SIMILAR PATTERNS OF AMINO ACIDS FOR 3RGF_A_BAXA465

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 588
ALA A 606
PHE A 654
TYR A 656
LEU A 715
HIS A 722
ALA A 741
 None
 0.76A 3rgfA-1lufA:
21.4		 3rgfA-1lufA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 VAL A 219
ALA A 230
GLU A 245
TYR A 282
LEU A 316
HIS A 331
ALA A 350
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
None
None
PY1  A 700 ( 4.2A)
 0.85A 3rgfA-1py5A:
16.2		 3rgfA-1py5A:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 VAL A 172
ALA A 185
GLU A 202
LEU A 206
PHE A 246
HIS A 292
ALA A 549
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
None
None
None
None
 0.57A 3rgfA-1q8yA:
8.6		 3rgfA-1q8yA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 642
GLU A 661
PHE A 691
TYR A 693
LEU A 802
HIS A 809
 None
 0.82A 3rgfA-1rjbA:
20.3		 3rgfA-1rjbA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 603
ALA A 621
GLU A 640
LEU A 644
TYR A 672
LEU A 783
HIS A 790
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 ( 4.0A)
None
STI  A   3 (-4.5A)
 0.85A 3rgfA-1t46A:
8.3		 3rgfA-1t46A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 VAL A  42
ALA A  55
GLU A  76
LEU A  80
ILE A  89
TYR A 107
LEU A 142
HIS A 149
 None
 0.72A 3rgfA-1u5qA:
23.1		 3rgfA-1u5qA:
24.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  26
ALA A  39
ILE A  75
PHE A  91
LEU A 128
HIS A 135
ALA A 154
 ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
None
None
None
None
None
 0.82A 3rgfA-1ua2A:
9.0		 3rgfA-1ua2A:
35.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  26
ALA A  39
LEU A  66
ILE A  75
PHE A  91
LEU A 128
ALA A 154
 ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
None
None
None
None
None
 0.72A 3rgfA-1ua2A:
9.0		 3rgfA-1ua2A:
35.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
LEU A 130
HIS A 137
 None
 0.67A 3rgfA-1zwsA:
22.5		 3rgfA-1zwsA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
LEU A 130
HIS A 137
 None
GOL  A3001 (-3.5A)
None
None
GOL  A3001 (-4.8A)
None
None
 0.56A 3rgfA-2a2aA:
7.4		 3rgfA-2a2aA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  98
ALA A 111
GLU A 129
LEU A 133
PHE A 159
LEU A 196
HIS A 203
 None
 0.81A 3rgfA-2ac5A:
20.2		 3rgfA-2ac5A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 170
ALA A 184
GLU A 201
LEU A 205
PHE A 236
LEU A 274
HIS A 281
ALA A 319
 None
 0.65A 3rgfA-2eu9A:
7.1		 3rgfA-2eu9A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 VAL A  42
ALA A  55
GLU A  76
ILE A  89
TYR A 107
LEU A 142
HIS A 149
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
None
STU  A 400 ( 4.5A)
STU  A 400 (-4.5A)
None
None
 0.72A 3rgfA-2gcdA:
8.1		 3rgfA-2gcdA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 VAL A  42
ALA A  55
GLU A  76
LEU A  80
TYR A 107
LEU A 142
HIS A 149
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
None
None
STU  A 400 (-4.5A)
None
None
 0.65A 3rgfA-2gcdA:
8.1		 3rgfA-2gcdA:
24.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  18
ALA A  31
GLU A  51
LEU A  55
PHE A  80
HIS A 125
ALA A 144
 None
 0.65A 3rgfA-2jgzA:
12.0		 3rgfA-2jgzA:
33.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 838
ALA A 853
LEU A 876
ILE A 886
TYR A 904
ALA A 905
LEU A 955
HIS A 962
ALA A 981
 MR9  A 301 (-4.6A)
MR9  A 301 (-3.5A)
MR9  A 301 ( 4.5A)
MR9  A 301 (-4.0A)
MR9  A 301 (-3.8A)
MR9  A 301 (-3.6A)
MR9  A 301 (-4.4A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
 0.90A 3rgfA-2p4iA:
18.9		 3rgfA-2p4iA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		8 VAL A  33
ALA A  46
GLU A  73
LEU A  77
ILE A  87
PHE A 103
LEU A 140
HIS A 147
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
None
None
None
None
 0.78A 3rgfA-2phkA:
23.1		 3rgfA-2phkA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 515
GLU A 534
ILE A 548
TYR A 566
ALA A 567
LEU A 617
HIS A 624
ALA A 643
 None
 1.07A 3rgfA-2psqA:
21.0		 3rgfA-2psqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 495
ALA A 515
GLU A 534
ILE A 548
ALA A 567
LEU A 617
HIS A 624
ALA A 643
 None
 0.86A 3rgfA-2psqA:
21.0		 3rgfA-2psqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 689
ALA A 705
GLU A 724
ILE A 737
TYR A 755
LEU A 791
HIS A 798
 None
 1.14A 3rgfA-2r2pA:
17.2		 3rgfA-2r2pA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  85
ALA A  98
GLU A 119
LEU A 123
TYR A 150
HIS A 193
ALA A 212
 BI8  A1417 ( 4.7A)
BI8  A1417 ( 3.8A)
BI8  A1417 ( 4.9A)
None
BI8  A1417 (-4.8A)
None
BI8  A1417 ( 4.1A)
 0.84A 3rgfA-2vd5A:
21.2		 3rgfA-2vd5A:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
LEU A 130
HIS A 137
 ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 ( 4.8A)
None
ADP  A1303 ( 4.2A)
None
None
 0.69A 3rgfA-2w4kA:
5.0		 3rgfA-2w4kA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  34
ALA A  47
GLU A  66
LEU A  70
TYR A  97
LEU A 131
HIS A 138
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
None
None
J60  A1294 ( 4.2A)
 0.86A 3rgfA-2xikA:
18.4		 3rgfA-2xikA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  38
ALA A  51
GLU A  77
LEU A  81
ILE A  91
PHE A 107
LEU A 144
HIS A 151
 None
B49  A1294 (-3.2A)
None
None
B49  A1294 ( 4.6A)
B49  A1294 (-4.0A)
None
None
 0.76A 3rgfA-2y7jA:
24.0		 3rgfA-2y7jA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
LEU A 130
HIS A 137
 AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
None
None
AMP  A1302 ( 3.8A)
None
None
 0.61A 3rgfA-2yabA:
17.8		 3rgfA-2yabA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 495
ALA A 515
ILE A 548
TYR A 566
ALA A 567
LEU A 617
HIS A 624
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
None
None
None
 0.82A 3rgfA-3b2tA:
17.3		 3rgfA-3b2tA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
LEU A 130
HIS A 137
 4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
GOL  A 503 (-2.8A)
None
4RB  A 401 ( 4.3A)
None
None
 0.58A 3rgfA-3bqrA:
21.8		 3rgfA-3bqrA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 512
GLU A 531
ILE A 545
TYR A 563
ALA A 564
LEU A 614
HIS A 621
ALA A 640
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.0A)
None
C4F  A   1 (-3.5A)
None
None
C4F  A   1 (-3.6A)
 1.05A 3rgfA-3c4fA:
21.1		 3rgfA-3c4fA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 492
ALA A 512
GLU A 531
ILE A 545
ALA A 564
LEU A 614
HIS A 621
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.0A)
C4F  A   1 (-3.5A)
None
None
C4F  A   1 (-3.6A)
 0.81A 3rgfA-3c4fA:
21.1		 3rgfA-3c4fA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  40
ALA A  53
GLU A  73
LEU A  77
ILE A  86
LEU A 142
HIS A 149
 35F  A   1 ( 4.8A)
35F  A   1 (-3.6A)
None
None
None
None
None
 0.76A 3rgfA-3e7oA:
10.1		 3rgfA-3e7oA:
28.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  38
ALA A  51
GLU A  71
LEU A  75
ILE A  84
HIS A 148
 NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-4.4A)
NIL  A   1 (-4.3A)
 0.51A 3rgfA-3gp0A:
10.0		 3rgfA-3gp0A:
30.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 841
ALA A 859
GLU A 878
LEU A 882
TYR A 911
LEU A1013
HIS A1020
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.9A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
 0.78A 3rgfA-3hngA:
7.8		 3rgfA-3hngA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 VAL A 689
ALA A 700
GLU A 715
LEU A 719
ILE A 729
LEU A 788
HIS A 795
 ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
None
None
None
None
None
 0.63A 3rgfA-3lj0A:
8.0		 3rgfA-3lj0A:
26.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 VAL A 566
ALA A 579
GLU A 596
LEU A 600
PHE A 630
LEU A 668
HIS A 675
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 ( 4.4A)
None
None
None
None
 0.77A 3rgfA-3lltA:
11.3		 3rgfA-3lltA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 VAL A 566
ALA A 579
GLU A 596
LEU A 600
PHE A 630
LEU A 673
HIS A 675
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 ( 4.4A)
None
None
None
None
 1.19A 3rgfA-3lltA:
11.3		 3rgfA-3lltA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A  47
ALA A  60
GLU A  80
LEU A  84
ILE A  94
TYR A 112
ALA A 113
LEU A 149
HIS A 156
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
None
 0.90A 3rgfA-3lm5A:
18.4		 3rgfA-3lm5A:
25.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  33
ALA A  46
GLU A  66
LEU A  70
PHE A 103
HIS A 147
ALA A 166
 None
 0.59A 3rgfA-3mi9A:
11.4		 3rgfA-3mi9A:
32.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 VAL A  69
ALA A  82
LEU A 107
ILE A 116
TYR A 134
ALA A 135
ALA A 194
 None
 0.91A 3rgfA-3mn3A:
5.7		 3rgfA-3mn3A:
24.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		7 VAL A  42
ALA A  55
GLU A  75
LEU A  79
ILE A  88
ALA A 112
HIS A 152
 None
GOL  A 434 ( 4.1A)
GOL  A 433 ( 4.8A)
None
None
GOL  A 434 (-3.9A)
None
 1.01A 3rgfA-3n9xA:
21.5		 3rgfA-3n9xA:
31.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 VAL A  44
ALA A  57
GLU A  77
LEU A  81
ILE A  90
ALA A 114
HIS A 154
 ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 ( 4.4A)
None
ANP  A 430 ( 4.5A)
ANP  A 430 (-3.9A)
None
 0.97A 3rgfA-3nieA:
6.7		 3rgfA-3nieA:
31.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 VAL A  37
ALA A  49
GLU A  69
LEU A  73
PHE A  98
ALA A 161
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
None
None
None
 0.53A 3rgfA-3nizA:
11.4		 3rgfA-3nizA:
37.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  96
ALA A 109
GLU A 130
TYR A 161
ALA A 162
LEU A 196
HIS A 203
 JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
JOZ  A 361 (-3.8A)
None
None
 0.80A 3rgfA-3nuuA:
23.7		 3rgfA-3nuuA:
26.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 ALA A  38
GLU A  58
LEU A  62
TYR A  92
LEU A 125
HIS A 132
ALA A 151
 None
 0.90A 3rgfA-3oz6A:
13.0		 3rgfA-3oz6A:
32.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 VAL A  25
ALA A  38
GLU A  58
LEU A  62
PHE A  90
TYR A  92
HIS A 132
ALA A 151
 None
 1.08A 3rgfA-3oz6A:
13.0		 3rgfA-3oz6A:
32.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		7 VAL A 356
ALA A 369
GLU A 390
LEU A 394
TYR A 422
LEU A 457
ALA A 483
 ANP  A 800 ( 4.7A)
ANP  A 800 (-3.6A)
None
None
ANP  A 800 (-4.2A)
None
ANP  A 800 ( 3.8A)
 0.88A 3rgfA-3pfqA:
18.5		 3rgfA-3pfqA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 VAL A  71
ALA A  84
GLU A 115
LEU A 119
ILE A 128
LEU A 181
HIS A 188
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
None
None
None
 0.63A 3rgfA-3q5iA:
21.8		 3rgfA-3q5iA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 492
ALA A 512
GLU A 531
ILE A 545
TYR A 563
ALA A 564
LEU A 614
HIS A 621
ALA A 640
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
None
None
07J  A   1 (-3.2A)
 0.91A 3rgfA-3tt0A:
20.7		 3rgfA-3tt0A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 552
ALA A 570
GLU A 588
LEU A 592
PHE A 617
LEU A 670
HIS A 677
 None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
0F4  A 902 (-4.7A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.8A)
0F4  A 902 (-4.1A)
 0.75A 3rgfA-3v5qA:
21.2		 3rgfA-3v5qA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  18
ALA A  31
GLU A  50
LEU A  54
PHE A  79
LEU A 116
HIS A 123
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 ( 4.8A)
None
38R  A 350 (-4.1A)
None
None
 0.74A 3rgfA-3zduA:
12.1		 3rgfA-3zduA:
28.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  18
ALA A  31
GLU A  51
LEU A  55
PHE A  80
TYR A  82
HIS A 124
 D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
None
None
D15  A 500 ( 4.3A)
D15  A 500 (-4.8A)
None
 0.72A 3rgfA-4aguA:
12.7		 3rgfA-4aguA:
31.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A  91
ALA A 104
GLU A 125
LEU A 129
TYR A 156
HIS A 199
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
None
EDO  A1420 (-4.9A)
None
None
 0.82A 3rgfA-4aw2A:
21.4		 3rgfA-4aw2A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  50
ALA A  63
GLU A  81
LEU A  85
LEU A 148
HIS A 155
ALA A 174
 XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
None
None
None
XZN  A1317 ( 4.3A)
 0.75A 3rgfA-4bc6A:
13.9		 3rgfA-4bc6A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		8 VAL A 254
ALA A 267
GLU A 288
LEU A 292
ILE A 302
TYR A 320
ALA A 321
HIS A 362
 None
 0.84A 3rgfA-4c0tA:
5.5		 3rgfA-4c0tA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 624
ALA A 653
GLU A 672
ILE A 685
TYR A 703
LEU A 757
HIS A 764
ALA A 783
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.0A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.7A)
 0.55A 3rgfA-4ckrA:
21.3		 3rgfA-4ckrA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 671
ALA A 684
GLU A 705
TYR A 739
ALA A 740
LEU A 773
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.70A 3rgfA-4crsA:
16.7		 3rgfA-4crsA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL B  38
ALA B  51
LEU B  74
TYR B 101
LEU B 135
HIS B 142
ALA B 161
 None
GOL  B1000 ( 4.3A)
None
GOL  B1000 (-4.0A)
None
None
None
 0.92A 3rgfA-4fzdB:
18.2		 3rgfA-4fzdB:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 164
ALA A 177
GLU A 198
LEU A 202
TYR A 229
ALA A 230
LEU A 264
 0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
GOL  A 503 (-3.6A)
None
0XZ  A 501 ( 4.9A)
0XZ  A 501 (-3.7A)
None
 0.87A 3rgfA-4gv1A:
22.7		 3rgfA-4gv1A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 836
ALA A 853
GLU A 871
LEU A 875
TYR A 904
LEU A 940
HIS A 947
ALA A 966
 19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
None
19S  A1201 (-4.7A)
None
None
19S  A1201 ( 4.1A)
 0.97A 3rgfA-4hviA:
16.1		 3rgfA-4hviA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 486
ALA A 506
GLU A 525
ILE A 539
TYR A 557
ALA A 558
LEU A 608
HIS A 615
ALA A 634
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 (-3.7A)
None
None
None
 1.03A 3rgfA-4k33A:
17.2		 3rgfA-4k33A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A  50
ALA A  61
GLU A  77
LEU A  81
TYR A 106
ALA A 107
LEU A 144
HIS A 154
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-4.1A)
1UL  A 501 (-3.6A)
None
None
 0.83A 3rgfA-4l52A:
4.3		 3rgfA-4l52A:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  41
ALA A  54
GLU A  70
TYR A 101
LEU A 137
HIS A 144
ALA A 163
 GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
GOL  A 404 ( 4.9A)
None
None
GOL  A 403 ( 3.0A)
 0.93A 3rgfA-4lg4A:
23.6		 3rgfA-4lg4A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL B  38
ALA B  51
GLU B  70
LEU B  74
TYR B 101
LEU B 135
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 ( 4.7A)
None
None
 0.71A 3rgfA-4o27B:
19.5		 3rgfA-4o27B:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL B  38
ALA B  51
GLU B  70
TYR B 101
LEU B 135
HIS B 142
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
ADP  B 500 ( 4.7A)
None
None
None
 0.66A 3rgfA-4o27B:
19.5		 3rgfA-4o27B:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 394
ALA A 407
GLU A 428
LEU A 432
TYR A 460
LEU A 495
ALA A 521
 PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
None
PZW  A 801 ( 4.6A)
 0.75A 3rgfA-4q9zA:
3.7		 3rgfA-4q9zA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 642
GLU A 661
PHE A 691
TYR A 693
LEU A 802
HIS A 809
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.7A)
P30  A1001 (-4.1A)
None
P30  A1001 ( 4.3A)
 0.70A 3rgfA-4rt7A:
21.2		 3rgfA-4rt7A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 VAL A  22
ALA A  35
GLU A  52
TYR A  83
LEU A 120
HIS A 127
ALA A 146
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 ( 4.5A)
None
None
None
 1.03A 3rgfA-4ueuA:
21.5		 3rgfA-4ueuA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 138
ALA A 149
ILE A 184
ALA A 203
LEU A 251
HIS A 261
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
AGS  A1438 (-4.2A)
AGS  A1438 (-3.7A)
None
None
 0.54A 3rgfA-4uyaA:
20.7		 3rgfA-4uyaA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 481
ALA A 501
GLU A 520
ILE A 534
ALA A 553
LEU A 603
HIS A 610
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
None
None
40M  A1002 (-3.0A)
 0.80A 3rgfA-4xcuA:
16.7		 3rgfA-4xcuA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 642
GLU A 661
PHE A 691
TYR A 693
LEU A 802
HIS A 809
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.3A)
P30  A1001 ( 4.4A)
None
P30  A1001 (-4.4A)
 0.74A 3rgfA-4xufA:
20.9		 3rgfA-4xufA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 477
ALA A 488
GLU A 509
LEU A 513
ILE A 522
TYR A 541
LEU A 577
HIS A 586
ALA A 605
 None
4CV  A 801 (-3.5A)
None
None
4CV  A 801 ( 4.2A)
4CV  A 801 (-3.9A)
None
None
4CV  A 801 ( 3.9A)
 0.87A 3rgfA-4yffA:
14.5		 3rgfA-4yffA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 173
ALA A 186
GLU A 203
LEU A 207
PHE A 238
LEU A 276
HIS A 285
 4E1  A 505 (-4.5A)
4E1  A 505 (-3.5A)
None
None
4E1  A 505 (-4.2A)
None
None
 0.71A 3rgfA-4yljA:
9.1		 3rgfA-4yljA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 VAL A 586
ALA A 597
GLU A 612
LEU A 616
ILE A 626
LEU A 679
HIS A 686
 None
 0.76A 3rgfA-4z7gA:
19.1		 3rgfA-4z7gA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 492
ALA A 512
GLU A 531
ILE A 545
TYR A 563
ALA A 564
LEU A 614
HIS A 621
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
None
None
EDO  A1766 ( 4.4A)
 0.88A 3rgfA-5a46A:
20.9		 3rgfA-5a46A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  30
ALA A  44
LEU A  67
TYR A  94
LEU A 129
HIS A 136
ALA A 164
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 ( 3.4A)
None
None
None
 0.91A 3rgfA-5ci7A:
5.1		 3rgfA-5ci7A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  70
ALA A  83
GLU A 103
TYR A 134
ALA A 135
HIS A 176
ALA A 195
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
None
5RC  A4000 ( 3.9A)
 0.83A 3rgfA-5es1A:
6.0		 3rgfA-5es1A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 911
ALA A 928
GLU A 947
LEU A 951
ILE A 960
TYR A 980
LEU A1014
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
None
 1.03A 3rgfA-5f1zA:
15.8		 3rgfA-5f1zA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 738
ALA A 756
GLU A 775
LEU A 779
ILE A 788
LEU A 865
HIS A 872
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
None
None
None
 1.01A 3rgfA-5fm2A:
7.6		 3rgfA-5fm2A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 738
ALA A 756
GLU A 775
LEU A 779
ILE A 788
TYR A 806
LEU A 865
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
None
None
None
 0.78A 3rgfA-5fm2A:
7.6		 3rgfA-5fm2A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 738
ALA A 756
LEU A 779
ILE A 788
ALA A 807
LEU A 865
HIS A 872
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
None
PP1  A2012 ( 3.5A)
None
None
 0.68A 3rgfA-5fm2A:
7.6		 3rgfA-5fm2A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 738
ALA A 756
LEU A 779
ILE A 788
TYR A 806
ALA A 807
LEU A 865
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
None
None
PP1  A2012 ( 3.5A)
None
 0.86A 3rgfA-5fm2A:
7.6		 3rgfA-5fm2A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A  30
ALA A  43
ILE A  66
TYR A  84
ALA A  85
LEU A 121
HIS A 131
 032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-4.2A)
032  A 401 (-3.6A)
None
None
 0.94A 3rgfA-5hesA:
20.9		 3rgfA-5hesA:
25.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		10 VAL A  35
ALA A  50
GLU A  66
LEU A  70
ILE A  79
PHE A  97
TYR A  99
ALA A 100
LEU A 142
HIS A 149
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
FMT  A 404 ( 4.2A)
None
6A7  A 401 (-4.2A)
6A7  A 401 (-3.8A)
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
None
FMT  A 403 (-4.6A)
 0.70A 3rgfA-5idnA:
45.0		 3rgfA-5idnA:
91.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		10 VAL A  35
ALA A  50
LEU A  70
ILE A  79
PHE A  97
TYR A  99
ALA A 100
LEU A 142
HIS A 149
ALA A 172
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
None
6A7  A 401 (-4.2A)
6A7  A 401 (-3.8A)
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
None
FMT  A 403 (-4.6A)
6A7  A 401 ( 4.1A)
 0.53A 3rgfA-5idnA:
45.0		 3rgfA-5idnA:
91.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 VAL A  30
ALA A  43
LEU A  68
ILE A  77
TYR A  95
HIS A 137
ALA A 156
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
None
STU  A 601 (-3.5A)
 1.08A 3rgfA-5isoA:
5.6		 3rgfA-5isoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 163
ALA A 176
GLU A 193
LEU A 197
ILE A 212
PHE A 228
LEU A 266
HIS A 273
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.7A)
None
7A7  A 501 (-4.8A)
7A7  A 501 (-3.7A)
None
None
 0.79A 3rgfA-5lxdA:
11.9		 3rgfA-5lxdA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 106
ALA A 119
GLU A 136
LEU A 140
PHE A 177
LEU A 215
HIS A 223
ALA A 540
 W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
DMS  A 717 (-4.0A)
None
DMS  A 717 ( 3.9A)
None
None
DMS  A 717 ( 4.5A)
 0.64A 3rgfA-5myvA:
21.1		 3rgfA-5myvA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 8 VAL A  94
ALA A 107
GLU A 124
LEU A 128
PHE A 165
LEU A 203
HIS A 211
ALA A 496
 EMH  A 705 ( 4.4A)
EMH  A 705 (-3.6A)
None
None
EMH  A 705 (-3.6A)
None
None
EMH  A 705 ( 4.0A)
 0.65A 3rgfA-5xv7A:
8.5		 3rgfA-5xv7A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		8 VAL A  57
ALA A  70
GLU A  85
LEU A  89
ILE A  99
PHE A 117
TYR A 119
HIS A 158
 ATP  A 403 (-3.9A)
ATP  A 403 (-3.4A)
None
None
ATP  A 403 (-4.9A)
None
None
None
 0.72A 3rgfA-5xvuA:
8.8		 3rgfA-5xvuA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 7 VAL A 223
ALA A 236
GLU A 253
LEU A 257
ILE A 272
PHE A 288
LEU A 326
 HRM  A 601 ( 4.9A)
HRM  A 601 (-3.5A)
HRM  A 601 ( 4.6A)
None
HRM  A 601 ( 4.8A)
HRM  A 601 (-3.6A)
None
 0.59A 3rgfA-5y86A:
20.8		 3rgfA-5y86A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 7 VAL A 223
ALA A 236
LEU A 257
ILE A 272
PHE A 288
LEU A 326
HIS A 333
 HRM  A 601 ( 4.9A)
HRM  A 601 (-3.5A)
None
HRM  A 601 ( 4.8A)
HRM  A 601 (-3.6A)
None
None
 0.63A 3rgfA-5y86A:
20.8		 3rgfA-5y86A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 8 VAL A 741
ALA A 754
GLU A 774
LEU A 778
PHE A 813
TYR A 815
HIS A 857
ALA A 876
 None
CJM  A1102 (-3.1A)
None
None
CJM  A1102 ( 4.4A)
CJM  A1102 (-4.1A)
None
CJM  A1102 (-3.6A)
 0.60A 3rgfA-6b3eA:
10.9		 3rgfA-6b3eA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 VAL A 179
ALA A 192
LEU A 240
PHE A 267
LEU A 303
HIS A 310
ALA A 329
 BI9  A 501 ( 4.8A)
BI9  A 501 (-3.3A)
None
BI9  A 501 ( 4.2A)
None
None
NH4  A 506 ( 3.7A)
 0.84A 3rgfA-6bqlA:
5.7		 3rgfA-6bqlA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 VAL A  74
ALA A  87
GLU A 107
TYR A 138
ALA A 139
HIS A 180
ALA A 199
 None
 0.85A 3rgfA-6c9dA:
22.3		 3rgfA-6c9dA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 6 VAL A 142
ALA A 155
PHE A 230
LEU A 266
HIS A 273
ALA A 292
 H1N  A 501 (-4.4A)
H1N  A 501 (-3.4A)
H1N  A 501 (-3.7A)
None
None
H1N  A 501 ( 3.9A)
 0.56A 3rgfA-6ccfA:
7.7		 3rgfA-6ccfA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 8 VAL A 179
ALA A 192
GLU A 236
LEU A 240
PHE A 267
LEU A 303
HIS A 310
ALA A 329
 F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 ( 4.7A)
None
F6J  A 501 (-3.7A)
None
None
F6J  A 501 ( 4.0A)
 0.81A 3rgfA-6cmjA:
7.6		 3rgfA-6cmjA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 7 VAL A 701
ALA A 715
GLU A 732
LEU A 736
PHE A 767
LEU A 806
HIS A 813
 919  A1101 (-4.7A)
919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-3.8A)
None
919  A1101 (-4.2A)
 0.57A 3rgfA-6cnhA:
11.7		 3rgfA-6cnhA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 7 VAL A 738
ALA A 756
GLU A 775
LEU A 779
ILE A 788
TYR A 806
LEU A 865
 ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
None
ADN  A1104 ( 4.7A)
ADN  A1104 ( 4.1A)
None
 0.78A 3rgfA-6fekA:
21.1		 3rgfA-6fekA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 8 VAL A 738
ALA A 756
LEU A 779
ILE A 788
TYR A 806
ALA A 807
LEU A 865
HIS A 872
 ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.7A)
ADN  A1104 ( 4.1A)
ADN  A1104 (-3.6A)
None
None
 0.89A 3rgfA-6fekA:
21.1		 3rgfA-6fekA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 7 VAL A 177
ALA A 191
GLU A 208
LEU A 212
PHE A 243
LEU A 281
HIS A 288
 3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 ( 4.9A)
None
3NG  A 501 (-3.5A)
None
None
 0.62A 3rgfA-6fylA:
6.9		 3rgfA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 7 VAL A 175
ALA A 189
GLU A 206
LEU A 210
PHE A 241
LEU A 279
HIS A 286
 3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.7A)
None
3NG  A 501 (-3.5A)
None
None
 0.58A 3rgfA-6fyvA:
25.2		 3rgfA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0i D-AMINO ACID OXIDASE

(Rhodotorula
toruloides) 		PF01266
(DAO) 		4 LEU A1010
VAL A1175
VAL A1162
ASP A1170
 None
None
FAD  A1363 (-4.0A)
None
 0.86A 3rgfA-1c0iA:
0.0		 3rgfA-1c0iA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4x PROTEIN
(2-HYDROXY-6-OXO-6-P
HENYLHEXA-2,4-DIENOA
TE HYDROLASE)

(Rhodococcus
jostii) 		PF12697
(Abhydrolase_6) 		5 LEU A  33
VAL A 107
VAL A  60
LEU A 228
MET A 276
 None
 1.28A 3rgfA-1c4xA:
0.0		 3rgfA-1c4xA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		4 LEU A 325
VAL A  78
LEU A 356
ASP A 318
 None
None
None
ADN  A 375 ( 3.1A)
 0.77A 3rgfA-1dgmA:
0.0		 3rgfA-1dgmA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtp DIPHTHERIA TOXIN

(Corynephage
beta) 		PF02763
(Diphtheria_C) 		4 LEU A  92
VAL A 134
LEU A  88
ASP A 129
 None
 0.92A 3rgfA-1dtpA:
0.0		 3rgfA-1dtpA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N) 		4 LEU A 118
VAL A  12
VAL A 196
ASP A  43
 None
 0.85A 3rgfA-1fi4A:
0.0		 3rgfA-1fi4A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g68 BETA-LACTAMASE PSE-4

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		4 VAL A 261
LEU A 190
ASP A 233
MET A 211
 None
 0.92A 3rgfA-1g68A:
0.0		 3rgfA-1g68A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyq CELL DIVISION
INHIBITOR (MIND-1)

(Archaeoglobus
fulgidus) 		PF01656
(CbiA) 		4 LEU A  59
VAL A  83
VAL A 103
ASP A  70
 None
 0.80A 3rgfA-1hyqA:
0.0		 3rgfA-1hyqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		4 LEU A 611
VAL A 597
LEU A 407
ASP A 390
 None
 0.95A 3rgfA-1i6qA:
0.0		 3rgfA-1i6qA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 LEU A  46
VAL A  42
VAL A  61
LEU A 111
 None
 0.96A 3rgfA-1jqoA:
0.0		 3rgfA-1jqoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khi HEX1

(Neurospora
crassa) 		PF01287
(eIF-5a) 		4 LEU A 141
VAL A 131
VAL A 108
LEU A  74
 None
 0.90A 3rgfA-1khiA:
undetectable		 3rgfA-1khiA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		5 LEU A  20
VAL A  73
LEU A 240
ASP A  16
MET A  15
 None
 1.13A 3rgfA-1ktnA:
undetectable		 3rgfA-1ktnA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mab PROTEIN (F1-ATPASE
BETA CHAIN)

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 LEU B  69
VAL B  16
VAL B  38
LEU B 271
 None
 0.93A 3rgfA-1mabB:
undetectable		 3rgfA-1mabB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 LEU A 607
VAL A 808
LEU A1219
ASP A 832
 None
 0.92A 3rgfA-1n5xA:
undetectable		 3rgfA-1n5xA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvt SHIKIMATE
5'-DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 LEU A 191
VAL A 132
VAL A 215
LEU A 147
 None
 0.73A 3rgfA-1nvtA:
undetectable		 3rgfA-1nvtA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		4 LEU A  16
VAL A  26
VAL A  46
ASP A  12
 None
 0.93A 3rgfA-1o54A:
undetectable		 3rgfA-1o54A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT

(Acidaminococcus
fermentans) 		PF01039
(Carboxyl_trans) 		4 LYS A 393
VAL A 409
LEU A 462
MET A 346
 None
 0.95A 3rgfA-1pixA:
undetectable		 3rgfA-1pixA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 LEU A 513
VAL A 497
VAL A 486
LEU A 615
 None
 0.86A 3rgfA-1ps9A:
undetectable		 3rgfA-1ps9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 818
VAL A 675
LEU A 668
ASP A 829
 None
 0.82A 3rgfA-1rjbA:
20.3		 3rgfA-1rjbA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rm8 MATRIX
METALLOPROTEINASE-16

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 LEU A 278
VAL A 162
VAL A 245
ASP A 157
 None
 0.94A 3rgfA-1rm8A:
undetectable		 3rgfA-1rm8A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 391
LEU A 413
VAL A 478
LEU A 489
 None
 0.76A 3rgfA-1snxA:
20.8		 3rgfA-1snxA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2f L-LACTATE
DEHYDROGENASE B
CHAIN

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 330
VAL A 146
VAL A 110
ASP A 141
 None
 0.96A 3rgfA-1t2fA:
undetectable		 3rgfA-1t2fA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 799
VAL A 654
LEU A 647
ASP A 810
 STI  A   3 (-4.4A)
STI  A   3 (-4.3A)
None
STI  A   3 (-3.9A)
 0.64A 3rgfA-1t46A:
8.3		 3rgfA-1t46A:
25.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 LYS A  32
LEU A  57
VAL A 121
LEU A 132
 None
 0.67A 3rgfA-1v0bA:
24.9		 3rgfA-1v0bA:
33.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0h 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T) 		4 VAL A 157
LEU A 227
ASP A 134
MET A 235
 None
None
MG  A1000 (-2.0A)
None
 0.96A 3rgfA-1w0hA:
undetectable		 3rgfA-1w0hA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE

(Escherichia
coli) 		PF00171
(Aldedh) 		4 LEU A 296
VAL A 255
VAL A 265
ASP A 260
 None
 0.94A 3rgfA-1wnbA:
undetectable		 3rgfA-1wnbA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 LEU A 137
VAL A 252
VAL A 159
LEU A 123
 None
 0.84A 3rgfA-1wytA:
undetectable		 3rgfA-1wytA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		4 LEU A 170
VAL A 181
VAL A 103
MET A 158
 None
 0.92A 3rgfA-1xviA:
undetectable		 3rgfA-1xviA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqb UBIQUILIN 3

(Homo sapiens) 		PF00240
(ubiquitin) 		4 LEU A  46
VAL A  37
VAL A  87
ASP A  34
 None
 0.92A 3rgfA-1yqbA:
undetectable		 3rgfA-1yqbA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		4 VAL A 261
LEU A 190
ASP A 233
MET A 211
 None
 0.93A 3rgfA-1zg4A:
undetectable		 3rgfA-1zg4A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Homo sapiens) 		PF01424
(R3H)
PF04857
(CAF1) 		4 VAL A 284
VAL A 293
ASP A 324
MET A 328
 None
 0.87A 3rgfA-2a1rA:
undetectable		 3rgfA-2a1rA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 113
VAL A 142
LEU A 212
ASP A 226
 None
 0.92A 3rgfA-2ac5A:
20.2		 3rgfA-2ac5A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1

(Saccharomyces
cerevisiae) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		4 VAL A 395
VAL A 368
LEU A 470
MET A 437
 None
 0.91A 3rgfA-2bmbA:
undetectable		 3rgfA-2bmbA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 LEU A1334
VAL A1358
LEU A1326
ASP A1128
 None
 0.85A 3rgfA-2bruA:
undetectable		 3rgfA-2bruA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3d 2-OXOPROPYL-COM
REDUCTASE

(Xanthobacter
autotrophicus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 325
VAL A 348
VAL A 160
LEU A 341
 None
 0.97A 3rgfA-2c3dA:
undetectable		 3rgfA-2c3dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chr CHLOROMUCONATE
CYCLOISOMERASE

(Cupriavidus
necator) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 218
VAL A 265
LEU A 257
ASP A 245
 None
None
None
MN  A 400 ( 3.1A)
 0.88A 3rgfA-2chrA:
undetectable		 3rgfA-2chrA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		4 LEU A 163
VAL A 135
VAL A 171
ASP A 140
 None
 0.96A 3rgfA-2d0oA:
undetectable		 3rgfA-2d0oA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 LYS A 484
LEU A 425
VAL A 419
ASP A 395
 None
 0.91A 3rgfA-2d3tA:
undetectable		 3rgfA-2d3tA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9f FK506-BINDING
PROTEIN 8 VARIANT

(Homo sapiens) 		PF00254
(FKBP_C) 		4 LEU A  73
VAL A  88
VAL A  42
LEU A  11
 None
 0.87A 3rgfA-2d9fA:
undetectable		 3rgfA-2d9fA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi9 OUTER MEMBRANE
PROTEIN

(Bartonella
henselae) 		PF04430
(DUF498) 		4 LEU A 113
VAL A  71
LEU A  91
ASP A  99
 None
 0.87A 3rgfA-2fi9A:
undetectable		 3rgfA-2fi9A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 LEU A 546
VAL A 728
LEU A 370
ASP A 522
 None
 0.94A 3rgfA-2fuqA:
undetectable		 3rgfA-2fuqA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 LEU A  71
VAL A  89
VAL A 153
ASP A 121
 None
 0.81A 3rgfA-2hdiA:
undetectable		 3rgfA-2hdiA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 LEU A  94
VAL A 482
LEU A 568
ASP A 556
 None
 0.70A 3rgfA-2hdiA:
undetectable		 3rgfA-2hdiA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 371
VAL A 301
LEU A 295
ASP A 382
 1BM  A 499 (-4.4A)
None
None
1BM  A 499 (-4.4A)
 0.86A 3rgfA-2hk5A:
15.9		 3rgfA-2hk5A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR

(Escherichia
coli) 		PF03466
(LysR_substrate) 		4 LEU A 240
VAL A 168
VAL A 227
LEU A 175
 None
 0.77A 3rgfA-2hxrA:
undetectable		 3rgfA-2hxrA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A  29
VAL A  12
VAL A 330
LEU A  78
 None
 0.82A 3rgfA-2i3aA:
undetectable		 3rgfA-2i3aA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihm DNA POLYMERASE MU

(Mus musculus) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 LEU A 298
VAL A 417
LEU A 347
ASP A 420
 None
None
None
NA  A 902 (-3.8A)
 0.85A 3rgfA-2ihmA:
undetectable		 3rgfA-2ihmA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw0 CHITIN DEACETYLASE

(Colletotrichum
lindemuthianum) 		PF01522
(Polysacc_deac_1) 		4 LYS A  29
LEU A  43
VAL A 232
LEU A 100
 None
 0.92A 3rgfA-2iw0A:
undetectable		 3rgfA-2iw0A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE

(Mus musculus) 		PF02434
(Fringe) 		4 LEU A 155
VAL A 272
VAL A 167
LEU A 263
 None
 0.96A 3rgfA-2j0aA:
undetectable		 3rgfA-2j0aA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j9l CHLORIDE CHANNEL
PROTEIN 5

(Homo sapiens) 		PF00571
(CBS) 		4 LEU A 640
VAL A 635
VAL A 608
LEU A 685
 None
 0.91A 3rgfA-2j9lA:
undetectable		 3rgfA-2j9lA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh3 RIBOSOMAL PROTEIN
S2-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF01903
(CbiX) 		4 LEU A  57
VAL A  60
VAL A  67
ASP A  64
 None
 0.86A 3rgfA-2jh3A:
undetectable		 3rgfA-2jh3A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00342
(PGI) 		4 LYS A 259
LEU A 408
VAL A 550
LEU A 151
 None
 0.95A 3rgfA-2o2cA:
undetectable		 3rgfA-2o2cA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 371
VAL A 301
LEU A 295
ASP A 382
 1N8  A 501 ( 4.3A)
None
1N8  A 501 ( 3.9A)
1N8  A 501 ( 3.3A)
 0.62A 3rgfA-2og8A:
21.7		 3rgfA-2og8A:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 273
LEU A 295
LEU A 371
ASP A 382
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.9A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
 0.96A 3rgfA-2og8A:
21.7		 3rgfA-2og8A:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyr UPF0341 PROTEIN YHIQ

(Shigella
flexneri) 		PF04445
(SAM_MT) 		4 VAL A  92
VAL A 216
LEU A 147
ASP A 102
 None
None
None
SAH  A 301 (-3.4A)
 0.93A 3rgfA-2oyrA:
undetectable		 3rgfA-2oyrA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbj OB TCR

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU D 137
VAL D  33
VAL D 103
LEU D 243
 None
 0.92A 3rgfA-2wbjD:
undetectable		 3rgfA-2wbjD:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS C  78
LEU C 105
VAL C 110
LEU C 183
 ANP  C   2 (-3.6A)
None
None
None
 0.60A 3rgfA-2wtkC:
8.6		 3rgfA-2wtkC:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyo GLUTATHIONE
SYNTHETASE

(Trypanosoma
brucei) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 VAL A 320
VAL A 277
LEU A 113
ASP A 213
 None
 0.97A 3rgfA-2wyoA:
undetectable		 3rgfA-2wyoA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		4 LEU A 184
VAL A 215
VAL A 196
LEU A 305
 None
 0.95A 3rgfA-2x4gA:
undetectable		 3rgfA-2x4gA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN

(Streptomyces
coelicolor) 		PF01497
(Peripla_BP_2) 		4 LEU A 213
VAL A 254
LEU A 180
ASP A 245
 None
 0.86A 3rgfA-2x4lA:
undetectable		 3rgfA-2x4lA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis) 		PF01593
(Amino_oxidase) 		4 LEU A  68
VAL A  61
VAL A 217
LEU A 206
 None
 0.83A 3rgfA-2yg6A:
undetectable		 3rgfA-2yg6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 220
VAL A 227
VAL A 264
LEU A 298
 None
 0.96A 3rgfA-2yxzA:
undetectable		 3rgfA-2yxzA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		4 LEU A 544
VAL A 549
VAL A 578
ASP A 553
 None
 0.67A 3rgfA-3a5iA:
undetectable		 3rgfA-3a5iA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 LEU A 146
VAL A 253
VAL A 115
ASP A  76
 None
 0.97A 3rgfA-3actA:
undetectable		 3rgfA-3actA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwn L-TRYPTOPHAN
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF04864
(Alliinase_C) 		5 LEU A 330
VAL A 364
VAL A 298
LEU A 367
MET A 287
 None
 1.44A 3rgfA-3bwnA:
undetectable		 3rgfA-3bwnA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8u FRUCTOKINASE

(Ruegeria sp.
TM1040) 		no annotation 4 LEU A  45
VAL A 125
VAL A  10
LEU A  94
 None
 0.87A 3rgfA-3c8uA:
undetectable		 3rgfA-3c8uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq9 UNCHARACTERIZED
PROTEIN LP_1622

(Lactobacillus
plantarum) 		PF04263
(TPK_catalytic) 		4 LEU A  66
VAL A  47
LEU A  83
ASP A  50
 None
 0.93A 3rgfA-3cq9A:
undetectable		 3rgfA-3cq9A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF01063
(Aminotran_4) 		4 LEU A 238
VAL A 235
LEU A 109
ASP A 152
 None
 0.73A 3rgfA-3cswA:
undetectable		 3rgfA-3cswA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dj4 BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 LEU A 118
VAL A  40
VAL A 184
ASP A 114
 None
None
None
MG  A 496 ( 2.6A)
 0.95A 3rgfA-3dj4A:
undetectable		 3rgfA-3dj4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 LYS A 665
VAL A 694
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.5A)
None
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.52A 3rgfA-3dkoA:
undetectable		 3rgfA-3dkoA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egh SPINOPHILIN

(Rattus
norvegicus) 		PF00595
(PDZ) 		4 LEU C 557
VAL C 560
VAL C 568
LEU C 521
 None
 0.95A 3rgfA-3eghC:
undetectable		 3rgfA-3eghC:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7w PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Thermobifida
fusca) 		PF03881
(Fructosamin_kin) 		4 LEU A 230
VAL A 199
LEU A 246
ASP A 221
 None
 0.85A 3rgfA-3f7wA:
5.5		 3rgfA-3f7wA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7w PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Thermobifida
fusca) 		PF03881
(Fructosamin_kin) 		4 LEU A 230
VAL A 236
VAL A 199
ASP A 221
 None
 0.90A 3rgfA-3f7wA:
5.5		 3rgfA-3f7wA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE

(Pseudomonas
protegens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 224
VAL A 271
LEU A 263
ASP A 251
 None
None
None
MG  A1001 ( 3.3A)
 0.88A 3rgfA-3fj4A:
undetectable		 3rgfA-3fj4A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g64 PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
coelicolor) 		PF00378
(ECH_1) 		4 LEU A  54
VAL A  60
VAL A  19
LEU A 214
 None
 0.93A 3rgfA-3g64A:
undetectable		 3rgfA-3g64A:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  53
LEU A  78
VAL A  83
ASP A 168
 None
None
NIL  A   1 (-4.9A)
NIL  A   1 (-4.6A)
 0.25A 3rgfA-3gp0A:
8.5		 3rgfA-3gp0A:
30.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs9 PROTEIN GP18

(Listeria
monocytogenes) 		PF06605
(Prophage_tail) 		4 LEU A  18
VAL A  61
VAL A  42
ASP A  56
 None
None
MLY  A  41 ( 3.0A)
None
 0.93A 3rgfA-3gs9A:
undetectable		 3rgfA-3gs9A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05193
(Peptidase_M16_C) 		4 LEU A  40
VAL A 197
VAL A 217
LEU A 227
 None
 0.95A 3rgfA-3gwbA:
undetectable		 3rgfA-3gwbA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdj PROBABLE ORNITHINE
CYCLODEAMINASE

(Bordetella
pertussis) 		PF02423
(OCD_Mu_crystall) 		4 LEU A 113
VAL A 279
VAL A 264
LEU A 224
 None
None
CL  A 311 ( 3.7A)
None
 0.94A 3rgfA-3hdjA:
undetectable		 3rgfA-3hdjA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)

(Rhodospirillum
rubrum) 		PF00072
(Response_reg) 		4 LEU A  49
VAL A  84
VAL A  11
LEU A 113
 None
 0.87A 3rgfA-3hebA:
undetectable		 3rgfA-3hebA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj6 FRUCTOKINASE

(Halothermothrix
orenii) 		PF00294
(PfkB) 		4 LEU A  86
VAL A  32
LEU A  27
ASP A 129
 None
 0.85A 3rgfA-3hj6A:
undetectable		 3rgfA-3hj6A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'

(Sulfolobus
solfataricus) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A 411
VAL A 339
VAL A 466
LEU A 441
 None
 0.75A 3rgfA-3hkzA:
undetectable		 3rgfA-3hkzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'

(Sulfolobus
solfataricus) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A 509
VAL A 551
LEU A 612
MET A 628
 None
 0.77A 3rgfA-3hkzA:
undetectable		 3rgfA-3hkzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 159
VAL A 155
VAL A 182
LEU A 150
ASP A 189
 None
 1.41A 3rgfA-3hmjA:
undetectable		 3rgfA-3hmjA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ioq CMS1MS2

(Vasconcellea
cundinamarcensis) 		PF00112
(Peptidase_C1) 		4 LEU A 121
VAL A 202
VAL A 130
ASP A 205
 None
None
None
SO4  A 407 (-3.3A)
 0.95A 3rgfA-3ioqA:
undetectable		 3rgfA-3ioqA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN F
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		4 LEU I  12
VAL I  37
VAL I  73
LEU G  30
 None
 0.97A 3rgfA-3jb9I:
undetectable		 3rgfA-3jb9I:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr2 HEXULOSE-6-PHOSPHATE
SYNTHASE SGBH

(Vibrio cholerae) 		PF00215
(OMPdecase) 		4 LEU A 128
LEU A 159
ASP A 121
MET A 119
 None
None
GOL  A1001 (-3.6A)
None
 0.94A 3rgfA-3jr2A:
undetectable		 3rgfA-3jr2A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF06094
(GGACT) 		4 LEU A  53
VAL A 118
VAL A  63
LEU A  78
 None
 0.96A 3rgfA-3jucA:
undetectable		 3rgfA-3jucA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32) 		5 LEU A  93
VAL A 109
VAL A 118
LEU A  89
ASP A 187
 None
 1.19A 3rgfA-3k1jA:
undetectable		 3rgfA-3k1jA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		4 LEU A 142
VAL A  73
LEU A  67
ASP A 156
 None
 0.95A 3rgfA-3kl8A:
4.1		 3rgfA-3kl8A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 LEU A 761
VAL A 827
VAL A 776
LEU A 832
 None
 0.86A 3rgfA-3kulA:
8.1		 3rgfA-3kulA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 213
VAL A 260
LEU A 252
ASP A 240
 None
None
None
MG  A 357 ( 3.3A)
 0.63A 3rgfA-3kumA:
undetectable		 3rgfA-3kumA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 252
VAL A 258
LEU A 213
ASP A 240
 None
None
None
MG  A 357 ( 3.3A)
 0.80A 3rgfA-3kumA:
undetectable		 3rgfA-3kumA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l86 ACETYLGLUTAMATE
KINASE

(Streptococcus
mutans) 		PF00696
(AA_kinase) 		4 LEU A 162
VAL A  38
VAL A 107
LEU A  85
 None
 0.96A 3rgfA-3l86A:
undetectable		 3rgfA-3l86A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld9 THYMIDYLATE KINASE

(Ehrlichia
chaffeensis) 		PF02223
(Thymidylate_kin) 		4 LEU A  83
VAL A  89
VAL A 123
LEU A  20
 None
 0.94A 3rgfA-3ld9A:
undetectable		 3rgfA-3ld9A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldh LACTATE
DEHYDROGENASE

(Squalus
acanthias) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A  45
LEU A  51
ASP A  36
MET A  34
 None
 0.80A 3rgfA-3ldhA:
undetectable		 3rgfA-3ldhA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 VAL A 271
VAL A 187
LEU A 291
ASP A 230
 None
PEG  A 645 ( 4.2A)
None
None
 0.89A 3rgfA-3lk6A:
undetectable		 3rgfA-3lk6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzx FERREDOXIN--NADP
REDUCTASE 2

(Bacillus
subtilis) 		PF07992
(Pyr_redox_2) 		4 LEU A 173
VAL A 157
VAL A 146
LEU A 237
 None
 0.77A 3rgfA-3lzxA:
undetectable		 3rgfA-3lzxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbr GLUTAMINE
CYCLOTRANSFERASE

(Xanthomonas
campestris) 		PF05096
(Glu_cyclase_2) 		4 LEU X 173
VAL X 187
VAL X 163
LEU X 209
 None
 0.86A 3rgfA-3mbrX:
undetectable		 3rgfA-3mbrX:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nom GLUTAMINE
CYCLOTRANSFERASE

(Zymomonas
mobilis) 		PF05096
(Glu_cyclase_2) 		4 LEU A 174
VAL A 188
VAL A 164
LEU A 210
 None
 0.92A 3rgfA-3nomA:
undetectable		 3rgfA-3nomA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqp PUTATIVE
ISOCHORISMATASE

(Paraburkholderia
xenovorans) 		PF00857
(Isochorismatase) 		4 VAL A  18
VAL A  76
LEU A  22
MET A 117
 None
 0.74A 3rgfA-3oqpA:
undetectable		 3rgfA-3oqpA:
18.96