SIMILAR PATTERNS OF AMINO ACIDS FOR 3QXV_E_MTXE2000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE


(Escherichia
coli)
PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C)
5 ARG A 204
ARG A 336
VAL A 213
ALA A 328
TYR A 225
None
1.29A 3qxvE-1guqA:
undetectable
3qxvE-1guqA:
15.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i3u ANTIBODY VHH LAMA
DOMAIN


(Lama glama)
PF07686
(V-set)
5 ALA A  24
ARG A  77
VAL A  84
ALA A 103
TYR A 118
None
None
None
None
CGN  A   1 ( 4.0A)
0.85A 3qxvE-1i3uA:
18.3
3qxvE-1i3uA:
59.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j33 COBT

(Thermus
thermophilus)
PF02277
(DBI_PRT)
5 ALA A 204
ARG A 200
SER A  64
VAL A 225
ALA A 172
None
1.20A 3qxvE-1j33A:
undetectable
3qxvE-1j33A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A


(Spinacia
oleracea)
no annotation 5 ALA O 257
SER O 294
SER O 295
VAL O 160
ALA O 263
None
1.33A 3qxvE-1jn0O:
undetectable
3qxvE-1jn0O:
15.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kxt IMMUNOGLOBULIN VHH
FRAGMENT


(Camelus
dromedarius)
PF07686
(V-set)
5 ALA B  24
MET B  34
ARG B  71
ALA B  94
TYR B 102
None
1.07A 3qxvE-1kxtB:
16.3
3qxvE-1kxtB:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pz5 HEAVY CHAIN OF FAB
(SYA/J6)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 ALA B  24
MET B  34
ARG B  71
VAL B  78
TYR B 102
None
0.94A 3qxvE-1pz5B:
16.4
3qxvE-1pz5B:
51.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qd0 VHH-R2 ANTI-RR6
ANTIBODY


(Lama glama)
PF07686
(V-set)
5 MET A  37
ARG A  75
VAL A  82
ALA A 101
TYR A 117
None
1.02A 3qxvE-1qd0A:
16.5
3qxvE-1qd0A:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1shm ANTIBODY RIG

(Lama glama)
PF07686
(V-set)
5 CYH A  22
ALA A  24
SER A  30
VAL A  78
ALA A  94
None
0.97A 3qxvE-1shmA:
18.2
3qxvE-1shmA:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1shm ANTIBODY RIG

(Lama glama)
PF07686
(V-set)
5 CYH A  22
SER A  30
MET A  34
VAL A  78
ALA A  94
None
1.01A 3qxvE-1shmA:
18.2
3qxvE-1shmA:
65.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT


(Pseudomonas
putida)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
5 ALA B 314
ARG B 416
SER B 354
ARG B 188
ALA B 177
None
1.22A 3qxvE-1t3qB:
undetectable
3qxvE-1t3qB:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT


(Pseudomonas
putida)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
5 ALA B 314
ARG B 416
SER B 354
ARG B 188
VAL B 186
None
0.83A 3qxvE-1t3qB:
undetectable
3qxvE-1t3qB:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis)
PF01341
(Glyco_hydro_6)
5 ALA A 268
SER A 298
SER A 292
VAL A 226
TYR A 242
None
1.31A 3qxvE-1up2A:
undetectable
3qxvE-1up2A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN


(Human
alphaherpesvirus
1)
PF00747
(Viral_DNA_bp)
5 ALA A 243
SER A  92
TYR A  95
VAL A  46
ALA A  39
None
1.30A 3qxvE-1urjA:
undetectable
3qxvE-1urjA:
8.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ck0 HEAVY CHAIN)
PROTEIN
(IMMUNOGLOBULIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 CYH H  22
ALA H  24
MET H  34
ARG H  71
TYR H 106
None
1.15A 3qxvE-2ck0H:
16.7
3qxvE-2ck0H:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgv TAGATOSE-6-PHOSPHATE
KINASE


(Staphylococcus
aureus)
PF00294
(PfkB)
5 ALA A 230
ARG A 238
SER A 222
VAL A 181
ALA A 277
None
1.08A 3qxvE-2jgvA:
undetectable
3qxvE-2jgvA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxy ALIPHATIC AMIDASE

(Pseudomonas
aeruginosa)
PF00795
(CN_hydrolase)
5 ALA A 256
ARG A   2
SER A   8
TYR A 255
VAL A  17
None
1.31A 3qxvE-2uxyA:
undetectable
3qxvE-2uxyA:
16.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x6m HEAVY CHAIN VARIABLE
DOMAIN FROM
DROMEDARY


(Camelus
dromedarius)
PF07686
(V-set)
5 MET A  34
ARG A  73
VAL A  80
ALA A  99
TYR A 115
None
1.05A 3qxvE-2x6mA:
17.4
3qxvE-2x6mA:
70.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xa3 LLAMA HEAVY CHAIN
ANTIBODY D7


(Lama glama)
PF07686
(V-set)
5 SER A  29
MET A  34
VAL A  78
ALA A  94
TYR A 102
SO4  A1114 (-2.7A)
None
None
None
None
0.77A 3qxvE-2xa3A:
17.2
3qxvE-2xa3A:
69.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp0 MEMBRANE PROTEIN
IMPLICATED IN
REGULATION OF
MEMBRANE PROTEASE
ACTIVITY


(Corynebacterium
glutamicum)
PF01957
(NfeD)
5 ALA A  26
SER A  44
TRP A  46
VAL A  32
ALA A  73
None
1.03A 3qxvE-3cp0A:
undetectable
3qxvE-3cp0A:
23.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g9a MINIMIZER

(Camelus
dromedarius)
PF07686
(V-set)
6 ALA B  24
MET B  34
ARG B  71
VAL B  78
ALA B  94
TYR B 102
None
0.68A 3qxvE-3g9aB:
16.4
3qxvE-3g9aB:
64.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkf ALDOLASE LSRF

(Escherichia
coli)
no annotation 5 CYH O 239
ALA O 235
SER O 259
VAL O 250
ALA O 268
None
1.15A 3qxvE-3gkfO:
undetectable
3qxvE-3gkfO:
14.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k7u ANTIBODY

(Lama glama)
PF07686
(V-set)
5 MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 111
None
0.51A 3qxvE-3k7uA:
18.7
3qxvE-3k7uA:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ln9 IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN B10


(Camelidae)
PF07686
(V-set)
5 ALA A  24
ARG A  72
VAL A  79
ALA A  98
TYR A 113
None
None
None
None
GOL  A 137 (-4.8A)
0.84A 3qxvE-3ln9A:
16.0
3qxvE-3ln9A:
67.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
5 ALA A  26
SER A  30
VAL A  81
ALA A 100
TYR A 120
None
0.98A 3qxvE-3qxuA:
20.4
3qxvE-3qxuA:
96.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
7 ALA A  26
SER A  31
MET A  36
ARG A  74
VAL A  81
ALA A 100
TYR A 120
None
0.88A 3qxvE-3qxuA:
20.4
3qxvE-3qxuA:
96.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
7 SER A  31
TRP A  34
MET A  36
ARG A  74
VAL A  81
ALA A 100
TYR A 120
None
1.44A 3qxvE-3qxuA:
20.4
3qxvE-3qxuA:
96.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qyc VH DOMAIN OF IGG
MOLECULE


(Homo sapiens)
PF07686
(V-set)
5 CYH A  24
ALA A  26
MET A  36
ARG A  74
VAL A  81
None
0.69A 3qxvE-3qycA:
16.4
3qxvE-3qycA:
61.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sge HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 ALA H  24
SER H  28
MET H  34
ARG H  74
TYR H 104
None
1.02A 3qxvE-3sgeH:
16.5
3qxvE-3sgeH:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3stb SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
5 ALA A  26
MET A  36
ARG A  73
VAL A  80
ALA A  99
None
0.66A 3qxvE-3stbA:
18.4
3qxvE-3stbA:
70.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX


(Homo sapiens)
PF03097
(BRO1)
5 CYH A 187
ARG A 145
VAL A 184
ALA A 119
TYR A 122
None
1.15A 3qxvE-3um1A:
undetectable
3qxvE-3um1A:
15.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aq1 NBKB6

(Lama glama)
PF07686
(V-set)
5 MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 113
None
1.03A 3qxvE-4aq1B:
18.2
3qxvE-4aq1B:
74.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bk1 PROBABLE SALICYLATE
MONOOXYGENASE


(Rhodococcus
jostii)
PF01494
(FAD_binding_3)
5 ALA A 252
SER A 213
TYR A 253
ALA A 184
TYR A 183
None
1.22A 3qxvE-4bk1A:
undetectable
3qxvE-4bk1A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bm1 MANGANESE PEROXIDASE
4


(Pleurotus
ostreatus)
PF00141
(peroxidase)
PF11895
(Peroxidase_ext)
5 ALA A 115
ARG A 126
SER A 286
ARG A 133
ALA A 270
None
1.20A 3qxvE-4bm1A:
undetectable
3qxvE-4bm1A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE


(Gelatoporia
subvermispora)
PF00141
(peroxidase)
PF11895
(Peroxidase_ext)
5 ALA A 111
ARG A 122
SER A 294
ARG A 129
ALA A 278
None
1.17A 3qxvE-4czpA:
undetectable
3qxvE-4czpA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dka SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
6 ALA A  24
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 116
None
0.76A 3qxvE-4dkaA:
18.4
3qxvE-4dkaA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eig CA1698 CAMEL
ANTIBODY FRAGMENT


(Lama glama)
PF07686
(V-set)
6 ALA B  24
MET B  34
ARG B  71
VAL B  78
ALA B  97
TYR B 106
None
0.70A 3qxvE-4eigB:
16.5
3qxvE-4eigB:
66.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ej1 NB113 CAMELID
ANTIBODY FRAGMENT


(Lama glama)
PF07686
(V-set)
5 ALA C  97
SER C 101
ARG C  72
VAL C  79
ALA C  50
None
1.16A 3qxvE-4ej1C:
17.6
3qxvE-4ej1C:
74.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fhb NB179

(Lama glama)
PF07686
(V-set)
5 MET D  34
ARG D  72
VAL D  79
ALA D  98
TYR D 118
None
0.51A 3qxvE-4fhbD:
18.3
3qxvE-4fhbD:
71.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gft NANOBODY

(Lama glama)
PF07686
(V-set)
5 MET B  36
ARG B  74
VAL B  81
ALA B 100
TYR B 115
None
None
None
None
PCA  B   2 ( 3.9A)
0.37A 3qxvE-4gftB:
18.6
3qxvE-4gftB:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hem ANTI-BASEPLATE
TP901-1 LLAMA VHH 02


(Lama glama)
PF07686
(V-set)
6 ALA E  24
MET E  34
ARG E  72
VAL E  79
ALA E  98
TYR E 112
None
0.68A 3qxvE-4hemE:
19.7
3qxvE-4hemE:
73.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4n INTRACELLULAR
PROTEASE/AMIDASE


(Vibrio cholerae)
no annotation 5 ALA A 142
SER A  93
TYR A 149
VAL A 173
ALA A  97
None
1.22A 3qxvE-4i4nA:
undetectable
3qxvE-4i4nA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila)
PF10487
(Nup188)
5 ALA A1075
ARG A1072
SER A1070
VAL A1029
ALA A1006
None
1.24A 3qxvE-4kf7A:
undetectable
3qxvE-4kf7A:
8.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krm NANOBODY/VHH DOMAIN
7D12


(Lama glama)
PF07686
(V-set)
6 ALA B  24
MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 113
None
0.76A 3qxvE-4krmB:
19.7
3qxvE-4krmB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krn NANOBODY/VHH DOMAIN
EGA1


(Lama glama)
PF07686
(V-set)
5 ARG A  27
MET A  34
VAL A  79
ALA A  98
TYR A 119
None
1.29A 3qxvE-4krnA:
17.2
3qxvE-4krnA:
70.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lf0 ALIPHATIC AMIDASE

(Bacillus sp.
(in: Bacteria))
PF00795
(CN_hydrolase)
5 ALA A 256
ARG A   2
SER A   8
TYR A 255
VAL A  17
None
1.32A 3qxvE-4lf0A:
undetectable
3qxvE-4lf0A:
15.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lhq CAMELID NANOBODY

(Vicugna pacos)
PF07686
(V-set)
6 CYH B  22
ALA B  24
SER B  28
MET B  34
ARG B  72
VAL B  79
None
0.94A 3qxvE-4lhqB:
18.3
3qxvE-4lhqB:
63.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m3k CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-H7S


(Lama glama)
PF07686
(V-set)
5 SER B  29
MET B  34
ARG B  71
VAL B  78
ALA B  97
None
1.24A 3qxvE-4m3kB:
15.1
3qxvE-4m3kB:
68.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nc1 A20.1 VHH

(Lama glama)
PF07686
(V-set)
6 ALA C  31
MET C  41
ARG C  79
VAL C  86
ALA C 105
TYR C 119
None
0.98A 3qxvE-4nc1C:
18.3
3qxvE-4nc1C:
70.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nc2 B39 VHH

(Lama glama)
PF07686
(V-set)
5 ALA B  24
MET B  34
ARG B  71
ALA B  97
TYR B 111
None
0.81A 3qxvE-4nc2B:
19.2
3qxvE-4nc2B:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION


(Lama glama)
PF07686
(V-set)
5 MET G  34
ARG G  71
VAL G  78
ALA G  97
TYR G 111
None
0.57A 3qxvE-4p2cG:
16.0
3qxvE-4p2cG:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION


(Lama glama)
PF07686
(V-set)
5 SER G  27
MET G  34
VAL G  78
ALA G  97
TYR G 111
None
1.27A 3qxvE-4p2cG:
16.0
3qxvE-4p2cG:
70.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE


(Alicyclobacillus
acidocaldarius)
PF01636
(APH)
5 ALA A  86
SER A 112
TRP A 110
VAL A  89
ALA A  56
None
None
HIS  A 401 (-3.7A)
None
HIS  A 401 (-3.5A)
1.22A 3qxvE-4pdyA:
undetectable
3qxvE-4pdyA:
17.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qlr LLAMA NANOBODY N02
VH DOMAIN


(Lama glama)
PF07686
(V-set)
5 ALA A  24
ARG A  72
VAL A  79
ALA A  98
TYR A 113
None
0.83A 3qxvE-4qlrA:
18.6
3qxvE-4qlrA:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qo1 NB139 NANOBODY
AGAINST THE
DNA-BINDING DOMAIN
OF P53


(Lama glama)
PF07686
(V-set)
6 ALA A  25
MET A  35
ARG A  73
VAL A  80
ALA A  99
TYR A 113
None
0.62A 3qxvE-4qo1A:
18.1
3qxvE-4qo1A:
62.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpk PHOSPHOTRANSFERASE

(Brucella
abortus)
PF10090
(HPTransfase)
5 ALA A  65
ARG A  19
SER A  26
ALA A  60
TYR A  91
GOL  A 301 (-3.6A)
GOL  A 302 (-3.0A)
None
None
GOL  A 301 (-4.9A)
1.30A 3qxvE-4qpkA:
undetectable
3qxvE-4qpkA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tvs VHH DOMAIN BS-1

(Vicugna pacos)
PF05609
(LAP1C)
6 CYH a  23
ALA a  25
ARG a  73
VAL a  80
ALA a  99
TYR a 117
None
0.82A 3qxvE-4tvsa:
18.7
3qxvE-4tvsa:
72.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w6y NANOBODY NBFEDF9

(Lama glama)
PF07686
(V-set)
5 ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 118
None
0.99A 3qxvE-4w6yB:
17.6
3qxvE-4w6yB:
69.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w6y NANOBODY NBFEDF9

(Lama glama)
PF07686
(V-set)
5 MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 118
None
1.31A 3qxvE-4w6yB:
17.6
3qxvE-4w6yB:
69.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4weu ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION


(Lama glama)
PF07686
(V-set)
5 ALA D 824
MET D 834
ARG D 872
ALA D 898
TYR D 910
None
0.66A 3qxvE-4weuD:
18.5
3qxvE-4weuD:
72.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj1 ANTIGEN MTB48,
MYCOBACTERIAL
PROTEIN


(Mycolicibacterium
smegmatis)
no annotation 5 ALA A 220
SER A  41
TYR A 266
VAL A 225
ALA A 150
None
1.16A 3qxvE-4wj1A:
undetectable
3qxvE-4wj1A:
17.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xt1 NANOBODY 7

(Vicugna pacos)
PF07686
(V-set)
5 ALA C  24
MET C  34
VAL C  78
ALA C  97
TYR C 107
None
0.87A 3qxvE-4xt1C:
16.2
3qxvE-4xt1C:
68.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2k IG LAMBDA-1 CHAIN V
REGION S43


(Mus musculus)
PF07686
(V-set)
5 ALA H  24
MET H  34
ARG H  71
VAL H  78
TYR H 102
None
0.78A 3qxvE-5a2kH:
16.4
3qxvE-5a2kH:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czr CADHERIN-RELATED
FAMILY MEMBER 2


(Homo sapiens)
PF00028
(Cadherin)
5 ALA A  62
MET A  42
VAL A  52
ALA A  47
TYR A  48
None
1.28A 3qxvE-5czrA:
undetectable
3qxvE-5czrA:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fwo NANOBODY

(Lama glama)
PF07686
(V-set)
5 ALA A  24
MET A  34
ARG A  71
VAL A  78
TYR A 102
None
0.86A 3qxvE-5fwoA:
18.2
3qxvE-5fwoA:
68.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fwo NANOBODY

(Lama glama)
PF07686
(V-set)
5 MET A  34
ARG A  71
VAL A  78
ALA A  94
TYR A 102
None
0.58A 3qxvE-5fwoA:
18.2
3qxvE-5fwoA:
68.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gru DIABODY PROTEIN

(Mus musculus)
PF07686
(V-set)
5 ALA L 153
SER L 214
SER L 215
MET L 125
ALA L 146
ALA  L 153 ( 0.0A)
SER  L 214 ( 0.0A)
SER  L 215 ( 0.0A)
MET  L 125 ( 0.0A)
ALA  L 146 ( 0.0A)
1.25A 3qxvE-5gruL:
16.2
3qxvE-5gruL:
44.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gxb NANOBODY

(Vicugna pacos)
PF07686
(V-set)
6 CYH B  22
ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 118
None
0.81A 3qxvE-5gxbB:
17.4
3qxvE-5gxbB:
68.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hvf VHH-I83

(Vicugna pacos)
PF07686
(V-set)
5 ALA B  24
MET B  34
VAL B  77
ALA B  96
TYR B 108
None
1.00A 3qxvE-5hvfB:
15.1
3qxvE-5hvfB:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iml NANOBODY

(Camelidae)
PF07686
(V-set)
5 ALA B  23
MET B  33
ARG B  71
ALA B  97
TYR B 113
None
0.82A 3qxvE-5imlB:
19.9
3qxvE-5imlB:
75.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iml NANOBODY

(Camelidae)
PF07686
(V-set)
5 MET B  33
ARG B  71
VAL B  78
ALA B  97
TYR B 113
None
0.43A 3qxvE-5imlB:
19.9
3qxvE-5imlB:
75.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j1s VHH DOMAIN BS-2

(Vicugna pacos)
PF07686
(V-set)
6 ALA C  25
MET C  35
ARG C  72
VAL C  79
ALA C  98
TYR C 112
None
0.89A 3qxvE-5j1sC:
15.9
3qxvE-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j1s VHH DOMAIN BS-2

(Vicugna pacos)
PF07686
(V-set)
5 CYH C  23
ALA C  25
VAL C  79
ALA C  98
TYR C 112
None
0.68A 3qxvE-5j1sC:
15.9
3qxvE-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j1s VHH DOMAIN BS-2

(Vicugna pacos)
PF07686
(V-set)
5 CYH C  23
SER C  31
VAL C  79
ALA C  98
TYR C 112
None
1.27A 3qxvE-5j1sC:
15.9
3qxvE-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j56 VHH SINGLE CHAIN
ANTIBODY V1C7


(Vicugna pacos)
PF07686
(V-set)
6 CYH B  22
ALA B  24
ARG B  76
VAL B  83
ALA B 102
TYR B 117
None
0.68A 3qxvE-5j56B:
17.5
3qxvE-5j56B:
67.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jds NANOBODY

(Camelidae)
PF07686
(V-set)
5 SER B  29
MET B  34
VAL B  79
ALA B  98
TYR B 117
None
1.08A 3qxvE-5jdsB:
16.7
3qxvE-5jdsB:
67.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jqh NANOBODY60, NB60

(Lama glama)
no annotation 5 MET D  34
ARG D  71
VAL D  78
ALA D  97
TYR D 108
None
0.94A 3qxvE-5jqhD:
16.1
3qxvE-5jqhD:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kel C2G4 VARIABLE FAB
DOMAIN HEAVY CHAIN


(Homo sapiens)
PF07686
(V-set)
5 ALA H  24
MET H  34
ARG H  71
VAL H  78
TYR H 102
None
0.85A 3qxvE-5kelH:
14.8
3qxvE-5kelH:
51.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lhq CAMELID-DERIVED
ANTIBODY FRAGMENT
NB7


(Vicugna pacos)
PF07686
(V-set)
5 ALA B  24
ARG B  72
VAL B  79
ALA B  98
TYR B 122
None
0.51A 3qxvE-5lhqB:
18.1
3qxvE-5lhqB:
64.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmj NANOBODY

(Lama glama)
PF07686
(V-set)
6 ALA A  24
MET A  34
ARG A  71
VAL A  78
ALA A  94
TYR A 102
None
0.95A 3qxvE-5lmjA:
16.7
3qxvE-5lmjA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S


(Lama glama)
no annotation 5 ALA C  27
MET C  37
ARG C  75
ALA C 101
TYR C 117
None
None
None
None
ACT  C 202 (-4.4A)
0.58A 3qxvE-5lwfC:
18.5
3qxvE-5lwfC:
68.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S


(Lama glama)
no annotation 5 MET C  37
ARG C  75
VAL C  82
ALA C 101
TYR C 117
None
None
None
None
ACT  C 202 (-4.4A)
0.54A 3qxvE-5lwfC:
18.5
3qxvE-5lwfC:
68.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o8f NANOBODY NB25

(Lama glama)
no annotation 5 MET L  34
ARG L  72
VAL L  79
ALA L  98
TYR L 114
None
0.55A 3qxvE-5o8fL:
18.1
3qxvE-5o8fL:
68.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tws HUMAN DNA POLYMERASE
MU


(Homo sapiens)
PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm)
5 ALA A 159
SER A 209
SER A 210
VAL A 228
ALA A 164
None
1.31A 3qxvE-5twsA:
undetectable
3qxvE-5twsA:
15.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u3j DH511.1 HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
5 CYH H  22
ALA H  24
MET H  34
ARG H  71
ALA H  94
None
0.94A 3qxvE-5u3jH:
16.0
3qxvE-5u3jH:
54.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uk4 ANTI-VESICULAR
STOMATITIS VIRUS N
VHH


(Vicugna pacos)
no annotation 5 MET p  34
ARG p  72
VAL p  79
ALA p  98
TYR p 114
None
0.70A 3qxvE-5uk4p:
17.7
3qxvE-5uk4p:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ukb ANTI-VESICULAR
STOMATITIS VIRUS N
VHH


(Vicugna pacos)
no annotation 5 ALA d  24
ARG d  72
VAL d  79
ALA d  98
TYR d 113
None
0.75A 3qxvE-5ukbd:
19.3
3qxvE-5ukbd:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vaq NB914

(Lama glama)
no annotation 5 ALA B  24
SER B  30
ARG B  72
VAL B  79
ALA B  98
None
1.05A 3qxvE-5vaqB:
19.3
3qxvE-5vaqB:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3


(Vicugna pacos)
no annotation 5 MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 108
None
0.61A 3qxvE-5vxjB:
15.7
3qxvE-5vxjB:
63.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3


(Vicugna pacos)
no annotation 6 CYH B  22
ALA B  24
MET B  34
ARG B  73
ALA B  99
TYR B 106
None
0.80A 3qxvE-5vxlB:
16.6
3qxvE-5vxlB:
66.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3


(Vicugna pacos)
no annotation 6 CYH B  22
MET B  34
ARG B  73
VAL B  80
ALA B  99
TYR B 106
None
0.66A 3qxvE-5vxlB:
16.6
3qxvE-5vxlB:
66.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa3 PYRIDINE SYNTHASE
TBTD


(Thermobispora
bispora)
no annotation 5 ALA A 343
SER A 229
TYR A 347
VAL A 183
ALA A 173
None
1.20A 3qxvE-5wa3A:
undetectable
3qxvE-5wa3A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN


(Human
betaherpesvirus
5;
Lama glama)
no annotation 5 ALA A1024
MET A1034
VAL A1078
ALA A1097
TYR A1107
None
0.97A 3qxvE-5wb1A:
15.0
3qxvE-5wb1A:
15.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wb2 NANOBODY B1

(synthetic
construct)
no annotation 5 ALA D  24
ARG D  72
VAL D  79
ALA D  98
TYR D 118
None
0.97A 3qxvE-5wb2D:
15.8
3qxvE-5wb2D:
68.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN


(Mus musculus)
no annotation 5 ALA A  43
MET A  53
ARG A  93
VAL A 100
TYR A 124
None
0.79A 3qxvE-5x0tA:
16.4
3qxvE-5x0tA:
31.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1


(Mus musculus)
no annotation 5 ALA A1174
ARG A1176
SER A1250
VAL A1742
TYR A1184
None
1.30A 3qxvE-6b3rA:
undetectable
3qxvE-6b3rA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbe NANOBODY VHH R303

(Lama glama)
no annotation 5 ALA A  24
MET A  34
VAL A  79
ALA A  98
TYR A 107
None
0.78A 3qxvE-6dbeA:
17.1
3qxvE-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbe NANOBODY VHH R303

(Lama glama)
no annotation 6 SER A  30
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 107
None
1.18A 3qxvE-6dbeA:
17.1
3qxvE-6dbeA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ehg HC3NB1

(Lama glama)
no annotation 5 MET C  34
ARG C  72
VAL C  79
ALA C  98
TYR C 112
None
0.59A 3qxvE-6ehgC:
18.8
3qxvE-6ehgC:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ey0 LLAMA NANOBODY NB01

(Lama glama)
no annotation 5 MET E  34
ARG E  71
VAL E  78
ALA E  94
TYR E 102
None
0.80A 3qxvE-6ey0E:
18.0
3qxvE-6ey0E:
56.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gzp NANOBODY

(Lama glama)
no annotation 5 ALA A  24
MET A  34
ARG A  71
ALA A  94
TYR A 102
None
0.83A 3qxvE-6gzpA:
18.4
3qxvE-6gzpA:
undetectable