SIMILAR PATTERNS OF AMINO ACIDS FOR 3R9W_A_ACTA506

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxq CHOLINE/ETHANOLAMINE
KINASE FAMILY
PROTEIN

(Mesorhizobium
loti) 		PF01633
(Choline_kinase) 		4 GLU A 214
GLU A 182
ASN A 183
PHE A 184
 None
 1.06A 3r9wA-3dxqA:
0.2		 3r9wA-3dxqA:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r9w GTPASE ERA

(Aquifex
aeolicus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		4 GLU A  64
GLU A 105
ASN A 109
PHE A 110
 ACT  A 506 (-4.0A)
ACT  A 506 ( 4.1A)
ACT  A 506 ( 4.8A)
ACT  A 506 ( 4.9A)
 0.00A 3r9wA-3r9wA:
51.5		 3r9wA-3r9wA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrd UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF16255
(Lipase_GDSL_lke) 		4 GLU A 218
GLU A  73
ASN A  74
PHE A  70
 None
 1.36A 3r9wA-4nrdA:
4.9		 3r9wA-4nrdA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 GLU A  84
GLU A 248
ASN A  77
PHE A 153
 None
 1.33A 3r9wA-4zxlA:
0.8		 3r9wA-4zxlA:
21.02