SIMILAR PATTERNS OF AMINO ACIDS FOR 3R24_A_SAMA302_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF07859
(Abhydrolase_3) 		3 TYR A  65
ASP A  89
ASP A  94
 None
 0.58A 3r24A-1evqA:
undetectable		 3r24A-1evqA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fr9 MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN

(Escherichia
coli) 		PF12804
(NTP_transf_3) 		3 TYR A  61
ASP A 101
ASP A  24
 None
 0.84A 3r24A-1fr9A:
undetectable		 3r24A-1fr9A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gw1 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		3 TYR A 184
ASP A 163
ASP A 150
 None
 0.61A 3r24A-1gw1A:
undetectable		 3r24A-1gw1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2i DNA REPAIR PROTEIN
RAD52 HOMOLOG

(Homo sapiens) 		PF04098
(Rad52_Rad22) 		3 TYR A 126
ASP A  97
ASP A  94
 None
 0.76A 3r24A-1h2iA:
undetectable		 3r24A-1h2iA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		3 TYR A 308
ASP A   2
ASP A 176
 None
 0.84A 3r24A-1j71A:
undetectable		 3r24A-1j71A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksr GELATION FACTOR

(Dictyostelium
discoideum) 		PF00630
(Filamin) 		3 TYR A  65
ASP A  84
ASP A  41
 None
 0.80A 3r24A-1ksrA:
undetectable		 3r24A-1ksrA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgj PEROXIDASE N

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		3 TYR A 262
ASP A 157
ASP A 272
 None
GSH  A1794 (-4.1A)
GSH  A1794 ( 4.2A)
 0.82A 3r24A-1qgjA:
undetectable		 3r24A-1qgjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwi OSMOTICALLY
INDUCIBLE PROTEIN

(Escherichia
coli) 		PF02566
(OsmC) 		3 TYR A 139
ASP A 110
ASP A 115
 None
 0.66A 3r24A-1qwiA:
undetectable		 3r24A-1qwiA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe4 FEMX

(Weissella
viridescens) 		PF02388
(FemAB) 		3 TYR A 126
ASP A  83
ASP A  88
 None
 0.82A 3r24A-1xe4A:
undetectable		 3r24A-1xe4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfi UNKNOWN PROTEIN

(Arabidopsis
thaliana) 		PF01937
(DUF89) 		3 TYR A  21
ASP A  99
ASP A 297
 None
 0.83A 3r24A-1xfiA:
3.0		 3r24A-1xfiA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y75 PHOSPHOLIPASE A2
ISOFORM 5
PHOSPHOLIPASE A2
ISOFORM 6

(Naja
sagittifera;
Naja
sagittifera) 		PF00068
(Phospholip_A2_1)
PF00068
(Phospholip_A2_1) 		3 TYR A 106
ASP B 114
ASP A  21
 None
 0.76A 3r24A-1y75A:
undetectable		 3r24A-1y75A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y75 PHOSPHOLIPASE A2
ISOFORM 5
PHOSPHOLIPASE A2
ISOFORM 6

(Naja
sagittifera;
Naja
sagittifera) 		PF00068
(Phospholip_A2_1)
PF00068
(Phospholip_A2_1) 		3 TYR B 106
ASP A 114
ASP B  21
 None
 0.75A 3r24A-1y75B:
undetectable		 3r24A-1y75B:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438

(Mycoplasma
genitalium) 		PF01420
(Methylase_S) 		3 TYR A 106
ASP A  79
ASP A 157
 None
 0.68A 3r24A-1ydxA:
undetectable		 3r24A-1ydxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb7 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 TYR A 289
ASP A 340
ASP A 345
 None
 0.63A 3r24A-1zb7A:
undetectable		 3r24A-1zb7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B)
PF01473
(CW_binding_1) 		3 TYR A 346
ASP A  39
ASP A  42
 None
 0.80A 3r24A-2bibA:
undetectable		 3r24A-2bibA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewo PUTATIVE AGMATINE
DEIMINASE

(Streptococcus
mutans) 		PF04371
(PAD_porph) 		3 TYR A 153
ASP A 112
ASP A  13
 None
 0.80A 3r24A-2ewoA:
undetectable		 3r24A-2ewoA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5x BUGD

(Bordetella
pertussis) 		PF03401
(TctC) 		3 TYR A 159
ASP A 175
ASP A 168
 None
 0.83A 3r24A-2f5xA:
undetectable		 3r24A-2f5xA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9n EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD) 		3 TYR A  48
ASP A  32
ASP A  35
 None
MLY  A  54 ( 3.5A)
None
 0.66A 3r24A-2g9nA:
3.4		 3r24A-2g9nA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE

(Leptospira
interrogans) 		PF01596
(Methyltransf_3) 		3 TYR A 164
ASP A 215
ASP A 211
 None
SO4  A1001 ( 4.8A)
None
 0.57A 3r24A-2hnkA:
9.6		 3r24A-2hnkA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5u DNAD DOMAIN PROTEIN

(Enterococcus
faecalis) 		PF07261
(DnaB_2) 		3 TYR A  58
ASP A  28
ASP A  21
 None
 0.79A 3r24A-2i5uA:
undetectable		 3r24A-2i5uA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iee PROBABLE ABC
TRANSPORTER
EXTRACELLULAR-BINDIN
G PROTEIN YCKB

(Bacillus
subtilis) 		PF00497
(SBP_bac_3) 		3 TYR A 157
ASP A 175
ASP A 168
 None
 0.81A 3r24A-2ieeA:
undetectable		 3r24A-2ieeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg7 ANTIQUITIN

(Acanthopagrus
schlegelii) 		PF00171
(Aldedh) 		3 TYR A  59
ASP A 239
ASP A 235
 None
 0.72A 3r24A-2jg7A:
3.4		 3r24A-2jg7A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 TYR A 288
ASP A 340
ASP A 345
 None
 0.72A 3r24A-2np0A:
undetectable		 3r24A-2np0A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii) 		PF01095
(Pectinesterase) 		3 TYR A 301
ASP A 199
ASP A 304
 None
 0.73A 3r24A-2ntbA:
undetectable		 3r24A-2ntbA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP

(Homo sapiens) 		PF01853
(MOZ_SAS) 		3 TYR A 194
ASP A 356
ASP A 273
 None
 0.84A 3r24A-2ou2A:
undetectable		 3r24A-2ou2A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7h HYPOTHETICAL PROTEIN

(Pectobacterium
atrosepticum) 		PF13489
(Methyltransf_23) 		3 TYR A 176
ASP A 117
ASP A 184
 None
 0.77A 3r24A-2p7hA:
8.6		 3r24A-2p7hA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm3 PREDICTED
METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF01861
(DUF43) 		3 TYR A 196
ASP A 151
ASP A 198
 None
 0.83A 3r24A-2qm3A:
7.8		 3r24A-2qm3A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		3 TYR A 250
ASP A 227
ASP A 222
 DSN  A 901 (-4.7A)
None
DSN  A 901 (-3.0A)
 0.84A 3r24A-2rcbA:
undetectable		 3r24A-2rcbA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		3 TYR A 882
ASP A 870
ASP A 836
 None
 0.83A 3r24A-2vcaA:
undetectable		 3r24A-2vcaA:
16.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		3 TYR A  47
ASP A  99
ASP A 130
 SAH  A1293 (-4.8A)
SAH  A1293 (-2.7A)
SAH  A1293 (-3.7A)
 0.09A 3r24A-2xyqA:
49.3		 3r24A-2xyqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zua NUCLEOSIDE
DIPHOSPHATE KINASE

(Haloarcula
quadrata) 		PF00334
(NDK) 		3 TYR A 108
ASP A  30
ASP A  23
 None
 0.79A 3r24A-2zuaA:
undetectable		 3r24A-2zuaA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		3 TYR A  62
ASP A  85
ASP A  90
 None
 0.49A 3r24A-3ailA:
2.2		 3r24A-3ailA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 TYR A 522
ASP A 444
ASP A 441
 None
 0.70A 3r24A-3cihA:
undetectable		 3r24A-3cihA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		3 TYR A 313
ASP A 271
ASP A 275
 None
 0.75A 3r24A-3da1A:
undetectable		 3r24A-3da1A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e18 OXIDOREDUCTASE

(Listeria
innocua) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 TYR A  52
ASP A  65
ASP A  61
 None
 0.70A 3r24A-3e18A:
undetectable		 3r24A-3e18A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 TYR A 396
ASP A 368
ASP A 411
 None
 0.77A 3r24A-3eh2A:
undetectable		 3r24A-3eh2A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frk QDTB

(Thermoanaerobacterium
thermosaccharolyticum) 		PF01041
(DegT_DnrJ_EryC1) 		3 TYR A 277
ASP A 113
ASP A 139
 None
 0.84A 3r24A-3frkA:
undetectable		 3r24A-3frkA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfv UNCHARACTERIZED ABC
TRANSPORTER
SOLUTE-BINDING
PROTEIN YCLQ

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		3 TYR A  68
ASP A  41
ASP A  46
 None
 0.85A 3r24A-3gfvA:
undetectable		 3r24A-3gfvA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gha DISULFIDE BOND
FORMATION PROTEIN D

(Bacillus
subtilis) 		PF13462
(Thioredoxin_4) 		3 TYR A 208
ASP A  92
ASP A  86
 None
 0.68A 3r24A-3ghaA:
undetectable		 3r24A-3ghaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TYR A 329
ASP A 344
ASP A 160
 None
 0.73A 3r24A-3i6tA:
undetectable		 3r24A-3i6tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0z PUTATIVE POLYKETIDE
CYCLASE

(Bacillus cereus) 		PF07366
(SnoaL) 		3 TYR A  63
ASP A  84
ASP A 147
 None
 0.72A 3r24A-3k0zA:
undetectable		 3r24A-3k0zA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng0 GLUTAMINE SYNTHETASE

(Synechocystis
sp. PCC 6803) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		3 TYR A 372
ASP A 229
ASP A 236
 None
 0.81A 3r24A-3ng0A:
undetectable		 3r24A-3ng0A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnm CURA

(Lyngbya
majuscula) 		PF05721
(PhyH) 		3 TYR A 150
ASP A 218
ASP A 212
 None
 0.61A 3r24A-3nnmA:
undetectable		 3r24A-3nnmA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwa ENVELOPE
GLYCOPROTEIN B

(Human
alphaherpesvirus
1) 		no annotation 3 TYR B 213
ASP B 167
ASP B 188
 None
 0.81A 3r24A-3nwaB:
undetectable		 3r24A-3nwaB:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 SEMAPHORIN-4D

(Homo sapiens) 		PF00047
(ig)
PF01403
(Sema)
PF01437
(PSI) 		3 TYR A 519
ASP A 437
ASP A 426
 None
 0.80A 3r24A-3ol2A:
undetectable		 3r24A-3ol2A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnn CONSERVED DOMAIN
PROTEIN

(Porphyromonas
gingivalis) 		no annotation 3 TYR A  68
ASP A 121
ASP A  34
 None
GOL  A 301 ( 2.8A)
None
 0.85A 3r24A-3pnnA:
undetectable		 3r24A-3pnnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxn KINESIN-LIKE PROTEIN
NOD

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		3 TYR A  64
ASP A  73
ASP A 119
 None
 0.58A 3r24A-3pxnA:
undetectable		 3r24A-3pxnA:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r24 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		3 TYR A  47
ASP A  99
ASP A 130
 SAM  A 302 (-4.5A)
SAM  A 302 (-2.6A)
SAM  A 302 (-3.6A)
 0.00A 3r24A-3r24A:
54.4		 3r24A-3r24A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sng NUCLEASE

(Solanum
lycopersicum) 		PF02265
(S1-P1_nuclease) 		3 TYR A  98
ASP A 104
ASP A 110
 BTB  A 603 ( 4.8A)
None
None
 0.69A 3r24A-3sngA:
undetectable		 3r24A-3sngA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 TYR A 525
ASP A 393
ASP A 399
 None
 0.75A 3r24A-3to3A:
undetectable		 3r24A-3to3A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr6 O-METHYLTRANSFERASE

(Coxiella
burnetii) 		PF01596
(Methyltransf_3) 		3 TYR A 154
ASP A 205
ASP A 201
 None
 0.71A 3r24A-3tr6A:
8.9		 3r24A-3tr6A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw0 PECTINESTERASE

(Yersinia
enterocolitica) 		PF01095
(Pectinesterase) 		3 TYR A 298
ASP A 199
ASP A 301
 None
 0.71A 3r24A-3uw0A:
undetectable		 3r24A-3uw0A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9w MONOOXYGENASE

(Stenotrophomonas
maltophilia) 		PF13738
(Pyr_redox_3) 		3 TYR A  72
ASP A 202
ASP A 204
 None
 0.85A 3r24A-4a9wA:
undetectable		 3r24A-4a9wA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF04054
(Not1) 		3 TYR A1829
ASP A1931
ASP A1885
 None
CA  A3080 (-3.6A)
None
 0.55A 3r24A-4by6A:
undetectable		 3r24A-4by6A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN

(Pyrococcus sp.
ST04) 		no annotation 3 TYR A 538
ASP A 562
ASP A 566
 None
 0.81A 3r24A-4cmrA:
undetectable		 3r24A-4cmrA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		3 TYR A 748
ASP A 576
ASP A 582
 None
 0.83A 3r24A-4cvuA:
undetectable		 3r24A-4cvuA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3s PUTATIVE PERIPLASMIC
BINDING PROTEIN

(Salmonella
enterica) 		PF00497
(SBP_bac_3) 		3 TYR A 150
ASP A 166
ASP A 159
 None
 0.82A 3r24A-4f3sA:
undetectable		 3r24A-4f3sA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 215
ASP A 243
ASP A 238
 None
 0.82A 3r24A-4fg8A:
undetectable		 3r24A-4fg8A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gba DCN1-LIKE PROTEIN 3

(Homo sapiens) 		PF03556
(Cullin_binding) 		3 TYR A  98
ASP A 160
ASP A 117
 None
 0.57A 3r24A-4gbaA:
undetectable		 3r24A-4gbaA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz8 SEMAPHORIN-3A

(Mus musculus) 		PF01403
(Sema) 		3 TYR A 534
ASP A 447
ASP A 437
 None
 0.73A 3r24A-4gz8A:
undetectable		 3r24A-4gz8A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl4 TBC1 DOMAIN FAMILY
MEMBER 20

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		3 TYR A 142
ASP A 148
ASP A 102
 None
 0.85A 3r24A-4hl4A:
undetectable		 3r24A-4hl4A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikh GLUTATHIONE
S-TRANSFERASE

(Pseudomonas
protegens) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 TYR A  96
ASP A  82
ASP A  76
 None
 0.83A 3r24A-4ikhA:
undetectable		 3r24A-4ikhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15892
(BNR_4) 		3 TYR A 297
ASP A 373
ASP A 349
 None
 0.82A 3r24A-4irtA:
undetectable		 3r24A-4irtA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		3 TYR A  91
ASP A  64
ASP A  69
 None
 0.71A 3r24A-4jccA:
undetectable		 3r24A-4jccA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		3 TYR A 252
ASP A 229
ASP A 224
 None
GOL  A 301 (-3.1A)
None
 0.80A 3r24A-4kcdA:
undetectable		 3r24A-4kcdA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3a INTERNALIN K

(Listeria
monocytogenes) 		no annotation 3 TYR A 371
ASP A 366
ASP A 385
 None
 0.74A 3r24A-4l3aA:
undetectable		 3r24A-4l3aA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3a INTERNALIN K

(Listeria
monocytogenes) 		no annotation 3 TYR A 449
ASP A 444
ASP A 463
 None
 0.83A 3r24A-4l3aA:
undetectable		 3r24A-4l3aA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyy HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Shewanella
pealeana) 		PF00156
(Pribosyltran) 		3 TYR A 155
ASP A  19
ASP A  50
 None
 0.52A 3r24A-4lyyA:
undetectable		 3r24A-4lyyA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzv EPITHELIAL CELL
ADHESION MOLECULE

(Homo sapiens) 		PF00086
(Thyroglobulin_1) 		3 TYR A 174
ASP A 232
ASP A 219
 DMU  A 301 (-4.7A)
DMU  A 301 (-3.5A)
None
 0.67A 3r24A-4mzvA:
undetectable		 3r24A-4mzvA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhz PUTATIVE GLUTATHIONE
S-TRANSFERASE ENZYME
WITH
THIOREDOXIN-LIKE
DOMAIN

(Bradyrhizobium
sp. BTAi1) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 TYR A  96
ASP A  82
ASP A  76
 None
 0.85A 3r24A-4nhzA:
undetectable		 3r24A-4nhzA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		3 TYR A 486
ASP A 569
ASP A 659
 None
 0.72A 3r24A-4o5pA:
undetectable		 3r24A-4o5pA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p08 COCAINE ESTERASE

(Rhodococcus sp.
MB1) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		3 TYR A 430
ASP A 425
ASP A 389
 None
 0.69A 3r24A-4p08A:
undetectable		 3r24A-4p08A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae) 		PF07859
(Abhydrolase_3) 		3 TYR A  63
ASP A  86
ASP A  91
 None
 0.63A 3r24A-4p9nA:
undetectable		 3r24A-4p9nA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py6 BROMODOMAIN PROTEIN,
PUTATIVE

(Plasmodium
falciparum) 		PF00439
(Bromodomain) 		3 TYR A1257
ASP A1244
ASP A1266
 None
 0.78A 3r24A-4py6A:
undetectable		 3r24A-4py6A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqb HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Staphylococcus
aureus) 		PF00156
(Pribosyltran) 		3 TYR A 148
ASP A  99
ASP A  35
 None
 0.79A 3r24A-4rqbA:
2.7		 3r24A-4rqbA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		3 TYR A 412
ASP A 288
ASP A 293
 None
 0.63A 3r24A-4wgkA:
undetectable		 3r24A-4wgkA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whi BETA-LACTAMASE

(Mycobacterium
tuberculosis) 		PF11954
(DUF3471) 		3 TYR A 451
ASP A 489
ASP A 491
 None
 0.85A 3r24A-4whiA:
undetectable		 3r24A-4whiA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdy KETOL-ACID
REDUCTOISOMERASE

(uncultured
archaeon
GZfos26G2) 		PF01450
(IlvC)
PF07991
(IlvN) 		3 TYR A  24
ASP A  37
ASP A  64
 None
None
GOL  A 405 (-3.7A)
 0.76A 3r24A-4xdyA:
2.7		 3r24A-4xdyA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		3 TYR A  25
ASP A  38
ASP A  60
 None
 0.61A 3r24A-4xehA:
2.7		 3r24A-4xehA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		3 TYR A  20
ASP A  43
ASP A 242
 None
 0.53A 3r24A-4xjxA:
undetectable		 3r24A-4xjxA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		3 TYR A  68
ASP A  93
ASP A  98
 None
 0.56A 3r24A-4ypvA:
undetectable		 3r24A-4ypvA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		3 TYR A 165
ASP A 142
ASP A 134
 None
 0.75A 3r24A-5a2rA:
undetectable		 3r24A-5a2rA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT

(Corynebacterium
glutamicum) 		PF01497
(Peripla_BP_2) 		3 TYR A 105
ASP A  84
ASP A 159
 None
 0.81A 3r24A-5az3A:
2.4		 3r24A-5az3A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		3 TYR A  25
ASP A  38
ASP A  60
 None
 0.65A 3r24A-5e4rA:
undetectable		 3r24A-5e4rA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fis EXD1

(Bombyx mori) 		PF01612
(DNA_pol_A_exo1) 		3 TYR B 224
ASP B 194
ASP B 199
 None
 0.84A 3r24A-5fisB:
undetectable		 3r24A-5fisB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis) 		PF14592
(Chondroitinas_B) 		3 TYR A 428
ASP A  83
ASP A 113
 None
 0.83A 3r24A-5gkqA:
undetectable		 3r24A-5gkqA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ito NOPALINE-BINDING
PERIPLASMIC PROTEIN

(Agrobacterium
fabrum) 		PF00497
(SBP_bac_3) 		3 TYR A 186
ASP A 202
ASP A 195
 None
 0.82A 3r24A-5itoA:
undetectable		 3r24A-5itoA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr8 E3 UBIQUITIN-PROTEIN
LIGASE TRIM33

(Homo sapiens) 		no annotation 3 TYR A1018
ASP A1002
ASP A1027
 None
 0.77A 3r24A-5mr8A:
undetectable		 3r24A-5mr8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mul NEURAMINIDASE

(Bacteroides
thetaiotaomicron) 		PF15892
(BNR_4) 		3 TYR A 297
ASP A 373
ASP A 349
 None
 0.81A 3r24A-5mulA:
undetectable		 3r24A-5mulA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvh BACCELL_00856

(Bacteroides
cellulosilyticus) 		PF15892
(BNR_4) 		3 TYR A 297
ASP A 373
ASP A 349
 None
 0.84A 3r24A-5mvhA:
undetectable		 3r24A-5mvhA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A

(Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9) 		3 TYR A 486
ASP A 475
ASP A 424
 None
 0.77A 3r24A-5odrA:
2.7		 3r24A-5odrA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4y SUSC HOMOLOG

(Bacteroides
thetaiotaomicron) 		no annotation 3 TYR D 461
ASP D 532
ASP D 419
 None
 0.76A 3r24A-5t4yD:
undetectable		 3r24A-5t4yD:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thw DEACYLASE

(Burkholderia
multivorans) 		PF01546
(Peptidase_M20) 		3 TYR A 229
ASP A 305
ASP A 312
 None
 0.76A 3r24A-5thwA:
undetectable		 3r24A-5thwA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twx BROMODOMAIN-CONTAINI
NG PROTEIN 9

(Homo sapiens) 		PF00439
(Bromodomain) 		3 TYR A 195
ASP A 182
ASP A 204
 None
 0.83A 3r24A-5twxA:
undetectable		 3r24A-5twxA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7g CREB-BINDING PROTEIN

(Mus musculus) 		PF00439
(Bromodomain)
PF00569
(ZZ)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		3 TYR A1148
ASP A1135
ASP A1157
 None
 0.85A 3r24A-5u7gA:
undetectable		 3r24A-5u7gA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v84 CAT EYE SYNDROME
CRITICAL REGION
PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		3 TYR A 493
ASP A 480
ASP A 502
 None
 0.85A 3r24A-5v84A:
undetectable		 3r24A-5v84A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 3 TYR A1300
ASP A1023
ASP A1330
 None
 0.81A 3r24A-5wblA:
undetectable		 3r24A-5wblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2

(Leptotrichia
shahii) 		no annotation 3 TYR A1180
ASP A1167
ASP A1328
 None
 0.81A 3r24A-5wtkA:
undetectable		 3r24A-5wtkA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yv5 ATPASE RIL

(Pyrococcus
furiosus) 		no annotation 3 TYR A 587
ASP A 513
ASP A 518
 None
 0.71A 3r24A-5yv5A:
undetectable		 3r24A-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqj KETOL-ACID
REDUCTOISOMERASE
(NADP(+))

(Staphylococcus
aureus) 		no annotation 3 TYR A  25
ASP A  38
ASP A  59
 GOL  A 405 ( 4.9A)
None
None
 0.72A 3r24A-6aqjA:
undetectable		 3r24A-6aqjA:
23.12