SIMILAR PATTERNS OF AMINO ACIDS FOR 3R9V_B_DXCB323

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbv GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Geobacillus
stearothermophilus)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
4 LEU O 333
ILE O 144
VAL O 321
LEU O 324
None
0.60A 3r9vA-1dbvO:
0.0
3r9vB-1dbvO:
0.0
3r9vA-1dbvO:
22.69
3r9vB-1dbvO:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3


(Dictyostelium
discoideum)
PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N)
4 LEU A 592
ILE A 347
VAL A 608
LEU A 611
None
0.70A 3r9vA-1g8xA:
0.0
3r9vB-1g8xA:
0.0
3r9vA-1g8xA:
15.67
3r9vB-1g8xA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE


(Escherichia
coli)
PF02374
(ArsA_ATPase)
4 LEU A   4
VAL A 285
LEU A 288
SER A 289
None
0.61A 3r9vA-1ii0A:
0.0
3r9vB-1ii0A:
0.0
3r9vA-1ii0A:
19.30
3r9vB-1ii0A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1muu GDP-MANNOSE
6-DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
4 ILE A   3
ILE A   5
LEU A  19
SER A  20
None
0.69A 3r9vA-1muuA:
undetectable
3r9vB-1muuA:
undetectable
3r9vA-1muuA:
20.75
3r9vB-1muuA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT


(Mus musculus)
PF00514
(Arm)
PF16186
(Arm_3)
4 ILE B 421
VAL B 383
LEU B 386
SER B 387
None
0.65A 3r9vA-1pjmB:
0.9
3r9vB-1pjmB:
undetectable
3r9vA-1pjmB:
19.10
3r9vB-1pjmB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT


(Mus musculus)
PF00514
(Arm)
PF16186
(Arm_3)
4 LEU B 343
ILE B 320
VAL B 295
LEU B 298
None
0.66A 3r9vA-1pjmB:
0.9
3r9vB-1pjmB:
undetectable
3r9vA-1pjmB:
19.10
3r9vB-1pjmB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrm LACTALDEHYDE
REDUCTASE


(Escherichia
coli)
PF00465
(Fe-ADH)
4 ILE A 109
ILE A 110
VAL A 119
LEU A 122
None
0.70A 3r9vA-1rrmA:
0.0
3r9vB-1rrmA:
0.0
3r9vA-1rrmA:
20.65
3r9vB-1rrmA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE


(Solanum
tuberosum)
PF02446
(Glyco_hydro_77)
4 LEU A 514
ILE A 469
LEU A  64
SER A  63
None
0.69A 3r9vA-1x1nA:
undetectable
3r9vB-1x1nA:
undetectable
3r9vA-1x1nA:
20.68
3r9vB-1x1nA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ylf RRF2 FAMILY PROTEIN

(Bacillus cereus)
PF02082
(Rrf2)
4 ILE A  75
VAL A  14
LEU A  17
SER A  18
None
0.68A 3r9vA-1ylfA:
0.0
3r9vB-1ylfA:
0.0
3r9vA-1ylfA:
23.22
3r9vB-1ylfA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE


(Vitis vinifera)
PF00201
(UDPGT)
4 ILE A 276
VAL A 289
LEU A 292
SER A 293
None
0.71A 3r9vA-2c1zA:
undetectable
3r9vB-2c1zA:
0.0
3r9vA-2c1zA:
22.61
3r9vB-2c1zA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE


(Porphyromonas
gingivalis)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
4 ILE A 442
ILE A 444
VAL A  55
LEU A  57
None
0.67A 3r9vA-2d5lA:
undetectable
3r9vB-2d5lA:
undetectable
3r9vA-2d5lA:
17.97
3r9vB-2d5lA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbb PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PH0061


(Pyrococcus
horikoshii)
PF13412
(HTH_24)
4 ILE A  53
VAL A  15
LEU A  18
SER A  19
None
0.69A 3r9vA-2dbbA:
undetectable
3r9vB-2dbbA:
undetectable
3r9vA-2dbbA:
21.72
3r9vB-2dbbA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE


(Candida
tropicalis)
PF00106
(adh_short)
4 ILE A 191
VAL A 221
LEU A 224
SER A 225
None
0.58A 3r9vA-2et6A:
undetectable
3r9vB-2et6A:
undetectable
3r9vA-2et6A:
18.45
3r9vB-2et6A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6e D-ARABINOSE
1-DEHYDROGENASE


(Sulfolobus
solfataricus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ILE A 189
VAL A 303
LEU A 306
SER A 307
None
0.67A 3r9vA-2h6eA:
undetectable
3r9vB-2h6eA:
undetectable
3r9vA-2h6eA:
21.14
3r9vB-2h6eA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2him L-ASPARAGINASE 1

(Escherichia
coli)
PF00710
(Asparaginase)
4 TRP A  68
ILE A  71
ILE A  75
VAL A 112
None
0.59A 3r9vA-2himA:
undetectable
3r9vB-2himA:
undetectable
3r9vA-2himA:
22.31
3r9vB-2himA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE


(Pyrococcus
horikoshii)
PF16363
(GDP_Man_Dehyd)
4 ILE A  33
ILE A  35
VAL A  69
LEU A  72
None
0.70A 3r9vA-2hunA:
undetectable
3r9vB-2hunA:
undetectable
3r9vA-2hunA:
22.32
3r9vB-2hunA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
4 ILE A 327
ILE A 331
VAL A 289
LEU A 292
None
0.66A 3r9vA-2iukA:
undetectable
3r9vB-2iukA:
2.6
3r9vA-2iukA:
16.59
3r9vB-2iukA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2koj PARTITIONING
DEFECTIVE 3 HOMOLOG


(Mus musculus)
PF00595
(PDZ)
4 LEU A 494
ILE A 488
VAL A 528
LEU A 531
None
0.71A 3r9vA-2kojA:
undetectable
3r9vB-2kojA:
undetectable
3r9vA-2kojA:
19.26
3r9vB-2kojA:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p7n PATHOGENICITY ISLAND
1 EFFECTOR PROTEIN


(Chromobacterium
violaceum)
PF06511
(IpaD)
4 ILE A 185
ILE A 189
VAL A 379
LEU A 382
None
0.65A 3r9vA-2p7nA:
12.2
3r9vB-2p7nA:
13.3
3r9vA-2p7nA:
34.77
3r9vB-2p7nA:
34.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph7 UNCHARACTERIZED
PROTEIN AF_2093


(Archaeoglobus
fulgidus)
no annotation 4 ILE A  24
VAL A   6
LEU A   9
SER A  10
None
0.52A 3r9vA-2ph7A:
undetectable
3r9vB-2ph7A:
undetectable
3r9vA-2ph7A:
22.80
3r9vB-2ph7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q50 GLYOXYLATE
REDUCTASE/HYDROXYPYR
UVATE REDUCTASE


(Homo sapiens)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
4 LEU A 151
ILE A 241
ILE A 243
LEU A 118
None
0.67A 3r9vA-2q50A:
undetectable
3r9vB-2q50A:
undetectable
3r9vA-2q50A:
22.02
3r9vB-2q50A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmz INTEGRIN BETA-3

(Homo sapiens)
no annotation 4 LEU A 706
VAL A 695
LEU A 698
SER A 699
None
0.71A 3r9vA-2rmzA:
undetectable
3r9vB-2rmzA:
undetectable
3r9vA-2rmzA:
11.07
3r9vB-2rmzA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1


(Homo sapiens)
PF00069
(Pkinase)
4 LEU A 165
VAL A 154
LEU A 157
SER A 158
None
0.70A 3r9vA-2rsvA:
2.7
3r9vB-2rsvA:
2.0
3r9vA-2rsvA:
19.95
3r9vB-2rsvA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9z G1/S-SPECIFIC
CYCLIN-D1


(Homo sapiens)
PF00134
(Cyclin_N)
PF02984
(Cyclin_C)
4 ILE A 177
ILE A 178
VAL A 212
LEU A 215
None
0.62A 3r9vA-2w9zA:
undetectable
3r9vB-2w9zA:
undetectable
3r9vA-2w9zA:
19.53
3r9vB-2w9zA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xua 3-OXOADIPATE
ENOL-LACTONASE


(Paraburkholderia
xenovorans)
PF12146
(Hydrolase_4)
4 ILE A  29
VAL A  46
LEU A  49
SER A  50
None
0.57A 3r9vA-2xuaA:
undetectable
3r9vB-2xuaA:
undetectable
3r9vA-2xuaA:
22.15
3r9vB-2xuaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbk TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A


(Sulfolobus
shibatae)
PF04406
(TP6A_N)
4 ILE A 229
ILE A 231
VAL A 245
LEU A 248
None
0.50A 3r9vA-2zbkA:
undetectable
3r9vB-2zbkA:
undetectable
3r9vA-2zbkA:
20.96
3r9vB-2zbkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apm PROTEIN-ARGININE
DEIMINASE TYPE-4


(Homo sapiens)
PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M)
4 ILE A 565
ILE A 567
VAL A 616
LEU A 619
None
0.49A 3r9vA-3apmA:
undetectable
3r9vB-3apmA:
undetectable
3r9vA-3apmA:
17.22
3r9vB-3apmA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5e MLL8374 PROTEIN

(Mesorhizobium
japonicum)
no annotation 4 ILE A 162
VAL A 179
LEU A 182
SER A 183
None
0.67A 3r9vA-3b5eA:
undetectable
3r9vB-3b5eA:
undetectable
3r9vA-3b5eA:
21.41
3r9vB-3b5eA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ble CITRAMALATE SYNTHASE
FROM LEPTOSPIRA
INTERROGANS


(Leptospira
interrogans)
PF00682
(HMGL-like)
4 ILE A 171
ILE A 174
VAL A 163
LEU A 166
None
0.68A 3r9vA-3bleA:
undetectable
3r9vB-3bleA:
undetectable
3r9vA-3bleA:
24.45
3r9vB-3bleA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blz NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION


(Shewanella
baltica)
PF12893
(Lumazine_bd_2)
4 ILE A  91
VAL A  14
LEU A  17
SER A  18
None
0.56A 3r9vA-3blzA:
undetectable
3r9vB-3blzA:
undetectable
3r9vA-3blzA:
18.53
3r9vB-3blzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
4 ILE A 816
ILE A 756
VAL A 791
LEU A 796
None
0.68A 3r9vA-3cttA:
undetectable
3r9vB-3cttA:
undetectable
3r9vA-3cttA:
16.09
3r9vB-3cttA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djl PROTEIN AIDB

(Escherichia
coli)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
4 ILE A 318
ILE A 332
LEU A 341
SER A 342
None
0.66A 3r9vA-3djlA:
1.7
3r9vB-3djlA:
1.1
3r9vA-3djlA:
18.62
3r9vB-3djlA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY


(Methanopyrus
kandleri)
PF00493
(MCM)
4 ILE A 121
ILE A 119
VAL A 167
LEU A 172
None
0.70A 3r9vA-3f8tA:
undetectable
3r9vB-3f8tA:
undetectable
3r9vA-3f8tA:
20.04
3r9vB-3f8tA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3geu INTERCELLULAR
ADHESION PROTEIN R


(Staphylococcus
aureus)
PF00440
(TetR_N)
4 ILE A 110
ILE A 114
LEU A  99
SER A 100
None
0.57A 3r9vA-3geuA:
undetectable
3r9vB-3geuA:
undetectable
3r9vA-3geuA:
23.66
3r9vB-3geuA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq2 GENERAL VESICULAR
TRANSPORT FACTOR
P115


(Bos taurus)
PF04869
(Uso1_p115_head)
4 LEU A 146
ILE A 200
ILE A 203
LEU A 162
None
0.72A 3r9vA-3gq2A:
undetectable
3r9vB-3gq2A:
undetectable
3r9vA-3gq2A:
19.45
3r9vB-3gq2A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho6 TOXIN A

(Clostridioides
difficile)
PF11713
(Peptidase_C80)
4 LEU A  19
ILE A  41
ILE A 111
LEU A  57
None
0.67A 3r9vA-3ho6A:
undetectable
3r9vB-3ho6A:
undetectable
3r9vA-3ho6A:
23.57
3r9vB-3ho6A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il3 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Haemophilus
influenzae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 ILE A 249
VAL A 216
LEU A 219
SER A 220
None
0.70A 3r9vA-3il3A:
undetectable
3r9vB-3il3A:
undetectable
3r9vA-3il3A:
22.51
3r9vB-3il3A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S18C,
MITOCHONDRIAL


(Bos taurus)
PF01084
(Ribosomal_S18)
4 ILE R 112
VAL R  78
LEU R  81
SER R  82
None
0.68A 3r9vA-3jd5R:
undetectable
3r9vB-3jd5R:
undetectable
3r9vA-3jd5R:
17.45
3r9vB-3jd5R:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3f PROTEIN DOA1

(Saccharomyces
cerevisiae)
PF08324
(PUL)
PF09070
(PFU)
4 ILE X 599
ILE X 603
VAL X 622
LEU X 625
None
0.68A 3r9vA-3l3fX:
undetectable
3r9vB-3l3fX:
undetectable
3r9vA-3l3fX:
22.31
3r9vB-3l3fX:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkw FUSION PROTEIN OF
NONSTRUCTURAL
PROTEIN 2B AND
NONSTRUCTURAL
PROTEIN 3


(Dengue virus)
PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B)
4 LEU A 126
ILE A 215
ILE A 176
VAL A 147
None
0.70A 3r9vA-3lkwA:
undetectable
3r9vB-3lkwA:
undetectable
3r9vA-3lkwA:
21.92
3r9vB-3lkwA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntx CYTOPLASMIC
L-ASPARAGINASE I


(Yersinia pestis)
PF00710
(Asparaginase)
4 TRP A  68
ILE A  71
ILE A  75
VAL A 112
None
0.61A 3r9vA-3ntxA:
undetectable
3r9vB-3ntxA:
undetectable
3r9vA-3ntxA:
23.76
3r9vB-3ntxA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE


(Campylobacter
jejuni)
PF02784
(Orn_Arg_deC_N)
4 ILE A  34
ILE A  31
VAL A 331
LEU A  49
None
0.67A 3r9vA-3nzpA:
undetectable
3r9vB-3nzpA:
2.7
3r9vA-3nzpA:
18.77
3r9vB-3nzpA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE


(Rubrobacter
xylanophilus)
PF00535
(Glycos_transf_2)
5 ILE A  60
ILE A  61
VAL A  79
LEU A  48
SER A  50
None
0.95A 3r9vA-3o3pA:
undetectable
3r9vB-3o3pA:
undetectable
3r9vA-3o3pA:
20.20
3r9vB-3o3pA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
PROBABLE PROTEIN
BRICK1


(Homo sapiens;
Homo sapiens)
PF02205
(WH2)
no annotation
5 ILE E  64
ILE E  61
VAL D  73
LEU D  76
SER D  77
None
1.33A 3r9vA-3p8cE:
undetectable
3r9vB-3p8cE:
undetectable
3r9vA-3p8cE:
15.02
3r9vB-3p8cE:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0h INACTIVATION-NO-AFTE
R-POTENTIAL D
PROTEIN


(Drosophila
melanogaster)
PF00595
(PDZ)
4 ILE A 541
ILE A 546
VAL A 556
LEU A 559
None
0.61A 3r9vA-3r0hA:
undetectable
3r9vB-3r0hA:
undetectable
3r9vA-3r0hA:
23.16
3r9vB-3r0hA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sg1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1


(Bacillus
anthracis)
PF00275
(EPSP_synthase)
4 ILE A  28
ILE A  29
VAL A  72
LEU A  42
None
0.61A 3r9vA-3sg1A:
undetectable
3r9vB-3sg1A:
undetectable
3r9vA-3sg1A:
20.92
3r9vB-3sg1A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmc UNCHARACTERIZED
PROTEIN


(Bdellovibrio
bacteriovorus)
PF13487
(HD_5)
4 LEU A 165
VAL A 154
LEU A 157
SER A 158
None
0.70A 3r9vA-3tmcA:
undetectable
3r9vB-3tmcA:
undetectable
3r9vA-3tmcA:
22.29
3r9vB-3tmcA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB


(Bacillus
anthracis)
PF04183
(IucA_IucC)
PF06276
(FhuF)
4 ILE A 419
ILE A 423
VAL A 505
LEU A 509
None
0.63A 3r9vA-3to3A:
undetectable
3r9vB-3to3A:
undetectable
3r9vA-3to3A:
19.15
3r9vB-3to3A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unv ADMH

(Pantoea
agglomerans)
PF00221
(Lyase_aromatic)
4 LEU A 408
VAL A 246
LEU A 249
SER A 250
None
0.70A 3r9vA-3unvA:
1.4
3r9vB-3unvA:
2.0
3r9vA-3unvA:
21.78
3r9vB-3unvA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh3 C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER E


(Homo sapiens)
PF00059
(Lectin_C)
4 ILE A 204
ILE A 139
LEU A 127
SER A 128
None
0.68A 3r9vA-3wh3A:
undetectable
3r9vB-3wh3A:
undetectable
3r9vA-3wh3A:
19.00
3r9vB-3wh3A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zc4 SSO1398

(Sulfolobus
solfataricus)
no annotation 5 ILE A  19
ILE A  11
VAL A 153
LEU A 157
SER A 156
None
1.35A 3r9vA-3zc4A:
undetectable
3r9vB-3zc4A:
undetectable
3r9vA-3zc4A:
21.62
3r9vB-3zc4A:
21.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zqb PROTEIN PRGI, CELL
INVASION PROTEIN
SIPD


(Salmonella
enterica)
PF06511
(IpaD)
PF09392
(T3SS_needle_F)
4 ILE A 142
VAL A 323
LEU A 326
SER A 327
None
0.41A 3r9vA-3zqbA:
19.6
3r9vB-3zqbA:
15.6
3r9vA-3zqbA:
39.60
3r9vB-3zqbA:
39.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a8j ELONGATOR COMPLEX
PROTEIN 4


(Saccharomyces
cerevisiae)
PF05625
(PAXNEB)
4 ILE A 276
ILE A 272
VAL A 314
LEU A 317
None
0.68A 3r9vA-4a8jA:
undetectable
3r9vB-4a8jA:
undetectable
3r9vA-4a8jA:
22.86
3r9vB-4a8jA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4s BCL-2-LIKE PROTEIN
10


(Homo sapiens)
PF00452
(Bcl-2)
4 LEU A 146
VAL A 131
LEU A 134
SER A 135
None
0.53A 3r9vA-4b4sA:
undetectable
3r9vB-4b4sA:
undetectable
3r9vA-4b4sA:
21.43
3r9vB-4b4sA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL


(Homo sapiens)
PF07992
(Pyr_redox_2)
PF14721
(AIF_C)
4 ILE A 587
ILE A 591
VAL A 604
LEU A 607
None
0.66A 3r9vA-4bv6A:
undetectable
3r9vB-4bv6A:
undetectable
3r9vA-4bv6A:
19.88
3r9vB-4bv6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1


(Saccharomyces
cerevisiae)
PF09770
(PAT1)
4 ILE H 636
VAL H 596
LEU H 599
SER H 600
None
0.70A 3r9vA-4c8qH:
undetectable
3r9vB-4c8qH:
undetectable
3r9vA-4c8qH:
23.23
3r9vB-4c8qH:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2


(Neurospora
crassa)
PF00929
(RNase_T)
PF13423
(UCH_1)
4 LEU A1089
ILE A1052
LEU A1040
SER A1039
None
0.67A 3r9vA-4czwA:
undetectable
3r9vB-4czwA:
undetectable
3r9vA-4czwA:
19.50
3r9vB-4czwA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejr MAJOR CAPSID PROTEIN
VP60


(Rabbit
hemorrhagic
disease virus)
PF00915
(Calici_coat)
4 LEU A 173
ILE A 142
ILE A 144
VAL A 150
None
0.51A 3r9vA-4ejrA:
undetectable
3r9vB-4ejrA:
undetectable
3r9vA-4ejrA:
21.54
3r9vB-4ejrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es9 EPF

(Streptococcus
pyogenes)
no annotation 5 LEU A 145
ILE A 153
VAL A 226
LEU A 225
SER A 224
None
1.01A 3r9vA-4es9A:
undetectable
3r9vB-4es9A:
undetectable
3r9vA-4es9A:
23.01
3r9vB-4es9A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha6 PYRIDOXINE 4-OXIDASE

(Mesorhizobium
loti)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
4 ILE A  20
ILE A  22
LEU A  36
SER A  37
None
0.67A 3r9vA-4ha6A:
undetectable
3r9vB-4ha6A:
undetectable
3r9vA-4ha6A:
17.72
3r9vB-4ha6A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxt DE NOVO PROTEIN
OR329


(synthetic
construct)
PF00514
(Arm)
4 LEU A 220
ILE A 197
VAL A 172
LEU A 175
None
0.66A 3r9vA-4hxtA:
undetectable
3r9vB-4hxtA:
undetectable
3r9vA-4hxtA:
23.38
3r9vB-4hxtA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD


(Legionella
pneumophila)
no annotation 4 LEU A 139
ILE A 156
VAL A 128
LEU A 131
None
0.70A 3r9vA-4iikA:
undetectable
3r9vB-4iikA:
undetectable
3r9vA-4iikA:
20.82
3r9vB-4iikA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irf MALARIAL CLPB2
ATPASE/HSP101
PROTEIN


(Plasmodium
falciparum)
PF02861
(Clp_N)
4 ILE A  40
ILE A  19
VAL A 114
LEU A 117
None
0.65A 3r9vA-4irfA:
undetectable
3r9vB-4irfA:
undetectable
3r9vA-4irfA:
23.79
3r9vB-4irfA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE


(Paenibacillus
macerans)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
4 TRP A  54
ILE A  57
ILE A  61
LEU A  74
None
0.55A 3r9vA-4jclA:
undetectable
3r9vB-4jclA:
undetectable
3r9vA-4jclA:
18.56
3r9vB-4jclA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE


([Bacillus]
clarkii)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
4 TRP A  54
ILE A  57
ILE A  61
LEU A  74
None
0.53A 3r9vA-4jcmA:
undetectable
3r9vB-4jcmA:
undetectable
3r9vA-4jcmA:
17.69
3r9vB-4jcmA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jof GOLGI-ASSOCIATED PDZ
AND COILED-COIL
MOTIF-CONTAINING
PROTEIN


(Homo sapiens)
PF00595
(PDZ)
4 ILE A 303
VAL A 353
LEU A 356
SER A 357
None
0.56A 3r9vA-4jofA:
undetectable
3r9vB-4jofA:
undetectable
3r9vA-4jofA:
16.91
3r9vB-4jofA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdx GLUTATHIONE
S-TRANSFERASE DOMAIN


(Paraburkholderia
graminis)
PF00043
(GST_C)
PF13417
(GST_N_3)
4 LEU A 192
ILE A  97
LEU A 160
SER A 159
None
0.72A 3r9vA-4kdxA:
2.1
3r9vB-4kdxA:
undetectable
3r9vA-4kdxA:
22.22
3r9vB-4kdxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lik DNA PRIMASE SMALL
SUBUNIT


(Homo sapiens)
PF01896
(DNA_primase_S)
4 ILE A 142
VAL A 186
LEU A 189
SER A 190
None
0.40A 3r9vA-4likA:
undetectable
3r9vB-4likA:
undetectable
3r9vA-4likA:
22.58
3r9vB-4likA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5p NADPH DEHYDROGENASE

(Scheffersomyces
stipitis)
PF00724
(Oxidored_FMN)
4 ILE A 280
ILE A 283
VAL A 267
LEU A 270
None
0.68A 3r9vA-4m5pA:
undetectable
3r9vB-4m5pA:
undetectable
3r9vA-4m5pA:
22.75
3r9vB-4m5pA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv1 ENGINEERED PROTEIN
OR497


(synthetic
construct)
PF00514
(Arm)
4 LEU A 178
ILE A 155
VAL A 130
LEU A 133
None
0.67A 3r9vA-4rv1A:
undetectable
3r9vB-4rv1A:
undetectable
3r9vA-4rv1A:
23.15
3r9vB-4rv1A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv1 ENGINEERED PROTEIN
OR497


(synthetic
construct)
PF00514
(Arm)
4 LEU A 220
ILE A 197
VAL A 172
LEU A 175
None
0.69A 3r9vA-4rv1A:
undetectable
3r9vB-4rv1A:
undetectable
3r9vA-4rv1A:
23.15
3r9vB-4rv1A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv1 ENGINEERED PROTEIN
OR497


(synthetic
construct)
PF00514
(Arm)
4 LEU A 262
ILE A 239
VAL A 214
LEU A 217
None
0.65A 3r9vA-4rv1A:
undetectable
3r9vB-4rv1A:
undetectable
3r9vA-4rv1A:
23.15
3r9vB-4rv1A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38


(Homo sapiens)
no annotation 4 ILE A 103
ILE A 107
VAL A  85
LEU A  88
None
0.64A 3r9vA-4rxxA:
undetectable
3r9vB-4rxxA:
undetectable
3r9vA-4rxxA:
19.30
3r9vB-4rxxA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr1 GLUTAREDOXIN 3

(Alkaliphilus
oremlandii)
PF00462
(Glutaredoxin)
5 ILE A   4
ILE A   6
VAL A  19
LEU A  22
SER A  23
None
0.89A 3r9vA-4tr1A:
undetectable
3r9vB-4tr1A:
undetectable
3r9vA-4tr1A:
15.44
3r9vB-4tr1A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0t ADC-7 BETA-LACTAMASE

(Acinetobacter
baumannii)
PF00144
(Beta-lactamase)
5 LEU A 232
ILE A 331
ILE A 357
VAL A 353
LEU A 354
None
1.32A 3r9vA-4u0tA:
undetectable
3r9vB-4u0tA:
undetectable
3r9vA-4u0tA:
21.78
3r9vB-4u0tA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL


(Plasmodium
berghei)
no annotation 4 ILE A  79
VAL A  91
LEU A  94
SER A  95
None
0.53A 3r9vA-4u5aA:
undetectable
3r9vB-4u5aA:
3.2
3r9vA-4u5aA:
23.21
3r9vB-4u5aA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uu5 MAGUK P55 SUBFAMILY
MEMBER 5


(Homo sapiens)
PF00595
(PDZ)
4 ILE A 307
ILE A 309
VAL A 317
LEU A 320
None
0.62A 3r9vA-4uu5A:
undetectable
3r9vB-4uu5A:
undetectable
3r9vA-4uu5A:
13.84
3r9vB-4uu5A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybg PROTEIN MAELSTROM

(Drosophila
melanogaster)
PF13017
(Maelstrom)
4 ILE A 239
VAL A 194
LEU A 197
SER A 198
None
0.71A 3r9vA-4ybgA:
undetectable
3r9vB-4ybgA:
undetectable
3r9vA-4ybgA:
21.57
3r9vB-4ybgA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
4 ILE A 493
ILE A 495
VAL A 326
LEU A 329
None
0.69A 3r9vA-5agaA:
undetectable
3r9vB-5agaA:
undetectable
3r9vA-5agaA:
15.73
3r9vB-5agaA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis)
PF12897
(Aminotran_MocR)
4 ILE A 391
ILE A 393
VAL A 407
LEU A 410
None
0.70A 3r9vA-5c6uA:
undetectable
3r9vB-5c6uA:
undetectable
3r9vA-5c6uA:
22.27
3r9vB-5c6uA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
4 ILE A 233
VAL A 215
LEU A 218
SER A 219
None
0.55A 3r9vA-5dqfA:
undetectable
3r9vB-5dqfA:
undetectable
3r9vA-5dqfA:
18.73
3r9vB-5dqfA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron)
PF12771
(SusD-like_2)
4 ILE A 270
VAL A 255
LEU A 258
SER A 259
None
0.60A 3r9vA-5fq6A:
undetectable
3r9vB-5fq6A:
undetectable
3r9vA-5fq6A:
20.75
3r9vB-5fq6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkq PFVFT1

(Plasmodium
falciparum)
no annotation 4 ILE A 127
ILE A 128
VAL A  42
LEU A  45
None
0.70A 3r9vA-5jkqA:
undetectable
3r9vB-5jkqA:
undetectable
3r9vA-5jkqA:
23.35
3r9vB-5jkqA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liq NICKING ENDONUCLEASE
N.BSPD6I


(Bacillus sp.
(in: Bacteria))
PF09491
(RE_AlwI)
5 ILE A 268
ILE A 271
VAL A 139
LEU A 142
SER A 143
None
0.81A 3r9vA-5liqA:
undetectable
3r9vB-5liqA:
2.1
3r9vA-5liqA:
20.67
3r9vB-5liqA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc9 LAMININ SUBUNIT
ALPHA-1


(Mus musculus)
PF00054
(Laminin_G_1)
PF06009
(Laminin_II)
4 LEU A2292
ILE A2212
VAL A2177
LEU A2163
None
0.69A 3r9vA-5mc9A:
undetectable
3r9vB-5mc9A:
undetectable
3r9vA-5mc9A:
18.79
3r9vB-5mc9A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqj TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
no annotation 4 ILE W  98
ILE W  95
VAL W   9
LEU W  12
None
0.66A 3r9vA-5oqjW:
undetectable
3r9vB-5oqjW:
3.0
3r9vA-5oqjW:
undetectable
3r9vB-5oqjW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqm TRANSCRIPTION FACTOR
TFIIE SUBUNIT


(Saccharomyces
cerevisiae)
no annotation 4 ILE W  98
ILE W  95
VAL W   9
LEU W  12
None
0.69A 3r9vA-5oqmW:
undetectable
3r9vB-5oqmW:
2.3
3r9vA-5oqmW:
undetectable
3r9vB-5oqmW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ori ALBUMIN

(Capra hircus)
no annotation 4 ILE A 233
VAL A 215
LEU A 218
SER A 219
None
0.52A 3r9vA-5oriA:
undetectable
3r9vB-5oriA:
2.1
3r9vA-5oriA:
19.04
3r9vB-5oriA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL


(Aplysia
californica)
PF00520
(Ion_trans)
PF03493
(BK_channel_a)
4 LEU A 798
ILE A 754
VAL A 825
LEU A 745
None
0.70A 3r9vA-5tj6A:
3.4
3r9vB-5tj6A:
2.8
3r9vA-5tj6A:
14.73
3r9vB-5tj6A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE


(Homo sapiens;
Pyrococcus
abyssi)
PF00001
(7tm_1)
PF00534
(Glycos_transf_1)
4 ILE A1070
ILE A1072
VAL A1105
LEU A1108
None
0.69A 3r9vA-5u09A:
1.0
3r9vB-5u09A:
3.2
3r9vA-5u09A:
21.76
3r9vB-5u09A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2


(Arabidopsis
thaliana)
PF00201
(UDPGT)
4 ILE A 156
VAL A 141
LEU A 144
SER A 145
None
0.57A 3r9vA-5u6sA:
undetectable
3r9vB-5u6sA:
undetectable
3r9vA-5u6sA:
21.01
3r9vB-5u6sA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufl PROTEIN CIP2A

(Homo sapiens)
no annotation 5 ILE A 238
ILE A 241
VAL A 206
LEU A 209
SER A 210
None
1.09A 3r9vA-5uflA:
undetectable
3r9vB-5uflA:
undetectable
3r9vA-5uflA:
19.96
3r9vB-5uflA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium)
PF02310
(B12-binding)
4 LEU A 292
ILE A 358
ILE A 392
LEU A 342
None
0.64A 3r9vA-5ul4A:
2.8
3r9vB-5ul4A:
undetectable
3r9vA-5ul4A:
18.01
3r9vB-5ul4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjc PROTEIN MINI
SPINDLES


(Drosophila
melanogaster)
no annotation 4 ILE A1339
VAL A1377
LEU A1380
SER A1381
None
0.70A 3r9vA-5vjcA:
undetectable
3r9vB-5vjcA:
undetectable
3r9vA-5vjcA:
23.77
3r9vB-5vjcA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens)
no annotation 4 TRP A 452
ILE A 520
ILE A 522
VAL A 553
None
0.66A 3r9vA-5vm9A:
undetectable
3r9vB-5vm9A:
undetectable
3r9vA-5vm9A:
15.34
3r9vB-5vm9A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyl INNER TEGUMENT
PROTEIN


(Human
alphaherpesvirus
1)
PF03970
(Herpes_UL37_1)
4 ILE A 136
ILE A 140
VAL A 115
LEU A 118
None
0.71A 3r9vA-5vylA:
2.6
3r9vB-5vylA:
2.5
3r9vA-5vylA:
18.73
3r9vB-5vylA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wln TYPE II SECRETION
SYSTEM PROTEIN D


(Pseudomonas
aeruginosa)
no annotation 4 LEU G 252
ILE G 292
VAL G 310
LEU G 313
None
0.59A 3r9vA-5wlnG:
undetectable
3r9vB-5wlnG:
undetectable
3r9vA-5wlnG:
18.86
3r9vB-5wlnG:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x55 PROBABLE URACIL-DNA
GLYCOSYLASE


(Acanthamoeba
polyphaga
mimivirus)
PF03167
(UDG)
4 LEU A 279
ILE A 247
VAL A 177
LEU A 178
None
0.70A 3r9vA-5x55A:
undetectable
3r9vB-5x55A:
undetectable
3r9vA-5x55A:
22.19
3r9vB-5x55A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zgb PSAK

(Cyanidioschyzon
merolae)
no annotation 4 ILE K  12
VAL K  51
LEU K  54
SER K  55
None
0.67A 3r9vA-5zgbK:
undetectable
3r9vB-5zgbK:
undetectable
3r9vA-5zgbK:
undetectable
3r9vB-5zgbK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eux POLYMERASE BASIC
PROTEIN 2


(Influenza B
virus)
no annotation 4 ILE A 269
ILE A 273
LEU A 503
SER A 504
None
0.62A 3r9vA-6euxA:
undetectable
3r9vB-6euxA:
undetectable
3r9vA-6euxA:
undetectable
3r9vB-6euxA:
undetectable