SIMILAR PATTERNS OF AMINO ACIDS FOR 3QXV_E_MTXE2000
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1guq | GALACTOSE-1-PHOSPHATEURIDYLYLTRANSFERASE (Escherichiacoli) |
PF01087(GalP_UDP_transf)PF02744(GalP_UDP_tr_C) | 5 | ARG A 204ARG A 336VAL A 213ALA A 328TYR A 225 | None | 1.29A | 3qxvE-1guqA:undetectable | 3qxvE-1guqA:15.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1i3u | ANTIBODY VHH LAMADOMAIN (Lama glama) |
PF07686(V-set) | 5 | ALA A 24ARG A 77VAL A 84ALA A 103TYR A 118 | NoneNoneNoneNoneCGN A 1 ( 4.0A) | 0.85A | 3qxvE-1i3uA:18.3 | 3qxvE-1i3uA:59.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j33 | COBT (Thermusthermophilus) |
PF02277(DBI_PRT) | 5 | ALA A 204ARG A 200SER A 64VAL A 225ALA A 172 | None | 1.20A | 3qxvE-1j33A:undetectable | 3qxvE-1j33A:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jn0 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASEA (Spinaciaoleracea) |
no annotation | 5 | ALA O 257SER O 294SER O 295VAL O 160ALA O 263 | None | 1.33A | 3qxvE-1jn0O:undetectable | 3qxvE-1jn0O:15.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kxt | IMMUNOGLOBULIN VHHFRAGMENT (Camelusdromedarius) |
PF07686(V-set) | 5 | ALA B 24MET B 34ARG B 71ALA B 94TYR B 102 | None | 1.07A | 3qxvE-1kxtB:16.3 | 3qxvE-1kxtB:68.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pz5 | HEAVY CHAIN OF FAB(SYA/J6) (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 5 | ALA B 24MET B 34ARG B 71VAL B 78TYR B 102 | None | 0.94A | 3qxvE-1pz5B:16.4 | 3qxvE-1pz5B:51.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qd0 | VHH-R2 ANTI-RR6ANTIBODY (Lama glama) |
PF07686(V-set) | 5 | MET A 37ARG A 75VAL A 82ALA A 101TYR A 117 | None | 1.02A | 3qxvE-1qd0A:16.5 | 3qxvE-1qd0A:71.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1shm | ANTIBODY RIG (Lama glama) |
PF07686(V-set) | 5 | CYH A 22ALA A 24SER A 30VAL A 78ALA A 94 | None | 0.97A | 3qxvE-1shmA:18.2 | 3qxvE-1shmA:65.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1shm | ANTIBODY RIG (Lama glama) |
PF07686(V-set) | 5 | CYH A 22SER A 30MET A 34VAL A 78ALA A 94 | None | 1.01A | 3qxvE-1shmA:18.2 | 3qxvE-1shmA:65.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3q | QUINOLINE2-OXIDOREDUCTASELARGE SUBUNIT (Pseudomonasputida) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | ALA B 314ARG B 416SER B 354ARG B 188ALA B 177 | None | 1.22A | 3qxvE-1t3qB:undetectable | 3qxvE-1t3qB:10.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3q | QUINOLINE2-OXIDOREDUCTASELARGE SUBUNIT (Pseudomonasputida) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | ALA B 314ARG B 416SER B 354ARG B 188VAL B 186 | None | 0.83A | 3qxvE-1t3qB:undetectable | 3qxvE-1t3qB:10.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1up2 | CELA1 PROTEIN (Mycobacteriumtuberculosis) |
PF01341(Glyco_hydro_6) | 5 | ALA A 268SER A 298SER A 292VAL A 226TYR A 242 | None | 1.31A | 3qxvE-1up2A:undetectable | 3qxvE-1up2A:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1urj | MAJOR DNA-BINDINGPROTEIN (Humanalphaherpesvirus1) |
PF00747(Viral_DNA_bp) | 5 | ALA A 243SER A 92TYR A 95VAL A 46ALA A 39 | None | 1.30A | 3qxvE-1urjA:undetectable | 3qxvE-1urjA:8.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ck0 | HEAVY CHAIN)PROTEIN(IMMUNOGLOBULIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 5 | CYH H 22ALA H 24MET H 34ARG H 71TYR H 106 | None | 1.15A | 3qxvE-2ck0H:16.7 | 3qxvE-2ck0H:36.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jgv | TAGATOSE-6-PHOSPHATEKINASE (Staphylococcusaureus) |
PF00294(PfkB) | 5 | ALA A 230ARG A 238SER A 222VAL A 181ALA A 277 | None | 1.08A | 3qxvE-2jgvA:undetectable | 3qxvE-2jgvA:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uxy | ALIPHATIC AMIDASE (Pseudomonasaeruginosa) |
PF00795(CN_hydrolase) | 5 | ALA A 256ARG A 2SER A 8TYR A 255VAL A 17 | None | 1.31A | 3qxvE-2uxyA:undetectable | 3qxvE-2uxyA:16.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2x6m | HEAVY CHAIN VARIABLEDOMAIN FROMDROMEDARY (Camelusdromedarius) |
PF07686(V-set) | 5 | MET A 34ARG A 73VAL A 80ALA A 99TYR A 115 | None | 1.05A | 3qxvE-2x6mA:17.4 | 3qxvE-2x6mA:70.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xa3 | LLAMA HEAVY CHAINANTIBODY D7 (Lama glama) |
PF07686(V-set) | 5 | SER A 29MET A 34VAL A 78ALA A 94TYR A 102 | SO4 A1114 (-2.7A)NoneNoneNoneNone | 0.77A | 3qxvE-2xa3A:17.2 | 3qxvE-2xa3A:69.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cp0 | MEMBRANE PROTEINIMPLICATED INREGULATION OFMEMBRANE PROTEASEACTIVITY (Corynebacteriumglutamicum) |
PF01957(NfeD) | 5 | ALA A 26SER A 44TRP A 46VAL A 32ALA A 73 | None | 1.03A | 3qxvE-3cp0A:undetectable | 3qxvE-3cp0A:23.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3g9a | MINIMIZER (Camelusdromedarius) |
PF07686(V-set) | 6 | ALA B 24MET B 34ARG B 71VAL B 78ALA B 94TYR B 102 | None | 0.68A | 3qxvE-3g9aB:16.4 | 3qxvE-3g9aB:64.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gkf | ALDOLASE LSRF (Escherichiacoli) |
no annotation | 5 | CYH O 239ALA O 235SER O 259VAL O 250ALA O 268 | None | 1.15A | 3qxvE-3gkfO:undetectable | 3qxvE-3gkfO:14.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3k7u | ANTIBODY (Lama glama) |
PF07686(V-set) | 5 | MET A 34ARG A 72VAL A 79ALA A 98TYR A 111 | None | 0.51A | 3qxvE-3k7uA:18.7 | 3qxvE-3k7uA:73.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ln9 | IMMUNOGLOBULIN HEAVYCHAIN ANTIBODYVARIABLE DOMAIN B10 (Camelidae) |
PF07686(V-set) | 5 | ALA A 24ARG A 72VAL A 79ALA A 98TYR A 113 | NoneNoneNoneNoneGOL A 137 (-4.8A) | 0.84A | 3qxvE-3ln9A:16.0 | 3qxvE-3ln9A:67.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3qxu | ANTI-METHOTREXATECDR1-3 GRAFT (Lama glama) |
PF07686(V-set) | 5 | ALA A 26SER A 30VAL A 81ALA A 100TYR A 120 | None | 0.98A | 3qxvE-3qxuA:20.4 | 3qxvE-3qxuA:96.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3qxu | ANTI-METHOTREXATECDR1-3 GRAFT (Lama glama) |
PF07686(V-set) | 7 | ALA A 26SER A 31MET A 36ARG A 74VAL A 81ALA A 100TYR A 120 | None | 0.88A | 3qxvE-3qxuA:20.4 | 3qxvE-3qxuA:96.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3qxu | ANTI-METHOTREXATECDR1-3 GRAFT (Lama glama) |
PF07686(V-set) | 7 | SER A 31TRP A 34MET A 36ARG A 74VAL A 81ALA A 100TYR A 120 | None | 1.44A | 3qxvE-3qxuA:20.4 | 3qxvE-3qxuA:96.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3qyc | VH DOMAIN OF IGGMOLECULE (Homo sapiens) |
PF07686(V-set) | 5 | CYH A 24ALA A 26MET A 36ARG A 74VAL A 81 | None | 0.69A | 3qxvE-3qycA:16.4 | 3qxvE-3qycA:61.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3sge | HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 5 | ALA H 24SER H 28MET H 34ARG H 74TYR H 104 | None | 1.02A | 3qxvE-3sgeH:16.5 | 3qxvE-3sgeH:37.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3stb | SINGLE DOMAINANTIBODY VHH (Lama glama) |
PF07686(V-set) | 5 | ALA A 26MET A 36ARG A 73VAL A 80ALA A 99 | None | 0.66A | 3qxvE-3stbA:18.4 | 3qxvE-3stbA:70.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3um1 | BRO1DOMAIN-CONTAININGPROTEIN BROX (Homo sapiens) |
PF03097(BRO1) | 5 | CYH A 187ARG A 145VAL A 184ALA A 119TYR A 122 | None | 1.15A | 3qxvE-3um1A:undetectable | 3qxvE-3um1A:15.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4aq1 | NBKB6 (Lama glama) |
PF07686(V-set) | 5 | MET B 34ARG B 72VAL B 79ALA B 98TYR B 113 | None | 1.03A | 3qxvE-4aq1B:18.2 | 3qxvE-4aq1B:74.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bk1 | PROBABLE SALICYLATEMONOOXYGENASE (Rhodococcusjostii) |
PF01494(FAD_binding_3) | 5 | ALA A 252SER A 213TYR A 253ALA A 184TYR A 183 | None | 1.22A | 3qxvE-4bk1A:undetectable | 3qxvE-4bk1A:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bm1 | MANGANESE PEROXIDASE4 (Pleurotusostreatus) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 5 | ALA A 115ARG A 126SER A 286ARG A 133ALA A 270 | None | 1.20A | 3qxvE-4bm1A:undetectable | 3qxvE-4bm1A:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4czp | EXTRALONG MANGANESEPEROXIDASE (Gelatoporiasubvermispora) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 5 | ALA A 111ARG A 122SER A 294ARG A 129ALA A 278 | None | 1.17A | 3qxvE-4czpA:undetectable | 3qxvE-4czpA:16.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dka | SINGLE DOMAINANTIBODY VHH (Lama glama) |
PF07686(V-set) | 6 | ALA A 24MET A 34ARG A 72VAL A 79ALA A 98TYR A 116 | None | 0.76A | 3qxvE-4dkaA:18.4 | 3qxvE-4dkaA:73.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4eig | CA1698 CAMELANTIBODY FRAGMENT (Lama glama) |
PF07686(V-set) | 6 | ALA B 24MET B 34ARG B 71VAL B 78ALA B 97TYR B 106 | None | 0.70A | 3qxvE-4eigB:16.5 | 3qxvE-4eigB:66.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ej1 | NB113 CAMELIDANTIBODY FRAGMENT (Lama glama) |
PF07686(V-set) | 5 | ALA C 97SER C 101ARG C 72VAL C 79ALA C 50 | None | 1.16A | 3qxvE-4ej1C:17.6 | 3qxvE-4ej1C:74.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fhb | NB179 (Lama glama) |
PF07686(V-set) | 5 | MET D 34ARG D 72VAL D 79ALA D 98TYR D 118 | None | 0.51A | 3qxvE-4fhbD:18.3 | 3qxvE-4fhbD:71.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4gft | NANOBODY (Lama glama) |
PF07686(V-set) | 5 | MET B 36ARG B 74VAL B 81ALA B 100TYR B 115 | NoneNoneNoneNonePCA B 2 ( 3.9A) | 0.37A | 3qxvE-4gftB:18.6 | 3qxvE-4gftB:66.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hem | ANTI-BASEPLATETP901-1 LLAMA VHH 02 (Lama glama) |
PF07686(V-set) | 6 | ALA E 24MET E 34ARG E 72VAL E 79ALA E 98TYR E 112 | None | 0.68A | 3qxvE-4hemE:19.7 | 3qxvE-4hemE:73.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i4n | INTRACELLULARPROTEASE/AMIDASE (Vibrio cholerae) |
no annotation | 5 | ALA A 142SER A 93TYR A 149VAL A 173ALA A 97 | None | 1.22A | 3qxvE-4i4nA:undetectable | 3qxvE-4i4nA:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kf7 | NUP188 (Thermothelomycesthermophila) |
PF10487(Nup188) | 5 | ALA A1075ARG A1072SER A1070VAL A1029ALA A1006 | None | 1.24A | 3qxvE-4kf7A:undetectable | 3qxvE-4kf7A:8.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4krm | NANOBODY/VHH DOMAIN7D12 (Lama glama) |
PF07686(V-set) | 6 | ALA B 24MET B 34ARG B 72VAL B 79ALA B 98TYR B 113 | None | 0.76A | 3qxvE-4krmB:19.7 | 3qxvE-4krmB:70.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4krn | NANOBODY/VHH DOMAINEGA1 (Lama glama) |
PF07686(V-set) | 5 | ARG A 27MET A 34VAL A 79ALA A 98TYR A 119 | None | 1.29A | 3qxvE-4krnA:17.2 | 3qxvE-4krnA:70.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lf0 | ALIPHATIC AMIDASE (Bacillus sp.(in: Bacteria)) |
PF00795(CN_hydrolase) | 5 | ALA A 256ARG A 2SER A 8TYR A 255VAL A 17 | None | 1.32A | 3qxvE-4lf0A:undetectable | 3qxvE-4lf0A:15.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lhq | CAMELID NANOBODY (Vicugna pacos) |
PF07686(V-set) | 6 | CYH B 22ALA B 24SER B 28MET B 34ARG B 72VAL B 79 | None | 0.94A | 3qxvE-4lhqB:18.3 | 3qxvE-4lhqB:63.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m3k | CAMELID HEAVY-CHAINANTIBODY VARIABLEFRAGMENT CAB-H7S (Lama glama) |
PF07686(V-set) | 5 | SER B 29MET B 34ARG B 71VAL B 78ALA B 97 | None | 1.24A | 3qxvE-4m3kB:15.1 | 3qxvE-4m3kB:68.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nc1 | A20.1 VHH (Lama glama) |
PF07686(V-set) | 6 | ALA C 31MET C 41ARG C 79VAL C 86ALA C 105TYR C 119 | None | 0.98A | 3qxvE-4nc1C:18.3 | 3qxvE-4nc1C:70.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nc2 | B39 VHH (Lama glama) |
PF07686(V-set) | 5 | ALA B 24MET B 34ARG B 71ALA B 97TYR B 111 | None | 0.81A | 3qxvE-4nc2B:19.2 | 3qxvE-4nc2B:70.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p2c | NANOBODY 1,ANTI-F4+ETECBACTERIA VHHVARIABLE REGION (Lama glama) |
PF07686(V-set) | 5 | MET G 34ARG G 71VAL G 78ALA G 97TYR G 111 | None | 0.57A | 3qxvE-4p2cG:16.0 | 3qxvE-4p2cG:70.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p2c | NANOBODY 1,ANTI-F4+ETECBACTERIA VHHVARIABLE REGION (Lama glama) |
PF07686(V-set) | 5 | SER G 27MET G 34VAL G 78ALA G 97TYR G 111 | None | 1.27A | 3qxvE-4p2cG:16.0 | 3qxvE-4p2cG:70.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pdy | AMINOGLYCOSIDEPHOSPHOTRANSFERASE (Alicyclobacillusacidocaldarius) |
PF01636(APH) | 5 | ALA A 86SER A 112TRP A 110VAL A 89ALA A 56 | NoneNoneHIS A 401 (-3.7A)NoneHIS A 401 (-3.5A) | 1.22A | 3qxvE-4pdyA:undetectable | 3qxvE-4pdyA:17.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4qlr | LLAMA NANOBODY N02VH DOMAIN (Lama glama) |
PF07686(V-set) | 5 | ALA A 24ARG A 72VAL A 79ALA A 98TYR A 113 | None | 0.83A | 3qxvE-4qlrA:18.6 | 3qxvE-4qlrA:69.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4qo1 | NB139 NANOBODYAGAINST THEDNA-BINDING DOMAINOF P53 (Lama glama) |
PF07686(V-set) | 6 | ALA A 25MET A 35ARG A 73VAL A 80ALA A 99TYR A 113 | None | 0.62A | 3qxvE-4qo1A:18.1 | 3qxvE-4qo1A:62.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qpk | PHOSPHOTRANSFERASE (Brucellaabortus) |
PF10090(HPTransfase) | 5 | ALA A 65ARG A 19SER A 26ALA A 60TYR A 91 | GOL A 301 (-3.6A)GOL A 302 (-3.0A)NoneNoneGOL A 301 (-4.9A) | 1.30A | 3qxvE-4qpkA:undetectable | 3qxvE-4qpkA:20.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4tvs | VHH DOMAIN BS-1 (Vicugna pacos) |
PF05609(LAP1C) | 6 | CYH a 23ALA a 25ARG a 73VAL a 80ALA a 99TYR a 117 | None | 0.82A | 3qxvE-4tvsa:18.7 | 3qxvE-4tvsa:72.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4w6y | NANOBODY NBFEDF9 (Lama glama) |
PF07686(V-set) | 5 | ALA B 24MET B 34VAL B 79ALA B 98TYR B 118 | None | 0.99A | 3qxvE-4w6yB:17.6 | 3qxvE-4w6yB:69.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4w6y | NANOBODY NBFEDF9 (Lama glama) |
PF07686(V-set) | 5 | MET B 34ARG B 72VAL B 79ALA B 98TYR B 118 | None | 1.31A | 3qxvE-4w6yB:17.6 | 3qxvE-4w6yB:69.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4weu | ANTI-F4+ETECBACTERIA VHHVARIABLE REGION (Lama glama) |
PF07686(V-set) | 5 | ALA D 824MET D 834ARG D 872ALA D 898TYR D 910 | None | 0.66A | 3qxvE-4weuD:18.5 | 3qxvE-4weuD:72.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wj1 | ANTIGEN MTB48,MYCOBACTERIALPROTEIN (Mycolicibacteriumsmegmatis) |
no annotation | 5 | ALA A 220SER A 41TYR A 266VAL A 225ALA A 150 | None | 1.16A | 3qxvE-4wj1A:undetectable | 3qxvE-4wj1A:17.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xt1 | NANOBODY 7 (Vicugna pacos) |
PF07686(V-set) | 5 | ALA C 24MET C 34VAL C 78ALA C 97TYR C 107 | None | 0.87A | 3qxvE-4xt1C:16.2 | 3qxvE-4xt1C:68.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a2k | IG LAMBDA-1 CHAIN VREGION S43 (Mus musculus) |
PF07686(V-set) | 5 | ALA H 24MET H 34ARG H 71VAL H 78TYR H 102 | None | 0.78A | 3qxvE-5a2kH:16.4 | 3qxvE-5a2kH:29.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5czr | CADHERIN-RELATEDFAMILY MEMBER 2 (Homo sapiens) |
PF00028(Cadherin) | 5 | ALA A 62MET A 42VAL A 52ALA A 47TYR A 48 | None | 1.28A | 3qxvE-5czrA:undetectable | 3qxvE-5czrA:18.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fwo | NANOBODY (Lama glama) |
PF07686(V-set) | 5 | ALA A 24MET A 34ARG A 71VAL A 78TYR A 102 | None | 0.86A | 3qxvE-5fwoA:18.2 | 3qxvE-5fwoA:68.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fwo | NANOBODY (Lama glama) |
PF07686(V-set) | 5 | MET A 34ARG A 71VAL A 78ALA A 94TYR A 102 | None | 0.58A | 3qxvE-5fwoA:18.2 | 3qxvE-5fwoA:68.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5gru | DIABODY PROTEIN (Mus musculus) |
PF07686(V-set) | 5 | ALA L 153SER L 214SER L 215MET L 125ALA L 146 | ALA L 153 ( 0.0A)SER L 214 ( 0.0A)SER L 215 ( 0.0A)MET L 125 ( 0.0A)ALA L 146 ( 0.0A) | 1.25A | 3qxvE-5gruL:16.2 | 3qxvE-5gruL:44.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5gxb | NANOBODY (Vicugna pacos) |
PF07686(V-set) | 6 | CYH B 22ALA B 24MET B 34VAL B 79ALA B 98TYR B 118 | None | 0.81A | 3qxvE-5gxbB:17.4 | 3qxvE-5gxbB:68.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hvf | VHH-I83 (Vicugna pacos) |
PF07686(V-set) | 5 | ALA B 24MET B 34VAL B 77ALA B 96TYR B 108 | None | 1.00A | 3qxvE-5hvfB:15.1 | 3qxvE-5hvfB:69.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5iml | NANOBODY (Camelidae) |
PF07686(V-set) | 5 | ALA B 23MET B 33ARG B 71ALA B 97TYR B 113 | None | 0.82A | 3qxvE-5imlB:19.9 | 3qxvE-5imlB:75.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5iml | NANOBODY (Camelidae) |
PF07686(V-set) | 5 | MET B 33ARG B 71VAL B 78ALA B 97TYR B 113 | None | 0.43A | 3qxvE-5imlB:19.9 | 3qxvE-5imlB:75.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5j1s | VHH DOMAIN BS-2 (Vicugna pacos) |
PF07686(V-set) | 6 | ALA C 25MET C 35ARG C 72VAL C 79ALA C 98TYR C 112 | None | 0.89A | 3qxvE-5j1sC:15.9 | 3qxvE-5j1sC:66.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5j1s | VHH DOMAIN BS-2 (Vicugna pacos) |
PF07686(V-set) | 5 | CYH C 23ALA C 25VAL C 79ALA C 98TYR C 112 | None | 0.68A | 3qxvE-5j1sC:15.9 | 3qxvE-5j1sC:66.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5j1s | VHH DOMAIN BS-2 (Vicugna pacos) |
PF07686(V-set) | 5 | CYH C 23SER C 31VAL C 79ALA C 98TYR C 112 | None | 1.27A | 3qxvE-5j1sC:15.9 | 3qxvE-5j1sC:66.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5j56 | VHH SINGLE CHAINANTIBODY V1C7 (Vicugna pacos) |
PF07686(V-set) | 6 | CYH B 22ALA B 24ARG B 76VAL B 83ALA B 102TYR B 117 | None | 0.68A | 3qxvE-5j56B:17.5 | 3qxvE-5j56B:67.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jds | NANOBODY (Camelidae) |
PF07686(V-set) | 5 | SER B 29MET B 34VAL B 79ALA B 98TYR B 117 | None | 1.08A | 3qxvE-5jdsB:16.7 | 3qxvE-5jdsB:67.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jqh | NANOBODY60, NB60 (Lama glama) |
no annotation | 5 | MET D 34ARG D 71VAL D 78ALA D 97TYR D 108 | None | 0.94A | 3qxvE-5jqhD:16.1 | 3qxvE-5jqhD:70.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5kel | C2G4 VARIABLE FABDOMAIN HEAVY CHAIN (Homo sapiens) |
PF07686(V-set) | 5 | ALA H 24MET H 34ARG H 71VAL H 78TYR H 102 | None | 0.85A | 3qxvE-5kelH:14.8 | 3qxvE-5kelH:51.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lhq | CAMELID-DERIVEDANTIBODY FRAGMENTNB7 (Vicugna pacos) |
PF07686(V-set) | 5 | ALA B 24ARG B 72VAL B 79ALA B 98TYR B 122 | None | 0.51A | 3qxvE-5lhqB:18.1 | 3qxvE-5lhqB:64.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lmj | NANOBODY (Lama glama) |
PF07686(V-set) | 6 | ALA A 24MET A 34ARG A 71VAL A 78ALA A 94TYR A 102 | None | 0.95A | 3qxvE-5lmjA:16.7 | 3qxvE-5lmjA:73.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lwf | CAMELID HEAVY-CHAINANTIBODY VARIABLEFRAGMENT CAB-G10S (Lama glama) |
no annotation | 5 | ALA C 27MET C 37ARG C 75ALA C 101TYR C 117 | NoneNoneNoneNoneACT C 202 (-4.4A) | 0.58A | 3qxvE-5lwfC:18.5 | 3qxvE-5lwfC:68.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lwf | CAMELID HEAVY-CHAINANTIBODY VARIABLEFRAGMENT CAB-G10S (Lama glama) |
no annotation | 5 | MET C 37ARG C 75VAL C 82ALA C 101TYR C 117 | NoneNoneNoneNoneACT C 202 (-4.4A) | 0.54A | 3qxvE-5lwfC:18.5 | 3qxvE-5lwfC:68.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5o8f | NANOBODY NB25 (Lama glama) |
no annotation | 5 | MET L 34ARG L 72VAL L 79ALA L 98TYR L 114 | None | 0.55A | 3qxvE-5o8fL:18.1 | 3qxvE-5o8fL:68.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tws | HUMAN DNA POLYMERASEMU (Homo sapiens) |
PF10391(DNA_pol_lambd_f)PF14716(HHH_8)PF14791(DNA_pol_B_thumb)PF14792(DNA_pol_B_palm) | 5 | ALA A 159SER A 209SER A 210VAL A 228ALA A 164 | None | 1.31A | 3qxvE-5twsA:undetectable | 3qxvE-5twsA:15.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5u3j | DH511.1 HEAVY CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 5 | CYH H 22ALA H 24MET H 34ARG H 71ALA H 94 | None | 0.94A | 3qxvE-5u3jH:16.0 | 3qxvE-5u3jH:54.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5uk4 | ANTI-VESICULARSTOMATITIS VIRUS NVHH (Vicugna pacos) |
no annotation | 5 | MET p 34ARG p 72VAL p 79ALA p 98TYR p 114 | None | 0.70A | 3qxvE-5uk4p:17.7 | 3qxvE-5uk4p:71.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ukb | ANTI-VESICULARSTOMATITIS VIRUS NVHH (Vicugna pacos) |
no annotation | 5 | ALA d 24ARG d 72VAL d 79ALA d 98TYR d 113 | None | 0.75A | 3qxvE-5ukbd:19.3 | 3qxvE-5ukbd:70.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vaq | NB914 (Lama glama) |
no annotation | 5 | ALA B 24SER B 30ARG B 72VAL B 79ALA B 98 | None | 1.05A | 3qxvE-5vaqB:19.3 | 3qxvE-5vaqB:75.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vxj | SINGLE-DOMAINANTIBODY JMK-E3 (Vicugna pacos) |
no annotation | 5 | MET B 34ARG B 72VAL B 79ALA B 98TYR B 108 | None | 0.61A | 3qxvE-5vxjB:15.7 | 3qxvE-5vxjB:63.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vxl | SINGLE-DOMAINANTIBODY JPS-G3 (Vicugna pacos) |
no annotation | 6 | CYH B 22ALA B 24MET B 34ARG B 73ALA B 99TYR B 106 | None | 0.80A | 3qxvE-5vxlB:16.6 | 3qxvE-5vxlB:66.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vxl | SINGLE-DOMAINANTIBODY JPS-G3 (Vicugna pacos) |
no annotation | 6 | CYH B 22MET B 34ARG B 73VAL B 80ALA B 99TYR B 106 | None | 0.66A | 3qxvE-5vxlB:16.6 | 3qxvE-5vxlB:66.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wa3 | PYRIDINE SYNTHASETBTD (Thermobisporabispora) |
no annotation | 5 | ALA A 343SER A 229TYR A 347VAL A 183ALA A 173 | None | 1.20A | 3qxvE-5wa3A:undetectable | 3qxvE-5wa3A:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wb1 | ENVELOPE PROTEINUS28, NANOBODY 7FUSION PROTEIN (Humanbetaherpesvirus5;Lama glama) |
no annotation | 5 | ALA A1024MET A1034VAL A1078ALA A1097TYR A1107 | None | 0.97A | 3qxvE-5wb1A:15.0 | 3qxvE-5wb1A:15.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5wb2 | NANOBODY B1 (syntheticconstruct) |
no annotation | 5 | ALA D 24ARG D 72VAL D 79ALA D 98TYR D 118 | None | 0.97A | 3qxvE-5wb2D:15.8 | 3qxvE-5wb2D:68.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5x0t | 6H8 FAB FRAGMENTHEAVY CHAIN (Mus musculus) |
no annotation | 5 | ALA A 43MET A 53ARG A 93VAL A 100TYR A 124 | None | 0.79A | 3qxvE-5x0tA:16.4 | 3qxvE-5x0tA:31.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b3r | PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT 1 (Mus musculus) |
no annotation | 5 | ALA A1174ARG A1176SER A1250VAL A1742TYR A1184 | None | 1.30A | 3qxvE-6b3rA:undetectable | 3qxvE-6b3rA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dbe | NANOBODY VHH R303 (Lama glama) |
no annotation | 5 | ALA A 24MET A 34VAL A 79ALA A 98TYR A 107 | None | 0.78A | 3qxvE-6dbeA:17.1 | 3qxvE-6dbeA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dbe | NANOBODY VHH R303 (Lama glama) |
no annotation | 6 | SER A 30MET A 34ARG A 72VAL A 79ALA A 98TYR A 107 | None | 1.18A | 3qxvE-6dbeA:17.1 | 3qxvE-6dbeA:undetectable | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6ehg | HC3NB1 (Lama glama) |
no annotation | 5 | MET C 34ARG C 72VAL C 79ALA C 98TYR C 112 | None | 0.59A | 3qxvE-6ehgC:18.8 | 3qxvE-6ehgC:57.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6ey0 | LLAMA NANOBODY NB01 (Lama glama) |
no annotation | 5 | MET E 34ARG E 71VAL E 78ALA E 94TYR E 102 | None | 0.80A | 3qxvE-6ey0E:18.0 | 3qxvE-6ey0E:56.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gzp | NANOBODY (Lama glama) |
no annotation | 5 | ALA A 24MET A 34ARG A 71ALA A 94TYR A 102 | None | 0.83A | 3qxvE-6gzpA:18.4 | 3qxvE-6gzpA:undetectable |