SIMILAR PATTERNS OF AMINO ACIDS FOR 3RAV_A_RAVA183

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad0 ANTIBODY A5B7 (HEAVY
CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B  48
SER B  60
TYR B  59
ALA B  61
 None
 0.99A 3ravA-1ad0B:
undetectable		 3ravA-1ad0B:
19.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bg7 FERRITIN

(Rana
catesbeiana) 		PF00210
(Ferritin) 		4 LEU A  24
SER A  27
TYR A  28
ARG A  59
 None
 0.39A 3ravA-1bg7A:
23.9		 3ravA-1bg7A:
58.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli) 		PF00328
(His_Phos_2) 		4 LEU A  58
TYR A  57
ALA A  99
LEU A 366
 None
 1.08A 3ravA-1dkpA:
undetectable		 3ravA-1dkpA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 SER A 263
ALA A 264
ARG A 260
LEU A 325
 None
None
PGO  A1340 (-4.3A)
None
 0.85A 3ravA-1ex0A:
undetectable		 3ravA-1ex0A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fl5 ANTIBODY GERMLINE
PRECURSOR TO
ANTIBODY 28B4

(Homo sapiens) 		no annotation 4 LEU H  48
SER H  60
TYR H  59
ALA H  61
 None
 1.02A 3ravA-1fl5H:
undetectable		 3ravA-1fl5H:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1h PRECORRIN-8X
METHYLMUTASE

(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		PF02570
(CbiC) 		4 LEU A 176
SER A 172
ALA A 169
LEU A 146
 None
 1.03A 3ravA-1i1hA:
undetectable		 3ravA-1i1hA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		4 LEU A 240
SER A 239
ARG A 207
LEU A 244
 None
 1.01A 3ravA-1ktnA:
undetectable		 3ravA-1ktnA:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lb3 FERRITIN LIGHT CHAIN
1

(Mus musculus) 		PF00210
(Ferritin) 		5 LEU A  28
SER A  31
TYR A  32
ALA A  59
ARG A  63
 None
 0.22A 3ravA-1lb3A:
29.3		 3ravA-1lb3A:
81.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 LEU A 559
SER A 562
TYR A 563
LEU A 555
 None
 0.81A 3ravA-1ldjA:
2.3		 3ravA-1ldjA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lki LEUKEMIA INHIBITORY
FACTOR

(Mus musculus) 		PF01291
(LIF_OSM) 		4 LEU A  40
SER A  43
TYR A  44
LEU A 166
 None
 0.85A 3ravA-1lkiA:
4.9		 3ravA-1lkiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mam IGG2B-KAPPA YST9.1
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  48
SER H  63
TYR H  62
ALA H  64
 None
 1.02A 3ravA-1mamH:
undetectable		 3ravA-1mamH:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 LEU A 352
SER A 220
ALA A 221
ARG A 217
 None
None
CA  A 703 (-4.5A)
None
 1.03A 3ravA-1nugA:
undetectable		 3ravA-1nugA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 LEU A 352
SER A 220
ALA A 221
LEU A 283
 None
None
CA  A 703 (-4.5A)
None
 1.00A 3ravA-1nugA:
undetectable		 3ravA-1nugA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oro OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF00156
(Pribosyltran) 		4 LEU A  57
TYR A  53
ALA A  84
LEU A 151
 None
 1.05A 3ravA-1oroA:
undetectable		 3ravA-1oroA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Methanopyrus
kandleri) 		PF02289
(MCH) 		4 LEU A 189
TYR A 190
ALA A 285
LEU A  90
 None
 0.87A 3ravA-1qlmA:
undetectable		 3ravA-1qlmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvb BETA-GLYCOSIDASE

(Thermosphaera
aggregans) 		PF00232
(Glyco_hydro_1) 		4 LEU A 374
TYR A 375
ARG A 377
LEU A 382
 None
 0.97A 3ravA-1qvbA:
undetectable		 3ravA-1qvbA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		4 LEU A 135
SER A 138
TYR A 139
LEU A  57
 None
 0.95A 3ravA-1r4pA:
undetectable		 3ravA-1r4pA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpt PROSTATIC ACID
PHOSPHATASE

(Rattus
norvegicus) 		PF00328
(His_Phos_2) 		4 LEU A 251
ALA A 248
ARG A 249
LEU A  61
 None
 1.04A 3ravA-1rptA:
undetectable		 3ravA-1rptA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxd GA REPEAT BINDING
PROTEIN, ALPHA

(Mus musculus) 		PF02198
(SAM_PNT) 		5 LEU A 247
TYR A 250
ALA A 253
ARG A 248
LEU A 170
 None
 1.27A 3ravA-1sxdA:
undetectable		 3ravA-1sxdA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t06 HYPOTHETICAL PROTEIN

(Bacillus cereus) 		PF08713
(DNA_alkylation) 		4 LEU A 123
SER A 126
ALA A 170
ARG A 166
 None
 0.94A 3ravA-1t06A:
undetectable		 3ravA-1t06A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1u CHOLINE
O-ACETYLTRANSFERASE

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		4 LEU A 431
TYR A 435
ALA A 602
LEU A 547
 None
 1.08A 3ravA-1t1uA:
undetectable		 3ravA-1t1uA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT

(Salmonella
enterica) 		PF01791
(DeoC) 		5 LEU A  19
SER A  57
TYR A  59
ALA A  81
LEU A 277
 None
 1.16A 3ravA-1to3A:
undetectable		 3ravA-1to3A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwi SKD1 PROTEIN

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 LEU A 300
SER A 337
TYR A 336
ALA A 339
 None
 1.07A 3ravA-1xwiA:
undetectable		 3ravA-1xwiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx1 HYPOTHETICAL PROTEIN
PA2260

(Pseudomonas
aeruginosa) 		PF01261
(AP_endonuc_2) 		4 LEU A  30
SER A   7
ALA A 226
LEU A  63
 None
 1.07A 3ravA-1yx1A:
undetectable		 3ravA-1yx1A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9u UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Homo sapiens) 		PF08969
(USP8_dimer) 		4 TYR A  60
ALA A  47
ARG A  51
LEU A 109
 None
 0.82A 3ravA-2a9uA:
3.3		 3ravA-2a9uA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeq FAB HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 LEU H  48
SER H  63
TYR H  62
ALA H  64
 None
 0.99A 3ravA-2aeqH:
undetectable		 3ravA-2aeqH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		4 LEU A 119
SER A 122
ARG A 152
LEU A  73
 None
 0.94A 3ravA-2b25A:
undetectable		 3ravA-2b25A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon) 		PF07859
(Abhydrolase_3) 		4 LEU A 259
TYR A 260
ALA A 273
LEU A 233
 None
 0.90A 3ravA-2c7bA:
undetectable		 3ravA-2c7bA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfz SDS HYDROLASE SDSA1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 LEU A 510
TYR A 514
ALA A 490
LEU A 227
 None
 0.74A 3ravA-2cfzA:
undetectable		 3ravA-2cfzA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		4 LEU A  72
SER A  75
ALA A 108
LEU A 178
 None
 0.96A 3ravA-2dh4A:
2.3		 3ravA-2dh4A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dld D-LACTATE
DEHYDROGENASE

(Lactobacillus
helveticus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A  66
TYR A  58
ALA A  89
LEU A  36
 None
 0.72A 3ravA-2dldA:
undetectable		 3ravA-2dldA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1n PEX

(Synechococcus
elongatus) 		PF03551
(PadR) 		4 LEU A  44
TYR A  48
ALA A 125
LEU A  40
 None
 0.95A 3ravA-2e1nA:
undetectable		 3ravA-2e1nA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiy PROTEIN FDHE HOMOLOG

(Pseudomonas
aeruginosa) 		PF04216
(FdhE) 		4 LEU A 286
SER A 283
ALA A 282
LEU A 239
 None
 1.06A 3ravA-2fiyA:
undetectable		 3ravA-2fiyA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3j HYPOTHETICAL PROTEIN
PA4359

(Pseudomonas
aeruginosa) 		PF04023
(FeoA) 		4 LEU A  68
SER A  16
TYR A  15
LEU A  27
 None
 1.02A 3ravA-2h3jA:
undetectable		 3ravA-2h3jA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hfe KCSA CHANNEL

(Streptomyces
coelicolor) 		no annotation 4 LEU C  41
SER C  44
TYR C  45
ALA C  65
 None
 0.76A 3ravA-2hfeC:
undetectable		 3ravA-2hfeC:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6u ORNITHINE
CARBAMOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A 151
SER A 152
TYR A 153
ALA A 214
LEU A 165
 None
 1.40A 3ravA-2i6uA:
undetectable		 3ravA-2i6uA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgv TAGATOSE-6-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		4 LEU A   5
SER A  56
ALA A  79
LEU A   7
 None
 1.06A 3ravA-2jgvA:
undetectable		 3ravA-2jgvA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6n UNCHARACTERIZED
PROTEIN
YP_001092504.1

(Shewanella
loihica) 		PF06155
(DUF971) 		5 SER A  44
TYR A  43
ALA A  47
ARG A  41
LEU A  98
 None
 1.15A 3ravA-2l6nA:
undetectable		 3ravA-2l6nA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lm0 AF4/FMR2 FAMILY
MEMBER 1/PROTEIN
AF-9 CHIMERA

(Homo sapiens) 		PF05110
(AF-4) 		4 LEU A 770
SER A 771
ARG A 772
LEU A 767
 None
 1.02A 3ravA-2lm0A:
undetectable		 3ravA-2lm0A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mjf PROTEIN HIT1
RIBOSOME ASSEMBLY 1
PROTEIN

(Saccharomyces
cerevisiae) 		no annotation 4 LEU B  73
TYR B  77
ALA B 101
LEU A  25
 None
 0.65A 3ravA-2mjfB:
undetectable		 3ravA-2mjfB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2no5 (S)-2-HALOACID
DEHALOGENASE IVA

(Burkholderia
cepacia) 		PF13419
(HAD_2) 		4 LEU A  73
TYR A  76
ARG A  74
LEU A  37
 None
None
SO4  A1002 ( 3.1A)
None
 1.00A 3ravA-2no5A:
undetectable		 3ravA-2no5A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nra PI PROTEIN

(Escherichia
coli) 		PF01051
(Rep_3) 		4 LEU C 174
SER C 171
TYR C 170
LEU C 202
 None
 0.79A 3ravA-2nraC:
undetectable		 3ravA-2nraC:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 LEU A  57
SER A  53
ARG A  56
LEU A  68
 None
 1.07A 3ravA-2optA:
2.7		 3ravA-2optA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozv HYPOTHETICAL PROTEIN
ATU0636

(Agrobacterium
fabrum) 		PF05175
(MTS) 		4 LEU A  35
TYR A 255
ALA A 253
LEU A 214
 None
 0.74A 3ravA-2ozvA:
undetectable		 3ravA-2ozvA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2w CITRATE SYNTHASE

(Thermotoga
maritima) 		PF00285
(Citrate_synt) 		4 LEU A 165
SER A 168
ALA A  37
LEU A 306
 None
 0.76A 3ravA-2p2wA:
undetectable		 3ravA-2p2wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE

(Azospirillum
brasilense) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 135
ALA A  99
ARG A 134
LEU A   3
 None
 1.06A 3ravA-2q5oA:
undetectable		 3ravA-2q5oA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q74 INOSITOL-1-MONOPHOSP
HATASE

(Mycobacterium
tuberculosis) 		PF00459
(Inositol_P) 		4 SER A 146
TYR A 145
ALA A 147
ARG A 161
 None
 0.95A 3ravA-2q74A:
undetectable		 3ravA-2q74A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 LEU A 388
TYR A 393
ALA A 385
ARG A 197
 None
 0.89A 3ravA-2qn0A:
undetectable		 3ravA-2qn0A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgz HEME OXYGENASE 2

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		4 LEU A  74
TYR A  75
ALA A 127
LEU A 109
 None
 0.78A 3ravA-2rgzA:
5.0		 3ravA-2rgzA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0x LAMINA-ASSOCIATED
POLYPEPTIDE 2
ISOFORMS ALPHA/ZETA

(Mus musculus) 		PF11560
(LAP2alpha) 		4 LEU A 568
SER A 571
TYR A 572
ALA A 641
 None
 0.75A 3ravA-2v0xA:
3.4		 3ravA-2v0xA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfv XYLITOL OXIDASE

(Streptomyces
coelicolor) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		4 LEU A  42
SER A  62
ALA A  64
LEU A  60
 SFD  A1418 (-4.4A)
None
None
None
 1.00A 3ravA-2vfvA:
undetectable		 3ravA-2vfvA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 LEU A 372
SER A 392
TYR A 373
ALA A 391
 None
 1.04A 3ravA-2wyaA:
undetectable		 3ravA-2wyaA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA

(Escherichia
coli) 		PF00232
(Glyco_hydro_1) 		4 LEU A 365
TYR A 366
ARG A 368
LEU A 373
 None
 0.78A 3ravA-2xhyA:
undetectable		 3ravA-2xhyA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9e MYOSIN-2

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 LEU X 421
SER X 417
ARG X 418
LEU X 596
 None
 1.07A 3ravA-2y9eX:
2.5		 3ravA-2y9eX:
13.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2za8 FERRITIN LIGHT CHAIN

(Equus caballus) 		PF00210
(Ferritin) 		6 LEU A  25
SER A  28
TYR A  29
ALA A  56
ARG A  60
LEU A  82
 None
 0.60A 3ravA-2za8A:
28.7		 3ravA-2za8A:
99.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfw PEX

(Synechococcus
sp.) 		PF03551
(PadR) 		4 LEU A  44
TYR A  48
ALA A 125
LEU A  40
 None
 1.08A 3ravA-2zfwA:
undetectable		 3ravA-2zfwA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		4 LEU A  16
SER A  19
ARG A  62
LEU A  69
 None
 1.05A 3ravA-2zq5A:
undetectable		 3ravA-2zq5A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adc L-SERYL-TRNA(SEC)
KINASE

(Methanocaldococcus
jannaschii) 		PF08433
(KTI12) 		4 LEU A 244
SER A 247
TYR A 248
LEU A 218
 None
 1.07A 3ravA-3adcA:
undetectable		 3ravA-3adcA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt6 INFLUENZA B
HEMAGGLUTININ (HA)

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		4 SER B  26
TYR B  24
ALA B  33
LEU B 122
 None
 1.07A 3ravA-3bt6B:
2.0		 3ravA-3bt6B:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce9 GLYCEROL
DEHYDROGENASE

(Clostridium
acetobutylicum) 		PF13685
(Fe-ADH_2) 		4 SER A  37
ALA A  65
ARG A  35
LEU A 112
 None
 1.01A 3ravA-3ce9A:
undetectable		 3ravA-3ce9A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPK

(Escherichia
coli) 		PF03934
(T2SSK) 		4 LEU K 291
SER K  44
TYR K  43
ALA K  45
 None
 1.04A 3ravA-3ci0K:
undetectable		 3ravA-3ci0K:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 SER A 221
TYR A 228
ALA A 222
ARG A 218
 None
 1.07A 3ravA-3dlaA:
undetectable		 3ravA-3dlaA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do6 FORMATE--TETRAHYDROF
OLATE LIGASE

(Thermotoga
maritima) 		PF01268
(FTHFS) 		4 LEU A 348
ALA A 488
ARG A 349
LEU A 322
 None
 1.05A 3ravA-3do6A:
undetectable		 3ravA-3do6A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpr PROTEIN VP3

(Rhinovirus A) 		PF00073
(Rhv) 		4 LEU C 209
SER C  69
TYR C  68
LEU C  52
 None
 0.82A 3ravA-3dprC:
undetectable		 3ravA-3dprC:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3duu IG-LIKE PROTEIN

(Mus musculus) 		PF07686
(V-set) 		4 LEU B  48
SER B  60
TYR B  59
ALA B  61
 None
 0.99A 3ravA-3duuB:
undetectable		 3ravA-3duuB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 LEU A  40
SER A1014
TYR A1013
ALA A1015
 None
 0.95A 3ravA-3dy5A:
undetectable		 3ravA-3dy5A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		4 LEU A  44
TYR A  45
ARG A  47
LEU A  10
 None
 0.92A 3ravA-3e53A:
undetectable		 3ravA-3e53A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efc OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR YAET

(Escherichia
coli) 		PF07244
(POTRA) 		4 SER A 148
TYR A 147
ALA A 149
LEU A 247
 None
 0.99A 3ravA-3efcA:
undetectable		 3ravA-3efcA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eff VOLTAGE-GATED
POTASSIUM CHANNEL

(Streptomyces
lividans) 		PF07885
(Ion_trans_2) 		4 LEU K  41
SER K  44
TYR K  45
ALA K  65
 None
 0.91A 3ravA-3effK:
2.1		 3ravA-3effK:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 GAMMA
CHAIN

(Escherichia
coli) 		PF02665
(Nitrate_red_gam) 		4 LEU C 133
ALA C 125
ARG C 202
LEU C 194
 HEM  C 806 ( 4.8A)
None
HEM  C 806 (-3.2A)
None
 0.99A 3ravA-3egwC:
2.3		 3ravA-3egwC:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euh MUKE

(Escherichia
coli) 		PF04288
(MukE) 		4 LEU C  39
SER C  41
ARG C  43
LEU C  84
 None
 1.02A 3ravA-3euhC:
undetectable		 3ravA-3euhC:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcx S-FORMYLGLUTATHIONE
HYDROLASE

(Homo sapiens) 		PF00756
(Esterase) 		4 LEU A 207
SER A 210
TYR A 211
LEU A 160
 None
 1.05A 3ravA-3fcxA:
undetectable		 3ravA-3fcxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frm UNCHARACTERIZED
CONSERVED PROTEIN

(Staphylococcus
epidermidis) 		PF13673
(Acetyltransf_10) 		4 LEU A  27
SER A  36
TYR A  25
ALA A  35
 None
 1.04A 3ravA-3frmA:
undetectable		 3ravA-3frmA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxq LYSR TYPE REGULATOR
OF TSAMBCD

(Comamonas
testosteroni) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 LEU A  19
SER A  18
ARG A  20
LEU A  49
 None
 1.07A 3ravA-3fxqA:
undetectable		 3ravA-3fxqA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i50 MURINE HEAVY CHAIN
(IGG3) OF E53
MONOCLONAL ANTIBODY
FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  48
SER H  60
TYR H  59
ALA H  61
 None
 1.02A 3ravA-3i50H:
undetectable		 3ravA-3i50H:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijs IMMUNOGLOBULIN HEAVY
CHAIN (IGG3)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B  48
SER B  60
TYR B  59
ALA B  61
 None
 0.99A 3ravA-3ijsB:
undetectable		 3ravA-3ijsB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Streptomyces
mobaraensis) 		PF09017
(Transglut_prok) 		4 SER A 218
TYR A 217
ARG A 213
LEU A 193
 None
 0.97A 3ravA-3iu0A:
undetectable		 3ravA-3iu0A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1u BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		4 LEU A 180
TYR A 211
ALA A 150
LEU A 225
 None
 1.08A 3ravA-3k1uA:
undetectable		 3ravA-3k1uA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwl UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 4 LEU A 483
SER A 253
ALA A 254
LEU A 485
 None
 1.05A 3ravA-3kwlA:
undetectable		 3ravA-3kwlA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lca PROTEIN TOM71

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF14559
(TPR_19) 		4 LEU A 368
SER A 371
ALA A 345
LEU A 384
 None
 1.08A 3ravA-3lcaA:
2.2		 3ravA-3lcaA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m94 TRANSLATION
INITIATION FACTOR 4E

(Ascaris suum) 		PF01652
(IF4E) 		4 LEU A 146
TYR A 142
ALA A  95
LEU A 200
 None
 1.02A 3ravA-3m94A:
undetectable		 3ravA-3m94A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3maj DNA PROCESSING CHAIN
A

(Rhodopseudomonas
palustris) 		PF02481
(DNA_processg_A) 		5 LEU A 230
SER A 232
ALA A 256
ARG A 255
LEU A 101
 None
None
None
SO4  A 402 (-2.8A)
None
 1.04A 3ravA-3majA:
undetectable		 3ravA-3majA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE

(Homo sapiens) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 LEU X 229
ALA X 234
ARG X 233
LEU X 248
 None
 1.06A 3ravA-3n5nX:
undetectable		 3ravA-3n5nX:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oit OS07G0271500 PROTEIN

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 LEU A 101
SER A 100
ARG A 271
LEU A 105
 None
 1.06A 3ravA-3oitA:
undetectable		 3ravA-3oitA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pj0 LMO0305 PROTEIN

(Listeria
monocytogenes) 		PF01212
(Beta_elim_lyase) 		4 LEU A  27
SER A 247
ALA A 248
LEU A  31
 None
 1.06A 3ravA-3pj0A:
undetectable		 3ravA-3pj0A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE

(Actinobacillus
pleuropneumoniae) 		no annotation 4 LEU A  98
TYR A  94
ALA A 172
LEU A  32
 None
 0.98A 3ravA-3q3hA:
undetectable		 3ravA-3q3hA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		4 LEU A 394
SER A 397
TYR A 398
LEU A 359
 None
 0.79A 3ravA-3qmlA:
undetectable		 3ravA-3qmlA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv9 PYRUVATE KINASE 2

(Trypanosoma
cruzi) 		PF00224
(PK)
PF02887
(PK_C) 		4 SER A 437
ALA A  21
ARG A 414
LEU A 397
 None
 0.97A 3ravA-3qv9A:
undetectable		 3ravA-3qv9A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suj CERATO-PLATANIN 1

(Moniliophthora
perniciosa) 		PF07249
(Cerato-platanin) 		4 LEU A  84
TYR A  86
ALA A  20
LEU A 118
 None
 0.97A 3ravA-3sujA:
undetectable		 3ravA-3sujA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bradyrhizobium
sp. ORS 278) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 195
ALA A 206
ARG A 209
LEU A 218
 None
 1.05A 3ravA-3toyA:
undetectable		 3ravA-3toyA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  48
SER H  60
TYR H  59
ALA H  61
 None
 1.02A 3ravA-3v0wH:
undetectable		 3ravA-3v0wH:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vre HEMOGLOBIN SUBUNIT
ALPHA

(Mammuthus
primigenius) 		PF00042
(Globin) 		4 LEU A 105
TYR A  24
ALA A  26
LEU A 109
 None
 1.09A 3ravA-3vreA:
undetectable		 3ravA-3vreA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		5 SER A 556
TYR A 555
ALA A 557
ARG A 553
LEU A 596
 None
 1.43A 3ravA-4a0hA:
undetectable		 3ravA-4a0hA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5a NUCLEOSIDE-TRIPHOSPH
ATASE 1

(Toxoplasma
gondii) 		PF01150
(GDA1_CD39) 		4 LEU A 335
SER A 331
ALA A 281
LEU A 389
 None
None
ANP  A 700 (-4.5A)
None
 0.97A 3ravA-4a5aA:
undetectable		 3ravA-4a5aA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bej DYNAMIN 1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 LEU A 624
SER A 627
TYR A 628
ALA A 504
 None
 0.59A 3ravA-4bejA:
2.9		 3ravA-4bejA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di5 5-EPI-ARISTOLOCHENE
SYNTHASE

(Nicotiana
tabacum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 147
TYR A 151
ALA A 108
LEU A 175
 None
 1.07A 3ravA-4di5A:
3.5		 3ravA-4di5A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Campylobacter
jejuni) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 LEU A 279
SER A 282
TYR A 283
ALA A 274
LEU A 309
 None
 1.10A 3ravA-4ehiA:
2.0		 3ravA-4ehiA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 CULLIN-1

(Homo sapiens) 		PF00888
(Cullin) 		4 LEU A 559
SER A 562
TYR A 563
LEU A 555
 None
 0.92A 3ravA-4f52A:
undetectable		 3ravA-4f52A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		4 LEU W 232
SER W 235
ALA W 100
LEU W 240
 None
 0.96A 3ravA-4f5xW:
undetectable		 3ravA-4f5xW:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0p ACETATE KINASE

(Cryptococcus
neoformans) 		PF00871
(Acetate_kinase) 		4 LEU A 287
SER A 291
ALA A 295
LEU A 245
 None
 1.00A 3ravA-4h0pA:
undetectable		 3ravA-4h0pA:
17.48