SIMILAR PATTERNS OF AMINO ACIDS FOR 3R9S_A_BEZA264

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ALA A 225
ILE A 170
LEU A 227
GLU A 166
ALA A 284
 None
 1.14A 3r9sA-1asoA:
undetectable		 3r9sA-1asoA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 ALA A 155
ILE A 206
LEU A 204
GLU A 189
ALA A 193
 None
 1.50A 3r9sA-1c30A:
undetectable		 3r9sA-1c30A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8z TUBBY PROTEIN

(Mus musculus) 		PF01167
(Tub) 		4 ALA A 254
ILE A 328
LEU A 298
GLU A 252
 None
 0.82A 3r9sA-1c8zA:
undetectable		 3r9sA-1c8zA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ALA A 307
ILE A 333
LEU A 181
ALA A 246
 None
 0.91A 3r9sA-1cliA:
undetectable		 3r9sA-1cliA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dc1 BSOBI RESTRICTION
ENDONUCLEASE

(Geobacillus
stearothermophilus) 		PF09194
(Endonuc-BsobI) 		4 ALA A  53
ILE A 111
LEU A  62
ALA A  71
 None
 0.91A 3r9sA-1dc1A:
undetectable		 3r9sA-1dc1A:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dub 2-ENOYL-COA
HYDRATASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 ALA A  98
GLU A 144
GLU A 164
ALA A 173
 CAA  A 300 (-3.6A)
CAA  A 300 ( 3.0A)
CAA  A 300 ( 3.5A)
CAA  A 300 ( 4.7A)
 0.35A 3r9sA-1dubA:
26.5		 3r9sA-1dubA:
36.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		4 ALA A  42
ILE A 312
LEU A  36
ALA A   5
 None
 0.90A 3r9sA-1f26A:
undetectable		 3r9sA-1f26A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g67 THIAMIN PHOSPHATE
SYNTHASE

(Bacillus
subtilis) 		PF02581
(TMP-TENI) 		4 ALA A  75
ILE A  72
LEU A 101
GLU A  60
 None
 0.91A 3r9sA-1g67A:
undetectable		 3r9sA-1g67A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7u 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Escherichia
coli) 		PF00793
(DAHP_synth_1) 		4 ALA A  34
ILE A  80
GLU A 245
GLU A  29
 None
 0.81A 3r9sA-1g7uA:
undetectable		 3r9sA-1g7uA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iok CHAPERONIN 60

(Paracoccus
denitrificans) 		PF00118
(Cpn60_TCP1) 		5 ALA A 106
ILE A 516
LEU A 116
GLU A 102
ALA A 441
 None
 1.37A 3r9sA-1iokA:
undetectable		 3r9sA-1iokA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqc DI-HEME PEROXIDASE

(Nitrosomonas
europaea) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 ALA A 110
ILE A 138
LEU A  31
GLU A 108
ALA A  98
 None
 1.38A 3r9sA-1iqcA:
undetectable		 3r9sA-1iqcA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		4 ALA A 611
ILE A 698
GLU A 613
ALA A  40
 CL  A2002 ( 3.8A)
None
None
None
 0.82A 3r9sA-1itkA:
undetectable		 3r9sA-1itkA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jal YCHF PROTEIN

(Haemophilus
influenzae) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		4 ILE A 178
LEU A 183
GLU A 161
ALA A 190
 None
 0.79A 3r9sA-1jalA:
undetectable		 3r9sA-1jalA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
gordonii) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 ALA A  58
ILE A  17
LEU A  51
GLU A  42
 None
 0.87A 3r9sA-1k20A:
undetectable		 3r9sA-1k20A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kc8 RIBOSOMAL PROTEIN
L18

(Haloarcula
marismortui) 		PF17144
(Ribosomal_L5e) 		4 ALA O 122
ILE O 118
LEU O  34
ALA O  92
 None
 0.88A 3r9sA-1kc8O:
undetectable		 3r9sA-1kc8O:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		4 ILE A 140
LEU A 145
GLU A 156
ALA A 149
 None
 0.87A 3r9sA-1ktnA:
undetectable		 3r9sA-1ktnA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8c CREB-BINDING PROTEIN
HYPOXIA-INDUCIBLE
FACTOR 1 ALPHA

(Mus musculus;
Homo sapiens) 		PF02135
(zf-TAZ)
PF08778
(HIF-1a_CTAD) 		4 ILE A   9
LEU B 118
GLU B 124
ALA A  65
 None
 0.90A 3r9sA-1l8cA:
undetectable		 3r9sA-1l8cA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		4 ALA A 168
ILE A 256
LEU A 286
ALA A 139
 None
 0.78A 3r9sA-1l8wA:
undetectable		 3r9sA-1l8wA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 ALA A 422
ILE A 426
LEU A 455
ALA A 462
 None
 0.89A 3r9sA-1lf9A:
undetectable		 3r9sA-1lf9A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		4 ILE A 286
LEU A 334
GLU A  85
ALA A  83
 None
 0.79A 3r9sA-1nbwA:
undetectable		 3r9sA-1nbwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Haemophilus
influenzae) 		PF00793
(DAHP_synth_1) 		4 ILE A 163
LEU A 165
GLU A 153
ALA A 190
 None
 0.83A 3r9sA-1o60A:
undetectable		 3r9sA-1o60A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or7 RNA POLYMERASE
SIGMA-E FACTOR

(Escherichia
coli) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2) 		4 ALA A 177
ILE A 181
LEU A 138
ALA A 145
 None
 0.85A 3r9sA-1or7A:
undetectable		 3r9sA-1or7A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		4 ALA A  74
ILE A 121
LEU A  80
GLU A  70
 None
 0.74A 3r9sA-1qbgA:
undetectable		 3r9sA-1qbgA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s70 130 KDA
MYOSIN-BINDING
SUBUNIT OF SMOOTH
MUSCLE MYOSIN
PHOPHATASE (M130)

(Gallus gallus) 		PF12796
(Ank_2) 		5 ALA B 122
ILE B 126
LEU B 110
GLU B 148
ALA B 146
 None
 1.28A 3r9sA-1s70B:
undetectable		 3r9sA-1s70B:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq1 CHORISMATE SYNTHASE

(Campylobacter
jejuni) 		PF01264
(Chorismate_synt) 		4 ALA A 334
LEU A 338
GLU A  42
ALA A 139
 None
 0.91A 3r9sA-1sq1A:
undetectable		 3r9sA-1sq1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Mycobacterium
tuberculosis) 		PF01513
(NAD_kinase) 		5 ILE A 264
LEU A 163
GLU A 177
GLU A 244
ALA A 242
 None
 1.35A 3r9sA-1u0tA:
undetectable		 3r9sA-1u0tA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpb PUTATIVE MODULATOR
OF DNA GYRASE

(Bacteroides
thetaiotaomicron) 		PF01523
(PmbA_TldD) 		4 ALA A 140
ILE A 147
LEU A 218
ALA A 182
 None
 0.75A 3r9sA-1vpbA:
undetectable		 3r9sA-1vpbA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn0 HISTIDINE-CONTAINING
PHOSPHOTRANSFER
PROTEIN

(Zea mays) 		PF01627
(Hpt) 		4 ALA A  54
ILE A  58
LEU A  82
ALA A  91
 None
 0.83A 3r9sA-1wn0A:
undetectable		 3r9sA-1wn0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ILE A 516
LEU A 503
GLU A 509
ALA A 736
 None
 0.87A 3r9sA-1x9nA:
undetectable		 3r9sA-1x9nA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg5 ARPG836

(Homo sapiens) 		PF00106
(adh_short) 		4 ALA A  28
ILE A  48
LEU A  64
ALA A  14
 None
 0.75A 3r9sA-1xg5A:
undetectable		 3r9sA-1xg5A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xip NUCLEOPORIN NUP159

(Saccharomyces
cerevisiae) 		PF16755
(NUP214) 		4 ALA A  53
ILE A  26
LEU A 368
ALA A 340
 None
 0.89A 3r9sA-1xipA:
undetectable		 3r9sA-1xipA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yuz NIGERYTHRIN

(Desulfovibrio
vulgaris) 		PF02915
(Rubrerythrin) 		5 ALA A  72
ILE A 180
GLU A  40
GLU A 149
ALA A  43
 None
None
FE  A 301 (-1.9A)
FE  A 301 ( 2.5A)
FE  A 301 ( 4.6A)
 1.33A 3r9sA-1yuzA:
undetectable		 3r9sA-1yuzA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db5 INAD-LIKE PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 ALA A  96
ILE A  82
LEU A  87
ALA A  45
 None
 0.84A 3r9sA-2db5A:
undetectable		 3r9sA-2db5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgj HYPOTHETICAL PROTEIN
EBHA

(Staphylococcus
aureus) 		PF01468
(GA) 		4 ALA A 122
ILE A  94
LEU A 102
ALA A  84
 None
 0.77A 3r9sA-2dgjA:
undetectable		 3r9sA-2dgjA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		4 ALA A 329
ILE A 325
LEU A 307
ALA A 360
 None
 0.83A 3r9sA-2e0wA:
undetectable		 3r9sA-2e0wA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE

(Archaeoglobus
fulgidus) 		PF01884
(PcrB) 		5 ALA A1148
ILE A1166
LEU A1127
GLU A1146
GLU A1180
 None
 1.23A 3r9sA-2f6xA:
2.3		 3r9sA-2f6xA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ALA A 118
ILE A 133
LEU A 348
ALA A  34
 None
 0.90A 3r9sA-2fymA:
undetectable		 3r9sA-2fymA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ALA A  75
ILE A  51
LEU A  14
GLU A 297
 None
 0.82A 3r9sA-2g76A:
undetectable		 3r9sA-2g76A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2giy GLYCOPROTEIN E

(Human
alphaherpesvirus
1) 		PF02480
(Herpes_gE) 		4 ALA A 384
ILE A 276
LEU A 356
ALA A 231
 None
 0.66A 3r9sA-2giyA:
undetectable		 3r9sA-2giyA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj7 GLYCOPROTEIN E

(Human
alphaherpesvirus
1) 		no annotation 4 ALA F 384
ILE F 276
LEU F 356
ALA F 231
 None
 0.65A 3r9sA-2gj7F:
undetectable		 3r9sA-2gj7F:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h27 RNA POLYMERASE SIGMA
E FACTOR

(Escherichia
coli) 		PF08281
(Sigma70_r4_2) 		4 ALA A 177
ILE A 181
LEU A 138
ALA A 145
 None
 0.87A 3r9sA-2h27A:
undetectable		 3r9sA-2h27A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoe N-ACETYLGLUCOSAMINE
KINASE

(Thermotoga
maritima) 		PF00480
(ROK) 		5 ALA A  89
ILE A 122
LEU A  78
GLU A  81
ALA A 353
 None
 1.10A 3r9sA-2hoeA:
undetectable		 3r9sA-2hoeA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE

(Bacillus
halodurans) 		PF02608
(Bmp) 		4 ALA A  46
ILE A  50
LEU A   5
ALA A  67
 None
 0.69A 3r9sA-2hqbA:
2.8		 3r9sA-2hqbA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE

(Bacillus
halodurans) 		PF02608
(Bmp) 		4 ALA A  46
ILE A  50
LEU A   5
GLU A  43
 None
 0.91A 3r9sA-2hqbA:
2.8		 3r9sA-2hqbA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxg L-ARABINOSE
ISOMERASE

(Escherichia
coli) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		4 ALA A 313
ILE A 317
LEU A 176
ALA A 198
 None
 0.91A 3r9sA-2hxgA:
3.6		 3r9sA-2hxgA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id0 EXORIBONUCLEASE 2

(Escherichia
coli) 		PF00575
(S1)
PF00773
(RNB)
PF08206
(OB_RNB) 		4 ALA A  62
ILE A  60
LEU A  36
GLU A  74
 None
 0.83A 3r9sA-2id0A:
undetectable		 3r9sA-2id0A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irw CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1

(Homo sapiens) 		PF00106
(adh_short) 		4 ILE A 245
LEU A 215
GLU A 240
ALA A 236
 None
NAP  A 901 (-4.1A)
None
None
 0.83A 3r9sA-2irwA:
undetectable		 3r9sA-2irwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obn HYPOTHETICAL PROTEIN

(Trichormus
variabilis) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		4 ILE A  40
LEU A  76
GLU A  66
ALA A 101
 None
 0.85A 3r9sA-2obnA:
undetectable		 3r9sA-2obnA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omd MOLYBDOPTERIN-CONVER
TING FACTOR SUBUNIT
2

(Aquifex
aeolicus) 		PF02391
(MoaE) 		4 ALA A  63
ILE A 128
LEU A  11
GLU A  66
 None
 0.89A 3r9sA-2omdA:
undetectable		 3r9sA-2omdA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00483
(NTP_transferase) 		5 ALA A 107
ILE A  63
LEU A  61
GLU A  77
ALA A 102
 None
 1.49A 3r9sA-2pa4A:
undetectable		 3r9sA-2pa4A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwz MALATE DEHYDROGENASE

(Escherichia
coli) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ALA A 128
ILE A 116
LEU A 143
ALA A 106
 None
 0.70A 3r9sA-2pwzA:
undetectable		 3r9sA-2pwzA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 ALA A 531
ILE A 579
LEU A 583
ALA A 549
 None
 0.86A 3r9sA-2q1fA:
undetectable		 3r9sA-2q1fA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4f HISTIDINE-CONTAINING
PHOSPHOTRANSFER
PROTEIN 1

(Oryza sativa) 		PF01627
(Hpt) 		4 ALA A  54
ILE A  58
LEU A  82
ALA A  91
 None
 0.87A 3r9sA-2q4fA:
undetectable		 3r9sA-2q4fA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE

(Azospirillum
brasilense) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ALA A 141
ILE A 145
LEU A 135
ALA A 170
 None
 0.63A 3r9sA-2q5oA:
undetectable		 3r9sA-2q5oA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		4 ALA A 277
ILE A 294
LEU A 250
ALA A 314
 None
 0.91A 3r9sA-2qfqA:
undetectable		 3r9sA-2qfqA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz4 PARAPLEGIN

(Homo sapiens) 		PF00004
(AAA) 		5 ALA A 548
ILE A 524
LEU A 509
GLU A 546
GLU A 550
 None
 1.36A 3r9sA-2qz4A:
undetectable		 3r9sA-2qz4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		4 ALA A  21
ILE A 127
LEU A  34
GLU A  19
 None
 0.76A 3r9sA-2rmpA:
undetectable		 3r9sA-2rmpA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v28 PHENYLALANINE-4-HYDR
OXYLASE

(Colwellia
psychrerythraea) 		PF00351
(Biopterin_H) 		4 ALA A 194
ILE A 179
LEU A 170
GLU A 190
 None
 0.81A 3r9sA-2v28A:
undetectable		 3r9sA-2v28A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ALA A 142
ILE A 146
LEU A 137
ALA A 171
 ALA  A 142 ( 0.0A)
ILE  A 146 ( 0.7A)
LEU  A 137 ( 0.6A)
ALA  A 171 ( 0.0A)
 0.78A 3r9sA-2vbfA:
undetectable		 3r9sA-2vbfA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd9 ALANINE RACEMASE

(Bacillus
anthracis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ALA A  53
ILE A  80
LEU A  64
ALA A  44
 MLY  A  54 ( 3.0A)
None
None
None
 0.89A 3r9sA-2vd9A:
undetectable		 3r9sA-2vd9A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf1 CAPSID PROTEIN

(Rabbit
picobirnavirus) 		no annotation 4 ALA A 178
ILE A 236
LEU A 313
ALA A 319
 None
 0.91A 3r9sA-2vf1A:
undetectable		 3r9sA-2vf1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		4 ALA A 110
ILE A 107
LEU A 111
ALA A  97
 None
 0.90A 3r9sA-2vhlA:
1.0		 3r9sA-2vhlA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjg FERROUS IRON
TRANSPORT PROTEIN B
HOMOLOG

(Methanocaldococcus
jannaschii) 		PF02421
(FeoB_N) 		4 ALA A 114
ILE A  19
LEU A 144
ALA A 158
 None
 0.63A 3r9sA-2wjgA:
2.2		 3r9sA-2wjgA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wji FERROUS IRON
TRANSPORT PROTEIN B
HOMOLOG

(Methanocaldococcus
jannaschii) 		PF02421
(FeoB_N) 		4 ALA A 114
ILE A  19
LEU A 144
ALA A 158
 None
 0.63A 3r9sA-2wjiA:
undetectable		 3r9sA-2wjiA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 ALA A  61
GLU A 103
GLU A 123
ALA A 132
 GOL  A 770 (-4.1A)
GOL  A 770 (-2.9A)
GOL  A 770 ( 3.5A)
GOL  A 770 (-3.8A)
 0.31A 3r9sA-2x58A:
19.6		 3r9sA-2x58A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrm INTRACELLULAR
SUBTILISIN PROTEASE

(Bacillus
clausii) 		PF00082
(Peptidase_S8) 		4 ALA A 259
ILE A 263
LEU A 305
ALA A 229
 None
 0.90A 3r9sA-2xrmA:
3.2		 3r9sA-2xrmA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2w ARABINOFURANOSIDASE

(Bifidobacterium
longum) 		PF06964
(Alpha-L-AF_C) 		5 ALA A 515
ILE A 542
LEU A 540
GLU A 436
GLU A 563
 None
 1.48A 3r9sA-2y2wA:
undetectable		 3r9sA-2y2wA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5j DIHYDROPTEROATE
SYNTHASE

(Burkholderia
cenocepacia) 		PF00809
(Pterin_bind) 		4 ALA A  50
ILE A  54
LEU A  61
ALA A  90
 None
 0.83A 3r9sA-2y5jA:
undetectable		 3r9sA-2y5jA:
27.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		4 ALA A  51
ILE A 317
LEU A  45
ALA A  13
 None
 0.88A 3r9sA-2zbzA:
undetectable		 3r9sA-2zbzA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ALA A 155
ILE A 196
LEU A 210
ALA A  43
 None
 0.79A 3r9sA-3a8kA:
undetectable		 3r9sA-3a8kA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4t RIBONUCLEASE PH

(Mycobacterium
tuberculosis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 ALA A 134
ILE A  95
LEU A  99
ALA A  42
 None
 0.82A 3r9sA-3b4tA:
undetectable		 3r9sA-3b4tA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli) 		PF01343
(Peptidase_S49) 		4 ALA A 333
ILE A 385
LEU A 370
ALA A 407
 None
 0.84A 3r9sA-3bf0A:
12.5		 3r9sA-3bf0A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw2 2-NITROPROPANE
DIOXYGENASE

(Streptomyces
ansochromogenes) 		PF03060
(NMO) 		4 ALA A 213
ILE A 217
LEU A 196
ALA A 229
 None
 0.77A 3r9sA-3bw2A:
undetectable		 3r9sA-3bw2A:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ALA A 160
ILE A 153
LEU A 141
ALA A  91
 None
 0.88A 3r9sA-3ce6A:
undetectable		 3r9sA-3ce6A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgg SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		4 ALA A 142
ILE A 132
LEU A 166
ALA A 189
 None
NHE  A 195 ( 4.9A)
None
None
 0.89A 3r9sA-3cggA:
undetectable		 3r9sA-3cggA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3b 30S RIBOSOMAL
PROTEIN S10

(Escherichia
coli) 		PF00338
(Ribosomal_S10) 		4 ALA J  21
ILE J  25
LEU J  71
ALA J  12
 None
 0.82A 3r9sA-3d3bJ:
undetectable		 3r9sA-3d3bJ:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddh PUTATIVE HALOACID
DEHALOGENASE-LIKE
FAMILY HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		4 ALA A  73
ILE A  89
LEU A  34
ALA A  46
 None
 0.87A 3r9sA-3ddhA:
undetectable		 3r9sA-3ddhA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3del ARGININE BINDING
PROTEIN

(Chlamydia
trachomatis) 		PF00497
(SBP_bac_3) 		4 ALA B  64
ILE B  61
LEU B  75
ALA B  96
 None
 0.79A 3r9sA-3delB:
undetectable		 3r9sA-3delB:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dms ISOCITRATE
DEHYDROGENASE [NADP]

(Burkholderia
pseudomallei) 		PF00180
(Iso_dh) 		4 ALA A  72
ILE A  34
LEU A 105
ALA A 119
 None
 0.91A 3r9sA-3dmsA:
undetectable		 3r9sA-3dmsA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ALA A 194
ILE A 177
LEU A 248
ALA A  90
 None
 0.90A 3r9sA-3e60A:
undetectable		 3r9sA-3e60A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ALA A 170
ILE A 168
LEU A 197
ALA A  95
 None
 0.77A 3r9sA-3fhhA:
undetectable		 3r9sA-3fhhA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwy LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN

(Rhodobacter
sphaeroides) 		PF00142
(Fer4_NifH) 		4 ALA A 262
ILE A 240
LEU A 250
GLU A 265
 None
ADP  A 501 (-3.6A)
None
None
 0.90A 3r9sA-3fwyA:
undetectable		 3r9sA-3fwyA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5l PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Ruegeria
pomeroyi) 		PF13458
(Peripla_BP_6) 		4 ALA A 103
ILE A 107
LEU A 115
ALA A 126
 None
 0.78A 3r9sA-3h5lA:
undetectable		 3r9sA-3h5lA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9p PUTATIVE
TRIPHOSPHORIBOSYL-DE
PHOSPHO-COA SYNTHASE

(Archaeoglobus
fulgidus) 		PF01874
(CitG) 		5 ALA A 107
ILE A 185
LEU A 269
GLU A 108
ALA A 100
 None
 1.29A 3r9sA-3h9pA:
undetectable		 3r9sA-3h9pA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ALA A 310
ILE A 316
LEU A 292
ALA A 244
 None
 0.90A 3r9sA-3hkoA:
undetectable		 3r9sA-3hkoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Pyrococcus
furiosus) 		PF07969
(Amidohydro_3) 		4 ALA A 265
ILE A 290
LEU A 267
ALA A 246
 None
 0.78A 3r9sA-3icjA:
3.0		 3r9sA-3icjA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuk UNCHARACTERIZED
PROTEIN

(Paenarthrobacter
aurescens) 		PF05960
(DUF885) 		4 ALA A 160
ILE A 165
LEU A 104
ALA A 153
 None
 0.86A 3r9sA-3iukA:
undetectable		 3r9sA-3iukA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kds CELL DIVISION
PROTEIN FTSH

(Thermotoga
maritima) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		4 ALA E 428
ILE E 582
LEU E 597
GLU E 424
 None
None
None
NHX  E 998 (-3.0A)
 0.83A 3r9sA-3kdsE:
undetectable		 3r9sA-3kdsE:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 ALA A 232
ILE A 260
LEU A 278
ALA A 309
 None
 0.65A 3r9sA-3kehA:
undetectable		 3r9sA-3kehA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kew DHHA1 DOMAIN PROTEIN

(Clostridium
perfringens) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 ALA A 144
ILE A 148
LEU A 101
GLU A 141
 None
 0.90A 3r9sA-3kewA:
undetectable		 3r9sA-3kewA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgl CRUCIFERIN

(Brassica napus) 		PF00190
(Cupin_1) 		4 ALA A 156
ILE A 317
LEU A 321
ALA A 325
 None
 0.89A 3r9sA-3kglA:
undetectable		 3r9sA-3kglA:
18.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kqf ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00378
(ECH_1) 		4 ALA A  68
GLU A 116
GLU A 136
ALA A 145
 None
 0.40A 3r9sA-3kqfA:
28.1		 3r9sA-3kqfA:
34.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kre PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Ehrlichia
chaffeensis) 		PF01259
(SAICAR_synt) 		4 ILE A 151
LEU A 191
GLU A 179
ALA A 194
 None
 0.89A 3r9sA-3kreA:
undetectable		 3r9sA-3kreA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		4 ILE A 538
LEU A 540
GLU A 522
ALA A 515
 None
 0.85A 3r9sA-3kxwA:
undetectable		 3r9sA-3kxwA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 ALA A 429
ILE A 411
LEU A 256
GLU A  93
 None
 0.83A 3r9sA-3lq1A:
undetectable		 3r9sA-3lq1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2t PROBABLE
DEHYDROGENASE

(Chromobacterium
violaceum) 		PF01408
(GFO_IDH_MocA) 		4 ALA A 185
ILE A 150
LEU A 152
ALA A 211
 None
 0.88A 3r9sA-3m2tA:
undetectable		 3r9sA-3m2tA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 ALA A 339
ILE A 352
GLU A 605
ALA A 578
 None
 0.87A 3r9sA-3mi6A:
undetectable		 3r9sA-3mi6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvg RIBOSOME
INACTIVATING TYPE 1
PROTEIN

(Iris x
hollandica) 		PF00161
(RIP) 		5 ALA A 167
ILE A 194
LEU A 197
GLU A 169
ALA A 245
 GOL  A 280 ( 4.0A)
None
GOL  A 280 ( 4.0A)
None
None
 1.45A 3r9sA-3mvgA:
undetectable		 3r9sA-3mvgA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n26 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Chlamydia
pneumoniae) 		PF00497
(SBP_bac_3) 		4 ALA A  61
ILE A  58
LEU A  72
ALA A  93
 None
 0.87A 3r9sA-3n26A:
undetectable		 3r9sA-3n26A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 ALA A  31
ILE A 270
LEU A  18
GLU A  30
ALA A  58
 None
 1.25A 3r9sA-3o3rA:
2.0		 3r9sA-3o3rA:
22.38