SIMILAR PATTERNS OF AMINO ACIDS FOR 3QXT_A_MTXA2000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g6v ANTIBODY HEAVY CHAIN

(Camelus
dromedarius)
PF07686
(V-set)
5 VAL K 802
ALA K 824
MET K 834
ASN K 875
VAL K 877
None
0.84A 3qxtA-1g6vK:
20.4
3qxtA-1g6vK:
70.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i3u ANTIBODY VHH LAMA
DOMAIN


(Lama glama)
PF07686
(V-set)
5 ALA A  24
ARG A  77
ASN A  82
VAL A  84
ALA A 103
None
0.80A 3qxtA-1i3uA:
20.9
3qxtA-1i3uA:
60.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ind IGG1-LAMBDA CHA255
FAB (HEAVY CHAIN)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H   2
ALA H  24
MET H  34
ARG H  72
ASN H  77
None
0.93A 3qxtA-1indH:
19.6
3qxtA-1indH:
36.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pz5 HEAVY CHAIN OF FAB
(SYA/J6)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL B   2
ALA B  24
MET B  34
ARG B  71
VAL B  78
None
0.83A 3qxtA-1pz5B:
20.2
3qxtA-1pz5B:
52.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x6m HEAVY CHAIN VARIABLE
DOMAIN FROM
DROMEDARY


(Camelus
dromedarius)
PF07686
(V-set)
5 ALA A  24
MET A  34
ASN A  78
VAL A  80
ALA A  99
None
0.65A 3qxtA-2x6mA:
21.5
3qxtA-2x6mA:
69.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g9a MINIMIZER

(Camelus
dromedarius)
PF07686
(V-set)
6 VAL B   2
ALA B  24
MET B  34
ARG B  71
ASN B  76
ALA B  94
None
0.90A 3qxtA-3g9aB:
20.0
3qxtA-3g9aB:
66.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g9a MINIMIZER

(Camelus
dromedarius)
PF07686
(V-set)
6 VAL B   2
ALA B  24
MET B  34
ARG B  71
VAL B  78
ALA B  94
None
0.77A 3qxtA-3g9aB:
20.0
3qxtA-3g9aB:
66.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k80 ANTIBODY

(Lama glama)
PF07686
(V-set)
5 ALA A  24
MET A  34
ARG A  72
ASN A  77
VAL A  79
None
0.93A 3qxtA-3k80A:
22.2
3qxtA-3k80A:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k80 ANTIBODY

(Lama glama)
PF07686
(V-set)
5 VAL A   2
ALA A  24
ARG A  72
ASN A  77
VAL A  79
None
1.06A 3qxtA-3k80A:
22.2
3qxtA-3k80A:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
6 VAL A   4
ALA A  26
MET A  36
ARG A  74
VAL A  81
ALA A 100
None
0.81A 3qxtA-3qxuA:
25.6
3qxtA-3qxuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
6 VAL A   4
ALA A  26
SER A  30
MET A  36
VAL A  81
ALA A 100
None
0.93A 3qxtA-3qxuA:
25.6
3qxtA-3qxuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
6 VAL A   4
ALA A  26
SER A  30
SER A  31
MET A  36
ALA A 100
None
1.01A 3qxtA-3qxuA:
25.6
3qxtA-3qxuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxu ANTI-METHOTREXATE
CDR1-3 GRAFT


(Lama glama)
PF07686
(V-set)
6 VAL A   4
ALA A  26
SER A  31
MET A  36
ARG A  74
ALA A 100
None
0.70A 3qxtA-3qxuA:
25.6
3qxtA-3qxuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qyc VH DOMAIN OF IGG
MOLECULE


(Homo sapiens)
PF07686
(V-set)
5 VAL A   4
ALA A  26
MET A  36
ARG A  74
VAL A  81
None
0.69A 3qxtA-3qycA:
19.8
3qxtA-3qycA:
62.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r0m LLAMA VHH A12

(Lama glama)
PF07686
(V-set)
5 ALA A  24
SER A  29
MET A  34
VAL A  78
ALA A  94
None
SO4  A 131 (-2.7A)
None
None
None
0.83A 3qxtA-3r0mA:
21.2
3qxtA-3r0mA:
70.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3stb SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
6 ALA A  26
MET A  36
ARG A  73
ASN A  78
VAL A  80
ALA A  99
None
0.79A 3qxtA-3stbA:
22.2
3qxtA-3stbA:
71.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3stb SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
5 VAL A   4
ALA A  26
ARG A  73
ASN A  78
VAL A  80
None
1.00A 3qxtA-3stbA:
22.2
3qxtA-3stbA:
71.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tpk IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN KW1


(Camelidae)
PF07686
(V-set)
5 VAL A   2
ALA A  24
ASN A  77
VAL A  79
ALA A  98
None
BEN  A 133 (-3.6A)
BEN  A 133 (-3.3A)
BEN  A 133 (-4.6A)
BEN  A 133 ( 4.2A)
0.76A 3qxtA-3tpkA:
20.9
3qxtA-3tpkA:
64.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b41 ANTIBODY G7

(Lama glama)
PF07686
(V-set)
5 VAL A   2
ALA A  24
MET A  34
VAL A  78
ALA A  97
None
0.92A 3qxtA-4b41A:
19.0
3qxtA-4b41A:
72.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dka SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
6 ALA A  24
SER A  30
MET A  34
ARG A  72
VAL A  79
ALA A  98
None
1.47A 3qxtA-4dkaA:
22.6
3qxtA-4dkaA:
74.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dka SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
6 VAL A   2
ALA A  24
MET A  34
ARG A  72
ASN A  77
ALA A  98
None
0.95A 3qxtA-4dkaA:
22.6
3qxtA-4dkaA:
74.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dka SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
6 VAL A   2
ALA A  24
MET A  34
ARG A  72
VAL A  79
ALA A  98
None
0.83A 3qxtA-4dkaA:
22.6
3qxtA-4dkaA:
74.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eig CA1698 CAMEL
ANTIBODY FRAGMENT


(Lama glama)
PF07686
(V-set)
5 ALA B  24
MET B  34
ARG B  71
VAL B  78
ALA B  97
None
0.68A 3qxtA-4eigB:
20.5
3qxtA-4eigB:
67.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f58 HEAVY CHAIN OF FAB
OF A NEUTRALIZING
ANTIBODY L3


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
5 ALA H  24
MET H  34
ARG H  71
ASN H  76
VAL H  78
None
1.04A 3qxtA-4f58H:
20.3
3qxtA-4f58H:
61.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f58 HEAVY CHAIN OF FAB
OF A NEUTRALIZING
ANTIBODY L3


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
None
1.00A 3qxtA-4f58H:
20.3
3qxtA-4f58H:
61.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hem ANTI-BASEPLATE
TP901-1 LLAMA VHH 02


(Lama glama)
PF07686
(V-set)
5 ALA E  24
MET E  34
ARG E  72
VAL E  79
ALA E  98
None
0.57A 3qxtA-4hemE:
23.2
3qxtA-4hemE:
74.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kfz ANTI-LMO2 VH

(Homo sapiens)
PF07686
(V-set)
5 ALA C  24
SER C  28
MET C  34
ARG C  72
ASN C  77
None
0.88A 3qxtA-4kfzC:
20.4
3qxtA-4kfzC:
62.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kml NANOBODY

(Lama glama)
PF07686
(V-set)
5 VAL B   2
ALA B  24
MET B  34
ARG B  72
ASN B  77
None
0.91A 3qxtA-4kmlB:
23.0
3qxtA-4kmlB:
67.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krm NANOBODY/VHH DOMAIN
7D12


(Lama glama)
PF07686
(V-set)
6 ALA B  24
MET B  34
ARG B  72
ASN B  77
VAL B  79
ALA B  98
None
0.82A 3qxtA-4krmB:
23.3
3qxtA-4krmB:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krm NANOBODY/VHH DOMAIN
7D12


(Lama glama)
PF07686
(V-set)
5 SER B  29
MET B  34
ARG B  72
VAL B  79
ALA B  98
None
0.47A 3qxtA-4krmB:
23.3
3qxtA-4krmB:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kvn HUMAN IGG HEAVY
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
6 VAL H   2
ALA H  24
SER H  30
ARG H  72
ASN H  77
VAL H  79
None
0.85A 3qxtA-4kvnH:
19.6
3qxtA-4kvnH:
42.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lhj CAMELID ANTIBODY

(Vicugna pacos)
PF07686
(V-set)
PF07705
(CARDB)
5 SER B  27
ARG B 102
MET B  34
VAL B  78
ALA B  97
None
0.97A 3qxtA-4lhjB:
18.1
3qxtA-4lhjB:
68.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lhq CAMELID NANOBODY

(Vicugna pacos)
PF07686
(V-set)
5 ALA B  24
SER B  28
MET B  34
ARG B  72
VAL B  79
None
0.91A 3qxtA-4lhqB:
21.6
3qxtA-4lhqB:
64.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nc1 A20.1 VHH

(Lama glama)
PF07686
(V-set)
7 VAL C   9
ALA C  31
MET C  41
ARG C  79
ASN C  84
VAL C  86
ALA C 105
None
1.01A 3qxtA-4nc1C:
21.9
3qxtA-4nc1C:
70.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nc2 B39 VHH

(Lama glama)
PF07686
(V-set)
5 ALA B  24
MET B  34
ARG B  71
ASN B  76
ALA B  97
None
0.95A 3qxtA-4nc2B:
23.1
3qxtA-4nc2B:
71.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4orz SINGLE DOMAIN
ANTIBODY SDAB19


(Lama glama)
PF07686
(V-set)
5 ALA C  26
MET C  36
ARG C  73
ASN C  78
VAL C  80
None
0.96A 3qxtA-4orzC:
20.7
3qxtA-4orzC:
65.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION


(Lama glama)
PF07686
(V-set)
5 MET G  34
ARG G  71
ASN G  76
VAL G  78
ALA G  97
None
0.76A 3qxtA-4p2cG:
19.2
3qxtA-4p2cG:
71.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2c NANOBODY 1,
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION


(Lama glama)
PF07686
(V-set)
5 VAL G   2
MET G  34
ARG G  71
VAL G  78
ALA G  97
None
0.68A 3qxtA-4p2cG:
19.2
3qxtA-4p2cG:
71.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4py8 ANTIBODY 3.1 HEAVY
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL I   2
ALA I  24
ARG I  72
ASN I  77
VAL I  79
None
0.72A 3qxtA-4py8I:
21.0
3qxtA-4py8I:
65.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qo1 NB139 NANOBODY
AGAINST THE
DNA-BINDING DOMAIN
OF P53


(Lama glama)
PF07686
(V-set)
6 ALA A  25
MET A  35
ARG A  73
ASN A  78
VAL A  80
ALA A  99
None
0.73A 3qxtA-4qo1A:
20.8
3qxtA-4qo1A:
63.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4s10 GELSOLIN NANOBODY

(Lama glama)
PF07686
(V-set)
5 VAL A   2
ALA A  24
ASN A  77
VAL A  79
ALA A  98
None
0.70A 3qxtA-4s10A:
22.1
3qxtA-4s10A:
71.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4s10 GELSOLIN NANOBODY

(Lama glama)
PF07686
(V-set)
5 VAL A   2
MET A  34
ASN A  77
VAL A  79
ALA A  98
None
1.03A 3qxtA-4s10A:
22.1
3qxtA-4s10A:
71.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tvs VHH DOMAIN BS-1

(Vicugna pacos)
PF05609
(LAP1C)
5 ALA a  25
ARG a  73
ASN a  78
VAL a  80
ALA a  99
None
0.76A 3qxtA-4tvsa:
22.8
3qxtA-4tvsa:
73.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w6y NANOBODY NBFEDF9

(Lama glama)
PF07686
(V-set)
6 VAL B   2
ALA B  24
MET B  34
ASN B  77
VAL B  79
ALA B  98
None
0.93A 3qxtA-4w6yB:
21.5
3qxtA-4w6yB:
70.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x7f NANO-25 NANOBODY

(Vicugna pacos)
PF07686
(V-set)
5 VAL C   2
ALA C  24
MET C  34
ASN C  76
VAL C  78
None
0.93A 3qxtA-4x7fC:
18.9
3qxtA-4x7fC:
63.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xt1 NANOBODY 7

(Vicugna pacos)
PF07686
(V-set)
5 VAL C   2
ALA C  24
MET C  34
VAL C  78
ALA C  97
None
0.91A 3qxtA-4xt1C:
19.3
3qxtA-4xt1C:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydk HEAVY CHAIN OF
ANTIBODY
C38-VRC16.01


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
None
1.03A 3qxtA-4ydkH:
20.0
3qxtA-4ydkH:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yga VHH-1B7

(Vicugna pacos)
PF07686
(V-set)
5 ALA B  25
ARG B  73
ASN B  78
VAL B  80
ALA B  99
None
0.66A 3qxtA-4ygaB:
20.4
3qxtA-4ygaB:
61.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zfo J22.9-XI FAB, HEAVY
CHAIN


(Mus musculus)
no annotation 5 VAL H   2
ALA H  24
MET H  34
ARG H  72
ASN H  77
None
0.98A 3qxtA-4zfoH:
18.7
3qxtA-4zfoH:
37.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2k IG LAMBDA-1 CHAIN V
REGION S43


(Mus musculus)
PF07686
(V-set)
5 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
None
0.88A 3qxtA-5a2kH:
19.9
3qxtA-5a2kH:
29.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5aum HEAVY CHAIN OF FAB
FRAGMENT


(Rattus)
no annotation 5 ALA H  24
MET H  34
ARG H  71
VAL H  78
ALA H  94
None
0.64A 3qxtA-5aumH:
19.7
3qxtA-5aumH:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5aum HEAVY CHAIN OF FAB
FRAGMENT


(Rattus)
no annotation 5 VAL H   2
MET H  34
ARG H  71
VAL H  78
ALA H  94
None
0.54A 3qxtA-5aumH:
19.7
3qxtA-5aumH:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b6f ANTI-LEUKOTRIENE C4
MONOCLONAL ANTIBODY
IMMUNOGLOBULIN
GAMMA1 HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 ALA B  43
MET B  53
ARG B  93
ASN B  98
VAL B 100
None
0.57A 3qxtA-5b6fB:
19.3
3qxtA-5b6fB:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e1h F8(JOB10) VHH
ANTIBODY


(Vicugna pacos)
PF07686
(V-set)
5 VAL B   2
ALA B  24
MET B  34
ARG B  72
VAL B  79
None
0.94A 3qxtA-5e1hB:
20.6
3qxtA-5e1hB:
69.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e7f NANOBODY L06

(Camelus
dromedarius)
PF07686
(V-set)
5 ALA A  26
ARG A  73
ASN A  78
VAL A  80
ALA A  99
None
0.95A 3qxtA-5e7fA:
18.9
3qxtA-5e7fA:
67.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e7f NANOBODY L06

(Camelus
dromedarius)
PF07686
(V-set)
5 MET A  36
ARG A  73
ASN A  78
VAL A  80
ALA A  99
None
0.63A 3qxtA-5e7fA:
18.9
3qxtA-5e7fA:
67.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e7f NANOBODY L06

(Camelus
dromedarius)
PF07686
(V-set)
5 VAL A   4
ALA A  26
ARG A  73
VAL A  80
ALA A  99
None
0.98A 3qxtA-5e7fA:
18.9
3qxtA-5e7fA:
67.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e7f NANOBODY L06

(Camelus
dromedarius)
PF07686
(V-set)
5 VAL A   4
MET A  36
ARG A  73
VAL A  80
ALA A  99
None
0.76A 3qxtA-5e7fA:
18.9
3qxtA-5e7fA:
67.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1k NANOBODY MU1053

(Lama glama)
PF07686
(V-set)
5 MET C  34
ARG C  72
ASN C  77
VAL C  79
ALA C  98
None
0.32A 3qxtA-5f1kC:
22.3
3qxtA-5f1kC:
68.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fwo NANOBODY

(Lama glama)
PF07686
(V-set)
5 ALA A  24
MET A  34
ARG A  71
ASN A  76
ALA A  94
None
0.92A 3qxtA-5fwoA:
21.7
3qxtA-5fwoA:
68.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fwo NANOBODY

(Lama glama)
PF07686
(V-set)
6 VAL A   2
ALA A  24
MET A  34
ARG A  71
VAL A  78
ALA A  94
None
0.92A 3qxtA-5fwoA:
21.7
3qxtA-5fwoA:
68.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gxb NANOBODY

(Vicugna pacos)
PF07686
(V-set)
6 VAL B   2
ALA B  24
MET B  34
ASN B  77
VAL B  79
ALA B  98
None
0.92A 3qxtA-5gxbB:
21.0
3qxtA-5gxbB:
69.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hvf VHH-I83

(Vicugna pacos)
PF07686
(V-set)
5 VAL B   2
ALA B  24
ARG B  70
VAL B  77
ALA B  96
None
0.88A 3qxtA-5hvfB:
18.7
3qxtA-5hvfB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hvf VHH-I83

(Vicugna pacos)
PF07686
(V-set)
5 VAL B   2
ALA B  24
MET B  34
VAL B  77
ALA B  96
None
1.03A 3qxtA-5hvfB:
18.7
3qxtA-5hvfB:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iml NANOBODY

(Camelidae)
PF07686
(V-set)
6 ALA B  23
MET B  33
ARG B  71
ASN B  76
VAL B  78
ALA B  97
None
0.84A 3qxtA-5imlB:
23.7
3qxtA-5imlB:
76.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j1s VHH DOMAIN BS-2

(Vicugna pacos)
PF07686
(V-set)
7 VAL C   3
ALA C  25
MET C  35
ARG C  72
ASN C  77
VAL C  79
ALA C  98
None
0.96A 3qxtA-5j1sC:
19.6
3qxtA-5j1sC:
66.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j56 VHH SINGLE CHAIN
ANTIBODY V1C7


(Vicugna pacos)
PF07686
(V-set)
6 VAL B   2
ALA B  24
ARG B  76
ASN B  81
VAL B  83
ALA B 102
None
0.90A 3qxtA-5j56B:
21.3
3qxtA-5j56B:
67.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ja8 NANOBODY 2

(Lama glama)
PF07686
(V-set)
5 ALA B  25
ARG B  73
ASN B  78
VAL B  80
ALA B  99
None
0.56A 3qxtA-5ja8B:
20.6
3qxtA-5ja8B:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ja9 NANOBODY 6

(Lama glama)
PF07686
(V-set)
5 ALA A  25
MET A  35
ARG A  73
ASN A  78
ALA A  99
None
1.01A 3qxtA-5ja9A:
20.4
3qxtA-5ja9A:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jqh NANOBODY60, NB60

(Lama glama)
no annotation 5 VAL D   2
MET D  34
ARG D  71
VAL D  78
ALA D  97
None
0.97A 3qxtA-5jqhD:
19.5
3qxtA-5jqhD:
70.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kel C2G4 VARIABLE FAB
DOMAIN HEAVY CHAIN


(Homo sapiens)
PF07686
(V-set)
5 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
None
1.01A 3qxtA-5kelH:
17.3
3qxtA-5kelH:
51.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lhq CAMELID-DERIVED
ANTIBODY FRAGMENT
NB7


(Vicugna pacos)
PF07686
(V-set)
5 ALA B  24
ARG B  72
ASN B  77
VAL B  79
ALA B  98
None
0.54A 3qxtA-5lhqB:
21.8
3qxtA-5lhqB:
65.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lhq CAMELID-DERIVED
ANTIBODY FRAGMENT
NB7


(Vicugna pacos)
PF07686
(V-set)
5 VAL B   2
ARG B  72
ASN B  77
VAL B  79
ALA B  98
None
0.66A 3qxtA-5lhqB:
21.8
3qxtA-5lhqB:
65.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lhr CAMELID-DERIVED
ANTIBODY FRAGMENT
NB22


(Vicugna pacos)
PF07686
(V-set)
5 MET B  34
ARG B  72
ASN B  77
VAL B  79
ALA B  98
None
0.87A 3qxtA-5lhrB:
19.9
3qxtA-5lhrB:
76.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmj NANOBODY

(Lama glama)
PF07686
(V-set)
6 ALA A  24
MET A  34
ARG A  71
ASN A  76
VAL A  78
ALA A  94
None
0.95A 3qxtA-5lmjA:
20.3
3qxtA-5lmjA:
74.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmj NANOBODY

(Lama glama)
PF07686
(V-set)
6 VAL A   2
ALA A  24
ARG A  71
ASN A  76
VAL A  78
ALA A  94
None
0.89A 3qxtA-5lmjA:
20.3
3qxtA-5lmjA:
74.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S


(Lama glama)
no annotation 6 ALA C  27
MET C  37
ARG C  75
ASN C  80
VAL C  82
ALA C 101
None
0.57A 3qxtA-5lwfC:
21.3
3qxtA-5lwfC:
69.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S


(Lama glama)
no annotation 6 VAL C   5
MET C  37
ARG C  75
ASN C  80
VAL C  82
ALA C 101
None
0.71A 3qxtA-5lwfC:
21.3
3qxtA-5lwfC:
69.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwn LLAMA NANOBODY
RAISED AGAINST TSSK,
NBK27


(Lama glama)
PF07686
(V-set)
5 VAL N   2
ALA N  24
ARG N  71
VAL N  78
ALA N  97
None
0.91A 3qxtA-5mwnN:
18.4
3qxtA-5mwnN:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwn LLAMA NANOBODY
RAISED AGAINST TSSK,
NBK27


(Lama glama)
PF07686
(V-set)
5 VAL N   2
ALA N  24
MET N  34
VAL N  78
ALA N  97
None
0.94A 3qxtA-5mwnN:
18.4
3qxtA-5mwnN:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o05 NANOBODY (VHH)
NANO-42


(Vicugna pacos)
PF07686
(V-set)
5 VAL C   2
ALA C  24
SER C  29
ASN C  76
VAL C  78
None
0.82A 3qxtA-5o05C:
17.3
3qxtA-5o05C:
66.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o8f NANOBODY NB25

(Lama glama)
no annotation 5 MET L  34
ARG L  72
ASN L  77
VAL L  79
ALA L  98
None
0.91A 3qxtA-5o8fL:
21.5
3qxtA-5o8fL:
69.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovw NANOBODY

(Lama glama)
no annotation 5 ALA G  46
ARG G  94
ASN G  99
VAL G 101
ALA G 120
None
0.48A 3qxtA-5ovwG:
21.6
3qxtA-5ovwG:
60.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uk4 ANTI-VESICULAR
STOMATITIS VIRUS N
VHH


(Vicugna pacos)
no annotation 5 ALA p  24
MET p  34
ARG p  72
ASN p  77
ALA p  98
None
1.01A 3qxtA-5uk4p:
21.7
3qxtA-5uk4p:
70.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uk4 ANTI-VESICULAR
STOMATITIS VIRUS N
VHH


(Vicugna pacos)
no annotation 5 MET p  34
ARG p  72
ASN p  77
VAL p  79
ALA p  98
None
0.75A 3qxtA-5uk4p:
21.7
3qxtA-5uk4p:
70.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uk4 ANTI-VESICULAR
STOMATITIS VIRUS N
VHH


(Vicugna pacos)
no annotation 5 VAL p   2
MET p  34
ARG p  72
VAL p  79
ALA p  98
None
0.80A 3qxtA-5uk4p:
21.7
3qxtA-5uk4p:
70.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ukb ANTI-VESICULAR
STOMATITIS VIRUS N
VHH


(Vicugna pacos)
no annotation 6 ALA d  24
ARG d  30
ARG d  72
ASN d  77
VAL d  79
ALA d  98
None
1.05A 3qxtA-5ukbd:
22.4
3qxtA-5ukbd:
72.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vaq NB914

(Lama glama)
no annotation 6 ALA B  24
SER B  30
ARG B  72
ASN B  77
VAL B  79
ALA B  98
None
1.05A 3qxtA-5vaqB:
22.9
3qxtA-5vaqB:
76.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vgj VRC38.01 FAB HEAVY
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
6 VAL H   2
ALA H  24
MET H  34
ARG H  71
ASN H  76
VAL H  78
None
0.64A 3qxtA-5vgjH:
19.3
3qxtA-5vgjH:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vnw NB.B201

(synthetic
construct)
no annotation 5 VAL C   2
ALA C  24
MET C  34
ASN C  76
VAL C  78
None
0.94A 3qxtA-5vnwC:
21.0
3qxtA-5vnwC:
75.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3


(Vicugna pacos)
no annotation 5 MET B  34
ARG B  72
ASN B  77
VAL B  79
ALA B  98
None
0.76A 3qxtA-5vxjB:
19.3
3qxtA-5vxjB:
63.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxj SINGLE-DOMAIN
ANTIBODY JMK-E3


(Vicugna pacos)
no annotation 5 VAL B   2
MET B  34
ARG B  72
VAL B  79
ALA B  98
None
0.71A 3qxtA-5vxjB:
19.3
3qxtA-5vxjB:
63.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxk SINGLE-DOMAIN
ANTIBODY JMK-H2


(Vicugna pacos)
no annotation 5 ALA B  24
ARG B  72
ASN B  77
VAL B  79
ALA B  98
None
0.45A 3qxtA-5vxkB:
21.5
3qxtA-5vxkB:
67.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxl SINGLE-DOMAIN
ANTIBODY JPS-G3


(Vicugna pacos)
no annotation 5 ALA B  24
MET B  34
ARG B  73
VAL B  80
ALA B  99
None
0.68A 3qxtA-5vxlB:
20.4
3qxtA-5vxlB:
64.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN


(Human
betaherpesvirus
5;
Lama glama)
no annotation 5 VAL A1002
ALA A1024
MET A1034
VAL A1078
ALA A1097
None
0.96A 3qxtA-5wb1A:
18.3
3qxtA-5wb1A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbe NANOBODY VHH R303

(Lama glama)
no annotation 6 VAL A   2
ALA A  24
MET A  34
ASN A  77
VAL A  79
ALA A  98
None
0.75A 3qxtA-6dbeA:
20.7
3qxtA-6dbeA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ehg HC3NB1

(Lama glama)
no annotation 5 ALA C  24
MET C  34
ARG C  72
VAL C  79
ALA C  98
None
0.65A 3qxtA-6ehgC:
22.2
3qxtA-6ehgC:
74.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ehg HC3NB1

(Lama glama)
no annotation 5 VAL C   2
ALA C  24
MET C  34
ARG C  72
VAL C  79
None
0.89A 3qxtA-6ehgC:
22.2
3qxtA-6ehgC:
74.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gzp NANOBODY

(Lama glama)
no annotation 5 ALA A  24
MET A  34
ARG A  71
ASN A  76
ALA A  94
None
0.88A 3qxtA-6gzpA:
21.8
3qxtA-6gzpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gzp NANOBODY

(Lama glama)
no annotation 5 VAL A   2
ALA A  24
MET A  34
ARG A  71
ALA A  94
None
0.83A 3qxtA-6gzpA:
21.8
3qxtA-6gzpA:
undetectable