SIMILAR PATTERNS OF AMINO ACIDS FOR 3R9C_A_ECLA451

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbt FOOT-AND-MOUTH
DISEASE VIRUS
(SUBUNIT VP1)


(Foot-and-mouth
disease virus)
PF00073
(Rhv)
5 ALA 1 121
LEU 1 126
LEU 1  53
ALA 1 183
VAL 1  62
None
1.19A 3r9cA-1bbt1:
undetectable
3r9cA-1bbt1:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh6 SUBTILISIN DY

(Bacillus
licheniformis)
PF00082
(Peptidase_S8)
5 ALA A 176
LEU A 250
ALA A 231
VAL A  84
THR A  71
NA  A 502 ( 4.1A)
None
None
None
None
1.26A 3r9cA-1bh6A:
undetectable
3r9cA-1bh6A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis)
PF00082
(Peptidase_S8)
5 ALA A 176
LEU A 250
ALA A 231
VAL A  84
THR A  71
CA  A 284 ( 4.3A)
None
None
None
None
1.20A 3r9cA-1c3lA:
undetectable
3r9cA-1c3lA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj0 PSEUDOURIDINE
SYNTHASE I


(Escherichia
coli)
PF01416
(PseudoU_synth_1)
5 ALA A 237
LEU A 227
ILE A 224
ALA A 152
VAL A 178
None
0.87A 3r9cA-1dj0A:
0.0
3r9cA-1dj0A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekq HYDROXYETHYLTHIAZOLE
KINASE


(Bacillus
subtilis)
PF02110
(HK)
5 ALA A  80
LEU A 117
ILE A 111
ALA A 108
THR A 130
None
1.23A 3r9cA-1ekqA:
undetectable
3r9cA-1ekqA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gll GLYCEROL KINASE

(Escherichia
coli)
no annotation 5 ALA Y 412
LEU Y 418
ALA Y 379
THR Y 339
VAL Y 336
ACP  Y 601 (-3.9A)
None
None
None
None
1.21A 3r9cA-1gllY:
undetectable
3r9cA-1gllY:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvh FLAVOHEMOPROTEIN

(Escherichia
coli)
PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 LEU A 189
LEU A 172
ILE A 219
ALA A 220
VAL A 239
None
1.45A 3r9cA-1gvhA:
0.0
3r9cA-1gvhA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa)
PF00135
(COesterase)
5 ALA A 470
ILE A 238
ALA A 237
THR A 215
VAL A 152
None
1.18A 3r9cA-1gz7A:
undetectable
3r9cA-1gz7A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9l STATIONARY PHASE
SURVIVAL PROTEIN


(Thermotoga
maritima)
PF01975
(SurE)
5 LEU A  19
ILE A 126
ALA A 125
THR A 109
VAL A  31
None
None
None
VO4  A 401 (-3.4A)
None
1.43A 3r9cA-1j9lA:
undetectable
3r9cA-1j9lA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 127
LEU A  39
ILE A 310
ALA A 307
THR A  48
NDP  A1325 ( 4.0A)
None
NDP  A1325 (-4.3A)
None
None
1.43A 3r9cA-1o8cA:
undetectable
3r9cA-1o8cA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1d APYRASE

(Homo sapiens)
PF06079
(Apyrase)
5 ALA A 306
LEU A  64
ILE A  37
ALA A  38
VAL A 102
None
1.34A 3r9cA-1s1dA:
undetectable
3r9cA-1s1dA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1scj SUBTILISIN E

(Bacillus
subtilis)
PF00082
(Peptidase_S8)
5 ALA A 176
LEU A 250
ALA A 231
VAL A  84
THR A  71
CA  A 382 (-3.8A)
None
None
None
None
1.31A 3r9cA-1scjA:
undetectable
3r9cA-1scjA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sv6 2-KETO-4-PENTENOATE
HYDRATASE


(Escherichia
coli)
PF01557
(FAA_hydrolase)
5 ALA A 109
LEU A 205
LEU A 112
ILE A 130
ALA A 129
None
1.19A 3r9cA-1sv6A:
undetectable
3r9cA-1sv6A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE


(Thermotoga
maritima)
PF01207
(Dus)
5 ALA A 106
LEU A  89
ILE A 117
VAL A 154
VAL A 157
None
1.31A 3r9cA-1vhnA:
undetectable
3r9cA-1vhnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xio ANABAENA SENSORY
RHODOPSIN


(Nostoc sp. PCC
7120)
PF01036
(Bac_rhodopsin)
5 ALA A  91
LEU A  87
LEU A 105
ILE A 146
THR A 108
None
None
None
None
PEE  A 309 ( 4.6A)
1.32A 3r9cA-1xioA:
undetectable
3r9cA-1xioA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysy REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)


(Severe acute
respiratory
syndrome-related
coronavirus)
PF08716
(nsp7)
5 LEU A  37
LEU A  42
ILE A  41
ALA A  50
VAL A  18
None
1.05A 3r9cA-1ysyA:
undetectable
3r9cA-1ysyA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbe COAT PROTEIN VP1

(Foot-and-mouth
disease virus)
PF00073
(Rhv)
5 ALA 1 121
LEU 1 126
LEU 1  53
ALA 1 181
VAL 1  62
None
1.12A 3r9cA-1zbe1:
undetectable
3r9cA-1zbe1:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2d N-ACETYLGALACTOSAMIN
E KINASE


(Homo sapiens)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg)
5 ALA A 149
LEU A  68
ILE A  69
ALA A  70
THR A 160
None
0.98A 3r9cA-2a2dA:
undetectable
3r9cA-2a2dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4k 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE


(Thermus
thermophilus)
PF13561
(adh_short_C2)
5 LEU A  75
LEU A 126
THR A   8
VAL A  34
VAL A  70
None
1.27A 3r9cA-2a4kA:
undetectable
3r9cA-2a4kA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axo HYPOTHETICAL PROTEIN
ATU2684


(Agrobacterium
fabrum)
PF06764
(DUF1223)
5 ALA A 249
LEU A 108
LEU A 120
ILE A 119
ALA A 118
None
1.03A 3r9cA-2axoA:
undetectable
3r9cA-2axoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0n A197

(Sulfolobus
turreted
icosahedral
virus 1)
no annotation 5 ALA A  44
LEU A 118
ILE A 123
THR A 162
VAL A 152
None
None
None
None
DIO  A1201 (-4.0A)
1.30A 3r9cA-2c0nA:
undetectable
3r9cA-2c0nA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE


(Bacillus
megaterium)
PF00590
(TP_methylase)
5 LEU A 173
LEU A 155
ILE A 180
ALA A 181
THR A 150
None
1.37A 3r9cA-2cbfA:
undetectable
3r9cA-2cbfA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA


(Escherichia
coli)
PF03054
(tRNA_Me_trans)
5 LEU A 364
ILE A 288
ALA A 289
VAL A 340
VAL A 337
None
0.88A 3r9cA-2detA:
undetectable
3r9cA-2detA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus)
PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C)
5 ALA A 339
ILE A 303
ALA A 302
THR A 277
VAL A 275
None
1.25A 3r9cA-2e28A:
undetectable
3r9cA-2e28A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Sulfurisphaera
tokodaii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 193
LEU A 308
ILE A 305
THR A 153
VAL A 318
None
1.43A 3r9cA-2eerA:
undetectable
3r9cA-2eerA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es9 PUTATIVE CYTOPLASMIC
PROTEIN


(Salmonella
enterica)
PF08986
(DUF1889)
5 ALA A  12
LEU A  45
ILE A  41
ALA A  38
VAL A  58
None
1.44A 3r9cA-2es9A:
undetectable
3r9cA-2es9A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL


(Escherichia
coli)
PF03466
(LysR_substrate)
5 LEU A 242
LEU A 186
ILE A 189
ALA A 190
THR A 196
None
0.82A 3r9cA-2fyiA:
undetectable
3r9cA-2fyiA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gx8 NIF3-RELATED PROTEIN

(Bacillus cereus)
PF01784
(NIF3)
5 LEU A  71
LEU A  31
ILE A  99
ALA A  98
VAL A  43
None
1.43A 3r9cA-2gx8A:
undetectable
3r9cA-2gx8A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE


(Methanocaldococcus
jannaschii)
PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7)
5 ALA A 427
LEU A 463
ILE A 312
ALA A 311
THR A 245
None
1.45A 3r9cA-2hmfA:
2.2
3r9cA-2hmfA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg2 SERINE
PALMITOYLTRANSFERASE


(Sphingomonas
paucimobilis)
PF00155
(Aminotran_1_2)
5 ALA A  60
LEU A 368
ILE A  49
ALA A  48
VAL A  43
None
1.35A 3r9cA-2jg2A:
undetectable
3r9cA-2jg2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1


(Saccharomyces
cerevisiae)
PF00393
(6PGD)
PF03446
(NAD_binding_2)
5 ALA A 177
LEU A 352
ILE A 357
ALA A 358
THR A 376
None
1.26A 3r9cA-2p4qA:
undetectable
3r9cA-2p4qA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)


(Homo sapiens)
PF00215
(OMPdecase)
5 ALA A 258
LEU A 280
ILE A 309
ALA A 337
VAL A 239
None
1.28A 3r9cA-2qcmA:
undetectable
3r9cA-2qcmA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzr POLYPROTEIN

(Foot-and-mouth
disease virus)
PF00073
(Rhv)
5 ALA 1 122
LEU 1 127
LEU 1  54
ALA 1 189
VAL 1  63
None
1.15A 3r9cA-2wzr1:
undetectable
3r9cA-2wzr1:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1i 4-ALPHA-GLUCANOTRANS
FERASE


(Thermus
brockianus)
PF02446
(Glyco_hydro_77)
5 ALA A 283
LEU A 289
ILE A 337
ALA A 339
VAL A 388
None
1.43A 3r9cA-2x1iA:
undetectable
3r9cA-2x1iA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xj9 MIPZ

(Caulobacter
vibrioides)
PF09140
(MipZ)
5 ILE A 234
ALA A 235
THR A  27
VAL A  23
THR A  20
None
None
None
None
AGS  A1272 (-3.7A)
1.31A 3r9cA-2xj9A:
undetectable
3r9cA-2xj9A:
24.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xkr PUTATIVE CYTOCHROME
P450 142


(Mycobacterium
tuberculosis)
PF00067
(p450)
5 LEU A 159
LEU A 163
LEU A 226
ILE A 229
THR A 234
None
PG4  A1399 (-4.8A)
HEM  A1400 (-4.4A)
PG4  A1399 ( 4.5A)
HEM  A1400 (-3.7A)
0.66A 3r9cA-2xkrA:
42.5
3r9cA-2xkrA:
31.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xkr PUTATIVE CYTOCHROME
P450 142


(Mycobacterium
tuberculosis)
PF00067
(p450)
5 LEU A 159
LEU A 226
ILE A 229
THR A 234
VAL A 277
None
HEM  A1400 (-4.4A)
PG4  A1399 ( 4.5A)
HEM  A1400 (-3.7A)
HEM  A1400 (-4.5A)
0.67A 3r9cA-2xkrA:
42.5
3r9cA-2xkrA:
31.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens)
PF03810
(IBN_N)
PF08389
(Xpo1)
5 ALA B 312
LEU B 336
LEU B 323
LEU B 282
ILE B 283
None
1.04A 3r9cA-2xwuB:
undetectable
3r9cA-2xwuB:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus)
PF00067
(p450)
5 LEU A 180
LEU A 240
ILE A 243
ALA A 244
THR A 248
VDX  A 501 (-4.2A)
HEM  A 413 ( 4.5A)
VDX  A 501 (-4.2A)
HEM  A 413 (-3.5A)
HEM  A 413 (-3.2A)
0.67A 3r9cA-2zbzA:
41.9
3r9cA-2zbzA:
35.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]


(Corynebacterium
glutamicum)
PF00821
(PEPCK_C)
PF17297
(PEPCK_N)
5 ALA A 445
LEU A 498
ALA A 567
THR A 538
THR A 431
None
1.46A 3r9cA-2zciA:
undetectable
3r9cA-2zciA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE


(Escherichia
coli)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
5 ALA A 203
LEU A 181
ALA A 155
VAL A 167
VAL A 176
None
1.42A 3r9cA-3a8kA:
undetectable
3r9cA-3a8kA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE


(Thermococcus
kodakarensis)
PF00082
(Peptidase_S8)
PF04151
(PPC)
5 ALA A 206
LEU A 208
ILE A 145
VAL A 229
VAL A 233
None
1.44A 3r9cA-3afgA:
undetectable
3r9cA-3afgA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE


(Mycobacterium
tuberculosis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 ALA A  83
LEU A  49
ALA A 426
VAL A 242
THR A 216
None
1.30A 3r9cA-3ce6A:
undetectable
3r9cA-3ce6A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnh HYDROLASE FAMILY
PROTEIN


(Deinococcus
radiodurans)
PF13419
(HAD_2)
5 ALA A 144
LEU A 106
LEU A 150
ALA A 153
VAL A 163
None
1.02A 3r9cA-3cnhA:
undetectable
3r9cA-3cnhA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq0 PUTATIVE
TRANSALDOLASE
YGR043C


(Saccharomyces
cerevisiae)
PF00923
(TAL_FSA)
5 LEU A 171
ALA A 181
THR A 232
VAL A 234
VAL A 218
None
1.14A 3r9cA-3cq0A:
undetectable
3r9cA-3cq0A:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME


(Bacillus
subtilis)
PF00067
(p450)
5 LEU B 164
LEU B 230
ILE B 233
ALA B 234
THR B 238
None
HEM  B 405 ( 4.6A)
None
HEM  B 405 (-3.5A)
HEM  B 405 (-3.7A)
0.53A 3r9cA-3ejbB:
46.6
3r9cA-3ejbB:
34.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftt PUTATIVE
ACETYLTRANSFERASE
SACOL2570


(Staphylococcus
aureus)
PF00132
(Hexapep)
PF12464
(Mac)
PF14602
(Hexapep_2)
5 LEU A  49
ILE A  31
ALA A  28
THR A  69
VAL A  75
None
1.41A 3r9cA-3fttA:
undetectable
3r9cA-3fttA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ILE A 175
ALA A 182
THR A 105
VAL A 107
VAL A 109
None
1.26A 3r9cA-3hhdA:
undetectable
3r9cA-3hhdA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyv SULFIDE-QUINONE
REDUCTASE


(Aquifex
aeolicus)
PF07992
(Pyr_redox_2)
5 LEU A  32
ILE A  15
ALA A  16
VAL A 102
VAL A   5
None
1.09A 3r9cA-3hyvA:
undetectable
3r9cA-3hyvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isp HTH-TYPE
TRANSCRIPTIONAL
REGULATOR
RV1985C/MT2039


(Mycobacterium
tuberculosis)
PF00126
(HTH_1)
PF03466
(LysR_substrate)
5 ALA A  64
LEU A  44
LEU A  69
ALA A  72
VAL A  37
None
1.07A 3r9cA-3ispA:
undetectable
3r9cA-3ispA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE


(Staphylococcus
aureus)
PF01791
(DeoC)
5 ALA A  90
LEU A  68
LEU A  87
ALA A  57
THR A  61
None
1.28A 3r9cA-3kaoA:
undetectable
3r9cA-3kaoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3s ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN


(Ruegeria
pomeroyi)
PF00378
(ECH_1)
5 ALA A  42
LEU A  21
LEU A  23
ILE A  57
ALA A 110
None
1.43A 3r9cA-3l3sA:
undetectable
3r9cA-3l3sA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mve UPF0255 PROTEIN
VV1_0328


(Vibrio
vulnificus)
PF06500
(DUF1100)
5 ALA A 291
LEU A 409
LEU A 414
ILE A 222
ALA A 223
None
1.40A 3r9cA-3mveA:
undetectable
3r9cA-3mveA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwy URIDYLATE KINASE

(Mycobacterium
tuberculosis)
PF00696
(AA_kinase)
5 ALA A 184
LEU A  35
THR A 122
VAL A 124
VAL A 105
None
1.24A 3r9cA-3nwyA:
undetectable
3r9cA-3nwyA:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r9b CYTOCHROME P450
164A2


(Mycolicibacterium
smegmatis)
PF00067
(p450)
5 ALA A  95
ALA A 256
THR A 260
VAL A 303
THR A 403
None
HEM  A 501 ( 3.5A)
HEM  A 501 (-3.4A)
HEM  A 501 (-4.7A)
D12  A 509 ( 4.6A)
1.06A 3r9cA-3r9bA:
62.5
3r9cA-3r9bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r9b CYTOCHROME P450
164A2


(Mycolicibacterium
smegmatis)
PF00067
(p450)
9 LEU A 180
LEU A 184
LEU A 252
ILE A 255
ALA A 256
THR A 260
VAL A 303
VAL A 306
THR A 403
None
D12  A 509 ( 4.3A)
HEM  A 501 ( 4.5A)
D12  A 509 ( 4.1A)
HEM  A 501 ( 3.5A)
HEM  A 501 (-3.4A)
HEM  A 501 (-4.7A)
D12  A 509 ( 4.5A)
D12  A 509 ( 4.6A)
0.52A 3r9cA-3r9bA:
62.5
3r9cA-3r9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3so4 METHIONINE-ADENOSYLT
RANSFERASE


(Entamoeba
histolytica)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
5 LEU A 332
LEU A 382
ALA A 295
VAL A 301
THR A 321
None
1.45A 3r9cA-3so4A:
undetectable
3r9cA-3so4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 ALA A 120
LEU A 113
ILE A 164
ALA A 161
THR A 136
None
1.36A 3r9cA-3sqwA:
undetectable
3r9cA-3sqwA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t58 SULFHYDRYL OXIDASE 1

(Mus musculus)
PF00085
(Thioredoxin)
PF04777
(Evr1_Alr)
5 ALA A 156
LEU A  97
LEU A 208
ALA A 167
VAL A 218
None
1.42A 3r9cA-3t58A:
undetectable
3r9cA-3t58A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf6 LMO1369 PROTEIN

(Listeria
monocytogenes)
PF01515
(PTA_PTB)
5 ALA A 226
LEU A 229
ILE A 131
ALA A 118
VAL A 245
None
1.38A 3r9cA-3uf6A:
undetectable
3r9cA-3uf6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vk5 MOEO5

(Streptomyces
viridosporus)
PF01884
(PcrB)
5 ALA A 112
LEU A 115
LEU A 153
LEU A  66
VAL A 224
None
1.34A 3r9cA-3vk5A:
undetectable
3r9cA-3vk5A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA


(Bos taurus)
PF00118
(Cpn60_TCP1)
5 LEU A  58
LEU A  25
ILE A  22
ALA A  21
VAL A  63
None
1.23A 3r9cA-4a0wA:
undetectable
3r9cA-4a0wA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN


(Escherichia
coli)
PF00448
(SRP54)
PF02881
(SRP54_N)
5 LEU A 240
ALA A 106
THR A 191
VAL A 189
VAL A 102
None
1.41A 3r9cA-4c7oA:
undetectable
3r9cA-4c7oA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima)
PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim)
5 LEU A 829
ILE A 825
ALA A 821
VAL A1008
VAL A1026
None
1.16A 3r9cA-4ddwA:
undetectable
3r9cA-4ddwA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Thermobispora
bispora)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ALA A  81
LEU A  65
ALA A 111
VAL A  36
VAL A  70
None
1.40A 3r9cA-4dhgA:
undetectable
3r9cA-4dhgA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN


(Methanosarcina
mazei)
PF01458
(UPF0051)
5 ALA A 302
LEU A 289
ALA A 278
VAL A 222
THR A 220
None
1.09A 3r9cA-4dn7A:
2.4
3r9cA-4dn7A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ess OR187

(synthetic
construct)
PF01661
(Macro)
5 ALA A 152
ALA A 115
VAL A  89
VAL A 128
THR A  93
None
1.31A 3r9cA-4essA:
undetectable
3r9cA-4essA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13


(Candida
albicans)
PF09084
(NMT1)
5 ALA A 223
LEU A  35
ILE A  37
ALA A  38
VAL A  57
None
1.42A 3r9cA-4eswA:
undetectable
3r9cA-4eswA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP1

(Foot-and-mouth
disease virus)
PF00073
(Rhv)
5 ALA A 121
LEU A 126
LEU A  53
ALA A 182
VAL A  62
None
1.16A 3r9cA-4gh4A:
undetectable
3r9cA-4gh4A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijn ACETATE KINASE

(Mycolicibacterium
smegmatis)
PF00871
(Acetate_kinase)
5 ALA A 198
LEU A 188
ILE A 293
VAL A 319
VAL A 312
None
None
None
None
AMP  A 402 (-4.1A)
1.34A 3r9cA-4ijnA:
undetectable
3r9cA-4ijnA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0c DEFORMYLASE

(Pseudomonas
putida)
PF12697
(Abhydrolase_6)
5 ALA A 104
LEU A 114
ILE A 202
THR A 230
VAL A 206
None
1.22A 3r9cA-4l0cA:
undetectable
3r9cA-4l0cA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Gallus gallus)
PF07714
(Pkinase_Tyr)
5 LEU A 387
ILE A 370
ALA A 371
VAL A 377
VAL A 383
None
1.42A 3r9cA-4lggA:
undetectable
3r9cA-4lggA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE


(Sphaerobacter
thermophilus)
no annotation 5 ALA B 278
LEU B 363
LEU B 136
ILE B 133
ALA B 132
None
1.15A 3r9cA-4ritB:
undetectable
3r9cA-4ritB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tl3 ANABAENA SENSORY
RHODOPSIN


(Nostoc sp. PCC
7120)
PF01036
(Bac_rhodopsin)
5 ALA A  91
LEU A  87
LEU A 105
ILE A 146
THR A 108
None
None
None
None
PEE  A 319 ( 4.4A)
1.32A 3r9cA-4tl3A:
undetectable
3r9cA-4tl3A:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ubs PENTALENIC ACID
SYNTHASE


(Streptomyces
avermitilis)
PF00067
(p450)
5 LEU A 178
LEU A 237
ALA A 241
THR A 245
THR A 391
None
DIF  A 502 (-4.4A)
HEM  A 501 ( 3.8A)
HEM  A 501 ( 3.3A)
None
1.21A 3r9cA-4ubsA:
42.5
3r9cA-4ubsA:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ubs PENTALENIC ACID
SYNTHASE


(Streptomyces
avermitilis)
PF00067
(p450)
5 LEU A 237
ILE A 240
ALA A 241
THR A 245
THR A 391
DIF  A 502 (-4.4A)
DIF  A 502 (-3.3A)
HEM  A 501 ( 3.8A)
HEM  A 501 ( 3.3A)
None
1.01A 3r9cA-4ubsA:
42.5
3r9cA-4ubsA:
32.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woe TAUROCYAMINE KINASE

(Schistosoma
mansoni)
PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN)
5 LEU A 372
ILE A 413
ALA A 410
THR A 408
THR A 498
None
1.28A 3r9cA-4woeA:
undetectable
3r9cA-4woeA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
5 ALA A 645
LEU A 611
ILE A 628
ALA A 627
VAL A 620
GOL  A 915 ( 4.5A)
GOL  A 911 ( 4.1A)
None
None
None
1.33A 3r9cA-4xriA:
2.8
3r9cA-4xriA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Yersinia pestis)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 ALA A 254
LEU A 299
LEU A 219
ALA A 302
THR A 116
None
None
None
SCY  A 112 ( 3.7A)
None
1.15A 3r9cA-4z19A:
undetectable
3r9cA-4z19A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aca VP1

(Foot-and-mouth
disease virus)
PF00073
(Rhv)
5 ALA 1 121
LEU 1 126
LEU 1  53
ALA 1 188
VAL 1  62
None
1.22A 3r9cA-5aca1:
undetectable
3r9cA-5aca1:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej2 CARVEOL
DEHYDROGENASE


(Mycobacterium
avium)
PF13561
(adh_short_C2)
5 ALA A 110
ILE A  45
ALA A  81
VAL A  71
THR A  67
None
1.36A 3r9cA-5ej2A:
undetectable
3r9cA-5ej2A:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
5 LEU A 232
ILE A 235
ALA A 236
THR A 240
VAL A 283
HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
1.14A 3r9cA-5gnmA:
41.7
3r9cA-5gnmA:
39.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE


(Thermococcus
kodakarensis)
PF02449
(Glyco_hydro_42)
5 ALA A 616
LEU A 619
ILE A 597
VAL A 574
VAL A 588
None
None
PPI  A 809 ( 4.2A)
None
None
1.44A 3r9cA-5gsmA:
undetectable
3r9cA-5gsmA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h45 DNA REPAIR PROTEIN
RADA


(Thermus
thermophilus)
PF13541
(ChlI)
5 ALA A 296
LEU A 323
ALA A 354
VAL A 378
VAL A 318
None
1.27A 3r9cA-5h45A:
undetectable
3r9cA-5h45A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 ALA A 131
LEU A 128
ILE A 425
ALA A 426
VAL A 111
None
None
None
PEG  A 707 (-4.5A)
None
1.34A 3r9cA-5i51A:
undetectable
3r9cA-5i51A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0n INTEGRASE

(Escherichia
virus Lambda)
PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1)
5 LEU E 229
LEU E 216
ILE E 271
THR E 258
THR E 244
None
1.26A 3r9cA-5j0nE:
undetectable
3r9cA-5j0nE:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l94 CYTOCHROME P450

(Bacillus
megaterium)
PF00067
(p450)
5 LEU A 238
ILE A 241
ALA A 242
THR A 246
VAL A 289
HEM  A 501 (-4.4A)
TES  A 502 (-4.0A)
HEM  A 501 (-3.5A)
HEM  A 501 (-3.4A)
TES  A 502 (-4.8A)
0.37A 3r9cA-5l94A:
47.4
3r9cA-5l94A:
35.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp5 ROD
SHAPE-DETERMINING
PROTEIN (MREC)


(Helicobacter
pylori)
PF04085
(MreC)
5 LEU C 128
ALA C 156
VAL C 159
VAL C 195
THR C 197
None
1.27A 3r9cA-5lp5C:
undetectable
3r9cA-5lp5C:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1


(Saccharomyces
cerevisiae)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
5 LEU T2263
LEU T2259
ILE T2217
ALA T2216
VAL T2209
None
0.89A 3r9cA-5ojsT:
undetectable
3r9cA-5ojsT:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol1 DNA POLYMERASE III
SUBUNIT ALPHA,DNA
POLYMERASE III
SUBUNIT ALPHA


(Synechocystis
sp. PCC 6803)
no annotation 5 LEU A 139
LEU A  28
ILE A  33
ALA A  34
VAL A   4
None
1.26A 3r9cA-5ol1A:
undetectable
3r9cA-5ol1A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN


(Treponema
pallidum)
PF01547
(SBP_bac_1)
5 ALA A 221
LEU A 217
ILE A 384
ALA A 383
THR A 309
None
None
None
EDO  A 504 (-2.8A)
None
1.40A 3r9cA-5u2pA:
undetectable
3r9cA-5u2pA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE


(Burkholderia
multivorans)
PF00171
(Aldedh)
5 ALA A  96
LEU A 263
ALA A  64
VAL A  69
THR A 265
None
1.42A 3r9cA-5ujuA:
undetectable
3r9cA-5ujuA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCD
MDCE


(Pseudomonas
aeruginosa)
PF01039
(Carboxyl_trans)
PF06833
(MdcE)
5 ALA A 144
LEU A 115
ILE B 165
ALA B 166
VAL B 141
None
0.98A 3r9cA-5vipA:
undetectable
3r9cA-5vipA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE


(unidentified)
PF00465
(Fe-ADH)
5 ALA A 191
LEU A 127
ALA A 122
VAL A 113
VAL A 111
None
1.10A 3r9cA-5xn8A:
undetectable
3r9cA-5xn8A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ynl ARGINASE

(Glaciozyma
antarctica)
no annotation 5 LEU A 280
LEU A 227
LEU A 240
ILE A 238
VAL A 222
None
1.15A 3r9cA-5ynlA:
undetectable
3r9cA-5ynlA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bld CYTOCHROME P450
268A2 CYP268A2


(Mycobacterium
marinum)
no annotation 5 LEU A 187
LEU A 256
ALA A 260
THR A 264
VAL A 308
DXJ  A 502 (-3.6A)
HEM  A 501 ( 4.8A)
HEM  A 501 ( 3.6A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 4.6A)
0.77A 3r9cA-6bldA:
39.3
3r9cA-6bldA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blm 4-OXALOCROTONATE
TAUTOMERASE


(Burkholderia
lata)
no annotation 5 ALA A  94
LEU A  24
ILE A  69
ALA A  71
VAL A  39
None
1.17A 3r9cA-6blmA:
undetectable
3r9cA-6blmA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT D


(Flavobacterium
johnsoniae)
no annotation 5 ALA C 214
LEU D  16
LEU D 144
ILE D 145
ALA D   8
None
1.19A 3r9cA-6btmC:
1.3
3r9cA-6btmC:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE


(Medicago
truncatula)
no annotation 5 LEU A 296
ALA A 291
THR A 314
VAL A 312
VAL A 309
None
LLP  A 318 (-3.3A)
FMT  A 613 ( 4.6A)
None
None
1.45A 3r9cA-6cczA:
undetectable
3r9cA-6cczA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-)
no annotation 5 ALA B  75
LEU B  41
ALA B 392
VAL B 188
THR B 162
None
1.32A 3r9cA-6f3mB:
undetectable
3r9cA-6f3mB:
undetectable