SIMILAR PATTERNS OF AMINO ACIDS FOR 3R0L_D_ACTD127

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a2a PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		5 PHE A   5
ILE A   9
GLY A  30
CYH A  45
HIS A  48
 None
 0.56A 3r0lD-1a2aA:
24.0		 3r0lD-1a2aA:
79.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aok VIPOXIN COMPLEX

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		4 PHE B   5
ILE B   9
GLY B  30
HIS B  48
 ACT  B 134 (-4.6A)
None
ACT  B 134 (-3.7A)
ACT  B 134 (-3.6A)
 0.46A 3r0lD-1aokB:
20.6		 3r0lD-1aokB:
57.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bun BETA2-BUNGAROTOXIN

(Bungarus
multicinctus) 		PF00068
(Phospholip_A2_1) 		4 PHE A   5
ILE A   9
GLY A  30
HIS A  48
 None
None
NA  A 121 (-4.4A)
None
 0.71A 3r0lD-1bunA:
18.9		 3r0lD-1bunA:
42.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnv CONCANAVALIN B

(Canavalia
ensiformis) 		PF00704
(Glyco_hydro_18) 		4 PHE A  32
ILE A  30
GLY A 125
HIS A 127
 None
 1.14A 3r0lD-1cnvA:
undetectable		 3r0lD-1cnvA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		4 PHE M 175
ILE M  98
GLY M 117
HIS M 122
 None
 1.18A 3r0lD-1dwaM:
undetectable		 3r0lD-1dwaM:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eys PHOTOSYNTHETIC
REACTION CENTER

(Thermochromatium
tepidum) 		PF02276
(CytoC_RC) 		4 ILE C 217
GLY C 224
CYH C 228
HIS C 229
 HEM  C 612 (-4.2A)
None
HEM  C 611 (-1.7A)
HEM  C 611 (-3.6A)
 1.22A 3r0lD-1eysC:
undetectable		 3r0lD-1eysC:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 PHE B 607
ILE B 622
GLY B 539
HIS B 582
 None
 1.14A 3r0lD-1ffvB:
undetectable		 3r0lD-1ffvB:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhq PROTEIN KINASE SPK1

(Saccharomyces
cerevisiae) 		PF00498
(FHA) 		4 PHE A 692
ILE A 690
GLY A 604
CYH A 623
 None
 1.35A 3r0lD-1fhqA:
undetectable		 3r0lD-1fhqA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)

(Homo sapiens) 		PF00012
(HSP70) 		4 PHE A 245
ILE A 253
GLY A 290
HIS A 249
 None
 1.22A 3r0lD-1hjoA:
undetectable		 3r0lD-1hjoA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jer CUCUMBER
STELLACYANIN

(Cucumis sativus) 		PF02298
(Cu_bind_like) 		4 PHE A  31
ILE A 103
GLY A  28
HIS A   5
 None
 1.27A 3r0lD-1jerA:
undetectable		 3r0lD-1jerA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 PHE A 285
ILE A 248
GLY A 255
CYH A 687
 None
 1.31A 3r0lD-1jqoA:
2.1		 3r0lD-1jqoA:
7.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mh2 PHOSPHOLIPASE A2

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		4 PHE A   5
ILE A   9
GLY A  30
HIS A  48
 None
None
None
ACY  A 302 (-3.4A)
 0.59A 3r0lD-1mh2A:
18.9		 3r0lD-1mh2A:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk4 HYPOTHETICAL PROTEIN
YQJY

(Bacillus
subtilis) 		PF00583
(Acetyltransf_1) 		4 PHE A 152
ILE A 126
GLY A 123
HIS A 119
 None
 1.23A 3r0lD-1mk4A:
undetectable		 3r0lD-1mk4A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxj PROBABLE
S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF03737
(RraA-like) 		4 PHE A  26
ILE A  94
GLY A 153
CYH A  22
 None
None
GLV  A 741 ( 4.5A)
None
 1.33A 3r0lD-1nxjA:
undetectable		 3r0lD-1nxjA:
17.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p7o PHOSPHOLIPASE A2

(Micropechis
ikaheca) 		PF00068
(Phospholip_A2_1) 		4 PHE A   5
ILE A   9
GLY A  30
HIS A  48
 None
 0.58A 3r0lD-1p7oA:
19.1		 3r0lD-1p7oA:
38.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q6v PHOSPHOLIPASE A2
VRV-PL-VIIIA

(Daboia russelii) 		PF00068
(Phospholip_A2_1) 		4 PHE A   5
ILE A   9
GLY A  30
HIS A  48
 None
 0.65A 3r0lD-1q6vA:
21.9		 3r0lD-1q6vA:
58.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00117
(GATase) 		4 PHE B  94
ILE B  90
GLY B  75
HIS B 164
 None
 1.22A 3r0lD-1qdlB:
undetectable		 3r0lD-1qdlB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 PHE A 191
ILE A 187
CYH A 229
HIS A 232
 None
 1.14A 3r0lD-1szsA:
undetectable		 3r0lD-1szsA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3g X-LINKED
INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1

(Homo sapiens) 		PF01582
(TIR) 		4 PHE A 429
ILE A 510
GLY A 541
CYH A 544
 None
 1.26A 3r0lD-1t3gA:
undetectable		 3r0lD-1t3gA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnu GERANYLGERANYL
TRANSFERASE TYPE I
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		4 PHE B  20
ILE B 337
GLY B 325
HIS B  25
 None
 0.74A 3r0lD-1tnuB:
undetectable		 3r0lD-1tnuB:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrn PHOTOSYNTHETIC
REACTION CENTER
CYTOCHROME C SUBUNIT

(Blastochloris
viridis) 		PF02276
(CytoC_RC) 		4 ILE C  77
GLY C  86
CYH C  90
HIS C  91
 HEM  C 402 (-4.1A)
None
HEM  C 401 (-1.8A)
HEM  C 401 (-3.2A)
 1.24A 3r0lD-1vrnC:
undetectable		 3r0lD-1vrnC:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvh TENSIN

(Gallus gallus) 		PF08416
(PTB) 		4 PHE A1648
ILE A1729
GLY A1700
CYH A1678
 None
 1.29A 3r0lD-1wvhA:
undetectable		 3r0lD-1wvhA:
18.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zl7 HYPOTENSIVE
PHOSPHOLIPASE A2

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		4 PHE A   5
ILE A   9
GLY A  29
HIS A  47
 None
 0.62A 3r0lD-1zl7A:
21.2		 3r0lD-1zl7A:
54.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae6 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF00583
(Acetyltransf_1) 		4 PHE A 129
ILE A  84
GLY A  94
HIS A 133
 None
 1.19A 3r0lD-2ae6A:
undetectable		 3r0lD-2ae6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1n SPE31

(Pachyrhizus
erosus) 		PF00112
(Peptidase_C1) 		4 PHE A 218
ILE A 115
GLY A 112
HIS A  69
 None
 1.34A 3r0lD-2b1nA:
undetectable		 3r0lD-2b1nA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv7 GLYCOLIPID TRANSFER
PROTEIN

(Bos taurus) 		PF08718
(GLTP) 		4 PHE A 148
ILE A  45
GLY A 100
HIS A 140
 GM3  A1212 (-4.6A)
GM3  A1212 (-4.4A)
GM3  A1212 ( 3.7A)
GM3  A1212 (-3.6A)
 1.24A 3r0lD-2bv7A:
undetectable		 3r0lD-2bv7A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs3 PROTEIN C14ORF4

(Homo sapiens) 		PF00097
(zf-C3HC4) 		4 PHE A  41
ILE A  20
GLY A  64
HIS A  39
 None
ZN  A 200 ( 4.5A)
None
ZN  A 400 (-3.1A)
 1.39A 3r0lD-2cs3A:
undetectable		 3r0lD-2cs3A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE

(Oryza sativa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 PHE A 171
ILE A 155
GLY A 149
HIS A 187
 None
 1.16A 3r0lD-2cvoA:
undetectable		 3r0lD-2cvoA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg0 DRP35

(Staphylococcus
aureus) 		PF08450
(SGL) 		4 PHE A 101
ILE A 127
GLY A 147
HIS A  95
 None
 1.27A 3r0lD-2dg0A:
undetectable		 3r0lD-2dg0A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fck RIBOSOMAL-PROTEIN-SE
RINE
ACETYLTRANSFERASE,
PUTATIVE

(Vibrio cholerae) 		PF13302
(Acetyltransf_3) 		4 PHE A  73
ILE A  17
GLY A  82
CYH A  28
 None
None
None
GOL  A 401 (-2.9A)
 1.40A 3r0lD-2fckA:
undetectable		 3r0lD-2fckA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gxa REPLICATION PROTEIN
E1

(Deltapapillomavirus
4) 		PF00519
(PPV_E1_C) 		4 PHE A 311
GLY A 314
CYH A 361
HIS A 357
 None
 1.17A 3r0lD-2gxaA:
undetectable		 3r0lD-2gxaA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		4 PHE A 151
ILE A 147
GLY A 140
HIS A 152
 None
 1.36A 3r0lD-2hrzA:
undetectable		 3r0lD-2hrzA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isb FUMARASE

(Archaeoglobus
fulgidus) 		PF05683
(Fumerase_C) 		4 PHE A 163
ILE A 138
GLY A  80
CYH A  64
 None
 1.24A 3r0lD-2isbA:
undetectable		 3r0lD-2isbA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		4 PHE A 195
ILE A 118
GLY A 137
HIS A 142
 None
 1.26A 3r0lD-2jf7A:
undetectable		 3r0lD-2jf7A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0u STILBENECARBOXYLATE
SYNTHASE 2

(Marchantia
polymorpha) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 391
ILE A 293
GLY A 324
HIS A 321
 None
 1.31A 3r0lD-2p0uA:
undetectable		 3r0lD-2p0uA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B

(Bos taurus) 		PF00400
(WD40) 		4 PHE C   6
ILE C  25
GLY C 352
HIS C   4
 None
 1.29A 3r0lD-2p9nC:
undetectable		 3r0lD-2p9nC:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		4 PHE A 149
ILE A  75
GLY A  92
HIS A  97
 None
 1.10A 3r0lD-2pbgA:
undetectable		 3r0lD-2pbgA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		4 PHE A 353
ILE A 285
GLY A 313
HIS A 345
 EDO  A 478 (-4.7A)
None
None
EDO  A 478 (-4.7A)
 1.15A 3r0lD-2qneA:
undetectable		 3r0lD-2qneA:
13.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qog PHOSPHOLIPASE A2 CB2

(Crotalus
durissus) 		PF00068
(Phospholip_A2_1) 		4 PHE A   5
ILE A   9
GLY A  30
HIS A  48
 None
 0.68A 3r0lD-2qogA:
21.2		 3r0lD-2qogA:
96.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq9 RNASE 1

(Danio rerio) 		PF00074
(RnaseA) 		4 PHE A  82
ILE A 109
GLY A  65
HIS A  57
 None
 1.03A 3r0lD-2vq9A:
undetectable		 3r0lD-2vq9A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 PHE A 115
ILE A  76
GLY A 119
HIS A 117
 None
 1.38A 3r0lD-2wzsA:
undetectable		 3r0lD-2wzsA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 PHE A 563
ILE A 567
GLY A 623
HIS A 620
 None
 1.17A 3r0lD-2xvgA:
undetectable		 3r0lD-2xvgA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		4 PHE A 117
ILE A  19
GLY A  14
HIS A  42
 None
 1.39A 3r0lD-2yxlA:
undetectable		 3r0lD-2yxlA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zp2 KINASE A INHIBITOR

(Bacillus
subtilis) 		PF02682
(CT_C_D) 		4 PHE A 224
ILE A 104
GLY A 199
HIS A 134
 None
 1.37A 3r0lD-2zp2A:
undetectable		 3r0lD-2zp2A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b54 NUCLEOSIDE
DIPHOSPHATE KINASE

(Saccharomyces
cerevisiae) 		PF00334
(NDK) 		4 PHE A  29
ILE A  91
GLY A 120
CYH A 118
 None
None
PO4  A 154 ( 4.8A)
None
 1.30A 3r0lD-3b54A:
undetectable		 3r0lD-3b54A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 PHE B 110
ILE B 270
GLY B 108
HIS B 272
 None
 1.30A 3r0lD-3blxB:
undetectable		 3r0lD-3blxB:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c02 AQUAGLYCEROPORIN

(Plasmodium
falciparum) 		PF00230
(MIP) 		4 PHE A  83
ILE A  88
GLY A  76
HIS A  68
 None
None
None
GOL  A 665 ( 4.8A)
 1.25A 3r0lD-3c02A:
undetectable		 3r0lD-3c02A:
17.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dih PHOSPHOLIPASE A2
HOMOLOG, AMMODYTIN L

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		4 PHE A   5
ILE A   9
GLY A  29
HIS A  47
 None
 0.53A 3r0lD-3dihA:
21.8		 3r0lD-3dihA:
53.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebj POLYMERASE ACIDIC
PROTEIN

(Influenza A
virus) 		PF00603
(Flu_PA) 		4 PHE A 148
ILE A 171
GLY A 121
HIS A 146
 None
 1.33A 3r0lD-3ebjA:
undetectable		 3r0lD-3ebjA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA

(Methanocaldococcus
jannaschii) 		PF00282
(Pyridoxal_deC) 		4 ILE A  90
GLY A 247
CYH A 249
HIS A 244
 None
None
None
PLP  A 500 (-4.1A)
 1.23A 3r0lD-3f9tA:
undetectable		 3r0lD-3f9tA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		4 PHE A 131
ILE A  79
GLY A  96
HIS A  55
 None
 1.28A 3r0lD-3fmqA:
undetectable		 3r0lD-3fmqA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn5 SORTASE A

(Streptococcus
pyogenes) 		PF04203
(Sortase) 		4 PHE A 145
ILE A 211
CYH A 208
HIS A 143
 None
 1.04A 3r0lD-3fn5A:
undetectable		 3r0lD-3fn5A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium) 		PF12891
(Glyco_hydro_44) 		4 PHE A 113
ILE A 126
GLY A  74
HIS A  71
 None
 1.25A 3r0lD-3fw6A:
undetectable		 3r0lD-3fw6A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs9 PROTEIN GP18

(Listeria
monocytogenes) 		PF06605
(Prophage_tail) 		4 PHE A 118
ILE A 117
GLY A  98
CYH A  95
 None
 1.21A 3r0lD-3gs9A:
undetectable		 3r0lD-3gs9A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 PHE B 387
ILE B 619
GLY B 506
CYH B 509
HIS B 504
 None
 1.30A 3r0lD-3h0gB:
undetectable		 3r0lD-3h0gB:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF01194
(RNA_pol_N) 		4 ILE B 813
GLY B 994
CYH J  10
HIS B 985
 None
None
ZN  J1066 (-2.9A)
None
 1.40A 3r0lD-3h0gB:
undetectable		 3r0lD-3h0gB:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hij DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
anthracis) 		PF00701
(DHDPS) 		4 PHE A 121
ILE A 145
GLY A 116
HIS A 120
 None
 1.32A 3r0lD-3hijA:
undetectable		 3r0lD-3hijA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6y ESTERASE APC40077

(Oleispira
antarctica) 		PF00756
(Esterase) 		4 PHE A 171
ILE A 262
GLY A 146
HIS A 269
 None
 1.03A 3r0lD-3i6yA:
undetectable		 3r0lD-3i6yA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3km5 LYSINE SPECIFIC
CYSTEINE PROTEASE

(Porphyromonas
gingivalis) 		PF07675
(Cleaved_Adhesin) 		4 ILE A1323
GLY A1246
CYH A1317
HIS A1248
 None
 1.16A 3r0lD-3km5A:
undetectable		 3r0lD-3km5A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Pectobacterium
atrosepticum) 		PF00155
(Aminotran_1_2) 		4 PHE A 148
ILE A 121
GLY A 143
HIS A 147
 None
None
EDO  A  23 ( 3.3A)
EDO  A   4 (-3.9A)
 1.39A 3r0lD-3ly1A:
undetectable		 3r0lD-3ly1A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma2 METALLOPROTEINASE
INHIBITOR 1

(Homo sapiens) 		PF00965
(TIMP) 		4 PHE B 323
ILE B 340
GLY B 325
HIS B 374
 None
 1.34A 3r0lD-3ma2B:
undetectable		 3r0lD-3ma2B:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mf9 ENDO-1,4-BETA-XYLANA
SE

(Thermopolyspora
flexuosa) 		PF00457
(Glyco_hydro_11) 		4 PHE A 156
ILE A 152
GLY A  80
HIS A 169
 None
 0.93A 3r0lD-3mf9A:
undetectable		 3r0lD-3mf9A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT

(Ruegeria
pomeroyi) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PHE A 503
ILE A 292
GLY A 497
HIS A 491
 None
 0.81A 3r0lD-3n6rA:
undetectable		 3r0lD-3n6rA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdk RIBULOKINASE

(Bacillus
halodurans) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 PHE A 433
ILE A 429
GLY A 312
CYH A 314
 None
 0.97A 3r0lD-3qdkA:
undetectable		 3r0lD-3qdkA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 PHE A 483
ILE A 486
GLY A  95
HIS A 152
 None
 1.07A 3r0lD-3s29A:
undetectable		 3r0lD-3s29A:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sn0 PUTATIVE
L-ALANINE-DL-GLUTAMA
TE EPIMERASE

(Paraburkholderia
xenovorans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A  35
ILE A  48
GLY A  43
HIS A  19
 None
 1.25A 3r0lD-3sn0A:
undetectable		 3r0lD-3sn0A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vot L-AMINO ACID LIGASE,
BL00235

(Bacillus
licheniformis) 		PF13535
(ATP-grasp_4) 		4 PHE A 326
ILE A 307
GLY A 328
HIS A 218
 None
 1.23A 3r0lD-3votA:
undetectable		 3r0lD-3votA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1

(Sulfolobus
solfataricus) 		PF10040
(CRISPR_Cas6) 		4 PHE A 273
ILE A 222
GLY A 270
HIS A  57
 None
 1.17A 3r0lD-3zfvA:
undetectable		 3r0lD-3zfvA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		4 PHE A 611
ILE A 576
GLY A 563
HIS A 615
 None
 1.37A 3r0lD-4areA:
undetectable		 3r0lD-4areA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au7 HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2

(Mus musculus) 		PF00856
(SET) 		4 PHE A 180
ILE A 108
GLY A 176
HIS A  32
 None
None
None
SAH  A1247 (-3.6A)
 1.01A 3r0lD-4au7A:
undetectable		 3r0lD-4au7A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 127
GLY A 113
CYH A 117
HIS A 118
 EDO  A 503 (-4.9A)
None
None
None
 1.01A 3r0lD-4bbmA:
undetectable		 3r0lD-4bbmA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		4 PHE A 263
ILE A 289
GLY A 235
CYH A 239
 None
 1.23A 3r0lD-4e0tA:
undetectable		 3r0lD-4e0tA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2

(Sulfolobus
solfataricus) 		PF10040
(CRISPR_Cas6) 		4 PHE A 274
ILE A 223
GLY A 271
HIS A  57
 None
 1.28A 3r0lD-4ilrA:
undetectable		 3r0lD-4ilrA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 PHE A1010
ILE A1021
GLY A1015
HIS A1011
 None
 1.37A 3r0lD-4j3bA:
undetectable		 3r0lD-4j3bA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5o POLYMERASE PA

(Influenza A
virus) 		PF00603
(Flu_PA) 		4 PHE A 148
ILE A 171
GLY A 121
HIS A 146
 None
None
X48  A 306 ( 4.7A)
None
 1.38A 3r0lD-4m5oA:
undetectable		 3r0lD-4m5oA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM1
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01423
(LSM)
PF01423
(LSM) 		4 PHE A  55
ILE B  60
GLY B  55
HIS B  53
 None
 1.29A 3r0lD-4m75A:
undetectable		 3r0lD-4m75A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2x DL-2-HALOACID
DEHALOGENASE

(Methylobacterium
sp. CPA1) 		PF10778
(DehI) 		4 PHE A 273
ILE A 277
GLY A  41
HIS A 189
 None
 1.29A 3r0lD-4n2xA:
undetectable		 3r0lD-4n2xA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaw XYN30D

(Paenibacillus
barcinonensis) 		PF03422
(CBM_6)
PF17189
(Glyco_hydro_30C) 		4 PHE A 210
ILE A 207
GLY A 204
HIS A 251
 None
 1.35A 3r0lD-4qawA:
undetectable		 3r0lD-4qawA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8t NS3

(Japanese
encephalitis
virus) 		PF00949
(Peptidase_S7) 		4 PHE B  85
ILE B 146
GLY B  39
HIS B  47
 None
 1.36A 3r0lD-4r8tB:
undetectable		 3r0lD-4r8tB:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1b ANTE

(Streptomyces
sp. NRRL 2288) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PHE A  38
ILE A  26
GLY A  94
HIS A 385
 None
 1.06A 3r0lD-4y1bA:
undetectable		 3r0lD-4y1bA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 PHE A  96
ILE A 173
GLY A 235
HIS A 110
 None
 1.37A 3r0lD-4ye5A:
undetectable		 3r0lD-4ye5A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 PHE A2444
GLY A2487
CYH A2515
HIS A2509
 None
 1.26A 3r0lD-4z37A:
undetectable		 3r0lD-4z37A:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 PHE A 676
GLY A 718
CYH A 746
HIS A 740
 None
 1.21A 3r0lD-4zdnA:
undetectable		 3r0lD-4zdnA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwn MONOGLYCERIDE LIPASE

(Saccharomyces
cerevisiae) 		PF12146
(Hydrolase_4) 		4 PHE A 262
ILE A 245
GLY A 127
CYH A 129
 None
 1.21A 3r0lD-4zwnA:
undetectable		 3r0lD-4zwnA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 PHE A 187
ILE A 153
GLY A 149
HIS A 191
 None
 1.29A 3r0lD-5btrA:
undetectable		 3r0lD-5btrA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B

(Homo sapiens) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 PHE A 242
ILE A 268
GLY A 240
HIS A 226
 None
 1.36A 3r0lD-5dseA:
undetectable		 3r0lD-5dseA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1

(Homo sapiens) 		PF04622
(ERG2_Sigma1R) 		4 PHE A  37
ILE A  42
GLY A 174
HIS A  97
 None
 1.31A 3r0lD-5hk2A:
undetectable		 3r0lD-5hk2A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		4 PHE A 502
ILE A 527
GLY A 603
CYH A 611
 None
 1.38A 3r0lD-5hp5A:
undetectable		 3r0lD-5hp5A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mv9 UNCONVENTIONAL
MYOSIN-VIIA

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4) 		4 PHE A2114
ILE A2141
GLY A2025
HIS A2027
 None
 1.38A 3r0lD-5mv9A:
undetectable		 3r0lD-5mv9A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		4 PHE C 364
ILE C 503
GLY C 472
HIS C 470
 None
 1.22A 3r0lD-5tw1C:
undetectable		 3r0lD-5tw1C:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		4 PHE A  43
GLY A 177
CYH A 156
HIS A 160
 None
 1.33A 3r0lD-5u24A:
undetectable		 3r0lD-5u24A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wti CRISPR-ASSOCIATED
PROTEIN

(Bacillus
thermoamylovorans) 		no annotation 4 PHE Z 616
ILE Z 585
GLY Z 805
HIS Z 802
 None
G  B  17 ( 4.0A)
G  B  17 ( 4.1A)
None
 1.17A 3r0lD-5wtiZ:
undetectable		 3r0lD-5wtiZ:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Pseudomonas
aeruginosa) 		no annotation 4 PHE B  74
ILE B  32
GLY B 123
CYH B 127
 None
None
MRD  B 301 (-3.4A)
None
 1.31A 3r0lD-5wybB:
undetectable		 3r0lD-5wybB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Pseudomonas
aeruginosa) 		no annotation 4 PHE A 127
ILE A 116
GLY A  73
HIS A 131
 None
 1.17A 3r0lD-5wyrA:
undetectable		 3r0lD-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzm GROUP IIE SECRETORY
PHOSPHOLIPASE A2

(Homo sapiens) 		no annotation 4 PHE A   5
ILE A   9
GLY A  28
HIS A  46
 None
None
CA  A 210 (-4.3A)
None
 0.61A 3r0lD-5wzmA:
20.9		 3r0lD-5wzmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ypt STILBENECARBOXYLATE
SYNTHASE 1

(Marchantia
polymorpha) 		no annotation 4 PHE A 375
ILE A 277
GLY A 308
HIS A 305
 None
 1.32A 3r0lD-5yptA:
undetectable		 3r0lD-5yptA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 4 ILE A 860
GLY A 846
CYH A 850
HIS A 851
 None
 1.07A 3r0lD-6b3eA:
undetectable		 3r0lD-6b3eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4r STAPHYLOPINE
DEHYDROGENASE

(Staphylococcus
aureus) 		no annotation 4 PHE A 143
ILE A 115
GLY A 173
CYH A 182
 None
 1.27A 3r0lD-6c4rA:
undetectable		 3r0lD-6c4rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		no annotation 4 PHE A 784
ILE A 785
GLY A 717
HIS A 665
 None
 1.08A 3r0lD-6cg0A:
undetectable		 3r0lD-6cg0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cqb CHALCONE SYNTHASE

(Piper
methysticum) 		no annotation 4 PHE A 374
ILE A 276
GLY A 307
HIS A 304
 None
 1.14A 3r0lD-6cqbA:
undetectable		 3r0lD-6cqbA:
undetectable