SIMILAR PATTERNS OF AMINO ACIDS FOR 3ROD_A_NCAA302_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0i D-AMINO ACID OXIDASE

(Rhodotorula
toruloides) 		PF01266
(DAO) 		4 TYR A1108
LEU A1103
ALA A1097
SER A1215
 None
 1.02A 3rodA-1c0iA:
undetectable		 3rodA-1c0iA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		4 LEU A 100
ALA A  96
SER A  90
TYR A  88
 None
 0.94A 3rodA-1dr6A:
2.7		 3rodA-1dr6A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ASP A 610
ALA A 609
SER A 574
SER A 586
 None
 1.00A 3rodA-1f4hA:
undetectable		 3rodA-1f4hA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II

(Streptomyces
exfoliatus) 		PF13540
(RCC1_2) 		4 LEU B 194
ASP B 187
ALA B 226
SER B 266
 None
CA  B 502 (-2.3A)
None
None
 1.09A 3rodA-1jtdB:
undetectable		 3rodA-1jtdB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		4 TYR A  55
ALA A 179
SER A 176
SER A 145
 None
SO4  A 322 ( 4.3A)
SO4  A 322 ( 3.9A)
SO4  A 322 (-2.9A)
 1.00A 3rodA-1k8gA:
undetectable		 3rodA-1k8gA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		5 TYR A 581
ALA A  35
SER A 322
TYR A 337
SER A 320
 ACR  A 700 (-3.7A)
None
None
ACR  A 700 (-4.3A)
None
 1.31A 3rodA-1lf9A:
undetectable		 3rodA-1lf9A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
CYTOLETHAL
DISTENDING TOXIN
PROTEIN C

([Haemophilus]
ducreyi;
[Haemophilus]
ducreyi) 		PF03498
(CDtoxinA)
PF03498
(CDtoxinA) 		4 TYR A 182
SER A 166
SER C 173
TYR A 211
 None
 1.01A 3rodA-1sr4A:
undetectable		 3rodA-1sr4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor) 		PF00232
(Glyco_hydro_1) 		4 LEU A  30
ASP A  94
ALA A  95
TYR A 138
 None
 1.08A 3rodA-1v02A:
undetectable		 3rodA-1v02A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		4 ASP A 109
ALA A 105
SER A 205
SER A 201
 None
 0.99A 3rodA-1vgmA:
undetectable		 3rodA-1vgmA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		4 TYR A 396
ASP A 388
TYR A 384
SER A 526
 IMD  A 821 (-3.5A)
None
TPQ  A 478 ( 4.7A)
None
 0.98A 3rodA-1w7cA:
undetectable		 3rodA-1w7cA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		4 TYR A 396
SER A 386
TYR A 384
SER A 526
 IMD  A 821 (-3.5A)
None
TPQ  A 478 ( 4.7A)
None
 1.07A 3rodA-1w7cA:
undetectable		 3rodA-1w7cA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		4 LEU A  44
ASP A  42
SER A  51
TYR A 371
 None
NAD  A 703 (-2.7A)
None
None
 1.08A 3rodA-1z45A:
5.8		 3rodA-1z45A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM

(Bacillus
subtilis) 		PF00724
(Oxidored_FMN) 		4 ALA A 252
SER A 217
SER A 249
TYR A 169
 None
None
FMN  A1500 ( 4.4A)
None
 1.03A 3rodA-1z48A:
undetectable		 3rodA-1z48A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlp PETAL DEATH PROTEIN

(Dianthus
caryophyllus) 		PF13714
(PEP_mutase) 		4 ASP A  79
SER A  69
SER A  66
TYR A 262
 MG  A 401 (-3.8A)
None
None
None
 0.87A 3rodA-1zlpA:
undetectable		 3rodA-1zlpA:
21.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		4 TYR A  20
LEU A 164
TYR A 204
TYR A 242
 SAH  A4001 (-4.2A)
SAH  A4001 (-4.3A)
None
None
 0.43A 3rodA-2a14A:
43.2		 3rodA-2a14A:
48.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		4 LEU A  95
ALA A  99
TYR A 185
TYR A 111
 None
 1.09A 3rodA-2amgA:
undetectable		 3rodA-2amgA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		5 TYR A 103
LEU A  94
ALA A 382
SER A 222
SER A 227
 None
 1.38A 3rodA-2csdA:
undetectable		 3rodA-2csdA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF01497
(Peripla_BP_2) 		4 ASP A 298
ALA A 297
TYR A 333
TYR A 324
 None
 1.06A 3rodA-2etvA:
undetectable		 3rodA-2etvA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grk EVM001

(Ectromelia
virus) 		PF02250
(Orthopox_35kD) 		4 ASP A  25
SER A  91
SER A  93
TYR A 112
 None
 1.03A 3rodA-2grkA:
undetectable		 3rodA-2grkA:
19.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		8 TYR A  21
LEU A 165
ASP A 198
ALA A 199
SER A 202
TYR A 205
SER A 214
TYR A 243
 SAH  A4001 (-4.5A)
SAH  A4001 (-4.2A)
None
None
None
None
None
None
 0.28A 3rodA-2i62A:
45.3		 3rodA-2i62A:
79.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		6 TYR A  26
LEU A 165
ASP A 198
ALA A 199
SER A 202
TYR A 243
 SAH  A4001 (-4.4A)
SAH  A4001 (-4.2A)
None
None
None
None
 1.40A 3rodA-2i62A:
45.3		 3rodA-2i62A:
79.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ic7 MALTOSE
TRANSACETYLASE

(Geobacillus
kaustophilus) 		PF00132
(Hexapep)
PF12464
(Mac)
PF14602
(Hexapep_2) 		4 TYR A  73
LEU A  21
ASP A  18
SER A   3
 None
 1.01A 3rodA-2ic7A:
undetectable		 3rodA-2ic7A:
23.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2iip NICOTINAMIDE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		8 TYR A  20
LEU A 164
ASP A 197
ALA A 198
SER A 201
TYR A 204
SER A 213
TYR A 242
 SAH  A4001 (-4.6A)
SAH  A4001 (-4.1A)
None
None
None
None
None
None
 0.37A 3rodA-2iipA:
44.3		 3rodA-2iipA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2iip NICOTINAMIDE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		4 TYR A  20
LEU A 164
ASP A 197
SER A 201
 SAH  A4001 (-4.6A)
SAH  A4001 (-4.1A)
None
None
 0.94A 3rodA-2iipA:
44.3		 3rodA-2iipA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2iip NICOTINAMIDE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		6 TYR A  25
LEU A 164
ASP A 197
ALA A 198
SER A 201
TYR A 242
 SAH  A4001 (-4.4A)
SAH  A4001 (-4.1A)
None
None
None
None
 1.35A 3rodA-2iipA:
44.3		 3rodA-2iipA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc2 INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF13517
(VCBS) 		4 LEU A 421
ALA A 377
SER A 358
SER A 292
 None
 1.11A 3rodA-2vc2A:
undetectable		 3rodA-2vc2A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpt LIPOLYTIC ENZYME

(Ruminiclostridium
thermocellum) 		PF13472
(Lipase_GDSL_2) 		4 LEU A 191
ASP A 157
ALA A 156
TYR A 224
 None
 1.10A 3rodA-2vptA:
3.1		 3rodA-2vptA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al9 PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 LEU A 424
ALA A 460
SER A 444
SER A 437
 None
 0.99A 3rodA-3al9A:
undetectable		 3rodA-3al9A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 ASP A 396
ALA A 395
SER A 192
TYR A 189
 None
 0.95A 3rodA-3aupA:
undetectable		 3rodA-3aupA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11

(Methanocaldococcus
jannaschii) 		PF00149
(Metallophos) 		4 ASP A   8
ALA A   7
SER A  47
TYR A 202
 MN  A 401 (-3.3A)
None
None
None
 1.10A 3rodA-3auzA:
undetectable		 3rodA-3auzA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		5 LEU A 444
ALA A 447
SER A 451
SER A  12
TYR A 388
 None
 1.35A 3rodA-3azqA:
undetectable		 3rodA-3azqA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 338
ALA A 339
TYR A 150
TYR A 171
 None
 1.10A 3rodA-3ddmA:
undetectable		 3rodA-3ddmA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ein GLUTATHIONE
S-TRANSFERASE 1-1

(Drosophila
melanogaster) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A  98
ASP A 101
ALA A 159
SER A  15
SER A  66
 None
None
None
None
GSH  A 210 (-2.6A)
 1.38A 3rodA-3einA:
undetectable		 3rodA-3einA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6f CG18548-PA
(IP02196P)
(IP02193P)

(Drosophila
melanogaster) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 LEU A  98
ASP A 101
ALA A 159
SER A  14
SER A  66
 None
 1.40A 3rodA-3f6fA:
undetectable		 3rodA-3f6fA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Yersinia pestis) 		PF00425
(Chorismate_bind) 		4 TYR A 261
LEU A 393
ALA A  79
SER A 123
 None
 1.11A 3rodA-3gseA:
undetectable		 3rodA-3gseA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihm STYRENE
MONOOXYGENASE A

(Pseudomonas
putida) 		no annotation 4 LEU A  44
ASP A 267
SER A 207
SER A 202
 None
 1.01A 3rodA-3ihmA:
undetectable		 3rodA-3ihmA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izk CHAPERONIN

(Methanococcus
maripaludis) 		PF00118
(Cpn60_TCP1) 		4 ASP A 454
ALA A 443
SER A 378
SER A 374
 None
 0.91A 3rodA-3izkA:
undetectable		 3rodA-3izkA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH

(Streptomyces
glaucescens) 		PF13416
(SBP_bac_8) 		4 TYR A 187
LEU A 158
ALA A 162
SER A 223
 None
 1.05A 3rodA-3jzjA:
undetectable		 3rodA-3jzjA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 325
ALA A  29
SER A  31
SER A  11
 None
 1.02A 3rodA-3kumA:
undetectable		 3rodA-3kumA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
SUMO-ACTIVATING
ENZYME SUBUNIT 2

(Homo sapiens;
Homo sapiens) 		PF00899
(ThiF)
PF00899
(ThiF)
PF14732
(UAE_UbL) 		4 LEU B   7
SER A 297
SER A 259
TYR A 161
 None
 1.06A 3rodA-3kydB:
4.1		 3rodA-3kydB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Jannaschia sp.
CCS1) 		PF07848
(PaaX) 		4 LEU A 143
ALA A 224
SER A 221
SER A 133
 None
 0.93A 3rodA-3l09A:
undetectable		 3rodA-3l09A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfu DNA HELICASE II

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 LEU A 308
ALA A  31
SER A 285
TYR A 600
 None
SO4  A1000 (-3.3A)
None
None
 0.96A 3rodA-3lfuA:
3.0		 3rodA-3lfuA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkb PROBABLE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER, AMINO
ACID BINDING PROTEIN

(Thermus
thermophilus) 		PF13458
(Peripla_BP_6) 		4 TYR A  82
ASP A 237
ALA A 208
TYR A 232
 VAL  A 393 (-3.9A)
None
None
VAL  A 393 (-4.0A)
 1.06A 3rodA-3lkbA:
undetectable		 3rodA-3lkbA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3md2 MATRIX PROTEIN 1

(Influenza A
virus) 		PF00598
(Flu_M1) 		4 ASP A 156
ALA A 155
SER A  13
TYR A  10
 None
 0.97A 3rodA-3md2A:
undetectable		 3rodA-3md2A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2q SEX PHEROMONE
STAPH-CAM373

(Bacillus cereus) 		PF07537
(CamS) 		4 TYR A 130
LEU A  84
ALA A 188
SER A 206
 None
 1.01A 3rodA-3n2qA:
undetectable		 3rodA-3n2qA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4f SPERMIDINE SYNTHASE

(Escherichia
coli) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 TYR A 226
ASP A  88
ALA A  90
TYR A  63
 None
 1.11A 3rodA-3o4fA:
10.5		 3rodA-3o4fA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 ASP B 950
ALA B 949
SER B 773
SER B 781
 None
 0.95A 3rodA-3o8oB:
undetectable		 3rodA-3o8oB:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 LEU A 424
ALA A 460
SER A 444
SER A 437
 None
 0.90A 3rodA-3okyA:
undetectable		 3rodA-3okyA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyy RESPONSE REGULATOR

(Xanthomonas
campestris) 		PF00990
(GGDEF) 		4 TYR A 201
LEU A 144
ALA A 152
SER A 156
 None
 0.94A 3rodA-3qyyA:
undetectable		 3rodA-3qyyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]

(Saccharomyces
cerevisiae) 		PF05222
(AlaDh_PNT_N) 		4 LEU A   8
ALA A  19
SER A  44
SER A  41
 None
 1.03A 3rodA-3ugkA:
undetectable		 3rodA-3ugkA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8x TRANSFERRIN-BINDING
PROTEIN 1

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 TYR A 583
ALA A 172
SER A 170
SER A 110
 None
 1.11A 3rodA-3v8xA:
undetectable		 3rodA-3v8xA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		4 LEU A 536
ALA A 532
SER A 525
TYR A 606
 None
 1.06A 3rodA-3v94A:
undetectable		 3rodA-3v94A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 TYR A 493
ASP A 344
ALA A 677
SER A 631
 None
GLC  A 801 (-2.4A)
None
SO4  A 803 (-3.5A)
 1.08A 3rodA-3wiqA:
undetectable		 3rodA-3wiqA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj2 CARBOXYLESTERASE

(Ferroplasma
acidiphilum) 		PF07859
(Abhydrolase_3) 		4 LEU A 161
ALA A 157
SER A 186
TYR A 217
 None
 1.12A 3rodA-3wj2A:
undetectable		 3rodA-3wj2A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2g GH3-1 AUXIN
CONJUGATING ENZYME

(Vitis vinifera) 		PF03321
(GH3) 		4 TYR A 342
LEU A 173
SER A 444
SER A 108
 V1N  A1600 (-4.4A)
MLI  A1599 (-3.9A)
MLI  A1599 (-3.3A)
V1N  A1600 ( 2.5A)
 1.10A 3rodA-4b2gA:
undetectable		 3rodA-4b2gA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c16 E-SELECTIN

(Homo sapiens) 		PF00008
(EGF)
PF00059
(Lectin_C)
PF00084
(Sushi) 		4 ALA A   9
SER A  47
TYR A  49
SER A  45
 None
 0.98A 3rodA-4c16A:
undetectable		 3rodA-4c16A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 LEU A 315
ALA A  34
SER A 292
TYR A 612
 None
ANP  A1662 (-3.8A)
None
None
 1.10A 3rodA-4c30A:
undetectable		 3rodA-4c30A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2

(Streptococcus
pneumoniae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 TYR A 791
ALA A 649
SER A 647
SER A 692
 None
 1.00A 3rodA-4cu8A:
undetectable		 3rodA-4cu8A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eca L-ASPARAGINE
AMIDOHYDROLASE

(Escherichia
coli) 		PF00710
(Asparaginase) 		4 ASP A 124
ALA A 123
SER A 120
TYR A  25
 None
None
None
AEI  A  12 (-4.0A)
 1.10A 3rodA-4ecaA:
undetectable		 3rodA-4ecaA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9l 20.1 ANTI-BTN3A1
ANTIBODY FRAGMENT

(Mus musculus) 		no annotation 4 ASP D 231
ALA D 239
SER D  34
TYR D  96
 None
 0.97A 3rodA-4f9lD:
undetectable		 3rodA-4f9lD:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzl BACTERIOCIN

(Pseudomonas
syringae group
genomosp. 3) 		PF14859
(Colicin_M) 		4 TYR A 261
ASP A  87
ALA A  84
TYR A 120
 None
 1.08A 3rodA-4fzlA:
undetectable		 3rodA-4fzlA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Bacillus
anthracis) 		PF00144
(Beta-lactamase) 		4 TYR A 191
LEU A 208
ALA A 298
SER A 137
 None
None
None
NO3  A 601 (-3.2A)
 1.10A 3rodA-4gb7A:
undetectable		 3rodA-4gb7A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF04857
(CAF1) 		4 TYR B 164
LEU B  72
ALA B 109
SER B 112
 None
 1.08A 3rodA-4gmjB:
undetectable		 3rodA-4gmjB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4goj PROTEIN UNC-119
HOMOLOG A

(Homo sapiens) 		PF05351
(GMP_PDE_delta) 		4 ALA C 232
SER C 216
SER C 218
TYR C 131
 None
 1.11A 3rodA-4gojC:
undetectable		 3rodA-4gojC:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A  97
ALA A 224
SER A 222
SER A 101
 None
 1.05A 3rodA-4h7uA:
undetectable		 3rodA-4h7uA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 LEU M 115
ALA M 166
SER M 170
SER M 172
 None
 1.04A 3rodA-4heaM:
undetectable		 3rodA-4heaM:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6v AMIDOHYDROLASE 2

(Planctopirus
limnophila) 		PF02614
(UxaC) 		4 LEU A 378
SER A  26
SER A 373
TYR A 158
 None
 0.90A 3rodA-4i6vA:
undetectable		 3rodA-4i6vA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE

(Scaptomyza
nigrita) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A  98
ASP A 101
ALA A 159
SER A  15
SER A  66
 None
None
None
None
GSH  A 301 (-2.7A)
 1.37A 3rodA-4i97A:
undetectable		 3rodA-4i97A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		4 LEU A 312
ALA A  58
SER A  56
SER A  86
 None
PO4  A 401 (-3.2A)
PO4  A 401 (-3.8A)
PO4  A 401 (-2.7A)
 1.06A 3rodA-4lvqA:
undetectable		 3rodA-4lvqA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdk UBIQUITIN-CONJUGATIN
G ENZYME E2 R1

(Homo sapiens) 		PF00179
(UQ_con) 		4 ALA A  12
SER A   8
TYR A  70
TYR A  68
 None
 1.12A 3rodA-4mdkA:
undetectable		 3rodA-4mdkA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 TYR A 431
LEU A 412
SER A 405
TYR A 403
 None
 0.98A 3rodA-4mivA:
undetectable		 3rodA-4mivA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfitobacterium
hafniense) 		PF13458
(Peripla_BP_6) 		4 TYR A 282
ASP A  52
ALA A  54
SER A  18
 None
 1.11A 3rodA-4mlcA:
undetectable		 3rodA-4mlcA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Megavirus
chiliensis) 		no annotation 4 TYR B 344
ASP B 382
ALA B 379
TYR B 391
 None
 0.87A 3rodA-4p37B:
undetectable		 3rodA-4p37B:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00266
(Aminotran_5) 		4 LEU A 161
ALA A 136
SER A 189
SER A 194
 None
 0.89A 3rodA-4q76A:
undetectable		 3rodA-4q76A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU A 106
ALA A 104
SER A  90
TYR A  59
 None
 1.09A 3rodA-4r0iA:
undetectable		 3rodA-4r0iA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4g PUTATIVE LIPOPROTEIN
YCDA

(Bacillus
subtilis) 		PF11611
(DUF4352)
PF17118
(DUF5105) 		4 LEU A  83
ALA A  43
SER A  40
TYR A 140
 None
 0.92A 3rodA-4r4gA:
undetectable		 3rodA-4r4gA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v03 SITE-DETERMINING
PROTEIN

(Aquifex
aeolicus) 		PF01656
(CbiA) 		4 LEU A 196
ASP A 155
ALA A 154
TYR A 169
 None
 1.11A 3rodA-4v03A:
undetectable		 3rodA-4v03A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 4 TYR A 344
ASP A 394
ALA A 391
TYR A 403
 None
 1.07A 3rodA-4wseA:
undetectable		 3rodA-4wseA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxp NS3-4 PROTEASE

(Hepacivirus C) 		PF07652
(Flavi_DEAD) 		4 TYR A 218
LEU A 202
ALA A 204
SER A 208
 None
 1.11A 3rodA-4wxpA:
2.1		 3rodA-4wxpA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgh CITRATE SYNTHASE

(Burkholderia
thailandensis) 		PF00285
(Citrate_synt) 		4 LEU A 230
ALA A  82
TYR A  73
SER A  90
 None
 0.97A 3rodA-4xghA:
undetectable		 3rodA-4xghA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwl EXOGLUCANASE S

(Clostridium
cellulovorans) 		PF02011
(Glyco_hydro_48) 		4 LEU A 626
SER A 493
TYR A 623
SER A 522
 None
 1.05A 3rodA-4xwlA:
undetectable		 3rodA-4xwlA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cgz 4-OXALMESACONATE
HYDRATASE

(Pseudomonas
putida) 		PF02585
(PIG-L) 		4 ASP A  17
ALA A  13
SER A  42
TYR A  90
 ZN  A 301 (-2.2A)
ZN  A 301 ( 4.7A)
None
None
 0.97A 3rodA-5cgzA:
3.0		 3rodA-5cgzA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqe MATRIX PROTEIN 1

(Influenza A
virus) 		PF00598
(Flu_M1) 		4 ASP A 156
ALA A 155
SER A  13
TYR A  10
 None
 0.92A 3rodA-5cqeA:
undetectable		 3rodA-5cqeA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11

(Methanocaldococcus
jannaschii) 		PF00149
(Metallophos) 		4 ASP A   8
ALA A   7
SER A  47
TYR A 202
 MG  A 401 (-2.8A)
None
None
None
 1.04A 3rodA-5dnyA:
undetectable		 3rodA-5dnyA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esy SAL1 PHOSPHATASE

(Arabidopsis
thaliana) 		PF00459
(Inositol_P) 		4 TYR A 274
ASP A 137
ALA A 149
TYR A 263
 None
 0.85A 3rodA-5esyA:
undetectable		 3rodA-5esyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT SKI6
EXOSOME COMPLEX
COMPONENT RRP4

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF14382
(ECR1_N)
PF15985
(KH_6) 		4 TYR B 157
LEU B 232
ALA B 236
SER H  52
 None
 0.90A 3rodA-5g06B:
undetectable		 3rodA-5g06B:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT
FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		PF01798
(Nop)
PF01269
(Fibrillarin) 		4 TYR E 105
LEU A  97
ALA A 101
TYR A 114
 None
 0.84A 3rodA-5ginE:
12.7		 3rodA-5ginE:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 LEU B1132
ASP B1173
ALA B1222
SER B1248
 None
 1.09A 3rodA-5gztB:
undetectable		 3rodA-5gztB:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 LEU A1132
ASP A1173
ALA A1222
SER A1248
 None
 1.09A 3rodA-5gzuA:
undetectable		 3rodA-5gzuA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdf HYDROLASE

(Streptomyces
flocculus) 		no annotation 4 TYR B 108
LEU B 351
ALA B 303
SER B 364
 None
 0.95A 3rodA-5hdfB:
undetectable		 3rodA-5hdfB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		5 TYR A 103
LEU A  94
ALA A 382
SER A 222
SER A 227
 None
 1.45A 3rodA-5hm5A:
undetectable		 3rodA-5hm5A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 LEU A 424
ALA A 460
SER A 444
SER A 437
 None
 0.89A 3rodA-5l5gA:
undetectable		 3rodA-5l5gA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7k PROTEIN UNC-119
HOMOLOG A

(Homo sapiens) 		PF05351
(GMP_PDE_delta) 		4 ALA A 232
SER A 216
SER A 218
TYR A 131
 None
 1.11A 3rodA-5l7kA:
undetectable		 3rodA-5l7kA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkf POLYCYSTIN-2

(Homo sapiens) 		PF08016
(PKD_channel) 		4 LEU A 288
ALA A 403
TYR A 292
SER A 396
 None
 1.10A 3rodA-5mkfA:
undetectable		 3rodA-5mkfA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 4 LEU A 623
ASP A 254
ALA A 251
SER A 628
 None
 1.11A 3rodA-5nd1A:
undetectable		 3rodA-5nd1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 4 TYR A 218
LEU A 202
ALA A 204
SER A 208
 None
 1.04A 3rodA-5wdxA:
undetectable		 3rodA-5wdxA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8g 2-SUCCINYLBENZOATE--
COA LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A  83
ALA A  57
SER A 101
SER A  99
 None
 1.09A 3rodA-5x8gA:
undetectable		 3rodA-5x8gA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyb -

(-) 		no annotation 4 TYR A 159
ALA A 220
SER A 217
SER A 201
 None
 1.11A 3rodA-5xybA:
undetectable		 3rodA-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zwp GLUTATHIONE
S-TRANSFERASE 1

(Musca domestica) 		no annotation 5 LEU A  97
ASP A 100
ALA A 158
SER A  14
SER A  65
 None
None
None
None
GSH  A 301 (-2.6A)
 1.39A 3rodA-5zwpA:
undetectable		 3rodA-5zwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egt GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		no annotation 4 LEU A 890
ASP A 893
ALA A1009
SER A 752
 None
 1.11A 3rodA-6egtA:
undetectable		 3rodA-6egtA:
19.40