SIMILAR PATTERNS OF AMINO ACIDS FOR 3ROX_A_TEPA266_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R) 		PF00285
(Citrate_synt) 		4 ALA A 175
VAL A 178
LEU A 182
LEU A 286
 None
 0.72A 3roxA-1a59A:
undetectable		 3roxA-1a59A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amk TRIOSE PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00121
(TIM) 		4 ALA A 183
VAL A 186
LEU A 190
LEU A 209
 None
 0.59A 3roxA-1amkA:
undetectable		 3roxA-1amkA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bfo CAMPATH-1G ANTIBODY

(Rattus rattus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA A  84
VAL A  83
ASP A  82
LEU A  78
LEU A  73
 None
 1.49A 3roxA-1bfoA:
undetectable		 3roxA-1bfoA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c41 LUMAZINE SYNTHASE

(Magnaporthe
grisea) 		PF00885
(DMRL_synthase) 		4 ALA A 132
VAL A 135
LEU A 139
LEU A 155
 None
 0.70A 3roxA-1c41A:
2.4		 3roxA-1c41A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 ALA A 517
VAL A 520
LEU A 524
LEU A 540
 None
 0.56A 3roxA-1c4kA:
3.3		 3roxA-1c4kA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 ALA C 209
ASP C 205
LEU C 252
THR C 251
 None
 0.79A 3roxA-1d7wC:
undetectable		 3roxA-1d7wC:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 VAL A 207
ASP A 208
LEU A 211
ASP A 639
 None
 0.82A 3roxA-1dedA:
undetectable		 3roxA-1dedA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		4 ALA A 122
VAL A 167
ASP A 120
LEU A 117
 None
 0.83A 3roxA-1dj2A:
2.5		 3roxA-1dj2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm0 SHIGA TOXIN A
SUBUNIT

(Shigella
dysenteriae) 		PF00161
(RIP) 		4 ALA A 194
VAL A 197
ASP A 198
LEU A 201
 None
 0.74A 3roxA-1dm0A:
undetectable		 3roxA-1dm0A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqu ISOCITRATE LYASE

(Aspergillus
nidulans) 		PF00463
(ICL) 		4 ALA A 507
VAL A 510
ASP A 511
LEU A 514
 None
 0.41A 3roxA-1dquA:
undetectable		 3roxA-1dquA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em8 DNA POLYMERASE III
PSI SUBUNIT

(Escherichia
coli) 		PF03603
(DNA_III_psi) 		4 ALA B  60
VAL B  57
ASP B  56
LEU B  53
 None
 0.79A 3roxA-1em8B:
undetectable		 3roxA-1em8B:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv CYTOCHROME C1

(Saccharomyces
cerevisiae) 		PF02167
(Cytochrom_C1) 		4 ALA D 248
VAL D 251
LEU D 255
LEU D 194
 None
 0.78A 3roxA-1ezvD:
undetectable		 3roxA-1ezvD:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		4 ALA A 619
VAL A 622
LEU A 626
LEU A 505
 None
 0.73A 3roxA-1fbwA:
undetectable		 3roxA-1fbwA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 VAL A 417
LEU A 421
LEU A 402
THR A 401
 None
 0.76A 3roxA-1hn0A:
undetectable		 3roxA-1hn0A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hrd GLUTAMATE
DEHYDROGENASE

([Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ALA A 395
VAL A 398
ASP A 399
LEU A 402
 None
 0.48A 3roxA-1hrdA:
6.5		 3roxA-1hrdA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 ALA A  39
VAL A  42
ASP A  43
LEU A  46
 None
 0.43A 3roxA-1jqoA:
undetectable		 3roxA-1jqoA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 ALA A 517
VAL A 520
LEU A 524
THR A 304
 None
 0.78A 3roxA-1jqoA:
undetectable		 3roxA-1jqoA:
13.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jzt HYPOTHETICAL 27.5
KDA PROTEIN IN
SPX19-GCR2
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF03853
(YjeF_N) 		6 ALA A  12
ASP A  16
LEU A  19
ASP A 173
LEU A 198
LYS A 202
 None
 0.72A 3roxA-1jztA:
34.8		 3roxA-1jztA:
39.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jzt HYPOTHETICAL 27.5
KDA PROTEIN IN
SPX19-GCR2
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF03853
(YjeF_N) 		6 ALA A  12
LEU A  19
ASP A 173
LEU A 198
THR A 199
LYS A 202
 None
 0.31A 3roxA-1jztA:
34.8		 3roxA-1jztA:
39.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5x SURVIVAL PROTEIN E

(Pyrobaculum
aerophilum) 		PF01975
(SurE) 		4 ALA A 233
VAL A 226
LEU A 227
THR A  98
 None
 0.79A 3roxA-1l5xA:
3.0		 3roxA-1l5xA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD

(Escherichia
coli) 		PF00005
(ABC_tran) 		4 ALA C 113
VAL C 110
ASP C 109
LEU C 106
 None
 0.84A 3roxA-1l7vC:
undetectable		 3roxA-1l7vC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np3 KETOL-ACID
REDUCTOISOMERASE

(Pseudomonas
aeruginosa) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 ALA A 160
VAL A 163
LEU A 103
THR A 102
 None
 0.71A 3roxA-1np3A:
5.4		 3roxA-1np3A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrk YGFZ PROTEIN

(Escherichia
coli) 		PF01571
(GCV_T) 		4 ALA A 247
VAL A 295
LEU A 280
LEU A 216
 None
 0.78A 3roxA-1nrkA:
undetectable		 3roxA-1nrkA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvj MOLYBDOPTERIN
CONVERTING FACTOR
SUBUNIT 2

(Escherichia
coli) 		PF02391
(MoaE) 		4 ALA A  64
VAL A  67
ASP A  68
THR A   4
 None
 0.75A 3roxA-1nvjA:
undetectable		 3roxA-1nvjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT

(Homo sapiens) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ALA B  30
VAL B  27
LEU B  23
LEU B 174
 None
 0.83A 3roxA-1olxB:
undetectable		 3roxA-1olxB:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT
QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
9 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF08992
(QH-AmDH_gamma)
PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		4 ASP C  49
LEU C  51
LEU A 133
THR A 132
 None
None
HEM  A 992 (-4.4A)
None
 0.75A 3roxA-1pbyC:
undetectable		 3roxA-1pbyC:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ALA A 382
VAL A 385
LEU A 389
LEU A 284
 None
 0.69A 3roxA-1pxtA:
undetectable		 3roxA-1pxtA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1) 		4 ALA A 811
VAL A 808
ASP A 807
LEU A 804
 None
 0.84A 3roxA-1qu2A:
undetectable		 3roxA-1qu2A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r55 ADAM 33

(Homo sapiens) 		PF01421
(Reprolysin) 		4 ALA A 241
VAL A 244
ASP A 245
LEU A 248
 None
 0.47A 3roxA-1r55A:
undetectable		 3roxA-1r55A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryu SWI/SNF-RELATED,
MATRIX-ASSOCIATED,
ACTIN-DEPENDENT
REGULATOR OF
CHROMATIN SUBFAMILY
F MEMBER 1

(Homo sapiens) 		PF01388
(ARID) 		4 VAL A  25
ASP A  26
LEU A  29
LEU A  12
 None
 0.80A 3roxA-1ryuA:
undetectable		 3roxA-1ryuA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8w AMP NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1)
PF10423
(AMNp_N) 		4 ALA A 176
VAL A 179
ASP A 180
LEU A 183
 None
 0.79A 3roxA-1t8wA:
undetectable		 3roxA-1t8wA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcd TRIOSEPHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00121
(TIM) 		4 ALA A 184
VAL A 187
LEU A 191
LEU A 210
 None
 0.67A 3roxA-1tcdA:
undetectable		 3roxA-1tcdA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 VAL A 899
ASP A 900
LEU A 903
LEU A 803
 None
 0.79A 3roxA-1tllA:
4.2		 3roxA-1tllA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6m ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF00583
(Acetyltransf_1) 		4 ALA A  16
VAL A  19
LEU A  23
LEU A  42
 None
 0.58A 3roxA-1u6mA:
undetectable		 3roxA-1u6mA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udx THE GTP-BINDING
PROTEIN OBG

(Thermus
thermophilus) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1)
PF09269
(DUF1967) 		4 ALA A 104
VAL A  94
LEU A 150
LEU A 114
 None
 0.79A 3roxA-1udxA:
2.3		 3roxA-1udxA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uou THYMIDINE
PHOSPHORYLASE

(Homo sapiens) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 ALA A 284
VAL A 287
LEU A 291
LEU A 371
 None
 0.60A 3roxA-1uouA:
undetectable		 3roxA-1uouA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9l GLUTAMATE
DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ALA A  87
VAL A  84
ASP A  83
LEU A  80
 None
 0.76A 3roxA-1v9lA:
6.4		 3roxA-1v9lA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ALA A 251
VAL A 254
LEU A 258
LEU A 295
 None
 0.43A 3roxA-1vc2A:
3.6		 3roxA-1vc2A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjn ZN-DEPENDENT
HYDROLASE OF
METALLO-BETA-LACTAMA
SE SUPERFAMILY
TM0207

(Thermotoga
maritima) 		PF13483
(Lactamase_B_3) 		4 ALA A 145
VAL A 148
LEU A 152
LEU A 131
 None
 0.50A 3roxA-1vjnA:
undetectable		 3roxA-1vjnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN

(Caulobacter
vibrioides) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		4 ALA A 166
VAL A 169
LEU A 173
LEU A 157
 None
 0.70A 3roxA-1w25A:
4.7		 3roxA-1w25A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS

(Escherichia
coli) 		PF01168
(Ala_racemase_N) 		4 ALA A 149
VAL A 152
LEU A 158
LEU A 126
 None
 0.84A 3roxA-1w8gA:
undetectable		 3roxA-1w8gA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ALA A 269
VAL A 272
LEU A 280
THR A 322
 ALA  A 269 ( 0.0A)
VAL  A 272 ( 0.6A)
LEU  A 280 ( 0.6A)
THR  A 322 ( 0.8A)
 0.80A 3roxA-1wqaA:
4.4		 3roxA-1wqaA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxd SHIKIMATE
5-DEHYDROGENASE

(Thermus
thermophilus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 ALA A 202
VAL A 203
ASP A 204
LEU A 205
LEU A 122
 None
 1.28A 3roxA-1wxdA:
5.8		 3roxA-1wxdA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1p ALDEHYDE REDUCTASE
II

(Sporidiobolus
salmonicolor) 		PF01370
(Epimerase) 		4 ALA A  25
VAL A  28
LEU A  32
LEU A  16
 None
 0.75A 3roxA-1y1pA:
6.0		 3roxA-1y1pA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y74 LIN 7 HOMOLOG B

(Mus musculus) 		PF02828
(L27) 		4 ALA A  26
VAL A  23
ASP A  22
LEU A  19
 None
 0.80A 3roxA-1y74A:
undetectable		 3roxA-1y74A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yox HYPOTHETICAL PROTEIN
PA3696

(Pseudomonas
aeruginosa) 		PF01987
(AIM24) 		5 ALA A 100
VAL A 101
ASP A 102
LEU A 103
LEU A   6
 None
 1.15A 3roxA-1yoxA:
undetectable		 3roxA-1yoxA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 4 ALA A 262
VAL A 265
ASP A 266
THR A 293
 None
 0.73A 3roxA-1yrgA:
undetectable		 3roxA-1yrgA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz7 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT

(Pyrococcus
abyssi) 		PF07541
(EIF_2_alpha) 		4 ALA A 121
VAL A 125
LEU A 129
LEU A 106
 None
 0.75A 3roxA-1yz7A:
undetectable		 3roxA-1yz7A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		4 ALA A 226
VAL A 229
LEU A 233
LEU A 203
 None
 0.78A 3roxA-1zzmA:
2.5		 3roxA-1zzmA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4k 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		4 ALA A  85
VAL A  11
LEU A  33
LEU A 218
 None
 0.84A 3roxA-2a4kA:
5.2		 3roxA-2a4kA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aka DYNAMIN-1

(Rattus
norvegicus) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 ALA B 190
VAL B 193
ASP B 194
LEU B 170
 None
 0.84A 3roxA-2akaB:
undetectable		 3roxA-2akaB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi0 HYPOTHETICAL PROTEIN
RV0216

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A  77
VAL A  73
ASP A  75
LEU A  72
LEU A 231
 None
 1.48A 3roxA-2bi0A:
undetectable		 3roxA-2bi0A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkj FLAVIN REDUCTASE

(Vibrio harveyi) 		PF00881
(Nitroreductase) 		5 ALA A 136
VAL A 139
ASP A 140
LEU A 143
LEU A 152
 None
 0.85A 3roxA-2bkjA:
undetectable		 3roxA-2bkjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ALA A 392
ASP A 396
LEU A 399
LEU A 373
 None
 0.53A 3roxA-2bvgA:
undetectable		 3roxA-2bvgA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF01156
(IU_nuc_hydro) 		4 ALA A  81
VAL A  84
ASP A  85
LEU A  90
 None
 0.34A 3roxA-2c40A:
4.0		 3roxA-2c40A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7z 3-KETOACYL-COA
THIOLASE 2

(Arabidopsis
thaliana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ALA A 400
VAL A 403
LEU A 407
LEU A 302
 None
 0.56A 3roxA-2c7zA:
undetectable		 3roxA-2c7zA:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dg2 APOLIPOPROTEIN A-I
BINDING PROTEIN

(Mus musculus) 		PF03853
(YjeF_N) 		4 ALA A  35
VAL A  38
ASP A  39
LEU A  42
 None
 0.82A 3roxA-2dg2A:
43.3		 3roxA-2dg2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dg2 APOLIPOPROTEIN A-I
BINDING PROTEIN

(Mus musculus) 		PF03853
(YjeF_N) 		7 ALA A  35
VAL A  38
LEU A  42
ASP A 188
LEU A 211
THR A 212
LYS A 215
 None
 0.25A 3roxA-2dg2A:
43.3		 3roxA-2dg2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Pyrococcus
horikoshii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 ALA A  83
VAL A  86
LEU A  90
LEU A 106
 None
 0.82A 3roxA-2djzA:
undetectable		 3roxA-2djzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		4 ALA A 411
VAL A 414
LEU A 418
LEU A 396
 None
 0.77A 3roxA-2dw4A:
3.3		 3roxA-2dw4A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		4 ALA B  25
VAL B 103
LEU B  45
LEU B  32
 None
 0.65A 3roxA-2fpgB:
undetectable		 3roxA-2fpgB:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR

(Mycobacterium
tuberculosis) 		PF02515
(CoA_transf_3) 		4 ALA A  24
VAL A  27
LEU A  31
LEU A 168
 None
 0.80A 3roxA-2g04A:
5.1		 3roxA-2g04A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gju 252AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		no annotation 4 ALA A 208
VAL A   6
LEU A  40
LEU A 180
 None
 0.78A 3roxA-2gjuA:
undetectable		 3roxA-2gjuA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmn METALLO-BETA-LACTAMA
SE

(Bradyrhizobium
diazoefficiens) 		PF00753
(Lactamase_B) 		5 ALA A 111
VAL A 150
LEU A 131
LEU A 104
THR A 107
 None
 1.33A 3roxA-2gmnA:
undetectable		 3roxA-2gmnA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Staphylococcus
aureus) 		PF01467
(CTP_transf_like) 		4 ALA A  22
VAL A  25
LEU A  29
LEU A   6
 None
 0.81A 3roxA-2h29A:
undetectable		 3roxA-2h29A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3g BIOSYNTHETIC PROTEIN

(Bacillus
anthracis) 		PF03309
(Pan_kinase) 		4 ALA X 219
VAL X 128
ASP X 129
LEU X 223
 None
 0.75A 3roxA-2h3gX:
undetectable		 3roxA-2h3gX:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ici EXOTOXIN I

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 VAL A  53
LEU A  51
LEU A  74
THR A  73
 None
 0.70A 3roxA-2iciA:
undetectable		 3roxA-2iciA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id0 EXORIBONUCLEASE 2

(Escherichia
coli) 		PF00575
(S1)
PF00773
(RNB)
PF08206
(OB_RNB) 		4 ALA A 229
VAL A 281
ASP A 230
LEU A 270
 None
 0.84A 3roxA-2id0A:
undetectable		 3roxA-2id0A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT
TOUB PROTEIN

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS)
PF06234
(TmoB) 		5 VAL A 451
ASP A 452
LEU A 455
LEU A 425
THR C  76
 None
 1.47A 3roxA-2incA:
undetectable		 3roxA-2incA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01842
(ACT) 		4 ALA A 436
VAL A 439
LEU A 443
LEU A 388
 None
 0.84A 3roxA-2j0wA:
undetectable		 3roxA-2j0wA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE

(Escherichia
coli) 		PF01204
(Trehalase) 		4 ALA A  54
VAL A  51
ASP A  50
LEU A  47
 None
 0.74A 3roxA-2jf4A:
undetectable		 3roxA-2jf4A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lml PUTATIVE ACYL
CARRIER PROTEIN

(Geobacter
metallireducens) 		PF00550
(PP-binding) 		4 ALA A  69
VAL A  72
ASP A  73
LEU A  76
 None
 0.41A 3roxA-2lmlA:
undetectable		 3roxA-2lmlA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mj6 PUTATIVE
TWO-COMPONENT SYSTEM
HISTIDINE KINASE

(Streptomyces
coelicolor) 		no annotation 4 ALA A  23
VAL A  26
ASP A  27
LEU A  30
 None
 0.57A 3roxA-2mj6A:
undetectable		 3roxA-2mj6A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pby GLUTAMINASE

(Geobacillus
kaustophilus) 		PF04960
(Glutaminase) 		5 ALA A 158
VAL A 157
LEU A  32
LEU A  63
THR A  62
 None
 1.31A 3roxA-2pbyA:
undetectable		 3roxA-2pbyA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg8 DPGC

(Streptomyces
toyocaensis) 		PF00378
(ECH_1) 		4 ALA A  65
VAL A  68
LEU A  72
LEU A 125
 None
 0.65A 3roxA-2pg8A:
undetectable		 3roxA-2pg8A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 107
ASP A 108
LEU A 111
ASP A  94
 None
 0.75A 3roxA-2qdeA:
undetectable		 3roxA-2qdeA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 ALA A 657
VAL A 660
LEU A 664
LEU A 693
 None
 0.75A 3roxA-2qtzA:
4.2		 3roxA-2qtzA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		4 ALA A 613
VAL A 616
LEU A 620
LEU A 635
 None
 0.81A 3roxA-2qvwA:
undetectable		 3roxA-2qvwA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6i UNCHARACTERIZED
PROTEIN ATU1473

(Agrobacterium
fabrum) 		PF07542
(ATP12) 		4 ALA A 253
VAL A 256
LEU A 260
LEU A 189
 None
 0.64A 3roxA-2r6iA:
undetectable		 3roxA-2r6iA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		4 ALA A 190
VAL A 193
LEU A 197
LEU A  59
 None
 0.77A 3roxA-2r98A:
undetectable		 3roxA-2r98A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjb UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		PF07063
(DUF1338) 		4 ALA A  42
VAL A  39
ASP A  38
LEU A  35
 None
 0.80A 3roxA-2rjbA:
undetectable		 3roxA-2rjbA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		4 ALA A 424
VAL A 427
LEU A 431
LEU A 345
 None
 0.83A 3roxA-2v26A:
undetectable		 3roxA-2v26A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 VAL A 389
ASP A 390
LEU A 393
LEU A 421
 None
 0.78A 3roxA-2vosA:
undetectable		 3roxA-2vosA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w48 SORBITOL OPERON
REGULATOR

(Klebsiella
pneumoniae) 		PF04198
(Sugar-bind)
PF13936
(HTH_38) 		4 ALA A 100
VAL A 103
ASP A 104
LEU A 107
 None
 0.31A 3roxA-2w48A:
4.3		 3roxA-2w48A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 VAL A 255
LEU A 259
LEU A 308
THR A 307
 None
 0.79A 3roxA-2xf8A:
3.3		 3roxA-2xf8A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 ALA A 441
VAL A 438
ASP A 437
LEU A 434
 EDO  A1750 ( 4.6A)
None
None
None
 0.74A 3roxA-2xijA:
4.9		 3roxA-2xijA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9

(Schizosaccharomyces
pombe) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 ALA A 226
VAL A 229
ASP A 230
LEU A 198
 None
 0.73A 3roxA-2xpiA:
undetectable		 3roxA-2xpiA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ALA A  76
VAL A  79
LEU A  83
LEU A 611
 None
 0.80A 3roxA-2y8nA:
undetectable		 3roxA-2y8nA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfh GLUTAMATE
DEHYDROGENASE,
NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE,
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli;
[Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ALA A 394
VAL A 397
ASP A 398
LEU A 401
 None
 0.69A 3roxA-2yfhA:
6.1		 3roxA-2yfhA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS

(Mycobacterium
tuberculosis) 		PF12282
(H_kinase_N) 		4 ALA A 229
VAL A 232
ASP A 233
THR A 219
 None
 0.68A 3roxA-2ykfA:
undetectable		 3roxA-2ykfA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8t ADENYLATE
ISOPENTENYLTRANSFERA
SE

(Humulus lupulus) 		PF01715
(IPPT) 		4 ALA A 182
VAL A 185
ASP A 186
LEU A 189
 None
 0.81A 3roxA-3a8tA:
undetectable		 3roxA-3a8tA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akc CYTIDYLATE KINASE

(Thermus
thermophilus) 		PF02224
(Cytidylate_kin) 		4 ALA A 101
VAL A 100
LEU A  57
LEU A  36
 CDP  A 209 (-3.6A)
None
None
None
 0.78A 3roxA-3akcA:
undetectable		 3roxA-3akcA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apm PROTEIN-ARGININE
DEIMINASE TYPE-4

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		4 ALA A 204
VAL A 203
LEU A 267
LEU A 264
 None
 0.72A 3roxA-3apmA:
undetectable		 3roxA-3apmA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buj CALO2

(Micromonospora
echinospora) 		PF00067
(p450) 		4 ALA A 111
VAL A 114
ASP A 115
LEU A 118
 None
 0.66A 3roxA-3bujA:
undetectable		 3roxA-3bujA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxo N,N-DIMETHYLTRANSFER
ASE

(Streptomyces
venezuelae) 		PF13649
(Methyltransf_25) 		5 ALA A  46
VAL A  45
ASP A  44
LEU A  43
LEU A  85
 SAM  A 238 (-3.2A)
None
None
None
None
 1.42A 3roxA-3bxoA:
5.3		 3roxA-3bxoA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8t FUMARATE LYASE

(Chelativorans
sp. BNC1) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 ALA A 379
VAL A 382
LEU A 386
LEU A 401
 None
 0.74A 3roxA-3c8tA:
undetectable		 3roxA-3c8tA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvh 25-D1.16 LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA L  83
VAL L  82
ASP L  81
LEU L  77
LEU L  72
 None
 1.47A 3roxA-3cvhL:
undetectable		 3roxA-3cvhL:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3df7 PUTATIVE ATP-GRASP
SUPERFAMILY PROTEIN

(Archaeoglobus
fulgidus) 		PF02655
(ATP-grasp_3) 		4 ALA A 198
VAL A 281
LEU A 299
THR A 251
 None
 0.83A 3roxA-3df7A:
3.3		 3roxA-3df7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dip ENOLASE

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A  86
VAL A  89
ASP A  90
LEU A  93
 None
 0.32A 3roxA-3dipA:
undetectable		 3roxA-3dipA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		4 ALA A 374
VAL A 373
LEU A 350
LEU A 432
 None
 0.81A 3roxA-3e1sA:
undetectable		 3roxA-3e1sA:
19.13