SIMILAR PATTERNS OF AMINO ACIDS FOR 3RGL_A_GLYA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6j NITROGEN REGULATORY
IIA PROTEIN

(Escherichia
coli) 		PF00359
(PTS_EIIA_2) 		4 ALA A  70
GLY A  64
THR A  63
GLU A  58
 None
 0.89A 3rglA-1a6jA:
0.2		 3rglA-1a6jA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e12 HALORHODOPSIN

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		4 ALA A 190
GLY A 191
THR A 192
THR A 259
 None
 0.96A 3rglA-1e12A:
undetectable		 3rglA-1e12A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE

(Moorella
thermoacetica) 		PF01268
(FTHFS) 		4 ALA A1070
GLY A1071
THR A1068
THR A1333
 None
 0.93A 3rglA-1eg7A:
undetectable		 3rglA-1eg7A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq8 PECTINESTERASE

(Daucus carota) 		PF01095
(Pectinesterase) 		4 ALA A 164
GLY A 198
THR A 197
GLN A 188
 None
 0.92A 3rglA-1gq8A:
undetectable		 3rglA-1gq8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4v HISTIDYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 GLY B  82
THR B  83
GLN B 126
GLU B 130
 None
 0.82A 3rglA-1h4vB:
10.5		 3rglA-1h4vB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		4 ALA A 836
GLY A 833
THR A 832
GLN A 852
 None
 0.92A 3rglA-1h7wA:
undetectable		 3rglA-1h7wA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htt HISTIDYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 GLY A  84
THR A  85
GLN A 127
GLU A 131
 None
HIS  A 450 ( 3.2A)
HIS  A 450 (-3.1A)
HIS  A 450 ( 3.0A)
 0.67A 3rglA-1httA:
10.6		 3rglA-1httA:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermotoga
maritima) 		PF02091
(tRNA-synt_2e) 		7 ALA A  31
GLY A  32
THR A  33
GLN A  76
GLN A  78
GLU A 156
THR A 158
 None
 0.58A 3rglA-1j5wA:
38.8		 3rglA-1j5wA:
57.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1koe ENDOSTATIN

(Mus musculus) 		PF06482
(Endostatin) 		4 ALA A 293
GLY A 278
THR A 277
GLN A 279
 None
 0.91A 3rglA-1koeA:
undetectable		 3rglA-1koeA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1njk HYPOTHETICAL PROTEIN
YBAW

(Escherichia
coli) 		PF13279
(4HBT_2) 		4 GLN A   2
GLN A   4
GLU A  93
THR A  71
 None
 0.93A 3rglA-1njkA:
undetectable		 3rglA-1njkA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ALA A  29
GLY A  30
THR A  27
GLN A 295
 None
 0.90A 3rglA-1nr0A:
undetectable		 3rglA-1nr0A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovw ENDOGLUCANASE I

(Fusarium
oxysporum) 		PF00840
(Glyco_hydro_7) 		4 GLY A 222
GLN A 191
GLU A 227
THR A 224
 None
 0.91A 3rglA-1ovwA:
undetectable		 3rglA-1ovwA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR

(Homo sapiens;
Homo sapiens) 		PF00386
(C1q)
PF00386
(C1q) 		4 GLY B 184
THR B 144
GLN A 142
THR B 182
 None
 0.91A 3rglA-1pk6B:
undetectable		 3rglA-1pk6B:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qe0 HISTIDINE--TRNA
LIGASE

(Staphylococcus
aureus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 GLY A  81
THR A  82
ARG A 112
GLN A 126
 None
 0.50A 3rglA-1qe0A:
10.0		 3rglA-1qe0A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A  34
GLY A  93
THR A  92
THR A  98
 None
None
EDO  A2001 ( 4.6A)
None
 0.81A 3rglA-1rx0A:
undetectable		 3rglA-1rx0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1d APYRASE

(Homo sapiens) 		PF06079
(Apyrase) 		4 ALA A  31
GLY A  32
THR A  29
THR A  65
 None
 0.92A 3rglA-1s1dA:
undetectable		 3rglA-1s1dA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s35 SPECTRIN BETA CHAIN,
ERYTHROCYTE

(Homo sapiens) 		PF00435
(Spectrin) 		4 ALA A1152
GLY A1149
THR A1148
GLN A1081
 None
 0.94A 3rglA-1s35A:
2.6		 3rglA-1s35A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tza APAG PROTEIN

(Shewanella
oneidensis) 		PF04379
(DUF525) 		4 ALA A  66
GLY A  65
THR A  48
GLN A  64
 ALA  A  66 ( 0.0A)
GLY  A  65 ( 0.0A)
THR  A  48 ( 0.8A)
GLN  A  64 ( 0.6A)
 0.92A 3rglA-1tzaA:
undetectable		 3rglA-1tzaA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		4 GLY A 314
THR A  16
GLU A  44
THR A 310
 None
 0.94A 3rglA-1ulvA:
undetectable		 3rglA-1ulvA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy7 STRINGENT STARVATION
PROTEIN A

(Yersinia pestis) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 GLY A  16
ARG A 167
GLN A  40
THR A 201
 None
 0.91A 3rglA-1yy7A:
undetectable		 3rglA-1yy7A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		4 ALA A 237
GLY A 238
GLU A 160
THR A 159
 None
 0.92A 3rglA-1z6rA:
undetectable		 3rglA-1z6rA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoq INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF10401
(IRF-3) 		4 GLN A 214
GLN A 217
GLU A 205
THR A 207
 None
 0.93A 3rglA-1zoqA:
undetectable		 3rglA-1zoqA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN

(Neisseria
meningitidis) 		PF00359
(PTS_EIIA_2) 		4 ALA A  64
GLY A  58
THR A  57
GLU A  52
 None
 0.92A 3rglA-2a0jA:
undetectable		 3rglA-2a0jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 4 ALA A 129
THR A 131
GLN A 168
THR A 151
 None
 0.83A 3rglA-2cl2A:
undetectable		 3rglA-2cl2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5a LIPOYLTRANSFERASE 1

(Bos taurus) 		no annotation 4 GLY A  78
THR A  79
GLN A  52
GLU A  57
 LAQ  A2001 ( 3.2A)
None
None
None
 0.93A 3rglA-2e5aA:
5.9		 3rglA-2e5aA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es3 THROMBOSPONDIN-1

(Homo sapiens) 		PF02210
(Laminin_G_2) 		4 ALA A 107
GLY A 108
THR A 109
GLU A 126
 None
 0.93A 3rglA-2es3A:
undetectable		 3rglA-2es3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 399
GLY A 398
ARG A 386
GLN A 252
 None
 0.74A 3rglA-2hz0A:
undetectable		 3rglA-2hz0A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7q MCMV TEGUMENT
PROTEIN M48 ENCODED
UBIQUITIN- SPECIFIC
PROTEASE, M48USP

(Murid
betaherpesvirus
1) 		PF04843
(Herpes_teg_N) 		4 ALA A  90
GLY A  91
THR A  88
THR A  93
 None
 0.89A 3rglA-2j7qA:
undetectable		 3rglA-2j7qA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jks BRADYZOITE SURFACE
ANTIGEN BSR4

(Toxoplasma
gondii) 		PF04092
(SAG) 		4 ALA A  81
GLY A  80
GLN A 139
THR A 152
 None
 0.94A 3rglA-2jksA:
undetectable		 3rglA-2jksA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxm CYTOCHROME F

(Prochlorothrix
hollandica) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		4 GLY B  17
THR B  16
GLN B 238
GLU B  14
 None
 0.95A 3rglA-2jxmB:
undetectable		 3rglA-2jxmB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k35 HYDRAMACIN-1

(Hydra vulgaris) 		PF14865
(Macin) 		4 GLY A  21
THR A  22
ARG A  30
GLN A  17
 None
 0.92A 3rglA-2k35A:
undetectable		 3rglA-2k35A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE

(Pseudomonas sp.
101) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLY A  51
GLN A 341
GLN A  96
THR A 336
 None
 0.94A 3rglA-2nadA:
undetectable		 3rglA-2nadA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		4 ALA A  95
GLY A  96
THR A  97
GLN A 169
 None
SKP  A 501 (-3.8A)
SKP  A 501 (-3.8A)
SKP  A 501 (-3.6A)
 0.84A 3rglA-2o0xA:
undetectable		 3rglA-2o0xA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug) 		4 GLY A 138
THR A 151
GLN A  69
THR A 133
 None
 0.94A 3rglA-2o5pA:
undetectable		 3rglA-2o5pA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oml RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 ALA A  93
GLY A  92
ARG A  97
THR A  89
 None
 0.88A 3rglA-2omlA:
undetectable		 3rglA-2omlA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p28 INTEGRIN BETA-2
INTEGRIN BETA-2

(Homo sapiens;
Homo sapiens) 		PF17205
(PSI_integrin)
no annotation 		4 GLN B 418
GLN A  66
GLU A  64
THR A  82
 None
 0.82A 3rglA-2p28B:
undetectable		 3rglA-2p28B:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrt RIBONUCLEASE E

(Escherichia
coli) 		PF00575
(S1)
PF10150
(RNase_E_G) 		4 ALA A 307
GLY A 289
GLU A 325
THR A 322
 None
 0.91A 3rglA-2vrtA:
undetectable		 3rglA-2vrtA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkl APOLIPOPROTEIN M

(Mus musculus) 		PF11032
(ApoM) 		5 ALA A  78
GLY A  76
GLN A  81
GLN A  83
THR A 101
 None
 1.15A 3rglA-2xklA:
undetectable		 3rglA-2xklA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		4 GLY A  69
THR A  70
GLN A  75
GLN A  68
 None
 0.84A 3rglA-2ykyA:
undetectable		 3rglA-2ykyA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a77 INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF10401
(IRF-3) 		4 GLN A 214
GLN A 217
GLU A 205
THR A 207
 None
 0.82A 3rglA-3a77A:
undetectable		 3rglA-3a77A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		4 GLY A 264
THR A 263
GLN A 244
THR A 277
 None
 0.71A 3rglA-3c9fA:
undetectable		 3rglA-3c9fA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9w PUTATIVE
ACETYLTRANSFERASE

(Nocardia
farcinica) 		PF00797
(Acetyltransf_2) 		4 ALA A 117
GLY A 105
THR A 104
THR A 194
 None
 0.95A 3rglA-3d9wA:
undetectable		 3rglA-3d9wA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drx BTB/POZ
DOMAIN-CONTAINING
PROTEIN KCTD5

(Homo sapiens) 		PF02214
(BTB_2) 		4 ALA A  89
GLY A  88
THR A  87
GLU A  86
 None
 0.65A 3rglA-3drxA:
undetectable		 3rglA-3drxA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drz BTB/POZ
DOMAIN-CONTAINING
PROTEIN KCTD5

(Homo sapiens) 		PF02214
(BTB_2) 		4 ALA A  89
GLY A  88
THR A  87
GLU A  86
 None
 0.81A 3rglA-3drzA:
undetectable		 3rglA-3drzA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhc ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD) 		4 ALA B 146
GLY B 143
THR B 142
GLN B 119
 None
 0.86A 3rglA-3fhcB:
undetectable		 3rglA-3fhcB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE

(Moraxella sp.) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLY A  51
GLN A 341
GLN A  96
THR A 336
 None
 0.91A 3rglA-3fn4A:
undetectable		 3rglA-3fn4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyn SPERM LYSIN

(Haliotis
fulgens) 		PF01303
(Egg_lysin) 		4 ALA A  90
GLY A  89
THR A  86
ARG A  94
 None
 0.92A 3rglA-3lynA:
undetectable		 3rglA-3lynA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5m ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 GLY A 225
THR A 223
ARG A 162
GLN A 159
GLU A 219
 None
 1.26A 3rglA-3n5mA:
undetectable		 3rglA-3n5mA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr1 HD DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF13328
(HD_4) 		4 ALA A  80
GLY A  79
ARG A  84
GLN A  81
 None
 0.90A 3rglA-3nr1A:
undetectable		 3rglA-3nr1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvn PLEXIN-C1

(Homo sapiens) 		PF01437
(PSI) 		4 ALA B 133
GLY B 132
THR B 151
ARG B  81
 None
 0.91A 3rglA-3nvnB:
undetectable		 3rglA-3nvnB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		4 ALA A  95
GLY A  96
THR A  97
GLN A 172
 None
GPJ  A 429 (-3.2A)
GPJ  A 429 ( 4.0A)
GPJ  A 429 (-3.0A)
 0.89A 3rglA-3nvsA:
undetectable		 3rglA-3nvsA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 PLEXIN-B1

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		4 GLY B 125
GLN B  57
GLU B  65
THR B  46
 None
 0.91A 3rglA-3ol2B:
undetectable		 3rglA-3ol2B:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pw3 AMINOPEPTIDASE C

(Parabacteroides
distasonis) 		PF03051
(Peptidase_C1_2) 		4 ALA A  53
GLY A  54
THR A  55
GLN A 107
 None
 0.94A 3rglA-3pw3A:
undetectable		 3rglA-3pw3A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se5 CELL FILAMENTATION
PROTEIN FIC-RELATED
PROTEIN

(Neisseria
meningitidis) 		PF02661
(Fic) 		4 ALA A  40
GLY A  41
THR A  38
GLN A  44
 None
None
None
P6G  A 202 ( 3.5A)
 0.90A 3rglA-3se5A:
undetectable		 3rglA-3se5A:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ufg GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT

(Campylobacter
jejuni) 		PF02091
(tRNA-synt_2e) 		8 ALA A  31
GLY A  32
THR A  33
ARG A  58
GLN A  76
GLN A  78
GLU A 156
THR A 158
 ATP  A 288 (-3.7A)
None
ATP  A 288 (-3.7A)
ATP  A 288 (-2.9A)
ATP  A 288 ( 4.3A)
ATP  A 288 ( 4.6A)
ATP  A 288 (-3.8A)
ATP  A 288 ( 3.9A)
 0.30A 3rglA-3ufgA:
47.1		 3rglA-3ufgA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urr PTS IIA-LIKE
NITROGEN-REGULATORY
PROTEIN PTSN

(Burkholderia
thailandensis) 		PF00359
(PTS_EIIA_2) 		4 ALA A  64
GLY A  58
THR A  57
GLU A  52
 None
 0.87A 3rglA-3urrA:
undetectable		 3rglA-3urrA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		4 ALA A 419
THR A 417
GLN A 545
THR A 557
 None
WYQ  A 701 (-4.5A)
None
None
 0.83A 3rglA-3v94A:
undetectable		 3rglA-3v94A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp5 CDBFV

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		4 GLY A 173
THR A 174
ARG A 166
GLN A   1
 None
 0.92A 3rglA-3wp5A:
undetectable		 3rglA-3wp5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 ALA A 442
GLY A 425
THR A 426
ARG A 445
GLU A 427
 None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
 1.38A 3rglA-3zyxA:
undetectable		 3rglA-3zyxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj4 AMPDH2

(Pseudomonas
aeruginosa) 		PF01471
(PG_binding_1)
PF01510
(Amidase_2) 		4 GLY A 219
THR A 218
GLN A 205
THR A 225
 None
 0.93A 3rglA-4bj4A:
undetectable		 3rglA-4bj4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bru ATP-DEPENDENT RNA
HELICASE DHH1

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ALA A  98
GLY A  95
THR A  94
GLN A  73
 None
 0.96A 3rglA-4bruA:
undetectable		 3rglA-4bruA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crh SH3KBP1-BINDING
PROTEIN 1

(Homo sapiens) 		PF02214
(BTB_2) 		4 ALA A  62
GLY A  61
THR A  60
GLU A  59
 None
 0.72A 3rglA-4crhA:
undetectable		 3rglA-4crhA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fch OUTER MEMBRANE
PROTEIN SUSE

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE) 		4 ALA A 381
GLY A 382
THR A 383
GLU A 346
 None
 0.66A 3rglA-4fchA:
undetectable		 3rglA-4fchA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE

(Homo sapiens) 		PF00291
(PALP) 		4 ALA A  23
GLY A  24
THR A  25
GLN A 283
 None
 0.70A 3rglA-4h27A:
undetectable		 3rglA-4h27A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8i HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF16227
(DUF4886) 		4 ALA A 207
GLY A 205
THR A 206
GLN A 158
 None
 0.94A 3rglA-4i8iA:
undetectable		 3rglA-4i8iA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihq FLAI ATPASE

(Sulfolobus
acidocaldarius) 		PF00437
(T2SSE) 		4 ALA A 336
GLY A 335
ARG A 338
GLU A 293
 PO4  A 603 ( 4.0A)
None
PO4  A 603 ( 3.1A)
MG  A 602 ( 4.1A)
 0.71A 3rglA-4ihqA:
undetectable		 3rglA-4ihqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 GLY A 571
THR A 570
GLN A 573
GLU A 599
 None
 0.95A 3rglA-4jcmA:
undetectable		 3rglA-4jcmA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		4 ALA A  54
GLY A  55
THR A  56
THR A 177
 None
 0.76A 3rglA-4jypA:
undetectable		 3rglA-4jypA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1

(Rattus
norvegicus) 		PF00245
(Alk_phosphatase) 		4 GLY A 203
THR A 272
GLN A 152
GLU A 273
 None
 0.91A 3rglA-4kjdA:
undetectable		 3rglA-4kjdA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhz PUTATIVE GLUTATHIONE
S-TRANSFERASE ENZYME
WITH
THIOREDOXIN-LIKE
DOMAIN

(Bradyrhizobium
sp. BTAi1) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ALA A 213
THR A 209
ARG A 217
GLU A 165
 None
 0.96A 3rglA-4nhzA:
undetectable		 3rglA-4nhzA:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofz TREHALOSE-PHOSPHATAS
E

(Brugia malayi) 		no annotation 4 ALA A 254
GLY A 255
GLN A 332
THR A 339
 None
 0.84A 3rglA-4ofzA:
undetectable		 3rglA-4ofzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ony EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 5

(Brucella
melitensis) 		PF00496
(SBP_bac_5) 		4 GLY A 399
THR A 397
ARG A 454
GLU A 338
 None
 0.96A 3rglA-4onyA:
undetectable		 3rglA-4onyA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Roseobacter
denitrificans) 		PF03480
(DctP) 		4 ALA A 180
GLY A 177
THR A 176
GLU A 173
 None
 0.92A 3rglA-4ovqA:
undetectable		 3rglA-4ovqA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p78 HICB3 ANTITOXIN

(Yersinia pestis) 		PF15919
(HicB_lk_antitox) 		4 ALA A  27
GLY A  28
GLU A  12
THR A  10
 None
 0.77A 3rglA-4p78A:
undetectable		 3rglA-4p78A:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rv4 OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
anthracis) 		PF00156
(Pribosyltran) 		5 ALA A  74
GLY A  75
THR A  71
ARG A  38
GLU A 120
 PRP  A 301 (-3.3A)
None
PRP  A 301 ( 4.7A)
PRP  A 301 (-3.7A)
PRP  A 301 (-2.9A)
 1.21A 3rglA-4rv4A:
undetectable		 3rglA-4rv4A:
30.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 ALA A 241
GLY A 242
THR A 243
GLU A 116
 None
 0.81A 3rglA-4xixA:
undetectable		 3rglA-4xixA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		4 THR A 465
ARG A 496
GLU A 410
THR A 409
 None
 0.93A 3rglA-5a29A:
undetectable		 3rglA-5a29A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6r BTB/POZ
DOMAIN-CONTAINING
PROTEIN KCTD17

(Homo sapiens) 		PF02214
(BTB_2) 		4 ALA A  75
GLY A  74
THR A  73
GLU A  72
 None
 0.75A 3rglA-5a6rA:
undetectable		 3rglA-5a6rA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5an9 60S ACIDIC RIBOSOMAL
PROTEIN P0

(Dictyostelium
discoideum) 		PF00466
(Ribosomal_L10) 		4 GLY C 163
THR C 162
GLN C  83
GLU C  30
 None
 0.91A 3rglA-5an9C:
undetectable		 3rglA-5an9C:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4w PLEXIN-B1

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		4 GLY A 125
GLN A  57
GLU A  65
THR A  46
 None
 0.93A 3rglA-5b4wA:
undetectable		 3rglA-5b4wA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbk SHHTL5

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		4 ALA A  54
GLY A  55
THR A  56
THR A 177
 None
 0.76A 3rglA-5cbkA:
undetectable		 3rglA-5cbkA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC

(Neisseria
meningitidis) 		PF02661
(Fic) 		4 ALA A  40
GLY A  41
THR A  38
GLN A  44
 None
 0.89A 3rglA-5cglA:
undetectable		 3rglA-5cglA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvc SERINE RACEMASE

(Zea mays) 		PF00291
(PALP) 		4 ALA A  71
GLY A  70
THR A 167
GLN A 171
 None
 0.93A 3rglA-5cvcA:
undetectable		 3rglA-5cvcA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF13476
(AAA_23) 		4 ALA A  64
GLY A  63
ARG A  13
GLN A 111
 AGS  A1402 (-4.9A)
None
AGS  A1402 (-4.2A)
None
 0.88A 3rglA-5dacA:
undetectable		 3rglA-5dacA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3i HISTIDINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 GLY A  86
THR A  87
ARG A 115
GLN A 129
 None
HIS  A 502 (-3.4A)
ATP  A 501 ( 2.5A)
HIS  A 502 ( 3.1A)
 0.88A 3rglA-5e3iA:
10.4		 3rglA-5e3iA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3i HISTIDINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 GLY A  86
THR A  87
GLN A 129
GLU A 133
 None
HIS  A 502 (-3.4A)
HIS  A 502 ( 3.1A)
HIS  A 502 (-2.6A)
 0.62A 3rglA-5e3iA:
10.4		 3rglA-5e3iA:
24.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT

(Aquifex
aeolicus) 		PF02091
(tRNA-synt_2e) 		8 ALA A  31
GLY A  32
THR A  33
ARG A  58
GLN A  76
GLN A  78
GLU A 156
THR A 158
 G5A  A 300 ( 3.9A)
None
G5A  A 300 (-3.9A)
G5A  A 300 (-3.1A)
G5A  A 300 (-3.3A)
G5A  A 300 ( 4.6A)
G5A  A 300 (-3.0A)
G5A  A 300 (-3.4A)
 0.40A 3rglA-5f5wA:
40.8		 3rglA-5f5wA:
59.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		PF01019
(G_glu_transpept)
PF01019
(G_glu_transpept) 		4 ALA A  45
GLY A  53
GLN B 359
THR A 107
 None
 0.89A 3rglA-5hftA:
undetectable		 3rglA-5hftA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B

(Homo sapiens) 		PF00386
(C1q) 		4 GLY A 368
THR A 328
GLN A  55
THR A 366
 None
 0.94A 3rglA-5hkjA:
undetectable		 3rglA-5hkjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l56 PLEXIN-A1

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		5 ALA A 986
GLY A 872
THR A 871
ARG A1004
THR A 878
 None
 1.49A 3rglA-5l56A:
undetectable		 3rglA-5l56A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7n PLEXIN-A1

(Mus musculus) 		PF01833
(TIG) 		5 ALA A 986
GLY A 872
THR A 871
ARG A1004
THR A 878
 None
 1.43A 3rglA-5l7nA:
undetectable		 3rglA-5l7nA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 ALA b 259
GLY b 258
THR b 255
ARG b 263
 None
 0.85A 3rglA-5l9wb:
undetectable		 3rglA-5l9wb:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m41 NIGRITOXINE

(Vibrio
nigripulchritudo) 		no annotation 4 ALA A 334
GLY A 366
THR A 365
THR A 440
 None
 0.94A 3rglA-5m41A:
undetectable		 3rglA-5m41A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thw DEACYLASE

(Burkholderia
multivorans) 		PF01546
(Peptidase_M20) 		4 ALA A 369
GLY A 370
GLN A 226
GLU A 141
 URP  A 503 (-3.2A)
URP  A 503 (-3.5A)
URP  A 503 (-3.4A)
URP  A 503 ( 2.9A)
 0.95A 3rglA-5thwA:
undetectable		 3rglA-5thwA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vps SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Burkholderia
ambifaria) 		PF13561
(adh_short_C2) 		4 ALA A 165
GLY A 162
THR A 161
ARG A 169
 None
 0.95A 3rglA-5vpsA:
undetectable		 3rglA-5vpsA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A 765
THR A 766
ARG A 803
THR A 814
 None
 0.91A 3rglA-5vywA:
undetectable		 3rglA-5vywA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsl KERATINASE

(Meiothermus
taiwanensis) 		no annotation 4 GLY A  30
THR A  29
ARG A  92
GLN A 239
 None
 0.66A 3rglA-5wslA:
undetectable		 3rglA-5wslA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z95 -

(-) 		no annotation 4 ALA A  54
GLY A  55
THR A  56
THR A 177
 None
 0.78A 3rglA-5z95A:
undetectable		 3rglA-5z95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e9p -

(-) 		no annotation 4 ALA A 261
GLY A 258
THR A 257
ARG A 265
 None
 0.96A 3rglA-6e9pA:
undetectable		 3rglA-6e9pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL
ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei;
Trypanosoma
brucei) 		no annotation
no annotation 		4 GLY A  36
THR A  37
GLU D 292
THR D 289
 None
 0.94A 3rglA-6f5dA:
undetectable		 3rglA-6f5dA:
undetectable