SIMILAR PATTERNS OF AMINO ACIDS FOR 3QT0_A_486A4_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dt2 EXFOLIATIVE TOXIN B

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		4 LYS A  14
GLN A 207
ILE A 212
LEU A 152
 None
 1.41A 3qt0A-1dt2A:
0.0		 3qt0A-1dt2A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hm6 ANNEXIN 1

(Sus scrofa) 		PF00191
(Annexin) 		4 LYS A 185
GLN A 177
ILE A 260
LEU A 225
 None
 1.44A 3qt0A-1hm6A:
0.1		 3qt0A-1hm6A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT

(Bos taurus) 		PF04699
(P16-Arc) 		4 LYS G  93
GLN G 127
ILE G 110
LEU G  59
 None
 1.36A 3qt0A-1u2vG:
undetectable		 3qt0A-1u2vG:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3n GLUTATHIONE
S-TRANSFERASE THETA
1

(Homo sapiens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 LYS A 216
GLN A 208
ILE A  19
LEU A   7
 None
 1.17A 3qt0A-2c3nA:
0.9		 3qt0A-2c3nA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2li6 SWI/SNF
CHROMATIN-REMODELING
COMPLEX SUBUNIT SWI1

(Saccharomyces
cerevisiae) 		PF01388
(ARID) 		4 LYS A 110
GLN A 106
ILE A  28
LEU A  54
 None
 1.22A 3qt0A-2li6A:
undetectable		 3qt0A-2li6A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		4 LYS A 250
GLN A 242
ILE A 208
LEU A 202
 None
 0.96A 3qt0A-2pg6A:
0.0		 3qt0A-2pg6A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE

(Synechocystis
sp. PCC 6803) 		PF00293
(NUDIX)
PF01467
(CTP_transf_like) 		4 LYS A  98
GLN A  93
ILE A  11
LEU A  39
 None
 0.89A 3qt0A-2qjoA:
0.0		 3qt0A-2qjoA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3

(Mus musculus) 		PF03747
(ADP_ribosyl_GH) 		4 LYS A   1
GLN A 187
ILE A 309
LEU A 285
 None
 1.10A 3qt0A-2qtyA:
0.0		 3qt0A-2qtyA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN

(Staphylococcus
aureus) 		PF01276
(OKR_DC_1)
PF03711
(OKR_DC_1_C) 		4 LYS A  68
GLN A  65
ILE A  59
LEU A  77
 None
 1.46A 3qt0A-2x3lA:
0.0		 3qt0A-2x3lA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 AP-2 COMPLEX SUBUNIT
BETA

(Homo sapiens) 		PF01602
(Adaptin_N) 		4 LYS B 318
GLN B 311
ILE B 564
LEU B 267
 None
 1.30A 3qt0A-2xa7B:
0.0		 3qt0A-2xa7B:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		no annotation 4 LYS C 378
GLN C 417
ILE C 282
LEU C 294
 None
 1.31A 3qt0A-3amjC:
0.0		 3qt0A-3amjC:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezh NITRATE/NITRITE
SENSOR PROTEIN NARX

(Escherichia
coli) 		PF13675
(PilJ) 		4 LYS A  49
GLN A 103
ILE A 111
LEU A  73
 None
 1.36A 3qt0A-3ezhA:
undetectable		 3qt0A-3ezhA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezi NITRATE/NITRITE
SENSOR PROTEIN NARX

(Escherichia
coli) 		PF13675
(PilJ) 		4 LYS A  49
GLN A 103
ILE A 111
LEU A  73
 None
 1.12A 3qt0A-3eziA:
undetectable		 3qt0A-3eziA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h08 RNH (RIBONUCLEASE H)

(Chlorobaculum
tepidum) 		PF00075
(RNase_H) 		4 LYS A  84
GLN A 106
ILE A  53
LEU A  67
 None
 1.38A 3qt0A-3h08A:
undetectable		 3qt0A-3h08A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqv RCL1 PROTEIN

(Kluyveromyces
lactis) 		PF01137
(RTC)
PF05189
(RTC_insert) 		4 LYS A 142
GLN A 291
ILE A 311
LEU A 182
 None
 1.12A 3qt0A-3pqvA:
undetectable		 3qt0A-3pqvA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugm TAL EFFECTOR
AVRBS3/PTHA

(Xanthomonas
oryzae) 		PF03377
(TAL_effector) 		4 LYS A 711
GLN A 746
ILE A 738
LEU A 721
 None
 1.48A 3qt0A-3ugmA:
undetectable		 3qt0A-3ugmA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usw FLAGELLAR MOTOR
SWITCH PROTEIN

(Helicobacter
pylori) 		PF01706
(FliG_C)
PF14841
(FliG_M) 		4 LYS A 330
GLN A 325
ILE A 251
LEU A 263
 None
 1.35A 3qt0A-3uswA:
undetectable		 3qt0A-3uswA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi3 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 LYS A 559
GLN A 599
ILE A 565
LEU A 520
 None
 1.21A 3qt0A-3vi3A:
undetectable		 3qt0A-3vi3A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3r ENOLASE

(Bacillus
subtilis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LYS A 357
GLN A 388
ILE A 377
LEU A 134
 None
 1.47A 3qt0A-4a3rA:
undetectable		 3qt0A-4a3rA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aur LEOA

(Escherichia
coli) 		PF00350
(Dynamin_N) 		4 LYS A 203
GLN A 219
ILE A 260
LEU A 253
 None
 1.45A 3qt0A-4aurA:
undetectable		 3qt0A-4aurA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8d GLYCOSYL HYDROLASE,
FAMILY 35

(Streptococcus
pneumoniae) 		PF01301
(Glyco_hydro_35) 		4 LYS A 436
GLN A 417
ILE A 431
LEU A 479
 None
 1.30A 3qt0A-4e8dA:
undetectable		 3qt0A-4e8dA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h41 PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF14488
(DUF4434)
PF17134
(DUF5109) 		4 LYS A 229
GLN A 269
ILE A  72
LEU A 312
 None
UNL  A 401 ( 3.7A)
None
None
 1.31A 3qt0A-4h41A:
undetectable		 3qt0A-4h41A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		4 LYS A 690
GLN A 534
ILE A 468
LEU A 737
 None
 1.30A 3qt0A-4hsuA:
undetectable		 3qt0A-4hsuA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		4 LYS A 341
GLN A 382
ILE A 370
LEU A 422
 None
 1.20A 3qt0A-4mzdA:
undetectable		 3qt0A-4mzdA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oon PENICILLIN-BINDING
PROTEIN 1A

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		4 LYS A 695
GLN A 673
ILE A 667
LEU A 513
 2U4  A 901 ( 4.3A)
None
None
None
 1.39A 3qt0A-4oonA:
undetectable		 3qt0A-4oonA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		4 LYS A 163
GLN A 157
ILE A 351
LEU A 231
 None
 1.42A 3qt0A-4rnzA:
undetectable		 3qt0A-4rnzA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1

(Chaetomium
thermophilum) 		PF00400
(WD40) 		4 LYS B 696
GLN B 743
ILE B 779
LEU B 777
 None
 1.49A 3qt0A-5cxcB:
undetectable		 3qt0A-5cxcB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f05 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF5

(Populus
trichocarpa) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LYS A  82
GLN A  78
ILE A  71
LEU A  19
 None
 1.44A 3qt0A-5f05A:
undetectable		 3qt0A-5f05A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7z MATERNAL PROTEIN
EXUPERANTIA

(Drosophila
melanogaster) 		no annotation 4 LYS A 106
GLN A  53
ILE A 148
LEU A 116
 None
 1.25A 3qt0A-5l7zA:
undetectable		 3qt0A-5l7zA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7z MATERNAL PROTEIN
EXUPERANTIA

(Drosophila
melanogaster) 		no annotation 4 LYS A 106
GLN A  53
ILE A 148
LEU A 157
 None
 1.20A 3qt0A-5l7zA:
undetectable		 3qt0A-5l7zA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l80 MATERNAL PROTEIN
EXUPERANTIA,MATERNAL
PROTEIN EXUPERANTIA

(Drosophila
melanogaster) 		no annotation 4 LYS A 106
GLN A  53
ILE A 148
LEU A 116
 None
 1.22A 3qt0A-5l80A:
undetectable		 3qt0A-5l80A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l80 MATERNAL PROTEIN
EXUPERANTIA,MATERNAL
PROTEIN EXUPERANTIA

(Drosophila
melanogaster) 		no annotation 4 LYS A 106
GLN A  53
ILE A 148
LEU A 157
 None
 1.28A 3qt0A-5l80A:
undetectable		 3qt0A-5l80A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 LYS A 100
GLN A 128
ILE A 247
LEU A 267
 None
 1.37A 3qt0A-5ltaA:
undetectable		 3qt0A-5ltaA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 4 LYS B 216
GLN B 104
ILE B 179
LEU B 208
 None
 1.35A 3qt0A-5ovnB:
undetectable		 3qt0A-5ovnB:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 LYS A 284
GLN A 277
ILE A 274
LEU A  27
 None
 1.41A 3qt0A-5u03A:
undetectable		 3qt0A-5u03A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxl INVASIN IPAD
SINGLE-DOMAIN
ANTIBODY JPS-G3

(Shigella
flexneri;
Vicugna pacos) 		PF06511
(IpaD)
no annotation 		4 LYS A 291
GLN A 165
ILE B  30
LEU A 174
 None
 1.08A 3qt0A-5vxlA:
undetectable		 3qt0A-5vxlA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 4 LYS A 861
GLN A 937
ILE A 948
LEU A 906
 None
 1.21A 3qt0A-6b3eA:
undetectable		 3qt0A-6b3eA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfp VCA0883

(Vibrio cholerae) 		no annotation 4 LYS A 191
GLN A  13
ILE A  76
LEU A 140
 None
 1.20A 3qt0A-6dfpA:
2.4		 3qt0A-6dfpA:
15.79