 15MET A 13VAL A 43 | None | 1.20A | 3rqlA-3k2tA:undetectable3rqlB-3k2tA:undetectable | 3rqlA-3k2tA:13.843rqlB-3k2tA:13.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mga | ENTEROCHELINESTERASE (Salmonellaenterica) |
PF00756(Esterase)PF11806(DUF3327) | 4 | SER A 310ARG A 114VAL A 353TRP A 314 | None | 1.18A | 3rqlA-3mgaA:undetectable3rqlB-3mgaA:undetectable | 3rqlA-3mgaA:21.883rqlB-3mgaA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mga | ENTEROCHELINESTERASE (Salmonellaenterica) |
PF00756(Esterase)PF11806(DUF3327) | 4 | SER A 310ARG A 118VAL A 353TRP A 314 | NoneGOL A 407 ( 4.6A)NoneNone | 0.88A | 3rqlA-3mgaA:undetectable3rqlB-3mgaA:undetectable | 3rqlA-3mgaA:21.883rqlB-3mgaA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o98 | BIFUNCTIONALGLUTATHIONYLSPERMIDINESYNTHETASE/AMIDASE (Escherichiacoli) |
PF03738(GSP_synth)PF05257(CHAP) | 4 | PHE A 75GLU A 83ARG A 64VAL A 132 | NoneNoneTS5 A 620 (-2.3A)None | 1.18A | 3rqlA-3o98A:undetectable3rqlB-3o98A:undetectable | 3rqlA-3o98A:20.853rqlB-3o98A:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3owc | PROBABLEACETYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 4 | PHE A 121GLU A 119ARG A 175VAL A 92 | None | 1.23A | 3rqlA-3owcA:undetectable3rqlB-3owcA:undetectable | 3rqlA-3owcA:16.473rqlB-3owcA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p2c | PUTATIVE GLYCOSYLHYDROLASE (Bacteroidesovatus) |
PF06824(Glyco_hydro_125) | 4 | PHE A 238SER A 267ARG A 240VAL A 249 | None | 1.29A | 3rqlA-3p2cA:undetectable3rqlB-3p2cA:undetectable | 3rqlA-3p2cA:22.033rqlB-3p2cA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3u | LIGNIN PEROXIDASE (Trametopsiscervina) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 4 | TRP A 249PHE A 203MET A 259VAL A 169 | None | 1.29A | 3rqlA-3q3uA:undetectable3rqlB-3q3uA:undetectable | 3rqlA-3q3uA:21.093rqlB-3q3uA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rjy | ENDOGLUCANASEFNCEL5A (Fervidobacteriumnodosum) |
PF00150(Cellulase) | 4 | TRP A 146PHE A 162GLU A 187VAL A 149 | None | 1.26A | 3rqlA-3rjyA:1.53rqlB-3rjyA:undetectable | 3rqlA-3rjyA:21.273rqlB-3rjyA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ti8 | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 4 | PHE A 305GLU A 265VAL A 240TRP A 239 | None | 1.35A | 3rqlA-3ti8A:undetectable3rqlB-3ti8A:undetectable | 3rqlA-3ti8A:22.643rqlB-3ti8A:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uxm | THYMIDYLATE KINASE (Pseudomonasaeruginosa) |
PF02223(Thymidylate_kin) | 4 | PHE A 162GLU A 156ARG A 109VAL A 166 | None MG A 213 (-3.2A)NoneNone | 1.32A | 3rqlA-3uxmA:undetectable3rqlB-3uxmA:undetectable | 3rqlA-3uxmA:20.293rqlB-3uxmA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v7i | PUTATIVE POLYKETIDESYNTHASE (Streptomycescoelicolor) |
PF00195(Chal_sti_synt_N) | 4 | PHE A 353GLU A 203SER A 202VAL A 200 | None | 1.16A | 3rqlA-3v7iA:undetectable3rqlB-3v7iA:undetectable | 3rqlA-3v7iA:20.823rqlB-3v7iA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vx8 | UBIQUITIN-LIKEMODIFIER-ACTIVATINGENZYME ATG7 (Arabidopsisthaliana) |
no annotation | 4 | PHE D 177GLU D 180SER D 212VAL D 208 | None | 1.18A | 3rqlA-3vx8D:undetectable3rqlB-3vx8D:undetectable | 3rqlA-3vx8D:20.523rqlB-3vx8D:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w0s | HYGROMYCIN-B4-O-KINASE (Escherichiacoli) |
PF01636(APH) | 4 | PHE A 136GLU A 219SER A 218TRP A 217 | NoneHY0 A 401 (-4.0A)HY0 A 401 (-3.5A)None | 1.22A | 3rqlA-3w0sA:undetectable3rqlB-3w0sA:undetectable | 3rqlA-3w0sA:19.503rqlB-3w0sA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bgd | PRE-MRNA-SPLICINGFACTOR 8 (Saccharomycescerevisiae) |
PF08084(PROCT) | 4 | TRP C2314PHE C2329GLU C2310VAL C2274 | None | 1.30A | 3rqlA-4bgdC:undetectable3rqlB-4bgdC:undetectable | 3rqlA-4bgdC:20.993rqlB-4bgdC:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ce4 | MRPL44 (Sus scrofa) |
no annotation | 4 | PHE h 196GLU h 127SER h 131ARG h 192 | None | 1.21A | 3rqlA-4ce4h:undetectable3rqlB-4ce4h:undetectable | 3rqlA-4ce4h:20.333rqlB-4ce4h:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4df3 | FIBRILLARIN-LIKERRNA/TRNA2'-O-METHYLTRANSFERASE (Aeropyrumpernix) |
PF01269(Fibrillarin) | 4 | GLU A 109SER A 88MET A 115VAL A 121 | SAM A 301 (-2.9A)NoneNoneNone | 1.31A | 3rqlA-4df3A:undetectable3rqlB-4df3A:undetectable | 3rqlA-4df3A:19.583rqlB-4df3A:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g76 | PHOSPHODIESTERASE (Pseudomonasaeruginosa) |
PF14859(Colicin_M) | 4 | TRP A 62PHE A 85MET A 258VAL A 265 | None | 1.32A | 3rqlA-4g76A:undetectable3rqlB-4g76A:undetectable | 3rqlA-4g76A:19.863rqlB-4g76A:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ia5 | MYOSIN-CROSSREACTIVEANTIGEN (Lactobacillusacidophilus) |
PF06100(MCRA) | 4 | SER A 36MET A 517ARG A 95VAL A 39 | None | 1.25A | 3rqlA-4ia5A:undetectable3rqlB-4ia5A:undetectable | 3rqlA-4ia5A:21.273rqlB-4ia5A:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kdz | TRNA(CYTIDINE(34)-2'-O)-METHYLTRANSFERASE (Escherichiacoli) |
PF00588(SpoU_methylase) | 4 | PHE A 76GLU A 143SER A 87ARG A 74 | None | 1.31A | 3rqlA-4kdzA:undetectable3rqlB-4kdzA:undetectable | 3rqlA-4kdzA:15.093rqlB-4kdzA:15.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l37 | ARYLPHORIN (Bombyx mori) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 4 | PHE B 327GLU B 424VAL B 351TRP B 355 | None | 1.09A | 3rqlA-4l37B:undetectable3rqlB-4l37B:undetectable | 3rqlA-4l37B:20.693rqlB-4l37B:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m9o | BETA-2-MICROGLOBULIN (Danio rerio) |
PF07654(C1-set) | 4 | GLU A 77SER A 92VAL A 9TRP A 93 | None | 1.31A | 3rqlA-4m9oA:undetectable3rqlB-4m9oA:undetectable | 3rqlA-4m9oA:12.623rqlB-4m9oA:12.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mh1 | SORBOSEDEHYDROGENASE (Ketogulonicigeniumvulgare) |
PF13360(PQQ_2) | 4 | TRP A 218PHE A 286ARG A 385TRP A 387 | None | 1.37A | 3rqlA-4mh1A:undetectable3rqlB-4mh1A:undetectable | 3rqlA-4mh1A:21.163rqlB-4mh1A:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n9x | PUTATIVEMONOOXYGENASE (Pectobacteriumatrosepticum) |
PF01494(FAD_binding_3) | 4 | PHE A 101GLU A 97SER A 95VAL A 386 | None | 1.28A | 3rqlA-4n9xA:undetectable3rqlB-4n9xA:undetectable | 3rqlA-4n9xA:22.153rqlB-4n9xA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oro | POLYMERASE PB2 (Influenza Bvirus) |
PF00604(Flu_PB2) | 4 | PHE A 365SER A 407ARG A 334TRP A 359 | NoneNoneGDP A 501 (-4.1A)GDP A 501 (-3.3A) | 1.15A | 3rqlA-4oroA:undetectable3rqlB-4oroA:undetectable | 3rqlA-4oroA:18.213rqlB-4oroA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qiw | DNA-DIRECTED RNAPOLYMERASE SUBUNIT D (Thermococcuskodakarensis) |
PF01000(RNA_pol_A_bac)PF01193(RNA_pol_L) | 4 | GLU D 188SER D 162VAL D 165TRP D 168 | None | 1.17A | 3rqlA-4qiwD:undetectable3rqlB-4qiwD:undetectable | 3rqlA-4qiwD:20.753rqlB-4qiwD:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qo5 | HYPOTHETICALMULTIHEME PROTEIN (Ignicoccushospitalis) |
PF13435(Cytochrome_C554)PF13447(Multi-haem_cyto) | 4 | TRP A 278PHE A 275GLU A 280SER A 281 | HEC A 607 (-4.7A)NoneNoneNone | 1.32A | 3rqlA-4qo5A:2.63rqlB-4qo5A:undetectable | 3rqlA-4qo5A:21.943rqlB-4qo5A:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4udr | GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE (Methylovorussp. MP688) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 4 | GLU A 306SER A 308VAL A 370TRP A 369 | None | 1.27A | 3rqlA-4udrA:undetectable3rqlB-4udrA:undetectable | 3rqlA-4udrA:22.403rqlB-4udrA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xj6 | VC0179-LIKE PROTEIN (Escherichiacoli) |
no annotation | 4 | PHE A 264GLU A 266ARG A 276VAL A 305 | None | 1.15A | 3rqlA-4xj6A:2.23rqlB-4xj6A:undetectable | 3rqlA-4xj6A:21.063rqlB-4xj6A:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xj6 | VC0179-LIKE PROTEIN (Escherichiacoli) |
no annotation | 4 | TRP A 263PHE A 264GLU A 266VAL A 305 | None | 1.09A | 3rqlA-4xj6A:2.23rqlB-4xj6A:undetectable | 3rqlA-4xj6A:21.063rqlB-4xj6A:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z48 | UNCHARACTERIZEDPROTEIN (Desulfovibriopiger) |
PF17131(LolA_like) | 4 | SER A 105ARG A 127VAL A 103TRP A 104 | None | 1.00A | 3rqlA-4z48A:undetectable3rqlB-4z48A:undetectable | 3rqlA-4z48A:21.293rqlB-4z48A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zva | DIGUANYLATE CYCLASEDOSC (Escherichiacoli) |
PF11563(Protoglobin) | 4 | TRP A 12GLU A 11MET A 8VAL A 84 | None | 1.32A | 3rqlA-4zvaA:undetectable3rqlB-4zvaA:undetectable | 3rqlA-4zvaA:18.863rqlB-4zvaA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bni | UNCHARACTERIZEDPROTEIN (Sus scrofa) |
PF02267(Rib_hydrolayse) | 4 | PHE A 94SER A 163VAL A 189TRP A 193 | None | 1.34A | 3rqlA-5bniA:undetectable3rqlB-5bniA:undetectable | 3rqlA-5bniA:20.953rqlB-5bniA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by3 | BTGH115A (Bacteroidesthetaiotaomicron) |
PF15979(Glyco_hydro_115) | 4 | TRP A 732GLU A 731ARG A 505VAL A 736 | None | 1.37A | 3rqlA-5by3A:undetectable3rqlB-5by3A:undetectable | 3rqlA-5by3A:19.823rqlB-5by3A:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c2v | HYDRAZINE SYNTHASEALPHA SUBUNIT (CandidatusKueneniastuttgartiensis) |
no annotation | 4 | PHE A 206SER A 254ARG A 518VAL A 271 | None | 1.12A | 3rqlA-5c2vA:undetectable3rqlB-5c2vA:undetectable | 3rqlA-5c2vA:18.003rqlB-5c2vA:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f5w | GLYCINE--TRNA LIGASEALPHA SUBUNIT (Aquifexaeolicus) |
PF02091(tRNA-synt_2e) | 4 | GLU A 217SER A 220ARG A 269VAL A 224 | None | 1.31A | 3rqlA-5f5wA:undetectable3rqlB-5f5wA:undetectable | 3rqlA-5f5wA:21.383rqlB-5f5wA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f9q | MACROLIDE EXPORTATP-BINDING/PERMEASEPROTEIN YKNZ (Bacillusamyloliquefaciens) |
PF12704(MacB_PCD) | 4 | PHE A 123SER A 115MET A 160VAL A 145 | None | 1.31A | 3rqlA-5f9qA:2.13rqlB-5f9qA:undetectable | 3rqlA-5f9qA:19.863rqlB-5f9qA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gje | LOW-DENSITYLIPOPROTEINRECEPTOR-RELATEDPROTEIN 6 (Homo sapiens) |
PF00058(Ldl_recept_b)PF14670(FXa_inhibition) | 4 | PHE B 633SER B 884ARG B 644VAL B 671 | None | 1.26A | 3rqlA-5gjeB:undetectable3rqlB-5gjeB:undetectable | 3rqlA-5gjeB:20.073rqlB-5gjeB:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iwz | SYNAPTONEMAL COMPLEXPROTEIN 2 (Mus musculus) |
no annotation | 4 | TRP A 239PHE A 249GLU A 205SER A 201 | None | 1.10A | 3rqlA-5iwzA:2.03rqlB-5iwzA:undetectable | 3rqlA-5iwzA:22.003rqlB-5iwzA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jmv | PROBABLEBIFUNCTIONAL TRNATHREONYLCARBAMOYLADENOSINE BIOSYNTHESISPROTEINUNCHARACTERIZEDPROTEIN (Methanocaldococcusjannaschii;Pyrococcusfuriosus) |
PF00814(Peptidase_M22)PF09341(Pcc1) | 4 | SER A 82ARG A 91VAL A 85TRP D 72 | None | 1.36A | 3rqlA-5jmvA:undetectable3rqlB-5jmvA:undetectable | 3rqlA-5jmvA:21.233rqlB-5jmvA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kn8 | ADENINE DNAGLYCOSYLASE (Geobacillusstearothermophilus) |
PF00633(HHH)PF00730(HhH-GPD) | 4 | TRP A 83PHE A 61GLU A 84VAL A 92 | None | 1.34A | 3rqlA-5kn8A:undetectable3rqlB-5kn8A:undetectable | 3rqlA-5kn8A:22.283rqlB-5kn8A:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8t | 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACIDOXIDASE (Homo sapiens) |
PF00264(Tyrosinase) | 4 | TRP A 414PHE A 411GLU A 413ARG A 225 | None | 1.07A | 3rqlA-5m8tA:undetectable3rqlB-5m8tA:undetectable | 3rqlA-5m8tA:20.003rqlB-5m8tA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqz | PUTATIVEBRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE (Archaeoglobusfulgidus) |
no annotation | 4 | PHE A 43GLU A 282SER A 278ARG A 44 | None | 1.37A | 3rqlA-5mqzA:undetectable3rqlB-5mqzA:undetectable | 3rqlA-5mqzA:15.183rqlB-5mqzA:15.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ovu | BETA-PROTEOBACTERIAPROTEASOME HOMOLOGUE (Cupriavidusmetallidurans) |
no annotation | 4 | PHE A 80GLU A 126SER A 123VAL A 109 | None | 1.25A | 3rqlA-5ovuA:undetectable3rqlB-5ovuA:undetectable | 3rqlA-5ovuA:10.293rqlB-5ovuA:10.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tul | TETRACYCLINEDESTRUCTASE TET(55) (unculturedbacterium) |
PF01494(FAD_binding_3) | 4 | TRP A 346PHE A 343GLU A 349SER A 350 | None | 1.23A | 3rqlA-5tulA:1.53rqlB-5tulA:undetectable | 3rqlA-5tulA:21.553rqlB-5tulA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2n | NICOTINAMIDEPHOSPHORIBOSYLTRANSFERASE (Homo sapiens) |
PF04095(NAPRTase) | 4 | PHE A 132GLU A 38SER A 398VAL A 153 | NoneNoneSO4 A 502 (-2.8A)None | 1.36A | 3rqlA-5u2nA:undetectable3rqlB-5u2nA:undetectable | 3rqlA-5u2nA:20.573rqlB-5u2nA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w62 | APOPTOSIS REGULATORBAX (Mus musculus) |
no annotation | 4 | PHE A 30GLU A 61SER A 62ARG A 34 | None | 1.23A | 3rqlA-5w62A:1.83rqlB-5w62A:undetectable | 3rqlA-5w62A:11.753rqlB-5w62A:11.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wly | UDP-2,3-DIACYLGLUCOSAMINE HYDROLASE (Escherichiacoli) |
no annotation | 4 | TRP A 219GLU A 222SER A 224ARG A 24 | None | 1.15A | 3rqlA-5wlyA:undetectable3rqlB-5wlyA:undetectable | 3rqlA-5wlyA:13.323rqlB-5wlyA:13.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x89 | ENDA-LIKEPROTEIN,TRNA-SPLICING ENDONUCLEASE (Methanopyruskandleri) |
no annotation | 4 | PHE A 258GLU A 253MET A 249VAL A 231 | None | 0.96A | 3rqlA-5x89A:undetectable3rqlB-5x89A:undetectable | 3rqlA-5x89A:12.703rqlB-5x89A:12.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xf7 | PROTEINDISULFIDE-ISOMERASE-LIKE PROTEIN OF THETESTIS (Homo sapiens) |
no annotation | 4 | PHE A 113GLU A 106ARG A 129VAL A 65 | None | 1.23A | 3rqlA-5xf7A:undetectable3rqlB-5xf7A:undetectable | 3rqlA-5xf7A:10.853rqlB-5xf7A:10.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgp | SECRETED XWNT8INHIBITOR SIZZLED (Xenopus laevis) |
PF01392(Fz) | 4 | PHE A 180GLU A 222VAL A 254TRP A 224 | None | 0.87A | 3rqlA-5xgpA:undetectable3rqlB-5xgpA:undetectable | 3rqlA-5xgpA:19.673rqlB-5xgpA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xwd | VH CHAIN OF 059-152VL CHAIN OF 059-152 (Homo sapiens) |
no annotation | 4 | TRP H 49MET H 105VAL D 98TRP D 91 | None | 1.19A | 3rqlA-5xwdH:undetectable3rqlB-5xwdH:undetectable | 3rqlA-5xwdH:9.593rqlB-5xwdH:9.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bk1 | UDP-GLYCOSYLTRANSFERASE 79 (Oryza sativa) |
no annotation | 4 | GLU A 322ARG A 331VAL A 317TRP A 316 | NoneNoneUDP A 501 ( 4.8A)None | 1.27A | 3rqlA-6bk1A:undetectable3rqlB-6bk1A:undetectable | 3rqlA-6bk1A:13.483rqlB-6bk1A:13.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cri | - (-) |
no annotation | 4 | GLU M 193SER M 192ARG M 421VAL M 189 | None | 1.19A | 3rqlA-6criM:undetectable3rqlB-6criM:undetectable | 3rqlA-6criM:undetectable3rqlB-6criM:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eux | POLYMERASE BASICPROTEIN 2 (Influenza Bvirus) |
no annotation | 4 | PHE A 365SER A 407ARG A 334TRP A 359 | NoneNoneBYB A 601 ( 4.8A)BYB A 601 (-3.4A) | 1.37A | 3rqlA-6euxA:undetectable3rqlB-6euxA:undetectable | 3rqlA-6euxA:11.423rqlB-6euxA:11.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fn1 | HUMAN-MOUSE CHIMERICABCB1 (ABCBHM) (Homo sapiens) |
no annotation | 4 | PHE A 78GLU A 971SER A 969VAL A 963 | None | 1.33A | 3rqlA-6fn1A:2.83rqlB-6fn1A:undetectable | 3rqlA-6fn1A:14.603rqlB-6fn1A:14.60 |