SIMILAR PATTERNS OF AMINO ACIDS FOR 3QXT_B_MTXB2000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g6v ANTIBODY HEAVY CHAIN

(Camelus
dromedarius)
PF07686
(V-set)
6 VAL K 802
LEU K 804
ALA K 824
MET K 834
VAL K 877
TYR K 915
None
0.69A 3qxtB-1g6vK:
20.8
3qxtB-1g6vK:
70.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i3u ANTIBODY VHH LAMA
DOMAIN


(Lama glama)
PF07686
(V-set)
6 LEU A   4
ALA A  24
ARG A  77
VAL A  84
ALA A 103
TYR A 118
None
None
None
None
None
CGN  A   1 ( 4.0A)
0.73A 3qxtB-1i3uA:
20.9
3qxtB-1i3uA:
60.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kxt IMMUNOGLOBULIN VHH
FRAGMENT


(Camelus
dromedarius)
PF07686
(V-set)
6 VAL B   2
LEU B   4
ALA B  24
MET B  34
ALA B  94
TYR B 102
None
0.91A 3qxtB-1kxtB:
19.9
3qxtB-1kxtB:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sjx IMMUNOGLOBULIN VH
DOMAIN


(Lama glama)
PF07686
(V-set)
6 VAL A 802
LEU A 804
MET A 834
VAL A 878
ALA A 897
TYR A 908
None
None
MPD  A8001 ( 3.5A)
None
None
None
0.87A 3qxtB-1sjxA:
21.0
3qxtB-1sjxA:
69.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t66 IMMUNOGLOBULIN HEAVY
CHAIN


(Mus musculus)
no annotation 6 LEU H   4
ALA H  24
MET H  34
ARG H  74
VAL H  81
TYR H 107
None
0.68A 3qxtB-1t66H:
19.7
3qxtB-1t66H:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t66 IMMUNOGLOBULIN HEAVY
CHAIN


(Mus musculus)
no annotation 6 VAL H   2
LEU H   4
MET H  34
ARG H  74
VAL H  81
TYR H 107
None
0.69A 3qxtB-1t66H:
19.7
3qxtB-1t66H:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x6m HEAVY CHAIN VARIABLE
DOMAIN FROM
DROMEDARY


(Camelus
dromedarius)
PF07686
(V-set)
6 LEU A   4
ALA A  24
MET A  34
VAL A  80
ALA A  99
TYR A 115
None
0.55A 3qxtB-2x6mA:
21.5
3qxtB-2x6mA:
69.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x6m HEAVY CHAIN VARIABLE
DOMAIN FROM
DROMEDARY


(Camelus
dromedarius)
PF07686
(V-set)
6 LEU A   4
MET A  34
ARG A  73
VAL A  80
ALA A  99
TYR A 115
None
0.91A 3qxtB-2x6mA:
21.5
3qxtB-2x6mA:
69.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xa3 LLAMA HEAVY CHAIN
ANTIBODY D7


(Lama glama)
PF07686
(V-set)
6 LEU A   4
SER A  29
MET A  34
VAL A  78
ALA A  94
TYR A 102
None
SO4  A1114 (-2.7A)
None
None
None
None
0.78A 3qxtB-2xa3A:
21.2
3qxtB-2xa3A:
69.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eak NBBCII10-FGLA

(Camelus
dromedarius)
PF07686
(V-set)
6 VAL A   2
LEU A   4
ALA A  24
ARG A  75
ALA A 101
TYR A 117
None
0.76A 3qxtB-3eakA:
21.9
3qxtB-3eakA:
67.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g9a MINIMIZER

(Camelus
dromedarius)
PF07686
(V-set)
8 VAL B   2
LEU B   4
ALA B  24
MET B  34
ARG B  71
VAL B  78
ALA B  94
TYR B 102
None
0.71A 3qxtB-3g9aB:
20.2
3qxtB-3g9aB:
66.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3if1 IMMUNOGLOBULIN HEAVY
CHAIN (IGG2A)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
6 VAL B   2
LEU B   4
ALA B  24
MET B  34
ARG B  71
TYR B 102
None
0.67A 3qxtB-3if1B:
20.1
3qxtB-3if1B:
32.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k7u ANTIBODY

(Lama glama)
PF07686
(V-set)
6 LEU A   4
ALA A  24
ARG A  72
VAL A  79
ALA A  98
TYR A 111
None
0.69A 3qxtB-3k7uA:
22.5
3qxtB-3k7uA:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k7u ANTIBODY

(Lama glama)
PF07686
(V-set)
6 LEU A   4
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 111
None
0.33A 3qxtB-3k7uA:
22.5
3qxtB-3k7uA:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
8 VAL A   4
LEU A   6
ALA A  26
SER A  30
MET A  36
VAL A  81
ALA A 100
TYR A 120
None
0.86A 3qxtB-3qxuA:
24.9
3qxtB-3qxuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
9 VAL A   4
LEU A   6
ALA A  26
SER A  31
MET A  36
ARG A  74
VAL A  81
ALA A 100
TYR A 120
None
0.78A 3qxtB-3qxuA:
24.9
3qxtB-3qxuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qyc VH DOMAIN OF IGG
MOLECULE


(Homo sapiens)
PF07686
(V-set)
6 VAL A   4
LEU A   6
ALA A  26
MET A  36
ARG A  74
VAL A  81
None
0.57A 3qxtB-3qycA:
20.2
3qxtB-3qycA:
62.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r0m LLAMA VHH A12

(Lama glama)
PF07686
(V-set)
6 LEU A   4
ALA A  24
SER A  29
MET A  34
VAL A  78
ALA A  94
None
None
SO4  A 131 (-2.7A)
None
None
None
0.83A 3qxtB-3r0mA:
21.3
3qxtB-3r0mA:
70.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3stb SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
6 LEU A   6
ALA A  26
MET A  36
ARG A  73
VAL A  80
ALA A  99
None
0.52A 3qxtB-3stbA:
22.3
3qxtB-3stbA:
71.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3stb SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
6 VAL A   4
LEU A   6
ALA A  26
MET A  36
ARG A  73
VAL A  80
None
0.78A 3qxtB-3stbA:
22.3
3qxtB-3stbA:
71.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tpk IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN KW1


(Camelidae)
PF07686
(V-set)
6 VAL A   2
LEU A   4
ALA A  24
VAL A  79
ALA A  98
TYR A 110
None
BEN  A 133 (-4.7A)
BEN  A 133 (-3.6A)
BEN  A 133 (-4.6A)
BEN  A 133 ( 4.2A)
None
0.78A 3qxtB-3tpkA:
21.0
3qxtB-3tpkA:
64.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dka SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
7 LEU A   4
ALA A  24
SER A  30
MET A  34
ARG A  72
VAL A  79
ALA A  98
None
1.25A 3qxtB-4dkaA:
22.4
3qxtB-4dkaA:
74.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dka SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
8 VAL A   2
LEU A   4
ALA A  24
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 116
None
0.72A 3qxtB-4dkaA:
22.4
3qxtB-4dkaA:
74.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eig CA1698 CAMEL
ANTIBODY FRAGMENT


(Lama glama)
PF07686
(V-set)
7 LEU B   4
ALA B  24
MET B  34
ARG B  71
VAL B  78
ALA B  97
TYR B 106
None
0.63A 3qxtB-4eigB:
20.5
3qxtB-4eigB:
67.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ej1 NB113 CAMELID
ANTIBODY FRAGMENT


(Lama glama)
PF07686
(V-set)
6 LEU C   4
ALA C  24
MET C  34
ARG C  72
VAL C  79
ALA C  98
None
0.59A 3qxtB-4ej1C:
21.9
3qxtB-4ej1C:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f58 HEAVY CHAIN OF FAB
OF A NEUTRALIZING
ANTIBODY L3


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
6 VAL H   2
LEU H   4
ALA H  24
MET H  34
ARG H  71
VAL H  78
None
0.85A 3qxtB-4f58H:
20.5
3qxtB-4f58H:
61.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fhb NB179

(Lama glama)
PF07686
(V-set)
6 LEU D   4
MET D  34
ARG D  72
VAL D  79
ALA D  98
TYR D 118
None
0.59A 3qxtB-4fhbD:
21.5
3qxtB-4fhbD:
72.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gft NANOBODY

(Lama glama)
PF07686
(V-set)
6 LEU B   5
MET B  36
ARG B  74
VAL B  81
ALA B 100
TYR B 115
None
None
None
None
None
PCA  B   2 ( 3.9A)
0.34A 3qxtB-4gftB:
22.5
3qxtB-4gftB:
66.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hem ANTI-BASEPLATE
TP901-1 LLAMA VHH 02


(Lama glama)
PF07686
(V-set)
7 LEU E   4
ALA E  24
MET E  34
ARG E  72
VAL E  79
ALA E  98
TYR E 112
None
0.54A 3qxtB-4hemE:
23.4
3qxtB-4hemE:
74.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hlz FAB C179 HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
6 VAL G   2
LEU G   4
MET G  34
ARG G  71
VAL G  78
TYR G 102
None
0.67A 3qxtB-4hlzG:
19.5
3qxtB-4hlzG:
53.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krm NANOBODY/VHH DOMAIN
7D12


(Lama glama)
PF07686
(V-set)
7 LEU B   4
ALA B  24
MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 113
None
0.58A 3qxtB-4krmB:
23.6
3qxtB-4krmB:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krm NANOBODY/VHH DOMAIN
7D12


(Lama glama)
PF07686
(V-set)
7 LEU B   4
SER B  29
MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 113
None
0.91A 3qxtB-4krmB:
23.6
3qxtB-4krmB:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde CAMELID ANTIBODY
FRAGMENT


(Lama glama)
PF07686
(V-set)
6 VAL B   2
LEU B   4
MET B  34
ARG B  71
VAL B  78
TYR B 109
None
0.80A 3qxtB-4ldeB:
19.6
3qxtB-4ldeB:
68.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lhq CAMELID NANOBODY

(Vicugna pacos)
PF07686
(V-set)
6 LEU B   4
ALA B  24
SER B  28
MET B  34
ARG B  72
VAL B  79
None
0.76A 3qxtB-4lhqB:
22.0
3qxtB-4lhqB:
64.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt NANOBODY 9-8

(Lama glama)
PF07686
(V-set)
6 VAL B   2
LEU B   4
ALA B  24
VAL B  82
ALA B 101
TYR B 110
None
0.69A 3qxtB-4mqtB:
19.1
3qxtB-4mqtB:
63.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1h CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-F11N


(Lama glama)
PF07686
(V-set)
6 LEU B   4
ALA B  24
MET B  34
ARG B  72
VAL B  79
ALA B  98
None
0.68A 3qxtB-4n1hB:
21.6
3qxtB-4n1hB:
70.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nc1 A20.1 VHH

(Lama glama)
PF07686
(V-set)
8 VAL C   9
LEU C  11
ALA C  31
MET C  41
ARG C  79
VAL C  86
ALA C 105
TYR C 119
None
0.87A 3qxtB-4nc1C:
22.3
3qxtB-4nc1C:
70.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nc2 B39 VHH

(Lama glama)
PF07686
(V-set)
6 LEU B   4
ALA B  24
MET B  34
ARG B  71
ALA B  97
TYR B 111
None
0.61A 3qxtB-4nc2B:
23.7
3qxtB-4nc2B:
71.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nc2 B39 VHH

(Lama glama)
PF07686
(V-set)
6 VAL B   2
LEU B   4
MET B  34
ARG B  71
ALA B  97
TYR B 111
None
0.55A 3qxtB-4nc2B:
23.7
3qxtB-4nc2B:
71.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION


(Lama glama)
PF07686
(V-set)
7 VAL G   2
LEU G   4
MET G  34
ARG G  71
VAL G  78
ALA G  97
TYR G 111
None
0.63A 3qxtB-4p2cG:
19.4
3qxtB-4p2cG:
71.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qlr LLAMA NANOBODY N02
VH DOMAIN


(Lama glama)
PF07686
(V-set)
6 LEU A   4
ALA A  24
ARG A  72
VAL A  79
ALA A  98
TYR A 113
None
0.64A 3qxtB-4qlrA:
22.9
3qxtB-4qlrA:
70.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qlr LLAMA NANOBODY N02
VH DOMAIN


(Lama glama)
PF07686
(V-set)
6 VAL A   2
LEU A   4
ALA A  24
ARG A  72
ALA A  98
TYR A 113
None
0.87A 3qxtB-4qlrA:
22.9
3qxtB-4qlrA:
70.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qo1 NB139 NANOBODY
AGAINST THE
DNA-BINDING DOMAIN
OF P53


(Lama glama)
PF07686
(V-set)
7 LEU A   5
ALA A  25
MET A  35
ARG A  73
VAL A  80
ALA A  99
TYR A 113
None
0.50A 3qxtB-4qo1A:
21.2
3qxtB-4qo1A:
63.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tvs VHH DOMAIN BS-1

(Vicugna pacos)
PF05609
(LAP1C)
6 LEU a   5
ALA a  25
ARG a  73
VAL a  80
ALA a  99
TYR a 117
None
0.65A 3qxtB-4tvsa:
22.8
3qxtB-4tvsa:
73.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w6y NANOBODY NBFEDF9

(Lama glama)
PF07686
(V-set)
7 VAL B   2
LEU B   4
ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 118
None
0.86A 3qxtB-4w6yB:
21.5
3qxtB-4w6yB:
70.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4weu ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION


(Lama glama)
PF07686
(V-set)
7 VAL D 802
LEU D 804
ALA D 824
MET D 834
ARG D 872
ALA D 898
TYR D 910
None
0.61A 3qxtB-4weuD:
22.5
3qxtB-4weuD:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x8j 12F4 FAB HEAVY CHAIN

(Mus musculus)
no annotation 6 VAL H   2
LEU H   4
MET H  34
ARG H  74
VAL H  81
TYR H 104
None
None
None
None
None
2PE  H 302 ( 4.6A)
0.65A 3qxtB-4x8jH:
15.8
3qxtB-4x8jH:
34.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xt1 NANOBODY 7

(Vicugna pacos)
PF07686
(V-set)
7 VAL C   2
LEU C   4
ALA C  24
MET C  34
VAL C  78
ALA C  97
TYR C 107
None
0.88A 3qxtB-4xt1C:
19.5
3qxtB-4xt1C:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydk HEAVY CHAIN OF
ANTIBODY
C38-VRC16.01


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
6 VAL H   2
LEU H   4
ALA H  24
MET H  34
ARG H  71
VAL H  78
None
0.89A 3qxtB-4ydkH:
20.4
3qxtB-4ydkH:
35.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2k IG LAMBDA-1 CHAIN V
REGION S43


(Mus musculus)
PF07686
(V-set)
7 VAL H   2
LEU H   4
ALA H  24
MET H  34
ARG H  71
VAL H  78
TYR H 102
None
0.74A 3qxtB-5a2kH:
20.2
3qxtB-5a2kH:
29.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5aum HEAVY CHAIN OF FAB
FRAGMENT


(Rattus)
no annotation 6 LEU H   4
ALA H  24
MET H  34
ARG H  71
VAL H  78
ALA H  94
None
0.63A 3qxtB-5aumH:
20.1
3qxtB-5aumH:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5aum HEAVY CHAIN OF FAB
FRAGMENT


(Rattus)
no annotation 6 VAL H   2
LEU H   4
MET H  34
ARG H  71
VAL H  78
ALA H  94
None
0.60A 3qxtB-5aumH:
20.1
3qxtB-5aumH:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e7f NANOBODY L06

(Camelus
dromedarius)
PF07686
(V-set)
6 VAL A   4
LEU A   6
ALA A  26
ARG A  73
VAL A  80
ALA A  99
None
0.87A 3qxtB-5e7fA:
19.0
3qxtB-5e7fA:
67.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e7f NANOBODY L06

(Camelus
dromedarius)
PF07686
(V-set)
6 VAL A   4
LEU A   6
MET A  36
ARG A  73
VAL A  80
ALA A  99
None
0.66A 3qxtB-5e7fA:
19.0
3qxtB-5e7fA:
67.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fwo NANOBODY

(Lama glama)
PF07686
(V-set)
8 VAL A   2
LEU A   4
ALA A  24
MET A  34
ARG A  71
VAL A  78
ALA A  94
TYR A 102
None
0.79A 3qxtB-5fwoA:
21.9
3qxtB-5fwoA:
68.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gxb NANOBODY

(Vicugna pacos)
PF07686
(V-set)
7 VAL B   2
LEU B   4
ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 118
None
1.03A 3qxtB-5gxbB:
21.1
3qxtB-5gxbB:
69.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hm1 LAMA VHH ANTIBODY
2E7


(Lama glama)
PF07686
(V-set)
6 VAL A   2
LEU A   4
ALA A  24
VAL A  78
ALA A  94
TYR A 102
None
0.74A 3qxtB-5hm1A:
18.7
3qxtB-5hm1A:
68.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hvf VHH-I83

(Vicugna pacos)
PF07686
(V-set)
7 VAL B   2
LEU B   4
ALA B  24
ARG B  70
VAL B  77
ALA B  96
TYR B 108
None
0.79A 3qxtB-5hvfB:
18.7
3qxtB-5hvfB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hvf VHH-I83

(Vicugna pacos)
PF07686
(V-set)
7 VAL B   2
LEU B   4
ALA B  24
MET B  34
VAL B  77
ALA B  96
TYR B 108
None
0.94A 3qxtB-5hvfB:
18.7
3qxtB-5hvfB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iml NANOBODY

(Camelidae)
PF07686
(V-set)
7 LEU B   3
ALA B  23
MET B  33
ARG B  71
VAL B  78
ALA B  97
TYR B 113
None
0.64A 3qxtB-5imlB:
24.0
3qxtB-5imlB:
76.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j1s VHH DOMAIN BS-2

(Vicugna pacos)
PF07686
(V-set)
8 VAL C   3
LEU C   5
ALA C  25
MET C  35
ARG C  72
VAL C  79
ALA C  98
TYR C 112
None
0.81A 3qxtB-5j1sC:
19.9
3qxtB-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j56 VHH SINGLE CHAIN
ANTIBODY V1C7


(Vicugna pacos)
PF07686
(V-set)
7 VAL B   2
LEU B   4
ALA B  24
ARG B  76
VAL B  83
ALA B 102
TYR B 117
None
0.81A 3qxtB-5j56B:
21.3
3qxtB-5j56B:
67.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jqh NANOBODY60, NB60

(Lama glama)
no annotation 6 VAL D   2
LEU D   4
MET D  34
ARG D  71
VAL D  78
ALA D  97
None
0.84A 3qxtB-5jqhD:
19.5
3qxtB-5jqhD:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lhq CAMELID-DERIVED
ANTIBODY FRAGMENT
NB7


(Vicugna pacos)
PF07686
(V-set)
7 VAL B   2
LEU B   4
ALA B  24
ARG B  72
VAL B  79
ALA B  98
TYR B 122
None
0.61A 3qxtB-5lhqB:
22.0
3qxtB-5lhqB:
65.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lhr CAMELID-DERIVED
ANTIBODY FRAGMENT
NB22


(Vicugna pacos)
PF07686
(V-set)
6 LEU B   4
ALA B  24
MET B  34
ARG B  72
VAL B  79
ALA B  98
None
0.83A 3qxtB-5lhrB:
20.0
3qxtB-5lhrB:
76.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmj NANOBODY

(Lama glama)
PF07686
(V-set)
7 LEU A   4
ALA A  24
MET A  34
ARG A  71
VAL A  78
ALA A  94
TYR A 102
None
0.98A 3qxtB-5lmjA:
20.5
3qxtB-5lmjA:
74.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S


(Lama glama)
no annotation 7 LEU C   7
ALA C  27
MET C  37
ARG C  75
VAL C  82
ALA C 101
TYR C 117
None
None
None
None
None
None
ACT  C 202 (-4.4A)
0.48A 3qxtB-5lwfC:
21.7
3qxtB-5lwfC:
69.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5m13 SYNTHETIC NANOBODY
L2_C06 (A-MBP#2)


(synthetic
construct)
no annotation 6 VAL B   2
LEU B   4
ALA B  24
VAL B  79
ALA B  98
TYR B 114
None
0.75A 3qxtB-5m13B:
22.5
3qxtB-5m13B:
64.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o02 NANOBODY (VHH)
NANO-4


(Vicugna pacos)
PF07686
(V-set)
6 VAL C   2
LEU C   4
MET C  34
ARG C  72
ALA C  98
TYR C 113
None
0.57A 3qxtB-5o02C:
21.6
3qxtB-5o02C:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o03 NANOBODY (VHH)
NANO-32


(Norwalk virus)
PF07686
(V-set)
6 LEU C   4
ALA C  24
ARG C  72
VAL C  79
ALA C  98
TYR C 124
None
0.85A 3qxtB-5o03C:
20.9
3qxtB-5o03C:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o04 NANOBODY (VHH)
NANO-26


(Vicugna pacos)
PF07686
(V-set)
6 VAL E   2
LEU E   4
ALA E  24
ARG E  71
VAL E  78
TYR E 104
None
0.87A 3qxtB-5o04E:
18.9
3qxtB-5o04E:
65.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o05 NANOBODY (VHH)
NANO-42


(Vicugna pacos)
PF07686
(V-set)
6 VAL C   2
LEU C   4
ALA C  24
SER C  29
VAL C  78
TYR C 109
None
0.81A 3qxtB-5o05C:
17.1
3qxtB-5o05C:
66.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o8f NANOBODY NB25

(Lama glama)
no annotation 6 LEU L   4
ALA L  24
MET L  34
VAL L  79
ALA L  98
TYR L 114
None
0.79A 3qxtB-5o8fL:
22.0
3qxtB-5o8fL:
69.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o8f NANOBODY NB25

(Lama glama)
no annotation 6 LEU L   4
MET L  34
ARG L  72
VAL L  79
ALA L  98
TYR L 114
None
0.61A 3qxtB-5o8fL:
22.0
3qxtB-5o8fL:
69.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ocl ANTI-VGLUT NANOBODY

(Lama glama)
PF07686
(V-set)
6 VAL B   4
LEU B   6
ALA B  26
VAL B  81
ALA B 100
TYR B 115
None
0.74A 3qxtB-5oclB:
20.1
3qxtB-5oclB:
73.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td8 NANOBODY

(Vicugna pacos)
PF07686
(V-set)
6 VAL E   3
LEU E   5
ALA E  25
VAL E  80
ALA E  99
TYR E 117
None
0.78A 3qxtB-5td8E:
18.7
3qxtB-5td8E:
68.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uk4 ANTI-VESICULAR
STOMATITIS VIRUS N
VHH


(Vicugna pacos)
no annotation 6 LEU p   4
ALA p  24
MET p  34
ARG p  72
ALA p  98
TYR p 114
None
0.76A 3qxtB-5uk4p:
21.8
3qxtB-5uk4p:
70.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uk4 ANTI-VESICULAR
STOMATITIS VIRUS N
VHH


(Vicugna pacos)
no annotation 7 VAL p   2
LEU p   4
MET p  34
ARG p  72
VAL p  79
ALA p  98
TYR p 114
None
0.72A 3qxtB-5uk4p:
21.8
3qxtB-5uk4p:
70.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ukb ANTI-VESICULAR
STOMATITIS VIRUS N
VHH


(Vicugna pacos)
no annotation 6 LEU d   4
ALA d  24
ARG d  72
VAL d  79
ALA d  98
TYR d 113
None
0.66A 3qxtB-5ukbd:
22.6
3qxtB-5ukbd:
72.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ukb ANTI-VESICULAR
STOMATITIS VIRUS N
VHH


(Vicugna pacos)
no annotation 6 LEU d   4
ARG d  30
ARG d  72
VAL d  79
ALA d  98
TYR d 113
None
0.78A 3qxtB-5ukbd:
22.6
3qxtB-5ukbd:
72.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ukb ANTI-VESICULAR
STOMATITIS VIRUS N
VHH


(Vicugna pacos)
no annotation 6 VAL d   2
LEU d   4
ALA d  24
VAL d  79
ALA d  98
TYR d 113
None
0.89A 3qxtB-5ukbd:
22.6
3qxtB-5ukbd:
72.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vaq NB914

(Lama glama)
no annotation 6 LEU B   4
ALA B  24
SER B  30
ARG B  72
VAL B  79
ALA B  98
None
0.79A 3qxtB-5vaqB:
22.9
3qxtB-5vaqB:
76.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vgj VRC38.01 FAB HEAVY
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
6 VAL H   2
LEU H   4
ALA H  24
MET H  34
ARG H  71
VAL H  78
None
0.56A 3qxtB-5vgjH:
19.4
3qxtB-5vgjH:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3


(Vicugna pacos)
no annotation 7 VAL B   2
LEU B   4
ALA B  24
ARG B  72
VAL B  79
ALA B  98
TYR B 108
None
0.99A 3qxtB-5vxjB:
19.6
3qxtB-5vxjB:
63.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3


(Vicugna pacos)
no annotation 7 VAL B   2
LEU B   4
MET B  34
ARG B  72
VAL B  79
ALA B  98
TYR B 108
None
0.69A 3qxtB-5vxjB:
19.6
3qxtB-5vxjB:
63.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3


(Vicugna pacos)
no annotation 7 LEU B   4
ALA B  24
MET B  34
ARG B  73
VAL B  80
ALA B  99
TYR B 106
None
0.59A 3qxtB-5vxlB:
20.7
3qxtB-5vxlB:
64.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN


(Human
betaherpesvirus
5;
Lama glama)
no annotation 7 VAL A1002
LEU A1004
ALA A1024
MET A1034
VAL A1078
ALA A1097
TYR A1107
None
0.94A 3qxtB-5wb1A:
18.4
3qxtB-5wb1A:
14.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wb2 NANOBODY B1

(synthetic
construct)
no annotation 6 LEU D   4
ALA D  24
ARG D  72
VAL D  79
ALA D  98
TYR D 118
None
0.82A 3qxtB-5wb2D:
19.0
3qxtB-5wb2D:
69.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN


(Mus musculus)
no annotation 6 LEU A  23
ALA A  43
MET A  53
ARG A  93
VAL A 100
TYR A 124
None
0.69A 3qxtB-5x0tA:
20.1
3qxtB-5x0tA:
31.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN


(Mus musculus)
no annotation 6 VAL A  21
LEU A  23
MET A  53
ARG A  93
VAL A 100
TYR A 124
None
0.72A 3qxtB-5x0tA:
20.1
3qxtB-5x0tA:
31.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xjm FABH

(Mus musculus)
no annotation 6 VAL H   2
LEU H   4
ALA H  24
MET H  34
ARG H  72
TYR H 109
None
0.86A 3qxtB-5xjmH:
21.4
3qxtB-5xjmH:
59.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6d11 1450 ANTIBODY, HEAVY
CHAIN


(Homo sapiens)
no annotation 6 VAL A   2
LEU A   4
ALA A  24
MET A  34
ARG A  71
VAL A  78
None
0.82A 3qxtB-6d11A:
20.5
3qxtB-6d11A:
53.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbe NANOBODY VHH R303

(Lama glama)
no annotation 7 LEU A   4
SER A  30
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 107
None
1.17A 3qxtB-6dbeA:
20.8
3qxtB-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbe NANOBODY VHH R303

(Lama glama)
no annotation 7 VAL A   2
LEU A   4
ALA A  24
MET A  34
VAL A  79
ALA A  98
TYR A 107
None
0.66A 3qxtB-6dbeA:
20.8
3qxtB-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbe NANOBODY VHH R303

(Lama glama)
no annotation 7 VAL A   2
LEU A   4
SER A  30
MET A  34
VAL A  79
ALA A  98
TYR A 107
None
0.93A 3qxtB-6dbeA:
20.8
3qxtB-6dbeA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ehg HC3NB1

(Lama glama)
no annotation 6 LEU C   4
ALA C  24
MET C  34
ARG C  72
VAL C  79
ALA C  98
None
0.59A 3qxtB-6ehgC:
22.5
3qxtB-6ehgC:
74.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ehg HC3NB1

(Lama glama)
no annotation 6 LEU C   4
MET C  34
ARG C  72
VAL C  79
ALA C  98
TYR C 112
None
0.61A 3qxtB-6ehgC:
22.5
3qxtB-6ehgC:
74.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ehg HC3NB1

(Lama glama)
no annotation 6 VAL C   2
LEU C   4
ALA C  24
MET C  34
ARG C  72
VAL C  79
None
0.81A 3qxtB-6ehgC:
22.5
3qxtB-6ehgC:
74.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ehg HC3NB1

(Lama glama)
no annotation 6 VAL C   2
LEU C   4
MET C  34
ARG C  72
VAL C  79
TYR C 112
None
0.86A 3qxtB-6ehgC:
22.5
3qxtB-6ehgC:
74.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gzp NANOBODY

(Lama glama)
no annotation 7 VAL A   2
LEU A   4
ALA A  24
MET A  34
ARG A  71
ALA A  94
TYR A 102
None
0.68A 3qxtB-6gzpA:
22.0
3qxtB-6gzpA:
undetectable