SIMILAR PATTERNS OF AMINO ACIDS FOR 3R4X_A_PZAA598

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 ARG C 239
GLU C 242
PHE C 366
PRO C 220
 HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
None
 1.38A 3r4xA-1d7wC:
34.6		 3r4xA-1d7wC:
45.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1c HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		4 PHE A 179
ARG A 262
GLU A 261
PRO A  30
 None
 1.38A 3r4xA-1h1cA:
0.0		 3r4xA-1h1cA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6o TATD-RELATED
DEOXYRIBONUCLEASE

(Thermotoga
maritima) 		PF01026
(TatD_DNase) 		4 PHE A  12
ARG A  16
PHE A  23
PRO A 217
 None
 1.50A 3r4xA-1j6oA:
0.0		 3r4xA-1j6oA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz1 GENERAL STRESS
PROTEIN 69

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		4 PHE A  95
ARG A 328
GLU A 329
PRO A 332
 None
 1.38A 3r4xA-1pz1A:
0.0		 3r4xA-1pz1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ARG A  56
GLU A 238
PHE A 240
PRO A  60
 None
 1.47A 3r4xA-1we5A:
0.0		 3r4xA-1we5A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x87 UROCANASE PROTEIN

(Geobacillus
stearothermophilus) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 PHE A 356
ARG A 413
GLU A 412
PHE A 379
 None
 1.11A 3r4xA-1x87A:
0.0		 3r4xA-1x87A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8o SAM DOMAIN AND HD
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF07647
(SAM_2) 		4 PHE A  71
ARG A  82
GLU A  81
PHE A  44
 None
 1.31A 3r4xA-2e8oA:
undetectable		 3r4xA-2e8oA:
12.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gjm LACTOPEROXIDASE

(Bubalus bubalis) 		PF03098
(An_peroxidase) 		5 PHE A 238
ARG A 239
GLU A 242
PHE A 366
PRO A 409
 None
HEM  A 605 (-4.7A)
HEM  A 605 ( 2.2A)
None
None
 0.71A 3r4xA-2gjmA:
60.9		 3r4xA-2gjmA:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		4 PHE A 627
ARG A 628
GLU A 632
PRO A 654
 None
 0.97A 3r4xA-3d3lA:
0.0		 3r4xA-3d3lA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		4 PHE A 105
ARG A  73
GLU A  74
PHE A  45
 None
 1.38A 3r4xA-3ie1A:
0.0		 3r4xA-3ie1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 PHE A 637
ARG A 638
GLU A 642
PRO A 664
 None
 0.92A 3r4xA-3v98A:
undetectable		 3r4xA-3v98A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA

(Bacillus
subtilis) 		PF01041
(DegT_DnrJ_EryC1) 		4 ARG A 426
GLU A 423
PHE A 419
PRO A 414
 None
 1.32A 3r4xA-4k2bA:
undetectable		 3r4xA-4k2bA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)

(Streptococcus
agalactiae) 		PF10425
(SdrG_C_C) 		4 ARG A 464
GLU A 463
PHE A 450
PRO A 435
 None
 1.46A 3r4xA-4mboA:
undetectable		 3r4xA-4mboA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wdr HALOALKANE
DEHALOGENASE

(Sphingobium
japonicum) 		PF00561
(Abhydrolase_1) 		4 PHE A  34
GLU A  26
PHE A   8
PRO A  50
 None
 1.32A 3r4xA-4wdrA:
undetectable		 3r4xA-4wdrA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqm GENERAL
TRANSCRIPTION AND
DNA REPAIR FACTOR
IIH HELICASE SUBUNIT
XPB

(Saccharomyces
cerevisiae) 		no annotation 4 ARG 7 757
GLU 7 564
PHE 7 565
PRO 7 585
 None
 1.49A 3r4xA-5oqm7:
undetectable		 3r4xA-5oqm7:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t67 SUGAR 3-C-METHYL
TRANSFERASE

(Actinomadura
kijaniata) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 ARG A 398
GLU A 394
PHE A 371
PRO A 376
 None
 1.43A 3r4xA-5t67A:
undetectable		 3r4xA-5t67A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Homo sapiens) 		no annotation 4 ARG C 172
GLU C  32
PHE C 272
PRO C 270
 None
 1.25A 3r4xA-6cajC:
2.2		 3r4xA-6cajC:
undetectable