SIMILAR PATTERNS OF AMINO ACIDS FOR 3RNJ_A_EDTA1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1khc	DNA CYTOSINE-5 METHYLTRANSFERASE 3B2 (Mus musculus)	PF00855 (PWWP)	4	LYS A 315 ARG A 319 LEU A 235 ASP A 234	UNX A 177 (-2.8A) UNX A 172 (-4.2A) None None	1.25A	3rnjA-1khcA: 2.5	3rnjA-1khcA: 18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2zu6	EUKARYOTIC INITIATION FACTOR 4A-I (Homo sapiens)	PF00270 (DEAD) PF00271 (Helicase_C)	4	LYS A 291 ARG A 295 LEU A 260 ASP A 261	None	1.25A	3rnjA-2zu6A: 0.0	3rnjA-2zu6A: 9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3bln	ACETYLTRANSFERASE GNAT FAMILY (Bacillus cereus)	PF00583 (Acetyltransf_1)	4	LYS A 33 ARG A 29 LEU A 12 ASP A 13	None	1.26A	3rnjA-3blnA: 0.0	3rnjA-3blnA: 19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3rnj	BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2 (Homo sapiens)	PF14604 (SH3_9)	4	LYS A 380 ARG A 433 LEU A 435 ASP A 436	EDT A 1 (-2.7A) EDT A 1 (-2.7A) EDT A 1 (-4.3A) EDT A 1 (-3.8A)	0.00A	3rnjA-3rnjA: 16.8	3rnjA-3rnjA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3v2i	PEPTIDYL-TRNA HYDROLASE (Burkholderia thailandensis)	PF01195 (Pept_tRNA_hydro)	4	LYS A 103 ARG A 132 LEU A 97 ASP A 96	None	1.36A	3rnjA-3v2iA: undetectable	3rnjA-3v2iA: 17.22

[["3RNJ_A_EDTA1_0","1khc","Mus musculus","DNA CYTOSINE-5 METHYLTRANSFERASE 3B2","PF00855(PWWP)",4,"LYS A 315;ARG A 319;LEU A 235;ASP A 234","UNX A 177 (-2.8A);UNX A 172 (-4.2A);None;None","1.25A","3rnjA-1khcA:2.5","3rnjA-1khcA:18.37"],["3RNJ_A_EDTA1_0","2zu6","Homo sapiens","EUKARYOTIC INITIATION FACTOR 4A-I","PF00270(DEAD);PF00271(Helicase_C)",4,"LYS A 291;ARG A 295;LEU A 260;ASP A 261","None","1.25A","3rnjA-2zu6A:0.0","3rnjA-2zu6A:9.90"],["3RNJ_A_EDTA1_0","3bln","Bacillus cereus","ACETYLTRANSFERASE GNAT FAMILY","PF00583(Acetyltransf_1)",4,"LYS A  33;ARG A  29;LEU A  12;ASP A  13","None","1.26A","3rnjA-3blnA:0.0","3rnjA-3blnA:19.72"],["3RNJ_A_EDTA1_0","3rnj","Homo sapiens","BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2","PF14604(SH3_9)",4,"LYS A 380;ARG A 433;LEU A 435;ASP A 436","EDT A   1 (-2.7A);EDT A   1 (-2.7A);EDT A   1 (-4.3A);EDT A   1 (-3.8A)","0.00A","3rnjA-3rnjA:16.8","3rnjA-3rnjA:100.00"],["3RNJ_A_EDTA1_0","3v2i","Burkholderia thailandensis","PEPTIDYL-TRNA HYDROLASE","PF01195(Pept_tRNA_hydro)",4,"LYS A 103;ARG A 132;LEU A  97;ASP A  96","None","1.36A","3rnjA-3v2iA:undetectable","3rnjA-3v2iA:17.22"]]