SIMILAR PATTERNS OF AMINO ACIDS FOR 3RC0_A_SAMA484_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9e PROTOHEME FERROLYASE

(Bacillus
subtilis)
PF00762
(Ferrochelatase)
5 VAL A  10
GLY A  85
ALA A  57
TYR A  17
LEU A  67
None
1.23A 3rc0A-1c9eA:
undetectable
3rc0A-1c9eA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius)
PF07859
(Abhydrolase_3)
5 ALA A 156
GLY A 157
TYR A  80
ALA A 116
PHE A 214
EPE  A 455 (-3.8A)
None
None
None
EPE  A 455 (-4.8A)
1.15A 3rc0A-1evqA:
undetectable
3rc0A-1evqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdr FLAVODOXIN REDUCTASE

(Escherichia
coli)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 ALA A 117
GLY A 213
ALA A  51
LEU A  19
TYR A  52
None
None
FAD  A 249 (-3.8A)
None
FAD  A 249 (-4.4A)
1.21A 3rc0A-1fdrA:
0.0
3rc0A-1fdrA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3


(Rattus
norvegicus)
PF00248
(Aldo_ket_red)
5 VAL A 281
ALA A 280
TYR A 107
TYR A 164
PHE A 190
None
1.15A 3rc0A-1gveA:
undetectable
3rc0A-1gveA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa)
PF00135
(COesterase)
5 ALA A 210
GLY A 122
ALA A 159
LEU A 302
TYR A 306
None
1.25A 3rc0A-1gz7A:
0.0
3rc0A-1gz7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg3 TRIOSEPHOSPHATE
ISOMERASE


(Pyrococcus
woesei)
PF00121
(TIM)
PF05690
(ThiG)
5 VAL A  90
ALA A  89
GLY A  88
ALA A  28
LEU A   4
None
1.23A 3rc0A-1hg3A:
undetectable
3rc0A-1hg3A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus)
PF07859
(Abhydrolase_3)
5 ALA A 161
GLY A 162
TYR A  85
ALA A 121
PHE A 218
EPE  A 455 (-3.4A)
None
None
None
EPE  A 455 ( 4.9A)
1.19A 3rc0A-1jjiA:
undetectable
3rc0A-1jjiA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5q PROTEASOME BETA-TYPE
SUBUNIT 1


(Rhodococcus
erythropolis)
PF00227
(Proteasome)
5 VAL H   4
ALA H  15
GLY H  16
ALA H 214
LEU H 150
None
1.19A 3rc0A-1q5qH:
undetectable
3rc0A-1q5qH:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5r PROTEASOME BETA-TYPE
SUBUNIT 1


(Rhodococcus
erythropolis)
PF00227
(Proteasome)
5 VAL H   4
ALA H  15
GLY H  16
ALA H 214
LEU H 150
None
1.23A 3rc0A-1q5rH:
undetectable
3rc0A-1q5rH:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE


(Vibrio
proteolyticus)
PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36)
5 ALA A 469
GLY A 381
TYR A 382
ALA A 352
LEU A 512
None
1.15A 3rc0A-1v7vA:
undetectable
3rc0A-1v7vA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcg THIOGLUCOSIDASE

(Brevicoryne
brassicae)
PF00232
(Glyco_hydro_1)
5 VAL A 136
ALA A 194
GLY A 195
LEU A 184
TYR A 180
None
1.22A 3rc0A-1wcgA:
undetectable
3rc0A-1wcgA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Pyrococcus
furiosus)
PF00290
(Trp_syntA)
5 VAL A 200
GLY A 220
TYR A  10
ALA A  32
LEU A 209
None
1.24A 3rc0A-1wdwA:
undetectable
3rc0A-1wdwA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bhm TYPE IV SECRETION
SYSTEM PROTEIN VIRB8


(Brucella suis)
PF04335
(VirB8)
5 VAL A 163
TYR A 117
TYR A 141
TYR A 229
TYR A 110
None
1.16A 3rc0A-2bhmA:
undetectable
3rc0A-2bhmA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2


(Homo sapiens)
PF00248
(Aldo_ket_red)
5 VAL A 314
ALA A 313
TYR A 140
TYR A 197
PHE A 223
None
1.18A 3rc0A-2bp1A:
undetectable
3rc0A-2bp1A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon)
PF07859
(Abhydrolase_3)
5 ALA A 155
GLY A 156
TYR A  79
ALA A 115
PHE A 214
None
1.21A 3rc0A-2c7bA:
undetectable
3rc0A-2c7bA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c91 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2


(Mus musculus)
PF00248
(Aldo_ket_red)
5 VAL A 281
ALA A 280
TYR A 107
TYR A 164
PHE A 190
None
1.14A 3rc0A-2c91A:
undetectable
3rc0A-2c91A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cc3 PROTEIN VIRB8

(Agrobacterium
tumefaciens)
PF04335
(VirB8)
5 VAL A 160
TYR A 112
TYR A 136
TYR A 222
TYR A 105
None
1.25A 3rc0A-2cc3A:
undetectable
3rc0A-2cc3A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3


(Homo sapiens)
PF00248
(Aldo_ket_red)
5 VAL A 314
ALA A 313
TYR A 140
TYR A 197
PHE A 223
None
1.14A 3rc0A-2clpA:
undetectable
3rc0A-2clpA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE


(Manduca sexta)
PF00135
(COesterase)
5 ALA A 194
GLY A 195
TYR A 175
ALA A  61
TYR A  60
None
1.13A 3rc0A-2fj0A:
undetectable
3rc0A-2fj0A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE


(Escherichia
coli)
PF00698
(Acyl_transf_1)
5 ALA A   5
ALA A 102
LEU A 297
TYR A  74
PHE A   8
None
1.21A 3rc0A-2g2oA:
undetectable
3rc0A-2g2oA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E


(Pisum sativum)
PF00856
(SET)
PF09273
(Rubis-subs-bind)
5 GLY A  81
ASN A 242
TYR A 287
TYR A 300
PHE A 302
SAM  A 801 (-3.7A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
0.53A 3rc0A-2h21A:
29.4
3rc0A-2h21A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2


(Homo sapiens)
PF00248
(Aldo_ket_red)
5 GLY A  62
ALA A  24
LEU A  40
TYR A 272
PHE A  21
None
NAP  A   1 (-3.3A)
None
None
None
1.18A 3rc0A-2ipjA:
undetectable
3rc0A-2ipjA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE


(Homo sapiens)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
5 VAL A 136
ALA A 159
GLY A 158
ALA A 278
LEU A 258
None
1.15A 3rc0A-2jbmA:
undetectable
3rc0A-2jbmA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3i HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum)
PF06032
(DUF917)
5 VAL A 138
ALA A 137
GLY A  24
ALA A 229
LEU A 364
None
1.25A 3rc0A-2o3iA:
undetectable
3rc0A-2o3iA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2of5 LEUCINE-RICH REPEAT
AND DEATH
DOMAIN-CONTAINING
PROTEIN


(Homo sapiens)
PF00531
(Death)
5 VAL H 795
ALA H 796
GLY H 797
LEU H 787
PHE H 837
None
1.04A 3rc0A-2of5H:
undetectable
3rc0A-2of5H:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU


(Escherichia
coli)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
5 VAL A 344
ALA A 361
GLY A 362
LEU A 332
TYR A 366
None
1.26A 3rc0A-2oi6A:
undetectable
3rc0A-2oi6A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooc HISTIDINE
PHOSPHOTRANSFERASE


(Caulobacter
vibrioides)
PF01627
(Hpt)
5 VAL A  65
ALA A  62
GLY A  60
ALA A  41
LEU A  30
None
1.10A 3rc0A-2oocA:
undetectable
3rc0A-2oocA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkn PROTEIN SSU81

(Saccharomyces
cerevisiae)
PF00018
(SH3_1)
5 VAL A  33
ALA A  43
ALA A  15
TYR A  13
PHE A  25
None
0.94A 3rc0A-2vknA:
undetectable
3rc0A-2vknA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w38 SIALIDASE

(Pseudomonas
aeruginosa)
PF13088
(BNR_2)
5 ALA A 323
TYR A 297
ASN A 311
LEU A  11
TYR A  36
None
1.26A 3rc0A-2w38A:
undetectable
3rc0A-2w38A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN


(Streptococcus
pneumoniae)
PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3)
5 VAL A 298
LEU A 281
TYR A 234
TYR A 324
PHE A 322
None
1.25A 3rc0A-2x9xA:
undetectable
3rc0A-2x9xA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9z CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN


(Streptococcus
pneumoniae)
PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3)
5 VAL A 298
LEU A 281
TYR A 234
TYR A 324
PHE A 322
None
1.21A 3rc0A-2x9zA:
undetectable
3rc0A-2x9zA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT


(Desulfomicrobium
norvegicum;
Desulfomicrobium
norvegicum)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF12838
(Fer4_7)
5 VAL A 102
ALA A 103
ALA B  26
LEU A 118
TYR A 110
None
1.19A 3rc0A-2xsjA:
undetectable
3rc0A-2xsjA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis)
PF07859
(Abhydrolase_3)
5 ALA A 158
GLY A 159
TYR A  82
ALA A 118
PHE A 217
None
1.12A 3rc0A-2yh2A:
undetectable
3rc0A-2yh2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE


(Photobacterium
sp. JT-ISH-224)
PF11477
(PM0188)
5 GLY A 233
LEU A 304
TYR A 280
TYR A 290
PHE A 292
GOL  A3004 (-3.3A)
None
None
None
None
1.16A 3rc0A-2z4tA:
undetectable
3rc0A-2z4tA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zal L-ASPARAGINASE

(Escherichia
coli)
PF01112
(Asparaginase_2)
5 VAL A  73
ALA A  72
GLY A  71
ALA A  84
ASN A  67
None
None
NA  A 800 ( 4.4A)
None
None
1.18A 3rc0A-2zalA:
undetectable
3rc0A-2zalA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE


(Bifidobacterium
breve)
PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N)
5 GLY A 216
TYR A 217
ALA A 249
LEU A  71
PHE A 296
None
1.24A 3rc0A-3ahiA:
undetectable
3rc0A-3ahiA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE


(Sulfurisphaera
tokodaii)
PF07859
(Abhydrolase_3)
5 ALA A 151
GLY A 152
TYR A  76
ALA A 112
PHE A 206
DEP  A 304 (-3.5A)
None
None
None
DEP  A 304 (-4.5A)
1.16A 3rc0A-3ailA:
undetectable
3rc0A-3ailA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3baz HYDROXYPHENYLPYRUVAT
E REDUCTASE


(Plectranthus
scutellarioides)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 VAL A 201
ALA A 202
GLY A 151
ALA A 163
LEU A 227
None
None
NAP  A 500 (-3.5A)
None
None
1.21A 3rc0A-3bazA:
undetectable
3rc0A-3bazA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c17 L-ASPARAGINASE
PRECURSOR


(Escherichia
coli)
PF01112
(Asparaginase_2)
5 VAL A  73
ALA A  72
GLY A  71
ALA A  84
ASN A  67
None
None
NA  A   1 ( 4.4A)
None
None
1.14A 3rc0A-3c17A:
undetectable
3rc0A-3c17A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbk ELASTASE

(Pseudomonas
aeruginosa)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
5 VAL A 272
ALA A 269
GLY A 268
ALA A 213
LEU A 236
None
1.09A 3rc0A-3dbkA:
1.4
3rc0A-3dbkA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ele AMINO TRANSFERASE

([Eubacterium]
rectale)
PF00155
(Aminotran_1_2)
5 VAL A 275
ALA A 278
GLY A 279
ALA A 142
LEU A 240
None
1.15A 3rc0A-3eleA:
undetectable
3rc0A-3eleA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpk FERREDOXIN-NADP
REDUCTASE


(Salmonella
enterica)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 ALA A 117
GLY A 213
ALA A  51
LEU A  19
TYR A  52
None
None
FAD  A 301 (-3.5A)
None
FAD  A 301 (-4.4A)
1.22A 3rc0A-3fpkA:
undetectable
3rc0A-3fpkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus)
PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 VAL A 693
ALA A 696
GLY A 697
ALA A 669
LEU A 643
None
1.11A 3rc0A-3ho8A:
undetectable
3rc0A-3ho8A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe)
PF08389
(Xpo1)
5 VAL T 150
GLY T 155
ALA T 179
LEU T 131
TYR T 120
None
1.26A 3rc0A-3icqT:
undetectable
3rc0A-3icqT:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252


(Thermus
thermophilus)
PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp)
5 ALA A  16
GLY A   7
ALA A  43
LEU A  68
PHE A  45
None
1.16A 3rc0A-3ie1A:
undetectable
3rc0A-3ie1A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kda CFTR INHIBITORY
FACTOR (CIF)


(Pseudomonas
aeruginosa)
no annotation 5 GLY D  92
ALA D  37
TYR D  38
LEU D 110
TYR D  48
None
1.18A 3rc0A-3kdaD:
undetectable
3rc0A-3kdaD:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE


(Thermococcus
kodakarensis)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 ALA A  43
GLY A  44
TYR A  12
ALA A  27
TYR A  91
None
1.06A 3rc0A-3kdnA:
undetectable
3rc0A-3kdnA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II


(Brucella
melitensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 VAL A 193
ALA A 194
GLY A 195
LEU A  91
TYR A 262
None
1.19A 3rc0A-3kzuA:
undetectable
3rc0A-3kzuA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loy COPPER AMINE OXIDASE

(Ogataea angusta)
PF01179
(Cu_amine_oxid)
5 ALA A 310
GLY A 309
LEU A  13
TYR A  66
TYR A  68
None
None
None
GOL  A 636 (-4.2A)
None
1.20A 3rc0A-3loyA:
undetectable
3rc0A-3loyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1


(Mus musculus)
PF00856
(SET)
PF01753
(zf-MYND)
5 GLY A  18
ASN A 205
TYR A 252
TYR A 270
PHE A 272
SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
0.48A 3rc0A-3n71A:
11.8
3rc0A-3n71A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I


(Yersinia pestis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 VAL A 239
ALA A 188
GLY A 189
ALA A 398
LEU A 348
None
1.21A 3rc0A-3oytA:
undetectable
3rc0A-3oytA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT


(Cryptococcus
neoformans)
PF00432
(Prenyltrans)
5 VAL B 500
GLY B 332
ALA B 297
ASN B 275
LEU B 279
None
1.23A 3rc0A-3q75B:
undetectable
3rc0A-3q75B:
23.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6


(Homo sapiens)
PF00856
(SET)
PF09273
(Rubis-subs-bind)
11 VAL A  72
ALA A  73
GLY A  74
TYR A  75
ALA A 222
TYR A 223
ASN A 251
LEU A 253
TYR A 285
TYR A 297
PHE A 299
SAM  A 484 (-4.6A)
SAM  A 484 (-3.3A)
SAM  A 484 (-3.4A)
None
SAM  A 484 (-3.5A)
SAM  A 484 (-3.6A)
SAM  A 484 (-3.1A)
None
SAM  A 484 (-4.8A)
None
SAM  A 484 (-3.5A)
0.02A 3rc0A-3rc0A:
61.3
3rc0A-3rc0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 VAL A 119
ALA A 118
GLY A  34
TYR A  33
LEU A  80
None
1.01A 3rc0A-3tqpA:
undetectable
3rc0A-3tqpA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v76 FLAVOPROTEIN

(Sinorhizobium
meliloti)
PF03486
(HI0933_like)
5 VAL A 159
ALA A 160
GLY A  12
ALA A  24
LEU A 363
None
None
FDA  A 547 (-3.4A)
None
None
1.11A 3rc0A-3v76A:
undetectable
3rc0A-3v76A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgl GLUCOKINASE

(Streptomyces
griseus)
PF00480
(ROK)
5 ALA A 152
GLY A 147
ALA A 110
LEU A 250
PHE A 155
None
1.18A 3rc0A-3vglA:
undetectable
3rc0A-3vglA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vns NRPS ADENYLATION
PROTEIN CYTC1


(Streptomyces
sp.)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 TYR A 307
ALA A 330
ASN A 305
LEU A 303
TYR A 325
AMP  A 601 (-4.9A)
None
AMP  A 601 (-3.6A)
None
None
1.19A 3rc0A-3vnsA:
undetectable
3rc0A-3vnsA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9v PHOSPHATE-BINDING
PROTEIN


(unidentified
prokaryotic
organism)
PF12849
(PBP_like_2)
5 VAL A  89
ALA A  90
GLY A 297
ALA A 248
LEU A  13
None
1.19A 3rc0A-3w9vA:
undetectable
3rc0A-3w9vA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waf IRON ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING PROTEIN


(Thermus
thermophilus)
PF13416
(SBP_bac_8)
5 ALA A 250
GLY A 249
ALA A 274
TYR A 268
PHE A 265
None
1.18A 3rc0A-3wafA:
undetectable
3rc0A-3wafA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsb FARNESYLTRANSFERASE,
PUTATIVE


(Trypanosoma
cruzi)
PF00494
(SQS_PSY)
5 VAL A 167
ALA A 168
GLY A 169
ALA A 260
TYR A 160
RWZ  A 502 (-4.3A)
FPS  A 501 (-4.7A)
None
None
None
1.15A 3rc0A-3wsbA:
undetectable
3rc0A-3wsbA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxx AOPB

(Aeromonas
hydrophila)
PF04888
(SseC)
5 VAL B 241
ALA B 240
GLY B 244
ALA B  99
LEU B  86
None
1.25A 3rc0A-3wxxB:
undetectable
3rc0A-3wxxB:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride)
PF01593
(Amino_oxidase)
5 VAL A  17
GLY A  47
TYR A  50
LEU A  81
TYR A  69
FAD  A 601 (-4.4A)
FAD  A 601 (-3.4A)
None
None
FAD  A 601 (-4.3A)
1.12A 3rc0A-3x0vA:
undetectable
3rc0A-3x0vA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8


(Brucella suis)
PF04335
(VirB8)
5 VAL A 163
TYR A 117
TYR A 141
TYR A 229
TYR A 110
None
1.16A 3rc0A-4akzA:
undetectable
3rc0A-4akzA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at0 3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E


(Rhodococcus
jostii)
PF00890
(FAD_binding_2)
5 ALA A  63
GLY A  64
ALA A 292
TYR A 466
PHE A 427
FAD  A1493 (-3.3A)
ACT  A1491 ( 3.2A)
None
ACT  A1490 ( 4.4A)
FAD  A1493 (-4.2A)
1.22A 3rc0A-4at0A:
undetectable
3rc0A-4at0A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bk1 PROBABLE SALICYLATE
MONOOXYGENASE


(Rhodococcus
jostii)
PF01494
(FAD_binding_3)
5 VAL A  44
ALA A  46
GLY A  47
ALA A 229
TYR A 186
None
1.22A 3rc0A-4bk1A:
undetectable
3rc0A-4bk1A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9


(Mus musculus)
PF00856
(SET)
5 ALA A 256
GLY A 257
TYR A 291
ASN A 320
TYR A 357
SAH  A 394 (-3.6A)
SAH  A 394 ( 3.7A)
SAH  A 394 (-3.9A)
SAH  A 394 (-3.4A)
None
0.76A 3rc0A-4c1qA:
5.6
3rc0A-4c1qA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE


(Escherichia
coli)
PF00291
(PALP)
5 VAL A 342
ALA A 341
GLY A 320
TYR A 385
LEU A 289
None
None
None
None
LLP  A  77 (-4.8A)
1.25A 3rc0A-4d9iA:
undetectable
3rc0A-4d9iA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyj RHODOPSIN

(Exiguobacterium
sibiricum)
PF01036
(Bac_rhodopsin)
5 ALA A  64
GLY A  76
LEU A 211
TYR A  58
PHE A  15
None
1.24A 3rc0A-4hyjA:
undetectable
3rc0A-4hyjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE


(Sus scrofa)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
5 VAL A 134
ALA A 157
GLY A 156
ALA A 276
LEU A 256
None
1.14A 3rc0A-4i9aA:
undetectable
3rc0A-4i9aA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Pseudomonas
aeruginosa)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 VAL A  86
ALA A  85
GLY A  10
ALA A 174
LEU A 151
None
1.20A 3rc0A-4jb6A:
undetectable
3rc0A-4jb6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz2 SUPEROXIDE DISMUTASE

(Clostridioides
difficile)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
5 VAL A 101
ALA A 105
GLY A 106
LEU A  78
PHE A  32
None
1.18A 3rc0A-4jz2A:
undetectable
3rc0A-4jz2A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 VAL A3299
ALA A3252
GLY A3253
ALA A3485
LEU A3418
None
1.26A 3rc0A-4kc5A:
undetectable
3rc0A-4kc5A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 VAL A 332
ALA A 331
GLY A 330
TYR A 329
LEU A 345
None
1.15A 3rc0A-4m7eA:
undetectable
3rc0A-4m7eA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT


(Desulfovibrio
salexigens)
PF03480
(DctP)
5 GLY A 243
TYR A 149
ALA A  76
TYR A  77
PHE A  98
None
None
None
X3X  A 401 (-4.5A)
X3X  A 401 (-4.5A)
1.23A 3rc0A-4n6kA:
0.1
3rc0A-4n6kA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6q HASAP

(Pseudomonas
aeruginosa)
PF06438
(HasA)
5 GLY A 139
TYR A 138
ALA A  57
TYR A  56
LEU A 119
None
HEM  A 202 (-3.6A)
None
HEM  A 202 ( 3.7A)
None
1.21A 3rc0A-4o6qA:
undetectable
3rc0A-4o6qA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfw ACYL-COA
THIOESTERASE II


(Yersinia pestis)
PF13622
(4HBT_3)
5 GLY A  37
ALA A  46
TYR A  76
LEU A   9
TYR A  45
None
1.14A 3rc0A-4qfwA:
undetectable
3rc0A-4qfwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE


(Mycolicibacterium
smegmatis)
PF04127
(DFP)
5 VAL A 190
ALA A 230
GLY A 229
ALA A 398
LEU A 409
None
1.06A 3rc0A-4qjiA:
undetectable
3rc0A-4qjiA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE


(Streptomyces
platensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 VAL A2781
ALA A2735
GLY A2736
ALA A2968
LEU A2905
None
1.18A 3rc0A-4qyrA:
undetectable
3rc0A-4qyrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r84 SIALYLTRANSFERASE
0160


(Photobacterium
damselae)
PF11477
(PM0188)
5 GLY A 230
LEU A 300
TYR A 276
TYR A 286
PHE A 288
None
1.05A 3rc0A-4r84A:
undetectable
3rc0A-4r84A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9v SIALYLTRANSFERASE
0160


(Photobacterium
damselae)
PF11477
(PM0188)
5 GLY A 230
LEU A 300
TYR A 276
TYR A 286
PHE A 288
None
1.07A 3rc0A-4r9vA:
undetectable
3rc0A-4r9vA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnh MOTILITY REGULATOR

(Pseudomonas
aeruginosa)
PF00563
(EAL)
PF00990
(GGDEF)
5 TYR A1143
ALA A1078
ASN A1148
LEU A1152
PHE A1140
None
1.13A 3rc0A-4rnhA:
undetectable
3rc0A-4rnhA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE


(Pseudomonas sp.)
PF00202
(Aminotran_3)
5 ALA A  65
GLY A  66
ALA A  73
ASN A 292
LEU A 342
None
1.19A 3rc0A-4uhmA:
undetectable
3rc0A-4uhmA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x6k ANHYDROSIALIDASE

([Ruminococcus]
gnavus)
PF13088
(BNR_2)
5 VAL A 417
GLY A 419
ALA A 473
LEU A 384
PHE A 458
None
1.15A 3rc0A-4x6kA:
undetectable
3rc0A-4x6kA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B


(Caenorhabditis
elegans)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
5 VAL A 249
ALA A 250
GLY A 205
ALA A 254
LEU A 185
None
1.18A 3rc0A-4y9lA:
0.2
3rc0A-4y9lA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE


(Bacillus cereus)
PF05547
(Peptidase_M6)
5 VAL A 795
ALA A 794
GLY A 785
ALA A 152
LEU A 648
None
KH2  A1006 (-3.7A)
None
None
None
1.18A 3rc0A-4yu5A:
undetectable
3rc0A-4yu5A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt8 PHOSPHOGLYCERATE
KINASE


(Acinetobacter
baumannii)
PF00162
(PGK)
5 VAL A 189
ALA A 190
GLY A 191
ALA A 356
LEU A 315
None
1.14A 3rc0A-5bt8A:
undetectable
3rc0A-5bt8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxw PENICILLIN-BINDING
PROTEIN 1A


(Mycobacterium
tuberculosis)
PF00905
(Transpeptidase)
5 VAL A 569
ALA A 554
GLY A 588
ALA A 584
LEU A 301
None
None
35P  A 702 ( 4.1A)
None
None
1.26A 3rc0A-5cxwA:
undetectable
3rc0A-5cxwA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE


(Pseudomonas
putida)
PF01494
(FAD_binding_3)
5 ALA X  16
GLY X 328
ALA X 308
TYR X 356
LEU X  34
FAD  X 501 (-2.8A)
None
None
None
None
1.18A 3rc0A-5evyX:
undetectable
3rc0A-5evyX:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
ALPHA


(Yarrowia
lipolytica)
PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
5 VAL A 412
ALA A 413
GLY A 414
ALA A 404
LEU A 515
None
1.15A 3rc0A-5fl7A:
undetectable
3rc0A-5fl7A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium)
PF07859
(Abhydrolase_3)
5 ALA A 162
GLY A 163
TYR A  86
ALA A 122
PHE A 218
BAM  A 407 (-3.2A)
None
None
None
None
1.09A 3rc0A-5jd4A:
undetectable
3rc0A-5jd4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2


(Homo sapiens)
PF00856
(SET)
PF01753
(zf-MYND)
5 GLY A  18
ASN A 206
TYR A 240
TYR A 258
PHE A 260
SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
0.51A 3rc0A-5kjmA:
12.5
3rc0A-5kjmA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9o DEOXYFRUCTOSYL-AMINO
ACID TRANSPORTER
PERIPLASMIC BINDING
PROTEIN


(Agrobacterium
fabrum)
PF00497
(SBP_bac_3)
5 VAL A 110
ALA A 111
GLY A  50
LEU A 243
TYR A 131
None
1.04A 3rc0A-5l9oA:
undetectable
3rc0A-5l9oA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
5 VAL A 534
ALA A 531
TYR A 439
ALA A 523
TYR A 517
None
1.24A 3rc0A-5mdnA:
undetectable
3rc0A-5mdnA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmd METALLO-BETA-LACTAMA
SE 1


(Acinetobacter
baumannii)
PF00753
(Lactamase_B)
5 VAL E 260
GLY E 264
TYR E  58
ASN E  70
LEU E  72
None
1.18A 3rc0A-5mmdE:
undetectable
3rc0A-5mmdE:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2


(Homo sapiens)
PF00856
(SET)
PF05033
(Pre-SET)
5 GLY A1049
TYR A1085
ASN A1112
LEU A1114
TYR A1154
SAM  A1505 ( 3.9A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
None
SAM  A1505 (-4.9A)
1.07A 3rc0A-5tuyA:
6.6
3rc0A-5tuyA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE


(Brucella
melitensis)
PF00551
(Formyl_trans_N)
5 VAL A  11
GLY A  13
TYR A  14
ALA A 172
LEU A  25
None
1.12A 3rc0A-5vysA:
undetectable
3rc0A-5vysA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C


(Mycobacterium
tuberculosis)
PF01596
(Methyltransf_3)
5 VAL A  42
ALA A  41
GLY A  40
ALA A  99
LEU A  50
SAM  A 301 (-3.5A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.8A)
None
None
1.13A 3rc0A-5x7fA:
undetectable
3rc0A-5x7fA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxg -

(-)
no annotation 5 GLY A  15
ASN A 205
TYR A 239
TYR A 257
PHE A 259
SAM  A 502 ( 3.9A)
SAM  A 502 (-3.1A)
8HR  A 501 ( 4.0A)
None
SAM  A 502 (-3.5A)
0.41A 3rc0A-5xxgA:
12.3
3rc0A-5xxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae)
no annotation 5 ALA A 328
GLY A 329
TYR A 309
ALA A 197
TYR A 196
None
1.20A 3rc0A-5ydjA:
undetectable
3rc0A-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea)
no annotation 5 VAL B 331
ALA B 352
ALA B 566
LEU B 295
TYR B 154
None
1.07A 3rc0A-6bywB:
undetectable
3rc0A-6bywB:
undetectable