SIMILAR PATTERNS OF AMINO ACIDS FOR 3RC0_A_SAMA484_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c9e | PROTOHEME FERROLYASE (Bacillussubtilis) |
PF00762(Ferrochelatase) | 5 | VAL A 10GLY A 85ALA A 57TYR A 17LEU A 67 | None | 1.23A | 3rc0A-1c9eA:undetectable | 3rc0A-1c9eA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1evq | SERINE HYDROLASE (Alicyclobacillusacidocaldarius) |
PF07859(Abhydrolase_3) | 5 | ALA A 156GLY A 157TYR A 80ALA A 116PHE A 214 | EPE A 455 (-3.8A)NoneNoneNoneEPE A 455 (-4.8A) | 1.15A | 3rc0A-1evqA:undetectable | 3rc0A-1evqA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fdr | FLAVODOXIN REDUCTASE (Escherichiacoli) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | ALA A 117GLY A 213ALA A 51LEU A 19TYR A 52 | NoneNoneFAD A 249 (-3.8A)NoneFAD A 249 (-4.4A) | 1.21A | 3rc0A-1fdrA:0.0 | 3rc0A-1fdrA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gve | AFLATOXIN B1ALDEHYDE REDUCTASEMEMBER 3 (Rattusnorvegicus) |
PF00248(Aldo_ket_red) | 5 | VAL A 281ALA A 280TYR A 107TYR A 164PHE A 190 | None | 1.15A | 3rc0A-1gveA:undetectable | 3rc0A-1gveA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gz7 | LIPASE 2 (Diutina rugosa) |
PF00135(COesterase) | 5 | ALA A 210GLY A 122ALA A 159LEU A 302TYR A 306 | None | 1.25A | 3rc0A-1gz7A:0.0 | 3rc0A-1gz7A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hg3 | TRIOSEPHOSPHATEISOMERASE (Pyrococcuswoesei) |
PF00121(TIM)PF05690(ThiG) | 5 | VAL A 90ALA A 89GLY A 88ALA A 28LEU A 4 | None | 1.23A | 3rc0A-1hg3A:undetectable | 3rc0A-1hg3A:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jji | CARBOXYLESTERASE (Archaeoglobusfulgidus) |
PF07859(Abhydrolase_3) | 5 | ALA A 161GLY A 162TYR A 85ALA A 121PHE A 218 | EPE A 455 (-3.4A)NoneNoneNoneEPE A 455 ( 4.9A) | 1.19A | 3rc0A-1jjiA:undetectable | 3rc0A-1jjiA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5q | PROTEASOME BETA-TYPESUBUNIT 1 (Rhodococcuserythropolis) |
PF00227(Proteasome) | 5 | VAL H 4ALA H 15GLY H 16ALA H 214LEU H 150 | None | 1.19A | 3rc0A-1q5qH:undetectable | 3rc0A-1q5qH:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5r | PROTEASOME BETA-TYPESUBUNIT 1 (Rhodococcuserythropolis) |
PF00227(Proteasome) | 5 | VAL H 4ALA H 15GLY H 16ALA H 214LEU H 150 | None | 1.23A | 3rc0A-1q5rH:undetectable | 3rc0A-1q5rH:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v7v | CHITOBIOSEPHOSPHORYLASE (Vibrioproteolyticus) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 5 | ALA A 469GLY A 381TYR A 382ALA A 352LEU A 512 | None | 1.15A | 3rc0A-1v7vA:undetectable | 3rc0A-1v7vA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wcg | THIOGLUCOSIDASE (Brevicorynebrassicae) |
PF00232(Glyco_hydro_1) | 5 | VAL A 136ALA A 194GLY A 195LEU A 184TYR A 180 | None | 1.22A | 3rc0A-1wcgA:undetectable | 3rc0A-1wcgA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wdw | TRYPTOPHAN SYNTHASEALPHA CHAIN (Pyrococcusfuriosus) |
PF00290(Trp_syntA) | 5 | VAL A 200GLY A 220TYR A 10ALA A 32LEU A 209 | None | 1.24A | 3rc0A-1wdwA:undetectable | 3rc0A-1wdwA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bhm | TYPE IV SECRETIONSYSTEM PROTEIN VIRB8 (Brucella suis) |
PF04335(VirB8) | 5 | VAL A 163TYR A 117TYR A 141TYR A 229TYR A 110 | None | 1.16A | 3rc0A-2bhmA:undetectable | 3rc0A-2bhmA:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bp1 | AFLATOXIN B1ALDEHYDE REDUCTASEMEMBER 2 (Homo sapiens) |
PF00248(Aldo_ket_red) | 5 | VAL A 314ALA A 313TYR A 140TYR A 197PHE A 223 | None | 1.18A | 3rc0A-2bp1A:undetectable | 3rc0A-2bp1A:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c7b | CARBOXYLESTERASE (unculturedarchaeon) |
PF07859(Abhydrolase_3) | 5 | ALA A 155GLY A 156TYR A 79ALA A 115PHE A 214 | None | 1.21A | 3rc0A-2c7bA:undetectable | 3rc0A-2c7bA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c91 | AFLATOXIN B1ALDEHYDE REDUCTASEMEMBER 2 (Mus musculus) |
PF00248(Aldo_ket_red) | 5 | VAL A 281ALA A 280TYR A 107TYR A 164PHE A 190 | None | 1.14A | 3rc0A-2c91A:undetectable | 3rc0A-2c91A:23.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cc3 | PROTEIN VIRB8 (Agrobacteriumtumefaciens) |
PF04335(VirB8) | 5 | VAL A 160TYR A 112TYR A 136TYR A 222TYR A 105 | None | 1.25A | 3rc0A-2cc3A:undetectable | 3rc0A-2cc3A:15.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2clp | AFLATOXIN B1ALDEHYDE REDUCTASEMEMBER 3 (Homo sapiens) |
PF00248(Aldo_ket_red) | 5 | VAL A 314ALA A 313TYR A 140TYR A 197PHE A 223 | None | 1.14A | 3rc0A-2clpA:undetectable | 3rc0A-2clpA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fj0 | CARBOXYLIC ESTERHYDROLASE (Manduca sexta) |
PF00135(COesterase) | 5 | ALA A 194GLY A 195TYR A 175ALA A 61TYR A 60 | None | 1.13A | 3rc0A-2fj0A:undetectable | 3rc0A-2fj0A:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g2o | MALONYL COA-ACYLCARRIER PROTEINTRANSACYLASE (Escherichiacoli) |
PF00698(Acyl_transf_1) | 5 | ALA A 5ALA A 102LEU A 297TYR A 74PHE A 8 | None | 1.21A | 3rc0A-2g2oA:undetectable | 3rc0A-2g2oA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h21 | RIBULOSE-1,5BISPHOSPHATECARBOXYLASE/OXYGENASE (Pisum sativum) |
PF00856(SET)PF09273(Rubis-subs-bind) | 5 | GLY A 81ASN A 242TYR A 287TYR A 300PHE A 302 | SAM A 801 (-3.7A)SAM A 801 (-2.9A)SAM A 801 (-4.8A)NoneSAM A 801 (-3.9A) | 0.53A | 3rc0A-2h21A:29.4 | 3rc0A-2h21A:25.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ipj | ALDO-KETO REDUCTASEFAMILY 1 MEMBER C2 (Homo sapiens) |
PF00248(Aldo_ket_red) | 5 | GLY A 62ALA A 24LEU A 40TYR A 272PHE A 21 | NoneNAP A 1 (-3.3A)NoneNoneNone | 1.18A | 3rc0A-2ipjA:undetectable | 3rc0A-2ipjA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jbm | NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE (Homo sapiens) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 5 | VAL A 136ALA A 159GLY A 158ALA A 278LEU A 258 | None | 1.15A | 3rc0A-2jbmA:undetectable | 3rc0A-2jbmA:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o3i | HYPOTHETICAL PROTEIN (Chromobacteriumviolaceum) |
PF06032(DUF917) | 5 | VAL A 138ALA A 137GLY A 24ALA A 229LEU A 364 | None | 1.25A | 3rc0A-2o3iA:undetectable | 3rc0A-2o3iA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2of5 | LEUCINE-RICH REPEATAND DEATHDOMAIN-CONTAININGPROTEIN (Homo sapiens) |
PF00531(Death) | 5 | VAL H 795ALA H 796GLY H 797LEU H 787PHE H 837 | None | 1.04A | 3rc0A-2of5H:undetectable | 3rc0A-2of5H:14.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oi6 | BIFUNCTIONAL PROTEINGLMU (Escherichiacoli) |
PF00132(Hexapep)PF12804(NTP_transf_3) | 5 | VAL A 344ALA A 361GLY A 362LEU A 332TYR A 366 | None | 1.26A | 3rc0A-2oi6A:undetectable | 3rc0A-2oi6A:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ooc | HISTIDINEPHOSPHOTRANSFERASE (Caulobactervibrioides) |
PF01627(Hpt) | 5 | VAL A 65ALA A 62GLY A 60ALA A 41LEU A 30 | None | 1.10A | 3rc0A-2oocA:undetectable | 3rc0A-2oocA:14.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vkn | PROTEIN SSU81 (Saccharomycescerevisiae) |
PF00018(SH3_1) | 5 | VAL A 33ALA A 43ALA A 15TYR A 13PHE A 25 | None | 0.94A | 3rc0A-2vknA:undetectable | 3rc0A-2vknA:7.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w38 | SIALIDASE (Pseudomonasaeruginosa) |
PF13088(BNR_2) | 5 | ALA A 323TYR A 297ASN A 311LEU A 11TYR A 36 | None | 1.26A | 3rc0A-2w38A:undetectable | 3rc0A-2w38A:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x9x | CELL WALL SURFACEANCHOR FAMILYPROTEIN (Streptococcuspneumoniae) |
PF16569(GramPos_pilinBB)PF16570(GramPos_pilinD3) | 5 | VAL A 298LEU A 281TYR A 234TYR A 324PHE A 322 | None | 1.25A | 3rc0A-2x9xA:undetectable | 3rc0A-2x9xA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x9z | CELL WALL SURFACEANCHOR FAMILYPROTEIN (Streptococcuspneumoniae) |
PF16569(GramPos_pilinBB)PF16570(GramPos_pilinD3) | 5 | VAL A 298LEU A 281TYR A 234TYR A 324PHE A 322 | None | 1.21A | 3rc0A-2x9zA:undetectable | 3rc0A-2x9zA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xsj | SULFITE REDUCTASEALPHA SUBUNITSULFITE REDUCTASEBETA SUBUNIT (Desulfomicrobiumnorvegicum;Desulfomicrobiumnorvegicum) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr)PF01077(NIR_SIR)PF03460(NIR_SIR_ferr)PF12838(Fer4_7) | 5 | VAL A 102ALA A 103ALA B 26LEU A 118TYR A 110 | None | 1.19A | 3rc0A-2xsjA:undetectable | 3rc0A-2xsjA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yh2 | ESTERASE (Pyrobaculumcalidifontis) |
PF07859(Abhydrolase_3) | 5 | ALA A 158GLY A 159TYR A 82ALA A 118PHE A 217 | None | 1.12A | 3rc0A-2yh2A:undetectable | 3rc0A-2yh2A:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z4t | BETA-GALACTOSIDEALPHA-2,6-SIALYLTRANSFERASE (Photobacteriumsp. JT-ISH-224) |
PF11477(PM0188) | 5 | GLY A 233LEU A 304TYR A 280TYR A 290PHE A 292 | GOL A3004 (-3.3A)NoneNoneNoneNone | 1.16A | 3rc0A-2z4tA:undetectable | 3rc0A-2z4tA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zal | L-ASPARAGINASE (Escherichiacoli) |
PF01112(Asparaginase_2) | 5 | VAL A 73ALA A 72GLY A 71ALA A 84ASN A 67 | NoneNone NA A 800 ( 4.4A)NoneNone | 1.18A | 3rc0A-2zalA:undetectable | 3rc0A-2zalA:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ahi | XYLULOSE5-PHOSPHATE/FRUCTOSE6-PHOSPHATEPHOSPHOKETOLASE (Bifidobacteriumbreve) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 5 | GLY A 216TYR A 217ALA A 249LEU A 71PHE A 296 | None | 1.24A | 3rc0A-3ahiA:undetectable | 3rc0A-3ahiA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ail | 303AA LONGHYPOTHETICALESTERASE (Sulfurisphaeratokodaii) |
PF07859(Abhydrolase_3) | 5 | ALA A 151GLY A 152TYR A 76ALA A 112PHE A 206 | DEP A 304 (-3.5A)NoneNoneNoneDEP A 304 (-4.5A) | 1.16A | 3rc0A-3ailA:undetectable | 3rc0A-3ailA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3baz | HYDROXYPHENYLPYRUVATE REDUCTASE (Plectranthusscutellarioides) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | VAL A 201ALA A 202GLY A 151ALA A 163LEU A 227 | NoneNoneNAP A 500 (-3.5A)NoneNone | 1.21A | 3rc0A-3bazA:undetectable | 3rc0A-3bazA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c17 | L-ASPARAGINASEPRECURSOR (Escherichiacoli) |
PF01112(Asparaginase_2) | 5 | VAL A 73ALA A 72GLY A 71ALA A 84ASN A 67 | NoneNone NA A 1 ( 4.4A)NoneNone | 1.14A | 3rc0A-3c17A:undetectable | 3rc0A-3c17A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dbk | ELASTASE (Pseudomonasaeruginosa) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 5 | VAL A 272ALA A 269GLY A 268ALA A 213LEU A 236 | None | 1.09A | 3rc0A-3dbkA:1.4 | 3rc0A-3dbkA:16.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ele | AMINO TRANSFERASE ([Eubacterium]rectale) |
PF00155(Aminotran_1_2) | 5 | VAL A 275ALA A 278GLY A 279ALA A 142LEU A 240 | None | 1.15A | 3rc0A-3eleA:undetectable | 3rc0A-3eleA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fpk | FERREDOXIN-NADPREDUCTASE (Salmonellaenterica) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | ALA A 117GLY A 213ALA A 51LEU A 19TYR A 52 | NoneNoneFAD A 301 (-3.5A)NoneFAD A 301 (-4.4A) | 1.22A | 3rc0A-3fpkA:undetectable | 3rc0A-3fpkA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ho8 | PYRUVATE CARBOXYLASE (Staphylococcusaureus) |
PF00289(Biotin_carb_N)PF00682(HMGL-like)PF02436(PYC_OADA)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | VAL A 693ALA A 696GLY A 697ALA A 669LEU A 643 | None | 1.11A | 3rc0A-3ho8A:undetectable | 3rc0A-3ho8A:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icq | EXPORTIN-T (Schizosaccharomycespombe) |
PF08389(Xpo1) | 5 | VAL T 150GLY T 155ALA T 179LEU T 131TYR T 120 | None | 1.26A | 3rc0A-3icqT:undetectable | 3rc0A-3icqT:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ie1 | RIBONUCLEASETTHA0252 (Thermusthermophilus) |
PF00753(Lactamase_B)PF07521(RMMBL)PF10996(Beta-Casp) | 5 | ALA A 16GLY A 7ALA A 43LEU A 68PHE A 45 | None | 1.16A | 3rc0A-3ie1A:undetectable | 3rc0A-3ie1A:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kda | CFTR INHIBITORYFACTOR (CIF) (Pseudomonasaeruginosa) |
no annotation | 5 | GLY D 92ALA D 37TYR D 38LEU D 110TYR D 48 | None | 1.18A | 3rc0A-3kdaD:undetectable | 3rc0A-3kdaD:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kdn | RIBULOSEBISPHOSPHATECARBOXYLASE (Thermococcuskodakarensis) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | ALA A 43GLY A 44TYR A 12ALA A 27TYR A 91 | None | 1.06A | 3rc0A-3kdnA:undetectable | 3rc0A-3kdnA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kzu | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)SYNTHASE II (Brucellamelitensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | VAL A 193ALA A 194GLY A 195LEU A 91TYR A 262 | None | 1.19A | 3rc0A-3kzuA:undetectable | 3rc0A-3kzuA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3loy | COPPER AMINE OXIDASE (Ogataea angusta) |
PF01179(Cu_amine_oxid) | 5 | ALA A 310GLY A 309LEU A 13TYR A 66TYR A 68 | NoneNoneNoneGOL A 636 (-4.2A)None | 1.20A | 3rc0A-3loyA:undetectable | 3rc0A-3loyA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n71 | HISTONE LYSINEMETHYLTRANSFERASESMYD1 (Mus musculus) |
PF00856(SET)PF01753(zf-MYND) | 5 | GLY A 18ASN A 205TYR A 252TYR A 270PHE A 272 | SFG A 491 ( 4.2A)SFG A 491 (-3.3A)SFG A 491 (-4.8A)NoneSFG A 491 (-3.7A) | 0.48A | 3rc0A-3n71A:11.8 | 3rc0A-3n71A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oyt | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE I (Yersinia pestis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | VAL A 239ALA A 188GLY A 189ALA A 398LEU A 348 | None | 1.21A | 3rc0A-3oytA:undetectable | 3rc0A-3oytA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q75 | FARNESYLTRANSFERASEBETA SUBUNIT (Cryptococcusneoformans) |
PF00432(Prenyltrans) | 5 | VAL B 500GLY B 332ALA B 297ASN B 275LEU B 279 | None | 1.23A | 3rc0A-3q75B:undetectable | 3rc0A-3q75B:23.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3rc0 | N-LYSINEMETHYLTRANSFERASESETD6 (Homo sapiens) |
PF00856(SET)PF09273(Rubis-subs-bind) | 11 | VAL A 72ALA A 73GLY A 74TYR A 75ALA A 222TYR A 223ASN A 251LEU A 253TYR A 285TYR A 297PHE A 299 | SAM A 484 (-4.6A)SAM A 484 (-3.3A)SAM A 484 (-3.4A)NoneSAM A 484 (-3.5A)SAM A 484 (-3.6A)SAM A 484 (-3.1A)NoneSAM A 484 (-4.8A)NoneSAM A 484 (-3.5A) | 0.02A | 3rc0A-3rc0A:61.3 | 3rc0A-3rc0A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqp | ENOLASE (Coxiellaburnetii) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | VAL A 119ALA A 118GLY A 34TYR A 33LEU A 80 | None | 1.01A | 3rc0A-3tqpA:undetectable | 3rc0A-3tqpA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v76 | FLAVOPROTEIN (Sinorhizobiummeliloti) |
PF03486(HI0933_like) | 5 | VAL A 159ALA A 160GLY A 12ALA A 24LEU A 363 | NoneNoneFDA A 547 (-3.4A)NoneNone | 1.11A | 3rc0A-3v76A:undetectable | 3rc0A-3v76A:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vgl | GLUCOKINASE (Streptomycesgriseus) |
PF00480(ROK) | 5 | ALA A 152GLY A 147ALA A 110LEU A 250PHE A 155 | None | 1.18A | 3rc0A-3vglA:undetectable | 3rc0A-3vglA:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vns | NRPS ADENYLATIONPROTEIN CYTC1 (Streptomycessp.) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | TYR A 307ALA A 330ASN A 305LEU A 303TYR A 325 | AMP A 601 (-4.9A)NoneAMP A 601 (-3.6A)NoneNone | 1.19A | 3rc0A-3vnsA:undetectable | 3rc0A-3vnsA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w9v | PHOSPHATE-BINDINGPROTEIN (unidentifiedprokaryoticorganism) |
PF12849(PBP_like_2) | 5 | VAL A 89ALA A 90GLY A 297ALA A 248LEU A 13 | None | 1.19A | 3rc0A-3w9vA:undetectable | 3rc0A-3w9vA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3waf | IRON ABCTRANSPORTER,PERIPLASMICIRON-BINDING PROTEIN (Thermusthermophilus) |
PF13416(SBP_bac_8) | 5 | ALA A 250GLY A 249ALA A 274TYR A 268PHE A 265 | None | 1.18A | 3rc0A-3wafA:undetectable | 3rc0A-3wafA:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wsb | FARNESYLTRANSFERASE,PUTATIVE (Trypanosomacruzi) |
PF00494(SQS_PSY) | 5 | VAL A 167ALA A 168GLY A 169ALA A 260TYR A 160 | RWZ A 502 (-4.3A)FPS A 501 (-4.7A)NoneNoneNone | 1.15A | 3rc0A-3wsbA:undetectable | 3rc0A-3wsbA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxx | AOPB (Aeromonashydrophila) |
PF04888(SseC) | 5 | VAL B 241ALA B 240GLY B 244ALA B 99LEU B 86 | None | 1.25A | 3rc0A-3wxxB:undetectable | 3rc0A-3wxxB:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x0v | L-LYSINE OXIDASE (Trichodermaviride) |
PF01593(Amino_oxidase) | 5 | VAL A 17GLY A 47TYR A 50LEU A 81TYR A 69 | FAD A 601 (-4.4A)FAD A 601 (-3.4A)NoneNoneFAD A 601 (-4.3A) | 1.12A | 3rc0A-3x0vA:undetectable | 3rc0A-3x0vA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4akz | TYPE IV SECRETIONSYSTEM PROTEIN VIRB8 (Brucella suis) |
PF04335(VirB8) | 5 | VAL A 163TYR A 117TYR A 141TYR A 229TYR A 110 | None | 1.16A | 3rc0A-4akzA:undetectable | 3rc0A-4akzA:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4at0 | 3-KETOSTEROID-DELTA4-5ALPHA-DEHYDROGENASE (Rhodococcusjostii) |
PF00890(FAD_binding_2) | 5 | ALA A 63GLY A 64ALA A 292TYR A 466PHE A 427 | FAD A1493 (-3.3A)ACT A1491 ( 3.2A)NoneACT A1490 ( 4.4A)FAD A1493 (-4.2A) | 1.22A | 3rc0A-4at0A:undetectable | 3rc0A-4at0A:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bk1 | PROBABLE SALICYLATEMONOOXYGENASE (Rhodococcusjostii) |
PF01494(FAD_binding_3) | 5 | VAL A 44ALA A 46GLY A 47ALA A 229TYR A 186 | None | 1.22A | 3rc0A-4bk1A:undetectable | 3rc0A-4bk1A:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c1q | HISTONE-LYSINEN-METHYLTRANSFERASEPRDM9 (Mus musculus) |
PF00856(SET) | 5 | ALA A 256GLY A 257TYR A 291ASN A 320TYR A 357 | SAH A 394 (-3.6A)SAH A 394 ( 3.7A)SAH A 394 (-3.9A)SAH A 394 (-3.4A)None | 0.76A | 3rc0A-4c1qA:5.6 | 3rc0A-4c1qA:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d9i | DIAMINOPROPIONATEAMMONIA-LYASE (Escherichiacoli) |
PF00291(PALP) | 5 | VAL A 342ALA A 341GLY A 320TYR A 385LEU A 289 | NoneNoneNoneNoneLLP A 77 (-4.8A) | 1.25A | 3rc0A-4d9iA:undetectable | 3rc0A-4d9iA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hyj | RHODOPSIN (Exiguobacteriumsibiricum) |
PF01036(Bac_rhodopsin) | 5 | ALA A 64GLY A 76LEU A 211TYR A 58PHE A 15 | None | 1.24A | 3rc0A-4hyjA:undetectable | 3rc0A-4hyjA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i9a | QUINOLINATEPHOSPHORIBOSYLTRANSFERASE (Sus scrofa) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 5 | VAL A 134ALA A 157GLY A 156ALA A 276LEU A 256 | None | 1.14A | 3rc0A-4i9aA:undetectable | 3rc0A-4i9aA:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jb6 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Pseudomonasaeruginosa) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | VAL A 86ALA A 85GLY A 10ALA A 174LEU A 151 | None | 1.20A | 3rc0A-4jb6A:undetectable | 3rc0A-4jb6A:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jz2 | SUPEROXIDE DISMUTASE (Clostridioidesdifficile) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 5 | VAL A 101ALA A 105GLY A 106LEU A 78PHE A 32 | None | 1.18A | 3rc0A-4jz2A:undetectable | 3rc0A-4jz2A:15.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kc5 | RHIE PROTEIN (Paraburkholderiarhizoxinica) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | VAL A3299ALA A3252GLY A3253ALA A3485LEU A3418 | None | 1.26A | 3rc0A-4kc5A:undetectable | 3rc0A-4kc5A:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m7e | PROTEINBRASSINOSTEROIDINSENSITIVE 1 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF12799(LRR_4)PF13516(LRR_6)PF13855(LRR_8) | 5 | VAL A 332ALA A 331GLY A 330TYR A 329LEU A 345 | None | 1.15A | 3rc0A-4m7eA:undetectable | 3rc0A-4m7eA:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n6k | TRAP DICARBOXYLATETRANSPORTER-DCTPSUBUNIT (Desulfovibriosalexigens) |
PF03480(DctP) | 5 | GLY A 243TYR A 149ALA A 76TYR A 77PHE A 98 | NoneNoneNoneX3X A 401 (-4.5A)X3X A 401 (-4.5A) | 1.23A | 3rc0A-4n6kA:0.1 | 3rc0A-4n6kA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o6q | HASAP (Pseudomonasaeruginosa) |
PF06438(HasA) | 5 | GLY A 139TYR A 138ALA A 57TYR A 56LEU A 119 | NoneHEM A 202 (-3.6A)NoneHEM A 202 ( 3.7A)None | 1.21A | 3rc0A-4o6qA:undetectable | 3rc0A-4o6qA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qfw | ACYL-COATHIOESTERASE II (Yersinia pestis) |
PF13622(4HBT_3) | 5 | GLY A 37ALA A 46TYR A 76LEU A 9TYR A 45 | None | 1.14A | 3rc0A-4qfwA:undetectable | 3rc0A-4qfwA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qji | PHOSPHOPANTOTHENOYLCYSTEINEDECARBOXYLASE/PHOSPHOPANTOTHENATE--CYSTEINE LIGASE (Mycolicibacteriumsmegmatis) |
PF04127(DFP) | 5 | VAL A 190ALA A 230GLY A 229ALA A 398LEU A 409 | None | 1.06A | 3rc0A-4qjiA:undetectable | 3rc0A-4qjiA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qyr | AT-LESS POLYKETIDESYNTHASE (Streptomycesplatensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | VAL A2781ALA A2735GLY A2736ALA A2968LEU A2905 | None | 1.18A | 3rc0A-4qyrA:undetectable | 3rc0A-4qyrA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r84 | SIALYLTRANSFERASE0160 (Photobacteriumdamselae) |
PF11477(PM0188) | 5 | GLY A 230LEU A 300TYR A 276TYR A 286PHE A 288 | None | 1.05A | 3rc0A-4r84A:undetectable | 3rc0A-4r84A:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9v | SIALYLTRANSFERASE0160 (Photobacteriumdamselae) |
PF11477(PM0188) | 5 | GLY A 230LEU A 300TYR A 276TYR A 286PHE A 288 | None | 1.07A | 3rc0A-4r9vA:undetectable | 3rc0A-4r9vA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rnh | MOTILITY REGULATOR (Pseudomonasaeruginosa) |
PF00563(EAL)PF00990(GGDEF) | 5 | TYR A1143ALA A1078ASN A1148LEU A1152PHE A1140 | None | 1.13A | 3rc0A-4rnhA:undetectable | 3rc0A-4rnhA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uhm | OMEGA AMINOACID-PYRUVATEAMINOTRANSFERASE (Pseudomonas sp.) |
PF00202(Aminotran_3) | 5 | ALA A 65GLY A 66ALA A 73ASN A 292LEU A 342 | None | 1.19A | 3rc0A-4uhmA:undetectable | 3rc0A-4uhmA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x6k | ANHYDROSIALIDASE ([Ruminococcus]gnavus) |
PF13088(BNR_2) | 5 | VAL A 417GLY A 419ALA A 473LEU A 384PHE A 458 | None | 1.15A | 3rc0A-4x6kA:undetectable | 3rc0A-4x6kA:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y9l | PROTEIN ACDH-11,ISOFORM B (Caenorhabditiselegans) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M) | 5 | VAL A 249ALA A 250GLY A 205ALA A 254LEU A 185 | None | 1.18A | 3rc0A-4y9lA:0.2 | 3rc0A-4y9lA:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yu5 | IMMUNE INHIBITOR A,METALLOPROTEASE (Bacillus cereus) |
PF05547(Peptidase_M6) | 5 | VAL A 795ALA A 794GLY A 785ALA A 152LEU A 648 | NoneKH2 A1006 (-3.7A)NoneNoneNone | 1.18A | 3rc0A-4yu5A:undetectable | 3rc0A-4yu5A:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bt8 | PHOSPHOGLYCERATEKINASE (Acinetobacterbaumannii) |
PF00162(PGK) | 5 | VAL A 189ALA A 190GLY A 191ALA A 356LEU A 315 | None | 1.14A | 3rc0A-5bt8A:undetectable | 3rc0A-5bt8A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cxw | PENICILLIN-BINDINGPROTEIN 1A (Mycobacteriumtuberculosis) |
PF00905(Transpeptidase) | 5 | VAL A 569ALA A 554GLY A 588ALA A 584LEU A 301 | NoneNone35P A 702 ( 4.1A)NoneNone | 1.26A | 3rc0A-5cxwA:undetectable | 3rc0A-5cxwA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5evy | SALICYLATEHYDROXYLASE (Pseudomonasputida) |
PF01494(FAD_binding_3) | 5 | ALA X 16GLY X 328ALA X 308TYR X 356LEU X 34 | FAD X 501 (-2.8A)NoneNoneNoneNone | 1.18A | 3rc0A-5evyX:undetectable | 3rc0A-5evyX:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fl7 | ATP SYNTHASE SUBUNITALPHA (Yarrowialipolytica) |
PF00006(ATP-synt_ab)PF00306(ATP-synt_ab_C)PF02874(ATP-synt_ab_N) | 5 | VAL A 412ALA A 413GLY A 414ALA A 404LEU A 515 | None | 1.15A | 3rc0A-5fl7A:undetectable | 3rc0A-5fl7A:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jd4 | LAE6 (unculturedbacterium) |
PF07859(Abhydrolase_3) | 5 | ALA A 162GLY A 163TYR A 86ALA A 122PHE A 218 | BAM A 407 (-3.2A)NoneNoneNoneNone | 1.09A | 3rc0A-5jd4A:undetectable | 3rc0A-5jd4A:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kjm | N-LYSINEMETHYLTRANSFERASESMYD2 (Homo sapiens) |
PF00856(SET)PF01753(zf-MYND) | 5 | GLY A 18ASN A 206TYR A 240TYR A 258PHE A 260 | SAM A 501 ( 4.1A)SAM A 501 (-3.2A)6TM A 502 ( 3.6A)6TM A 502 ( 4.2A)SAM A 501 (-3.6A) | 0.51A | 3rc0A-5kjmA:12.5 | 3rc0A-5kjmA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l9o | DEOXYFRUCTOSYL-AMINOACID TRANSPORTERPERIPLASMIC BINDINGPROTEIN (Agrobacteriumfabrum) |
PF00497(SBP_bac_3) | 5 | VAL A 110ALA A 111GLY A 50LEU A 243TYR A 131 | None | 1.04A | 3rc0A-5l9oA:undetectable | 3rc0A-5l9oA:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mdn | DNA POLYMERASE (Pyrobaculumcalidifontis) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 5 | VAL A 534ALA A 531TYR A 439ALA A 523TYR A 517 | None | 1.24A | 3rc0A-5mdnA:undetectable | 3rc0A-5mdnA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mmd | METALLO-BETA-LACTAMASE 1 (Acinetobacterbaumannii) |
PF00753(Lactamase_B) | 5 | VAL E 260GLY E 264TYR E 58ASN E 70LEU E 72 | None | 1.18A | 3rc0A-5mmdE:undetectable | 3rc0A-5mmdE:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tuy | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A1049TYR A1085ASN A1112LEU A1114TYR A1154 | SAM A1505 ( 3.9A)SAM A1505 (-4.0A)SAM A1505 (-3.4A)NoneSAM A1505 (-4.9A) | 1.07A | 3rc0A-5tuyA:6.6 | 3rc0A-5tuyA:18.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vys | GDP-MANNOSE4,6-DEHYDRATASE /GDP-4-AMINO-4,6-DIDEOXY-D-MANNOSEFORMYLTRANSFERASE (Brucellamelitensis) |
PF00551(Formyl_trans_N) | 5 | VAL A 11GLY A 13TYR A 14ALA A 172LEU A 25 | None | 1.12A | 3rc0A-5vysA:undetectable | 3rc0A-5vysA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7f | PUTATIVEO-METHYLTRANSFERASERV1220C (Mycobacteriumtuberculosis) |
PF01596(Methyltransf_3) | 5 | VAL A 42ALA A 41GLY A 40ALA A 99LEU A 50 | SAM A 301 (-3.5A)SAM A 301 (-4.2A)SAM A 301 (-3.8A)NoneNone | 1.13A | 3rc0A-5x7fA:undetectable | 3rc0A-5x7fA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xxg | - (-) |
no annotation | 5 | GLY A 15ASN A 205TYR A 239TYR A 257PHE A 259 | SAM A 502 ( 3.9A)SAM A 502 (-3.1A)8HR A 501 ( 4.0A)NoneSAM A 502 (-3.5A) | 0.41A | 3rc0A-5xxgA:12.3 | 3rc0A-5xxgA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ydj | ACETYLCHOLINESTERASE (Anophelesgambiae) |
no annotation | 5 | ALA A 328GLY A 329TYR A 309ALA A 197TYR A 196 | None | 1.20A | 3rc0A-5ydjA:undetectable | 3rc0A-5ydjA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6byw | GOXA (Pseudoalteromonasluteoviolacea) |
no annotation | 5 | VAL B 331ALA B 352ALA B 566LEU B 295TYR B 154 | None | 1.07A | 3rc0A-6bywB:undetectable | 3rc0A-6bywB:undetectable |