SIMILAR PATTERNS OF AMINO ACIDS FOR 3RF4_A_FUNA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a87 COLICIN N

(Escherichia
coli) 		PF01024
(Colicin) 		5 SER A 364
ILE A 363
VAL A 225
VAL A 203
ILE A 370
 None
 1.23A 3rf4A-1a87A:
undetectable
3rf4C-1a87A:
undetectable		 3rf4A-1a87A:
15.61
3rf4C-1a87A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c25 CDC25A

(Homo sapiens) 		PF00581
(Rhodanese) 		5 PRO A 361
SER A 360
ILE A 359
VAL A 427
ILE A 395
 None
 1.31A 3rf4A-1c25A:
0.7
3rf4C-1c25A:
0.7		 3rf4A-1c25A:
18.01
3rf4C-1c25A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqj SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 SER A 185
ILE A 119
VAL A 175
VAL A 126
ILE A   2
 None
 1.26A 3rf4A-1cqjA:
0.0
3rf4C-1cqjA:
0.0		 3rf4A-1cqjA:
14.54
3rf4C-1cqjA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		5 SER A 469
ILE A 492
VAL A 521
VAL A 532
ILE A 498
 None
 1.29A 3rf4A-1gq1A:
undetectable
3rf4C-1gq1A:
undetectable		 3rf4A-1gq1A:
14.48
3rf4C-1gq1A:
14.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfo MIGRATION INHIBITORY
FACTOR

(Trichinella
spiralis) 		PF01187
(MIF) 		5 PRO A   1
LYS A  32
SER A  63
ILE A  64
VAL A 106
 None
 0.21A 3rf4A-1hfoA:
19.5
3rf4C-1hfoA:
19.6		 3rf4A-1hfoA:
30.09
3rf4C-1hfoA:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg0 L-ASPARAGINASE

(Dickeya
chrysanthemi) 		PF00710
(Asparaginase) 		5 SER A  74
VAL A 115
VAL A 152
HIS A  93
ILE A  91
 None
 1.22A 3rf4A-1hg0A:
0.5
3rf4C-1hg0A:
0.0		 3rf4A-1hg0A:
18.33
3rf4C-1hg0A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 SER A 285
ILE A 284
VAL A 237
VAL A 169
ILE A 166
 None
 1.37A 3rf4A-1iyxA:
0.6
3rf4C-1iyxA:
0.5		 3rf4A-1iyxA:
13.46
3rf4C-1iyxA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 SER A 494
ILE A 493
VAL A 479
PHE A 610
VAL A 459
 None
 1.20A 3rf4A-1k72A:
0.0
3rf4C-1k72A:
undetectable		 3rf4A-1k72A:
11.41
3rf4C-1k72A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		5 SER A 151
VAL A 122
PHE A 165
VAL A 163
ILE A 124
 None
 1.25A 3rf4A-1l1lA:
0.1
3rf4C-1l1lA:
0.2		 3rf4A-1l1lA:
11.61
3rf4C-1l1lA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lo9 4-HYDROXYBENZOYL-COA
THIOESTERASE

(Pseudomonas sp.
CBS3) 		no annotation 5 SER A  97
VAL A 110
PHE A  68
VAL A  69
HIS A  28
 None
 1.23A 3rf4A-1lo9A:
undetectable
3rf4C-1lo9A:
undetectable		 3rf4A-1lo9A:
22.07
3rf4C-1lo9A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9j ALDEHYDE
DEHYDROGENASE,
CYTOSOLIC 1

(Elephantulus
edwardii) 		PF00171
(Aldedh) 		5 SER A 234
VAL A 241
PHE A 243
VAL A 265
ILE A 165
 None
None
NAD  A1501 (-4.5A)
None
NAD  A1501 (-4.5A)
 1.06A 3rf4A-1o9jA:
undetectable
3rf4C-1o9jA:
undetectable		 3rf4A-1o9jA:
15.80
3rf4C-1o9jA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1om9 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1

(Homo sapiens) 		PF02883
(Alpha_adaptinC2) 		5 PRO A 503
SER A 506
ILE A 507
VAL A 542
VAL A 544
 None
 1.33A 3rf4A-1om9A:
undetectable
3rf4C-1om9A:
undetectable		 3rf4A-1om9A:
25.75
3rf4C-1om9A:
25.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uiz MACROPHAGE MIGRATION
INHIBITORY FACTOR

(Xenopus laevis) 		PF01187
(MIF) 		5 PRO A   1
LYS A  32
SER A  63
ILE A  64
VAL A 106
 None
 0.50A 3rf4A-1uizA:
20.3
3rf4C-1uizA:
20.4		 3rf4A-1uizA:
33.04
3rf4C-1uizA:
33.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uiz MACROPHAGE MIGRATION
INHIBITORY FACTOR

(Xenopus laevis) 		PF01187
(MIF) 		5 PRO A   1
LYS A  32
SER A  63
ILE A  64
VAL A 106
 None
 1.38A 3rf4A-1uizA:
20.3
3rf4C-1uizA:
20.4		 3rf4A-1uizA:
33.04
3rf4C-1uizA:
33.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whm CYLINDROMATOSIS
TUMOR SUPPRESSOR
CYLD

(Homo sapiens) 		no annotation 5 MET A  49
SER A  17
ILE A  24
VAL A  20
ILE A  53
 None
 0.95A 3rf4A-1whmA:
undetectable
3rf4C-1whmA:
undetectable		 3rf4A-1whmA:
18.92
3rf4C-1whmA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whm CYLINDROMATOSIS
TUMOR SUPPRESSOR
CYLD

(Homo sapiens) 		no annotation 5 MET A  49
SER A  26
ILE A  24
VAL A  20
ILE A  53
 None
 1.28A 3rf4A-1whmA:
undetectable
3rf4C-1whmA:
undetectable		 3rf4A-1whmA:
18.92
3rf4C-1whmA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu7 HISTIDYL-TRNA
SYNTHETASE

(Thermoplasma
acidophilum) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 PRO A 135
SER A 134
VAL A 308
VAL A 141
ILE A 273
 None
 1.28A 3rf4A-1wu7A:
0.9
3rf4C-1wu7A:
undetectable		 3rf4A-1wu7A:
15.06
3rf4C-1wu7A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylococcus
capsulatus) 		PF02461
(AMO)
PF04744
(Monooxygenase_B) 		5 PRO B 170
SER B 179
ILE B 180
VAL A 170
VAL A 178
 None
 1.32A 3rf4A-1yewB:
undetectable
3rf4C-1yewB:
undetectable		 3rf4A-1yewB:
20.16
3rf4C-1yewB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 SER A  25
ILE A  24
VAL A  40
VAL A 202
ILE A  36
 None
 1.17A 3rf4A-1yj8A:
undetectable
3rf4C-1yj8A:
undetectable		 3rf4A-1yj8A:
16.14
3rf4C-1yj8A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Thermotoga
maritima) 		PF01513
(NAD_kinase) 		5 SER A 181
ILE A 180
VAL A 136
VAL A 201
ILE A 134
 None
 1.27A 3rf4A-1yt5A:
undetectable
3rf4C-1yt5A:
undetectable		 3rf4A-1yt5A:
17.44
3rf4C-1yt5A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yv9 HYDROLASE, HALOACID
DEHALOGENASE FAMILY

(Enterococcus
faecalis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 ILE A 103
VAL A 119
PHE A  92
VAL A  91
ILE A  94
 None
 1.11A 3rf4A-1yv9A:
undetectable
3rf4C-1yv9A:
undetectable		 3rf4A-1yv9A:
22.46
3rf4C-1yv9A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 SER A 166
ILE A 167
VAL A 222
VAL A 185
ILE A 224
 None
 1.25A 3rf4A-2ac5A:
undetectable
3rf4C-2ac5A:
undetectable		 3rf4A-2ac5A:
16.72
3rf4C-2ac5A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c20 UDP-GLUCOSE
4-EPIMERASE

(Bacillus
anthracis) 		PF01370
(Epimerase) 		5 SER A  15
ILE A  13
VAL A 227
VAL A 172
HIS A 321
 None
NAD  A 401 (-3.8A)
None
NAD  A 401 (-3.9A)
None
 1.27A 3rf4A-2c20A:
undetectable
3rf4C-2c20A:
undetectable		 3rf4A-2c20A:
14.83
3rf4C-2c20A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36

(Canis lupus) 		PF03388
(Lectin_leg-like) 		5 SER A 178
ILE A 159
VAL A 226
VAL A 217
ILE A 242
 None
 1.37A 3rf4A-2dupA:
undetectable
3rf4C-2dupA:
undetectable		 3rf4A-2dupA:
17.08
3rf4C-2dupA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus) 		PF04452
(Methyltrans_RNA) 		5 SER A 221
ILE A 222
VAL A 184
VAL A 182
ILE A  89
 None
None
SAH  A 300 ( 3.7A)
None
None
 1.35A 3rf4A-2egwA:
undetectable
3rf4C-2egwA:
undetectable		 3rf4A-2egwA:
17.12
3rf4C-2egwA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE

(Pyrococcus
horikoshii) 		PF16363
(GDP_Man_Dehyd) 		5 SER A  17
ILE A  20
VAL A   8
VAL A  32
ILE A  35
 None
 1.39A 3rf4A-2hunA:
undetectable
3rf4C-2hunA:
undetectable		 3rf4A-2hunA:
15.48
3rf4C-2hunA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihd REGULATOR OF
G-PROTEIN SIGNALING
8

(Homo sapiens) 		PF00615
(RGS) 		5 ILE A 123
VAL A 113
PHE A 112
VAL A 121
ILE A 108
 None
 1.24A 3rf4A-2ihdA:
undetectable
3rf4C-2ihdA:
undetectable		 3rf4A-2ihdA:
19.75
3rf4C-2ihdA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 ILE A  88
VAL A  97
PHE A  98
VAL A 125
ILE A  46
 None
None
None
None
SO4  A1373 (-4.5A)
 1.09A 3rf4A-2iu4A:
undetectable
3rf4C-2iu4A:
undetectable		 3rf4A-2iu4A:
16.67
3rf4C-2iu4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		5 ILE A 214
VAL A 114
VAL A 134
HIS A  41
ILE A  15
 None
 1.24A 3rf4A-2iyaA:
undetectable
3rf4C-2iyaA:
undetectable		 3rf4A-2iyaA:
13.79
3rf4C-2iyaA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jj4 ACETYLGLUTAMATE
KINASE

(Synechococcus
elongatus) 		PF00696
(AA_kinase) 		5 SER A 174
ILE A 186
VAL A 136
VAL A 152
ILE A 195
 NLG  A1292 (-3.2A)
None
None
None
None
 1.17A 3rf4A-2jj4A:
undetectable
3rf4C-2jj4A:
undetectable		 3rf4A-2jj4A:
17.76
3rf4C-2jj4A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4c ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27

(Homo sapiens) 		PF13848
(Thioredoxin_6) 		5 SER A 108
ILE A 111
VAL A  35
PHE A  62
VAL A  60
 None
 1.32A 3rf4A-2l4cA:
undetectable
3rf4C-2l4cA:
undetectable		 3rf4A-2l4cA:
23.08
3rf4C-2l4cA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o08 BH1327 PROTEIN

(Bacillus
halodurans) 		PF01966
(HD) 		5 PRO A 131
ARG A 133
ILE A 129
VAL A 138
PHE A 135
 None
PO4  A 500 (-3.1A)
None
None
None
 1.34A 3rf4A-2o08A:
undetectable
3rf4C-2o08A:
undetectable		 3rf4A-2o08A:
24.23
3rf4C-2o08A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjv UNCHARACTERIZED
IOLB-LIKE PROTEIN

(Salmonella
enterica) 		PF04962
(KduI) 		5 PRO A  77
ARG A  80
SER A  76
HIS A 140
ILE A  81
 None
SO4  A 276 (-3.8A)
None
None
None
 1.38A 3rf4A-2qjvA:
undetectable
3rf4C-2qjvA:
undetectable		 3rf4A-2qjvA:
18.87
3rf4C-2qjvA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qts ACID-SENSING ION
CHANNEL

(Gallus gallus) 		PF00858
(ASC) 		5 ILE A 409
VAL A 248
PHE A  93
VAL A  91
ILE A 246
 None
 1.04A 3rf4A-2qtsA:
undetectable
3rf4C-2qtsA:
undetectable		 3rf4A-2qtsA:
17.19
3rf4C-2qtsA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 MET A 517
VAL A 709
PHE A 707
VAL A 447
ILE A 737
 None
 1.21A 3rf4A-2xt6A:
undetectable
3rf4C-2xt6A:
undetectable		 3rf4A-2xt6A:
7.92
3rf4C-2xt6A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adr PUTATIVE
UNCHARACTERIZED
PROTEIN ST1585

(Sulfurisphaera
tokodaii) 		PF00753
(Lactamase_B) 		5 PRO A 177
ILE A 231
VAL A 174
PHE A 171
VAL A 233
 None
 1.19A 3rf4A-3adrA:
undetectable
3rf4C-3adrA:
undetectable		 3rf4A-3adrA:
18.25
3rf4C-3adrA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346

(Corynebacterium
diphtheriae) 		PF08903
(DUF1846) 		5 ARG A 308
SER A 484
VAL A 347
VAL A 346
ILE A 307
 None
 1.40A 3rf4A-3bh1A:
undetectable
3rf4C-3bh1A:
undetectable		 3rf4A-3bh1A:
12.43
3rf4C-3bh1A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db7 PUTATIVE
CALCIUM-REGULATED
PERIPLASMIC PROTEIN

(Bacteroides
thetaiotaomicron) 		PF11396
(PepSY_like) 		5 MET A  31
ILE A  39
VAL A  64
VAL A  48
ILE A  26
 None
 1.08A 3rf4A-3db7A:
undetectable
3rf4C-3db7A:
undetectable		 3rf4A-3db7A:
22.78
3rf4C-3db7A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		5 SER A 249
VAL A 102
VAL A 201
HIS A   5
ILE A  76
 None
 1.24A 3rf4A-3dqzA:
undetectable
3rf4C-3dqzA:
undetectable		 3rf4A-3dqzA:
17.97
3rf4C-3dqzA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 ARG A 220
SER A 218
ILE A 201
VAL A 187
VAL A 195
 None
 1.17A 3rf4A-3fefA:
undetectable
3rf4C-3fefA:
undetectable		 3rf4A-3fefA:
12.59
3rf4C-3fefA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs9 PROTEIN GP18

(Listeria
monocytogenes) 		PF06605
(Prophage_tail) 		5 PRO A  89
SER A  37
ILE A  38
VAL A  61
ILE A  91
 None
None
OCS  A  27 ( 4.2A)
None
None
 1.21A 3rf4A-3gs9A:
undetectable
3rf4C-3gs9A:
undetectable		 3rf4A-3gs9A:
15.52
3rf4C-3gs9A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irv CYSTEINE HYDROLASE

(Pseudomonas
savastanoi) 		PF00857
(Isochorismatase) 		5 ARG A 185
VAL A 194
PHE A 231
VAL A 188
ILE A 227
 None
 1.35A 3rf4A-3irvA:
undetectable
3rf4C-3irvA:
undetectable		 3rf4A-3irvA:
21.60
3rf4C-3irvA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Thermococcus
kodakarensis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ILE A  39
VAL A  87
PHE A  29
VAL A  31
ILE A  89
 None
 1.37A 3rf4A-3kdnA:
undetectable
3rf4C-3kdnA:
undetectable		 3rf4A-3kdnA:
13.46
3rf4C-3kdnA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		5 SER A 138
ILE A 139
VAL A 222
VAL A  21
ILE A  85
 None
 1.35A 3rf4A-3lylA:
undetectable
3rf4C-3lylA:
undetectable		 3rf4A-3lylA:
18.80
3rf4C-3lylA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca PROTEIN DOM34

(Schizosaccharomyces
pombe) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		5 SER B 314
ILE B 362
VAL B 299
PHE B 303
ILE B 308
 None
 1.17A 3rf4A-3mcaB:
undetectable
3rf4C-3mcaB:
undetectable		 3rf4A-3mcaB:
15.94
3rf4C-3mcaB:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 MET A 747
ILE A 799
VAL A 720
VAL A 764
ILE A 775
 None
 0.88A 3rf4A-3o5aA:
undetectable
3rf4C-3o5aA:
undetectable		 3rf4A-3o5aA:
7.29
3rf4C-3o5aA:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens) 		PF01408
(GFO_IDH_MocA) 		5 MET A 263
ILE A 199
VAL A 203
HIS A 260
ILE A 261
 None
 1.33A 3rf4A-3oqbA:
undetectable
3rf4C-3oqbA:
undetectable		 3rf4A-3oqbA:
17.11
3rf4C-3oqbA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA

(Sulfolobus
solfataricus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		5 PRO A 350
ARG A 352
ILE A 351
VAL A 373
VAL A 370
 None
 1.38A 3rf4A-3penA:
undetectable
3rf4C-3penA:
undetectable		 3rf4A-3penA:
16.24
3rf4C-3penA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp7 PYRUVATE KINASE

(Leishmania
mexicana) 		PF00224
(PK)
PF02887
(PK_C) 		5 SER A 283
ILE A 282
VAL A 292
VAL A 260
ILE A 252
 None
 1.14A 3rf4A-3pp7A:
undetectable
3rf4C-3pp7A:
undetectable		 3rf4A-3pp7A:
11.64
3rf4C-3pp7A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv9 PYRUVATE KINASE 2

(Trypanosoma
cruzi) 		PF00224
(PK)
PF02887
(PK_C) 		5 SER A 284
ILE A 283
VAL A 293
VAL A 261
ILE A 253
 None
 1.22A 3rf4A-3qv9A:
undetectable
3rf4C-3qv9A:
undetectable		 3rf4A-3qv9A:
12.13
3rf4C-3qv9A:
12.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rf5 MACROPHAGE MIGRATION
INHIBITORY FACTOR

(Ancylostoma
ceylanicum) 		PF01187
(MIF) 		9 PRO A   1
MET A   2
LYS A  32
ARG A  36
SER A  63
ILE A  64
VAL A 106
PHE A 108
VAL A 113
 FUZ  A 202 (-3.7A)
FUZ  A 202 (-3.4A)
FUZ  A 202 (-2.7A)
None
FUZ  A 202 (-3.5A)
FUZ  A 202 (-3.8A)
None
FUZ  A 202 (-3.6A)
FUZ  A 202 (-4.6A)
 0.15A 3rf4A-3rf5A:
24.0
3rf4C-3rf5A:
23.7		 3rf4A-3rf5A:
100.00
3rf4C-3rf5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		5 PRO A  84
ILE A 123
VAL A 107
VAL A 111
ILE A  65
 None
 1.29A 3rf4A-3rjyA:
undetectable
3rf4C-3rjyA:
undetectable		 3rf4A-3rjyA:
14.95
3rf4C-3rjyA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 ARG X 431
SER X 428
ILE X 418
VAL X 472
VAL X 470
 None
 1.29A 3rf4A-3rwkX:
undetectable
3rf4C-3rwkX:
undetectable		 3rf4A-3rwkX:
13.80
3rf4C-3rwkX:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1v PROBABLE
TRANSALDOLASE

(Thermoplasma
acidophilum) 		PF00923
(TAL_FSA) 		5 ARG A 176
ILE A 168
VAL A 165
VAL A 133
ILE A 180
 GOL  A 224 ( 3.9A)
None
None
None
GOL  A 225 (-4.7A)
 1.16A 3rf4A-3s1vA:
undetectable
3rf4C-3s1vA:
undetectable		 3rf4A-3s1vA:
19.63
3rf4C-3s1vA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Enterobacter
sp. 638) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 MET A  74
ILE A   9
VAL A  93
VAL A  24
ILE A  90
 None
 1.12A 3rf4A-3tjiA:
undetectable
3rf4C-3tjiA:
undetectable		 3rf4A-3tjiA:
14.69
3rf4C-3tjiA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 MET A  95
ILE A   8
VAL A 115
VAL A  24
ILE A 112
 None
 1.26A 3rf4A-3tqpA:
undetectable
3rf4C-3tqpA:
undetectable		 3rf4A-3tqpA:
15.04
3rf4C-3tqpA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v10 RHUSIOPATHIAE
SURFACE PROTEIN B

(Erysipelothrix
rhusiopathiae) 		PF05737
(Collagen_bind) 		5 ILE A 269
VAL A 292
PHE A 290
VAL A 246
ILE A 216
 None
 1.08A 3rf4A-3v10A:
undetectable
3rf4C-3v10A:
undetectable		 3rf4A-3v10A:
17.69
3rf4C-3v10A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 ARG A 555
SER A 557
ILE A 556
VAL A 524
ILE A 562
 None
 1.23A 3rf4A-3vr5A:
undetectable
3rf4C-3vr5A:
undetectable		 3rf4A-3vr5A:
11.13
3rf4C-3vr5A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbq PHIKZ039

(Pseudomonas
virus phiKZ) 		no annotation 5 ILE A 182
VAL A 101
VAL A 130
HIS A  27
ILE A   9
 None
 1.22A 3rf4A-3zbqA:
undetectable
3rf4C-3zbqA:
undetectable		 3rf4A-3zbqA:
17.76
3rf4C-3zbqA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 MET A 517
VAL A 709
PHE A 707
VAL A 447
ILE A 737
 None
 1.23A 3rf4A-3zhrA:
undetectable
3rf4C-3zhrA:
undetectable		 3rf4A-3zhrA:
8.20
3rf4C-3zhrA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0t PUP--PROTEIN LIGASE

(Corynebacterium
glutamicum) 		PF03136
(Pup_ligase) 		5 MET A 149
ILE A 266
VAL A 224
VAL A 189
ILE A 204
 None
 1.20A 3rf4A-4b0tA:
1.1
3rf4C-4b0tA:
0.9		 3rf4A-4b0tA:
15.38
3rf4C-4b0tA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btg MAJOR INNER PROTEIN
P1

(Pseudomonas
virus phi6) 		no annotation 5 PRO A 554
SER A 347
ILE A 349
HIS A 497
ILE A 549
 None
 1.21A 3rf4A-4btgA:
undetectable
3rf4C-4btgA:
undetectable		 3rf4A-4btgA:
10.62
3rf4C-4btgA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL

(Homo sapiens) 		PF00481
(PP2C) 		5 PRO A 219
SER A 306
ILE A 309
VAL A 294
PHE A 292
 None
 1.36A 3rf4A-4da1A:
undetectable
3rf4C-4da1A:
undetectable		 3rf4A-4da1A:
17.18
3rf4C-4da1A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 PRO A 161
ILE A 163
VAL A 169
PHE A 171
VAL A 197
 None
 1.16A 3rf4A-4dalA:
undetectable
3rf4C-4dalA:
undetectable		 3rf4A-4dalA:
14.61
3rf4C-4dalA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dap SUGAR FERMENTATION
STIMULATION PROTEIN
A

(Escherichia
coli) 		PF03749
(SfsA) 		5 PRO A 231
ILE A 185
VAL A 180
PHE A 178
VAL A 139
 None
 1.17A 3rf4A-4dapA:
undetectable
3rf4C-4dapA:
undetectable		 3rf4A-4dapA:
19.73
3rf4C-4dapA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		5 PRO A 726
SER A 725
ILE A 701
VAL A 706
VAL A 677
 None
 1.21A 3rf4A-4ecnA:
undetectable
3rf4C-4ecnA:
undetectable		 3rf4A-4ecnA:
8.73
3rf4C-4ecnA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE

(Clostridioides
difficile) 		PF01869
(BcrAD_BadFG) 		5 SER A 198
ILE A 230
VAL A 206
VAL A 210
ILE A 204
 None
 1.37A 3rf4A-4ehtA:
undetectable
3rf4C-4ehtA:
undetectable		 3rf4A-4ehtA:
16.00
3rf4C-4ehtA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eku PROTEIN-TYROSINE
KINASE 2-BETA

(Homo sapiens) 		PF00373
(FERM_M) 		5 SER A  73
ILE A  70
PHE A  45
VAL A  43
ILE A  80
 None
 1.29A 3rf4A-4ekuA:
undetectable
3rf4C-4ekuA:
undetectable		 3rf4A-4ekuA:
13.98
3rf4C-4ekuA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		5 SER A 196
ILE A 195
VAL A  27
PHE A  28
VAL A  24
 None
None
None
GEK  A 302 (-4.9A)
None
 1.38A 3rf4A-4gekA:
undetectable
3rf4C-4gekA:
undetectable		 3rf4A-4gekA:
20.23
3rf4C-4gekA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gua NON-STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF01661
(Macro)
PF01707
(Peptidase_C9) 		5 PRO A1389
ARG A1387
ILE A1384
VAL A1412
VAL A1366
 None
 1.22A 3rf4A-4guaA:
undetectable
3rf4C-4guaA:
undetectable		 3rf4A-4guaA:
10.84
3rf4C-4guaA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hac MEVALONATE KINASE

(Methanosarcina
mazei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 PRO A 136
ILE A 150
VAL A 141
PHE A 144
VAL A 148
 None
 1.33A 3rf4A-4hacA:
undetectable
3rf4C-4hacA:
undetectable		 3rf4A-4hacA:
17.24
3rf4C-4hacA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyv PYRUVATE KINASE 1

(Trypanosoma
brucei) 		PF00224
(PK)
PF02887
(PK_C) 		5 SER A 284
ILE A 283
VAL A 293
VAL A 261
ILE A 253
 None
 1.19A 3rf4A-4hyvA:
undetectable
3rf4C-4hyvA:
undetectable		 3rf4A-4hyvA:
13.56
3rf4C-4hyvA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Synechococcus
elongatus) 		PF06745
(ATPase) 		5 ILE A 130
VAL A  72
PHE A  73
VAL A 142
ILE A 105
 None
 1.06A 3rf4A-4ijmA:
undetectable
3rf4C-4ijmA:
undetectable		 3rf4A-4ijmA:
13.48
3rf4C-4ijmA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksf MALONYL-COA
DECARBOXYLASE

(Agrobacterium
vitis) 		PF05292
(MCD)
PF17408
(MCD_N) 		5 SER A 237
ILE A 238
VAL A 262
PHE A 300
VAL A 301
 None
 1.37A 3rf4A-4ksfA:
undetectable
3rf4C-4ksfA:
undetectable		 3rf4A-4ksfA:
15.33
3rf4C-4ksfA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 SER A 129
ILE A 126
VAL A 107
HIS A 144
ILE A 147
 None
 1.23A 3rf4A-4lg4A:
0.9
3rf4C-4lg4A:
undetectable		 3rf4A-4lg4A:
17.99
3rf4C-4lg4A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5p NADPH DEHYDROGENASE

(Scheffersomyces
stipitis) 		PF00724
(Oxidored_FMN) 		5 SER A 284
ILE A 283
VAL A 308
PHE A 263
VAL A 267
 None
 1.26A 3rf4A-4m5pA:
undetectable
3rf4C-4m5pA:
undetectable		 3rf4A-4m5pA:
16.27
3rf4C-4m5pA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		5 SER A 267
ILE A 268
VAL A 212
VAL A 252
ILE A 294
 None
 1.27A 3rf4A-4n2cA:
undetectable
3rf4C-4n2cA:
undetectable		 3rf4A-4n2cA:
10.87
3rf4C-4n2cA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nat PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Staphylococcus
aureus) 		PF01467
(CTP_transf_like) 		5 SER A 144
ILE A 143
VAL A 133
VAL A 136
ILE A 128
 None
 1.29A 3rf4A-4natA:
undetectable
3rf4C-4natA:
undetectable		 3rf4A-4natA:
18.83
3rf4C-4natA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz2 ZMALDH

(Zea mays) 		PF00171
(Aldedh) 		5 SER A 249
VAL A 256
PHE A 258
VAL A 280
ILE A 180
 None
None
NAD  A 603 (-4.6A)
None
NAD  A 603 (-4.4A)
 0.88A 3rf4A-4pz2A:
undetectable
3rf4C-4pz2A:
undetectable		 3rf4A-4pz2A:
13.32
3rf4C-4pz2A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tm3 KTZI

(Kutzneria sp.
744) 		PF13434
(K_oxygenase) 		5 ILE A 131
VAL A  17
PHE A  42
VAL A 128
HIS A  12
 None
None
None
FAD  A 501 (-4.0A)
None
 1.32A 3rf4A-4tm3A:
undetectable
3rf4C-4tm3A:
undetectable		 3rf4A-4tm3A:
13.32
3rf4C-4tm3A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		5 MET A 508
SER A 443
ILE A 446
VAL A 420
VAL A 454
 None
 1.31A 3rf4A-4xbrA:
undetectable
3rf4C-4xbrA:
undetectable		 3rf4A-4xbrA:
15.84
3rf4C-4xbrA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE

(Gemmata
obscuriglobus) 		PF00121
(TIM) 		5 MET A 227
ILE A 250
VAL A  11
VAL A 237
HIS A 191
 None
 1.32A 3rf4A-4y96A:
1.2
3rf4C-4y96A:
undetectable		 3rf4A-4y96A:
18.92
3rf4C-4y96A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlr BRAIN TUMOR PROTEIN

(Drosophila
melanogaster) 		PF01436
(NHL) 		5 ILE A 973
VAL A 963
PHE A 929
VAL A 938
ILE A 965
 None
None
None
None
SO4  A1107 (-4.9A)
 1.22A 3rf4A-4zlrA:
undetectable
3rf4C-4zlrA:
undetectable		 3rf4A-4zlrA:
17.99
3rf4C-4zlrA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 SER e  64
ILE e  61
VAL e 124
VAL e 123
ILE e 479
 None
 1.39A 3rf4A-5gw5e:
undetectable
3rf4C-5gw5e:
undetectable		 3rf4A-5gw5e:
14.13
3rf4C-5gw5e:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu7 PUTATIVE POLYKETIDE
SYNTHASE

(Brevibacillus
brevis) 		PF14765
(PS-DH) 		5 SER A3053
ILE A3017
VAL A3029
VAL A3020
ILE A3099
 None
 1.26A 3rf4A-5hu7A:
undetectable
3rf4C-5hu7A:
undetectable		 3rf4A-5hu7A:
15.82
3rf4C-5hu7A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00535
(Glycos_transf_2) 		5 PRO A  67
SER A  66
ILE A  65
VAL A 145
ILE A  33
 None
 1.19A 3rf4A-5jqxA:
undetectable
3rf4C-5jqxA:
undetectable		 3rf4A-5jqxA:
15.67
3rf4C-5jqxA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00535
(Glycos_transf_2) 		5 SER A  46
ILE A  45
VAL A 145
VAL A 149
ILE A 133
 None
 1.33A 3rf4A-5jqxA:
undetectable
3rf4C-5jqxA:
undetectable		 3rf4A-5jqxA:
15.67
3rf4C-5jqxA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kew VTRC PROTEIN

(Vibrio
parahaemolyticus) 		no annotation 5 ILE B 124
VAL B  83
VAL B 106
HIS B  50
ILE B  69
 6SB  B 301 (-4.2A)
None
None
6SB  B 301 (-2.9A)
6SB  B 301 (-3.3A)
 1.40A 3rf4A-5kewB:
undetectable
3rf4C-5kewB:
undetectable		 3rf4A-5kewB:
20.27
3rf4C-5kewB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o00 GLUTATHIONE
TRANSFERASE URE2P5

(Phanerochaete
chrysosporium) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 MET A  23
ARG A 210
ILE A 208
VAL A 174
ILE A 171
 None
None
GOL  A 309 ( 3.7A)
None
None
 1.26A 3rf4A-5o00A:
undetectable
3rf4C-5o00A:
undetectable		 3rf4A-5o00A:
18.06
3rf4C-5o00A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		5 ARG A 147
SER A 149
ILE A 145
VAL A 229
ILE A 222
 None
None
None
None
HEM  A 600 ( 4.1A)
 1.15A 3rf4A-5o1mA:
undetectable
3rf4C-5o1mA:
undetectable		 3rf4A-5o1mA:
16.00
3rf4C-5o1mA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4
TRANSCRIPTION
ELONGATION FACTOR
SPT5

(Homo sapiens) 		PF00467
(KOW)
PF03439
(Spt5-NGN)
PF06093
(Spt4) 		5 SER Z 195
ILE Z 194
VAL Y   6
VAL Y  84
ILE Z 201
 None
 1.27A 3rf4A-5oikZ:
undetectable
3rf4C-5oikZ:
undetectable		 3rf4A-5oikZ:
8.19
3rf4C-5oikZ:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		5 SER A 174
ILE A 172
VAL A  89
VAL A 133
ILE A  30
 None
 1.38A 3rf4A-5thmA:
1.2
3rf4C-5thmA:
1.1		 3rf4A-5thmA:
12.76
3rf4C-5thmA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME

(Trypanosoma
brucei) 		PF01536
(SAM_decarbox) 		5 MET A 194
ILE A 261
VAL A 290
VAL A 231
ILE A 287
 None
 1.14A 3rf4A-5tvoA:
undetectable
3rf4C-5tvoA:
undetectable		 3rf4A-5tvoA:
19.37
3rf4C-5tvoA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub6 PHOSPHATE-BINDING
PROTEIN

(Xanthomonas
citri) 		no annotation 5 SER A 136
ILE A 134
VAL A 128
VAL A 207
ILE A 231
 None
 1.27A 3rf4A-5ub6A:
undetectable
3rf4C-5ub6A:
2.1		 3rf4A-5ub6A:
25.22
3rf4C-5ub6A:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 ILE A 233
VAL A 243
PHE A 244
VAL A 440
ILE A 159
 None
 1.09A 3rf4A-5vj7A:
undetectable
3rf4C-5vj7A:
undetectable		 3rf4A-5vj7A:
14.41
3rf4C-5vj7A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vq5 ADHESIN

(Escherichia
coli) 		no annotation 5 SER A  67
ILE A  68
VAL A 146
VAL A  33
ILE A  95
 None
 0.96A 3rf4A-5vq5A:
undetectable
3rf4C-5vq5A:
undetectable		 3rf4A-5vq5A:
22.05
3rf4C-5vq5A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vto BLASTICIDIN M

(Streptomyces
griseochromogenes) 		no annotation 5 ILE A 160
VAL A  89
PHE A  90
VAL A  18
ILE A 116
 None
 1.39A 3rf4A-5vtoA:
undetectable
3rf4C-5vtoA:
undetectable		 3rf4A-5vtoA:
20.33
3rf4C-5vtoA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wro ENOLASE

(Drosophila
melanogaster) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 MET A 161
ILE A  73
VAL A 181
VAL A  89
ILE A 178
 None
 1.24A 3rf4A-5wroA:
undetectable
3rf4C-5wroA:
undetectable		 3rf4A-5wroA:
18.90
3rf4C-5wroA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2e DIHYDRODIPICOLINATE
REDUCTASE

(Paenisporosarcina
sp. TG-14) 		no annotation 5 SER A 246
ILE A 247
VAL A  71
PHE A  72
VAL A   4
 None
 0.99A 3rf4A-5z2eA:
undetectable
3rf4C-5z2eA:
2.4		 3rf4A-5z2eA:
24.35
3rf4C-5z2eA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 5 SER A 129
ILE A 126
VAL A 107
HIS A 144
ILE A 147
 None
 1.32A 3rf4A-6ao5A:
undetectable
3rf4C-6ao5A:
undetectable		 3rf4A-6ao5A:
16.14
3rf4C-6ao5A:
16.14