SIMILAR PATTERNS OF AMINO ACIDS FOR 3R24_A_SAMA302_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8m HUMAN RHINOVIRUS 16
COAT PROTEIN

(Rhinovirus A) 		PF00073
(Rhv) 		5 ASN 2  61
SER 2 245
GLY 2  19
LEU 2  66
ASP 2  67
 None
 1.37A 3r24A-1c8m2:
undetectable		 3r24A-1c8m2:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		5 GLY A  59
GLY A  64
LEU A  84
ASP A  99
MET A 125
 SAM  A 301 (-3.6A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.3A)
 0.98A 3r24A-1eizA:
14.9		 3r24A-1eizA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		5 GLY A  59
LEU A  84
ASP A  99
MET A 125
LYS A 164
 SAM  A 301 (-3.6A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.3A)
SAM  A 301 ( 3.9A)
 0.81A 3r24A-1eizA:
14.9		 3r24A-1eizA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1esc ESTERASE

(Streptomyces
scabiei) 		PF13472
(Lipase_GDSL_2) 		5 ASN A 106
GLY A  12
SER A  14
GLY A 104
ASN A  40
 None
 1.32A 3r24A-1escA:
2.7		 3r24A-1escA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 ASN A 223
GLY A 217
SER A 220
LEU A 241
ASP A 260
 SAM  A1699 (-4.1A)
SAM  A1699 (-3.6A)
None
SAM  A1699 (-4.2A)
SAM  A1699 (-3.8A)
 1.49A 3r24A-1fpqA:
8.0		 3r24A-1fpqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ivh ISOVALERYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 SER A 101
GLY A  94
LEU A 253
ASN A 106
ASP A 252
 None
None
None
None
COS  A 400 (-3.6A)
 1.40A 3r24A-1ivhA:
undetectable		 3r24A-1ivhA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp2 ARGININOSUCCINATE
SYNTHETASE

(Escherichia
coli) 		PF00764
(Arginosuc_synth) 		5 GLY A 221
PRO A  47
ASN A 217
ASP A 226
PHE A 224
 None
 1.30A 3r24A-1kp2A:
2.1		 3r24A-1kp2A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6j MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00040
(fn2)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 GLY A 339
PRO A  32
GLY A  33
ASP A 390
MET A 338
 None
 1.46A 3r24A-1l6jA:
undetectable		 3r24A-1l6jA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 PRO A1689
GLY A1688
ASN A1638
MET A1648
PHE A1630
 None
 1.23A 3r24A-1larA:
undetectable		 3r24A-1larA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV

(Griffonia
simplicifolia) 		PF00139
(Lectin_legB) 		5 GLY A 110
SER A 101
GLY A  26
ASP A 149
PHE A 108
 None
NAG  A 256 (-2.7A)
FUC  A 262 (-3.4A)
None
FUC  A 252 ( 4.6A)
 1.30A 3r24A-1ledA:
undetectable		 3r24A-1ledA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mda METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		5 GLY H 236
PRO H 222
GLY H 223
LEU H 234
MET H 245
 None
 1.49A 3r24A-1mdaH:
undetectable		 3r24A-1mdaH:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og0 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Saccharomyces
cerevisiae) 		PF00793
(DAHP_synth_1) 		5 GLY A 156
PRO A  75
GLY A  74
LEU A 171
PHE A 196
 None
 1.45A 3r24A-1og0A:
undetectable		 3r24A-1og0A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1onk GALACTOSE SPECIFIC
LECTIN I B CHAIN

(Viscum album) 		PF00652
(Ricin_B_lectin) 		5 ASN B  18
GLY B 131
SER B 181
GLY B  19
LEU B 228
 None
None
None
None
NAG  B5002 ( 4.7A)
 1.27A 3r24A-1onkB:
undetectable		 3r24A-1onkB:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrr SULFOLIPID
BIOSYNTHESIS (SQD1)
PROTEIN

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		5 ASN A 120
GLY A 123
CYH A 197
PHE A 288
LYS A 142
 None
 1.48A 3r24A-1qrrA:
4.9		 3r24A-1qrrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE

(Mytilus edulis) 		PF13714
(PEP_mutase) 		5 GLY A  45
GLY A  42
LEU A  48
ASN A 239
ASP A  58
 None
 1.44A 3r24A-1s2tA:
undetectable		 3r24A-1s2tA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaq CYTOSINE DEAMINASE

(Saccharomyces
cerevisiae) 		PF00383
(dCMP_cyt_deam_1) 		5 ASN A  51
GLY A  35
SER A  66
GLY A  25
LEU A  37
 DUC  A 300 (-3.9A)
None
None
None
None
 1.17A 3r24A-1uaqA:
undetectable		 3r24A-1uaqA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		5 ASN A 211
SER A 213
GLY A 210
LEU A 171
PHE A 234
 CA  A2003 (-3.2A)
None
None
None
None
 1.12A 3r24A-1ulvA:
undetectable		 3r24A-1ulvA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb3 THREONINE SYNTHASE

(Escherichia
coli) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		5 ASN A 366
GLY A 371
PRO A 367
GLY A 368
CYH A  95
 None
 1.46A 3r24A-1vb3A:
undetectable		 3r24A-1vb3A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		5 GLY A 202
SER A 210
GLY A 259
LEU A 193
ASP A 192
 None
 1.43A 3r24A-1vf8A:
undetectable		 3r24A-1vf8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 GLY A 358
SER A 144
GLY A 753
ASN A 350
PHE A 305
 None
None
None
None
GAL  A9011 (-4.9A)
 1.41A 3r24A-1xc6A:
undetectable		 3r24A-1xc6A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 ASN A 468
GLY A 291
GLY A 447
LEU A 262
PHE A 419
 None
None
None
None
NAP  A1518 (-3.7A)
 1.40A 3r24A-2ehqA:
2.1		 3r24A-2ehqA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hes YDR267CP

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 GLY X 217
SER X 221
GLY X 198
LEU X 245
CYH X 215
 None
CA  X 400 (-2.4A)
None
None
None
 1.46A 3r24A-2hesX:
undetectable		 3r24A-2hesX:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ASN A 209
GLY A 323
GLY A 208
LEU A  81
MET A 324
 None
 1.50A 3r24A-2j2mA:
undetectable		 3r24A-2j2mA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2

(Homo sapiens) 		PF01728
(FtsJ) 		5 GLY A  30
LEU A  63
ASP A  79
MET A 105
LYS A 144
 SAM  A 201 (-3.5A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.5A)
 0.66A 3r24A-2nyuA:
12.9		 3r24A-2nyuA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pne 6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN

(Hypogastrura
harveyi) 		no annotation 5 ASN A  40
GLY A  45
PRO A  41
GLY A  42
ASP A  75
 None
 1.43A 3r24A-2pneA:
undetectable		 3r24A-2pneA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q42 PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 2

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 ASN A  63
GLY A  76
PRO A  85
GLY A  86
ASP A  93
 None
 1.13A 3r24A-2q42A:
undetectable		 3r24A-2q42A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ru4 ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct) 		PF00514
(Arm) 		5 GLY A  73
SER A  26
GLY A 115
LEU A  29
ASP A  31
 None
 1.40A 3r24A-2ru4A:
undetectable		 3r24A-2ru4A:
16.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		12 ASN A  43
GLY A  71
SER A  74
PRO A  80
GLY A  81
LEU A 100
ASN A 101
ASP A 114
CYH A 115
MET A 131
PHE A 149
LYS A 170
 SAH  A1293 (-3.8A)
SAH  A1293 (-3.8A)
SAH  A1293 (-4.1A)
SAH  A1293 (-3.8A)
SAH  A1293 (-3.6A)
SAH  A1293 (-4.3A)
SAH  A1293 ( 4.7A)
SAH  A1293 (-3.7A)
SAH  A1293 (-3.7A)
SAH  A1293 (-3.8A)
SAH  A1293 (-4.6A)
None
 0.43A 3r24A-2xyqA:
49.3		 3r24A-2xyqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrr AMINOTRANSFERASE,
CLASS V

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		5 SER A  62
GLY A 183
LEU A 215
ASP A 216
PHE A 207
 PLP  A 500 (-2.7A)
None
None
None
None
 1.28A 3r24A-2yrrA:
2.5		 3r24A-2yrrA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		5 GLY A 166
SER A  50
GLY A 256
LEU A  88
PHE A 170
 None
 1.42A 3r24A-3agrA:
undetectable		 3r24A-3agrA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 ASN A 374
GLY A 142
GLY A 373
LEU A 147
ASP A 148
 None
 1.46A 3r24A-3aqiA:
2.4		 3r24A-3aqiA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b98 PROSTAGLANDIN I2
SYNTHASE

(Danio rerio) 		PF00067
(p450) 		5 ASN A 277
PRO A 280
GLY A 279
LEU A 227
PHE A 180
 HEM  A 600 (-4.1A)
None
None
None
None
 1.49A 3r24A-3b98A:
undetectable		 3r24A-3b98A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bog 6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN

(Hypogastrura
harveyi) 		no annotation 5 ASN A  40
GLY A  45
PRO A  41
GLY A  42
ASP A  75
 None
 1.38A 3r24A-3bogA:
undetectable		 3r24A-3bogA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE

(Methanosarcina
mazei) 		PF01933
(UPF0052) 		5 PRO A 237
GLY A 240
ASP A 268
MET A 246
PHE A 272
 None
 1.44A 3r24A-3cgwA:
undetectable		 3r24A-3cgwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE

(Corynebacterium
diphtheriae) 		PF12897
(Aminotran_MocR) 		5 SER A 349
PRO A 136
GLY A 137
LEU A  34
ASP A  33
 None
 1.45A 3r24A-3d6kA:
2.6		 3r24A-3d6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 GLY A 214
SER A 587
GLY A 211
LEU A 507
PHE A 490
 None
 1.49A 3r24A-3ddrA:
undetectable		 3r24A-3ddrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 GLY A 214
SER A 587
GLY A 224
LEU A 507
PHE A 490
 None
 1.42A 3r24A-3ddrA:
undetectable		 3r24A-3ddrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5z PUTATIVE
GLUCONOLACTONASE

(Deinococcus
radiodurans) 		PF08450
(SGL) 		5 GLY A 143
SER A 116
GLY A 146
ASN A  72
ASP A  46
 None
None
None
MG  A 297 ( 4.4A)
None
 1.34A 3r24A-3e5zA:
undetectable		 3r24A-3e5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		5 ASN A1170
GLY A1111
PRO A1115
LEU A1106
ASN A1104
 None
 1.40A 3r24A-3egwA:
undetectable		 3r24A-3egwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy4 6-4 PHOTOLYASE

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 ASN A 153
GLY A 311
GLY A 155
ASP A 114
PHE A 315
 None
 1.39A 3r24A-3fy4A:
undetectable		 3r24A-3fy4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h14 AMINOTRANSFERASE,
CLASSES I AND II

(Ruegeria
pomeroyi) 		PF00155
(Aminotran_1_2) 		5 GLY A 205
GLY A 312
LEU A 281
ASN A 284
ASP A 278
 None
None
None
None
GOL  A 501 (-3.0A)
 1.17A 3r24A-3h14A:
2.0		 3r24A-3h14A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lso PUTATIVE MEMBRANE
ANCHORED PROTEIN

(Corynebacterium
diphtheriae) 		PF16640
(Big_3_5) 		5 ASN B 410
GLY B 452
GLY B 387
ASP B 315
MET B 451
 None
 1.40A 3r24A-3lsoB:
undetectable		 3r24A-3lsoB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 GLY A 357
SER A 144
GLY A 755
ASN A 349
PHE A 304
 None
None
None
None
GAL  A1024 ( 4.8A)
 1.39A 3r24A-3ogrA:
undetectable		 3r24A-3ogrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pei CYTOSOL
AMINOPEPTIDASE

(Francisella
tularensis) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 ASN A 256
GLY A 335
GLY A 257
ASP A 341
CYH A 340
 None
CL  A 496 ( 3.9A)
None
None
None
 1.37A 3r24A-3peiA:
undetectable		 3r24A-3peiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppl ASPARTATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF12897
(Aminotran_MocR) 		5 SER A 353
PRO A 140
GLY A 141
LEU A  37
ASP A  36
 None
 1.48A 3r24A-3pplA:
2.5		 3r24A-3pplA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 ASN A 159
GLY A 260
SER A 124
GLY A 164
LEU A 262
 None
PG4  A 413 (-3.5A)
None
None
None
 1.18A 3r24A-3qt4A:
undetectable		 3r24A-3qt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r24 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		12 ASN A  43
GLY A  71
SER A  74
PRO A  80
GLY A  81
LEU A 100
ASN A 101
ASP A 114
CYH A 115
MET A 131
PHE A 149
LYS A 170
 SAM  A 302 (-3.5A)
SAM  A 302 (-3.7A)
SAM  A 302 ( 4.4A)
SAM  A 302 (-3.8A)
SAM  A 302 (-3.4A)
SAM  A 302 (-4.4A)
SAM  A 302 (-4.0A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.7A)
SAM  A 302 ( 4.8A)
SAM  A 302 (-3.1A)
 0.07A 3r24A-3r24A:
54.4		 3r24A-3r24A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u37 ACETYL-XYLAN
ESTERASE EST2A

(Butyrivibrio
proteoclasticus) 		PF13472
(Lipase_GDSL_2) 		5 ASN A 245
GLY A 140
SER A 142
GLY A 243
LEU A 183
 ACY  A 401 (-2.9A)
None
ACY  A 401 (-2.8A)
None
None
 1.46A 3r24A-3u37A:
undetectable		 3r24A-3u37A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 253
PRO A 259
GLY A 258
LEU A 273
MET A 275
 None
None
None
None
MG  A 500 ( 4.9A)
 1.33A 3r24A-3ugvA:
undetectable		 3r24A-3ugvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un1 PROBABLE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ASN A 154
SER A 128
GLY A 152
ASN A  79
PHE A  83
 None
 1.41A 3r24A-3un1A:
5.5		 3r24A-3un1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uuf LIP1, SECRETORY
LIPASE (FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		5 SER A 256
PRO A 251
GLY A 252
LEU A 259
ASP A 245
 None
None
NAG  A 501 ( 4.1A)
None
None
 1.40A 3r24A-3uufA:
undetectable		 3r24A-3uufA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		5 GLY A 289
SER A 282
GLY A  76
LEU A 291
ASP A 292
 None
None
None
None
BCT  A 435 (-4.6A)
 1.46A 3r24A-3v7pA:
undetectable		 3r24A-3v7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
coelicolor) 		PF08241
(Methyltransf_11) 		5 GLY A 110
SER A  82
GLY A  45
CYH A 106
MET A 112
 None
 1.33A 3r24A-3vc1A:
7.9		 3r24A-3vc1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqi ATG5

(Kluyveromyces
marxianus) 		PF04106
(APG5) 		5 SER A 261
PRO A  85
GLY A  87
LEU A 255
ASP A 250
 None
 1.47A 3r24A-3vqiA:
undetectable		 3r24A-3vqiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgk CELL DIVISION
PROTEIN FTSZ

(Staphylococcus
aureus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A 104
PRO A 115
GLY A 112
ASP A 187
PHE A 183
 GDP  A 400 ( 3.7A)
None
None
GDP  A 400 (-3.0A)
GDP  A 400 (-3.7A)
 1.49A 3r24A-3wgkA:
4.1		 3r24A-3wgkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Lactobacillus
acidophilus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 GLY A 325
SER A 497
PRO A 529
LEU A 285
ASP A 272
 None
None
MES  A1539 (-4.1A)
None
None
 1.36A 3r24A-4aieA:
undetectable		 3r24A-4aieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		5 ASN A 203
GLY A 159
SER A 154
GLY A 200
ASN A 125
 None
 1.31A 3r24A-4areA:
undetectable		 3r24A-4areA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 PRO A1756
GLY A1755
ASN A1705
MET A1715
PHE A1697
 None
 1.28A 3r24A-4bpcA:
undetectable		 3r24A-4bpcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehc PE-PGRS FAMILY
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 5 SER A 261
LEU A 143
ASN A 156
ASP A 145
PHE A 253
 EDO  A 309 ( 4.5A)
None
EDO  A 317 ( 3.3A)
None
None
 1.43A 3r24A-4ehcA:
undetectable		 3r24A-4ehcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		5 SER A 226
GLY A 256
LEU A  21
MET A 260
PHE A 461
 None
None
None
None
2OB  A 605 (-3.9A)
 1.43A 3r24A-4f2aA:
undetectable		 3r24A-4f2aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f8x ENDO-1,4-BETA-XYLANA
SE

(Penicillium
canescens) 		PF00331
(Glyco_hydro_10) 		5 ASN A 302
GLY A 304
LEU A  32
ASP A  28
PHE A  41
 None
 1.22A 3r24A-4f8xA:
undetectable		 3r24A-4f8xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1

(Homo sapiens) 		PF13181
(TPR_8)
PF13424
(TPR_12) 		5 ASN A 216
GLY A 180
ASN A 174
ASP A 142
CYH A 163
 None
 1.41A 3r24A-4houA:
undetectable		 3r24A-4houA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		5 GLY A 216
PRO A 224
GLY A 222
ASN A  26
ASP A  41
 None
None
NAD  A 601 (-3.7A)
None
None
 1.44A 3r24A-4i8qA:
undetectable		 3r24A-4i8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H 139
SER H 125
PRO H 212
LEU H 141
PHE H 166
 None
 1.28A 3r24A-4k3eH:
undetectable		 3r24A-4k3eH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdr 3-DEMETHYLUBIQUINONE
-9
3-METHYLTRANSFERASE

(Escherichia
coli) 		PF13489
(Methyltransf_23) 		5 GLY A  32
LEU A  70
ASN A  41
ASP A  62
CYH A  65
 None
None
None
SAH  A 301 ( 4.5A)
None
 1.36A 3r24A-4kdrA:
8.5		 3r24A-4kdrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7o IRON-BINDING PROTEIN

(Staphylococcus
epidermidis) 		PF01497
(Peripla_BP_2) 		5 GLY A 284
SER A 275
PRO A 277
GLY A 278
ASP A 290
 None
 1.42A 3r24A-4m7oA:
2.3		 3r24A-4m7oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		5 GLY A 451
GLY A 159
ASN A 449
ASP A 456
PHE A 453
 None
 1.45A 3r24A-4madA:
undetectable		 3r24A-4madA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00745
(GlutR_dimer)
PF01488
(Shikimate_DH)
PF05201
(GlutR_N) 		5 GLY A 227
SER A 233
GLY A 224
LEU A 152
ASN A 231
 None
 1.24A 3r24A-4n7rA:
4.7		 3r24A-4n7rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsp ENDONUCLEASE V

(Homo sapiens) 		PF04493
(Endonuclease_5) 		5 ASN A 128
GLY A 194
GLY A 152
LEU A 186
PHE A 183
 None
 1.39A 3r24A-4nspA:
undetectable		 3r24A-4nspA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntd THIOREDOXIN
REDUCTASE

(Streptomyces
clavuligerus) 		PF07992
(Pyr_redox_2) 		5 ASN A 275
GLY A  17
SER A 286
GLY A 118
ASN A  22
 FAD  A 402 ( 3.7A)
FAD  A 402 (-3.5A)
FAD  A 402 (-3.4A)
FAD  A 402 ( 3.7A)
None
 1.31A 3r24A-4ntdA:
undetectable		 3r24A-4ntdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o89 RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Pyrococcus
horikoshii) 		PF01137
(RTC)
PF05189
(RTC_insert) 		5 ASN A  41
GLY A  13
PRO A  42
GLY A  43
ASP A 286
 None
CIT  A 401 (-3.2A)
None
None
None
 1.09A 3r24A-4o89A:
undetectable		 3r24A-4o89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qan HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus) 		no annotation 5 GLY A 394
SER A 383
PRO A 387
LEU A 297
PHE A 304
 None
 1.41A 3r24A-4qanA:
undetectable		 3r24A-4qanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr6 DNA POLYMERASE III
SUBUNIT BETA

(Bacillus
subtilis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 GLY A  34
SER A  49
PRO A 126
LEU A  20
PHE A  84
 None
 1.48A 3r24A-4tr6A:
undetectable		 3r24A-4tr6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 5 GLY A1696
LEU A1720
ASP A1755
PHE A1782
LYS A1817
 None
 1.29A 3r24A-4uclA:
10.0		 3r24A-4uclA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1

(Mus musculus) 		PF01501
(Glyco_transf_8) 		5 GLY A 286
PRO A 280
GLY A 283
ASN A 288
ASP A 329
 None
 1.46A 3r24A-4wm0A:
undetectable		 3r24A-4wm0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Sus scrofa) 		PF00202
(Aminotran_3) 		5 GLY A 437
SER A 413
GLY A 440
LEU A  68
ASP A  67
 None
 1.39A 3r24A-4y0iA:
undetectable		 3r24A-4y0iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		5 ASN C 276
GLY C 312
GLY C 275
MET C 311
PHE C 346
 None
 1.41A 3r24A-4yfaC:
undetectable		 3r24A-4yfaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhg GH5

(Bacteroidetes
bacterium AC2a) 		PF00150
(Cellulase) 		5 GLY A 305
GLY A 258
LEU A 337
ASN A  27
PHE A 301
 None
 1.35A 3r24A-4yhgA:
undetectable		 3r24A-4yhgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yog 3C-LIKE PROTEINASE

(Tylonycteris
bat coronavirus
HKU4) 		PF05409
(Peptidase_C30) 		5 GLY A 177
SER A 179
GLY A 186
CYH A 148
PHE A 143
 None
None
None
4F5  A 405 (-3.1A)
None
 1.42A 3r24A-4yogA:
undetectable		 3r24A-4yogA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE

(Bacillus cereus) 		PF05547
(Peptidase_M6) 		5 GLY A 411
SER A 424
GLY A 659
ASN A 429
ASP A 389
 None
None
None
None
ZN  A1001 (-2.4A)
 1.12A 3r24A-4yu5A:
undetectable		 3r24A-4yu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		5 GLY C 270
PRO C 523
GLY C 502
LEU C 387
ASP C 380
 None
NFU  C 701 (-3.3A)
None
None
None
 1.40A 3r24A-5aa5C:
undetectable		 3r24A-5aa5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2) 		5 ASN A 413
GLY A 183
GLY A 459
LEU A 208
PHE A 201
 None
 1.44A 3r24A-5bxpA:
undetectable		 3r24A-5bxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF12897
(Aminotran_MocR) 		5 SER A 351
PRO A 137
GLY A 138
LEU A  34
ASP A  33
 None
None
CL  A 503 ( 3.8A)
None
None
 1.40A 3r24A-5c6uA:
undetectable		 3r24A-5c6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		5 ASN A 478
GLY A 514
GLY A 477
MET A 513
PHE A 548
 None
 1.47A 3r24A-5c9iA:
undetectable		 3r24A-5c9iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d86 PROBABLE SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNA

(Staphylococcus
aureus) 		PF00291
(PALP) 		5 GLY A 270
SER A 254
GLY A 228
LEU A 261
PHE A 268
 None
None
PLP  A1001 (-4.1A)
None
None
 1.30A 3r24A-5d86A:
undetectable		 3r24A-5d86A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d86 PROBABLE SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNA

(Staphylococcus
aureus) 		PF00291
(PALP) 		5 GLY A 270
SER A 275
GLY A 228
LEU A 261
PHE A 268
 None
None
PLP  A1001 (-4.1A)
None
None
 1.36A 3r24A-5d86A:
undetectable		 3r24A-5d86A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkp ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Neisseria
meningitidis) 		PF00574
(CLP_protease) 		5 GLY A  78
SER A  44
PRO A  39
GLY A  72
ASN A  46
 None
 1.47A 3r24A-5dkpA:
undetectable		 3r24A-5dkpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6j ENVELOPE
GLYCOPROTEIN GP120
OF HIV-1 CLADE C

(Human
immunodeficiency
virus 1) 		no annotation 5 ASN G 276
GLY G 235
MET G  95
PHE G  93
LYS G  97
 None
 1.50A 3r24A-5f6jG:
undetectable		 3r24A-5f6jG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jce CHITIN
ELICITOR-BINDING
PROTEIN

(Oryza sativa) 		PF01476
(LysM) 		5 ASN A  74
GLY A 246
GLY A  75
LEU A 237
ASP A 234
 None
 1.46A 3r24A-5jceA:
undetectable		 3r24A-5jceA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m89 SPLICEOSOME WD40 SC

(Chaetomium
thermophilum) 		no annotation 5 GLY A 453
SER A 467
PRO A 450
GLY A 426
ASP A 210
 None
 1.50A 3r24A-5m89A:
undetectable		 3r24A-5m89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olp PECTATE LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 SER A 133
PRO A  90
GLY A  89
LEU A 198
ASN A 131
 None
 1.36A 3r24A-5olpA:
undetectable		 3r24A-5olpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2o J30 CCH

(Thermobacillus
composti) 		no annotation 5 ASN A 354
GLY A 416
SER A 348
LEU A 421
PHE A 534
 None
 1.36A 3r24A-5u2oA:
undetectable		 3r24A-5u2oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT

(Oryctolagus
cuniculus) 		no annotation 5 GLY B 215
SER B 354
GLY B 202
LEU B 359
ASN B 356
 None
 1.48A 3r24A-5w7aB:
undetectable		 3r24A-5w7aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjc KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
pombe) 		no annotation 5 ASN A 193
PRO A 192
LEU A 296
ASN A 290
ASP A 310
 None
 1.46A 3r24A-5wjcA:
undetectable		 3r24A-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 GLY A 290
GLY A 296
LEU A 313
ASP A 338
CYH A 339
 SAH  A 703 (-4.0A)
None
SAH  A 703 (-4.1A)
SAH  A 703 (-3.3A)
SAH  A 703 (-3.5A)
 0.80A 3r24A-5wp4A:
8.9		 3r24A-5wp4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 5 GLY A 290
GLY A 296
LEU A 313
ASP A 338
CYH A 339
 SAH  A 501 (-3.8A)
None
SAH  A 501 (-3.9A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.5A)
 0.84A 3r24A-5wp5A:
8.2		 3r24A-5wp5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY

(uncultured
archaeon
MedDCM-OCT-S05-C57) 		no annotation 5 ASN A 131
PRO A 132
GLY A 116
ASN A 232
ASP A 279
 None
 0.97A 3r24A-5y1gA:
4.5		 3r24A-5y1gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN

(Homo sapiens) 		no annotation 5 GLY A 237
GLY A 286
ASN A 141
CYH A 211
PHE A 253
 None
 1.42A 3r24A-5yy8A:
undetectable		 3r24A-5yy8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 5 GLY A  41
GLY A 113
LEU A   7
ASN A 191
PHE A  71
 None
 1.14A 3r24A-5zb8A:
undetectable		 3r24A-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 5 GLY A1173
SER A1178
GLY A1279
CYH A1188
PHE A1170
 None
 1.22A 3r24A-6b3rA:
undetectable		 3r24A-6b3rA:
undetectable