SIMILAR PATTERNS OF AMINO ACIDS FOR 3R9V_B_DXCB1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 ILE A  61
LEU A  42
VAL A  50
SER A  54
 None
 1.00A 3r9vA-1aorA:
0.0
3r9vB-1aorA:
0.0		 3r9vA-1aorA:
18.81
3r9vB-1aorA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)

(Escherichia
coli) 		PF00490
(ALAD) 		4 LEU A  28
SER A 311
LEU A  33
VAL A  53
 None
 0.79A 3r9vA-1b4eA:
0.0
3r9vB-1b4eA:
0.0		 3r9vA-1b4eA:
23.39
3r9vB-1b4eA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbn PROTEIN
(LEUKOAGGLUTININ)

(Maackia
amurensis) 		PF00139
(Lectin_legB) 		4 ILE A  58
LEU A 203
LEU A 182
SER A  72
 None
 0.90A 3r9vA-1dbnA:
0.0
3r9vB-1dbnA:
0.0		 3r9vA-1dbnA:
22.85
3r9vB-1dbnA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 ILE A 123
LEU A 340
LEU A 390
VAL A 406
 None
 0.99A 3r9vA-1dq3A:
1.2
3r9vB-1dq3A:
1.3		 3r9vA-1dq3A:
21.64
3r9vB-1dq3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 ILE A 241
LEU A 351
VAL A 330
SER A 338
 None
 0.89A 3r9vA-1f82A:
0.0
3r9vB-1f82A:
0.0		 3r9vA-1f82A:
20.79
3r9vB-1f82A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5c BETA-CARBONIC
ANHYDRASE

(Methanothermobacter
thermautotrophicus) 		PF00484
(Pro_CA) 		4 ILE A  47
LEU A  45
VAL A  66
SER A  69
 None
 0.99A 3r9vA-1g5cA:
0.0
3r9vB-1g5cA:
0.0		 3r9vA-1g5cA:
17.77
3r9vB-1g5cA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Escherichia
coli) 		PF02668
(TauD) 		4 ILE A  18
LEU A  35
VAL A 252
SER A 130
 None
 0.93A 3r9vA-1gy9A:
0.0
3r9vB-1gy9A:
0.0		 3r9vA-1gy9A:
20.20
3r9vB-1gy9A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwn EBULIN

(Sambucus ebulus) 		PF00161
(RIP) 		4 LEU A 178
LEU A  10
VAL A  67
SER A  69
 None
 0.99A 3r9vA-1hwnA:
0.0
3r9vB-1hwnA:
0.0		 3r9vA-1hwnA:
21.23
3r9vB-1hwnA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ILE A 159
LEU A 211
LEU A 192
SER A 395
 None
 0.96A 3r9vA-1iyxA:
0.0
3r9vB-1iyxA:
0.0		 3r9vA-1iyxA:
20.27
3r9vB-1iyxA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI

(Pantoea
stewartii) 		PF00765
(Autoind_synth) 		4 ILE A 118
LEU A 112
VAL A  36
SER A  39
 None
 0.99A 3r9vA-1k4jA:
2.2
3r9vB-1k4jA:
undetectable		 3r9vA-1k4jA:
22.22
3r9vB-1k4jA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		4 ILE A  37
LEU A  32
LEU A  25
VAL A  45
 None
 1.00A 3r9vA-1lwhA:
undetectable
3r9vB-1lwhA:
undetectable		 3r9vA-1lwhA:
21.65
3r9vB-1lwhA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ILE A 149
LEU A  21
VAL A  27
SER A  31
 None
 1.00A 3r9vA-1lxtA:
undetectable
3r9vB-1lxtA:
undetectable		 3r9vA-1lxtA:
20.04
3r9vB-1lxtA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6j TRIOSEPHOSPHATE
ISOMERASE

(Entamoeba
histolytica) 		PF00121
(TIM) 		4 ILE A 235
LEU A 229
HIS A 194
SER A 103
 None
 0.82A 3r9vA-1m6jA:
undetectable
3r9vB-1m6jA:
undetectable		 3r9vA-1m6jA:
21.64
3r9vB-1m6jA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF01380
(SIS) 		4 ILE A 344
LEU A 371
LEU A 278
VAL A 434
 None
 0.96A 3r9vA-1morA:
1.3
3r9vB-1morA:
2.5		 3r9vA-1morA:
23.88
3r9vB-1morA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n31 L-CYSTEINE/CYSTINE
LYASE C-DES

(Synechocystis
sp. PCC 6714) 		PF00266
(Aminotran_5) 		4 ILE A 179
LEU A 174
SER A 201
VAL A  88
 None
None
None
PLP  A2001 (-4.1A)
 0.96A 3r9vA-1n31A:
undetectable
3r9vB-1n31A:
undetectable		 3r9vA-1n31A:
18.09
3r9vB-1n31A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		5 ILE A  57
LEU A   4
LEU A 200
VAL A 156
SER A 132
 None
 1.35A 3r9vA-1ocmA:
undetectable
3r9vB-1ocmA:
undetectable		 3r9vA-1ocmA:
19.81
3r9vB-1ocmA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ow1 SMART/HDAC1
ASSOCIATED REPRESSOR
PROTEIN

(Homo sapiens) 		PF07744
(SPOC) 		5 ILE A3650
LEU A3646
LEU A3575
HIS A3656
VAL A3563
 None
 1.44A 3r9vA-1ow1A:
undetectable
3r9vB-1ow1A:
undetectable		 3r9vA-1ow1A:
21.59
3r9vB-1ow1A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psw ADP-HEPTOSE LPS
HEPTOSYLTRANSFERASE
II

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		4 ILE A  33
LEU A  24
LEU A 138
SER A  93
 None
 0.95A 3r9vA-1pswA:
undetectable
3r9vB-1pswA:
undetectable		 3r9vA-1pswA:
23.01
3r9vB-1pswA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		4 ILE A 179
LEU A 183
SER A 140
VAL A 103
 VIV  A 301 ( 4.0A)
None
VIV  A 301 (-3.1A)
None
 0.98A 3r9vA-1r5lA:
undetectable
3r9vB-1r5lA:
undetectable		 3r9vA-1r5lA:
21.78
3r9vB-1r5lA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ILE A  20
LEU A  21
SER A 770
VAL A 761
 None
 0.98A 3r9vA-1r8wA:
undetectable
3r9vB-1r8wA:
undetectable		 3r9vA-1r8wA:
17.99
3r9vB-1r8wA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 LEU A 159
HIS A 242
VAL A 233
SER A 236
 None
 0.94A 3r9vA-1rzvA:
undetectable
3r9vB-1rzvA:
undetectable		 3r9vA-1rzvA:
22.31
3r9vB-1rzvA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcd TRIOSEPHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00121
(TIM) 		4 ILE A 229
LEU A 223
HIS A 188
SER A  97
 None
 0.82A 3r9vA-1tcdA:
undetectable
3r9vB-1tcdA:
undetectable		 3r9vA-1tcdA:
22.86
3r9vB-1tcdA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A

(Staphylococcus
aureus) 		PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14) 		4 ILE A  87
LEU A 115
LEU A 108
VAL A 164
 None
 0.98A 3r9vA-1tv8A:
undetectable
3r9vB-1tv8A:
undetectable		 3r9vA-1tv8A:
20.40
3r9vB-1tv8A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF13476
(AAA_23)
no annotation 		4 ILE A 146
LEU A 147
LEU B 792
SER B 765
 None
 0.95A 3r9vA-1us8A:
undetectable
3r9vB-1us8A:
undetectable		 3r9vA-1us8A:
22.27
3r9vB-1us8A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A

(Homo sapiens) 		PF03770
(IPK) 		4 ILE A 415
LEU A 401
LEU A 261
SER A 324
 ADP  A1462 ( 4.2A)
ADP  A1462 ( 4.6A)
None
None
 0.93A 3r9vA-1w2dA:
undetectable
3r9vB-1w2dA:
undetectable		 3r9vA-1w2dA:
18.49
3r9vB-1w2dA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5t ORC2

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 LEU A 306
SER A 364
VAL A 189
SER A 193
 None
 1.00A 3r9vA-1w5tA:
undetectable
3r9vB-1w5tA:
undetectable		 3r9vA-1w5tA:
21.60
3r9vB-1w5tA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9z VP9

(Banna virus) 		PF08978
(Reoviridae_Vp9) 		4 ILE A 273
LEU A 144
LEU A 165
SER A 244
 None
 1.00A 3r9vA-1w9zA:
undetectable
3r9vB-1w9zA:
undetectable		 3r9vA-1w9zA:
24.22
3r9vB-1w9zA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x40 ARAP2

(Homo sapiens) 		PF00536
(SAM_1) 		4 ILE A  56
LEU A  53
LEU A  71
VAL A  16
 None
 0.80A 3r9vA-1x40A:
undetectable
3r9vB-1x40A:
undetectable		 3r9vA-1x40A:
14.69
3r9vB-1x40A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N) 		4 ILE A  93
LEU A  68
LEU A 327
VAL A  20
 None
 0.93A 3r9vA-1xa0A:
undetectable
3r9vB-1xa0A:
undetectable		 3r9vA-1xa0A:
21.49
3r9vB-1xa0A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytu HYPOTHETICAL PROTEIN
AF1318

(Archaeoglobus
fulgidus) 		PF02171
(Piwi) 		4 ILE A 289
LEU A 268
LEU A 223
HIS A 291
 None
 0.91A 3r9vA-1ytuA:
undetectable
3r9vB-1ytuA:
undetectable		 3r9vA-1ytuA:
20.65
3r9vB-1ytuA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE

(Homo sapiens) 		PF00103
(Hormone_1) 		4 LEU A 117
LEU A 124
VAL A 185
SER A 188
 None
 0.95A 3r9vA-1z7cA:
4.1
3r9vB-1z7cA:
4.2		 3r9vA-1z7cA:
21.50
3r9vB-1z7cA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb7 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 ILE A 242
LEU A 351
VAL A 330
SER A 338
 None
 0.96A 3r9vA-1zb7A:
undetectable
3r9vB-1zb7A:
undetectable		 3r9vA-1zb7A:
21.57
3r9vB-1zb7A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aoq DNA MISMATCH REPAIR
PROTEIN MUTH

(Haemophilus
influenzae) 		PF02976
(MutH) 		5 ILE A 197
LEU A 170
LEU A 183
VAL A 113
SER A 111
 None
 1.17A 3r9vA-2aoqA:
undetectable
3r9vB-2aoqA:
undetectable		 3r9vA-2aoqA:
23.40
3r9vB-2aoqA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 ILE A 359
LEU A 356
LEU A 710
VAL A1013
 None
 0.81A 3r9vA-2b5mA:
undetectable
3r9vB-2b5mA:
undetectable		 3r9vA-2b5mA:
15.08
3r9vB-2b5mA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon) 		PF07859
(Abhydrolase_3) 		4 ILE A 304
SER A 164
LEU A 180
SER A 269
 None
 0.94A 3r9vA-2c7bA:
undetectable
3r9vB-2c7bA:
undetectable		 3r9vA-2c7bA:
22.56
3r9vB-2c7bA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN

(Pyrococcus
horikoshii) 		PF00574
(CLP_protease) 		5 ILE A 189
LEU A 193
LEU A 212
VAL A 205
SER A  80
 None
 1.48A 3r9vA-2deoA:
undetectable
3r9vB-2deoA:
undetectable		 3r9vA-2deoA:
22.15
3r9vB-2deoA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2l PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-LC
ISOFORM LCA
PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX

(Drosophila
melanogaster;
Drosophila
melanogaster) 		PF01510
(Amidase_2)
PF01510
(Amidase_2) 		4 ILE A 456
LEU A 421
VAL X 383
SER X 386
 None
 1.00A 3r9vA-2f2lA:
undetectable
3r9vB-2f2lA:
undetectable		 3r9vA-2f2lA:
20.21
3r9vB-2f2lA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzf GLUTAREDOXIN-1

(Ectromelia
virus) 		PF00462
(Glutaredoxin) 		4 ILE A 102
LEU A  99
LEU A  33
VAL A  19
 None
 1.01A 3r9vA-2hzfA:
undetectable
3r9vB-2hzfA:
undetectable		 3r9vA-2hzfA:
18.02
3r9vB-2hzfA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9e TRIOSEPHOSPHATE
ISOMERASE

(Tenebrio
molitor) 		PF00121
(TIM) 		4 ILE A 225
LEU A 219
HIS A 184
SER A  95
 None
 0.88A 3r9vA-2i9eA:
undetectable
3r9vB-2i9eA:
undetectable		 3r9vA-2i9eA:
21.68
3r9vB-2i9eA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2
G2/MITOTIC-SPECIFIC
CYCLIN-B1

(Homo sapiens;
Homo sapiens) 		PF00069
(Pkinase)
PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		4 ILE A  35
LEU A  76
LEU B 290
SER B 256
 None
 0.79A 3r9vA-2jgzA:
1.6
3r9vB-2jgzA:
undetectable		 3r9vA-2jgzA:
21.45
3r9vB-2jgzA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3n TUSP1

(Nephila
antipodiana) 		PF12042
(RP1-2) 		4 ILE A  66
LEU A  64
LEU A 126
VAL A  80
 None
 1.00A 3r9vA-2k3nA:
undetectable
3r9vB-2k3nA:
undetectable		 3r9vA-2k3nA:
19.93
3r9vB-2k3nA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lem APOLIPOPROTEIN A-I

(Mus musculus) 		PF01442
(Apolipoprotein) 		4 SER A 172
LEU A 208
HIS A 196
SER A  24
 None
 0.93A 3r9vA-2lemA:
4.6
3r9vB-2lemA:
3.8		 3r9vA-2lemA:
21.93
3r9vB-2lemA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lnl C-X-C CHEMOKINE
RECEPTOR TYPE 1

(Homo sapiens) 		PF00001
(7tm_1) 		4 LEU A  65
SER A 298
LEU A  81
SER A  53
 None
 0.96A 3r9vA-2lnlA:
2.1
3r9vB-2lnlA:
1.7		 3r9vA-2lnlA:
23.10
3r9vB-2lnlA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2luw METALLOPROTEASE

(Vibrio
vulnificus) 		PF04151
(PPC) 		4 ILE A  86
LEU A  13
VAL A  34
SER A  73
 None
 1.00A 3r9vA-2luwA:
undetectable
3r9vB-2luwA:
undetectable		 3r9vA-2luwA:
17.78
3r9vB-2luwA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbg RALA-BINDING PROTEIN
1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 ILE A 342
LEU A 346
LEU A 271
VAL A 212
 None
 0.91A 3r9vA-2mbgA:
2.1
3r9vB-2mbgA:
2.9		 3r9vA-2mbgA:
22.54
3r9vB-2mbgA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2msv MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		no annotation 4 ILE A   7
LEU A   4
LEU A  45
SER A 125
 None
 0.96A 3r9vA-2msvA:
undetectable
3r9vB-2msvA:
undetectable		 3r9vA-2msvA:
19.86
3r9vB-2msvA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2

(Homo sapiens) 		PF01728
(FtsJ) 		4 ILE A 168
LEU A 102
HIS A  17
VAL A  44
 None
 0.97A 3r9vA-2nyuA:
undetectable
3r9vB-2nyuA:
undetectable		 3r9vA-2nyuA:
21.83
3r9vB-2nyuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2onk MOLYBDATE/TUNGSTATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Archaeoglobus
fulgidus) 		PF00005
(ABC_tran) 		4 ILE A  44
LEU A  41
LEU A 150
VAL A 172
 None
 0.97A 3r9vA-2onkA:
undetectable
3r9vB-2onkA:
undetectable		 3r9vA-2onkA:
22.40
3r9vB-2onkA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bacillus cereus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  85
LEU A  74
LEU A  66
HIS A  86
 None
 0.92A 3r9vA-2p88A:
undetectable
3r9vB-2p88A:
undetectable		 3r9vA-2p88A:
21.21
3r9vB-2p88A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC

(Mus musculus) 		PF00162
(PGK) 		4 ILE A 302
LEU A 244
SER A 255
VAL A 341
 None
None
None
ATP  A 500 (-3.9A)
 1.00A 3r9vA-2paaA:
undetectable
3r9vB-2paaA:
undetectable		 3r9vA-2paaA:
22.75
3r9vB-2paaA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbz HYPOTHETICAL PROTEIN

(Thermococcus
kodakarensis) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		4 SER A  56
LEU A  74
VAL A  64
SER A   6
 None
 1.00A 3r9vA-2pbzA:
undetectable
3r9vB-2pbzA:
undetectable		 3r9vA-2pbzA:
21.47
3r9vB-2pbzA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcu CARBOXYPEPTIDASE A4

(Homo sapiens) 		PF00246
(Peptidase_M14) 		4 LEU A 195
LEU A 107
VAL A  87
SER A  88
 None
 0.94A 3r9vA-2pcuA:
undetectable
3r9vB-2pcuA:
undetectable		 3r9vA-2pcuA:
19.69
3r9vB-2pcuA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Helicobacter
pylori) 		PF13561
(adh_short_C2) 		4 LEU A 232
LEU A 186
VAL A 219
SER A 220
 None
 1.01A 3r9vA-2pd3A:
undetectable
3r9vB-2pd3A:
undetectable		 3r9vA-2pd3A:
25.16
3r9vB-2pd3A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		4 ILE A  86
SER A 171
VAL A 210
SER A 214
 None
 0.93A 3r9vA-2phkA:
2.6
3r9vB-2phkA:
undetectable		 3r9vA-2phkA:
20.00
3r9vB-2phkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 ILE A  32
LEU A  69
SER A 111
LEU A  93
VAL A  86
 None
 1.33A 3r9vA-2pkgA:
undetectable
3r9vB-2pkgA:
undetectable		 3r9vA-2pkgA:
17.92
3r9vB-2pkgA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3o 12-OXOPHYTODIENOATE
REDUCTASE 3

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		4 ILE A 133
LEU A 246
VAL A  67
SER A  68
 None
 0.94A 3r9vA-2q3oA:
undetectable
3r9vB-2q3oA:
undetectable		 3r9vA-2q3oA:
20.70
3r9vB-2q3oA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdx FERREDOXIN REDUCTASE

(Pseudomonas
aeruginosa) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 110
LEU A 113
VAL A 231
SER A 234
 None
 0.89A 3r9vA-2qdxA:
undetectable
3r9vB-2qdxA:
undetectable		 3r9vA-2qdxA:
21.43
3r9vB-2qdxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ILE A 519
LEU A 522
LEU A 393
VAL A 504
 None
 0.88A 3r9vA-2qykA:
undetectable
3r9vB-2qykA:
undetectable		 3r9vA-2qykA:
21.02
3r9vB-2qykA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9y ALPHA-2-ANTIPLASMIN

(Mus musculus) 		PF00079
(Serpin) 		5 ILE A 139
LEU A 202
LEU A 332
HIS A  92
VAL A 108
 None
 1.28A 3r9vA-2r9yA:
undetectable
3r9vB-2r9yA:
undetectable		 3r9vA-2r9yA:
21.51
3r9vB-2r9yA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfb CYTOCHROME P450

(Picrophilus
torridus) 		PF00067
(p450) 		4 ILE A 116
LEU A 120
SER A  71
LEU A 172
 None
 0.86A 3r9vA-2rfbA:
1.7
3r9vB-2rfbA:
1.4		 3r9vA-2rfbA:
20.77
3r9vB-2rfbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 ILE G 244
LEU G 173
HIS G 248
VAL G 117
 None
 0.96A 3r9vA-2uv8G:
undetectable
3r9vB-2uv8G:
undetectable		 3r9vA-2uv8G:
9.22
3r9vB-2uv8G:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 ILE A 216
LEU A 211
LEU A 202
VAL A 224
 None
 0.88A 3r9vA-2vr5A:
undetectable
3r9vB-2vr5A:
undetectable		 3r9vA-2vr5A:
18.75
3r9vB-2vr5A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 ILE A 103
LEU A 101
SER A  52
LEU A 207
 None
 0.98A 3r9vA-2vxoA:
undetectable
3r9vB-2vxoA:
undetectable		 3r9vA-2vxoA:
17.80
3r9vB-2vxoA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		4 ILE A 260
SER A 296
LEU A 219
VAL A 226
 None
 0.97A 3r9vA-2wedA:
undetectable
3r9vB-2wedA:
undetectable		 3r9vA-2wedA:
23.99
3r9vB-2wedA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 ILE A 193
LEU A 188
LEU A 179
VAL A 201
 None
 0.86A 3r9vA-2wskA:
undetectable
3r9vB-2wskA:
undetectable		 3r9vA-2wskA:
17.55
3r9vB-2wskA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 ILE A 496
LEU A 447
LEU A 512
HIS A 497
 None
 1.01A 3r9vA-2wskA:
undetectable
3r9vB-2wskA:
undetectable		 3r9vA-2wskA:
17.55
3r9vB-2wskA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 ILE A 299
LEU A 386
LEU A 173
VAL A  54
 None
 1.00A 3r9vA-2wyaA:
undetectable
3r9vB-2wyaA:
undetectable		 3r9vA-2wyaA:
21.72
3r9vB-2wyaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ILE A 480
LEU A 483
LEU A 189
VAL A 157
 None
 0.91A 3r9vA-2xf2A:
undetectable
3r9vB-2xf2A:
undetectable		 3r9vA-2xf2A:
17.74
3r9vB-2xf2A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 LEU A 485
LEU A 471
HIS A 438
VAL A 411
 None
 0.78A 3r9vA-2xpzA:
undetectable
3r9vB-2xpzA:
undetectable		 3r9vA-2xpzA:
18.44
3r9vB-2xpzA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		5 ILE A 248
LEU A 253
LEU A 430
HIS A 226
VAL A 577
 None
 1.26A 3r9vA-2xydA:
undetectable
3r9vB-2xydA:
undetectable		 3r9vA-2xydA:
19.21
3r9vB-2xydA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN
GENE 0.3 PROTEIN

(Escherichia
coli;
Escherichia
virus T7) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N)
PF08684
(ocr) 		4 ILE D  23
LEU D  29
LEU D  89
SER B 286
 None
 0.91A 3r9vA-2y7cD:
undetectable
3r9vB-2y7cD:
undetectable		 3r9vA-2y7cD:
19.22
3r9vB-2y7cD:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfu CEREBRAL PROTEIN 1

(Homo sapiens) 		PF05148
(Methyltransf_8) 		4 ILE A 326
LEU A 322
VAL A 381
SER A 356
 None
 0.97A 3r9vA-2zfuA:
undetectable
3r9vB-2zfuA:
undetectable		 3r9vA-2zfuA:
22.66
3r9vB-2zfuA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a05 TRYPTOPHANYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		5 LEU A 268
LEU A 345
HIS A  84
VAL A 305
SER A 304
 None
None
None
SF4  A 373 ( 4.3A)
None
 1.50A 3r9vA-3a05A:
undetectable
3r9vB-3a05A:
undetectable		 3r9vA-3a05A:
21.67
3r9vB-3a05A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9v 4-COUMARATE--COA
LIGASE

(Populus
tomentosa) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 227
HIS A 294
VAL A 281
SER A 284
 None
 0.85A 3r9vA-3a9vA:
undetectable
3r9vB-3a9vA:
undetectable		 3r9vA-3a9vA:
18.68
3r9vB-3a9vA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgf F26G19 FAB
F26G19 FAB

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 ILE H  37
LEU H  45
SER L  34
VAL L  58
 None
 0.99A 3r9vA-3bgfH:
undetectable
3r9vB-3bgfH:
undetectable		 3r9vA-3bgfH:
22.90
3r9vB-3bgfH:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq9 PREDICTED ROSSMANN
FOLD
NUCLEOTIDE-BINDING
DOMAIN-CONTAINING
PROTEIN

(Idiomarina
baltica) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		4 ILE A 351
LEU A 349
LEU A 278
VAL A 249
 None
 0.95A 3r9vA-3bq9A:
undetectable
3r9vB-3bq9A:
undetectable		 3r9vA-3bq9A:
21.52
3r9vB-3bq9A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c30 AUTOINDUCER 2 SENSOR
KINASE/PHOSPHATASE
LUXQ

(Vibrio cholerae) 		PF09308
(LuxQ-periplasm) 		4 ILE A 190
LEU A 168
LEU A 254
SER A 206
 None
 0.88A 3r9vA-3c30A:
undetectable
3r9vB-3c30A:
undetectable		 3r9vA-3c30A:
26.28
3r9vB-3c30A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfx UPF0100 PROTEIN
MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		4 ILE A 239
LEU A 230
SER A 167
VAL A 208
 None
 0.97A 3r9vA-3cfxA:
undetectable
3r9vB-3cfxA:
undetectable		 3r9vA-3cfxA:
21.78
3r9vB-3cfxA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwx PROTEIN CAGD

(Helicobacter
pylori) 		PF16567
(CagD) 		4 ILE A  99
LEU A 163
LEU A 137
SER A 113
 None
 0.93A 3r9vA-3cwxA:
undetectable
3r9vB-3cwxA:
undetectable		 3r9vA-3cwxA:
22.97
3r9vB-3cwxA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8h GLYCOLYTIC
PHOSPHOGLYCERATE
MUTASE

(Cryptosporidium
parvum) 		PF00300
(His_Phos_1) 		4 ILE A  26
LEU A 104
VAL A 185
SER A 189
 None
 0.97A 3r9vA-3d8hA:
undetectable
3r9vB-3d8hA:
undetectable		 3r9vA-3d8hA:
23.79
3r9vB-3d8hA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1

(Cavia porcellus) 		PF00106
(adh_short) 		4 LEU A 190
LEU A 118
HIS A 145
VAL A 103
 None
 0.96A 3r9vA-3dwfA:
undetectable
3r9vB-3dwfA:
undetectable		 3r9vA-3dwfA:
23.78
3r9vB-3dwfA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF13377
(Peripla_BP_3) 		4 ILE A 188
LEU A 180
LEU A 337
SER A 168
 None
 0.97A 3r9vA-3e3mA:
undetectable
3r9vB-3e3mA:
undetectable		 3r9vA-3e3mA:
22.06
3r9vB-3e3mA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		4 ILE A  55
LEU A 104
SER A 107
VAL A  31
 None
None
MLY  A 314 ( 4.8A)
None
 0.90A 3r9vA-3e3xA:
undetectable
3r9vB-3e3xA:
undetectable		 3r9vA-3e3xA:
25.14
3r9vB-3e3xA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e98 GAF DOMAIN OF
UNKNOWN FUNCTION

(Pseudomonas
aeruginosa) 		PF04340
(DUF484) 		4 ILE A 144
LEU A 148
LEU A 183
VAL A 106
 None
 0.91A 3r9vA-3e98A:
2.6
3r9vB-3e98A:
2.4		 3r9vA-3e98A:
23.40
3r9vB-3e98A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epj TRNA
ISOPENTENYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01715
(IPPT) 		4 ILE A 300
LEU A 304
SER A  45
SER A  31
 None
 1.00A 3r9vA-3epjA:
undetectable
3r9vB-3epjA:
undetectable		 3r9vA-3epjA:
21.84
3r9vB-3epjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etv PROTEIN TRANSPORT
PROTEIN TIP20,
PROTEIN TRANSPORT
PROTEIN DSL1 CHIMERA

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		4 ILE A  10
LEU A  96
VAL A 132
SER A 133
 None
 0.91A 3r9vA-3etvA:
undetectable
3r9vB-3etvA:
3.1		 3r9vA-3etvA:
25.48
3r9vB-3etvA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzq PUTATIVE HYDROLASE

(Clostridioides
difficile) 		PF08282
(Hydrolase_3) 		4 ILE A 273
LEU A 267
LEU A   9
VAL A  55
 None
 1.00A 3r9vA-3fzqA:
undetectable
3r9vB-3fzqA:
undetectable		 3r9vA-3fzqA:
23.05
3r9vB-3fzqA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqs ADENYLATE
CYCLASE-LIKE PROTEIN

(Chlamydia
trachomatis) 		PF16697
(Yop-YscD_cpl) 		5 ILE A  45
LEU A  40
LEU A   7
HIS A  49
VAL A  60
 None
 1.41A 3r9vA-3gqsA:
undetectable
3r9vB-3gqsA:
undetectable		 3r9vA-3gqsA:
18.47
3r9vB-3gqsA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Yersinia pestis) 		PF00425
(Chorismate_bind) 		4 LEU A  41
SER A 255
LEU A 253
SER A 444
 None
 0.92A 3r9vA-3gseA:
undetectable
3r9vB-3gseA:
undetectable		 3r9vA-3gseA:
20.17
3r9vB-3gseA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 LEU C 152
HIS C 137
VAL C 250
SER C 210
 None
 1.00A 3r9vA-3gzdC:
undetectable
3r9vB-3gzdC:
undetectable		 3r9vA-3gzdC:
21.22
3r9vB-3gzdC:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhr HUMAN GROWTH HORMONE

(Homo sapiens) 		PF00103
(Hormone_1) 		4 LEU A 117
LEU A 124
VAL A 185
SER A 188
 None
 1.00A 3r9vA-3hhrA:
undetectable
3r9vB-3hhrA:
3.5		 3r9vA-3hhrA:
20.48
3r9vB-3hhrA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 ILE A 263
LEU A 234
VAL A 341
SER A 253
 None
 1.01A 3r9vA-3hjeA:
undetectable
3r9vB-3hjeA:
1.5		 3r9vA-3hjeA:
17.85
3r9vB-3hjeA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl0 MALEYLACETATE
REDUCTASE

(Agrobacterium
fabrum) 		PF00465
(Fe-ADH) 		4 ILE A 332
LEU A 237
LEU A 260
VAL A 309
 None
 0.84A 3r9vA-3hl0A:
undetectable
3r9vB-3hl0A:
undetectable		 3r9vA-3hl0A:
21.87
3r9vB-3hl0A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		4 ILE A 287
LEU A 309
VAL A  29
SER A  27
 None
 0.93A 3r9vA-3hxwA:
undetectable
3r9vB-3hxwA:
undetectable		 3r9vA-3hxwA:
22.69
3r9vB-3hxwA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		4 LEU A 359
LEU A 309
VAL A  29
SER A  27
 None
 0.82A 3r9vA-3hxwA:
undetectable
3r9vB-3hxwA:
undetectable		 3r9vA-3hxwA:
22.69
3r9vB-3hxwA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ia7 CALG4

(Micromonospora
echinospora) 		PF00201
(UDPGT) 		4 SER A 354
LEU A 350
VAL A 320
SER A 343
 None
 0.90A 3r9vA-3ia7A:
undetectable
3r9vB-3ia7A:
undetectable		 3r9vA-3ia7A:
20.83
3r9vB-3ia7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6x SOLUTE-BINDING
PROTEIN MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		4 ILE A 239
LEU A 230
SER A 167
VAL A 208
 None
 1.00A 3r9vA-3k6xA:
undetectable
3r9vB-3k6xA:
undetectable		 3r9vA-3k6xA:
22.03
3r9vB-3k6xA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krs TRIOSEPHOSPHATE
ISOMERASE

(Cryptosporidium
parvum) 		PF00121
(TIM) 		4 ILE A 228
LEU A 222
HIS A 187
SER A  98
 None
 0.83A 3r9vA-3krsA:
undetectable
3r9vB-3krsA:
undetectable		 3r9vA-3krsA:
24.37
3r9vB-3krsA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Jannaschia sp.
CCS1) 		PF07848
(PaaX) 		4 LEU A  23
LEU A  47
HIS A 211
SER A  35
 None
None
SO4  A 266 (-3.5A)
None
 0.94A 3r9vA-3l09A:
undetectable
3r9vB-3l09A:
undetectable		 3r9vA-3l09A:
21.90
3r9vB-3l09A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l10 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ILE A  99
LEU A 116
LEU A  72
VAL A  48
 None
 0.89A 3r9vA-3l10A:
undetectable
3r9vB-3l10A:
undetectable		 3r9vA-3l10A:
22.64
3r9vB-3l10A:
22.64