SIMILAR PATTERNS OF AMINO ACIDS FOR 3R75_B_BEZB701_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bkh | MUCONATE LACTONIZINGENZYME (Pseudomonasputida) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 274GLY A 308THR A 309GLU A 50THR A 52 | None | 1.21A | 3r75B-1bkhA:undetectable | 3r75B-1bkhA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i7q | ANTHRANILATESYNTHASE (Serratiamarcescens) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 9 | GLU A 309ILE A 326GLY A 328THR A 329GLU A 361HIS A 398ARG A 469GLU A 498LYS A 502 | BEZ A1501 (-3.8A)BEZ A1501 (-3.9A)BEZ A1501 (-3.3A)BEZ A1501 (-3.9A) MG A1701 ( 3.1A)BEZ A1501 ( 4.2A)PYR A1601 ( 3.9A) MG A1701 ( 2.6A)BEZ A1501 ( 2.9A) | 0.41A | 3r75B-1i7qA:37.1 | 3r75B-1i7qA:24.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i7q | ANTHRANILATESYNTHASE (Serratiamarcescens) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 7 | GLY A 328THR A 329GLU A 358HIS A 398ARG A 469GLU A 498LYS A 502 | BEZ A1501 (-3.3A)BEZ A1501 (-3.9A) MG A1701 ( 4.3A)BEZ A1501 ( 4.2A)PYR A1601 ( 3.9A) MG A1701 ( 2.6A)BEZ A1501 ( 2.9A) | 1.45A | 3r75B-1i7qA:37.1 | 3r75B-1i7qA:24.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ihp | PHYTASE (Aspergillusficuum) |
PF00328(His_Phos_2) | 5 | ILE A 144SER A 140GLY A 139GLU A 179SER A 337 | None | 1.49A | 3r75B-1ihpA:undetectable | 3r75B-1ihpA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhm | S-ADENOSYLMETHIONINEDECARBOXYLASE (Solanumtuberosum) |
PF01536(SAM_decarbox) | 5 | ILE A 329SER A 328GLY A 327HIS A 294THR A 299 | None | 1.23A | 3r75B-1mhmA:2.2 | 3r75B-1mhmA:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qdl | PROTEIN(ANTHRANILATESYNTHASE(TRPE-SUBUNIT)) (Sulfolobussolfataricus) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 5 | GLU A 225ILE A 240GLY A 242THR A 243HIS A 306 | None | 0.38A | 3r75B-1qdlA:40.6 | 3r75B-1qdlA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpe | PHOSPHOGLYCERATEKINASE (Thermotogamaritima) |
PF00162(PGK) | 5 | ILE A 159SER A 155GLU A 123SER A 58THR A 117 | None | 1.49A | 3r75B-1vpeA:2.4 | 3r75B-1vpeA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vra | ARGININEBIOSYNTHESISBIFUNCTIONAL PROTEINARGJARGININEBIOSYNTHESISBIFUNCTIONAL PROTEINARGJ (Bacillushalodurans;Bacillushalodurans) |
PF01960(ArgJ)PF01960(ArgJ) | 5 | GLU B 283GLY A 124THR A 123SER B 235LYS B 197 | EDO B 10 (-2.6A)SO4 A 197 ( 3.3A)SO4 A 197 (-3.9A)NoneSO4 A 197 (-3.8A) | 1.32A | 3r75B-1vraB:undetectable | 3r75B-1vraB:16.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vz8 | ORNITHINEACETYL-TRANSFERASE (Streptomycesclavuligerus) |
PF01960(ArgJ) | 5 | GLU A 260GLY A 112THR A 111SER A 219LYS A 181 | NoneSO4 A1391 (-3.3A)SO4 A1391 (-3.4A)NoneSO4 A1391 (-4.4A) | 1.32A | 3r75B-1vz8A:undetectable | 3r75B-1vz8A:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wlm | PROTEIN CGI-38 (Mus musculus) |
PF05517(p25-alpha) | 5 | GLU A 144SER A 141GLY A 140THR A 139HIS A 142 | None | 1.19A | 3r75B-1wlmA:undetectable | 3r75B-1wlmA:12.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b3x | IRON-RESPONSIVEELEMENT BINDINGPROTEIN 1 (Homo sapiens) |
PF00330(Aconitase)PF00694(Aconitase_C) | 5 | GLU A 225ILE A 235SER A 236GLU A 75THR A 867 | None | 1.37A | 3r75B-2b3xA:undetectable | 3r75B-2b3xA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2crq | MITOCHONDRIALTRANSLATIONALINITIATION FACTOR 3 (Mus musculus) |
PF00707(IF3_C) | 5 | ILE A 87GLY A 90THR A 91GLU A 60THR A 63 | None | 1.49A | 3r75B-2crqA:undetectable | 3r75B-2crqA:9.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d3t | FATTY OXIDATIONCOMPLEX ALPHASUBUNIT (Pseudomonasfragi) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 5 | ILE A 145GLY A 148GLU A 274THR A 152GLU A 120 | None | 0.91A | 3r75B-2d3tA:3.3 | 3r75B-2d3tA:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ghs | AGR_C_1268P (Agrobacteriumfabrum) |
PF08450(SGL) | 5 | ILE A 151SER A 150GLY A 149THR A 139GLU A 116 | None | 1.14A | 3r75B-2ghsA:undetectable | 3r75B-2ghsA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jg7 | ANTIQUITIN (Acanthopagrusschlegelii) |
PF00171(Aldedh) | 5 | SER A 33GLY A 32THR A 52GLU A 58THR A 55 | None | 1.43A | 3r75B-2jg7A:4.3 | 3r75B-2jg7A:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jkd | PRE-MRNA LEAKAGEPROTEIN 1 (Saccharomycescerevisiae) |
PF00498(FHA) | 5 | SER A 189GLY A 164THR A 165SER A 136THR A 135 | None | 1.46A | 3r75B-2jkdA:undetectable | 3r75B-2jkdA:15.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pm9 | PROTEIN TRANSPORTPROTEIN SEC31 (Saccharomycescerevisiae) |
PF00400(WD40) | 5 | ILE A 260SER A 276THR A 281HIS A 256THR A 306 | None | 1.49A | 3r75B-2pm9A:undetectable | 3r75B-2pm9A:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pyy | IONOTROPIC GLUTAMATERECEPTOR BACTERIALHOMOLOGUE (Nostocpunctiforme) |
PF00497(SBP_bac_3) | 5 | GLU A 182SER A 119GLY A 118THR A 115GLU A 134 | NoneGLU A1620 (-4.7A)NoneNoneNone | 1.50A | 3r75B-2pyyA:undetectable | 3r75B-2pyyA:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pyy | IONOTROPIC GLUTAMATERECEPTOR BACTERIALHOMOLOGUE (Nostocpunctiforme) |
PF00497(SBP_bac_3) | 5 | ILE A 69SER A 70GLU A 182SER A 119THR A 120 | GLU A1620 (-4.9A)GLU A1620 (-2.9A)NoneGLU A1620 (-4.7A)GLU A1620 (-3.4A) | 1.41A | 3r75B-2pyyA:undetectable | 3r75B-2pyyA:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qvp | UNCHARACTERIZEDPROTEIN (Shewanellaamazonensis) |
PF04952(AstE_AspA) | 5 | SER A 191GLY A 188GLU A 182HIS A 192THR A 180 | NoneSO4 A 276 (-3.2A)NoneNoneNone | 1.44A | 3r75B-2qvpA:undetectable | 3r75B-2qvpA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qwv | UPF0217 PROTEINVC_A1059 (Vibrio cholerae) |
PF04013(Methyltrn_RNA_2) | 5 | GLU A 104ILE A 118SER A 119GLU A 121GLU A 60 | None | 1.46A | 3r75B-2qwvA:undetectable | 3r75B-2qwvA:18.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2tpt | THYMIDINEPHOSPHORYLASE (Escherichiacoli) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N)PF07831(PYNP_C) | 5 | GLU A 194ILE A 112SER A 113GLY A 114SER A 86 | NoneNoneSO4 A 441 (-2.7A)NoneSO4 A 441 ( 4.4A) | 0.93A | 3r75B-2tptA:undetectable | 3r75B-2tptA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v26 | MYOSIN VI (Sus scrofa) |
PF00063(Myosin_head) | 5 | ILE A 147SER A 146GLY A 453SER A 144THR A 661 | None | 1.15A | 3r75B-2v26A:2.0 | 3r75B-2v26A:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x58 | PEROXISOMALBIFUNCTIONAL ENZYME (Rattusnorvegicus) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 5 | ILE A 128GLY A 131GLU A 251THR A 135GLU A 103 | NoneGOL A 770 (-3.7A)NoneNoneGOL A 770 (-2.9A) | 1.10A | 3r75B-2x58A:undetectable | 3r75B-2x58A:23.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y9e | MYOSIN-2 (Dictyosteliumdiscoideum) |
PF00063(Myosin_head)PF02736(Myosin_N) | 5 | ILE X 455GLY X 457GLU X 459SER X 181LYS X 185 | None | 1.47A | 3r75B-2y9eX:undetectable | 3r75B-2y9eX:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y9e | MYOSIN-2 (Dictyosteliumdiscoideum) |
PF00063(Myosin_head)PF02736(Myosin_N) | 5 | ILE X 455SER X 456GLY X 457GLU X 459GLU X 180 | None | 1.48A | 3r75B-2y9eX:undetectable | 3r75B-2y9eX:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxe | PROTEIN-L-ISOASPARTATEO-METHYLTRANSFERASE (Methanocaldococcusjannaschii) |
PF01135(PCMT) | 5 | ILE A 131SER A 107GLU A 83ARG A 123THR A 86 | None | 1.17A | 3r75B-2yxeA:undetectable | 3r75B-2yxeA:17.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bzm | MENAQUINONE-SPECIFICISOCHORISMATESYNTHASE (Escherichiacoli) |
PF00425(Chorismate_bind) | 7 | GLU A 240GLY A 257THR A 258HIS A 318ARG A 387GLU A 416LYS A 420 | None | 0.65A | 3r75B-3bzmA:38.8 | 3r75B-3bzmA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d46 | PUTATIVE GALACTONATEDEHYDRATASE (Salmonellaenterica) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 137SER A 138GLY A 308THR A 311HIS A 116 | None | 1.38A | 3r75B-3d46A:undetectable | 3r75B-3d46A:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d6c | THERMONUCLEASE (Staphylococcusaureus) |
PF00565(SNase) | 5 | GLU A 57SER A 59GLY A 20THR A 41THR A 44 | NoneNoneNone CA A 150 (-4.9A)None | 1.37A | 3r75B-3d6cA:undetectable | 3r75B-3d6cA:13.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3els | PRE-MRNA LEAKAGEPROTEIN 1 (Saccharomycescerevisiae) |
PF00498(FHA) | 5 | GLU A 192SER A 189GLY A 164THR A 165SER A 136 | None | 1.45A | 3r75B-3elsA:undetectable | 3r75B-3elsA:13.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fcp | L-ALA-D/L-GLUEPIMERASE, AMUCONATE LACTONIZINGENZYME (Klebsiellapneumoniae) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 275GLY A 309THR A 310GLU A 51THR A 53 | None | 1.20A | 3r75B-3fcpA:undetectable | 3r75B-3fcpA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fj4 | MUCONATECYCLOISOMERASE (Pseudomonasprotegens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 276GLY A 310THR A 311GLU A 52THR A 54 | None | 1.19A | 3r75B-3fj4A:undetectable | 3r75B-3fj4A:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gei | TRNA MODIFICATIONGTPASE MNME (Chlorobaculumtepidum) |
PF01926(MMR_HSR1)PF10396(TrmE_N)PF12631(MnmE_helical) | 5 | ILE A 32SER A 33GLY A 34GLU A 91THR A 89 | None | 1.16A | 3r75B-3geiA:undetectable | 3r75B-3geiA:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gkb | PUTATIVE ENOYL-COAHYDRATASE (Streptomycesavermitilis) |
PF00378(ECH_1) | 5 | ILE A 147GLY A 150GLU A 234THR A 154GLU A 121 | None | 0.92A | 3r75B-3gkbA:undetectable | 3r75B-3gkbA:20.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gse | MENAQUINONE-SPECIFICISOCHORISMATESYNTHASE (Yersinia pestis) |
PF00425(Chorismate_bind) | 5 | GLU A 258GLY A 275THR A 276GLU A 302HIS A 336 | None | 0.29A | 3r75B-3gseA:34.4 | 3r75B-3gseA:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdi | PROCESSING PROTEASE (Bacillushalodurans) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 5 | ILE A 398SER A 397GLY A 240SER A 143THR A 146 | None | 1.12A | 3r75B-3hdiA:undetectable | 3r75B-3hdiA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3it4 | ARGININEBIOSYNTHESISBIFUNCTIONAL PROTEINARGJ ALPHA CHAINARGININEBIOSYNTHESISBIFUNCTIONAL PROTEINARGJ BETA CHAIN (Mycobacteriumtuberculosis;Mycobacteriumtuberculosis) |
PF01960(ArgJ)PF01960(ArgJ) | 5 | GLU B 280GLY A 128THR A 127SER B 238LYS B 200 | None | 1.24A | 3r75B-3it4B:undetectable | 3r75B-3it4B:16.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3no8 | BTB/POZDOMAIN-CONTAININGPROTEIN 2 (Homo sapiens) |
PF08005(PHR) | 5 | ILE A 412SER A 411GLY A 410HIS A 477THR A 416 | None | 1.23A | 3r75B-3no8A:undetectable | 3r75B-3no8A:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3os6 | ISOCHORISMATESYNTHASE DHBC (Bacillusanthracis) |
PF00425(Chorismate_bind) | 6 | GLU A 197GLY A 214HIS A 276ARG A 348GLU A 377LYS A 381 | NoneSO4 A 404 (-3.8A)NoneNoneSO4 A 404 (-4.1A)SO4 A 404 (-2.9A) | 0.63A | 3r75B-3os6A:38.6 | 3r75B-3os6A:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ppo | GLYCINEBETAINE/CARNITINE/CHOLINE-BINDINGPROTEIN (Bacillussubtilis) |
PF04069(OpuAC) | 5 | ILE A 199THR A 42GLU A 43ARG A 222THR A 219 | None | 1.30A | 3r75B-3ppoA:undetectable | 3r75B-3ppoA:18.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3r75 | ANTHRANILATE/PARA-AMINOBENZOATESYNTHASES COMPONENTI (Burkholderialata) |
PF00117(GATase)PF00425(Chorismate_bind) | 12 | GLU A 201ILE A 216SER A 217GLY A 218THR A 219GLU A 244HIS A 279ARG A 352SER A 368THR A 369GLU A 382LYS A 386 | BEZ A 701 ( 4.3A)BEZ A 701 (-4.2A)BEZ A 701 (-3.2A)BEZ A 701 (-3.5A)BEZ A 701 (-4.0A) MG A 700 ( 2.5A)BEZ A 701 (-3.8A)PYR A 702 ( 3.9A)NoneBEZ A 701 (-4.1A) MG A 700 ( 2.5A)PYR A 702 ( 3.1A) | 0.05A | 3r75B-3r75A:71.0 | 3r75B-3r75A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3r75 | ANTHRANILATE/PARA-AMINOBENZOATESYNTHASES COMPONENTI (Burkholderialata) |
PF00117(GATase)PF00425(Chorismate_bind) | 5 | GLU A 201THR A 369GLU A 382THR A 219GLU A 244 | BEZ A 701 ( 4.3A)BEZ A 701 (-4.1A) MG A 700 ( 2.5A)BEZ A 701 (-4.0A) MG A 700 ( 2.5A) | 1.10A | 3r75B-3r75A:71.0 | 3r75B-3r75A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rd8 | FUMARATE HYDRATASECLASS II (Mycolicibacteriumsmegmatis) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | ILE A 360SER A 102GLY A 101SER A 105THR A 104 | None | 1.19A | 3r75B-3rd8A:undetectable | 3r75B-3rd8A:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rr2 | CYSTEINE SYNTHASE (Mycobacteriummarinum) |
PF00291(PALP) | 5 | ILE A 11GLY A 13THR A 14GLU A 161THR A 157 | None | 1.32A | 3r75B-3rr2A:3.4 | 3r75B-3rr2A:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rrp | PROBABLE FUMARATEHYDRATASE FUM (Mycobacteroidesabscessus) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | ILE A 361SER A 101GLY A 100SER A 104THR A 103 | NoneLMR A 468 (-2.9A)NoneNoneLMR A 468 (-2.9A) | 1.16A | 3r75B-3rrpA:undetectable | 3r75B-3rrpA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vtr | N-ACETYLGLUCOSAMINIDASE (Ostriniafurnacalis) |
PF00728(Glyco_hydro_20)PF14845(Glycohydro_20b2) | 5 | ILE A 203SER A 204GLY A 71THR A 70SER A 150 | None | 1.39A | 3r75B-3vtrA:undetectable | 3r75B-3vtrA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4anj | UNCONVENTIONALMYOSIN-VI, GREENFLUORESCENT PROTEIN (Aequoreavictoria;Sus scrofa) |
PF00063(Myosin_head)PF01353(GFP) | 5 | ILE A 147SER A 146GLY A 453SER A 144THR A 661 | None | 1.24A | 3r75B-4anjA:undetectable | 3r75B-4anjA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4apb | FUMARATE HYDRATASECLASS II (Mycobacteriumtuberculosis) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | ILE A 362SER A 104GLY A 103SER A 107THR A 106 | None | 1.16A | 3r75B-4apbA:undetectable | 3r75B-4apbA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bin | N-ACETYLMURAMOYL-L-ALANINE AMIDASE AMIC (Escherichiacoli) |
PF01520(Amidase_3)PF11741(AMIN) | 5 | SER A 275GLY A 276GLU A 382HIS A 350SER A 378 | None | 1.45A | 3r75B-4binA:undetectable | 3r75B-4binA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bzk | PROTEIN TRANSPORTPROTEIN SEC31 (Saccharomycescerevisiae) |
PF00400(WD40)PF12931(Sec16_C) | 5 | ILE A 260SER A 276THR A 281HIS A 256THR A 306 | None | 1.49A | 3r75B-4bzkA:undetectable | 3r75B-4bzkA:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cak | INTEGRIN ALPHA-IIBINTEGRIN BETA-3 (Homo sapiens;Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2)PF00362(Integrin_beta)PF07965(Integrin_B_tail)PF07974(EGF_2)PF17205(PSI_integrin) | 5 | GLU B 475GLY B 327THR A 348GLU A 315THR B 329 | None | 1.37A | 3r75B-4cakB:undetectable | 3r75B-4cakB:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gfh | DNA TOPOISOMERASE 2 (Saccharomycescerevisiae) |
PF00204(DNA_gyraseB)PF00521(DNA_topoisoIV)PF01751(Toprim)PF02518(HATPase_c)PF16898(TOPRIM_C) | 5 | GLU A 449ILE A 534SER A 532GLU A 679GLU A 558 | None | 1.16A | 3r75B-4gfhA:undetectable | 3r75B-4gfhA:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igb | LPXTG CELL WALLSURFACE PROTEIN (Streptococcusgordonii) |
no annotation | 5 | GLU D 232ILE D 222SER D 281GLY D 282THR D 271 | NA D 504 (-2.7A)NoneNoneNoneNone | 1.30A | 3r75B-4igbD:undetectable | 3r75B-4igbD:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4itx | CYSTATHIONINEBETA-LYASE METC (Escherichiacoli) |
PF01053(Cys_Met_Meta_PP) | 5 | ILE A 159SER A 158GLY A 157THR A 109GLU A 154 | NoneIN5 A 401 ( 4.0A)NoneNoneIN5 A 401 (-3.7A) | 1.49A | 3r75B-4itxA:undetectable | 3r75B-4itxA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oyd | APOPTOSIS REGULATORBHRF1 (Humangammaherpesvirus4) |
PF00452(Bcl-2) | 5 | ILE A 58SER A 62THR A 66GLU A 63HIS A 110 | None | 1.32A | 3r75B-4oydA:undetectable | 3r75B-4oydA:12.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rpf | HOMOSERINE KINASE (Yersinia pestis) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 5 | ILE A 259SER A 262GLY A 95SER A 183THR A 184 | NoneCIT A 401 (-3.0A)CIT A 401 (-3.3A)NoneCIT A 401 (-2.9A) | 1.40A | 3r75B-4rpfA:undetectable | 3r75B-4rpfA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uri | CHITINASE-RELATEDAGGLUTININ (Robiniapseudoacacia) |
PF00704(Glyco_hydro_18) | 5 | ILE A 162SER A 159GLY A 158THR A 184SER A 211 | NoneNoneNoneNoneMPD A 402 (-2.7A) | 1.40A | 3r75B-4uriA:undetectable | 3r75B-4uriA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwa | ANTHRANILATESYNTHASE COMPONENT 1 (Mycobacteriumtuberculosis) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 5 | GLU A 307ILE A 322GLY A 324THR A 325HIS A 388 | 0GA A 604 ( 4.5A)0GA A 604 ( 4.2A)None0GA A 604 ( 4.6A)0GA A 604 ( 4.3A) | 0.29A | 3r75B-5cwaA:33.8 | 3r75B-5cwaA:24.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ed1 | DOUBLE-STRANDEDRNA-SPECIFIC EDITASE1 (Homo sapiens) |
PF02137(A_deamin) | 5 | GLU A 396ILE A 446SER A 447GLY A 548GLU A 588 | ZN A 802 ( 4.2A)NoneNoneNoneNone | 1.40A | 3r75B-5ed1A:undetectable | 3r75B-5ed1A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gwj | DNA TOPOISOMERASE2-BETA (Homo sapiens) |
PF00521(DNA_topoisoIV)PF01751(Toprim)PF16898(TOPRIM_C) | 5 | GLU A 477ILE A 565SER A 563GLU A 718GLU A 588 | MG A1303 ( 4.3A)NoneNoneNoneNone | 1.02A | 3r75B-5gwjA:2.2 | 3r75B-5gwjA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hgg | CAMELID DERIVEDANTIBODY FRAGMENT,NB4 (Vicugna pacos) |
PF07686(V-set) | 5 | GLU S 115GLY S 102THR S 105ARG S 111SER S 108 | TWN S 202 (-3.5A)TWN S 202 ( 4.5A)NoneNoneNone | 1.06A | 3r75B-5hggS:undetectable | 3r75B-5hggS:11.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j84 | DIHYDROXY-ACIDDEHYDRATASE (Rhizobiumleguminosarum) |
PF00920(ILVD_EDD) | 5 | SER A 276GLY A 481THR A 482SER A 207THR A 208 | None | 1.50A | 3r75B-5j84A:undetectable | 3r75B-5j84A:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jpn | COMPLEMENT C4-A (Homo sapiens) |
PF01835(A2M_N)PF07703(A2M_N_2) | 5 | GLU A 392SER A 399GLY A 400THR A 425SER A 428 | None | 1.40A | 3r75B-5jpnA:undetectable | 3r75B-5jpnA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jy9 | PUTATIVE SALICYLATESYNTHETASE (Yersiniaenterocolitica) |
PF00425(Chorismate_bind) | 8 | GLU A 240GLY A 257THR A 258GLU A 284HIS A 321ARG A 391GLU A 420LYS A 424 | NoneACT A 503 (-3.2A)ACT A 503 (-3.7A)FE2 A 501 ( 2.7A)ACT A 503 ( 4.1A)ACT A 502 (-3.5A)FE2 A 501 ( 2.8A)ACT A 503 ( 2.3A) | 0.43A | 3r75B-5jy9A:43.4 | 3r75B-5jy9A:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jy9 | PUTATIVE SALICYLATESYNTHETASE (Yersiniaenterocolitica) |
PF00425(Chorismate_bind) | 5 | GLY A 257THR A 258HIS A 321ARG A 391THR A 348 | ACT A 503 (-3.2A)ACT A 503 (-3.7A)ACT A 503 ( 4.1A)ACT A 502 (-3.5A)None | 1.10A | 3r75B-5jy9A:43.4 | 3r75B-5jy9A:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jzd | ISOCHORISMATESYNTHASE ENTC (Escherichiacoli) |
PF00425(Chorismate_bind) | 7 | GLU A 197GLY A 214GLU A 241HIS A 276ARG A 347GLU A 376LYS A 380 | ISC A 401 (-3.0A)ISC A 401 (-3.2A) MG A 402 ( 2.4A)ISC A 401 (-3.5A)ISC A 401 (-3.5A) MG A 402 ( 2.6A)ISC A 401 (-3.0A) | 0.48A | 3r75B-5jzdA:39.2 | 3r75B-5jzdA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ken | C4G7 VARIABLE FABDOMAIN HEAVY CHAIN (Homo sapiens) |
PF07686(V-set) | 5 | GLU C 12GLY C 8THR C 107SER C 21GLU C 6 | None | 1.48A | 3r75B-5kenC:undetectable | 3r75B-5kenC:12.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lji | FLAVODOXIN (Streptococcuspneumoniae) |
PF00258(Flavodoxin_1) | 5 | GLU A 67SER A 10GLY A 13THR A 12SER A 90 | NoneFMN A 201 (-2.5A)FMN A 201 (-4.1A)FMN A 201 (-3.3A)FMN A 201 (-2.8A) | 1.45A | 3r75B-5ljiA:6.4 | 3r75B-5ljiA:13.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lji | FLAVODOXIN (Streptococcuspneumoniae) |
PF00258(Flavodoxin_1) | 5 | GLU A 67SER A 10THR A 12SER A 90THR A 15 | NoneFMN A 201 (-2.5A)FMN A 201 (-3.3A)FMN A 201 (-2.8A)FMN A 201 (-3.6A) | 1.49A | 3r75B-5ljiA:6.4 | 3r75B-5ljiA:13.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m9f | ORF68 (Staphylococcusvirus K) |
no annotation | 5 | SER A 409GLY A 410THR A 380GLU A 378THR A 377 | None | 1.45A | 3r75B-5m9fA:undetectable | 3r75B-5m9fA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mrw | POTASSIUM-TRANSPORTING ATPASEPOTASSIUM-BINDINGSUBUNIT (Escherichiacoli) |
PF03814(KdpA) | 5 | ILE A 398GLY A 518THR A 519THR A 401GLU A 403 | None | 1.39A | 3r75B-5mrwA:undetectable | 3r75B-5mrwA:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oyn | DEHYDRATASE,ILVD/EDD FAMILY (Caulobactervibrioides) |
no annotation | 5 | SER A 277GLY A 491THR A 492SER A 208THR A 209 | None | 1.49A | 3r75B-5oynA:undetectable | 3r75B-5oynA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5udb | DNA REPLICATIONLICENSING FACTORMCM2CELL DIVISION CYCLEPROTEIN CDT1 (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF00493(MCM)PF14551(MCM_N)PF17207(MCM_OB)PF16679(CDT1_C) | 5 | GLU 2 251GLY 2 223THR 2 222SER 8 210THR 8 211 | None | 1.36A | 3r75B-5udb2:undetectable | 3r75B-5udb2:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wbl | REGULATORY-ASSOCIATED PROTEIN OF TOR 1 (Arabidopsisthaliana) |
no annotation | 5 | GLU A 711ILE A 966GLY A 968GLU A 91LYS A 622 | None | 1.12A | 3r75B-5wblA:2.8 | 3r75B-5wblA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bnp | UNCONVENTIONALMYOSIN-VI (Sus scrofa) |
no annotation | 5 | ILE I 147SER I 146GLY I 453SER I 144THR I 661 | None | 1.36A | 3r75B-6bnpI:undetectable | 3r75B-6bnpI:undetectable |