SIMILAR PATTERNS OF AMINO ACIDS FOR 3RF4_C_FUNC203

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a87 COLICIN N

(Escherichia
coli) 		PF01024
(Colicin) 		5 ILE A 370
SER A 364
ILE A 363
VAL A 225
VAL A 203
 None
 1.24A 3rf4B-1a87A:
undetectable
3rf4C-1a87A:
undetectable		 3rf4B-1a87A:
15.61
3rf4C-1a87A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c25 CDC25A

(Homo sapiens) 		PF00581
(Rhodanese) 		5 ILE A 395
PRO A 361
SER A 360
ILE A 359
VAL A 427
 None
 1.33A 3rf4B-1c25A:
0.7
3rf4C-1c25A:
0.7		 3rf4B-1c25A:
18.01
3rf4C-1c25A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		5 ILE A  36
SER A  65
ILE A  62
VAL A  99
VAL A  57
 None
 1.37A 3rf4B-1cbfA:
0.0
3rf4C-1cbfA:
0.0		 3rf4B-1cbfA:
18.15
3rf4C-1cbfA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqj SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ILE A   2
SER A 185
ILE A 119
VAL A 175
VAL A 126
 None
 1.26A 3rf4B-1cqjA:
undetectable
3rf4C-1cqjA:
0.0		 3rf4B-1cqjA:
14.54
3rf4C-1cqjA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ILE A 307
PRO A 299
SER A 524
VAL A 535
VAL A 536
 None
 1.11A 3rf4B-1gpeA:
0.0
3rf4C-1gpeA:
undetectable		 3rf4B-1gpeA:
10.75
3rf4C-1gpeA:
10.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfo MIGRATION INHIBITORY
FACTOR

(Trichinella
spiralis) 		PF01187
(MIF) 		5 PRO A   1
LYS A  32
SER A  63
ILE A  64
VAL A 106
 None
 0.25A 3rf4B-1hfoA:
19.6
3rf4C-1hfoA:
19.6		 3rf4B-1hfoA:
30.09
3rf4C-1hfoA:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 SER A 494
ILE A 493
VAL A 479
PHE A 610
VAL A 459
 None
 1.23A 3rf4B-1k72A:
0.0
3rf4C-1k72A:
0.0		 3rf4B-1k72A:
11.41
3rf4C-1k72A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		5 ILE A 124
SER A 151
VAL A 122
PHE A 165
VAL A 163
 None
 1.25A 3rf4B-1l1lA:
0.2
3rf4C-1l1lA:
0.2		 3rf4B-1l1lA:
11.61
3rf4C-1l1lA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lo9 4-HYDROXYBENZOYL-COA
THIOESTERASE

(Pseudomonas sp.
CBS3) 		no annotation 5 HIS A  28
SER A  97
VAL A 110
PHE A  68
VAL A  69
 None
 1.24A 3rf4B-1lo9A:
0.0
3rf4C-1lo9A:
undetectable		 3rf4B-1lo9A:
22.07
3rf4C-1lo9A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 ILE A 210
MET A 140
ILE A 231
VAL A 208
VAL A 107
 None
 1.34A 3rf4B-1mroA:
2.3
3rf4C-1mroA:
undetectable		 3rf4B-1mroA:
10.55
3rf4C-1mroA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9j ALDEHYDE
DEHYDROGENASE,
CYTOSOLIC 1

(Elephantulus
edwardii) 		PF00171
(Aldedh) 		5 ILE A 165
SER A 234
VAL A 241
PHE A 243
VAL A 265
 NAD  A1501 (-4.5A)
None
None
NAD  A1501 (-4.5A)
None
 1.06A 3rf4B-1o9jA:
undetectable
3rf4C-1o9jA:
undetectable		 3rf4B-1o9jA:
15.80
3rf4C-1o9jA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1om9 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1

(Homo sapiens) 		PF02883
(Alpha_adaptinC2) 		5 PRO A 503
SER A 506
ILE A 507
VAL A 542
VAL A 544
 None
 1.34A 3rf4B-1om9A:
undetectable
3rf4C-1om9A:
undetectable		 3rf4B-1om9A:
25.75
3rf4C-1om9A:
25.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uiz MACROPHAGE MIGRATION
INHIBITORY FACTOR

(Xenopus laevis) 		PF01187
(MIF) 		5 PRO A   1
LYS A  32
SER A  63
ILE A  64
VAL A 106
 None
 0.47A 3rf4B-1uizA:
20.3
3rf4C-1uizA:
20.4		 3rf4B-1uizA:
33.04
3rf4C-1uizA:
33.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uiz MACROPHAGE MIGRATION
INHIBITORY FACTOR

(Xenopus laevis) 		PF01187
(MIF) 		5 PRO A   1
LYS A  32
SER A  63
ILE A  64
VAL A 106
 None
 1.35A 3rf4B-1uizA:
20.3
3rf4C-1uizA:
20.4		 3rf4B-1uizA:
33.04
3rf4C-1uizA:
33.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whm CYLINDROMATOSIS
TUMOR SUPPRESSOR
CYLD

(Homo sapiens) 		no annotation 5 ILE A  53
MET A  49
SER A  17
ILE A  24
VAL A  20
 None
 0.95A 3rf4B-1whmA:
undetectable
3rf4C-1whmA:
undetectable		 3rf4B-1whmA:
18.92
3rf4C-1whmA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whm CYLINDROMATOSIS
TUMOR SUPPRESSOR
CYLD

(Homo sapiens) 		no annotation 5 ILE A  53
MET A  49
SER A  26
ILE A  24
VAL A  20
 None
 1.32A 3rf4B-1whmA:
undetectable
3rf4C-1whmA:
undetectable		 3rf4B-1whmA:
18.92
3rf4C-1whmA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu7 HISTIDYL-TRNA
SYNTHETASE

(Thermoplasma
acidophilum) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 ILE A 273
PRO A 135
SER A 134
VAL A 308
VAL A 141
 None
 1.30A 3rf4B-1wu7A:
0.7
3rf4C-1wu7A:
undetectable		 3rf4B-1wu7A:
15.06
3rf4C-1wu7A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylococcus
capsulatus) 		PF02461
(AMO)
PF04744
(Monooxygenase_B) 		5 PRO B 170
SER B 179
ILE B 180
VAL A 170
VAL A 178
 None
 1.28A 3rf4B-1yewB:
undetectable
3rf4C-1yewB:
undetectable		 3rf4B-1yewB:
20.16
3rf4C-1yewB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 ILE A  36
SER A  25
ILE A  24
VAL A  40
VAL A 202
 None
 1.15A 3rf4B-1yj8A:
undetectable
3rf4C-1yj8A:
undetectable		 3rf4B-1yj8A:
16.14
3rf4C-1yj8A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Thermotoga
maritima) 		PF01513
(NAD_kinase) 		5 ILE A 134
SER A 181
ILE A 180
VAL A 136
VAL A 201
 None
 1.26A 3rf4B-1yt5A:
undetectable
3rf4C-1yt5A:
undetectable		 3rf4B-1yt5A:
17.44
3rf4C-1yt5A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yv9 HYDROLASE, HALOACID
DEHALOGENASE FAMILY

(Enterococcus
faecalis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 ILE A  94
ILE A 103
VAL A 119
PHE A  92
VAL A  91
 None
 1.11A 3rf4B-1yv9A:
undetectable
3rf4C-1yv9A:
undetectable		 3rf4B-1yv9A:
22.46
3rf4C-1yv9A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmr PHOSPHOGLYCERATE
KINASE

(Escherichia
coli) 		PF00162
(PGK) 		5 HIS A  59
ARG A  36
ILE A  37
VAL A  77
VAL A  31
 None
 1.26A 3rf4B-1zmrA:
undetectable
3rf4C-1zmrA:
undetectable		 3rf4B-1zmrA:
18.79
3rf4C-1zmrA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 224
SER A 166
ILE A 167
VAL A 222
VAL A 185
 None
 1.18A 3rf4B-2ac5A:
undetectable
3rf4C-2ac5A:
undetectable		 3rf4B-2ac5A:
16.72
3rf4C-2ac5A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36

(Canis lupus) 		PF03388
(Lectin_leg-like) 		5 ILE A 242
SER A 178
ILE A 159
VAL A 226
VAL A 217
 None
 1.30A 3rf4B-2dupA:
undetectable
3rf4C-2dupA:
undetectable		 3rf4B-2dupA:
17.08
3rf4C-2dupA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus) 		PF04452
(Methyltrans_RNA) 		5 ILE A  89
SER A 221
ILE A 222
VAL A 184
VAL A 182
 None
None
None
SAH  A 300 ( 3.7A)
None
 1.31A 3rf4B-2egwA:
undetectable
3rf4C-2egwA:
undetectable		 3rf4B-2egwA:
17.12
3rf4C-2egwA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE

(Pyrococcus
horikoshii) 		PF16363
(GDP_Man_Dehyd) 		5 ILE A  35
SER A  17
ILE A  20
VAL A   8
VAL A  32
 None
 1.36A 3rf4B-2hunA:
undetectable
3rf4C-2hunA:
undetectable		 3rf4B-2hunA:
15.48
3rf4C-2hunA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 ILE A  46
ILE A  88
VAL A  97
PHE A  98
VAL A 125
 SO4  A1373 (-4.5A)
None
None
None
None
 1.09A 3rf4B-2iu4A:
undetectable
3rf4C-2iu4A:
undetectable		 3rf4B-2iu4A:
16.67
3rf4C-2iu4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		5 HIS A  41
ILE A  15
ILE A 214
VAL A 114
VAL A 134
 None
 1.20A 3rf4B-2iyaA:
undetectable
3rf4C-2iyaA:
undetectable		 3rf4B-2iyaA:
13.79
3rf4C-2iyaA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jj4 ACETYLGLUTAMATE
KINASE

(Synechococcus
elongatus) 		PF00696
(AA_kinase) 		5 ILE A 195
SER A 174
ILE A 186
VAL A 136
VAL A 152
 None
NLG  A1292 (-3.2A)
None
None
None
 1.18A 3rf4B-2jj4A:
undetectable
3rf4C-2jj4A:
undetectable		 3rf4B-2jj4A:
17.76
3rf4C-2jj4A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qts ACID-SENSING ION
CHANNEL

(Gallus gallus) 		PF00858
(ASC) 		5 ILE A 246
ILE A 409
VAL A 248
PHE A  93
VAL A  91
 None
 1.03A 3rf4B-2qtsA:
undetectable
3rf4C-2qtsA:
undetectable		 3rf4B-2qtsA:
17.19
3rf4C-2qtsA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa2 TREHALOSE-SYNTHASE
TRET

(Pyrococcus
horikoshii) 		PF00534
(Glycos_transf_1) 		5 ILE A 221
SER A 316
ILE A 233
PHE A 225
VAL A 227
 None
 1.25A 3rf4B-2xa2A:
undetectable
3rf4C-2xa2A:
undetectable		 3rf4B-2xa2A:
14.80
3rf4C-2xa2A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 ILE A 737
MET A 517
VAL A 709
PHE A 707
VAL A 447
 None
 1.21A 3rf4B-2xt6A:
undetectable
3rf4C-2xt6A:
undetectable		 3rf4B-2xt6A:
7.92
3rf4C-2xt6A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adr PUTATIVE
UNCHARACTERIZED
PROTEIN ST1585

(Sulfurisphaera
tokodaii) 		PF00753
(Lactamase_B) 		5 PRO A 177
ILE A 231
VAL A 174
PHE A 171
VAL A 233
 None
 1.16A 3rf4B-3adrA:
undetectable
3rf4C-3adrA:
undetectable		 3rf4B-3adrA:
18.25
3rf4C-3adrA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bus METHYLTRANSFERASE

(Lechevalieria
aerocolonigenes) 		PF08241
(Methyltransf_11) 		5 ILE A 164
ARG A 145
ILE A 196
VAL A 266
VAL A 168
 None
 1.33A 3rf4B-3busA:
undetectable
3rf4C-3busA:
undetectable		 3rf4B-3busA:
18.22
3rf4C-3busA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db7 PUTATIVE
CALCIUM-REGULATED
PERIPLASMIC PROTEIN

(Bacteroides
thetaiotaomicron) 		PF11396
(PepSY_like) 		5 ILE A  26
MET A  31
ILE A  39
VAL A  64
VAL A  48
 None
 1.10A 3rf4B-3db7A:
undetectable
3rf4C-3db7A:
undetectable		 3rf4B-3db7A:
22.78
3rf4C-3db7A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		5 HIS A   5
ILE A  76
SER A 249
VAL A 102
VAL A 201
 None
 1.22A 3rf4B-3dqzA:
undetectable
3rf4C-3dqzA:
undetectable		 3rf4B-3dqzA:
17.97
3rf4C-3dqzA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 ARG A 220
SER A 218
ILE A 201
VAL A 187
VAL A 195
 None
 1.24A 3rf4B-3fefA:
undetectable
3rf4C-3fefA:
undetectable		 3rf4B-3fefA:
12.59
3rf4C-3fefA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs9 PROTEIN GP18

(Listeria
monocytogenes) 		PF06605
(Prophage_tail) 		5 ILE A  91
PRO A  89
SER A  37
ILE A  38
VAL A  61
 None
None
None
OCS  A  27 ( 4.2A)
None
 1.23A 3rf4B-3gs9A:
undetectable
3rf4C-3gs9A:
undetectable		 3rf4B-3gs9A:
15.52
3rf4C-3gs9A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gut TRANSCRIPTION FACTOR
P65

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		5 ILE A  23
ILE A  63
VAL A  21
PHE A 161
VAL A 163
 None
 1.15A 3rf4B-3gutA:
undetectable
3rf4C-3gutA:
undetectable		 3rf4B-3gutA:
16.73
3rf4C-3gutA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmq NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Salmonella
enterica) 		PF02540
(NAD_synthase) 		5 ILE A 111
SER A 148
ILE A 149
VAL A 109
VAL A  81
 None
 1.32A 3rf4B-3hmqA:
undetectable
3rf4C-3hmqA:
undetectable		 3rf4B-3hmqA:
17.34
3rf4C-3hmqA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irv CYSTEINE HYDROLASE

(Pseudomonas
savastanoi) 		PF00857
(Isochorismatase) 		5 ILE A 227
ARG A 185
VAL A 194
PHE A 231
VAL A 188
 None
 1.33A 3rf4B-3irvA:
undetectable
3rf4C-3irvA:
undetectable		 3rf4B-3irvA:
21.60
3rf4C-3irvA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		5 ILE A  85
SER A 138
ILE A 139
VAL A 222
VAL A  21
 None
 1.37A 3rf4B-3lylA:
undetectable
3rf4C-3lylA:
undetectable		 3rf4B-3lylA:
18.80
3rf4C-3lylA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca PROTEIN DOM34

(Schizosaccharomyces
pombe) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		5 ILE B 308
SER B 314
ILE B 362
VAL B 299
PHE B 303
 None
 1.22A 3rf4B-3mcaB:
undetectable
3rf4C-3mcaB:
undetectable		 3rf4B-3mcaB:
15.94
3rf4C-3mcaB:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ILE A 775
MET A 747
ILE A 799
VAL A 720
VAL A 764
 None
 0.86A 3rf4B-3o5aA:
undetectable
3rf4C-3o5aA:
undetectable		 3rf4B-3o5aA:
7.29
3rf4C-3o5aA:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens) 		PF01408
(GFO_IDH_MocA) 		5 HIS A 260
ILE A 261
MET A 263
ILE A 199
VAL A 203
 None
 1.33A 3rf4B-3oqbA:
undetectable
3rf4C-3oqbA:
undetectable		 3rf4B-3oqbA:
17.11
3rf4C-3oqbA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA

(Sulfolobus
solfataricus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		5 PRO A 350
ARG A 352
ILE A 351
VAL A 373
VAL A 370
 None
 1.35A 3rf4B-3penA:
undetectable
3rf4C-3penA:
undetectable		 3rf4B-3penA:
16.24
3rf4C-3penA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp7 PYRUVATE KINASE

(Leishmania
mexicana) 		PF00224
(PK)
PF02887
(PK_C) 		5 ILE A 252
SER A 283
ILE A 282
VAL A 292
VAL A 260
 None
 1.18A 3rf4B-3pp7A:
undetectable
3rf4C-3pp7A:
undetectable		 3rf4B-3pp7A:
11.64
3rf4C-3pp7A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv9 PYRUVATE KINASE 2

(Trypanosoma
cruzi) 		PF00224
(PK)
PF02887
(PK_C) 		5 ILE A 253
SER A 284
ILE A 283
VAL A 293
VAL A 261
 None
 1.25A 3rf4B-3qv9A:
undetectable
3rf4C-3qv9A:
undetectable		 3rf4B-3qv9A:
12.13
3rf4C-3qv9A:
12.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rf5 MACROPHAGE MIGRATION
INHIBITORY FACTOR

(Ancylostoma
ceylanicum) 		PF01187
(MIF) 		9 PRO A   1
MET A   2
LYS A  32
ARG A  36
SER A  63
ILE A  64
VAL A 106
PHE A 108
VAL A 113
 FUZ  A 202 (-3.7A)
FUZ  A 202 (-3.4A)
FUZ  A 202 (-2.7A)
None
FUZ  A 202 (-3.5A)
FUZ  A 202 (-3.8A)
None
FUZ  A 202 (-3.6A)
FUZ  A 202 (-4.6A)
 0.19A 3rf4B-3rf5A:
23.8
3rf4C-3rf5A:
23.7		 3rf4B-3rf5A:
100.00
3rf4C-3rf5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		5 ILE A  65
PRO A  84
ILE A 123
VAL A 107
VAL A 111
 None
 1.29A 3rf4B-3rjyA:
undetectable
3rf4C-3rjyA:
undetectable		 3rf4B-3rjyA:
14.95
3rf4C-3rjyA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 ARG X 431
SER X 428
ILE X 418
VAL X 472
VAL X 470
 None
 1.32A 3rf4B-3rwkX:
undetectable
3rf4C-3rwkX:
undetectable		 3rf4B-3rwkX:
13.80
3rf4C-3rwkX:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1v PROBABLE
TRANSALDOLASE

(Thermoplasma
acidophilum) 		PF00923
(TAL_FSA) 		5 ILE A 180
ARG A 176
ILE A 168
VAL A 165
VAL A 133
 GOL  A 225 (-4.7A)
GOL  A 224 ( 3.9A)
None
None
None
 1.17A 3rf4B-3s1vA:
undetectable
3rf4C-3s1vA:
undetectable		 3rf4B-3s1vA:
19.63
3rf4C-3s1vA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		5 ILE A 222
PRO A 147
ILE A 145
VAL A 151
VAL A 129
 None
 1.16A 3rf4B-3tlmA:
undetectable
3rf4C-3tlmA:
undetectable		 3rf4B-3tlmA:
9.86
3rf4C-3tlmA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 112
MET A  95
ILE A   8
VAL A 115
VAL A  24
 None
 1.26A 3rf4B-3tqpA:
undetectable
3rf4C-3tqpA:
undetectable		 3rf4B-3tqpA:
15.04
3rf4C-3tqpA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v10 RHUSIOPATHIAE
SURFACE PROTEIN B

(Erysipelothrix
rhusiopathiae) 		PF05737
(Collagen_bind) 		5 ILE A 216
ILE A 269
VAL A 292
PHE A 290
VAL A 246
 None
 1.04A 3rf4B-3v10A:
undetectable
3rf4C-3v10A:
undetectable		 3rf4B-3v10A:
17.69
3rf4C-3v10A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 ILE A 562
ARG A 555
SER A 557
ILE A 556
VAL A 524
 None
 1.18A 3rf4B-3vr5A:
undetectable
3rf4C-3vr5A:
undetectable		 3rf4B-3vr5A:
11.13
3rf4C-3vr5A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbq PHIKZ039

(Pseudomonas
virus phiKZ) 		no annotation 5 HIS A  27
ILE A   9
ILE A 182
VAL A 101
VAL A 130
 None
 1.19A 3rf4B-3zbqA:
undetectable
3rf4C-3zbqA:
undetectable		 3rf4B-3zbqA:
17.76
3rf4C-3zbqA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 ILE A 737
MET A 517
VAL A 709
PHE A 707
VAL A 447
 None
 1.22A 3rf4B-3zhrA:
undetectable
3rf4C-3zhrA:
undetectable		 3rf4B-3zhrA:
8.20
3rf4C-3zhrA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0t PUP--PROTEIN LIGASE

(Corynebacterium
glutamicum) 		PF03136
(Pup_ligase) 		5 ILE A 204
MET A 149
ILE A 266
VAL A 224
VAL A 189
 None
 1.18A 3rf4B-4b0tA:
0.9
3rf4C-4b0tA:
0.9		 3rf4B-4b0tA:
15.38
3rf4C-4b0tA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL

(Homo sapiens) 		PF00481
(PP2C) 		5 PRO A 219
SER A 306
ILE A 309
VAL A 294
PHE A 292
 None
 1.35A 3rf4B-4da1A:
undetectable
3rf4C-4da1A:
undetectable		 3rf4B-4da1A:
17.18
3rf4C-4da1A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 PRO A 161
ILE A 163
VAL A 169
PHE A 171
VAL A 197
 None
 1.13A 3rf4B-4dalA:
undetectable
3rf4C-4dalA:
undetectable		 3rf4B-4dalA:
14.61
3rf4C-4dalA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE

(Clostridioides
difficile) 		PF00155
(Aminotran_1_2) 		5 ILE A 116
ILE A 104
VAL A 128
PHE A 124
VAL A 127
 None
 1.26A 3rf4B-4dq6A:
undetectable
3rf4C-4dq6A:
undetectable		 3rf4B-4dq6A:
13.78
3rf4C-4dq6A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		5 PRO A 726
SER A 725
ILE A 701
VAL A 706
VAL A 677
 None
 1.20A 3rf4B-4ecnA:
undetectable
3rf4C-4ecnA:
undetectable		 3rf4B-4ecnA:
8.73
3rf4C-4ecnA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE

(Clostridioides
difficile) 		PF01869
(BcrAD_BadFG) 		5 ILE A 204
SER A 198
ILE A 230
VAL A 206
VAL A 210
 None
 1.37A 3rf4B-4ehtA:
undetectable
3rf4C-4ehtA:
undetectable		 3rf4B-4ehtA:
16.00
3rf4C-4ehtA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eku PROTEIN-TYROSINE
KINASE 2-BETA

(Homo sapiens) 		PF00373
(FERM_M) 		5 ILE A  80
SER A  73
ILE A  70
PHE A  45
VAL A  43
 None
 1.33A 3rf4B-4ekuA:
undetectable
3rf4C-4ekuA:
undetectable		 3rf4B-4ekuA:
13.98
3rf4C-4ekuA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		5 ILE A  32
SER A 196
ILE A 195
VAL A  27
VAL A  24
 None
 1.31A 3rf4B-4gekA:
undetectable
3rf4C-4gekA:
undetectable		 3rf4B-4gekA:
20.23
3rf4C-4gekA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		5 SER A 196
ILE A 195
VAL A  27
PHE A  28
VAL A  24
 None
None
None
GEK  A 302 (-4.9A)
None
 1.35A 3rf4B-4gekA:
undetectable
3rf4C-4gekA:
undetectable		 3rf4B-4gekA:
20.23
3rf4C-4gekA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gua NON-STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF01661
(Macro)
PF01707
(Peptidase_C9) 		5 PRO A1389
ARG A1387
ILE A1384
VAL A1412
VAL A1366
 None
 1.18A 3rf4B-4guaA:
undetectable
3rf4C-4guaA:
undetectable		 3rf4B-4guaA:
10.84
3rf4C-4guaA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hac MEVALONATE KINASE

(Methanosarcina
mazei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 PRO A 136
ILE A 150
VAL A 141
PHE A 144
VAL A 148
 None
 1.31A 3rf4B-4hacA:
undetectable
3rf4C-4hacA:
undetectable		 3rf4B-4hacA:
17.24
3rf4C-4hacA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyv PYRUVATE KINASE 1

(Trypanosoma
brucei) 		PF00224
(PK)
PF02887
(PK_C) 		5 ILE A 253
SER A 284
ILE A 283
VAL A 293
VAL A 261
 None
 1.23A 3rf4B-4hyvA:
undetectable
3rf4C-4hyvA:
undetectable		 3rf4B-4hyvA:
13.56
3rf4C-4hyvA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Synechococcus
elongatus) 		PF06745
(ATPase) 		5 ILE A 105
ILE A 130
VAL A  72
PHE A  73
VAL A 142
 None
 1.02A 3rf4B-4ijmA:
undetectable
3rf4C-4ijmA:
undetectable		 3rf4B-4ijmA:
13.48
3rf4C-4ijmA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksf MALONYL-COA
DECARBOXYLASE

(Agrobacterium
vitis) 		PF05292
(MCD)
PF17408
(MCD_N) 		5 SER A 237
ILE A 238
VAL A 262
PHE A 300
VAL A 301
 None
 1.33A 3rf4B-4ksfA:
undetectable
3rf4C-4ksfA:
undetectable		 3rf4B-4ksfA:
15.33
3rf4C-4ksfA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		5 ILE A 165
SER A 234
VAL A 241
PHE A 243
VAL A 265
 None
 0.98A 3rf4B-4kwgA:
undetectable
3rf4C-4kwgA:
undetectable		 3rf4B-4kwgA:
15.44
3rf4C-4kwgA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY

(Thermococcus
kodakarensis) 		PF00375
(SDF) 		5 ILE A 161
PRO A  77
SER A  76
ILE A  75
PHE A 304
 None
 1.25A 3rf4B-4ky0A:
undetectable
3rf4C-4ky0A:
undetectable		 3rf4B-4ky0A:
15.24
3rf4C-4ky0A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 HIS A 144
ILE A 147
SER A 129
ILE A 126
VAL A 107
 None
 1.24A 3rf4B-4lg4A:
undetectable
3rf4C-4lg4A:
0.9		 3rf4B-4lg4A:
17.99
3rf4C-4lg4A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5p NADPH DEHYDROGENASE

(Scheffersomyces
stipitis) 		PF00724
(Oxidored_FMN) 		5 SER A 284
ILE A 283
VAL A 308
PHE A 263
VAL A 267
 None
 1.26A 3rf4B-4m5pA:
undetectable
3rf4C-4m5pA:
undetectable		 3rf4B-4m5pA:
16.27
3rf4C-4m5pA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		5 ILE A 294
SER A 267
ILE A 268
VAL A 212
VAL A 252
 None
 1.27A 3rf4B-4n2cA:
undetectable
3rf4C-4n2cA:
undetectable		 3rf4B-4n2cA:
10.87
3rf4C-4n2cA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nat PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Staphylococcus
aureus) 		PF01467
(CTP_transf_like) 		5 ILE A 128
SER A 144
ILE A 143
VAL A 133
VAL A 136
 None
 1.33A 3rf4B-4natA:
undetectable
3rf4C-4natA:
undetectable		 3rf4B-4natA:
18.83
3rf4C-4natA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz2 ZMALDH

(Zea mays) 		PF00171
(Aldedh) 		5 ILE A 180
SER A 249
VAL A 256
PHE A 258
VAL A 280
 NAD  A 603 (-4.4A)
None
None
NAD  A 603 (-4.6A)
None
 0.89A 3rf4B-4pz2A:
undetectable
3rf4C-4pz2A:
undetectable		 3rf4B-4pz2A:
13.32
3rf4C-4pz2A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raa PUTATIVE EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF17170
(DUF5128) 		5 HIS A 239
ILE A 227
ILE A 235
PHE A 218
VAL A 230
 None
 1.31A 3rf4B-4raaA:
undetectable
3rf4C-4raaA:
undetectable		 3rf4B-4raaA:
15.15
3rf4C-4raaA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4reg UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01905
(DevR) 		5 ILE A   5
SER A 247
ILE A 243
VAL A 325
VAL A 329
 None
 1.37A 3rf4B-4regA:
undetectable
3rf4C-4regA:
undetectable		 3rf4B-4regA:
14.93
3rf4C-4regA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tm3 KTZI

(Kutzneria sp.
744) 		PF13434
(K_oxygenase) 		5 HIS A  12
ILE A 131
VAL A  17
PHE A  42
VAL A 128
 None
None
None
None
FAD  A 501 (-4.0A)
 1.31A 3rf4B-4tm3A:
undetectable
3rf4C-4tm3A:
undetectable		 3rf4B-4tm3A:
13.32
3rf4C-4tm3A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE

(Gemmata
obscuriglobus) 		PF00121
(TIM) 		5 HIS A 191
MET A 227
ILE A 250
VAL A  11
VAL A 237
 None
 1.33A 3rf4B-4y96A:
1.2
3rf4C-4y96A:
1.1		 3rf4B-4y96A:
18.92
3rf4C-4y96A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5

(Saccharomyces
cerevisiae) 		PF00533
(BRCT)
PF16893
(fn3_2) 		5 ILE A 174
SER A 193
ILE A 192
VAL A 176
VAL A 216
 None
 1.32A 3rf4B-4yg8A:
undetectable
3rf4C-4yg8A:
undetectable		 3rf4B-4yg8A:
16.78
3rf4C-4yg8A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 ILE e 479
SER e  64
ILE e  61
VAL e 124
VAL e 123
 None
 1.35A 3rf4B-5gw5e:
undetectable
3rf4C-5gw5e:
undetectable		 3rf4B-5gw5e:
14.13
3rf4C-5gw5e:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu7 PUTATIVE POLYKETIDE
SYNTHASE

(Brevibacillus
brevis) 		PF14765
(PS-DH) 		5 ILE A3099
SER A3053
ILE A3017
VAL A3029
VAL A3020
 None
 1.23A 3rf4B-5hu7A:
undetectable
3rf4C-5hu7A:
undetectable		 3rf4B-5hu7A:
15.82
3rf4C-5hu7A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00535
(Glycos_transf_2) 		5 ILE A  33
PRO A  67
SER A  66
ILE A  65
VAL A 145
 None
 1.15A 3rf4B-5jqxA:
undetectable
3rf4C-5jqxA:
undetectable		 3rf4B-5jqxA:
15.67
3rf4C-5jqxA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00535
(Glycos_transf_2) 		5 ILE A 133
SER A  46
ILE A  45
VAL A 145
VAL A 149
 None
 1.33A 3rf4B-5jqxA:
undetectable
3rf4C-5jqxA:
undetectable		 3rf4B-5jqxA:
15.67
3rf4C-5jqxA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kew VTRC PROTEIN

(Vibrio
parahaemolyticus) 		no annotation 5 HIS B  50
ILE B  69
ILE B 124
VAL B  83
VAL B 106
 6SB  B 301 (-2.9A)
6SB  B 301 (-3.3A)
6SB  B 301 (-4.2A)
None
None
 1.37A 3rf4B-5kewB:
undetectable
3rf4C-5kewB:
undetectable		 3rf4B-5kewB:
20.27
3rf4C-5kewB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o00 GLUTATHIONE
TRANSFERASE URE2P5

(Phanerochaete
chrysosporium) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ILE A 171
MET A  23
ARG A 210
ILE A 208
VAL A 174
 None
None
None
GOL  A 309 ( 3.7A)
None
 1.28A 3rf4B-5o00A:
undetectable
3rf4C-5o00A:
undetectable		 3rf4B-5o00A:
18.06
3rf4C-5o00A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		5 ILE A 222
ARG A 147
SER A 149
ILE A 145
VAL A 229
 HEM  A 600 ( 4.1A)
None
None
None
None
 1.13A 3rf4B-5o1mA:
undetectable
3rf4C-5o1mA:
undetectable		 3rf4B-5o1mA:
16.00
3rf4C-5o1mA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4
TRANSCRIPTION
ELONGATION FACTOR
SPT5

(Homo sapiens) 		PF00467
(KOW)
PF03439
(Spt5-NGN)
PF06093
(Spt4) 		5 ILE Z 201
SER Z 195
ILE Z 194
VAL Y   6
VAL Y  84
 None
 1.30A 3rf4B-5oikZ:
undetectable
3rf4C-5oikZ:
undetectable		 3rf4B-5oikZ:
8.19
3rf4C-5oikZ:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME

(Trypanosoma
brucei) 		PF01536
(SAM_decarbox) 		5 ILE A 287
MET A 194
ILE A 261
VAL A 290
VAL A 231
 None
 1.17A 3rf4B-5tvoA:
undetectable
3rf4C-5tvoA:
undetectable		 3rf4B-5tvoA:
19.37
3rf4C-5tvoA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME

(Trypanosoma
brucei) 		PF01536
(SAM_decarbox) 		5 ILE A 287
SER A 273
ILE A 261
VAL A 290
VAL A 231
 None
 1.10A 3rf4B-5tvoA:
undetectable
3rf4C-5tvoA:
undetectable		 3rf4B-5tvoA:
19.37
3rf4C-5tvoA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub6 PHOSPHATE-BINDING
PROTEIN

(Xanthomonas
citri) 		no annotation 5 ILE A 231
SER A 136
ILE A 134
VAL A 128
VAL A 207
 None
 1.30A 3rf4B-5ub6A:
undetectable
3rf4C-5ub6A:
2.1		 3rf4B-5ub6A:
25.22
3rf4C-5ub6A:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 ILE A 159
ILE A 233
VAL A 243
PHE A 244
VAL A 440
 None
 1.06A 3rf4B-5vj7A:
undetectable
3rf4C-5vj7A:
undetectable		 3rf4B-5vj7A:
14.41
3rf4C-5vj7A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vq5 ADHESIN

(Escherichia
coli) 		no annotation 5 ILE A  95
SER A  67
ILE A  68
VAL A 146
VAL A  33
 None
 0.91A 3rf4B-5vq5A:
undetectable
3rf4C-5vq5A:
undetectable		 3rf4B-5vq5A:
22.05
3rf4C-5vq5A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyw RHINO

(Drosophila
simulans) 		no annotation 5 PRO A 475
ILE A 479
VAL A 463
PHE A 462
VAL A 450
 None
 1.36A 3rf4B-5xywA:
undetectable
3rf4C-5xywA:
undetectable		 3rf4B-5xywA:
15.65
3rf4C-5xywA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2e DIHYDRODIPICOLINATE
REDUCTASE

(Paenisporosarcina
sp. TG-14) 		no annotation 5 SER A 246
ILE A 247
VAL A  71
PHE A  72
VAL A   4
 None
 0.97A 3rf4B-5z2eA:
2.2
3rf4C-5z2eA:
2.4		 3rf4B-5z2eA:
24.35
3rf4C-5z2eA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 5 HIS A 144
ILE A 147
SER A 129
ILE A 126
VAL A 107
 None
 1.36A 3rf4B-6ao5A:
undetectable
3rf4C-6ao5A:
undetectable		 3rf4B-6ao5A:
16.14
3rf4C-6ao5A:
16.14