SIMILAR PATTERNS OF AMINO ACIDS FOR 3QXV_A_MTXA2000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i3u ANTIBODY VHH LAMA
DOMAIN


(Lama glama)
PF07686
(V-set)
6 ALA A  24
ARG A  77
ASN A  79
VAL A  84
ALA A 103
TYR A 118
None
None
None
None
None
CGN  A   1 ( 4.0A)
0.86A 3qxvA-1i3uA:
21.0
3qxvA-1i3uA:
59.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kxt IMMUNOGLOBULIN VHH
FRAGMENT


(Camelus
dromedarius)
PF07686
(V-set)
6 VAL B   2
ALA B  24
MET B  34
ASN B  73
ALA B  94
TYR B 102
None
0.99A 3qxvA-1kxtB:
19.2
3qxvA-1kxtB:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t66 IMMUNOGLOBULIN HEAVY
CHAIN


(Mus musculus)
no annotation 6 VAL H   2
ALA H  24
MET H  34
ARG H  74
VAL H  81
TYR H 107
None
0.86A 3qxvA-1t66H:
19.3
3qxvA-1t66H:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fbj IGA-KAPPA J539 FAB
(HEAVY CHAIN)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
6 VAL H   2
ALA H  24
MET H  34
ARG H  72
ASN H  74
TYR H 107
None
1.13A 3qxvA-2fbjH:
19.9
3qxvA-2fbjH:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x6m HEAVY CHAIN VARIABLE
DOMAIN FROM
DROMEDARY


(Camelus
dromedarius)
PF07686
(V-set)
6 ALA A  24
MET A  34
ASN A  75
VAL A  80
ALA A  99
TYR A 115
None
0.81A 3qxvA-2x6mA:
21.3
3qxvA-2x6mA:
70.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x6m HEAVY CHAIN VARIABLE
DOMAIN FROM
DROMEDARY


(Camelus
dromedarius)
PF07686
(V-set)
6 MET A  34
ARG A  73
ASN A  75
VAL A  80
ALA A  99
TYR A 115
None
1.04A 3qxvA-2x6mA:
21.3
3qxvA-2x6mA:
70.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xa3 LLAMA HEAVY CHAIN
ANTIBODY D7


(Lama glama)
PF07686
(V-set)
6 SER A  29
MET A  34
ASN A  73
VAL A  78
ALA A  94
TYR A 102
SO4  A1114 (-2.7A)
None
None
None
None
None
0.90A 3qxvA-2xa3A:
21.0
3qxvA-2xa3A:
69.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g9a MINIMIZER

(Camelus
dromedarius)
PF07686
(V-set)
6 ALA B  24
MET B  34
ARG B  71
VAL B  78
ALA B  94
TYR B 102
None
0.64A 3qxvA-3g9aB:
19.5
3qxvA-3g9aB:
64.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g9a MINIMIZER

(Camelus
dromedarius)
PF07686
(V-set)
6 VAL B   2
ALA B  24
MET B  34
VAL B  78
ALA B  94
TYR B 102
None
0.87A 3qxvA-3g9aB:
19.5
3qxvA-3g9aB:
64.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k7u ANTIBODY

(Lama glama)
PF07686
(V-set)
6 MET A  34
ARG A  72
ASN A  74
VAL A  79
ALA A  98
TYR A 111
None
0.36A 3qxvA-3k7uA:
22.0
3qxvA-3k7uA:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ln9 IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN B10


(Camelidae)
PF07686
(V-set)
7 VAL A   2
ALA A  24
ARG A  72
ASN A  74
VAL A  79
ALA A  98
TYR A 113
None
None
None
None
None
None
GOL  A 137 (-4.8A)
0.89A 3qxvA-3ln9A:
19.5
3qxvA-3ln9A:
67.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
7 SER A  31
TRP A  34
MET A  36
ARG A  74
VAL A  81
ALA A 100
TYR A 120
None
1.41A 3qxvA-3qxuA:
24.2
3qxvA-3qxuA:
96.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
7 VAL A   4
ALA A  26
SER A  30
MET A  36
VAL A  81
ALA A 100
TYR A 120
None
0.94A 3qxvA-3qxuA:
24.2
3qxvA-3qxuA:
96.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
8 VAL A   4
ALA A  26
SER A  31
MET A  36
ARG A  74
VAL A  81
ALA A 100
TYR A 120
None
0.86A 3qxvA-3qxuA:
24.2
3qxvA-3qxuA:
96.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3stb SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
6 ALA A  26
MET A  36
ARG A  73
ASN A  75
VAL A  80
ALA A  99
None
0.68A 3qxvA-3stbA:
22.1
3qxvA-3stbA:
70.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tpk IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN KW1


(Camelidae)
PF07686
(V-set)
6 VAL A   2
ALA A  24
ASN A  74
VAL A  79
ALA A  98
TYR A 110
None
BEN  A 133 (-3.6A)
None
BEN  A 133 (-4.6A)
BEN  A 133 ( 4.2A)
None
1.30A 3qxvA-3tpkA:
20.3
3qxvA-3tpkA:
64.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u0w FAB HEAVY CHAIN, IG
GAMMA-1 CHAIN C
REGION


(Homo sapiens;
Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
6 VAL H   2
ALA H  24
MET H  34
ARG H  72
ASN H  74
TYR H 102
None
1.05A 3qxvA-3u0wH:
19.8
3qxvA-3u0wH:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dka SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
7 ALA A  24
MET A  34
ARG A  72
ASN A  74
VAL A  79
ALA A  98
TYR A 116
None
0.69A 3qxvA-4dkaA:
22.1
3qxvA-4dkaA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dka SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
7 ALA A  24
SER A  30
MET A  34
ARG A  72
ASN A  74
VAL A  79
ALA A  98
None
1.24A 3qxvA-4dkaA:
22.1
3qxvA-4dkaA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dka SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
7 VAL A   2
ALA A  24
MET A  34
ARG A  72
ASN A  74
VAL A  79
TYR A 116
None
0.91A 3qxvA-4dkaA:
22.1
3qxvA-4dkaA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eig CA1698 CAMEL
ANTIBODY FRAGMENT


(Lama glama)
PF07686
(V-set)
7 ALA B  24
MET B  34
ARG B  71
ASN B  73
VAL B  78
ALA B  97
TYR B 106
None
0.76A 3qxvA-4eigB:
20.2
3qxvA-4eigB:
66.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ej1 NB113 CAMELID
ANTIBODY FRAGMENT


(Lama glama)
PF07686
(V-set)
5 MET C  34
ARG C  72
ASN C  74
VAL C  79
ALA C  98
None
0.34A 3qxvA-4ej1C:
21.6
3qxvA-4ej1C:
74.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fhb NB179

(Lama glama)
PF07686
(V-set)
6 MET D  34
ARG D  72
ASN D  74
VAL D  79
ALA D  98
TYR D 118
None
0.58A 3qxvA-4fhbD:
21.2
3qxvA-4fhbD:
71.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gft NANOBODY

(Lama glama)
PF07686
(V-set)
6 MET B  36
ARG B  74
ASN B  76
VAL B  81
ALA B 100
TYR B 115
None
None
None
None
None
PCA  B   2 ( 3.9A)
0.32A 3qxvA-4gftB:
22.6
3qxvA-4gftB:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4glr ANTI-PTAU HEAVY
CHAIN


(Gallus gallus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H   2
MET H  34
ARG H  71
ASN H  73
VAL H  78
None
0.52A 3qxvA-4glrH:
21.0
3qxvA-4glrH:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hem ANTI-BASEPLATE
TP901-1 LLAMA VHH 02


(Lama glama)
PF07686
(V-set)
7 ALA E  24
MET E  34
ARG E  72
ASN E  74
VAL E  79
ALA E  98
TYR E 112
None
0.62A 3qxvA-4hemE:
23.0
3qxvA-4hemE:
73.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krm NANOBODY/VHH DOMAIN
7D12


(Lama glama)
PF07686
(V-set)
6 MET B  34
ARG B  72
ASN B  74
VAL B  79
ALA B  98
TYR B 113
None
0.43A 3qxvA-4krmB:
23.5
3qxvA-4krmB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lhq CAMELID NANOBODY

(Vicugna pacos)
PF07686
(V-set)
6 ALA B  24
SER B  28
MET B  34
ARG B  72
ASN B  74
VAL B  79
None
0.87A 3qxvA-4lhqB:
21.7
3qxvA-4lhqB:
63.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt NANOBODY 9-8

(Lama glama)
PF07686
(V-set)
6 VAL B   2
ALA B  24
ASN B  77
VAL B  82
ALA B 101
TYR B 110
None
0.92A 3qxvA-4mqtB:
19.0
3qxvA-4mqtB:
64.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1h CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-F11N


(Lama glama)
PF07686
(V-set)
5 MET B  34
ARG B  72
ASN B  74
VAL B  79
ALA B  98
None
0.47A 3qxvA-4n1hB:
21.5
3qxvA-4n1hB:
68.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nc1 A20.1 VHH

(Lama glama)
PF07686
(V-set)
8 VAL C   9
ALA C  31
MET C  41
ARG C  79
ASN C  81
VAL C  86
ALA C 105
TYR C 119
None
0.90A 3qxvA-4nc1C:
21.7
3qxvA-4nc1C:
70.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nc2 B39 VHH

(Lama glama)
PF07686
(V-set)
7 VAL B   2
ALA B  24
MET B  34
ARG B  71
ASN B  73
ALA B  97
TYR B 111
None
0.75A 3qxvA-4nc2B:
22.8
3qxvA-4nc2B:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY


(Homo sapiens)
PF07686
(V-set)
6 VAL B   4
ALA B  26
MET B  36
ARG B  74
ASN B  76
TYR B 108
None
1.09A 3qxvA-4nikB:
20.3
3qxvA-4nikB:
32.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ocr CAP256-VRC26.01
HEAVY CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H   2
MET H  34
ARG H  71
ASN H  73
VAL H  78
None
0.60A 3qxvA-4ocrH:
21.4
3qxvA-4ocrH:
54.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ouo ANTI BLA G 1 SCFV

(Gallus gallus)
PF07686
(V-set)
6 VAL A 116
ALA A 138
MET A 148
ARG A 185
ASN A 187
VAL A 192
None
0.87A 3qxvA-4ouoA:
20.6
3qxvA-4ouoA:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION


(Lama glama)
PF07686
(V-set)
7 VAL G   2
MET G  34
ARG G  71
ASN G  73
VAL G  78
ALA G  97
TYR G 111
None
0.58A 3qxvA-4p2cG:
18.9
3qxvA-4p2cG:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p49 ANTIBODY SCFV B8

(Gallus gallus)
PF07686
(V-set)
6 VAL A 122
ALA A 144
MET A 154
ARG A 193
ASN A 195
VAL A 200
None
0.89A 3qxvA-4p49A:
21.7
3qxvA-4p49A:
51.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qlr LLAMA NANOBODY N02
VH DOMAIN


(Lama glama)
PF07686
(V-set)
6 ALA A  24
ARG A  72
ASN A  74
VAL A  79
ALA A  98
TYR A 113
None
0.73A 3qxvA-4qlrA:
22.2
3qxvA-4qlrA:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qo1 NB139 NANOBODY
AGAINST THE
DNA-BINDING DOMAIN
OF P53


(Lama glama)
PF07686
(V-set)
7 ALA A  25
MET A  35
ARG A  73
ASN A  75
VAL A  80
ALA A  99
TYR A 113
None
0.62A 3qxvA-4qo1A:
21.1
3qxvA-4qo1A:
62.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tvs VHH DOMAIN BS-1

(Vicugna pacos)
PF05609
(LAP1C)
6 ALA a  25
ARG a  73
ASN a  75
VAL a  80
ALA a  99
TYR a 117
None
0.72A 3qxvA-4tvsa:
22.3
3qxvA-4tvsa:
72.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w6y NANOBODY NBFEDF9

(Lama glama)
PF07686
(V-set)
6 MET B  34
ARG B  72
ASN B  74
VAL B  79
ALA B  98
TYR B 118
None
None
SO4  B 201 (-4.0A)
None
None
None
1.47A 3qxvA-4w6yB:
21.1
3qxvA-4w6yB:
69.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w6y NANOBODY NBFEDF9

(Lama glama)
PF07686
(V-set)
7 VAL B   2
ALA B  24
MET B  34
ASN B  74
VAL B  79
ALA B  98
TYR B 118
None
None
None
SO4  B 201 (-4.0A)
None
None
None
0.97A 3qxvA-4w6yB:
21.1
3qxvA-4w6yB:
69.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4weu ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION


(Lama glama)
PF07686
(V-set)
7 VAL D 802
ALA D 824
MET D 834
ARG D 872
ASN D 874
ALA D 898
TYR D 910
None
0.66A 3qxvA-4weuD:
22.1
3qxvA-4weuD:
72.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xt1 NANOBODY 7

(Vicugna pacos)
PF07686
(V-set)
7 VAL C   2
ALA C  24
MET C  34
ASN C  73
VAL C  78
ALA C  97
TYR C 107
None
0.92A 3qxvA-4xt1C:
18.9
3qxvA-4xt1C:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y5v DIABODY 305 VH
DOMAIN


(Homo sapiens)
PF07686
(V-set)
5 VAL A   2
MET A  34
ARG A  72
ASN A  74
VAL A  79
None
0.46A 3qxvA-4y5vA:
20.7
3qxvA-4y5vA:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ybq ANTIBODY FV FRAGMENT
HEAVY CHAIN


(Mus musculus)
PF07686
(V-set)
6 VAL D   3
ALA D  25
MET D  35
ARG D  73
ASN D  75
TYR D 109
None
1.02A 3qxvA-4ybqD:
20.9
3qxvA-4ybqD:
58.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yga VHH-1B7

(Vicugna pacos)
PF07686
(V-set)
6 VAL B   3
ALA B  25
ARG B  73
ASN B  75
VAL B  80
ALA B  99
None
0.75A 3qxvA-4ygaB:
20.2
3qxvA-4ygaB:
60.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2k IG LAMBDA-1 CHAIN V
REGION S43


(Mus musculus)
PF07686
(V-set)
6 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
TYR H 102
None
0.77A 3qxvA-5a2kH:
19.9
3qxvA-5a2kH:
29.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5aum HEAVY CHAIN OF FAB
FRAGMENT


(Rattus)
no annotation 6 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
ALA H  94
None
0.63A 3qxvA-5aumH:
19.7
3qxvA-5aumH:
38.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b3n ANTI-H4K20ME1_SCFV

(Mus musculus)
PF07686
(V-set)
6 VAL A   4
ALA A  26
MET A  36
ARG A  74
ASN A  76
TYR A 112
None
1.09A 3qxvA-5b3nA:
20.6
3qxvA-5b3nA:
58.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bop NANOBODY

(Lama glama)
PF07686
(V-set)
5 MET A  34
ARG A  72
ASN A  74
VAL A  79
ALA A  98
None
0.48A 3qxvA-5bopA:
22.3
3qxvA-5bopA:
69.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5drz HIV ANTIBODY F240
HEAVY CHAIN


(Homo sapiens)
no annotation 5 VAL H   2
MET H  34
ARG H  71
ASN H  73
VAL H  78
None
0.55A 3qxvA-5drzH:
18.8
3qxvA-5drzH:
55.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e1h F8(JOB10) VHH
ANTIBODY


(Vicugna pacos)
PF07686
(V-set)
6 VAL B   2
ALA B  24
MET B  34
ARG B  72
ASN B  74
VAL B  79
None
0.85A 3qxvA-5e1hB:
20.5
3qxvA-5e1hB:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e7f NANOBODY L06

(Camelus
dromedarius)
PF07686
(V-set)
6 VAL A   4
ALA A  26
ARG A  73
ASN A  75
VAL A  80
ALA A  99
None
0.86A 3qxvA-5e7fA:
18.4
3qxvA-5e7fA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e7f NANOBODY L06

(Camelus
dromedarius)
PF07686
(V-set)
6 VAL A   4
MET A  36
ARG A  73
ASN A  75
VAL A  80
ALA A  99
None
0.66A 3qxvA-5e7fA:
18.4
3qxvA-5e7fA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1k NANOBODY MU1053

(Lama glama)
PF07686
(V-set)
5 MET C  34
ARG C  72
ASN C  74
VAL C  79
ALA C  98
None
0.46A 3qxvA-5f1kC:
22.0
3qxvA-5f1kC:
67.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1o NANOBODY MU551

(Lama glama)
PF07686
(V-set)
5 MET B  34
ARG B  72
ASN B  74
VAL B  79
ALA B  98
None
0.37A 3qxvA-5f1oB:
21.1
3qxvA-5f1oB:
65.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fwo NANOBODY

(Lama glama)
PF07686
(V-set)
8 VAL A   2
ALA A  24
MET A  34
ARG A  71
ASN A  73
VAL A  78
ALA A  94
TYR A 102
None
0.81A 3qxvA-5fwoA:
21.4
3qxvA-5fwoA:
68.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gxb NANOBODY

(Vicugna pacos)
PF07686
(V-set)
6 VAL B   2
ALA B  24
MET B  34
ASN B  74
VAL B  79
ALA B  98
None
0.89A 3qxvA-5gxbB:
20.7
3qxvA-5gxbB:
68.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gxb NANOBODY

(Vicugna pacos)
PF07686
(V-set)
6 VAL B   2
ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 118
None
1.17A 3qxvA-5gxbB:
20.7
3qxvA-5gxbB:
68.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hvf VHH-I83

(Vicugna pacos)
PF07686
(V-set)
7 VAL B   2
ALA B  24
ARG B  70
ASN B  72
VAL B  77
ALA B  96
TYR B 108
None
0.91A 3qxvA-5hvfB:
18.7
3qxvA-5hvfB:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hvf VHH-I83

(Vicugna pacos)
PF07686
(V-set)
7 VAL B   2
ALA B  24
MET B  34
ASN B  72
VAL B  77
ALA B  96
TYR B 108
None
1.10A 3qxvA-5hvfB:
18.7
3qxvA-5hvfB:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iml NANOBODY

(Camelidae)
PF07686
(V-set)
6 ALA B  23
MET B  33
ASN B  73
VAL B  78
ALA B  97
TYR B 113
None
0.72A 3qxvA-5imlB:
23.7
3qxvA-5imlB:
75.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iml NANOBODY

(Camelidae)
PF07686
(V-set)
6 MET B  33
ARG B  71
ASN B  73
VAL B  78
ALA B  97
TYR B 113
None
0.30A 3qxvA-5imlB:
23.7
3qxvA-5imlB:
75.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j1s VHH DOMAIN BS-2

(Vicugna pacos)
PF07686
(V-set)
7 ALA C  25
MET C  35
ARG C  72
ASN C  74
VAL C  79
ALA C  98
TYR C 112
None
0.86A 3qxvA-5j1sC:
19.3
3qxvA-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j1s VHH DOMAIN BS-2

(Vicugna pacos)
PF07686
(V-set)
6 VAL C   3
ALA C  25
MET C  35
VAL C  79
ALA C  98
TYR C 112
None
0.71A 3qxvA-5j1sC:
19.3
3qxvA-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j56 VHH SINGLE CHAIN
ANTIBODY V1C7


(Vicugna pacos)
PF07686
(V-set)
6 ALA B  24
ARG B  76
ASN B  78
VAL B  83
ALA B 102
TYR B 117
None
0.91A 3qxvA-5j56B:
20.6
3qxvA-5j56B:
67.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j56 VHH SINGLE CHAIN
ANTIBODY V1C7


(Vicugna pacos)
PF07686
(V-set)
6 VAL B   2
ALA B  24
ARG B  76
ASN B  78
VAL B  83
TYR B 117
None
1.18A 3qxvA-5j56B:
20.6
3qxvA-5j56B:
67.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j57 VHH SINGLE CHAIN
ANTIBODY V5E1


(Vicugna pacos)
PF07686
(V-set)
5 ALA B  24
ARG B  72
ASN B  74
VAL B  79
ALA B  98
None
0.44A 3qxvA-5j57B:
20.5
3qxvA-5j57B:
65.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ja8 NANOBODY 2

(Lama glama)
PF07686
(V-set)
5 ALA B  25
ARG B  73
ASN B  75
VAL B  80
ALA B  99
None
0.54A 3qxvA-5ja8B:
20.2
3qxvA-5ja8B:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ja9 NANOBODY 6

(Lama glama)
PF07686
(V-set)
6 VAL A   3
ALA A  25
MET A  35
ARG A  73
ASN A  75
ALA A  99
None
0.88A 3qxvA-5ja9A:
20.2
3qxvA-5ja9A:
68.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lhq CAMELID-DERIVED
ANTIBODY FRAGMENT
NB7


(Vicugna pacos)
PF07686
(V-set)
7 VAL B   2
ALA B  24
ARG B  72
ASN B  74
VAL B  79
ALA B  98
TYR B 122
None
0.60A 3qxvA-5lhqB:
21.6
3qxvA-5lhqB:
64.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lhr CAMELID-DERIVED
ANTIBODY FRAGMENT
NB22


(Vicugna pacos)
PF07686
(V-set)
6 MET B  34
ARG B  72
ASN B  74
VAL B  79
ALA B  98
TYR B 110
None
1.29A 3qxvA-5lhrB:
20.1
3qxvA-5lhrB:
76.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmj NANOBODY

(Lama glama)
PF07686
(V-set)
7 ALA A  24
MET A  34
ARG A  71
ASN A  73
VAL A  78
ALA A  94
TYR A 102
None
0.94A 3qxvA-5lmjA:
20.2
3qxvA-5lmjA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmj NANOBODY

(Lama glama)
PF07686
(V-set)
7 VAL A   2
ALA A  24
ARG A  71
ASN A  73
VAL A  78
ALA A  94
TYR A 102
None
0.90A 3qxvA-5lmjA:
20.2
3qxvA-5lmjA:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S


(Lama glama)
no annotation 8 VAL C   5
ALA C  27
MET C  37
ARG C  75
ASN C  77
VAL C  82
ALA C 101
TYR C 117
None
None
None
None
None
None
None
ACT  C 202 (-4.4A)
0.74A 3qxvA-5lwfC:
21.4
3qxvA-5lwfC:
68.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nqw 026

(Lama glama)
no annotation 6 VAL C   3
ALA C  25
MET C  35
ARG C  73
ASN C  75
TYR C 112
None
1.10A 3qxvA-5nqwC:
21.1
3qxvA-5nqwC:
44.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o02 NANOBODY (VHH)
NANO-4


(Vicugna pacos)
PF07686
(V-set)
6 VAL C   2
ALA C  24
ARG C  72
ASN C  74
ALA C  98
TYR C 113
None
0.87A 3qxvA-5o02C:
21.2
3qxvA-5o02C:
68.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o02 NANOBODY (VHH)
NANO-4


(Vicugna pacos)
PF07686
(V-set)
6 VAL C   2
MET C  34
ARG C  72
ASN C  74
ALA C  98
TYR C 113
None
0.51A 3qxvA-5o02C:
21.2
3qxvA-5o02C:
68.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o04 NANOBODY (VHH)
NANO-26


(Vicugna pacos)
PF07686
(V-set)
6 VAL E   2
ALA E  24
ARG E  71
ASN E  73
VAL E  78
TYR E 104
None
0.75A 3qxvA-5o04E:
18.6
3qxvA-5o04E:
65.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o8f NANOBODY NB25

(Lama glama)
no annotation 6 MET L  34
ARG L  72
ASN L  74
VAL L  79
ALA L  98
TYR L 114
None
0.64A 3qxvA-5o8fL:
21.6
3qxvA-5o8fL:
68.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovw NANOBODY

(Lama glama)
no annotation 5 ALA G  46
ARG G  94
ASN G  96
VAL G 101
ALA G 120
None
0.53A 3qxvA-5ovwG:
21.5
3qxvA-5ovwG:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uk4 ANTI-VESICULAR
STOMATITIS VIRUS N
VHH


(Vicugna pacos)
no annotation 7 VAL p   2
MET p  34
ARG p  72
ASN p  74
VAL p  79
ALA p  98
TYR p 114
None
0.65A 3qxvA-5uk4p:
21.3
3qxvA-5uk4p:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vaq NB914

(Lama glama)
no annotation 6 ALA B  24
SER B  30
ARG B  72
ASN B  74
VAL B  79
ALA B  98
None
1.02A 3qxvA-5vaqB:
22.8
3qxvA-5vaqB:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3


(Vicugna pacos)
no annotation 6 VAL B   2
MET B  34
ARG B  72
ASN B  74
VAL B  79
ALA B  98
None
0.72A 3qxvA-5vxjB:
19.3
3qxvA-5vxjB:
63.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3


(Vicugna pacos)
no annotation 6 VAL B   2
MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 108
None
0.82A 3qxvA-5vxjB:
19.3
3qxvA-5vxjB:
63.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3


(Vicugna pacos)
no annotation 7 ALA B  24
MET B  34
ARG B  73
ASN B  75
VAL B  80
ALA B  99
TYR B 106
None
0.68A 3qxvA-5vxlB:
20.2
3qxvA-5vxlB:
66.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN


(Human
betaherpesvirus
5;
Lama glama)
no annotation 7 VAL A1002
ALA A1024
MET A1034
ASN A1073
VAL A1078
ALA A1097
TYR A1107
None
0.97A 3qxvA-5wb1A:
18.0
3qxvA-5wb1A:
15.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5y9f HEAVY CHAIN OF FAB
FRAGMENT OF ANTIBODY
28F10


(Mus musculus)
no annotation 6 VAL L   2
ALA L  24
MET L  34
ARG L  72
ASN L  74
TYR L 112
None
0.93A 3qxvA-5y9fL:
20.1
3qxvA-5y9fL:
57.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy5 -

(-)
no annotation 6 VAL C   2
ALA C  24
MET C  34
ARG C  71
ASN C  73
TYR C  97
None
0.92A 3qxvA-5yy5C:
19.4
3qxvA-5yy5C:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6apq ANTI-MARBURGVIRUS
NUCLEOPROTEIN SINGLE
DOMAIN ANTIBODY B


(Lama glama)
no annotation 6 VAL A   2
ALA A  24
ARG A  71
ASN A  73
VAL A  78
TYR A 107
None
CL  A 202 ( 4.0A)
None
None
None
None
1.19A 3qxvA-6apqA:
19.2
3qxvA-6apqA:
66.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9w -

(-)
no annotation 6 VAL B   2
ALA B  24
MET B  34
ASN B  74
VAL B  79
TYR B 114
None
1.17A 3qxvA-6c9wB:
21.1
3qxvA-6c9wB:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6d11 1450 ANTIBODY, HEAVY
CHAIN


(Homo sapiens)
no annotation 5 VAL A   2
MET A  34
ARG A  71
ASN A  73
VAL A  78
None
0.51A 3qxvA-6d11A:
20.4
3qxvA-6d11A:
44.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbe NANOBODY VHH R303

(Lama glama)
no annotation 6 SER A  30
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 107
None
1.26A 3qxvA-6dbeA:
20.6
3qxvA-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbe NANOBODY VHH R303

(Lama glama)
no annotation 6 VAL A   2
ALA A  24
MET A  34
ASN A  74
ALA A  98
TYR A 107
None
1.13A 3qxvA-6dbeA:
20.6
3qxvA-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbe NANOBODY VHH R303

(Lama glama)
no annotation 6 VAL A   2
ALA A  24
MET A  34
VAL A  79
ALA A  98
TYR A 107
None
0.81A 3qxvA-6dbeA:
20.6
3qxvA-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbe NANOBODY VHH R303

(Lama glama)
no annotation 6 VAL A   2
SER A  30
MET A  34
VAL A  79
ALA A  98
TYR A 107
None
1.01A 3qxvA-6dbeA:
20.6
3qxvA-6dbeA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ehg HC3NB1

(Lama glama)
no annotation 7 ALA C  24
MET C  34
ARG C  72
ASN C  74
VAL C  79
ALA C  98
TYR C 112
None
0.71A 3qxvA-6ehgC:
22.2
3qxvA-6ehgC:
57.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gzp NANOBODY

(Lama glama)
no annotation 7 VAL A   2
ALA A  24
MET A  34
ARG A  71
ASN A  73
ALA A  94
TYR A 102
None
0.71A 3qxvA-6gzpA:
21.6
3qxvA-6gzpA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
6 VAL B   2
ALA B  24
MET B  34
ARG B  72
ASN B  74
TYR B 110
None
1.02A 3qxvA-8fabB:
21.7
3qxvA-8fabB:
59.52