SIMILAR PATTERNS OF AMINO ACIDS FOR 3RHG_A_BEZA369

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP2)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP3)

(Rhinovirus A;
Rhinovirus A;
Rhinovirus A) 		PF00073
(Rhv)
PF00073
(Rhv)
PF00073
(Rhv) 		5 LEU 2 184
PHE 2 190
GLU 1  38
ASP 3  50
PHE 3 212
 None
 1.04A 3rhgA-1r1a2:
0.0		 3rhgA-1r1a2:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euh CHROMOSOME PARTITION
PROTEIN MUKF
MUKE

(Escherichia
coli;
Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M)
PF17193
(MukF_C)
PF04288
(MukE) 		5 LEU C 113
PHE C 194
GLU C  79
ASP A 292
PHE A 297
 None
 1.43A 3rhgA-3euhC:
0.0		 3rhgA-3euhC:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN

(Rhodobacter
sphaeroides) 		PF02126
(PTE) 		6 HIS A 207
TRP A 211
HIS A 236
MET A 261
ASP A 302
PHE A 304
 ZN  A 401 (-3.4A)
None
ZN  A 401 (-3.5A)
None
ZN  A 400 (-2.6A)
DTV  A 402 (-4.2A)
 0.17A 3rhgA-3k2gA:
51.5		 3rhgA-3k2gA:
39.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rhg PUTATIVE
PHOPHOTRIESTERASE

(Proteus
mirabilis) 		PF02126
(PTE) 		8 HIS A 199
HIS A 229
MET A 254
LEU A 257
PHE A 261
GLU A 264
ASP A 294
PHE A 296
 ZN  A 368 (-3.1A)
ZN  A 368 (-3.2A)
BEZ  A 369 ( 3.9A)
None
BEZ  A 369 (-4.3A)
BEZ  A 369 ( 4.4A)
CAC  A 370 (-2.4A)
CAC  A 370 (-3.5A)
 0.58A 3rhgA-3rhgA:
70.6		 3rhgA-3rhgA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rhg PUTATIVE
PHOPHOTRIESTERASE

(Proteus
mirabilis) 		PF02126
(PTE) 		9 TYR A  63
HIS A 199
TRP A 203
HIS A 229
MET A 254
LEU A 257
PHE A 261
ASP A 294
PHE A 296
 UNL  A 373 ( 3.6A)
ZN  A 368 (-3.1A)
None
ZN  A 368 (-3.2A)
BEZ  A 369 ( 3.9A)
None
BEZ  A 369 (-4.3A)
CAC  A 370 (-2.4A)
CAC  A 370 (-3.5A)
 0.01A 3rhgA-3rhgA:
70.6		 3rhgA-3rhgA:
100.00