SIMILAR PATTERNS OF AMINO ACIDS FOR 3R9X_B_ACTB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rlm PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		4 LYS A 148
GLU A  67
GLN A  47
TYR A 130
 GOL  A 804 ( 4.2A)
None
None
GOL  A 804 (-4.3A)
 1.43A 3r9xB-1rlmA:
3.1		 3r9xB-1rlmA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0q THIOREDOXIN

(Sulfurisphaera
tokodaii) 		PF00085
(Thioredoxin) 		4 LYS A 135
GLU A 140
GLN A  83
TYR A  81
 None
 0.79A 3r9xB-2e0qA:
0.0		 3r9xB-2e0qA:
17.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Aquifex
aeolicus) 		PF00398
(RrnaAD) 		4 LYS B 130
GLU B 134
GLN B 137
TYR B 157
 ACT  B 502 (-3.5A)
ACT  B 502 (-4.3A)
ACT  B 502 (-4.2A)
ACT  B 502 (-3.5A)
 0.02A 3r9xB-3r9xB:
40.9		 3r9xB-3r9xB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xax DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA DOMAIN 1
CARD

(Thermus
aquaticus;
Thermus
thermophilus) 		PF04563
(RNA_pol_Rpb2_1)
PF02559
(CarD_CdnL_TRCF) 		4 LYS B  46
GLU A 110
GLN A  99
TYR B  48
 None
 1.24A 3r9xB-4xaxB:
0.0		 3r9xB-4xaxB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8s AMINO ACYL PEPTIDASE

(Sporosarcina
psychrophila) 		PF00326
(Peptidase_S9) 		4 LYS A 128
GLU A 108
GLN A  87
TYR A 110
 None
 1.36A 3r9xB-5l8sA:
4.2		 3r9xB-5l8sA:
19.09