SIMILAR PATTERNS OF AMINO ACIDS FOR 3RGF_A_BAXA465_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0i D-AMINO ACID OXIDASE

(Rhodotorula
toruloides) 		PF01266
(DAO) 		4 LEU A1010
VAL A1175
VAL A1162
ASP A1170
 None
None
FAD  A1363 (-4.0A)
None
 0.86A 3rgfA-1c0iA:
0.0		 3rgfA-1c0iA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4x PROTEIN
(2-HYDROXY-6-OXO-6-P
HENYLHEXA-2,4-DIENOA
TE HYDROLASE)

(Rhodococcus
jostii) 		PF12697
(Abhydrolase_6) 		5 LEU A  33
VAL A 107
VAL A  60
LEU A 228
MET A 276
 None
 1.28A 3rgfA-1c4xA:
0.0		 3rgfA-1c4xA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		4 LEU A 325
VAL A  78
LEU A 356
ASP A 318
 None
None
None
ADN  A 375 ( 3.1A)
 0.77A 3rgfA-1dgmA:
0.0		 3rgfA-1dgmA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtp DIPHTHERIA TOXIN

(Corynephage
beta) 		PF02763
(Diphtheria_C) 		4 LEU A  92
VAL A 134
LEU A  88
ASP A 129
 None
 0.92A 3rgfA-1dtpA:
0.0		 3rgfA-1dtpA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N) 		4 LEU A 118
VAL A  12
VAL A 196
ASP A  43
 None
 0.85A 3rgfA-1fi4A:
0.0		 3rgfA-1fi4A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g68 BETA-LACTAMASE PSE-4

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		4 VAL A 261
LEU A 190
ASP A 233
MET A 211
 None
 0.92A 3rgfA-1g68A:
0.0		 3rgfA-1g68A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyq CELL DIVISION
INHIBITOR (MIND-1)

(Archaeoglobus
fulgidus) 		PF01656
(CbiA) 		4 LEU A  59
VAL A  83
VAL A 103
ASP A  70
 None
 0.80A 3rgfA-1hyqA:
0.0		 3rgfA-1hyqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		4 LEU A 611
VAL A 597
LEU A 407
ASP A 390
 None
 0.95A 3rgfA-1i6qA:
0.0		 3rgfA-1i6qA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 LEU A  46
VAL A  42
VAL A  61
LEU A 111
 None
 0.96A 3rgfA-1jqoA:
0.0		 3rgfA-1jqoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khi HEX1

(Neurospora
crassa) 		PF01287
(eIF-5a) 		4 LEU A 141
VAL A 131
VAL A 108
LEU A  74
 None
 0.90A 3rgfA-1khiA:
undetectable		 3rgfA-1khiA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		5 LEU A  20
VAL A  73
LEU A 240
ASP A  16
MET A  15
 None
 1.13A 3rgfA-1ktnA:
undetectable		 3rgfA-1ktnA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mab PROTEIN (F1-ATPASE
BETA CHAIN)

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 LEU B  69
VAL B  16
VAL B  38
LEU B 271
 None
 0.93A 3rgfA-1mabB:
undetectable		 3rgfA-1mabB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 LEU A 607
VAL A 808
LEU A1219
ASP A 832
 None
 0.92A 3rgfA-1n5xA:
undetectable		 3rgfA-1n5xA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvt SHIKIMATE
5'-DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 LEU A 191
VAL A 132
VAL A 215
LEU A 147
 None
 0.73A 3rgfA-1nvtA:
undetectable		 3rgfA-1nvtA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		4 LEU A  16
VAL A  26
VAL A  46
ASP A  12
 None
 0.93A 3rgfA-1o54A:
undetectable		 3rgfA-1o54A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT

(Acidaminococcus
fermentans) 		PF01039
(Carboxyl_trans) 		4 LYS A 393
VAL A 409
LEU A 462
MET A 346
 None
 0.95A 3rgfA-1pixA:
undetectable		 3rgfA-1pixA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 LEU A 513
VAL A 497
VAL A 486
LEU A 615
 None
 0.86A 3rgfA-1ps9A:
undetectable		 3rgfA-1ps9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 818
VAL A 675
LEU A 668
ASP A 829
 None
 0.82A 3rgfA-1rjbA:
20.3		 3rgfA-1rjbA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rm8 MATRIX
METALLOPROTEINASE-16

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 LEU A 278
VAL A 162
VAL A 245
ASP A 157
 None
 0.94A 3rgfA-1rm8A:
undetectable		 3rgfA-1rm8A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 391
LEU A 413
VAL A 478
LEU A 489
 None
 0.76A 3rgfA-1snxA:
20.8		 3rgfA-1snxA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2f L-LACTATE
DEHYDROGENASE B
CHAIN

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 330
VAL A 146
VAL A 110
ASP A 141
 None
 0.96A 3rgfA-1t2fA:
undetectable		 3rgfA-1t2fA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 799
VAL A 654
LEU A 647
ASP A 810
 STI  A   3 (-4.4A)
STI  A   3 (-4.3A)
None
STI  A   3 (-3.9A)
 0.64A 3rgfA-1t46A:
8.3		 3rgfA-1t46A:
25.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 LYS A  32
LEU A  57
VAL A 121
LEU A 132
 None
 0.67A 3rgfA-1v0bA:
24.9		 3rgfA-1v0bA:
33.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0h 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T) 		4 VAL A 157
LEU A 227
ASP A 134
MET A 235
 None
None
MG  A1000 (-2.0A)
None
 0.96A 3rgfA-1w0hA:
undetectable		 3rgfA-1w0hA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE

(Escherichia
coli) 		PF00171
(Aldedh) 		4 LEU A 296
VAL A 255
VAL A 265
ASP A 260
 None
 0.94A 3rgfA-1wnbA:
undetectable		 3rgfA-1wnbA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 LEU A 137
VAL A 252
VAL A 159
LEU A 123
 None
 0.84A 3rgfA-1wytA:
undetectable		 3rgfA-1wytA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		4 LEU A 170
VAL A 181
VAL A 103
MET A 158
 None
 0.92A 3rgfA-1xviA:
undetectable		 3rgfA-1xviA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqb UBIQUILIN 3

(Homo sapiens) 		PF00240
(ubiquitin) 		4 LEU A  46
VAL A  37
VAL A  87
ASP A  34
 None
 0.92A 3rgfA-1yqbA:
undetectable		 3rgfA-1yqbA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		4 VAL A 261
LEU A 190
ASP A 233
MET A 211
 None
 0.93A 3rgfA-1zg4A:
undetectable		 3rgfA-1zg4A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Homo sapiens) 		PF01424
(R3H)
PF04857
(CAF1) 		4 VAL A 284
VAL A 293
ASP A 324
MET A 328
 None
 0.87A 3rgfA-2a1rA:
undetectable		 3rgfA-2a1rA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 113
VAL A 142
LEU A 212
ASP A 226
 None
 0.92A 3rgfA-2ac5A:
20.2		 3rgfA-2ac5A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1

(Saccharomyces
cerevisiae) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		4 VAL A 395
VAL A 368
LEU A 470
MET A 437
 None
 0.91A 3rgfA-2bmbA:
undetectable		 3rgfA-2bmbA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 LEU A1334
VAL A1358
LEU A1326
ASP A1128
 None
 0.85A 3rgfA-2bruA:
undetectable		 3rgfA-2bruA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3d 2-OXOPROPYL-COM
REDUCTASE

(Xanthobacter
autotrophicus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 325
VAL A 348
VAL A 160
LEU A 341
 None
 0.97A 3rgfA-2c3dA:
undetectable		 3rgfA-2c3dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chr CHLOROMUCONATE
CYCLOISOMERASE

(Cupriavidus
necator) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 218
VAL A 265
LEU A 257
ASP A 245
 None
None
None
MN  A 400 ( 3.1A)
 0.88A 3rgfA-2chrA:
undetectable		 3rgfA-2chrA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		4 LEU A 163
VAL A 135
VAL A 171
ASP A 140
 None
 0.96A 3rgfA-2d0oA:
undetectable		 3rgfA-2d0oA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 LYS A 484
LEU A 425
VAL A 419
ASP A 395
 None
 0.91A 3rgfA-2d3tA:
undetectable		 3rgfA-2d3tA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9f FK506-BINDING
PROTEIN 8 VARIANT

(Homo sapiens) 		PF00254
(FKBP_C) 		4 LEU A  73
VAL A  88
VAL A  42
LEU A  11
 None
 0.87A 3rgfA-2d9fA:
undetectable		 3rgfA-2d9fA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi9 OUTER MEMBRANE
PROTEIN

(Bartonella
henselae) 		PF04430
(DUF498) 		4 LEU A 113
VAL A  71
LEU A  91
ASP A  99
 None
 0.87A 3rgfA-2fi9A:
undetectable		 3rgfA-2fi9A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 LEU A 546
VAL A 728
LEU A 370
ASP A 522
 None
 0.94A 3rgfA-2fuqA:
undetectable		 3rgfA-2fuqA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 LEU A  71
VAL A  89
VAL A 153
ASP A 121
 None
 0.81A 3rgfA-2hdiA:
undetectable		 3rgfA-2hdiA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 LEU A  94
VAL A 482
LEU A 568
ASP A 556
 None
 0.70A 3rgfA-2hdiA:
undetectable		 3rgfA-2hdiA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 371
VAL A 301
LEU A 295
ASP A 382
 1BM  A 499 (-4.4A)
None
None
1BM  A 499 (-4.4A)
 0.86A 3rgfA-2hk5A:
15.9		 3rgfA-2hk5A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR

(Escherichia
coli) 		PF03466
(LysR_substrate) 		4 LEU A 240
VAL A 168
VAL A 227
LEU A 175
 None
 0.77A 3rgfA-2hxrA:
undetectable		 3rgfA-2hxrA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A  29
VAL A  12
VAL A 330
LEU A  78
 None
 0.82A 3rgfA-2i3aA:
undetectable		 3rgfA-2i3aA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihm DNA POLYMERASE MU

(Mus musculus) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 LEU A 298
VAL A 417
LEU A 347
ASP A 420
 None
None
None
NA  A 902 (-3.8A)
 0.85A 3rgfA-2ihmA:
undetectable		 3rgfA-2ihmA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw0 CHITIN DEACETYLASE

(Colletotrichum
lindemuthianum) 		PF01522
(Polysacc_deac_1) 		4 LYS A  29
LEU A  43
VAL A 232
LEU A 100
 None
 0.92A 3rgfA-2iw0A:
undetectable		 3rgfA-2iw0A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE

(Mus musculus) 		PF02434
(Fringe) 		4 LEU A 155
VAL A 272
VAL A 167
LEU A 263
 None
 0.96A 3rgfA-2j0aA:
undetectable		 3rgfA-2j0aA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j9l CHLORIDE CHANNEL
PROTEIN 5

(Homo sapiens) 		PF00571
(CBS) 		4 LEU A 640
VAL A 635
VAL A 608
LEU A 685
 None
 0.91A 3rgfA-2j9lA:
undetectable		 3rgfA-2j9lA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh3 RIBOSOMAL PROTEIN
S2-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF01903
(CbiX) 		4 LEU A  57
VAL A  60
VAL A  67
ASP A  64
 None
 0.86A 3rgfA-2jh3A:
undetectable		 3rgfA-2jh3A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00342
(PGI) 		4 LYS A 259
LEU A 408
VAL A 550
LEU A 151
 None
 0.95A 3rgfA-2o2cA:
undetectable		 3rgfA-2o2cA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 371
VAL A 301
LEU A 295
ASP A 382
 1N8  A 501 ( 4.3A)
None
1N8  A 501 ( 3.9A)
1N8  A 501 ( 3.3A)
 0.62A 3rgfA-2og8A:
21.7		 3rgfA-2og8A:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 273
LEU A 295
LEU A 371
ASP A 382
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.9A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
 0.96A 3rgfA-2og8A:
21.7		 3rgfA-2og8A:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyr UPF0341 PROTEIN YHIQ

(Shigella
flexneri) 		PF04445
(SAM_MT) 		4 VAL A  92
VAL A 216
LEU A 147
ASP A 102
 None
None
None
SAH  A 301 (-3.4A)
 0.93A 3rgfA-2oyrA:
undetectable		 3rgfA-2oyrA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbj OB TCR

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU D 137
VAL D  33
VAL D 103
LEU D 243
 None
 0.92A 3rgfA-2wbjD:
undetectable		 3rgfA-2wbjD:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS C  78
LEU C 105
VAL C 110
LEU C 183
 ANP  C   2 (-3.6A)
None
None
None
 0.60A 3rgfA-2wtkC:
8.6		 3rgfA-2wtkC:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyo GLUTATHIONE
SYNTHETASE

(Trypanosoma
brucei) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 VAL A 320
VAL A 277
LEU A 113
ASP A 213
 None
 0.97A 3rgfA-2wyoA:
undetectable		 3rgfA-2wyoA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		4 LEU A 184
VAL A 215
VAL A 196
LEU A 305
 None
 0.95A 3rgfA-2x4gA:
undetectable		 3rgfA-2x4gA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN

(Streptomyces
coelicolor) 		PF01497
(Peripla_BP_2) 		4 LEU A 213
VAL A 254
LEU A 180
ASP A 245
 None
 0.86A 3rgfA-2x4lA:
undetectable		 3rgfA-2x4lA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis) 		PF01593
(Amino_oxidase) 		4 LEU A  68
VAL A  61
VAL A 217
LEU A 206
 None
 0.83A 3rgfA-2yg6A:
undetectable		 3rgfA-2yg6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 220
VAL A 227
VAL A 264
LEU A 298
 None
 0.96A 3rgfA-2yxzA:
undetectable		 3rgfA-2yxzA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		4 LEU A 544
VAL A 549
VAL A 578
ASP A 553
 None
 0.67A 3rgfA-3a5iA:
undetectable		 3rgfA-3a5iA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 LEU A 146
VAL A 253
VAL A 115
ASP A  76
 None
 0.97A 3rgfA-3actA:
undetectable		 3rgfA-3actA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwn L-TRYPTOPHAN
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF04864
(Alliinase_C) 		5 LEU A 330
VAL A 364
VAL A 298
LEU A 367
MET A 287
 None
 1.44A 3rgfA-3bwnA:
undetectable		 3rgfA-3bwnA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8u FRUCTOKINASE

(Ruegeria sp.
TM1040) 		no annotation 4 LEU A  45
VAL A 125
VAL A  10
LEU A  94
 None
 0.87A 3rgfA-3c8uA:
undetectable		 3rgfA-3c8uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq9 UNCHARACTERIZED
PROTEIN LP_1622

(Lactobacillus
plantarum) 		PF04263
(TPK_catalytic) 		4 LEU A  66
VAL A  47
LEU A  83
ASP A  50
 None
 0.93A 3rgfA-3cq9A:
undetectable		 3rgfA-3cq9A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF01063
(Aminotran_4) 		4 LEU A 238
VAL A 235
LEU A 109
ASP A 152
 None
 0.73A 3rgfA-3cswA:
undetectable		 3rgfA-3cswA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dj4 BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 LEU A 118
VAL A  40
VAL A 184
ASP A 114
 None
None
None
MG  A 496 ( 2.6A)
 0.95A 3rgfA-3dj4A:
undetectable		 3rgfA-3dj4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 LYS A 665
VAL A 694
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.5A)
None
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.52A 3rgfA-3dkoA:
undetectable		 3rgfA-3dkoA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egh SPINOPHILIN

(Rattus
norvegicus) 		PF00595
(PDZ) 		4 LEU C 557
VAL C 560
VAL C 568
LEU C 521
 None
 0.95A 3rgfA-3eghC:
undetectable		 3rgfA-3eghC:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7w PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Thermobifida
fusca) 		PF03881
(Fructosamin_kin) 		4 LEU A 230
VAL A 199
LEU A 246
ASP A 221
 None
 0.85A 3rgfA-3f7wA:
5.5		 3rgfA-3f7wA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7w PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Thermobifida
fusca) 		PF03881
(Fructosamin_kin) 		4 LEU A 230
VAL A 236
VAL A 199
ASP A 221
 None
 0.90A 3rgfA-3f7wA:
5.5		 3rgfA-3f7wA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE

(Pseudomonas
protegens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 224
VAL A 271
LEU A 263
ASP A 251
 None
None
None
MG  A1001 ( 3.3A)
 0.88A 3rgfA-3fj4A:
undetectable		 3rgfA-3fj4A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g64 PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
coelicolor) 		PF00378
(ECH_1) 		4 LEU A  54
VAL A  60
VAL A  19
LEU A 214
 None
 0.93A 3rgfA-3g64A:
undetectable		 3rgfA-3g64A:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  53
LEU A  78
VAL A  83
ASP A 168
 None
None
NIL  A   1 (-4.9A)
NIL  A   1 (-4.6A)
 0.25A 3rgfA-3gp0A:
8.5		 3rgfA-3gp0A:
30.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs9 PROTEIN GP18

(Listeria
monocytogenes) 		PF06605
(Prophage_tail) 		4 LEU A  18
VAL A  61
VAL A  42
ASP A  56
 None
None
MLY  A  41 ( 3.0A)
None
 0.93A 3rgfA-3gs9A:
undetectable		 3rgfA-3gs9A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05193
(Peptidase_M16_C) 		4 LEU A  40
VAL A 197
VAL A 217
LEU A 227
 None
 0.95A 3rgfA-3gwbA:
undetectable		 3rgfA-3gwbA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdj PROBABLE ORNITHINE
CYCLODEAMINASE

(Bordetella
pertussis) 		PF02423
(OCD_Mu_crystall) 		4 LEU A 113
VAL A 279
VAL A 264
LEU A 224
 None
None
CL  A 311 ( 3.7A)
None
 0.94A 3rgfA-3hdjA:
undetectable		 3rgfA-3hdjA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)

(Rhodospirillum
rubrum) 		PF00072
(Response_reg) 		4 LEU A  49
VAL A  84
VAL A  11
LEU A 113
 None
 0.87A 3rgfA-3hebA:
undetectable		 3rgfA-3hebA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj6 FRUCTOKINASE

(Halothermothrix
orenii) 		PF00294
(PfkB) 		4 LEU A  86
VAL A  32
LEU A  27
ASP A 129
 None
 0.85A 3rgfA-3hj6A:
undetectable		 3rgfA-3hj6A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'

(Sulfolobus
solfataricus) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A 411
VAL A 339
VAL A 466
LEU A 441
 None
 0.75A 3rgfA-3hkzA:
undetectable		 3rgfA-3hkzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'

(Sulfolobus
solfataricus) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A 509
VAL A 551
LEU A 612
MET A 628
 None
 0.77A 3rgfA-3hkzA:
undetectable		 3rgfA-3hkzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 159
VAL A 155
VAL A 182
LEU A 150
ASP A 189
 None
 1.41A 3rgfA-3hmjA:
undetectable		 3rgfA-3hmjA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ioq CMS1MS2

(Vasconcellea
cundinamarcensis) 		PF00112
(Peptidase_C1) 		4 LEU A 121
VAL A 202
VAL A 130
ASP A 205
 None
None
None
SO4  A 407 (-3.3A)
 0.95A 3rgfA-3ioqA:
undetectable		 3rgfA-3ioqA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN F
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		4 LEU I  12
VAL I  37
VAL I  73
LEU G  30
 None
 0.97A 3rgfA-3jb9I:
undetectable		 3rgfA-3jb9I:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr2 HEXULOSE-6-PHOSPHATE
SYNTHASE SGBH

(Vibrio cholerae) 		PF00215
(OMPdecase) 		4 LEU A 128
LEU A 159
ASP A 121
MET A 119
 None
None
GOL  A1001 (-3.6A)
None
 0.94A 3rgfA-3jr2A:
undetectable		 3rgfA-3jr2A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF06094
(GGACT) 		4 LEU A  53
VAL A 118
VAL A  63
LEU A  78
 None
 0.96A 3rgfA-3jucA:
undetectable		 3rgfA-3jucA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32) 		5 LEU A  93
VAL A 109
VAL A 118
LEU A  89
ASP A 187
 None
 1.19A 3rgfA-3k1jA:
undetectable		 3rgfA-3k1jA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		4 LEU A 142
VAL A  73
LEU A  67
ASP A 156
 None
 0.95A 3rgfA-3kl8A:
4.1		 3rgfA-3kl8A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 LEU A 761
VAL A 827
VAL A 776
LEU A 832
 None
 0.86A 3rgfA-3kulA:
8.1		 3rgfA-3kulA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 213
VAL A 260
LEU A 252
ASP A 240
 None
None
None
MG  A 357 ( 3.3A)
 0.63A 3rgfA-3kumA:
undetectable		 3rgfA-3kumA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 252
VAL A 258
LEU A 213
ASP A 240
 None
None
None
MG  A 357 ( 3.3A)
 0.80A 3rgfA-3kumA:
undetectable		 3rgfA-3kumA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l86 ACETYLGLUTAMATE
KINASE

(Streptococcus
mutans) 		PF00696
(AA_kinase) 		4 LEU A 162
VAL A  38
VAL A 107
LEU A  85
 None
 0.96A 3rgfA-3l86A:
undetectable		 3rgfA-3l86A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld9 THYMIDYLATE KINASE

(Ehrlichia
chaffeensis) 		PF02223
(Thymidylate_kin) 		4 LEU A  83
VAL A  89
VAL A 123
LEU A  20
 None
 0.94A 3rgfA-3ld9A:
undetectable		 3rgfA-3ld9A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldh LACTATE
DEHYDROGENASE

(Squalus
acanthias) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A  45
LEU A  51
ASP A  36
MET A  34
 None
 0.80A 3rgfA-3ldhA:
undetectable		 3rgfA-3ldhA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 VAL A 271
VAL A 187
LEU A 291
ASP A 230
 None
PEG  A 645 ( 4.2A)
None
None
 0.89A 3rgfA-3lk6A:
undetectable		 3rgfA-3lk6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzx FERREDOXIN--NADP
REDUCTASE 2

(Bacillus
subtilis) 		PF07992
(Pyr_redox_2) 		4 LEU A 173
VAL A 157
VAL A 146
LEU A 237
 None
 0.77A 3rgfA-3lzxA:
undetectable		 3rgfA-3lzxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbr GLUTAMINE
CYCLOTRANSFERASE

(Xanthomonas
campestris) 		PF05096
(Glu_cyclase_2) 		4 LEU X 173
VAL X 187
VAL X 163
LEU X 209
 None
 0.86A 3rgfA-3mbrX:
undetectable		 3rgfA-3mbrX:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nom GLUTAMINE
CYCLOTRANSFERASE

(Zymomonas
mobilis) 		PF05096
(Glu_cyclase_2) 		4 LEU A 174
VAL A 188
VAL A 164
LEU A 210
 None
 0.92A 3rgfA-3nomA:
undetectable		 3rgfA-3nomA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqp PUTATIVE
ISOCHORISMATASE

(Paraburkholderia
xenovorans) 		PF00857
(Isochorismatase) 		4 VAL A  18
VAL A  76
LEU A  22
MET A 117
 None
 0.74A 3rgfA-3oqpA:
undetectable		 3rgfA-3oqpA:
18.96