SIMILAR PATTERNS OF AMINO ACIDS FOR 3R9T_C_BEZC264_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoc COAGULOGEN

(Tachypleus
tridentatus)
PF02035
(Coagulin)
4 ALA A  33
GLU A  31
GLU A  35
ALA A 113
None
1.05A 3r9tC-1aocA:
undetectable
3r9tC-1aocA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dub 2-ENOYL-COA
HYDRATASE


(Rattus
norvegicus)
PF00378
(ECH_1)
4 ALA A  98
GLU A 144
GLU A 164
ALA A 173
CAA  A 300 (-3.6A)
CAA  A 300 ( 3.0A)
CAA  A 300 ( 3.5A)
CAA  A 300 ( 4.7A)
0.38A 3r9tC-1dubA:
26.6
3r9tC-1dubA:
36.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)


(Paracoccus
denitrificans)
PF00766
(ETF_alpha)
PF01012
(ETF)
4 ALA A  22
GLU A   8
ALA A  91
MET A  99
None
1.43A 3r9tC-1efpA:
undetectable
3r9tC-1efpA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgc BACTERIOFERRITIN

(Rhodobacter
capsulatus)
PF00210
(Ferritin)
4 ALA A  21
GLU A 127
GLU A  94
ALA A  97
None
1.49A 3r9tC-1jgcA:
undetectable
3r9tC-1jgcA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgc BACTERIOFERRITIN

(Rhodobacter
capsulatus)
PF00210
(Ferritin)
4 ALA A  97
GLU A  51
GLU A  18
ALA A  21
None
1.42A 3r9tC-1jgcA:
undetectable
3r9tC-1jgcA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE


(Brevundimonas
diminuta)
PF01804
(Penicil_amidase)
4 ALA A 665
GLU A 624
ALA A 596
MET A 585
None
1.45A 3r9tC-1kehA:
undetectable
3r9tC-1kehA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE


(Methanothermobacter
marburgensis)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
4 ALA A 114
GLU A 259
ALA A 254
MET A 235
None
1.18A 3r9tC-1mroA:
undetectable
3r9tC-1mroA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
4 ALA A 187
GLU A 217
ALA A 218
MET A 158
None
1.43A 3r9tC-1nfgA:
undetectable
3r9tC-1nfgA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sef CONSERVED
HYPOTHETICAL PROTEIN


(Enterococcus
faecalis)
PF05899
(Cupin_3)
PF07883
(Cupin_2)
4 ALA A 240
GLU A 163
GLU A 199
ALA A 196
None
1.08A 3r9tC-1sefA:
undetectable
3r9tC-1sefA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuu ACETATE KINASE

(Methanosarcina
thermophila)
PF00871
(Acetate_kinase)
4 ALA A 301
GLU A 299
GLU A 303
ALA A 291
None
1.32A 3r9tC-1tuuA:
undetectable
3r9tC-1tuuA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuf HYPOTHETICAL PROTEIN
LIN2664


(Listeria
innocua)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ALA A1265
GLU A1059
GLU A1098
ALA A1100
None
1.44A 3r9tC-1wufA:
undetectable
3r9tC-1wufA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yuz NIGERYTHRIN

(Desulfovibrio
vulgaris)
PF02915
(Rubrerythrin)
4 ALA A 148
GLU A  73
GLU A 115
ALA A  72
None
FE2  A 302 ( 2.4A)
FE2  A 302 (-1.9A)
None
1.28A 3r9tC-1yuzA:
undetectable
3r9tC-1yuzA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN


(Bacillus cereus)
PF00903
(Glyoxalase)
4 ALA A 309
GLU A  64
ALA A  17
MET A  35
None
1.39A 3r9tC-1zswA:
undetectable
3r9tC-1zswA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE


(Thermus
thermophilus)
PF01063
(Aminotran_4)
4 ALA A 139
GLU A 197
GLU A 181
ALA A 258
None
1.33A 3r9tC-2ej0A:
undetectable
3r9tC-2ej0A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9y ACETYL-COA
CARBOXYLASE,
CARBOXYLTRANSFERASE
ALPHA CHAIN


(Escherichia
coli)
PF03255
(ACCA)
4 ALA A  64
GLU A 231
ALA A 244
MET A 251
None
1.45A 3r9tC-2f9yA:
10.8
3r9tC-2f9yA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbq PROBABLE
TRANSCRIPTIONAL
REGULATOR


(Pseudomonas
aeruginosa)
PF00440
(TetR_N)
4 ALA A 148
GLU A  87
ALA A 204
MET A 164
None
1.46A 3r9tC-2fbqA:
undetectable
3r9tC-2fbqA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzf HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus)
PF02915
(Rubrerythrin)
4 ALA A  35
GLU A 147
GLU A 117
ALA A 120
None
1.32A 3r9tC-2fzfA:
undetectable
3r9tC-2fzfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iag PROSTACYCLIN
SYNTHASE


(Homo sapiens)
PF00067
(p450)
4 ALA A 274
GLU A 270
GLU A 271
ALA A 244
None
1.41A 3r9tC-2iagA:
undetectable
3r9tC-2iagA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyz HYPOTHETICAL PROTEIN
GAMMAHV.M3


(Murid
gammaherpesvirus
4)
PF09213
(M3)
4 ALA A  34
GLU A  41
ALA A  40
MET A 155
None
1.35A 3r9tC-2nyzA:
undetectable
3r9tC-2nyzA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9b POSSIBLE PROLIDASE

(Bifidobacterium
longum)
PF01979
(Amidohydro_1)
4 ALA A 190
GLU A 186
ALA A 178
MET A 224
None
1.15A 3r9tC-2p9bA:
undetectable
3r9tC-2p9bA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9p REPLICATION PROTEIN
E1


(Deltapapillomavirus
4)
PF00519
(PPV_E1_C)
4 ALA A 355
GLU A 328
ALA A 332
MET A 316
None
1.47A 3r9tC-2v9pA:
undetectable
3r9tC-2v9pA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN


(Bacteroides
fragilis)
PF00210
(Ferritin)
4 ALA A 117
GLU A  62
GLU A  29
ALA A  32
FE  A6205 ( 4.9A)
FE  A6205 ( 2.5A)
FE  A6204 (-1.9A)
None
1.40A 3r9tC-2vzbA:
undetectable
3r9tC-2vzbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME


(Rattus
norvegicus)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
4 ALA A  61
GLU A 103
GLU A 123
ALA A 132
GOL  A 770 (-4.1A)
GOL  A 770 (-2.9A)
GOL  A 770 ( 3.5A)
GOL  A 770 (-3.8A)
0.37A 3r9tC-2x58A:
20.0
3r9tC-2x58A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvn ASPERGILLUS
FUMIGATUS CHITINASE
A1


(Aspergillus
fumigatus)
PF00704
(Glyco_hydro_18)
4 ALA A 314
GLU A  50
GLU A 318
ALA A 328
None
1.22A 3r9tC-2xvnA:
undetectable
3r9tC-2xvnA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT


(Hydrogenovibrio
marinus)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
4 ALA B 122
GLU B  82
ALA B  80
MET B 165
None
F4S  B 301 ( 4.8A)
None
None
1.45A 3r9tC-3ayxB:
undetectable
3r9tC-3ayxB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133


(Homo sapiens)
no annotation 4 ALA B 951
GLU B 947
ALA B 978
MET B 987
None
1.22A 3r9tC-3cqcB:
undetectable
3r9tC-3cqcB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddd PUTATIVE
ACETYLTRANSFERASE


(Pyrococcus
horikoshii)
PF00583
(Acetyltransf_1)
4 ALA A 199
GLU A 182
GLU A 184
ALA A 181
None
1.39A 3r9tC-3dddA:
undetectable
3r9tC-3dddA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN


(Arabidopsis
thaliana)
PF12697
(Abhydrolase_6)
4 ALA A  40
GLU A  57
ALA A  51
MET A 144
None
1.05A 3r9tC-3dqzA:
2.4
3r9tC-3dqzA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN


(Campylobacter
jejuni)
PF13343
(SBP_bac_6)
4 ALA X 129
GLU X 162
GLU X 126
ALA X 165
None
1.47A 3r9tC-3e13X:
undetectable
3r9tC-3e13X:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvb BACTERIOFERRITIN

(Brucella
abortus)
PF00210
(Ferritin)
4 ALA A  21
GLU A 127
GLU A  94
ALA A  97
IMD  A 171 (-3.4A)
FE  A 164 ( 2.5A)
IMD  A 171 (-3.2A)
IMD  A 171 (-3.4A)
1.31A 3r9tC-3fvbA:
undetectable
3r9tC-3fvbA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvy BACTERIOFERRITIN

(Rhodobacter
sphaeroides)
PF00210
(Ferritin)
4 ALA A  93
GLU A  51
GLU A 127
ALA A  21
None
FE  A 163 (-2.5A)
FE  A 163 (-2.0A)
None
1.43A 3r9tC-3gvyA:
undetectable
3r9tC-3gvyA:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kqf ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN


(Bacillus
anthracis)
PF00378
(ECH_1)
4 ALA A  68
GLU A 116
GLU A 136
ALA A 145
None
0.42A 3r9tC-3kqfA:
28.0
3r9tC-3kqfA:
34.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B


(Legionella
pneumophila)
PF00501
(AMP-binding)
4 ALA A 268
GLU A 534
GLU A 297
MET A 219
None
None
None
1ZZ  A 589 ( 3.9A)
1.09A 3r9tC-3kxwA:
undetectable
3r9tC-3kxwA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lad DIHYDROLIPOAMIDE
DEHYDROGENASE


(Azotobacter
vinelandii)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 ALA A 242
GLU A 262
GLU A 264
ALA A 261
None
1.35A 3r9tC-3ladA:
undetectable
3r9tC-3ladA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3m GLUTATHIONE
S-TRANSFERASE


(Pseudomonas
protegens)
PF00043
(GST_C)
PF13417
(GST_N_3)
4 ALA A 164
GLU A 103
GLU A  98
ALA A 107
None
GSH  A 209 ( 4.9A)
None
None
1.40A 3r9tC-3m3mA:
undetectable
3r9tC-3m3mA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE


(Pseudomonas
aeruginosa)
PF01979
(Amidohydro_1)
4 ALA A 144
GLU A 118
ALA A  59
MET A 108
GOL  A 457 ( 4.2A)
None
None
None
1.41A 3r9tC-3mduA:
undetectable
3r9tC-3mduA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT


(Roseobacter
denitrificans)
PF01039
(Carboxyl_trans)
4 ALA B 461
GLU B 487
GLU B 459
ALA B 465
None
1.30A 3r9tC-3n6rB:
12.9
3r9tC-3n6rB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx3 ACETYLORNITHINE
AMINOTRANSFERASE


(Campylobacter
jejuni)
PF00202
(Aminotran_3)
4 ALA A 197
GLU A 220
ALA A 233
MET A 335
None
1.38A 3r9tC-3nx3A:
undetectable
3r9tC-3nx3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogh PROTEIN YCIE

(Escherichia
coli)
no annotation 4 GLU B 107
GLU B 104
ALA B  21
MET B  28
MG  B 501 ( 2.4A)
FE  B 401 (-2.2A)
MG  B 501 ( 4.5A)
None
1.48A 3r9tC-3oghB:
undetectable
3r9tC-3oghB:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd8 PROBABLE
BACTERIOFERRITIN
BFRB


(Mycobacterium
tuberculosis)
PF00210
(Ferritin)
4 ALA A 167
GLU A 131
GLU A  54
ALA A 170
None
1.36A 3r9tC-3qd8A:
undetectable
3r9tC-3qd8A:
23.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r0o CARNITINYL-COA
DEHYDRATASE


(Mycobacterium
avium)
PF00378
(ECH_1)
4 ALA A  73
GLU A 120
GLU A 140
ALA A 149
None
0.52A 3r9tC-3r0oA:
43.3
3r9tC-3r0oA:
75.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r9s CARNITINYL-COA
DEHYDRATASE


(Mycobacterium
avium)
PF00378
(ECH_1)
5 ALA A  67
GLU A 114
GLU A 134
ALA A 143
MET A 236
BEZ  A 264 ( 3.7A)
BEZ  A 264 (-2.6A)
BEZ  A 264 (-3.3A)
BEZ  A 264 (-3.5A)
None
0.58A 3r9tC-3r9sA:
45.3
3r9tC-3r9sA:
99.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uz0 STAGE III
SPORULATION PROTEIN
AH


(Bacillus
subtilis)
PF12685
(SpoIIIAH)
4 ALA A 141
GLU A 137
GLU A 140
ALA A 133
None
1.43A 3r9tC-3uz0A:
undetectable
3r9tC-3uz0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am2 BACTERIOFERRITIN

(Blastochloris
viridis)
PF00210
(Ferritin)
4 ALA A  93
GLU A  51
GLU A 127
ALA A  21
None
FE  A1161 ( 2.4A)
FE  A1161 ( 2.6A)
None
1.38A 3r9tC-4am2A:
undetectable
3r9tC-4am2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0l AMIDOHYDROLASE

(Brucella
abortus)
PF01979
(Amidohydro_1)
4 ALA A 149
GLU A 123
ALA A  64
MET A 113
None
1.42A 3r9tC-4f0lA:
undetectable
3r9tC-4f0lA:
23.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE


(Escherichia
coli)
PF00378
(ECH_1)
4 ALA A  63
GLU A 109
GLU A 129
ALA A 138
GOL  A 301 ( 4.4A)
GOL  A 301 (-3.8A)
GOL  A 301 (-4.0A)
GOL  A 301 ( 4.6A)
0.68A 3r9tC-4fzwA:
28.8
3r9tC-4fzwA:
37.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gd3 HYDROGENASE-1 SMALL
CHAIN


(Escherichia
coli)
no annotation 4 ALA S 116
GLU S  76
ALA S  74
MET S 156
None
1.41A 3r9tC-4gd3S:
undetectable
3r9tC-4gd3S:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz2 GLUTATHIONE
S-TRANSFERASE DOMAIN


(Xanthobacter
autotrophicus)
PF00043
(GST_C)
PF13417
(GST_N_3)
4 ALA A 163
GLU A 102
GLU A  97
ALA A 106
None
UNL  A 303 ( 4.9A)
None
UNL  A 303 ( 4.1A)
1.34A 3r9tC-4hz2A:
undetectable
3r9tC-4hz2A:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvs ALDEHYDE
DECARBONYLASE


(Prochlorococcus
marinus)
PF11266
(Ald_deCOase)
4 ALA A 131
GLU A  73
GLU A  45
ALA A  48
6NA  A 301 (-3.5A)
FE  A 303 (-2.4A)
FE  A 302 ( 2.4A)
6NA  A 301 (-3.5A)
1.24A 3r9tC-4kvsA:
undetectable
3r9tC-4kvsA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium)
PF05199
(GMC_oxred_C)
4 ALA A 145
GLU A 385
GLU A 146
ALA A 551
None
1.21A 3r9tC-4mifA:
undetectable
3r9tC-4mifA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4poo PUTATIVE RNA
METHYLASE


(Bacillus
subtilis)
PF06962
(rRNA_methylase)
4 ALA A 185
GLU A 187
ALA A  17
MET A 130
None
1.28A 3r9tC-4pooA:
undetectable
3r9tC-4pooA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppm AMINOTRANSFERASE

(Serratia sp.
FS14)
PF00202
(Aminotran_3)
4 ALA A 510
GLU A 508
ALA A 537
MET A 557
None
1.14A 3r9tC-4ppmA:
undetectable
3r9tC-4ppmA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qor CATALASE

(Bacillus
pumilus)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 ALA A  61
GLU A 106
ALA A 243
MET A 194
None
1.36A 3r9tC-4qorA:
undetectable
3r9tC-4qorA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1


(Rhodopseudomonas
palustris)
PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2)
4 ALA A 154
GLU A 158
GLU A 161
ALA A 138
None
1.49A 3r9tC-4r6lA:
undetectable
3r9tC-4r6lA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rc6 ALDEHYDE
DECARBONYLASE


(Synechococcus
elongatus)
PF11266
(Ald_deCOase)
4 ALA B 118
GLU B  60
GLU B  32
ALA B  35
None
FE2  B 301 ( 2.3A)
FE2  B 302 (-2.2A)
FE2  B 301 ( 4.3A)
1.20A 3r9tC-4rc6B:
undetectable
3r9tC-4rc6B:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toc BACTERIOFERRITIN

(Pseudomonas
aeruginosa)
PF00210
(Ferritin)
4 ALA A  97
GLU A  51
GLU A  18
ALA A  21
None
FE2  A 203 ( 2.2A)
FE2  A 203 (-2.1A)
None
1.16A 3r9tC-4tocA:
undetectable
3r9tC-4tocA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE


(Pseudomonas sp.
ADP)
PF01979
(Amidohydro_1)
4 ALA A 153
GLU A 125
ALA A 130
MET A 140
None
1.21A 3r9tC-4v1yA:
undetectable
3r9tC-4v1yA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxw UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
PF00990
(GGDEF)
4 ALA A 414
GLU A 483
GLU A 418
ALA A 480
None
1.16A 3r9tC-4wxwA:
undetectable
3r9tC-4wxwA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4m HYDROGENASE-1 SMALL
CHAIN


(Escherichia
coli)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
4 ALA S 116
GLU S  76
ALA S  74
MET S 156
None
SF3  S 404 ( 4.7A)
None
None
1.42A 3r9tC-5a4mS:
undetectable
3r9tC-5a4mS:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10)
PF00150
(Cellulase)
PF03442
(CBM_X2)
4 ALA A 122
GLU A 119
ALA A  71
MET A  68
None
1.28A 3r9tC-5e0cA:
undetectable
3r9tC-5e0cA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN


(Escherichia
coli;
Homo sapiens)
PF13416
(SBP_bac_8)
4 ALA A 727
GLU A 617
ALA A 643
MET A 669
None
1.31A 3r9tC-5hzwA:
undetectable
3r9tC-5hzwA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE


(Pseudomonas
aeruginosa)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone)
4 ALA A 339
GLU A 338
ALA A 331
MET A 324
None
1.15A 3r9tC-5im3A:
2.2
3r9tC-5im3A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE


(Paraburkholderia
xenovorans)
PF00483
(NTP_transferase)
4 ALA A  48
GLU A  44
ALA A 128
MET A  53
None
1.34A 3r9tC-5j49A:
undetectable
3r9tC-5j49A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE


(Rhizobium
leguminosarum)
PF00920
(ILVD_EDD)
4 ALA A 210
GLU A 214
ALA A 225
MET A 236
None
1.18A 3r9tC-5j84A:
3.5
3r9tC-5j84A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k52 ALDEHYDE
DECARBONYLASE


(Limnothrix sp.
KNUA012)
PF11266
(Ald_deCOase)
4 ALA A 118
GLU A  60
GLU A  32
ALA A  35
OCD  A 500 (-3.6A)
OCD  A 500 (-3.2A)
OCD  A 500 (-3.5A)
OCD  A 500 ( 4.4A)
1.37A 3r9tC-5k52A:
undetectable
3r9tC-5k52A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k53 ALDEHYDE
DEFORMYLATING
OXYGENASE


(Oscillatoria
sp.)
PF11266
(Ald_deCOase)
4 ALA A 118
GLU A  60
GLU A  32
ALA A  35
STE  A 502 ( 3.9A)
FE  A 501 (-2.5A)
FE  A 500 ( 2.3A)
STE  A 502 (-3.5A)
1.29A 3r9tC-5k53A:
undetectable
3r9tC-5k53A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron)
PF13402
(Peptidase_M60)
PF17291
(M60-like_N)
4 ALA A 811
GLU A 813
ALA A 751
MET A 709
None
1.21A 3r9tC-5kd5A:
undetectable
3r9tC-5kd5A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdj UPTAKE HYDROGENASE
SMALL SUBUNIT
HOXK


(Cupriavidus
necator)
no annotation 4 ALA S 116
GLU S  76
ALA S  74
MET S 156
None
F4S  S1003 (-4.1A)
None
None
1.48A 3r9tC-5mdjS:
undetectable
3r9tC-5mdjS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT


(Escherichia
coli)
PF03814
(KdpA)
4 ALA A 459
GLU A 455
ALA A 444
MET A 436
None
1.39A 3r9tC-5mrwA:
undetectable
3r9tC-5mrwA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n3u PHYCOCYANOBILIN
LYASE SUBUNIT ALPHA


(Nostoc sp. PCC
7120)
no annotation 4 ALA A 220
GLU A 113
GLU A 153
ALA A 157
None
1.39A 3r9tC-5n3uA:
undetectable
3r9tC-5n3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tir SUPEROXIDE DISMUTASE

(Trichoderma
reesei)
no annotation 4 ALA A 103
GLU A 194
GLU A 100
ALA A  98
None
1.06A 3r9tC-5tirA:
undetectable
3r9tC-5tirA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux2 ALDEHYDE
DECARBONYLASE


(Synechococcus
sp. RS9917)
no annotation 4 ALA A 112
GLU A  54
GLU A  26
ALA A  29
PPI  A 303 ( 3.7A)
FE  A 301 (-2.5A)
FE  A 302 ( 2.1A)
PPI  A 303 ( 3.7A)
1.30A 3r9tC-5ux2A:
undetectable
3r9tC-5ux2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE


(Pseudomonas
aeruginosa)
no annotation 4 ALA B  78
GLU B 126
GLU B 146
ALA B 155
MRD  B 301 (-3.1A)
MRD  B 301 (-2.8A)
MRD  B 301 (-2.5A)
MRD  B 301 (-4.2A)
0.66A 3r9tC-5wybB:
28.8
3r9tC-5wybB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xf7 PROTEIN
DISULFIDE-ISOMERASE-
LIKE PROTEIN OF THE
TESTIS


(Homo sapiens)
no annotation 4 ALA A  85
GLU A 140
GLU A  81
ALA A 143
None
1.33A 3r9tC-5xf7A:
undetectable
3r9tC-5xf7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoy [LYSW]-LYSINE
HYDROLASE


(Thermus
thermophilus)
PF01546
(Peptidase_M20)
4 ALA A 121
GLU A 148
ALA A  92
MET A  99
None
1.49A 3r9tC-5xoyA:
undetectable
3r9tC-5xoyA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yix RNA POLYMERASE SIGMA
FACTOR RPOD


(Caulobacter
vibrioides)
no annotation 4 ALA A 415
GLU A 411
ALA A 143
MET A 148
None
1.31A 3r9tC-5yixA:
undetectable
3r9tC-5yixA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zrz EPHRIN TYPE-A
RECEPTOR 5


(Mus musculus)
no annotation 4 ALA A 815
GLU A 811
ALA A 805
MET A 833
None
1.10A 3r9tC-5zrzA:
undetectable
3r9tC-5zrzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG


(Escherichia
coli;
Pseudomonas
phage JBD30)
no annotation 4 ALA A  41
GLU A  31
ALA A  18
MET A   1
MES  A 502 (-4.6A)
None
None
PEG  A 509 ( 4.2A)
1.29A 3r9tC-6anvA:
undetectable
3r9tC-6anvA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cy1 SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY


(Elizabethkingia
anophelis)
no annotation 4 ALA A 182
GLU A 217
ALA A 150
MET A 118
None
1.19A 3r9tC-6cy1A:
undetectable
3r9tC-6cy1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv4 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE


(Mycolicibacterium
smegmatis)
no annotation 4 ALA A 213
GLU A 122
ALA A 133
MET A 139
16G  A 402 (-4.6A)
CD  A 403 (-2.4A)
16G  A 402 (-3.8A)
None
1.17A 3r9tC-6fv4A:
undetectable
3r9tC-6fv4A:
undetectable