SIMILAR PATTERNS OF AMINO ACIDS FOR 3R9C_A_ECLA452

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aos ARGININOSUCCINATE
LYASE

(Homo sapiens) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 SER A 175
LEU A 253
LEU A 180
ALA A 346
THR A 347
 None
 1.17A 3r9cA-1aosA:
undetectable		 3r9cA-1aosA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cij PROTEIN (HALOALKANE
DEHALOGENASE)

(Xanthobacter
autotrophicus) 		PF00561
(Abhydrolase_1) 		5 ALA A 108
LEU A 106
LEU A  53
LEU A 120
LEU A 115
 None
 1.19A 3r9cA-1cijA:
0.0		 3r9cA-1cijA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		5 ALA A 206
LEU A  49
LEU A 487
LEU A 451
LEU A 326
 None
 1.19A 3r9cA-1f0iA:
0.0		 3r9cA-1f0iA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f59 IMPORTIN BETA-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 ALA A 176
ALA A 194
THR A 195
LEU A 198
LEU A 241
 None
 1.05A 3r9cA-1f59A:
1.4		 3r9cA-1f59A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		5 PRO A 102
LEU A  88
LEU A  84
ALA A 108
THR A 109
 None
 1.18A 3r9cA-1h79A:
undetectable		 3r9cA-1h79A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jih DNA POLYMERASE ETA

(Saccharomyces
cerevisiae) 		PF00817
(IMS)
PF11799
(IMS_C) 		5 PRO A 206
LEU A 205
LEU A   9
LEU A 169
ASN A 189
 None
 1.04A 3r9cA-1jihA:
undetectable		 3r9cA-1jihA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khy CLPB PROTEIN

(Escherichia
coli) 		PF02861
(Clp_N) 		5 ALA A  37
LEU A  39
LEU A  60
LEU A 126
LEU A  32
 None
 1.13A 3r9cA-1khyA:
0.0		 3r9cA-1khyA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 LEU A  60
ALA A  56
ASN A  55
LEU A  54
LEU A  41
 None
 1.12A 3r9cA-1p88A:
0.0		 3r9cA-1p88A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 CYTOCHROME B6-F
COMPLEX IRON-SULFUR
SUBUNIT

(Chlamydomonas
reinhardtii) 		PF00355
(Rieske) 		5 PRO C 114
LEU C 106
ALA C 132
ASN C 131
LEU C 130
 None
 0.90A 3r9cA-1q90C:
undetectable		 3r9cA-1q90C:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 ALA A 176
ALA A 194
THR A 195
LEU A 198
LEU A 241
 None
 1.03A 3r9cA-1qgrA:
0.0		 3r9cA-1qgrA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT

(Salmonella
enterica) 		PF01791
(DeoC) 		5 PRO A 197
LEU A 198
ALA A 210
THR A 209
LEU A 208
 None
 1.02A 3r9cA-1to3A:
undetectable		 3r9cA-1to3A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpv HYPOTHETICAL PROTEIN
XCC2852

(Xanthomonas
campestris) 		PF05768
(DUF836) 		5 ALA A  28
LEU A   3
LEU A  51
LEU A  68
ALA A  26
 None
 0.87A 3r9cA-1xpvA:
undetectable		 3r9cA-1xpvA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybi NON-TOXIN
HAEMAGGLUTININ HA34

(Clostridium
botulinum) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		5 ALA A 274
THR A 273
ASN A 178
LEU A 179
LEU A 161
 None
 1.18A 3r9cA-1ybiA:
undetectable		 3r9cA-1ybiA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf0 PCF11

(Saccharomyces
cerevisiae) 		no annotation 5 LEU X  30
LEU X  16
ALA X  66
LEU X  67
LEU X  89
 None
 1.19A 3r9cA-2bf0X:
undetectable		 3r9cA-2bf0X:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9f ARGININOSUCCINATE
LYASE

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 ALA A 299
LEU A 252
LEU A 342
ASN A 246
LEU A 245
 None
 1.00A 3r9cA-2e9fA:
undetectable		 3r9cA-2e9fA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		5 LEU A 222
ALA A 377
THR A 378
ASN A 380
LEU A 237
 None
 1.19A 3r9cA-2f5uA:
undetectable		 3r9cA-2f5uA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv8 RHO-RELATED
GTP-BINDING PROTEIN
RHOB

(Homo sapiens) 		PF00071
(Ras) 		5 LEU A  81
LEU A  55
VAL A  53
ALA A 174
THR A 175
 None
 0.95A 3r9cA-2fv8A:
undetectable		 3r9cA-2fv8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		5 LEU A  62
VAL A  60
ALA A  47
ASN A  48
LEU A  49
 None
 0.83A 3r9cA-2iuyA:
undetectable		 3r9cA-2iuyA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojh UNCHARACTERIZED
PROTEIN
ATU1656/AGR_C_3050

(Agrobacterium
fabrum) 		PF07676
(PD40) 		5 PRO A  45
LEU A  54
LEU A  67
ALA A 285
ASN A 276
 None
 1.10A 3r9cA-2ojhA:
undetectable		 3r9cA-2ojhA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otm HYPOTHETICAL PROTEIN

(Shewanella
oneidensis) 		PF14588
(YjgF_endoribonc) 		5 LEU A  79
LEU A 119
ALA A  75
THR A  72
LEU A  73
 None
 0.86A 3r9cA-2otmA:
undetectable		 3r9cA-2otmA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfz PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03480
(DctP) 		6 LEU A 212
LEU A 107
LEU A 103
ALA A 210
ASN A 209
LEU A  79
 None
 1.43A 3r9cA-2pfzA:
undetectable		 3r9cA-2pfzA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcw BONE MORPHOGENETIC
PROTEIN 6

(Homo sapiens) 		PF00019
(TGF_beta) 		5 ALA A  70
LEU A  68
ALA A  74
THR A  75
ASN A  73
 None
 1.16A 3r9cA-2qcwA:
undetectable		 3r9cA-2qcwA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A  50
LEU A  36
LEU A  38
LEU A 111
LEU A 126
 None
 1.12A 3r9cA-2qdeA:
undetectable		 3r9cA-2qdeA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		5 ALA A 176
ALA A 194
THR A 195
LEU A 198
LEU A 241
 None
 1.02A 3r9cA-2qnaA:
undetectable		 3r9cA-2qnaA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F

(Enterococcus
faecium) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		5 LEU A  51
VAL A  68
ALA A  61
ASN A  60
LEU A  41
 None
 1.08A 3r9cA-2qr4A:
undetectable		 3r9cA-2qr4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE

(Mycoplasma
pneumoniae) 		PF00579
(tRNA-synt_1b) 		5 LEU A 257
ALA A 292
THR A 293
ASN A 295
LEU A 296
 None
 0.76A 3r9cA-2yy5A:
undetectable		 3r9cA-2yy5A:
23.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		5 ALA A 268
LEU A 270
LEU A 369
LEU A 261
LEU A 402
 None
 1.15A 3r9cA-2zbzA:
41.9		 3r9cA-2zbzA:
35.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9n ALKANE MONOOXYGENASE

(Geobacillus
thermodenitrificans) 		PF00296
(Bac_luciferase) 		5 ALA A  53
LEU A  46
VAL A 283
ALA A   9
ASN A   8
 None
 0.98A 3r9cA-3b9nA:
undetectable		 3r9cA-3b9nA:
22.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3buj CALO2

(Micromonospora
echinospora) 		PF00067
(p450) 		5 SER A 248
ALA A 358
LEU A 360
ALA A 356
LEU A 353
 None
 0.73A 3r9cA-3bujA:
44.3		 3r9cA-3bujA:
33.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjw COUP TRANSCRIPTION
FACTOR 2

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 257
LEU A 386
ALA A 216
LEU A 220
LEU A 395
 None
 1.11A 3r9cA-3cjwA:
undetectable		 3r9cA-3cjwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 LEU A 381
ALA A 313
THR A 312
ASN A 316
LEU A 262
 None
 1.14A 3r9cA-3dwbA:
0.8		 3r9cA-3dwbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4

(Schizosaccharomyces
pombe) 		PF05856
(ARPC4) 		5 ALA F  21
LEU F  51
VAL F  53
THR F  15
LEU F  16
 None
 0.93A 3r9cA-3dwlF:
undetectable		 3r9cA-3dwlF:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19

(Rhodobacter
sphaeroides) 		PF01244
(Peptidase_M19) 		5 LEU A 244
LEU A 249
ASN A 262
LEU A 261
LEU A 340
 None
 1.13A 3r9cA-3fdgA:
undetectable		 3r9cA-3fdgA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8y SUSD/RAGB-ASSOCIATED
ESTERASE-LIKE
PROTEIN

(Bacteroides
vulgatus) 		PF12715
(Abhydrolase_7) 		5 ALA A 193
LEU A 217
ALA A 191
ASN A 190
LEU A 309
 None
 1.15A 3r9cA-3g8yA:
undetectable		 3r9cA-3g8yA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE

(Pseudomonas
putida) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 307
LEU A 309
ALA A 303
THR A 300
LEU A 301
 None
 0.94A 3r9cA-3h8fA:
undetectable		 3r9cA-3h8fA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL

(Homo sapiens) 		PF04775
(Bile_Hydr_Trans)
PF08840
(BAAT_C) 		5 PRO A 213
LEU A 212
LEU A 210
LEU A 277
LEU A 290
 None
 0.94A 3r9cA-3hlkA:
undetectable		 3r9cA-3hlkA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn1 GOLGI PHOSPHOPROTEIN
3

(Homo sapiens) 		PF05719
(GPP34) 		5 LEU A 103
LEU A  94
ALA A 136
LEU A 133
LEU A  62
 None
 1.00A 3r9cA-3kn1A:
undetectable		 3r9cA-3kn1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus) 		PF00291
(PALP) 		5 LEU A  67
LEU A  91
ALA A  63
ASN A  62
LEU A  61
 None
 0.94A 3r9cA-3l6cA:
undetectable		 3r9cA-3l6cA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o53 PROTEIN LRIM1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 ALA A 184
LEU A 186
LEU A 196
LEU A 198
ASN A 182
 None
 0.80A 3r9cA-3o53A:
undetectable		 3r9cA-3o53A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1

(Anopheles
gambiae) 		PF00560
(LRR_1) 		5 ALA A 184
LEU A 186
LEU A 196
LEU A 198
ASN A 182
 None
 0.81A 3r9cA-3ojaA:
undetectable		 3r9cA-3ojaA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0u NUCLEAR RECEPTOR
SUBFAMILY 2 GROUP C
MEMBER 2

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 512
LEU A 514
LEU A 566
LEU A 569
LEU A 445
 None
 1.16A 3r9cA-3p0uA:
undetectable		 3r9cA-3p0uA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnt IMMUNITY FACTOR FOR
SPN

(Streptococcus
pyogenes) 		PF16718
(IFS) 		5 LEU B 102
ALA B  98
THR B  95
ASN B  97
LEU B  96
 None
 0.66A 3r9cA-3pntB:
undetectable		 3r9cA-3pntB:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 LEU A 888
LEU A 733
ALA A 892
ASN A 893
LEU A 894
 None
 0.84A 3r9cA-3psfA:
undetectable		 3r9cA-3psfA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 LEU A 888
LEU A 733
ALA A 892
ASN A 893
LEU A 894
 None
 0.84A 3r9cA-3psiA:
undetectable		 3r9cA-3psiA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9v DNA-BINDING RESPONSE
REGULATOR

(Deinococcus
radiodurans) 		PF00486
(Trans_reg_C) 		5 ALA A 198
LEU A 196
LEU A 157
LEU A 131
LEU A 203
 None
 1.15A 3r9cA-3q9vA:
undetectable		 3r9cA-3q9vA:
17.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r9b CYTOCHROME P450
164A2

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		7 LEU A 100
LEU A 108
VAL A 112
ALA A 248
THR A 249
ASN A 251
LEU A 252
 None
None
None
None
None
None
HEM  A 501 ( 4.5A)
 0.93A 3r9cA-3r9bA:
62.5		 3r9cA-3r9bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r9b CYTOCHROME P450
164A2

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		8 SER A  71
LEU A 108
VAL A 112
ALA A 248
THR A 249
ASN A 251
LEU A 252
LEU A 367
 None
None
None
None
None
None
HEM  A 501 ( 4.5A)
HEM  A 501 ( 4.3A)
 0.75A 3r9cA-3r9bA:
62.5		 3r9cA-3r9bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r9b CYTOCHROME P450
164A2

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		5 SER A  71
PRO A  94
VAL A 112
THR A 249
LEU A 367
 None
None
None
None
HEM  A 501 ( 4.3A)
 0.83A 3r9cA-3r9bA:
62.5		 3r9cA-3r9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 LEU A 356
LEU A 316
LEU A 337
VAL A 371
LEU A 224
 None
 1.12A 3r9cA-3t3oA:
undetectable		 3r9cA-3t3oA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 PRO A 537
ALA A 542
VAL A 558
ASN A 549
LEU A 550
 None
 1.18A 3r9cA-3ttfA:
undetectable		 3r9cA-3ttfA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 LEU A  50
LEU A  15
ALA A  46
ASN A  45
LEU A  44
 None
 1.06A 3r9cA-3u95A:
undetectable		 3r9cA-3u95A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umg HALOACID
DEHALOGENASE

(Rhodococcus
jostii) 		PF00702
(Hydrolase) 		5 LEU A 242
LEU A 246
ALA A 192
LEU A  19
LEU A 184
 None
 1.09A 3r9cA-3umgA:
0.9		 3r9cA-3umgA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		5 LEU A  97
LEU A 293
LEU A 287
ALA A  93
THR A  90
 None
 0.95A 3r9cA-3wwxA:
undetectable		 3r9cA-3wwxA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyf PANTETHEINASE

(Homo sapiens) 		PF00795
(CN_hydrolase) 		5 SER A 265
LEU A 301
LEU A 299
ALA A  72
LEU A 127
 None
None
None
None
NAG  A 601 ( 4.4A)
 0.86A 3r9cA-4cyfA:
undetectable		 3r9cA-4cyfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efh ACTIN-1

(Acanthamoeba
castellanii) 		PF00022
(Actin) 		5 LEU A 178
LEU A 153
VAL A 297
THR A 278
ASN A 280
 None
 0.87A 3r9cA-4efhA:
undetectable		 3r9cA-4efhA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		5 PRO A 397
LEU A 378
LEU A 404
ALA A 418
LEU A 420
 None
 1.15A 3r9cA-4fqdA:
undetectable		 3r9cA-4fqdA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h18 CMT1

(Corynebacterium
glutamicum) 		PF00756
(Esterase) 		5 ALA A 186
ALA A 192
THR A 193
LEU A 196
LEU A 256
 None
 1.11A 3r9cA-4h18A:
undetectable		 3r9cA-4h18A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h63 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 22

(Schizosaccharomyces
pombe) 		PF06179
(Med22)
PF10156
(Med17) 		5 LEU Q 473
LEU V 107
THR Q 388
ASN Q 390
LEU Q 389
 None
 0.79A 3r9cA-4h63Q:
undetectable		 3r9cA-4h63Q:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrt HEMOGLOBIN B CHAIN

(Scapharca
inaequivalvis) 		PF00042
(Globin) 		5 LEU B  36
LEU B  68
ALA B  40
ASN B  41
LEU B  42
 None
 0.91A 3r9cA-4hrtB:
undetectable		 3r9cA-4hrtB:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
oryzae) 		PF01156
(IU_nuc_hydro) 		5 ALA A 452
LEU A 454
LEU A 334
ALA A 450
LEU A 395
 None
 1.15A 3r9cA-4kl0A:
undetectable		 3r9cA-4kl0A:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		5 LEU A 176
LEU A 149
VAL A 151
THR A 169
LEU A 170
 LEU  A 176 ( 0.6A)
LEU  A 149 ( 0.6A)
VAL  A 151 ( 0.6A)
THR  A 169 ( 0.8A)
LEU  A 170 ( 0.5A)
 0.76A 3r9cA-4kqnA:
undetectable		 3r9cA-4kqnA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opw UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF10988
(DUF2807) 		5 ALA A 207
ALA A 188
THR A 168
ASN A 187
LEU A 130
 EDO  A 302 (-3.3A)
None
None
None
None
 1.13A 3r9cA-4opwA:
undetectable		 3r9cA-4opwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PRO A 695
ALA A 477
THR A 478
LEU A 481
LEU A 513
 None
 1.14A 3r9cA-4oqjA:
undetectable		 3r9cA-4oqjA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5b THYMIDYLATE SYNTHASE
THYX

(Streptomyces
cacaoi) 		PF02511
(Thy1) 		5 LEU A 190
LEU A 186
VAL A  74
ALA A 213
LEU A 177
 None
 1.05A 3r9cA-4p5bA:
undetectable		 3r9cA-4p5bA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8s RETICULON-4
RECEPTOR-LIKE 2

(Rattus
norvegicus) 		PF13855
(LRR_8) 		5 ALA A 176
LEU A 174
LEU A 146
LEU A 154
LEU A 111
 None
 1.15A 3r9cA-4p8sA:
undetectable		 3r9cA-4p8sA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II

(Yersinia pestis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 LEU A 299
ALA A 420
THR A 419
LEU A 418
LEU A 354
 None
 1.15A 3r9cA-4pv4A:
undetectable		 3r9cA-4pv4A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8f VACUOLAR
AMINOPEPTIDASE 1

(Saccharomyces
cerevisiae) 		PF02127
(Peptidase_M18) 		5 ALA A 270
LEU A  33
VAL A 313
THR A 288
LEU A 309
 None
 1.13A 3r9cA-4r8fA:
undetectable		 3r9cA-4r8fA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Neisseria
meningitidis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A   4
VAL A 110
ALA A 124
THR A 123
ASN A 125
 None
 1.18A 3r9cA-4rybA:
undetectable		 3r9cA-4rybA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unf ENDONUCLEASE III-1

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		5 ALA A 117
LEU A 124
LEU A  53
THR A 111
LEU A 112
 None
 0.68A 3r9cA-4unfA:
undetectable		 3r9cA-4unfA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2i ESTERASE/LIPASE

(Thalassospira
sp. GB04J01) 		PF07859
(Abhydrolase_3) 		5 PRO A  78
LEU A 314
ALA A 109
LEU A 111
LEU A  99
 None
 1.17A 3r9cA-4v2iA:
undetectable		 3r9cA-4v2iA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaj MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR
RECEPTOR SUBFAMILY 2
GROUP E MEMBER 1

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		5 ALA A1286
LEU A1288
LEU A1347
LEU A1350
LEU A1225
 None
 1.19A 3r9cA-4xajA:
undetectable		 3r9cA-4xajA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaj MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR
RECEPTOR SUBFAMILY 2
GROUP E MEMBER 1

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		5 LEU A1278
LEU A1280
LEU A1288
VAL A1292
LEU A1225
 None
 0.82A 3r9cA-4xajA:
undetectable		 3r9cA-4xajA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7p ALKALINE D-PEPTIDASE

(Bacillus cereus) 		PF00144
(Beta-lactamase) 		5 LEU A  85
LEU A 272
LEU A 266
ALA A  81
THR A  78
 None
 0.98A 3r9cA-4y7pA:
undetectable		 3r9cA-4y7pA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yla AROMATIC
PRENYLTRANSFERASE

(Marinactinospora
thermotolerans) 		PF11991
(Trp_DMAT) 		5 LEU A 197
LEU A 224
LEU A 176
ALA A 193
LEU A 190
 None
 0.98A 3r9cA-4ylaA:
undetectable		 3r9cA-4ylaA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjh ALPHA-2-MACROGLOBULI
N

(Escherichia
coli) 		PF11974
(MG1) 		5 PRO A 283
ALA A 221
LEU A 269
LEU A 229
ASN A 222
 None
 1.01A 3r9cA-4zjhA:
undetectable		 3r9cA-4zjhA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnc HEME BINDING PROTEIN
MSMEG_6519

(Mycolicibacterium
smegmatis) 		PF10615
(DUF2470)
PF13883
(Pyrid_oxidase_2) 		5 ALA A 244
ALA A 255
THR A 256
LEU A 259
LEU A 199
 None
 1.02A 3r9cA-5bncA:
undetectable		 3r9cA-5bncA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
aeruginosa) 		PF00275
(EPSP_synthase) 		5 SER A 315
LEU A 384
LEU A  12
VAL A 252
LEU A 285
 None
 1.17A 3r9cA-5bq2A:
undetectable		 3r9cA-5bq2A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d66 UNCHARACTERIZED
PROTEIN

(Acinetobacter
baumannii) 		PF12796
(Ank_2) 		5 ALA A 116
LEU A 127
LEU A 133
ALA A 143
LEU A 144
 None
 1.19A 3r9cA-5d66A:
undetectable		 3r9cA-5d66A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B

(Homo sapiens) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		5 LEU A 214
LEU A 187
THR A 254
ASN A 256
LEU A 257
 None
 0.90A 3r9cA-5dseA:
undetectable		 3r9cA-5dseA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl3 PILI RETRACTION
PROTEIN PILT

(Thermus
thermophilus) 		PF00437
(T2SSE) 		5 LEU A 266
LEU A 270
LEU A 137
THR A 246
ASN A 248
 None
 1.17A 3r9cA-5fl3A:
undetectable		 3r9cA-5fl3A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmk PRE-MRNA-SPLICING
FACTOR CWC22

(Saccharomyces
cerevisiae) 		PF02847
(MA3) 		5 LEU Z  37
VAL Z  60
ALA Z  81
ASN Z  84
LEU Z  83
 None
 1.13A 3r9cA-5gmkZ:
undetectable		 3r9cA-5gmkZ:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 ALA A  35
LEU A  37
LEU A  67
ALA A  32
LEU A  30
 None
 1.17A 3r9cA-5i2hA:
undetectable		 3r9cA-5i2hA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6b ALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		5 LEU A 365
LEU A 305
LEU A 273
VAL A 436
ALA A 385
 None
 1.02A 3r9cA-5j6bA:
undetectable		 3r9cA-5j6bA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 LEU A 365
LEU A 305
LEU A 273
VAL A 436
ALA A 385
 None
 1.08A 3r9cA-5jryA:
undetectable		 3r9cA-5jryA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m30 TYPE VI SECRETION
PROTEIN

(Escherichia
coli) 		PF05936
(T6SS_VasE) 		5 LEU A 275
LEU A 310
LEU A 208
LEU A 268
LEU A 254
 None
 1.11A 3r9cA-5m30A:
undetectable		 3r9cA-5m30A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfb YIII(DQ)4CQI

(synthetic
construct) 		PF00514
(Arm) 		5 SER A 140
ALA A 120
LEU A 146
LEU A 184
ASN A 163
 None
 1.08A 3r9cA-5mfbA:
undetectable		 3r9cA-5mfbA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfb YIII(DQ)4CQI

(synthetic
construct) 		PF00514
(Arm) 		5 SER A 182
ALA A 162
LEU A 188
LEU A 226
ASN A 205
 None
 1.06A 3r9cA-5mfbA:
undetectable		 3r9cA-5mfbA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 5 LEU A 830
LEU A 630
ALA A 606
ASN A 617
LEU A 783
 None
 1.20A 3r9cA-5ng6A:
undetectable		 3r9cA-5ng6A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 ALA A  75
ALA A 434
THR A 435
ASN A  73
LEU A  72
 None
 0.98A 3r9cA-5ngkA:
undetectable		 3r9cA-5ngkA:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ofq CYTOCHROME P450

(Bacillus
megaterium) 		PF00067
(p450) 		5 SER A  72
LEU A  94
VAL A  98
LEU A 237
LEU A 352
 None
None
None
HEM  A 501 (-4.5A)
HEM  A 501 ( 4.3A)
 0.90A 3r9cA-5ofqA:
42.8		 3r9cA-5ofqA:
34.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35

(Homo sapiens) 		no annotation 5 LEU A 835
LEU A 804
LEU A 596
ASN A 766
LEU A 809
 None
 0.86A 3r9cA-5txkA:
undetectable		 3r9cA-5txkA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb6 UNCHARACTERIZED
PROTEIN YCJY

(Escherichia
coli) 		no annotation 5 LEU A 262
ALA A 124
THR A 123
ASN A 125
LEU A  39
 None
 1.19A 3r9cA-5xb6A:
undetectable		 3r9cA-5xb6A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb6 UNCHARACTERIZED
PROTEIN YCJY

(Escherichia
coli) 		no annotation 5 SER A 255
LEU A 262
ALA A 124
THR A 123
ASN A 125
 None
 0.96A 3r9cA-5xb6A:
undetectable		 3r9cA-5xb6A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		5 LEU A 272
LEU A 283
VAL A 359
ALA A 231
ASN A 230
 None
 1.11A 3r9cA-5xfaA:
undetectable		 3r9cA-5xfaA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog RNA POLYMERASE II
SUBUNIT B32

(Komagataella
phaffii) 		PF03874
(RNA_pol_Rpb4) 		5 LEU D  89
LEU D  64
ASN D 110
LEU D 109
LEU D  51
 None
 1.11A 3r9cA-5xogD:
undetectable		 3r9cA-5xogD:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Homo sapiens) 		no annotation 5 LEU i 179
LEU i 248
ALA i 215
LEU i 211
LEU i 257
 None
 1.01A 3r9cA-5xtci:
1.2		 3r9cA-5xtci:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bld CYTOCHROME P450
268A2 CYP268A2

(Mycobacterium
marinum) 		no annotation 5 SER A  82
ALA A  98
LEU A 113
LEU A 256
LEU A 373
 None
None
None
HEM  A 501 ( 4.8A)
HEM  A 501 (-4.1A)
 0.94A 3r9cA-6bldA:
39.3		 3r9cA-6bldA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blj SERINE-TRNA LIGASE

(Naegleria
fowleri) 		no annotation 5 SER A  60
ALA A 102
LEU A 104
LEU A 112
LEU A  96
 None
 0.92A 3r9cA-6bljA:
undetectable		 3r9cA-6bljA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbl NEAMINE TRANSAMINASE
NEON

(Streptomyces
fradiae) 		no annotation 5 ALA A 271
LEU A 273
LEU A  89
ALA A 269
LEU A 266
 None
 0.83A 3r9cA-6cblA:
undetectable		 3r9cA-6cblA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
putida) 		no annotation 5 SER A 315
LEU A 384
LEU A  12
VAL A 252
LEU A 285
 None
 1.12A 3r9cA-6cn1A:
undetectable		 3r9cA-6cn1A:
11.03