SIMILAR PATTERNS OF AMINO ACIDS FOR 3ROZ_A_NCAA266

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA

(Rattus
norvegicus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ASP A 116
ALA A 139
ASP A 137
THR A 143
 None
 0.93A 3rozA-1ed3A:
undetectable		 3rozA-1ed3A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jax CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF03807
(F420_oxidored) 		4 LEU A  16
ALA A  68
LEU A   6
THR A  71
 None
 1.00A 3rozA-1jaxA:
4.1		 3rozA-1jaxA:
23.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jzt HYPOTHETICAL 27.5
KDA PROTEIN IN
SPX19-GCR2
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF03853
(YjeF_N) 		6 ASP A  16
LEU A  19
ALA A  35
ASP A  73
LEU A 198
THR A 199
 None
 0.47A 3rozA-1jztA:
34.6		 3rozA-1jztA:
39.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus) 		PF00962
(A_deaminase) 		4 LEU A 233
ALA A 276
LEU A 240
THR A 239
 None
 0.93A 3rozA-1krmA:
undetectable		 3rozA-1krmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw5 NAGD PROTEIN,
PUTATIVE

(Thermotoga
maritima) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 LEU A  98
ALA A 162
ASP A 161
THR A 146
 None
 0.86A 3rozA-1pw5A:
3.3		 3rozA-1pw5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz1 GENERAL STRESS
PROTEIN 69

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		4 LEU A 121
ALA A   7
ASP A   8
THR A 173
 None
 1.09A 3rozA-1pz1A:
2.0		 3rozA-1pz1A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaz ARCHAERHODOPSIN-1

(Halorubrum
chaoviator) 		PF01036
(Bac_rhodopsin) 		4 ASP A  11
ALA A   6
LEU A   8
THR A  16
 None
 1.07A 3rozA-1uazA:
undetectable		 3rozA-1uazA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvm TOXIN B

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 LEU A   9
ALA A  26
LEU A  55
THR A  56
 None
 0.98A 3rozA-2bvmA:
1.1		 3rozA-2bvmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu6 DTDP-4-KETO-L-RHAMNO
SE REDUCTASE-RELATED
PROTEIN

(Thermus
thermophilus) 		PF01883
(FeS_assembly_P) 		5 ASP A  20
LEU A  30
ASP A  58
LEU A  49
THR A  50
 None
 1.39A 3rozA-2cu6A:
undetectable		 3rozA-2cu6A:
17.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dg2 APOLIPOPROTEIN A-I
BINDING PROTEIN

(Mus musculus) 		PF03853
(YjeF_N) 		6 ASP A  39
LEU A  42
ALA A  57
ASP A  93
LEU A 211
THR A 212
 None
 0.36A 3rozA-2dg2A:
42.5		 3rozA-2dg2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B

(Pyrococcus
horikoshii) 		PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 LEU A 157
ALA A  36
LEU A 161
THR A 128
 None
 1.01A 3rozA-2dplA:
3.6		 3rozA-2dplA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE

(Sulfurisphaera
tokodaii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ALA A 239
ASP A 178
LEU A 222
THR A 218
 None
 1.09A 3rozA-2f7lA:
3.8		 3rozA-2f7lA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyx PROTEIN DIPZ

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 LEU A 629
ALA A 633
LEU A 567
THR A 568
 None
 1.05A 3rozA-2hyxA:
undetectable		 3rozA-2hyxA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9w HYPOTHETICAL PROTEIN

(Psychrobacter
arcticus) 		PF02810
(SEC-C) 		4 LEU A  83
ALA A  78
LEU A  76
THR A  75
 None
 0.97A 3rozA-2i9wA:
undetectable		 3rozA-2i9wA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igt SAM DEPENDENT
METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF10672
(Methyltrans_SAM) 		4 LEU A 230
ALA A 191
LEU A 139
THR A 210
 None
SAM  A1001 (-3.6A)
None
None
 1.01A 3rozA-2igtA:
5.7		 3rozA-2igtA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 473
ALA A 461
ASP A 409
THR A 485
 None
 1.08A 3rozA-2ihtA:
undetectable		 3rozA-2ihtA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mt9 FLAVODOXIN-2

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		4 ASP A  38
LEU A  35
ALA A  18
LEU A  32
 None
 1.12A 3rozA-2mt9A:
3.5		 3rozA-2mt9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nps VESICLE-ASSOCIATED
MEMBRANE PROTEIN 4
VESICLE TRANSPORT
THROUGH INTERACTION
WITH T-SNARES
HOMOLOG 1A
SYNTAXIN-6

(Mus musculus;
Rattus
norvegicus;
Homo sapiens) 		PF00957
(Synaptobrevin)
PF12352
(V-SNARE_C)
no annotation 		4 ASP C 171
LEU C 167
ALA A  96
LEU D 215
 None
 0.95A 3rozA-2npsC:
undetectable		 3rozA-2npsC:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxo HYPOTHETICAL PROTEIN
SCO4506

(Streptomyces
coelicolor) 		PF02621
(VitK2_biosynth) 		4 ASP A 151
LEU A 154
ALA A 227
LEU A  18
 None
 1.03A 3rozA-2nxoA:
undetectable		 3rozA-2nxoA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qed HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		4 ASP A  93
LEU A 104
ALA A  78
LEU A  88
 None
 0.91A 3rozA-2qedA:
undetectable		 3rozA-2qedA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlc DNA REPAIR PROTEIN
RADC HOMOLOG

(Chlorobaculum
tepidum) 		PF04002
(RadC) 		4 ALA A  87
ASP A  88
LEU A  49
THR A  48
 None
 1.00A 3rozA-2qlcA:
undetectable		 3rozA-2qlcA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		4 ASP A 129
LEU A 172
ALA A 136
ASP A  64
 None
 1.00A 3rozA-2qt3A:
undetectable		 3rozA-2qt3A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri8 MANNOSYL-OLIGOSACCHA
RIDE
ALPHA-1,2-MANNOSIDAS
E

(Penicillium
citrinum) 		PF01532
(Glyco_hydro_47) 		4 LEU A1162
ALA A1081
ASP A1063
THR A1123
 None
 1.01A 3rozA-2ri8A:
undetectable		 3rozA-2ri8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tpt THYMIDINE
PHOSPHORYLASE

(Escherichia
coli) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 LEU A 246
ALA A 278
LEU A 238
THR A 240
 None
 1.10A 3rozA-2tptA:
undetectable		 3rozA-2tptA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 LEU A   9
ALA A  26
LEU A  55
THR A  56
 None
 1.01A 3rozA-2vl8A:
undetectable		 3rozA-2vl8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 ASP A1214
LEU A1211
LEU A1362
THR A1363
 None
 0.83A 3rozA-2vz9A:
undetectable		 3rozA-2vz9A:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 ASP A 246
LEU A 105
ALA A 315
LEU A 249
 None
 1.06A 3rozA-2yheA:
undetectable		 3rozA-2yheA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1

(Homo sapiens) 		PF01380
(SIS) 		4 LEU A 368
ALA A 488
LEU A 390
THR A 391
 None
 1.04A 3rozA-2zj4A:
3.7		 3rozA-2zj4A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		4 ASP A 143
LEU A 144
ALA A 370
THR A 112
 None
 1.10A 3rozA-3a1iA:
undetectable		 3rozA-3a1iA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 250
ASP A 229
LEU A 231
THR A 232
 None
 0.99A 3rozA-3bjsA:
undetectable		 3rozA-3bjsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9h ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		4 ASP A  43
LEU A  46
ALA A 239
LEU A 220
 MG  A 401 ( 3.2A)
None
None
None
 1.11A 3rozA-3c9hA:
undetectable		 3rozA-3c9hA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czm L-LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ASP A  66
LEU A  51
ALA A 251
LEU A  39
 None
 1.10A 3rozA-3czmA:
undetectable		 3rozA-3czmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewk SENSOR PROTEIN

(Methylococcus
capsulatus) 		PF13426
(PAS_9) 		4 ALA A 262
ASP A 258
LEU A 267
THR A 266
 None
 1.04A 3rozA-3ewkA:
undetectable		 3rozA-3ewkA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7w PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Thermobifida
fusca) 		PF03881
(Fructosamin_kin) 		4 LEU A  41
ASP A  82
LEU A  11
THR A  12
 None
 1.09A 3rozA-3f7wA:
undetectable		 3rozA-3f7wA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5o TRANSCRIPTIONAL
REGULATOR GNTR

(Chromobacterium
violaceum) 		PF13377
(Peripla_BP_3) 		4 LEU A 181
ALA A 259
ASP A 256
LEU A 295
 None
 1.00A 3rozA-3h5oA:
3.6		 3rozA-3h5oA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 LEU A  63
ALA A 415
LEU A  95
THR A  96
 None
 0.96A 3rozA-3hwwA:
undetectable		 3rozA-3hwwA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyj PROTEIN DUF199/WHIA

(Thermotoga
maritima) 		PF10298
(WhiA_N)
PF14527
(LAGLIDADG_WhiA) 		4 LEU A 138
ALA A 159
LEU A 151
THR A 147
 None
 1.04A 3rozA-3hyjA:
undetectable		 3rozA-3hyjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum) 		PF00291
(PALP) 		4 LEU A  69
ALA A 343
ASP A  83
LEU A 314
 None
 1.06A 3rozA-3iauA:
2.9		 3rozA-3iauA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9c TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF13377
(Peripla_BP_3) 		4 LEU A 215
ALA A 247
LEU A 180
THR A 181
 None
 0.98A 3rozA-3k9cA:
3.3		 3rozA-3k9cA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la2 GLOBAL NITROGEN
REGULATOR

(Nostoc sp. PCC
7120) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 ASP A 159
LEU A 156
ALA A  67
LEU A  69
 None
 1.12A 3rozA-3la2A:
undetectable		 3rozA-3la2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 ASP A 305
LEU A 329
ALA A 171
THR A 175
 GLU  A 506 (-2.7A)
None
None
GLU  A 506 (-3.0A)
 1.12A 3rozA-3lmkA:
4.8		 3rozA-3lmkA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3md0 ARGININE/ORNITHINE
TRANSPORT SYSTEM
ATPASE

(Mycobacterium
tuberculosis) 		PF03308
(ArgK) 		4 ASP A 288
LEU A 285
ALA A 167
LEU A 132
 None
 1.11A 3rozA-3md0A:
undetectable		 3rozA-3md0A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ALA A 296
ASP A 294
LEU A  75
THR A 125
 None
 1.02A 3rozA-3nwrA:
undetectable		 3rozA-3nwrA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aspergillus
nidulans) 		PF01179
(Cu_amine_oxid)
PF09248
(DUF1965) 		4 ALA A 264
ASP A 327
LEU A 274
THR A 272
 None
 1.12A 3rozA-3pgbA:
undetectable		 3rozA-3pgbA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 ASP A 654
LEU A 653
ALA A 136
THR A 324
 None
 1.12A 3rozA-3pvcA:
4.1		 3rozA-3pvcA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2h BACTERIOFERRITIN

(Pseudomonas
aeruginosa) 		PF00210
(Ferritin) 		4 ASP A  74
ALA A  99
LEU A  14
THR A  13
 CXS  A 155 (-3.7A)
None
None
None
 1.09A 3rozA-3r2hA:
undetectable		 3rozA-3r2hA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3soz CYTOPLASMIC PROTEIN
STM1381

(Salmonella
enterica) 		PF07090
(GATase1_like) 		4 ASP A  96
LEU A  82
LEU A 134
THR A 132
 None
 1.08A 3rozA-3sozA:
3.7		 3rozA-3sozA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 460
LEU A 459
ALA A  81
LEU A 113
 None
GOL  A 508 (-4.6A)
GOL  A 508 (-4.2A)
None
 1.08A 3rozA-3t6wA:
undetectable		 3rozA-3t6wA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE

(Acetobacter
aceti) 		PF02515
(CoA_transf_3) 		4 ASP A 412
LEU A 415
ASP A 430
THR A 434
 None
 0.86A 3rozA-3ubmA:
4.1		 3rozA-3ubmA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9o DIHYDRONEOPTERIN
ALDOLASE

(Burkholderia
thailandensis) 		PF02152
(FolB) 		4 LEU A  21
ALA A 106
LEU A  57
THR A  58
 None
 1.01A 3rozA-3v9oA:
undetectable		 3rozA-3v9oA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ASP A 291
LEU A 314
ALA A 363
LEU A 295
 None
 1.08A 3rozA-3vf1A:
undetectable		 3rozA-3vf1A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 LEU A 392
ALA A 431
ASP A 428
THR A 435
 None
 1.12A 3rozA-3wfoA:
undetectable		 3rozA-3wfoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 ASP A 221
LEU A 222
ALA A 157
LEU A 187
 None
 1.06A 3rozA-3wiqA:
undetectable		 3rozA-3wiqA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 LEU A 699
ALA A 643
ASP A 644
LEU A 687
 None
 1.03A 3rozA-4a4zA:
undetectable		 3rozA-4a4zA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 LEU A 286
ASP A 227
LEU A  42
THR A  41
 None
MG  A1663 ( 4.0A)
None
None
 1.12A 3rozA-4c30A:
undetectable		 3rozA-4c30A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6b CITRATE SYNTHASE

(Escherichia
coli) 		PF00285
(Citrate_synt) 		4 ASP A 334
LEU A 335
ALA A 371
LEU A 329
 None
 1.08A 3rozA-4g6bA:
undetectable		 3rozA-4g6bA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 ASP M 114
LEU M 176
ALA M  59
LEU M  56
 None
 1.06A 3rozA-4heaM:
undetectable		 3rozA-4heaM:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn3 LMO1757 PROTEIN

(Listeria
monocytogenes) 		PF07537
(CamS) 		4 ASP A 189
LEU A 192
ALA A 238
ASP A 252
 None
 0.98A 3rozA-4hn3A:
undetectable		 3rozA-4hn3A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7

(Clostridioides
difficile) 		PF00877
(NLPC_P60)
PF13702
(Lysozyme_like) 		4 LEU A 281
ALA A 221
LEU A 245
THR A 246
 None
None
OCS  A 242 ( 4.4A)
OCS  A 242 ( 3.4A)
 1.12A 3rozA-4hpeA:
undetectable		 3rozA-4hpeA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 316
ALA A 334
LEU A  62
THR A  63
 None
 1.07A 3rozA-4iigA:
undetectable		 3rozA-4iigA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7m PROTEIN DOM3Z

(Mus musculus) 		PF08652
(RAI1) 		4 LEU A 135
ALA A 153
LEU A 160
THR A 128
 None
 1.07A 3rozA-4j7mA:
undetectable		 3rozA-4j7mA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		4 LEU A 477
ALA A 494
ASP A 448
THR A 453
 None
 1.03A 3rozA-4k5rA:
4.2		 3rozA-4k5rA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		4 LEU A 721
ALA A 811
LEU A 796
THR A 792
 None
 0.96A 3rozA-4kf7A:
undetectable		 3rozA-4kf7A:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk6 PROBABLE
DIHYDROXYACETONE
KINASE REGULATOR
DHSK_REG

(Listeria
monocytogenes) 		PF00440
(TetR_N)
PF14278
(TetR_C_8) 		4 LEU A 168
ALA A  67
LEU A 111
THR A 112
 None
 1.11A 3rozA-4mk6A:
undetectable		 3rozA-4mk6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx8 PERIPLASMIC BINDING
PROTEIN

(Xylanimonas
cellulosilytica) 		PF01497
(Peripla_BP_2) 		4 LEU A 139
ALA A  53
ASP A  51
THR A  57
 None
 1.09A 3rozA-4mx8A:
undetectable		 3rozA-4mx8A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 LEU A 534
ALA A 460
LEU A 504
THR A 458
 None
 1.03A 3rozA-4okdA:
undetectable		 3rozA-4okdA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p08 COCAINE ESTERASE

(Rhodococcus sp.
MB1) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 LEU A 378
ALA A 369
ASP A 389
LEU A 428
 None
 1.01A 3rozA-4p08A:
undetectable		 3rozA-4p08A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph6 3-DEHYDROQUINATE
DEHYDRATASE

(Enterococcus
faecalis) 		PF01487
(DHquinase_I) 		4 LEU A 246
ALA A 222
LEU A 223
THR A 224
 None
 0.99A 3rozA-4ph6A:
undetectable		 3rozA-4ph6A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00266
(Aminotran_5) 		4 LEU A 196
ALA A 184
LEU A 133
THR A 134
 None
 1.06A 3rozA-4q76A:
undetectable		 3rozA-4q76A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus) 		PF01546
(Peptidase_M20) 		4 ASP A 305
LEU A  69
ALA A  96
ASP A  95
 None
 0.95A 3rozA-4q7aA:
undetectable		 3rozA-4q7aA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9n LMO0547 PROTEIN

(Listeria
monocytogenes) 		PF04198
(Sugar-bind) 		4 ASP A 298
LEU A  74
ALA A 294
LEU A 296
 None
 1.05A 3rozA-4r9nA:
undetectable		 3rozA-4r9nA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA

(Escherichia
coli) 		PF03611
(EIIC-GAT) 		4 LEU A  62
ALA A 316
ASP A 314
LEU A  55
 None
ASC  A 501 ( 3.7A)
ASC  A 501 (-2.7A)
None
 1.10A 3rozA-4rp8A:
undetectable		 3rozA-4rp8A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxt SUGAR ABC
TRANSPORTER

(Agrobacterium
tumefaciens) 		PF13407
(Peripla_BP_4) 		4 ASP A 216
LEU A 217
ALA A 241
LEU A 211
 None
 1.00A 3rozA-4rxtA:
4.6		 3rozA-4rxtA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utt PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Clostridium
perfringens) 		PF04131
(NanE) 		4 ASP A 194
LEU A 195
ALA A 200
LEU A 189
 None
 1.07A 3rozA-4uttA:
undetectable		 3rozA-4uttA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6v DI-/TRIPEPTIDE
TRANSPORTER

(Yersinia
enterocolitica) 		PF00854
(PTR2) 		4 ASP A 324
LEU A 320
ALA A  47
ASP A  51
 None
 1.02A 3rozA-4w6vA:
undetectable		 3rozA-4w6vA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcg THERMOSOME SUBUNIT
BETA

(Sulfolobus
solfataricus) 		PF00118
(Cpn60_TCP1) 		4 LEU B  78
ALA B 103
ASP B 402
THR B 106
 None
 1.00A 3rozA-4xcgB:
undetectable		 3rozA-4xcgB:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybn FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN

(Mycolicibacterium
smegmatis) 		PF12900
(Pyridox_ox_2) 		4 ASP A  28
ALA A  86
ASP A  88
THR A  32
 None
 0.97A 3rozA-4ybnA:
undetectable		 3rozA-4ybnA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgy ORNITHINE
DECARBOXYLASE
ANTIZYME 1

(Homo sapiens) 		PF02100
(ODC_AZ) 		4 LEU B 159
ASP B  98
LEU B 116
THR B 132
 None
 1.11A 3rozA-4zgyB:
undetectable		 3rozA-4zgyB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2b 3B4 LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 ALA L   3
ASP L  28
LEU L   4
THR L   5
 None
 0.91A 3rozA-5c2bL:
undetectable		 3rozA-5c2bL:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diz PROTEINACEOUS RNASE
P 2

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		4 LEU A  34
ALA A  49
LEU A  75
THR A  71
 None
 1.10A 3rozA-5dizA:
undetectable		 3rozA-5dizA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 LEU A 107
ALA A  53
LEU A 132
THR A 133
 None
 1.12A 3rozA-5ez3A:
undetectable		 3rozA-5ez3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A  51
ALA A 148
LEU A  61
THR A  62
 None
 1.03A 3rozA-5g3fA:
undetectable		 3rozA-5g3fA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwe CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		4 LEU A 408
ALA A 413
LEU A 300
THR A 297
 HEM  A 501 ( 4.7A)
None
HEM  A 501 ( 4.7A)
HEM  A 501 (-3.6A)
 1.04A 3rozA-5gweA:
undetectable		 3rozA-5gweA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6s AMIDASE

(Microbacterium
sp. HM58-2) 		PF01425
(Amidase) 		4 ASP A 392
ALA A 141
LEU A 389
THR A 151
 None
 1.06A 3rozA-5h6sA:
undetectable		 3rozA-5h6sA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioo AVPA

(Nanoarchaeota
archaeon JGI
OTU-1) 		no annotation 4 ASP A 173
ALA A  95
LEU A 180
THR A  61
 None
 1.12A 3rozA-5iooA:
undetectable		 3rozA-5iooA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 313
ALA A 331
LEU A  62
THR A  63
 None
 1.08A 3rozA-5ju6A:
undetectable		 3rozA-5ju6A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kin TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN

(Streptococcus
pneumoniae;
Streptococcus
pneumoniae) 		PF00290
(Trp_syntA)
PF00291
(PALP) 		4 ASP A  59
LEU B 284
ASP B 294
LEU B 300
 None
 0.98A 3rozA-5kinA:
undetectable		 3rozA-5kinA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvk PROTEIN KP700603

(Klebsiella
pneumoniae) 		PF02464
(CinA) 		4 LEU A  41
ALA A 160
LEU A  15
THR A  16
 None
 1.04A 3rozA-5kvkA:
undetectable		 3rozA-5kvkA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldt MOMP PORIN

(Campylobacter
jejuni) 		PF05538
(Campylo_MOMP) 		4 LEU A 310
ALA A 234
ASP A 216
LEU A 296
 None
 1.07A 3rozA-5ldtA:
undetectable		 3rozA-5ldtA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 PROTEASOME SUBUNIT
BETA TYPE-2

(Homo sapiens) 		PF00227
(Proteasome) 		4 LEU J 104
ALA J 122
LEU J  88
THR J  84
 None
 1.10A 3rozA-5m32J:
undetectable		 3rozA-5m32J:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr6 XIAF PROTEIN

(Streptomyces
sp.) 		PF08028
(Acyl-CoA_dh_2) 		4 LEU A  97
ALA A 238
LEU A 307
THR A 234
 None
 1.09A 3rozA-5mr6A:
undetectable		 3rozA-5mr6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA

(Escherichia
coli) 		no annotation 4 ASP E 222
LEU E 226
LEU E  56
THR E  54
 None
 1.06A 3rozA-5ng5E:
undetectable		 3rozA-5ng5E:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5noa FAMILY 88 GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF07470
(Glyco_hydro_88) 		4 ASP A 193
LEU A 189
ASP A 229
LEU A 260
 None
 0.83A 3rozA-5noaA:
undetectable		 3rozA-5noaA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		4 LEU A 413
ALA A 332
LEU A 379
THR A 380
 None
 1.04A 3rozA-5ujuA:
4.2		 3rozA-5ujuA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjn CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		4 LEU A 381
ALA A 386
LEU A 273
THR A 270
 HEM  A 502 ( 4.0A)
None
HEM  A 502 (-2.8A)
HEM  A 502 (-3.6A)
 1.10A 3rozA-5xjnA:
undetectable		 3rozA-5xjnA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoy [LYSW]-LYSINE
HYDROLASE

(Thermus
thermophilus) 		PF01546
(Peptidase_M20) 		4 ASP A 302
LEU A  65
ALA A  92
ASP A  91
 None
 0.97A 3rozA-5xoyA:
undetectable		 3rozA-5xoyA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 ASP A2204
LEU A2171
ALA A2180
LEU A2210
 None
 1.10A 3rozA-5y4dA:
undetectable		 3rozA-5y4dA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zhz PROBABLE
ENDONUCLEASE 4

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A 161
ALA A 132
ASP A 204
THR A 166
 None
None
ZN  A 306 ( 1.9A)
None
 1.10A 3rozA-5zhzA:
undetectable		 3rozA-5zhzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brm PUTATIVE
METAL-DEPENDENT
ISOTHIOCYANATE
HYDROLASE SAXA

(Pectobacterium
carotovorum) 		no annotation 4 LEU A 185
ALA A 215
LEU A 212
THR A 208
 None
 0.92A 3rozA-6brmA:
undetectable		 3rozA-6brmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co9 PROBABLE
COA-TRANSFERASE BETA
SUBUNIT

(Rhodococcus
jostii) 		no annotation 4 LEU B 236
ALA B  19
ASP B  20
THR B  47
 None
 1.11A 3rozA-6co9B:
3.4		 3rozA-6co9B:
undetectable