SIMILAR PATTERNS OF AMINO ACIDS FOR 3R2J_C_NIOC311
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dqu | ISOCITRATE LYASE (Aspergillusnidulans) |
PF00463(ICL) | 5 | ASP A 168LEU A 182ASP A 170HIS A 173ALA A 167 | None | 1.30A | 3r2jC-1dquA:undetectable | 3r2jC-1dquA:19.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1im5 | 180AA LONGHYPOTHETICALPYRAZINAMIDASE/NICOTINAMIDASE (Pyrococcushorikoshii) |
PF00857(Isochorismatase) | 10 | ASP A 10PHE A 15LEU A 21ASP A 52HIS A 54TRP A 68HIS A 71LYS A 94TYR A 103ALA A 129 | NoneNoneNone ZN A 400 (-2.5A) ZN A 400 (-3.3A)None ZN A 400 (-3.4A)NoneNoneNone | 0.52A | 3r2jC-1im5A:28.4 | 3r2jC-1im5A:34.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1im5 | 180AA LONGHYPOTHETICALPYRAZINAMIDASE/NICOTINAMIDASE (Pyrococcushorikoshii) |
PF00857(Isochorismatase) | 5 | ASP A 10PHE A 15LYS A 94ALA A 129CYH A 133 | None | 1.19A | 3r2jC-1im5A:28.4 | 3r2jC-1im5A:34.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nf9 | PHENAZINEBIOSYNTHESIS PROTEINPHZD (Pseudomonasaeruginosa) |
PF00857(Isochorismatase) | 5 | ASP A 38PHE A 43TRP A 94LYS A 122TYR A 125 | NoneNoneFMT A 210 ( 4.4A)NoneNone | 0.84A | 3r2jC-1nf9A:20.2 | 3r2jC-1nf9A:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rf5 | 5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATESYNTHASE (Streptococcuspneumoniae) |
PF00275(EPSP_synthase) | 5 | ASP A 419LEU A 424TRP A 239TYR A 414PHE A 417 | None | 1.46A | 3r2jC-1rf5A:undetectable | 3r2jC-1rf5A:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rrm | LACTALDEHYDEREDUCTASE (Escherichiacoli) |
PF00465(Fe-ADH) | 5 | LEU A 259ASP A 196HIS A 277HIS A 263ALA A 250 | FE2 A 388 ( 4.1A) ZN A 387 (-2.6A) ZN A 387 (-3.3A) ZN A 387 ( 3.3A)None | 1.22A | 3r2jC-1rrmA:undetectable | 3r2jC-1rrmA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fq1 | ISOCHORISMATASE (Escherichiacoli) |
PF00550(PP-binding)PF00857(Isochorismatase) | 5 | ASP A 37PHE A 42TRP A 95LYS A 123TYR A 126 | None | 0.95A | 3r2jC-2fq1A:19.8 | 3r2jC-2fq1A:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h0r | NICOTINAMIDASE (Saccharomycescerevisiae) |
PF00857(Isochorismatase) | 10 | ASP A 8PHE A 13LEU A 20ASP A 51HIS A 53TRP A 91HIS A 94LYS A 122TYR A 131ALA A 163 | NoneNoneNone ZN A 301 (-2.6A) ZN A 301 (-3.2A)None ZN A 301 (-3.4A)NoneNoneNone | 0.30A | 3r2jC-2h0rA:28.4 | 3r2jC-2h0rA:28.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ppt | THIOREDOXIN-2 (Rhodobactercapsulatus) |
PF00085(Thioredoxin) | 5 | PHE A 119LEU A 140ASP A 67ALA A 134CYH A 76 | None | 1.49A | 3r2jC-2pptA:undetectable | 3r2jC-2pptA:24.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wt9 | NICOTINAMIDASE (Acinetobacterbaumannii) |
PF00857(Isochorismatase) | 5 | ASP A 16ASP A 54HIS A 89TYR A 123PHE A 158 | NIO A1216 (-3.8A) ZN A1212 ( 2.6A) ZN A1212 ( 3.5A)NIO A1216 (-4.9A)None | 1.32A | 3r2jC-2wt9A:30.3 | 3r2jC-2wt9A:37.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wt9 | NICOTINAMIDASE (Acinetobacterbaumannii) |
PF00857(Isochorismatase) | 11 | ASP A 16PHE A 21LEU A 27ASP A 54HIS A 56TRP A 86HIS A 89LYS A 114TYR A 123ALA A 155PHE A 158 | NIO A1216 (-3.8A)NIO A1216 (-3.7A)None ZN A1212 ( 2.6A) ZN A1212 (-3.4A)NIO A1216 (-3.3A) ZN A1212 ( 3.5A)NIO A1216 ( 4.5A)NIO A1216 (-4.9A)NIO A1216 (-3.8A)None | 0.45A | 3r2jC-2wt9A:30.3 | 3r2jC-2wt9A:37.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2b | DIHYDROOROTASE (Escherichiacoli) |
PF01979(Amidohydro_1) | 5 | ASP A 240HIS A 16HIS A 18ALA A 256CYH A 211 | ZN A 338 (-2.7A) ZN A 338 (-3.4A) ZN A 338 (-3.2A)NoneNone | 1.07A | 3r2jC-2z2bA:undetectable | 3r2jC-2z2bA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bfj | 1,3-PROPANEDIOLOXIDOREDUCTASE (Klebsiellapneumoniae) |
PF00465(Fe-ADH) | 5 | LEU A 263ASP A 198HIS A 281HIS A 267ALA A 254 | NoneFE2 A1388 (-2.6A)FE2 A1388 (-3.6A)FE2 A1388 (-3.2A)None | 1.24A | 3r2jC-3bfjA:4.2 | 3r2jC-3bfjA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eef | N-CARBAMOYLSARCOSINEAMIDASE RELATEDPROTEIN (Thermoplasmaacidophilum) |
PF00857(Isochorismatase) | 8 | ASP A 9PHE A 14ASP A 50HIS A 52TRP A 62HIS A 65LYS A 90TYR A 93 | NoneNone ZN A 183 (-2.6A) ZN A 183 (-3.4A)None ZN A 183 (-3.4A)NoneNone | 0.65A | 3r2jC-3eefA:23.2 | 3r2jC-3eefA:25.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hb7 | ISOCHORISMATASEHYDROLASE (Alkaliphilusmetalliredigens) |
PF00857(Isochorismatase) | 6 | ASP A 10PHE A 15LEU A 22HIS A 58LYS A 96CYH A 129 | NoneNoneNoneNH4 A 201 (-4.1A)NoneNone | 1.38A | 3r2jC-3hb7A:22.5 | 3r2jC-3hb7A:25.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3hu5 | ISOCHORISMATASEFAMILY PROTEIN (Desulfovibriovulgaris) |
PF00857(Isochorismatase) | 5 | ASP A 15PHE A 20HIS A 60LYS A 106CYH A 139 | None | 0.99A | 3r2jC-3hu5A:23.8 | 3r2jC-3hu5A:30.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3irv | CYSTEINE HYDROLASE (Pseudomonassavastanoi) |
PF00857(Isochorismatase) | 5 | ASP A 56PHE A 61LEU A 68LYS A 146TYR A 149 | None | 0.66A | 3r2jC-3irvA:23.3 | 3r2jC-3irvA:24.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jze | DIHYDROOROTASE (Salmonellaenterica) |
PF01979(Amidohydro_1) | 5 | ASP A 251HIS A 17HIS A 19ALA A 267CYH A 222 | ZN A 401 (-2.7A) ZN A 401 (-3.3A) ZN A 401 ( 3.3A)NoneNone | 1.11A | 3r2jC-3jzeA:undetectable | 3r2jC-3jzeA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o90 | NICOTINAMIDASE (Streptococcuspneumoniae) |
PF00857(Isochorismatase) | 7 | ASP A 9PHE A 14LEU A 21ASP A 53HIS A 55HIS A 71TYR A 106 | NoneNoneNone ZN A 192 (-2.3A) ZN A 192 (-3.3A) ZN A 192 (-3.2A)None | 0.55A | 3r2jC-3o90A:23.1 | 3r2jC-3o90A:28.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o90 | NICOTINAMIDASE (Streptococcuspneumoniae) |
PF00857(Isochorismatase) | 7 | ASP A 9PHE A 14LEU A 21ASP A 53HIS A 71LYS A 103TYR A 106 | NoneNoneNone ZN A 192 (-2.3A) ZN A 192 (-3.2A)NoneNone | 0.58A | 3r2jC-3o90A:23.1 | 3r2jC-3o90A:28.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ox4 | ALCOHOLDEHYDROGENASE 2 (Zymomonasmobilis) |
PF00465(Fe-ADH) | 5 | LEU A 259ASP A 194HIS A 277HIS A 263ALA A 250 | NoneFE2 A 501 (-2.2A)NAD A1385 ( 3.6A)FE2 A 501 (-3.3A)None | 1.34A | 3r2jC-3ox4A:3.8 | 3r2jC-3ox4A:22.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pl1 | PYRAZINAMIDASE/NICOTINAMIDASE PNCA(PZASE) (Mycobacteriumtuberculosis) |
PF00857(Isochorismatase) | 5 | ASP A 8ASP A 49HIS A 71ALA A 134CYH A 138 | NoneFE2 A 188 (-2.6A)FE2 A 188 (-3.4A)NoneNone | 1.30A | 3r2jC-3pl1A:25.8 | 3r2jC-3pl1A:36.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pl1 | PYRAZINAMIDASE/NICOTINAMIDASE PNCA(PZASE) (Mycobacteriumtuberculosis) |
PF00857(Isochorismatase) | 9 | ASP A 8PHE A 13LEU A 19ASP A 49HIS A 51TRP A 68HIS A 71LYS A 96CYH A 138 | NoneNoneNoneFE2 A 188 (-2.6A)FE2 A 188 (-3.5A)NoneFE2 A 188 (-3.4A)NoneNone | 0.63A | 3r2jC-3pl1A:25.8 | 3r2jC-3pl1A:36.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pl1 | PYRAZINAMIDASE/NICOTINAMIDASE PNCA(PZASE) (Mycobacteriumtuberculosis) |
PF00857(Isochorismatase) | 9 | ASP A 8PHE A 13LEU A 19ASP A 49TRP A 68HIS A 71LYS A 96ALA A 134CYH A 138 | NoneNoneNoneFE2 A 188 (-2.6A)NoneFE2 A 188 (-3.4A)NoneNoneNone | 0.77A | 3r2jC-3pl1A:25.8 | 3r2jC-3pl1A:36.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pl1 | PYRAZINAMIDASE/NICOTINAMIDASE PNCA(PZASE) (Mycobacteriumtuberculosis) |
PF00857(Isochorismatase) | 5 | LEU A 19HIS A 57HIS A 71ALA A 134CYH A 138 | NoneFE2 A 188 (-3.5A)FE2 A 188 (-3.4A)NoneNone | 1.15A | 3r2jC-3pl1A:25.8 | 3r2jC-3pl1A:36.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pnu | DIHYDROOROTASE (Campylobacterjejuni) |
PF04909(Amidohydro_2) | 5 | ASP A 237HIS A 10HIS A 12ALA A 253CYH A 208 | ZN A 337 (-2.9A) ZN A 337 (-3.3A) ZN A 337 (-3.4A)NoneNone | 1.02A | 3r2jC-3pnuA:undetectable | 3r2jC-3pnuA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s2s | PUTATIVEPYRAZINAMIDASE/NICOTINAMIDASE (Streptococcusmutans) |
PF00857(Isochorismatase) | 8 | ASP A 9PHE A 14LEU A 21ASP A 53HIS A 55HIS A 71LYS A 103TYR A 106 | CAD A 185 (-3.7A)CAD A 185 (-3.3A)None ZN A 184 (-2.6A) ZN A 184 (-3.3A) ZN A 184 (-3.4A)NoneNone | 0.44A | 3r2jC-3s2sA:22.9 | 3r2jC-3s2sA:28.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tb4 | VIBRIOBACTIN-SPECIFIC ISOCHORISMATASE (Vibrio cholerae) |
PF00857(Isochorismatase) | 5 | ASP A 35PHE A 40TRP A 93LYS A 118TYR A 121 | NoneBOG A 501 (-4.5A)BOG A 501 ( 2.7A)NoneBOG A 501 (-4.1A) | 0.84A | 3r2jC-3tb4A:19.5 | 3r2jC-3tb4A:24.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uw2 | PHOSPHOGLUCOMUTASE/PHOSPHOMANNOMUTASEFAMILY PROTEIN (Burkholderiathailandensis) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | ASP A 245ASP A 247HIS A 330ALA A 185PHE A 242 | ZN A 474 (-2.6A) ZN A 474 ( 2.5A)NoneNoneNone | 1.42A | 3r2jC-3uw2A:undetectable | 3r2jC-3uw2A:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vz0 | PUTATIVENAD-DEPENDENTALDEHYDEDEHYDROGENASE (Gluconobacteroxydans) |
PF00171(Aldedh) | 5 | ASP A 174LEU A 60HIS A 67ALA A 175PHE A 172 | None | 1.19A | 3r2jC-3vz0A:3.4 | 3r2jC-3vz0A:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zdr | ALCOHOLDEHYDROGENASE DOMAINOF THE BIFUNCTIONALACETALDEHYDEDEHYDROGENASE (Parageobacillusthermoglucosidasius) |
PF00465(Fe-ADH) | 5 | LEU A 726ASP A 661HIS A 744HIS A 730ALA A 717 | CSO A 845 ( 4.1A) ZN A1870 ( 1.7A) ZN A1870 ( 3.3A) ZN A1870 ( 3.2A)None | 1.21A | 3r2jC-3zdrA:2.2 | 3r2jC-3zdrA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a5a | NUCLEOSIDE-TRIPHOSPHATASE 1 (Toxoplasmagondii) |
PF01150(GDA1_CD39) | 5 | ASP A 96LEU A 606ASP A 98HIS A 246ALA A 83 | None | 1.41A | 3r2jC-4a5aA:undetectable | 3r2jC-4a5aA:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fr2 | 1,3-PROPANEDIOLDEHYDROGENASE (Oenococcus oeni) |
PF00465(Fe-ADH) | 5 | LEU A 263ASP A 198HIS A 281HIS A 267ALA A 254 | None NI A 501 (-2.7A) NI A 501 (-3.6A) NI A 501 (-3.4A)None | 1.20A | 3r2jC-4fr2A:3.8 | 3r2jC-4fr2A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lfy | DIHYDROOROTASE (Burkholderiacenocepacia) |
PF01979(Amidohydro_1) | 5 | ASP A 268HIS A 31HIS A 33ALA A 284CYH A 239 | ZN A 401 (-2.7A) ZN A 401 (-3.3A) ZN A 401 (-3.3A)NoneNone | 1.09A | 3r2jC-4lfyA:undetectable | 3r2jC-4lfyA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mhp | GLUTAMINYL CYCLASE,PUTATIVE (Ixodesscapularis) |
PF04389(Peptidase_M28) | 5 | ASP A 326PHE A 139LEU A 132ASP A 144HIS A 128 | None | 1.27A | 3r2jC-4mhpA:undetectable | 3r2jC-4mhpA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mrq | PHOSPHOMANNOMUTASE/PHOSPHOGLUCOMUTASE (Pseudomonasaeruginosa) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | ASP A 244ASP A 246HIS A 329ALA A 184PHE A 241 | ZN A 501 ( 2.5A) ZN A 501 ( 2.3A)TLA A 502 (-4.0A)NoneNone | 1.40A | 3r2jC-4mrqA:undetectable | 3r2jC-4mrqA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qbj | GLYCYLPEPTIDEN-TETRADECANOYLTRANSFERASE (Aspergillusfumigatus) |
PF01233(NMT)PF02799(NMT_C) | 5 | PHE A 370LEU A 320HIS A 439TYR A 395ALA A 356 | None | 1.30A | 3r2jC-4qbjA:undetectable | 3r2jC-4qbjA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rp8 | ASCORBATE-SPECIFICPERMEASE IICCOMPONENT ULAA (Escherichiacoli) |
PF03611(EIIC-GAT) | 5 | PHE A 52LEU A 23HIS A 135ALA A 317CYH A 315 | NoneNoneASC A 501 (-4.1A)NoneASC A 501 ( 4.5A) | 1.33A | 3r2jC-4rp8A:undetectable | 3r2jC-4rp8A:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cgz | 4-OXALMESACONATEHYDRATASE (Pseudomonasputida) |
PF02585(PIG-L) | 5 | PHE A 161HIS A 127HIS A 117ALA A 22PHE A 18 | None ZN A 301 (-3.4A)NoneNoneNone | 1.29A | 3r2jC-5cgzA:3.5 | 3r2jC-5cgzA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e9g | ISOCITRATE LYASE (Magnaportheoryzae) |
PF00463(ICL) | 5 | ASP A 177LEU A 191ASP A 179HIS A 182ALA A 176 | MG A 603 ( 2.7A)None MG A 603 ( 4.9A)NoneNone | 1.29A | 3r2jC-5e9gA:undetectable | 3r2jC-5e9gA:17.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e9h | ISOCITRATE LYASE (Fusariumgraminearum) |
PF00463(ICL) | 5 | ASP A 177LEU A 191ASP A 179HIS A 182ALA A 176 | MN A 601 (-2.9A)NoneNoneNoneNone | 1.32A | 3r2jC-5e9hA:undetectable | 3r2jC-5e9hA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gle | ISCHORISMATE LYASE (Vibrioanguillarum) |
no annotation | 5 | ASP A 37PHE A 42TRP A 95LYS A 120TYR A 123 | None | 0.90A | 3r2jC-5gleA:19.2 | 3r2jC-5gleA:25.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vgm | DIHYDROOROTASE (Vibrio cholerae) |
PF01979(Amidohydro_1) | 5 | ASP A 246HIS A 13HIS A 15ALA A 262CYH A 217 | ZN A 402 (-2.7A) ZN A 402 (-3.3A) ZN A 402 (-3.3A)CSX A 261 ( 3.6A)None | 1.07A | 3r2jC-5vgmA:2.1 | 3r2jC-5vgmA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1u | CARBOXYLIC ESTERHYDROLASE (Culexquinquefasciatus) |
PF00135(COesterase) | 5 | PHE A 394LEU A 327HIS A 190HIS A 442PHE A 281 | MLI A 601 ( 4.1A)MLI A 601 (-4.6A)EPE A 600 ( 4.5A)EPE A 600 ( 4.0A)MLI A 601 (-3.7A) | 1.45A | 3r2jC-5w1uA:undetectable | 3r2jC-5w1uA:18.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wxv | ISOCHORISMATE LYASE (Vibrioanguillarum) |
no annotation | 5 | ASP A 39PHE A 44TRP A 97LYS A 122TYR A 125 | None | 0.80A | 3r2jC-5wxvA:19.5 | 3r2jC-5wxvA:15.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z2e | DIHYDRODIPICOLINATEREDUCTASE (Paenisporosarcinasp. TG-14) |
no annotation | 5 | PHE A 72LEU A 60ASP A 74HIS A 84ALA A 5 | None | 1.34A | 3r2jC-5z2eA:6.0 | 3r2jC-5z2eA:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6a8l | - (-) |
no annotation | 6 | ASP A 9LEU A 21ASP A 53HIS A 55LYS A 103CYH A 136 | NoneNone ZN A 200 (-2.7A) ZN A 200 (-3.2A)NoneNone | 1.13A | 3r2jC-6a8lA:23.1 | 3r2jC-6a8lA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6a8l | - (-) |
no annotation | 8 | ASP A 9PHE A 14LEU A 21ASP A 53HIS A 55HIS A 71LYS A 103TYR A 106 | NoneNoneNone ZN A 200 (-2.7A) ZN A 200 (-3.2A) ZN A 200 (-3.4A)NoneNone | 0.65A | 3r2jC-6a8lA:23.1 | 3r2jC-6a8lA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cty | DIHYDROOROTASE (Yersinia pestis) |
no annotation | 5 | ASP A 251HIS A 17HIS A 19ALA A 267CYH A 222 | ZN A 402 ( 2.8A) ZN A 402 (-3.4A) ZN A 402 ( 3.3A)CSX A 266 (-3.6A)None | 1.10A | 3r2jC-6ctyA:undetectable | 3r2jC-6ctyA:18.26 |