SIMILAR PATTERNS OF AMINO ACIDS FOR 3QXV_B_MTXB2000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g6v ANTIBODY HEAVY CHAIN

(Camelus
dromedarius)
PF07686
(V-set)
5 VAL K 802
ALA K 824
MET K 834
VAL K 877
TYR K 915
None
0.83A 3qxvB-1g6vK:
20.3
3qxvB-1g6vK:
69.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i3u ANTIBODY VHH LAMA
DOMAIN


(Lama glama)
PF07686
(V-set)
5 ALA A  24
ARG A  77
VAL A  84
ALA A 103
TYR A 118
None
None
None
None
CGN  A   1 ( 4.0A)
0.84A 3qxvB-1i3uA:
20.9
3qxvB-1i3uA:
59.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kxt IMMUNOGLOBULIN VHH
FRAGMENT


(Camelus
dromedarius)
PF07686
(V-set)
5 VAL B   2
ALA B  24
ARG B  71
ALA B  94
TYR B 102
None
0.94A 3qxvB-1kxtB:
19.2
3qxvB-1kxtB:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kxt IMMUNOGLOBULIN VHH
FRAGMENT


(Camelus
dromedarius)
PF07686
(V-set)
5 VAL B   2
ALA B  24
MET B  34
ALA B  94
TYR B 102
None
0.96A 3qxvB-1kxtB:
19.2
3qxvB-1kxtB:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pz5 HEAVY CHAIN OF FAB
(SYA/J6)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
6 VAL B   2
ALA B  24
MET B  34
ARG B  71
VAL B  78
TYR B 102
None
1.02A 3qxvB-1pz5B:
20.1
3qxvB-1pz5B:
51.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qd0 VHH-R2 ANTI-RR6
ANTIBODY


(Lama glama)
PF07686
(V-set)
5 MET A  37
ARG A  75
VAL A  82
ALA A 101
TYR A 117
None
0.99A 3qxvB-1qd0A:
19.8
3qxvB-1qd0A:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sbs MONOCLONAL ANTIBODY
3A2


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H   2
MET H  34
ARG H  74
VAL H  81
TYR H 112
None
0.87A 3qxvB-1sbsH:
19.8
3qxvB-1sbsH:
52.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t66 IMMUNOGLOBULIN HEAVY
CHAIN


(Mus musculus)
no annotation 6 VAL H   2
ALA H  24
MET H  34
ARG H  74
VAL H  81
TYR H 107
None
0.91A 3qxvB-1t66H:
19.2
3qxvB-1t66H:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9q 4M5.3
ANTI-FLUORESCEIN
SINGLE CHAIN
ANTIBODY FRAGMENT


(Homo sapiens)
PF07686
(V-set)
5 VAL A 153
MET A 185
ARG A 225
VAL A 232
TYR A 258
None
0.72A 3qxvB-1x9qA:
13.8
3qxvB-1x9qA:
29.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x6m HEAVY CHAIN VARIABLE
DOMAIN FROM
DROMEDARY


(Camelus
dromedarius)
PF07686
(V-set)
5 ALA A  24
MET A  34
VAL A  80
ALA A  99
TYR A 115
None
0.76A 3qxvB-2x6mA:
21.5
3qxvB-2x6mA:
70.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xa3 LLAMA HEAVY CHAIN
ANTIBODY D7


(Lama glama)
PF07686
(V-set)
5 SER A  29
MET A  34
VAL A  78
ALA A  94
TYR A 102
SO4  A1114 (-2.7A)
None
None
None
None
0.76A 3qxvB-2xa3A:
20.9
3qxvB-2xa3A:
69.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g9a MINIMIZER

(Camelus
dromedarius)
PF07686
(V-set)
6 ALA B  24
MET B  34
ARG B  71
VAL B  78
ALA B  94
TYR B 102
None
0.69A 3qxvB-3g9aB:
19.7
3qxvB-3g9aB:
64.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3if1 IMMUNOGLOBULIN HEAVY
CHAIN (IGG2A)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL B   2
ALA B  24
MET B  34
ARG B  71
TYR B 102
None
0.74A 3qxvB-3if1B:
19.6
3qxvB-3if1B:
32.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k7u ANTIBODY

(Lama glama)
PF07686
(V-set)
5 MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 111
None
0.47A 3qxvB-3k7uA:
22.2
3qxvB-3k7uA:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ln9 IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN B10


(Camelidae)
PF07686
(V-set)
6 VAL A   2
ALA A  24
ARG A  72
VAL A  79
ALA A  98
TYR A 113
None
None
None
None
None
GOL  A 137 (-4.8A)
0.92A 3qxvB-3ln9A:
19.4
3qxvB-3ln9A:
67.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
6 SER A  30
TRP A  34
MET A  36
VAL A  81
ALA A 100
TYR A 120
None
1.49A 3qxvB-3qxuA:
24.1
3qxvB-3qxuA:
96.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
7 SER A  31
TRP A  34
MET A  36
ARG A  74
VAL A  81
ALA A 100
TYR A 120
None
1.43A 3qxvB-3qxuA:
24.1
3qxvB-3qxuA:
96.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
7 VAL A   4
ALA A  26
SER A  30
MET A  36
VAL A  81
ALA A 100
TYR A 120
None
0.89A 3qxvB-3qxuA:
24.1
3qxvB-3qxuA:
96.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
8 VAL A   4
ALA A  26
SER A  31
MET A  36
ARG A  74
VAL A  81
ALA A 100
TYR A 120
None
0.91A 3qxvB-3qxuA:
24.1
3qxvB-3qxuA:
96.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qyc VH DOMAIN OF IGG
MOLECULE


(Homo sapiens)
PF07686
(V-set)
5 VAL A   4
ALA A  26
MET A  36
ARG A  74
VAL A  81
None
0.86A 3qxvB-3qycA:
20.1
3qxvB-3qycA:
61.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r0m LLAMA VHH A12

(Lama glama)
PF07686
(V-set)
5 ALA A  24
SER A  29
MET A  34
VAL A  78
ALA A  94
None
SO4  A 131 (-2.7A)
None
None
None
0.93A 3qxvB-3r0mA:
21.4
3qxvB-3r0mA:
70.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sge HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H   2
ALA H  24
MET H  34
ARG H  74
TYR H 104
None
0.88A 3qxvB-3sgeH:
20.1
3qxvB-3sgeH:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3stb SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
5 ALA A  26
MET A  36
ARG A  73
VAL A  80
ALA A  99
None
0.67A 3qxvB-3stbA:
22.0
3qxvB-3stbA:
70.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b41 ANTIBODY G7

(Lama glama)
PF07686
(V-set)
5 VAL A   2
ALA A  24
MET A  34
VAL A  78
ALA A  97
None
0.93A 3qxvB-4b41A:
18.6
3qxvB-4b41A:
72.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dka SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
6 ALA A  24
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 116
None
0.75A 3qxvB-4dkaA:
22.0
3qxvB-4dkaA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dka SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
6 ALA A  24
SER A  30
MET A  34
ARG A  72
VAL A  79
ALA A  98
None
1.39A 3qxvB-4dkaA:
22.0
3qxvB-4dkaA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eig CA1698 CAMEL
ANTIBODY FRAGMENT


(Lama glama)
PF07686
(V-set)
6 ALA B  24
MET B  34
ARG B  71
VAL B  78
ALA B  97
TYR B 106
None
0.71A 3qxvB-4eigB:
20.1
3qxvB-4eigB:
66.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fhb NB179

(Lama glama)
PF07686
(V-set)
5 MET D  34
ARG D  72
VAL D  79
ALA D  98
TYR D 118
None
0.52A 3qxvB-4fhbD:
21.2
3qxvB-4fhbD:
71.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gft NANOBODY

(Lama glama)
PF07686
(V-set)
5 MET B  36
ARG B  74
VAL B  81
ALA B 100
TYR B 115
None
None
None
None
PCA  B   2 ( 3.9A)
0.35A 3qxvB-4gftB:
22.2
3qxvB-4gftB:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hem ANTI-BASEPLATE
TP901-1 LLAMA VHH 02


(Lama glama)
PF07686
(V-set)
6 ALA E  24
MET E  34
ARG E  72
VAL E  79
ALA E  98
TYR E 112
None
0.68A 3qxvB-4hemE:
22.9
3qxvB-4hemE:
73.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hxa 13D9 FAB HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H   2
MET H  34
ARG H  71
VAL H  78
TYR H 102
None
0.88A 3qxvB-4hxaH:
20.3
3qxvB-4hxaH:
53.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krm NANOBODY/VHH DOMAIN
7D12


(Lama glama)
PF07686
(V-set)
5 ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 113
None
0.71A 3qxvB-4krmB:
23.4
3qxvB-4krmB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krm NANOBODY/VHH DOMAIN
7D12


(Lama glama)
PF07686
(V-set)
5 MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 113
None
0.38A 3qxvB-4krmB:
23.4
3qxvB-4krmB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krm NANOBODY/VHH DOMAIN
7D12


(Lama glama)
PF07686
(V-set)
5 SER B  29
MET B  34
VAL B  79
ALA B  98
TYR B 113
None
0.92A 3qxvB-4krmB:
23.4
3qxvB-4krmB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde CAMELID ANTIBODY
FRAGMENT


(Lama glama)
PF07686
(V-set)
5 VAL B   2
MET B  34
ARG B  71
VAL B  78
TYR B 109
None
0.75A 3qxvB-4ldeB:
19.2
3qxvB-4ldeB:
68.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lhq CAMELID NANOBODY

(Vicugna pacos)
PF07686
(V-set)
5 ALA B  24
SER B  28
MET B  34
ARG B  72
VAL B  79
None
0.90A 3qxvB-4lhqB:
21.6
3qxvB-4lhqB:
63.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nc1 A20.1 VHH

(Lama glama)
PF07686
(V-set)
7 VAL C   9
ALA C  31
MET C  41
ARG C  79
VAL C  86
ALA C 105
TYR C 119
None
0.93A 3qxvB-4nc1C:
22.1
3qxvB-4nc1C:
70.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nc2 B39 VHH

(Lama glama)
PF07686
(V-set)
6 VAL B   2
ALA B  24
MET B  34
ARG B  71
ALA B  97
TYR B 111
None
0.82A 3qxvB-4nc2B:
22.8
3qxvB-4nc2B:
70.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ouo ANTI BLA G 1 SCFV

(Gallus gallus)
PF07686
(V-set)
5 VAL A 116
ALA A 138
MET A 148
ARG A 185
VAL A 192
None
0.92A 3qxvB-4ouoA:
13.3
3qxvB-4ouoA:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION


(Lama glama)
PF07686
(V-set)
6 VAL G   2
MET G  34
ARG G  71
VAL G  78
ALA G  97
TYR G 111
None
0.59A 3qxvB-4p2cG:
18.9
3qxvB-4p2cG:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qlr LLAMA NANOBODY N02
VH DOMAIN


(Lama glama)
PF07686
(V-set)
5 ALA A  24
ARG A  72
VAL A  79
ALA A  98
TYR A 113
None
0.78A 3qxvB-4qlrA:
22.3
3qxvB-4qlrA:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qo1 NB139 NANOBODY
AGAINST THE
DNA-BINDING DOMAIN
OF P53


(Lama glama)
PF07686
(V-set)
6 ALA A  25
MET A  35
ARG A  73
VAL A  80
ALA A  99
TYR A 113
None
0.62A 3qxvB-4qo1A:
21.3
3qxvB-4qo1A:
62.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tvs VHH DOMAIN BS-1

(Vicugna pacos)
PF05609
(LAP1C)
5 ALA a  25
ARG a  73
VAL a  80
ALA a  99
TYR a 117
None
0.80A 3qxvB-4tvsa:
22.3
3qxvB-4tvsa:
72.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w6y NANOBODY NBFEDF9

(Lama glama)
PF07686
(V-set)
6 VAL B   2
ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 118
None
0.96A 3qxvB-4w6yB:
21.0
3qxvB-4w6yB:
69.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4weu ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION


(Lama glama)
PF07686
(V-set)
6 VAL D 802
ALA D 824
MET D 834
ARG D 872
ALA D 898
TYR D 910
None
0.69A 3qxvB-4weuD:
22.1
3qxvB-4weuD:
72.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x8j 12F4 FAB HEAVY CHAIN

(Mus musculus)
no annotation 5 VAL H   2
MET H  34
ARG H  74
VAL H  81
TYR H 104
None
None
None
None
2PE  H 302 ( 4.6A)
0.83A 3qxvB-4x8jH:
15.4
3qxvB-4x8jH:
33.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xt1 NANOBODY 7

(Vicugna pacos)
PF07686
(V-set)
6 VAL C   2
ALA C  24
MET C  34
VAL C  78
ALA C  97
TYR C 107
None
0.94A 3qxvB-4xt1C:
18.9
3qxvB-4xt1C:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yga VHH-1B7

(Vicugna pacos)
PF07686
(V-set)
5 VAL B   3
ALA B  25
ARG B  73
VAL B  80
ALA B  99
None
0.63A 3qxvB-4ygaB:
20.2
3qxvB-4ygaB:
60.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zfo J22.9-XI FAB, HEAVY
CHAIN


(Mus musculus)
no annotation 5 VAL H   2
ALA H  24
MET H  34
ARG H  72
TYR H 109
None
0.90A 3qxvB-4zfoH:
19.0
3qxvB-4zfoH:
37.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2k IG LAMBDA-1 CHAIN V
REGION S43


(Mus musculus)
PF07686
(V-set)
6 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
TYR H 102
None
0.80A 3qxvB-5a2kH:
19.8
3qxvB-5a2kH:
29.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5aum HEAVY CHAIN OF FAB
FRAGMENT


(Rattus)
no annotation 6 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
ALA H  94
None
0.70A 3qxvB-5aumH:
19.7
3qxvB-5aumH:
38.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b6f ANTI-LEUKOTRIENE C4
MONOCLONAL ANTIBODY
IMMUNOGLOBULIN
GAMMA1 HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL B  21
ALA B  43
MET B  53
ARG B  93
VAL B 100
None
0.74A 3qxvB-5b6fB:
19.3
3qxvB-5b6fB:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fwo NANOBODY

(Lama glama)
PF07686
(V-set)
5 VAL A   2
ALA A  24
MET A  34
VAL A  78
TYR A 102
None
0.91A 3qxvB-5fwoA:
21.5
3qxvB-5fwoA:
68.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fwo NANOBODY

(Lama glama)
PF07686
(V-set)
6 VAL A   2
MET A  34
ARG A  71
VAL A  78
ALA A  94
TYR A 102
None
0.60A 3qxvB-5fwoA:
21.5
3qxvB-5fwoA:
68.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gxb NANOBODY

(Vicugna pacos)
PF07686
(V-set)
6 VAL B   2
ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 118
None
1.10A 3qxvB-5gxbB:
20.7
3qxvB-5gxbB:
68.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hm1 LAMA VHH ANTIBODY
2E7


(Lama glama)
PF07686
(V-set)
5 VAL A   2
ALA A  24
VAL A  78
ALA A  94
TYR A 102
None
0.64A 3qxvB-5hm1A:
18.6
3qxvB-5hm1A:
68.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hvf VHH-I83

(Vicugna pacos)
PF07686
(V-set)
5 VAL B   2
ALA B  24
ARG B  70
VAL B  77
TYR B 108
None
0.88A 3qxvB-5hvfB:
18.7
3qxvB-5hvfB:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hvf VHH-I83

(Vicugna pacos)
PF07686
(V-set)
6 VAL B   2
ALA B  24
MET B  34
VAL B  77
ALA B  96
TYR B 108
None
1.01A 3qxvB-5hvfB:
18.7
3qxvB-5hvfB:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iml NANOBODY

(Camelidae)
PF07686
(V-set)
5 MET B  33
ARG B  71
VAL B  78
ALA B  97
TYR B 113
None
0.35A 3qxvB-5imlB:
23.7
3qxvB-5imlB:
75.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j1s VHH DOMAIN BS-2

(Vicugna pacos)
PF07686
(V-set)
5 ALA C  25
MET C  35
ARG C  72
VAL C  79
ALA C  98
None
0.94A 3qxvB-5j1sC:
19.4
3qxvB-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j1s VHH DOMAIN BS-2

(Vicugna pacos)
PF07686
(V-set)
6 VAL C   3
ALA C  25
MET C  35
VAL C  79
ALA C  98
TYR C 112
None
0.74A 3qxvB-5j1sC:
19.4
3qxvB-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j56 VHH SINGLE CHAIN
ANTIBODY V1C7


(Vicugna pacos)
PF07686
(V-set)
5 ALA B  24
ARG B  76
VAL B  83
ALA B 102
TYR B 117
None
0.67A 3qxvB-5j56B:
20.5
3qxvB-5j56B:
67.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ja8 NANOBODY 2

(Lama glama)
PF07686
(V-set)
5 VAL B   3
ALA B  25
ARG B  73
VAL B  80
ALA B  99
None
0.69A 3qxvB-5ja8B:
19.9
3qxvB-5ja8B:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jqh NANOBODY60, NB60

(Lama glama)
no annotation 5 MET D  34
ARG D  71
VAL D  78
ALA D  97
TYR D 108
None
0.88A 3qxvB-5jqhD:
19.1
3qxvB-5jqhD:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kel C2G4 VARIABLE FAB
DOMAIN HEAVY CHAIN


(Homo sapiens)
PF07686
(V-set)
5 ALA H  24
MET H  34
ARG H  71
VAL H  78
TYR H 102
None
0.88A 3qxvB-5kelH:
17.1
3qxvB-5kelH:
51.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lhq CAMELID-DERIVED
ANTIBODY FRAGMENT
NB7


(Vicugna pacos)
PF07686
(V-set)
6 VAL B   2
ALA B  24
ARG B  72
VAL B  79
ALA B  98
TYR B 122
None
0.54A 3qxvB-5lhqB:
21.8
3qxvB-5lhqB:
64.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmj NANOBODY

(Lama glama)
PF07686
(V-set)
6 ALA A  24
MET A  34
ARG A  71
VAL A  78
ALA A  94
TYR A 102
None
0.98A 3qxvB-5lmjA:
20.4
3qxvB-5lmjA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmj NANOBODY

(Lama glama)
PF07686
(V-set)
6 VAL A   2
ALA A  24
ARG A  71
VAL A  78
ALA A  94
TYR A 102
None
0.81A 3qxvB-5lmjA:
20.4
3qxvB-5lmjA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S


(Lama glama)
no annotation 6 VAL C   5
ALA C  27
MET C  37
ARG C  75
ALA C 101
TYR C 117
None
None
None
None
None
ACT  C 202 (-4.4A)
0.74A 3qxvB-5lwfC:
21.1
3qxvB-5lwfC:
68.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S


(Lama glama)
no annotation 6 VAL C   5
MET C  37
ARG C  75
VAL C  82
ALA C 101
TYR C 117
None
None
None
None
None
ACT  C 202 (-4.4A)
0.77A 3qxvB-5lwfC:
21.1
3qxvB-5lwfC:
68.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwn LLAMA NANOBODY
RAISED AGAINST TSSK,
NBK27


(Lama glama)
PF07686
(V-set)
5 VAL N   2
ALA N  24
ARG N  71
VAL N  78
ALA N  97
None
0.85A 3qxvB-5mwnN:
18.2
3qxvB-5mwnN:
67.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwn LLAMA NANOBODY
RAISED AGAINST TSSK,
NBK27


(Lama glama)
PF07686
(V-set)
5 VAL N   2
ALA N  24
MET N  34
VAL N  78
ALA N  97
None
0.86A 3qxvB-5mwnN:
18.2
3qxvB-5mwnN:
67.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o02 NANOBODY (VHH)
NANO-4


(Vicugna pacos)
PF07686
(V-set)
5 VAL C   2
ALA C  24
ARG C  72
ALA C  98
TYR C 113
None
0.93A 3qxvB-5o02C:
21.3
3qxvB-5o02C:
68.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o02 NANOBODY (VHH)
NANO-4


(Vicugna pacos)
PF07686
(V-set)
5 VAL C   2
MET C  34
ARG C  72
ALA C  98
TYR C 113
None
0.59A 3qxvB-5o02C:
21.3
3qxvB-5o02C:
68.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o04 NANOBODY (VHH)
NANO-26


(Vicugna pacos)
PF07686
(V-set)
5 VAL E   2
ALA E  24
ARG E  71
VAL E  78
TYR E 104
None
0.83A 3qxvB-5o04E:
18.5
3qxvB-5o04E:
65.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o0w NB474

(Vicugna pacos)
PF07686
(V-set)
5 VAL E   2
ALA E  24
ARG E  76
VAL E  83
TYR E 126
None
0.81A 3qxvB-5o0wE:
20.4
3qxvB-5o0wE:
64.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o8f NANOBODY NB25

(Lama glama)
no annotation 5 MET L  34
ARG L  72
VAL L  79
ALA L  98
TYR L 114
None
0.53A 3qxvB-5o8fL:
21.6
3qxvB-5o8fL:
68.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS


(Erwinia
amylovora)
no annotation 5 VAL A  33
SER A 136
VAL A 376
ALA A 149
TYR A   6
None
1.01A 3qxvB-5o8rA:
undetectable
3qxvB-5o8rA:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u3j DH511.1 HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H   2
ALA H  24
MET H  34
ARG H  71
ALA H  94
None
0.85A 3qxvB-5u3jH:
19.5
3qxvB-5u3jH:
54.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uk4 ANTI-VESICULAR
STOMATITIS VIRUS N
VHH


(Vicugna pacos)
no annotation 5 VAL p   2
ALA p  24
ARG p  72
ALA p  98
TYR p 114
None
0.98A 3qxvB-5uk4p:
21.2
3qxvB-5uk4p:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uk4 ANTI-VESICULAR
STOMATITIS VIRUS N
VHH


(Vicugna pacos)
no annotation 6 VAL p   2
MET p  34
ARG p  72
VAL p  79
ALA p  98
TYR p 114
None
0.73A 3qxvB-5uk4p:
21.2
3qxvB-5uk4p:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ukb ANTI-VESICULAR
STOMATITIS VIRUS N
VHH


(Vicugna pacos)
no annotation 5 ALA d  24
ARG d  72
VAL d  79
ALA d  98
TYR d 113
None
0.77A 3qxvB-5ukbd:
22.4
3qxvB-5ukbd:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3


(Vicugna pacos)
no annotation 6 VAL B   2
MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 108
None
0.79A 3qxvB-5vxjB:
19.1
3qxvB-5vxjB:
63.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3


(Vicugna pacos)
no annotation 5 ALA B  24
MET B  34
ARG B  73
ALA B  99
TYR B 106
None
0.71A 3qxvB-5vxlB:
20.1
3qxvB-5vxlB:
66.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3


(Vicugna pacos)
no annotation 5 MET B  34
ARG B  73
VAL B  80
ALA B  99
TYR B 106
None
0.57A 3qxvB-5vxlB:
20.1
3qxvB-5vxlB:
66.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w1g CR1-07 FAB HEAVY
CHAIN


(Homo sapiens)
no annotation 5 VAL H   2
ALA H  24
MET H  34
ARG H  72
TYR H 113
None
0.88A 3qxvB-5w1gH:
21.4
3qxvB-5w1gH:
40.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN


(Human
betaherpesvirus
5;
Lama glama)
no annotation 6 VAL A1002
ALA A1024
MET A1034
VAL A1078
ALA A1097
TYR A1107
None
1.00A 3qxvB-5wb1A:
17.9
3qxvB-5wb1A:
15.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wb2 NANOBODY B1

(synthetic
construct)
no annotation 5 ALA D  24
ARG D  72
VAL D  79
ALA D  98
TYR D 118
None
0.96A 3qxvB-5wb2D:
18.6
3qxvB-5wb2D:
68.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN


(Mus musculus)
no annotation 6 VAL A  21
ALA A  43
MET A  53
ARG A  93
VAL A 100
TYR A 124
None
0.85A 3qxvB-5x0tA:
19.9
3qxvB-5x0tA:
31.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy5 -

(-)
no annotation 5 VAL C   2
ALA C  24
MET C  34
ARG C  71
TYR C  97
None
0.89A 3qxvB-5yy5C:
19.3
3qxvB-5yy5C:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6c5w NANOBODY

(Escherichia
coli)
no annotation 5 VAL C   2
MET C  34
VAL C  78
ALA C  97
TYR C 107
None
0.87A 3qxvB-6c5wC:
19.1
3qxvB-6c5wC:
72.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbe NANOBODY VHH R303

(Lama glama)
no annotation 5 ALA A  24
MET A  34
VAL A  79
ALA A  98
TYR A 107
None
0.72A 3qxvB-6dbeA:
20.5
3qxvB-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbe NANOBODY VHH R303

(Lama glama)
no annotation 6 SER A  30
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 107
None
1.21A 3qxvB-6dbeA:
20.5
3qxvB-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbe NANOBODY VHH R303

(Lama glama)
no annotation 5 VAL A   2
ALA A  24
MET A  34
VAL A  79
TYR A 107
None
0.84A 3qxvB-6dbeA:
20.5
3qxvB-6dbeA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ehg HC3NB1

(Lama glama)
no annotation 5 ALA C  24
MET C  34
ARG C  72
VAL C  79
ALA C  98
None
0.74A 3qxvB-6ehgC:
22.3
3qxvB-6ehgC:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ehg HC3NB1

(Lama glama)
no annotation 5 MET C  34
ARG C  72
VAL C  79
ALA C  98
TYR C 112
None
0.50A 3qxvB-6ehgC:
22.3
3qxvB-6ehgC:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ey0 LLAMA NANOBODY NB01

(Lama glama)
no annotation 5 MET E  34
ARG E  71
VAL E  78
ALA E  94
TYR E 102
None
0.78A 3qxvB-6ey0E:
21.3
3qxvB-6ey0E:
56.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6g8r SHORT-CHAIN VARIABLE
FRAGMENT


(Homo sapiens)
no annotation 5 VAL A   2
ALA A  24
MET A  34
ARG A  72
TYR A 108
None
0.99A 3qxvB-6g8rA:
20.2
3qxvB-6g8rA:
62.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gzp NANOBODY

(Lama glama)
no annotation 6 VAL A   2
ALA A  24
MET A  34
ARG A  71
ALA A  94
TYR A 102
None
0.83A 3qxvB-6gzpA:
21.8
3qxvB-6gzpA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL B   2
ALA B  24
MET B  34
ARG B  72
TYR B 110
None
0.96A 3qxvB-8fabB:
21.6
3qxvB-8fabB:
59.52