SIMILAR PATTERNS OF AMINO ACIDS FOR 3QXV_D_MTXD2000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g6v ANTIBODY HEAVY CHAIN

(Camelus
dromedarius)
PF07686
(V-set)
5 VAL K 802
ALA K 824
MET K 834
VAL K 877
TYR K 915
None
0.69A 3qxvD-1g6vK:
20.1
3qxvD-1g6vK:
69.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i3u ANTIBODY VHH LAMA
DOMAIN


(Lama glama)
PF07686
(V-set)
5 ALA A  24
ARG A  77
VAL A  84
ALA A 103
TYR A 118
None
None
None
None
CGN  A   1 ( 4.0A)
0.84A 3qxvD-1i3uA:
20.8
3qxvD-1i3uA:
59.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kxt IMMUNOGLOBULIN VHH
FRAGMENT


(Camelus
dromedarius)
PF07686
(V-set)
5 VAL B   2
ALA B  24
MET B  34
ALA B  94
TYR B 102
None
0.98A 3qxvD-1kxtB:
19.2
3qxvD-1kxtB:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pz5 HEAVY CHAIN OF FAB
(SYA/J6)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL B   2
ALA B  24
MET B  34
ARG B  71
VAL B  78
None
0.79A 3qxvD-1pz5B:
19.9
3qxvD-1pz5B:
51.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT


(Pseudomonas
putida)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
5 ALA B 314
ARG B 416
SER B 354
ARG B 188
VAL B 186
None
0.93A 3qxvD-1t3qB:
undetectable
3qxvD-1t3qB:
10.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t66 IMMUNOGLOBULIN HEAVY
CHAIN


(Mus musculus)
no annotation 5 ALA H  24
MET H  34
ARG H  74
VAL H  81
TYR H 107
None
0.79A 3qxvD-1t66H:
19.3
3qxvD-1t66H:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t66 IMMUNOGLOBULIN HEAVY
CHAIN


(Mus musculus)
no annotation 5 VAL H   2
MET H  34
ARG H  74
VAL H  81
TYR H 107
None
0.76A 3qxvD-1t66H:
19.3
3qxvD-1t66H:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x6m HEAVY CHAIN VARIABLE
DOMAIN FROM
DROMEDARY


(Camelus
dromedarius)
PF07686
(V-set)
5 ALA A  24
MET A  34
VAL A  80
ALA A  99
TYR A 115
None
0.66A 3qxvD-2x6mA:
21.1
3qxvD-2x6mA:
70.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xa3 LLAMA HEAVY CHAIN
ANTIBODY D7


(Lama glama)
PF07686
(V-set)
5 SER A  29
MET A  34
VAL A  78
ALA A  94
TYR A 102
SO4  A1114 (-2.7A)
None
None
None
None
0.68A 3qxvD-2xa3A:
20.8
3qxvD-2xa3A:
69.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g9a MINIMIZER

(Camelus
dromedarius)
PF07686
(V-set)
7 VAL B   2
ALA B  24
MET B  34
ARG B  71
VAL B  78
ALA B  94
TYR B 102
None
0.83A 3qxvD-3g9aB:
19.5
3qxvD-3g9aB:
64.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3if1 IMMUNOGLOBULIN HEAVY
CHAIN (IGG2A)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL B   2
ALA B  24
MET B  34
ARG B  71
TYR B 102
None
0.70A 3qxvD-3if1B:
19.5
3qxvD-3if1B:
32.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k7u ANTIBODY

(Lama glama)
PF07686
(V-set)
5 MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 111
None
0.39A 3qxvD-3k7uA:
21.9
3qxvD-3k7uA:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ln9 IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN B10


(Camelidae)
PF07686
(V-set)
5 ALA A  24
ARG A  72
VAL A  79
ALA A  98
TYR A 113
None
None
None
None
GOL  A 137 (-4.8A)
0.77A 3qxvD-3ln9A:
19.2
3qxvD-3ln9A:
67.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
6 SER A  30
TRP A  34
MET A  36
VAL A  81
ALA A 100
TYR A 120
None
1.48A 3qxvD-3qxuA:
24.0
3qxvD-3qxuA:
96.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
7 SER A  31
TRP A  34
MET A  36
ARG A  74
VAL A  81
ALA A 100
TYR A 120
None
1.40A 3qxvD-3qxuA:
24.0
3qxvD-3qxuA:
96.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
7 VAL A   4
ALA A  26
SER A  30
MET A  36
VAL A  81
ALA A 100
TYR A 120
None
0.90A 3qxvD-3qxuA:
24.0
3qxvD-3qxuA:
96.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
8 VAL A   4
ALA A  26
SER A  31
MET A  36
ARG A  74
VAL A  81
ALA A 100
TYR A 120
None
0.88A 3qxvD-3qxuA:
24.0
3qxvD-3qxuA:
96.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qyc VH DOMAIN OF IGG
MOLECULE


(Homo sapiens)
PF07686
(V-set)
5 VAL A   4
ALA A  26
MET A  36
ARG A  74
VAL A  81
None
0.69A 3qxvD-3qycA:
19.8
3qxvD-3qycA:
61.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r0m LLAMA VHH A12

(Lama glama)
PF07686
(V-set)
5 ALA A  24
SER A  29
MET A  34
VAL A  78
ALA A  94
None
SO4  A 131 (-2.7A)
None
None
None
0.94A 3qxvD-3r0mA:
21.2
3qxvD-3r0mA:
70.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3stb SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
5 ALA A  26
MET A  36
ARG A  73
VAL A  80
ALA A  99
None
0.65A 3qxvD-3stbA:
22.0
3qxvD-3stbA:
70.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tpk IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN KW1


(Camelidae)
PF07686
(V-set)
5 VAL A   2
ALA A  24
VAL A  79
ALA A  98
TYR A 110
None
BEN  A 133 (-3.6A)
BEN  A 133 (-4.6A)
BEN  A 133 ( 4.2A)
None
0.92A 3qxvD-3tpkA:
20.3
3qxvD-3tpkA:
64.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aq1 NBKB6

(Lama glama)
PF07686
(V-set)
5 MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 113
None
0.97A 3qxvD-4aq1B:
21.8
3qxvD-4aq1B:
74.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b41 ANTIBODY G7

(Lama glama)
PF07686
(V-set)
5 VAL A   2
ALA A  24
MET A  34
VAL A  78
ALA A  97
None
0.90A 3qxvD-4b41A:
18.6
3qxvD-4b41A:
72.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dka SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
7 VAL A   2
ALA A  24
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 116
None
0.81A 3qxvD-4dkaA:
22.0
3qxvD-4dkaA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eig CA1698 CAMEL
ANTIBODY FRAGMENT


(Lama glama)
PF07686
(V-set)
6 ALA B  24
MET B  34
ARG B  71
VAL B  78
ALA B  97
TYR B 106
None
0.72A 3qxvD-4eigB:
20.2
3qxvD-4eigB:
66.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fhb NB179

(Lama glama)
PF07686
(V-set)
5 MET D  34
ARG D  72
VAL D  79
ALA D  98
TYR D 118
None
0.60A 3qxvD-4fhbD:
21.2
3qxvD-4fhbD:
71.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gft NANOBODY

(Lama glama)
PF07686
(V-set)
5 MET B  36
ARG B  74
VAL B  81
ALA B 100
TYR B 115
None
None
None
None
PCA  B   2 ( 3.9A)
0.38A 3qxvD-4gftB:
22.0
3qxvD-4gftB:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hem ANTI-BASEPLATE
TP901-1 LLAMA VHH 02


(Lama glama)
PF07686
(V-set)
6 ALA E  24
MET E  34
ARG E  72
VAL E  79
ALA E  98
TYR E 112
None
0.64A 3qxvD-4hemE:
22.6
3qxvD-4hemE:
73.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hlz FAB C179 HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL G   2
MET G  34
ARG G  71
VAL G  78
TYR G 102
None
0.78A 3qxvD-4hlzG:
19.0
3qxvD-4hlzG:
53.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hxa 13D9 FAB HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H   2
MET H  34
ARG H  71
VAL H  78
TYR H 102
None
0.90A 3qxvD-4hxaH:
20.6
3qxvD-4hxaH:
53.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krm NANOBODY/VHH DOMAIN
7D12


(Lama glama)
PF07686
(V-set)
6 ALA B  24
MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 113
None
0.71A 3qxvD-4krmB:
23.3
3qxvD-4krmB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krm NANOBODY/VHH DOMAIN
7D12


(Lama glama)
PF07686
(V-set)
5 SER B  29
MET B  34
VAL B  79
ALA B  98
TYR B 113
None
0.98A 3qxvD-4krmB:
23.3
3qxvD-4krmB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde CAMELID ANTIBODY
FRAGMENT


(Lama glama)
PF07686
(V-set)
5 VAL B   2
ALA B  24
ARG B  71
VAL B  78
TYR B 109
None
0.91A 3qxvD-4ldeB:
19.3
3qxvD-4ldeB:
68.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde CAMELID ANTIBODY
FRAGMENT


(Lama glama)
PF07686
(V-set)
5 VAL B   2
MET B  34
ARG B  71
VAL B  78
TYR B 109
None
0.77A 3qxvD-4ldeB:
19.3
3qxvD-4ldeB:
68.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lhq CAMELID NANOBODY

(Vicugna pacos)
PF07686
(V-set)
5 ALA B  24
SER B  28
MET B  34
ARG B  72
VAL B  79
None
0.83A 3qxvD-4lhqB:
21.5
3qxvD-4lhqB:
63.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt NANOBODY 9-8

(Lama glama)
PF07686
(V-set)
5 VAL B   2
ALA B  24
VAL B  82
ALA B 101
TYR B 110
None
0.81A 3qxvD-4mqtB:
19.2
3qxvD-4mqtB:
64.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1h CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-F11N


(Lama glama)
PF07686
(V-set)
5 ALA B  24
MET B  34
ARG B  72
VAL B  79
ALA B  98
None
0.81A 3qxvD-4n1hB:
21.3
3qxvD-4n1hB:
68.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nc1 A20.1 VHH

(Lama glama)
PF07686
(V-set)
7 VAL C   9
ALA C  31
MET C  41
ARG C  79
VAL C  86
ALA C 105
TYR C 119
None
0.90A 3qxvD-4nc1C:
22.0
3qxvD-4nc1C:
70.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nc2 B39 VHH

(Lama glama)
PF07686
(V-set)
5 ALA B  24
MET B  34
ARG B  71
ALA B  97
TYR B 111
None
0.75A 3qxvD-4nc2B:
22.8
3qxvD-4nc2B:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nc2 B39 VHH

(Lama glama)
PF07686
(V-set)
5 VAL B   2
MET B  34
ARG B  71
ALA B  97
TYR B 111
None
0.63A 3qxvD-4nc2B:
22.8
3qxvD-4nc2B:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION


(Lama glama)
PF07686
(V-set)
6 VAL G   2
MET G  34
ARG G  71
VAL G  78
ALA G  97
TYR G 111
None
0.62A 3qxvD-4p2cG:
19.1
3qxvD-4p2cG:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p49 ANTIBODY SCFV B8

(Gallus gallus)
PF07686
(V-set)
5 VAL A 122
ALA A 144
MET A 154
ARG A 193
VAL A 200
None
0.91A 3qxvD-4p49A:
21.7
3qxvD-4p49A:
51.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pb0 AB53 HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
CL  H 303 (-4.4A)
None
None
None
None
0.93A 3qxvD-4pb0H:
18.7
3qxvD-4pb0H:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qlr LLAMA NANOBODY N02
VH DOMAIN


(Lama glama)
PF07686
(V-set)
5 ALA A  24
ARG A  72
VAL A  79
ALA A  98
TYR A 113
None
0.76A 3qxvD-4qlrA:
22.4
3qxvD-4qlrA:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qo1 NB139 NANOBODY
AGAINST THE
DNA-BINDING DOMAIN
OF P53


(Lama glama)
PF07686
(V-set)
6 ALA A  25
MET A  35
ARG A  73
VAL A  80
ALA A  99
TYR A 113
None
0.57A 3qxvD-4qo1A:
21.2
3qxvD-4qo1A:
62.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tvs VHH DOMAIN BS-1

(Vicugna pacos)
PF05609
(LAP1C)
5 ALA a  25
ARG a  73
VAL a  80
ALA a  99
TYR a 117
None
0.79A 3qxvD-4tvsa:
22.1
3qxvD-4tvsa:
72.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w6y NANOBODY NBFEDF9

(Lama glama)
PF07686
(V-set)
6 VAL B   2
ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 118
None
0.92A 3qxvD-4w6yB:
21.0
3qxvD-4w6yB:
69.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4weu ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION


(Lama glama)
PF07686
(V-set)
6 VAL D 802
ALA D 824
MET D 834
ARG D 872
ALA D 898
TYR D 910
None
0.68A 3qxvD-4weuD:
22.3
3qxvD-4weuD:
72.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x8j 12F4 FAB HEAVY CHAIN

(Mus musculus)
no annotation 5 VAL H   2
MET H  34
ARG H  74
VAL H  81
TYR H 104
None
None
None
None
2PE  H 302 ( 4.6A)
0.67A 3qxvD-4x8jH:
15.5
3qxvD-4x8jH:
33.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xt1 NANOBODY 7

(Vicugna pacos)
PF07686
(V-set)
6 VAL C   2
ALA C  24
MET C  34
VAL C  78
ALA C  97
TYR C 107
None
0.87A 3qxvD-4xt1C:
19.0
3qxvD-4xt1C:
68.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2k IG LAMBDA-1 CHAIN V
REGION S43


(Mus musculus)
PF07686
(V-set)
6 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
TYR H 102
None
0.79A 3qxvD-5a2kH:
19.8
3qxvD-5a2kH:
29.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5aum HEAVY CHAIN OF FAB
FRAGMENT


(Rattus)
no annotation 5 ALA H  24
MET H  34
ARG H  71
VAL H  78
ALA H  94
None
0.67A 3qxvD-5aumH:
19.7
3qxvD-5aumH:
38.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5aum HEAVY CHAIN OF FAB
FRAGMENT


(Rattus)
no annotation 5 VAL H   2
MET H  34
ARG H  71
VAL H  78
ALA H  94
None
0.58A 3qxvD-5aumH:
19.7
3qxvD-5aumH:
38.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e1h F8(JOB10) VHH
ANTIBODY


(Vicugna pacos)
PF07686
(V-set)
5 VAL B   2
ALA B  24
MET B  34
ARG B  72
VAL B  79
None
0.83A 3qxvD-5e1hB:
20.3
3qxvD-5e1hB:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e7f NANOBODY L06

(Camelus
dromedarius)
PF07686
(V-set)
5 VAL A   4
MET A  36
ARG A  73
VAL A  80
ALA A  99
None
0.72A 3qxvD-5e7fA:
18.4
3qxvD-5e7fA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fwo NANOBODY

(Lama glama)
PF07686
(V-set)
6 VAL A   2
ALA A  24
MET A  34
ARG A  71
VAL A  78
TYR A 102
None
0.87A 3qxvD-5fwoA:
21.5
3qxvD-5fwoA:
68.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fwo NANOBODY

(Lama glama)
PF07686
(V-set)
6 VAL A   2
MET A  34
ARG A  71
VAL A  78
ALA A  94
TYR A 102
None
0.62A 3qxvD-5fwoA:
21.5
3qxvD-5fwoA:
68.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gxb NANOBODY

(Vicugna pacos)
PF07686
(V-set)
6 VAL B   2
ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 118
None
1.09A 3qxvD-5gxbB:
20.9
3qxvD-5gxbB:
68.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hm1 LAMA VHH ANTIBODY
2E7


(Lama glama)
PF07686
(V-set)
5 VAL A   2
ALA A  24
VAL A  78
ALA A  94
TYR A 102
None
0.69A 3qxvD-5hm1A:
18.7
3qxvD-5hm1A:
68.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hvf VHH-I83

(Vicugna pacos)
PF07686
(V-set)
6 VAL B   2
ALA B  24
ARG B  70
VAL B  77
ALA B  96
TYR B 108
None
0.86A 3qxvD-5hvfB:
18.5
3qxvD-5hvfB:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hvf VHH-I83

(Vicugna pacos)
PF07686
(V-set)
6 VAL B   2
ALA B  24
MET B  34
VAL B  77
ALA B  96
TYR B 108
None
0.95A 3qxvD-5hvfB:
18.5
3qxvD-5hvfB:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iml NANOBODY

(Camelidae)
PF07686
(V-set)
6 ALA B  23
MET B  33
ARG B  71
VAL B  78
ALA B  97
TYR B 113
None
0.75A 3qxvD-5imlB:
23.6
3qxvD-5imlB:
75.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j1s VHH DOMAIN BS-2

(Vicugna pacos)
PF07686
(V-set)
7 VAL C   3
ALA C  25
MET C  35
ARG C  72
VAL C  79
ALA C  98
TYR C 112
None
0.88A 3qxvD-5j1sC:
19.5
3qxvD-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j56 VHH SINGLE CHAIN
ANTIBODY V1C7


(Vicugna pacos)
PF07686
(V-set)
6 VAL B   2
ALA B  24
ARG B  76
VAL B  83
ALA B 102
TYR B 117
None
0.91A 3qxvD-5j56B:
20.7
3qxvD-5j56B:
67.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ja9 NANOBODY 6

(Lama glama)
PF07686
(V-set)
5 VAL A   3
ALA A  25
MET A  35
ARG A  73
ALA A  99
None
0.93A 3qxvD-5ja9A:
20.2
3qxvD-5ja9A:
68.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jqh NANOBODY60, NB60

(Lama glama)
no annotation 5 VAL D   2
MET D  34
ARG D  71
VAL D  78
ALA D  97
None
0.95A 3qxvD-5jqhD:
19.2
3qxvD-5jqhD:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kel C2G4 VARIABLE FAB
DOMAIN HEAVY CHAIN


(Homo sapiens)
PF07686
(V-set)
6 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
TYR H 102
None
0.99A 3qxvD-5kelH:
17.1
3qxvD-5kelH:
51.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lhq CAMELID-DERIVED
ANTIBODY FRAGMENT
NB7


(Vicugna pacos)
PF07686
(V-set)
6 VAL B   2
ALA B  24
ARG B  72
VAL B  79
ALA B  98
TYR B 122
None
0.62A 3qxvD-5lhqB:
21.6
3qxvD-5lhqB:
64.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmj NANOBODY

(Lama glama)
PF07686
(V-set)
6 ALA A  24
MET A  34
ARG A  71
VAL A  78
ALA A  94
TYR A 102
None
0.95A 3qxvD-5lmjA:
20.2
3qxvD-5lmjA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmj NANOBODY

(Lama glama)
PF07686
(V-set)
6 VAL A   2
ALA A  24
ARG A  71
VAL A  78
ALA A  94
TYR A 102
None
0.95A 3qxvD-5lmjA:
20.2
3qxvD-5lmjA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S


(Lama glama)
no annotation 6 ALA C  27
MET C  37
ARG C  75
VAL C  82
ALA C 101
TYR C 117
None
None
None
None
None
ACT  C 202 (-4.4A)
0.59A 3qxvD-5lwfC:
21.3
3qxvD-5lwfC:
68.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S


(Lama glama)
no annotation 5 VAL C   5
ARG C  75
VAL C  82
ALA C 101
TYR C 117
None
None
None
None
ACT  C 202 (-4.4A)
0.86A 3qxvD-5lwfC:
21.3
3qxvD-5lwfC:
68.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5m13 SYNTHETIC NANOBODY
L2_C06 (A-MBP#2)


(synthetic
construct)
no annotation 5 VAL B   2
ALA B  24
VAL B  79
ALA B  98
TYR B 114
None
0.93A 3qxvD-5m13B:
21.8
3qxvD-5m13B:
63.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwn LLAMA NANOBODY
RAISED AGAINST TSSK,
NBK27


(Lama glama)
PF07686
(V-set)
5 VAL N   2
ALA N  24
ARG N  71
VAL N  78
ALA N  97
None
0.94A 3qxvD-5mwnN:
18.3
3qxvD-5mwnN:
67.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwn LLAMA NANOBODY
RAISED AGAINST TSSK,
NBK27


(Lama glama)
PF07686
(V-set)
5 VAL N   2
ALA N  24
MET N  34
VAL N  78
ALA N  97
None
0.95A 3qxvD-5mwnN:
18.3
3qxvD-5mwnN:
67.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o02 NANOBODY (VHH)
NANO-4


(Vicugna pacos)
PF07686
(V-set)
5 VAL C   2
MET C  34
ARG C  72
ALA C  98
TYR C 113
None
0.66A 3qxvD-5o02C:
21.3
3qxvD-5o02C:
68.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o03 NANOBODY (VHH)
NANO-32


(Norwalk virus)
PF07686
(V-set)
5 ALA C  24
ARG C  72
VAL C  79
ALA C  98
TYR C 124
None
0.88A 3qxvD-5o03C:
20.3
3qxvD-5o03C:
63.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o04 NANOBODY (VHH)
NANO-26


(Vicugna pacos)
PF07686
(V-set)
5 VAL E   2
ALA E  24
ARG E  71
VAL E  78
TYR E 104
None
0.83A 3qxvD-5o04E:
18.7
3qxvD-5o04E:
65.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o05 NANOBODY (VHH)
NANO-42


(Vicugna pacos)
PF07686
(V-set)
5 VAL C   2
ALA C  24
SER C  29
VAL C  78
TYR C 109
None
0.90A 3qxvD-5o05C:
17.1
3qxvD-5o05C:
67.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o8f NANOBODY NB25

(Lama glama)
no annotation 5 MET L  34
ARG L  72
VAL L  79
ALA L  98
TYR L 114
None
0.62A 3qxvD-5o8fL:
21.4
3qxvD-5o8fL:
68.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uk4 ANTI-VESICULAR
STOMATITIS VIRUS N
VHH


(Vicugna pacos)
no annotation 6 VAL p   2
MET p  34
ARG p  72
VAL p  79
ALA p  98
TYR p 114
None
0.76A 3qxvD-5uk4p:
21.4
3qxvD-5uk4p:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ukb ANTI-VESICULAR
STOMATITIS VIRUS N
VHH


(Vicugna pacos)
no annotation 5 ALA d  24
ARG d  72
VAL d  79
ALA d  98
TYR d 113
None
0.74A 3qxvD-5ukbd:
22.3
3qxvD-5ukbd:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vgj VRC38.01 FAB HEAVY
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
None
0.69A 3qxvD-5vgjH:
19.1
3qxvD-5vgjH:
36.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3


(Vicugna pacos)
no annotation 6 VAL B   2
MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 108
None
0.78A 3qxvD-5vxjB:
19.2
3qxvD-5vxjB:
63.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3


(Vicugna pacos)
no annotation 5 ALA B  24
MET B  34
ARG B  73
ALA B  99
TYR B 106
None
0.69A 3qxvD-5vxlB:
20.2
3qxvD-5vxlB:
66.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3


(Vicugna pacos)
no annotation 5 MET B  34
ARG B  73
VAL B  80
ALA B  99
TYR B 106
None
0.60A 3qxvD-5vxlB:
20.2
3qxvD-5vxlB:
66.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN


(Human
betaherpesvirus
5;
Lama glama)
no annotation 6 VAL A1002
ALA A1024
MET A1034
VAL A1078
ALA A1097
TYR A1107
None
0.93A 3qxvD-5wb1A:
18.1
3qxvD-5wb1A:
15.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wb2 NANOBODY B1

(synthetic
construct)
no annotation 5 ALA D  24
ARG D  72
VAL D  79
ALA D  98
TYR D 118
None
0.91A 3qxvD-5wb2D:
18.8
3qxvD-5wb2D:
68.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN


(Mus musculus)
no annotation 5 ALA A  43
MET A  53
ARG A  93
VAL A 100
TYR A 124
None
0.76A 3qxvD-5x0tA:
19.7
3qxvD-5x0tA:
31.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN


(Mus musculus)
no annotation 5 VAL A  21
MET A  53
ARG A  93
VAL A 100
TYR A 124
None
0.73A 3qxvD-5x0tA:
19.7
3qxvD-5x0tA:
31.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5y9f HEAVY CHAIN OF FAB
FRAGMENT OF ANTIBODY
28F10


(Mus musculus)
no annotation 5 VAL L   2
ALA L  24
MET L  34
ARG L  72
TYR L 112
None
0.96A 3qxvD-5y9fL:
20.0
3qxvD-5y9fL:
57.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbe NANOBODY VHH R303

(Lama glama)
no annotation 6 SER A  30
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 107
None
1.22A 3qxvD-6dbeA:
20.4
3qxvD-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbe NANOBODY VHH R303

(Lama glama)
no annotation 6 VAL A   2
ALA A  24
MET A  34
VAL A  79
ALA A  98
TYR A 107
None
0.77A 3qxvD-6dbeA:
20.4
3qxvD-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbe NANOBODY VHH R303

(Lama glama)
no annotation 6 VAL A   2
SER A  30
MET A  34
VAL A  79
ALA A  98
TYR A 107
None
1.03A 3qxvD-6dbeA:
20.4
3qxvD-6dbeA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ehg HC3NB1

(Lama glama)
no annotation 5 ALA C  24
MET C  34
ARG C  72
VAL C  79
ALA C  98
None
0.71A 3qxvD-6ehgC:
22.4
3qxvD-6ehgC:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ehg HC3NB1

(Lama glama)
no annotation 5 MET C  34
ARG C  72
VAL C  79
ALA C  98
TYR C 112
None
0.61A 3qxvD-6ehgC:
22.4
3qxvD-6ehgC:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ehg HC3NB1

(Lama glama)
no annotation 5 VAL C   2
ALA C  24
MET C  34
ARG C  72
VAL C  79
None
0.91A 3qxvD-6ehgC:
22.4
3qxvD-6ehgC:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ehg HC3NB1

(Lama glama)
no annotation 5 VAL C   2
MET C  34
ARG C  72
VAL C  79
TYR C 112
None
0.92A 3qxvD-6ehgC:
22.4
3qxvD-6ehgC:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ey0 LLAMA NANOBODY NB01

(Lama glama)
no annotation 5 MET E  34
ARG E  71
VAL E  78
ALA E  94
TYR E 102
None
0.87A 3qxvD-6ey0E:
21.3
3qxvD-6ey0E:
56.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gzp NANOBODY

(Lama glama)
no annotation 6 VAL A   2
ALA A  24
MET A  34
ARG A  71
ALA A  94
TYR A 102
None
0.79A 3qxvD-6gzpA:
22.1
3qxvD-6gzpA:
undetectable