SIMILAR PATTERNS OF AMINO ACIDS FOR 3R6W_A_NFZA214

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR

(Bos taurus) 		PF00996
(GDI) 		5 VAL A 147
TYR A 172
PHE A 143
PHE A 140
PHE A 184
 None
 1.50A 3r6wA-1d5tA:
2.6
3r6wB-1d5tA:
undetectable		 3r6wA-1d5tA:
19.86
3r6wB-1d5tA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gan GALECTIN-1

(Rhinella
arenarum) 		PF00337
(Gal-bind_lectin) 		5 PHE A 107
VAL A  88
PHE A 101
PHE A  80
PHE A  31
 None
 1.37A 3r6wA-1ganA:
undetectable
3r6wB-1ganA:
undetectable		 3r6wA-1ganA:
19.02
3r6wB-1ganA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 VAL A 828
PHE A 843
TYR A 893
GLY A 699
PHE A 674
 None
 1.39A 3r6wA-1i8qA:
undetectable
3r6wB-1i8qA:
undetectable		 3r6wA-1i8qA:
13.73
3r6wB-1i8qA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 VAL A 731
PHE A 746
TYR A 795
GLY A 619
PHE A 594
 None
 1.33A 3r6wA-1n7rA:
0.0
3r6wB-1n7rA:
undetectable		 3r6wA-1n7rA:
14.87
3r6wB-1n7rA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		5 PHE A 233
TYR A 215
PHE A 238
GLY A 213
ASN A 246
 None
 1.47A 3r6wA-1pyfA:
0.7
3r6wB-1pyfA:
2.5		 3r6wA-1pyfA:
21.56
3r6wB-1pyfA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t11 TRIGGER FACTOR

(Vibrio cholerae) 		PF00254
(FKBP_C)
PF05697
(Trigger_N)
PF05698
(Trigger_C) 		5 PHE A 185
PHE A 168
PHE A 233
GLY A 179
PHE A 177
 None
 1.49A 3r6wA-1t11A:
undetectable
3r6wB-1t11A:
undetectable		 3r6wA-1t11A:
20.71
3r6wB-1t11A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uas ALPHA-GALACTOSIDASE

(Oryza sativa) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		5 PHE A 159
TYR A 129
PHE A 119
GLY A 107
PHE A  65
 None
 1.48A 3r6wA-1uasA:
0.0
3r6wB-1uasA:
1.2		 3r6wA-1uasA:
20.66
3r6wB-1uasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		5 PHE A 391
TYR A 707
PHE A 711
GLY A 582
ASN A 651
 None
 1.20A 3r6wA-1w6jA:
undetectable
3r6wB-1w6jA:
undetectable		 3r6wA-1w6jA:
14.87
3r6wB-1w6jA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00155
(Aminotran_1_2) 		5 VAL A 326
PHE A 228
GLY A  38
PHE A 360
ASN A 194
 None
None
5PV  A 414 (-3.3A)
5PV  A 414 (-4.5A)
5PV  A 414 ( 3.3A)
 1.24A 3r6wA-2ay9A:
1.3
3r6wB-2ay9A:
3.0		 3r6wA-2ay9A:
20.84
3r6wB-2ay9A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw2 SUPEROXIDE DISMUTASE
1

(Perkinsus
marinus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 PHE A 113
VAL A 192
ASN A  86
PHE A  82
ASN A 149
 None
 1.37A 3r6wA-2cw2A:
undetectable
3r6wB-2cw2A:
undetectable		 3r6wA-2cw2A:
22.45
3r6wB-2cw2A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdn ELONGATION FACTOR
EF-TU

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 PHE B 322
VAL B 308
PHE B 374
PHE B 304
GLY B 339
 None
 1.44A 3r6wA-2hdnB:
5.3
3r6wB-2hdnB:
undetectable		 3r6wA-2hdnB:
21.92
3r6wB-2hdnB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8o REGULATOR OF
RIBONUCLEASE
ACTIVITY A

(Pseudomonas
aeruginosa) 		PF03737
(RraA-like) 		5 PHE A 138
VAL A  60
PHE A  32
GLY A 150
ASN A 148
 None
None
None
PEG  A 190 ( 4.0A)
None
 1.38A 3r6wA-3c8oA:
undetectable
3r6wB-3c8oA:
undetectable		 3r6wA-3c8oA:
19.56
3r6wB-3c8oA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cm5 CELL DEATH-RELATED
NUCLEASE 4

(Caenorhabditis
elegans) 		PF00929
(RNase_T) 		5 VAL A  31
PHE A  85
TYR A  89
PHE A  34
PHE A 108
 None
 1.30A 3r6wA-3cm5A:
undetectable
3r6wB-3cm5A:
undetectable		 3r6wA-3cm5A:
21.73
3r6wB-3cm5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlc PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE

(Methanococcus
maripaludis) 		PF08241
(Methyltransf_11) 		5 PHE A 130
PHE A 185
PHE A 206
GLY A 118
ASN A 176
 None
None
None
SAM  A 220 (-4.7A)
None
 1.22A 3r6wA-3dlcA:
undetectable
3r6wB-3dlcA:
undetectable		 3r6wA-3dlcA:
23.14
3r6wB-3dlcA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e73 LANC-LIKE PROTEIN 1

(Homo sapiens) 		PF05147
(LANC_like) 		5 VAL A 116
PHE A 164
TYR A 160
PHE A 106
PHE A 373
 None
 1.32A 3r6wA-3e73A:
undetectable
3r6wB-3e73A:
undetectable		 3r6wA-3e73A:
19.56
3r6wB-3e73A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 VAL A  30
PHE A  46
PHE A  53
GLY A  11
ASN A  39
 None
 1.29A 3r6wA-3i23A:
undetectable
3r6wB-3i23A:
3.5		 3r6wA-3i23A:
22.81
3r6wB-3i23A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilr HEPARIN LYASE I

(Bacteroides
thetaiotaomicron) 		PF14099
(Polysacc_lyase) 		5 PHE A 238
PHE A 295
PHE A 131
PHE A 352
GLY A 355
 None
 1.36A 3r6wA-3ilrA:
undetectable
3r6wB-3ilrA:
undetectable		 3r6wA-3ilrA:
19.19
3r6wB-3ilrA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp ELONGATION FACTOR TU
2, ELONGATION FACTOR
TS

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 PHE A1322
VAL A1308
PHE A1374
PHE A1304
GLY A1339
 None
 1.49A 3r6wA-3mmpA:
7.0
3r6wB-3mmpA:
5.4		 3r6wA-3mmpA:
13.99
3r6wB-3mmpA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9o PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF02373
(JmjC) 		5 PHE A 582
PHE A 442
PHE A 339
PHE A 356
GLY A 353
 None
 1.33A 3r6wA-3n9oA:
undetectable
3r6wB-3n9oA:
undetectable		 3r6wA-3n9oA:
18.62
3r6wB-3n9oA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF08005
(PHR) 		5 VAL A 397
PHE A 499
PHE A 395
GLY A 405
PHE A 453
 None
 1.46A 3r6wA-3no8A:
undetectable
3r6wB-3no8A:
undetectable		 3r6wA-3no8A:
19.09
3r6wB-3no8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o53 PROTEIN LRIM1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 VAL A 286
PHE A 264
PHE A 257
ASN A 283
GLY A 229
 None
 1.21A 3r6wA-3o53A:
undetectable
3r6wB-3o53A:
undetectable		 3r6wA-3o53A:
20.57
3r6wB-3o53A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Francisella
tularensis) 		PF00342
(PGI) 		5 VAL A 392
PHE A 394
TYR A 329
PHE A 379
ASN A 374
 None
 1.38A 3r6wA-3q88A:
3.0
3r6wB-3q88A:
2.6		 3r6wA-3q88A:
18.01
3r6wB-3q88A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryl PROTEIN VPA1370

(Vibrio
parahaemolyticus) 		no annotation 5 PHE A 424
PHE A 406
GLY A 430
PHE A 448
ASN A 452
 None
 1.33A 3r6wA-3rylA:
undetectable
3r6wB-3rylA:
undetectable		 3r6wA-3rylA:
22.35
3r6wB-3rylA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 PHE A 233
PHE A 525
PHE A 203
GLY A 192
ASN A 206
 None
 1.44A 3r6wA-3vu2A:
0.9
3r6wB-3vu2A:
undetectable		 3r6wA-3vu2A:
15.54
3r6wB-3vu2A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs3 THAUMATIN-LIKE
PROTEIN

(Malus domestica) 		PF00314
(Thaumatin) 		5 VAL A  91
PHE A  51
PHE A   5
GLY A  30
PHE A  31
 None
None
None
SIN  A1223 (-4.4A)
None
 1.34A 3r6wA-3zs3A:
undetectable
3r6wB-3zs3A:
undetectable		 3r6wA-3zs3A:
21.60
3r6wB-3zs3A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3s PUTATIVE PERIPLASMIC
BINDING PROTEIN

(Salmonella
enterica) 		PF00497
(SBP_bac_3) 		5 VAL A  13
TYR A  42
PHE A  39
PHE A 202
ASN A 213
 None
 1.50A 3r6wA-4f3sA:
undetectable
3r6wB-4f3sA:
undetectable		 3r6wA-4f3sA:
22.10
3r6wB-4f3sA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksf MALONYL-COA
DECARBOXYLASE

(Agrobacterium
vitis) 		PF05292
(MCD)
PF17408
(MCD_N) 		5 VAL A 232
PHE A 263
GLY A 279
PHE A 380
ASN A 384
 None
 1.38A 3r6wA-4ksfA:
undetectable
3r6wB-4ksfA:
undetectable		 3r6wA-4ksfA:
21.14
3r6wB-4ksfA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n9q FMN-DEPENDENT
NADH-AZOREDUCTASE 1

(Pseudomonas
aeruginosa) 		PF02525
(Flavodoxin_2) 		5 ASN A  99
PHE A 100
GLY A 148
PHE A 151
ASN A 157
 FMN  A 301 (-2.9A)
FMN  A 301 (-3.9A)
FMN  A 301 (-3.6A)
FMN  A 301 (-3.8A)
None
 0.19A 3r6wA-4n9qA:
35.7
3r6wB-4n9qA:
34.2		 3r6wA-4n9qA:
100.00
3r6wB-4n9qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n9q FMN-DEPENDENT
NADH-AZOREDUCTASE 1

(Pseudomonas
aeruginosa) 		PF02525
(Flavodoxin_2) 		5 PHE A  60
VAL A 114
PHE A 120
TYR A 131
PHE A 173
 UQ1  A 302 (-4.4A)
None
UQ1  A 302 (-3.9A)
UQ1  A 302 (-3.7A)
UQ1  A 302 (-3.0A)
 0.13A 3r6wA-4n9qA:
35.7
3r6wB-4n9qA:
34.2		 3r6wA-4n9qA:
100.00
3r6wB-4n9qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uac CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-)

([Eubacterium]
rectale) 		PF13416
(SBP_bac_8) 		5 PHE A 301
TYR A 217
PHE A 219
PHE A 413
GLY A 381
 None
None
PEG  A 502 (-4.3A)
None
None
 1.32A 3r6wA-4uacA:
undetectable
3r6wB-4uacA:
undetectable		 3r6wA-4uacA:
20.30
3r6wB-4uacA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		5 PHE A 473
VAL A 465
PHE A 463
PHE A 608
PHE A 658
 None
 1.21A 3r6wA-5azaA:
undetectable
3r6wB-5azaA:
undetectable		 3r6wA-5azaA:
13.36
3r6wB-5azaA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl5 MEMBRANE PROTEIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		5 TYR A 238
ASN A 260
PHE A 231
GLY A 292
ASN A 294
 None
 1.33A 3r6wA-5dl5A:
undetectable
3r6wB-5dl5A:
undetectable		 3r6wA-5dl5A:
18.62
3r6wB-5dl5A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		5 PHE A 380
VAL A  94
PHE A  85
PHE A  71
GLY A  65
 X2N  A 590 ( 4.8A)
None
None
None
X2N  A 590 ( 4.0A)
 1.38A 3r6wA-5fsaA:
undetectable
3r6wB-5fsaA:
undetectable		 3r6wA-5fsaA:
18.76
3r6wB-5fsaA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyd OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Collinsella
aerofaciens) 		PF00106
(adh_short) 		5 VAL A 138
PHE A  87
ASN A 140
GLY A  15
PHE A  67
 None
 1.36A 3r6wA-5fydA:
4.0
3r6wB-5fydA:
4.3		 3r6wA-5fydA:
23.25
3r6wB-5fydA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN

(Streptococcus
suis) 		PF05833
(FbpA) 		5 PHE A 244
PHE A 225
PHE A 226
GLY A 201
ASN A 172
 None
 1.40A 3r6wA-5h3xA:
undetectable
3r6wB-5h3xA:
undetectable		 3r6wA-5h3xA:
22.35
3r6wB-5h3xA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 5 ASN A 151
PHE A 154
GLY A 188
PHE A 145
ASN A 142
 None
 1.36A 3r6wA-5hdtA:
undetectable
3r6wB-5hdtA:
undetectable		 3r6wA-5hdtA:
10.93
3r6wB-5hdtA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Arabidopsis
thaliana) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5)
PF13431
(TPR_17) 		5 PHE A 462
VAL A 229
TYR A 252
PHE A 254
GLY A 244
 None
 1.35A 3r6wA-5jjtA:
undetectable
3r6wB-5jjtA:
undetectable		 3r6wA-5jjtA:
18.37
3r6wB-5jjtA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9i TRANSCRIPTION
INITIATION FACTOR
IIB,TRANSCRIPTION
INITIATION FACTOR
IIB

(Methanocaldococcus
vulcanius) 		no annotation 5 VAL A 187
PHE A  54
TYR A  58
PHE A 150
PHE A 152
 None
 0.92A 3r6wA-5o9iA:
undetectable
3r6wB-5o9iA:
undetectable		 3r6wA-5o9iA:
19.67
3r6wB-5o9iA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME

(Homo sapiens) 		PF06859
(Bin3)
PF13847
(Methyltransf_31) 		5 TYR A 490
PHE A 549
ASN A 552
GLY A 455
PHE A 555
 None
 1.22A 3r6wA-5unaA:
undetectable
3r6wB-5unaA:
2.5		 3r6wA-5unaA:
21.55
3r6wB-5unaA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT

(Saccharomyces
cerevisiae) 		no annotation 5 PHE G 120
VAL G 222
PHE G 224
PHE G 201
ASN G 193
 None
 1.34A 3r6wA-5uz5G:
undetectable
3r6wB-5uz5G:
undetectable		 3r6wA-5uz5G:
18.22
3r6wB-5uz5G:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w76 ANCESTRAL ELOGATION
FACTOR N153

(synthetic
construct) 		no annotation 5 PHE A 323
VAL A 309
PHE A 375
PHE A 305
GLY A 340
 None
 1.42A 3r6wA-5w76A:
4.1
3r6wB-5w76A:
6.4		 3r6wA-5w76A:
15.20
3r6wB-5w76A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)

(Helicobacter
pylori) 		no annotation 5 PHE A 268
PHE A 182
GLY A  66
PHE A  93
ASN A  97
 None
 0.91A 3r6wA-5wbfA:
undetectable
3r6wB-5wbfA:
undetectable		 3r6wA-5wbfA:
20.73
3r6wB-5wbfA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE

(Homo sapiens) 		no annotation 5 PHE A 177
VAL A 167
PHE A 199
PHE A 120
PHE A 115
 None
 1.47A 3r6wA-5wy0A:
undetectable
3r6wB-5wy0A:
1.8		 3r6wA-5wy0A:
15.24
3r6wB-5wy0A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE

(Homo sapiens) 		no annotation 5 PHE A  89
VAL A 201
PHE A 102
GLY A 124
ASN A 108
 None
 1.38A 3r6wA-6dd3A:
1.6
3r6wB-6dd3A:
undetectable		 3r6wA-6dd3A:
20.00
3r6wB-6dd3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 PHE A  67
PHE A  58
TYR A 136
GLY A 166
PHE A 223
 None
 1.34A 3r6wA-6eu6A:
undetectable
3r6wB-6eu6A:
undetectable		 3r6wA-6eu6A:
17.48
3r6wB-6eu6A:
17.48