SIMILAR PATTERNS OF AMINO ACIDS FOR 3QT0_A_486A4_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1np8 | CALCIUM-DEPENDENTPROTEASE, SMALLSUBUNIT (Rattusnorvegicus) |
PF13833(EF-hand_8) | 5 | CYH A 148ALA A 117LEU A 110ILE A 125MET A 128 | None | 1.21A | 3qt0A-1np8A:undetectable | 3qt0A-1np8A:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pqu | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Haemophilusinfluenzae) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | ARG A 270SER A 166ALA A 168LEU A 176ILE A 271 | CYS A1374 (-2.5A)NAP A1372 (-4.8A)CYS A1374 ( 4.8A)NoneNone | 1.38A | 3qt0A-1pquA:0.0 | 3qt0A-1pquA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tkc | TRANSKETOLASE (Saccharomycescerevisiae) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | ALA A 41TYR A 297LEU A 80ILE A 17HIS A 296 | None | 1.40A | 3qt0A-1tkcA:0.0 | 3qt0A-1tkcA:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vme | FLAVOPROTEIN (Thermotogamaritima) |
PF00258(Flavodoxin_1) | 5 | ALA A 68TYR A 16LEU A 44ILE A 101LYS A 46 | None | 1.40A | 3qt0A-1vmeA:undetectable | 3qt0A-1vmeA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yts | YERSINIA PROTEINTYROSINE PHOSPHATASE (Yersiniaenterocolitica) |
PF00102(Y_phosphatase) | 5 | CYH A 259SER A 403ALA A 286LEU A 282MET A 273 | NoneSO4 A 1 ( 2.8A)NoneNoneNone | 1.49A | 3qt0A-1ytsA:undetectable | 3qt0A-1ytsA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7a | CONSERVEDHYPOTHETICAL PROTEIN (Pseudomonasaeruginosa) |
PF01522(Polysacc_deac_1) | 5 | CYH A 42ARG A 41SER A 50ALA A 52MET A 104 | None | 1.36A | 3qt0A-1z7aA:0.0 | 3qt0A-1z7aA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gwn | DIHYDROOROTASE (Porphyromonasgingivalis) |
PF01979(Amidohydro_1) | 5 | CYH A 217SER A 221ALA A 224ILE A 187HIS A 239 | NoneNoneNoneNone ZN A 601 (-3.5A) | 1.28A | 3qt0A-2gwnA:0.0 | 3qt0A-2gwnA:20.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p54 | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | CYH A 276LEU A 321ILE A 339LYS A 358HIS A 440 | 735 A 469 (-2.9A)735 A 469 ( 4.3A)735 A 469 ( 4.1A)None735 A 469 (-4.0A) | 1.45A | 3qt0A-2p54A:36.6 | 3qt0A-2p54A:61.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rkc | HEMAGGLUTININ (Measlesmorbillivirus) |
PF00423(HN) | 5 | SER A 414ALA A 363TYR A 452LEU A 443PHE A 476 | None | 1.36A | 3qt0A-2rkcA:0.0 | 3qt0A-2rkcA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w4g | MYOSIN HEAVY CHAIN,SKELETAL MUSCLE,ADULT (Gallus gallus) |
PF00063(Myosin_head)PF02736(Myosin_N) | 5 | CYH M 479ARG M 654ALA M 651LEU M 536ILE M 526 | None | 1.32A | 3qt0A-2w4gM:0.0 | 3qt0A-2w4gM:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2waa | XYLAN ESTERASE,PUTATIVE, AXE2C (Cellvibriojaponicus) |
PF13472(Lipase_GDSL_2) | 5 | SER A 231TYR A 167LEU A 329ILE A 336MET A 337 | None | 1.49A | 3qt0A-2waaA:undetectable | 3qt0A-2waaA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wu8 | GLUCOSE-6-PHOSPHATEISOMERASE (Mycobacteriumtuberculosis) |
PF00342(PGI) | 5 | SER A 480TYR A 174LEU A 171ILE A 486PHE A 408 | None | 1.45A | 3qt0A-2wu8A:undetectable | 3qt0A-2wu8A:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xxz | LYSINE-SPECIFICDEMETHYLASE 6B (Homo sapiens) |
PF02373(JmjC) | 5 | CYH A1202LEU A1458ILE A1185PHE A1350MET A1351 | NoneNoneEDO A2496 (-3.5A)NoneNone | 1.50A | 3qt0A-2xxzA:undetectable | 3qt0A-2xxzA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z7x | TOLL-LIKE RECEPTOR2, VARIABLELYMPHOCYTE RECEPTORB (Eptatretusburgeri;Homo sapiens) |
PF11921(DUF3439)PF13855(LRR_8) | 5 | SER A 108TYR A 136LEU A 112ILE A 67PHE A 120 | None | 1.39A | 3qt0A-2z7xA:undetectable | 3qt0A-2z7xA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z80 | TOLL-LIKE RECEPTOR2, VARIABLELYMPHOCYTE RECEPTORB (Eptatretusburgeri;Homo sapiens) |
PF11921(DUF3439)PF13855(LRR_8) | 5 | SER A 108TYR A 136LEU A 112ILE A 67PHE A 120 | None | 1.48A | 3qt0A-2z80A:undetectable | 3qt0A-2z80A:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a2b | SERINEPALMITOYLTRANSFERASE (Sphingobacteriummultivorum) |
PF00155(Aminotran_1_2) | 5 | SER A 227ALA A 226TYR A 101LEU A 215ILE A 183 | None | 1.47A | 3qt0A-3a2bA:undetectable | 3qt0A-3a2bA:22.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b0q | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 10 | ARG A 288ALA A 292TYR A 327LEU A 330ILE A 341MET A 348PHE A 363MET A 364LYS A 367HIS A 449 | NoneNoneNoneMC5 A 1 (-4.4A)MC5 A 1 (-4.5A)MC5 A 1 ( 4.0A)NoneMC5 A 1 (-3.7A)NoneMC5 A 1 (-3.9A) | 0.72A | 3qt0A-3b0qA:38.5 | 3qt0A-3b0qA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b0q | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 10 | CYH A 285ARG A 288ALA A 292TYR A 327LEU A 330ILE A 341MET A 348PHE A 363LYS A 367HIS A 449 | MC5 A 1 (-3.6A)NoneNoneNoneMC5 A 1 (-4.4A)MC5 A 1 (-4.5A)MC5 A 1 ( 4.0A)NoneNoneMC5 A 1 (-3.9A) | 0.61A | 3qt0A-3b0qA:38.5 | 3qt0A-3b0qA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b0q | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 10 | CYH A 285ARG A 288SER A 289ALA A 292LEU A 330ILE A 341MET A 348PHE A 363LYS A 367HIS A 449 | MC5 A 1 (-3.6A)NoneMC5 A 1 (-2.6A)NoneMC5 A 1 (-4.4A)MC5 A 1 (-4.5A)MC5 A 1 ( 4.0A)NoneNoneMC5 A 1 (-3.9A) | 0.77A | 3qt0A-3b0qA:38.5 | 3qt0A-3b0qA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b2d | CD180 ANTIGEN (Homo sapiens) |
PF00560(LRR_1)PF13855(LRR_8) | 5 | SER A 528ALA A 551TYR A 547LEU A 548ILE A 511 | None | 1.36A | 3qt0A-3b2dA:undetectable | 3qt0A-3b2dA:19.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cf0 | TRANSITIONALENDOPLASMICRETICULUM ATPASE (Mus musculus) |
PF00004(AAA)PF09336(Vps4_C) | 5 | ALA A 622LEU A 639ILE A 601PHE A 563MET A 608 | None | 1.47A | 3qt0A-3cf0A:undetectable | 3qt0A-3cf0A:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d7r | ESTERASE (Staphylococcusaureus) |
PF07859(Abhydrolase_3) | 5 | SER A 160LEU A 183ILE A 233MET A 260MET A 241 | None | 1.42A | 3qt0A-3d7rA:undetectable | 3qt0A-3d7rA:20.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 6 | ALA D 292LEU D 330ILE D 341MET D 348MET D 364HIS D 449 | PLB D 701 ( 4.1A)PLB D 701 ( 4.1A)PLB D 701 (-3.6A)PLB D 701 ( 4.7A)PLB D 701 ( 4.8A)None | 1.10A | 3qt0A-3dzuD:36.1 | 3qt0A-3dzuD:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 6 | ALA D 292TYR D 327LEU D 330ILE D 341MET D 364HIS D 449 | PLB D 701 ( 4.1A)NonePLB D 701 ( 4.1A)PLB D 701 (-3.6A)PLB D 701 ( 4.8A)None | 1.16A | 3qt0A-3dzuD:36.1 | 3qt0A-3dzuD:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 6 | CYH D 285ALA D 292TYR D 327LEU D 330ILE D 341HIS D 449 | PLB D 701 (-3.2A)PLB D 701 ( 4.1A)NonePLB D 701 ( 4.1A)PLB D 701 (-3.6A)None | 1.12A | 3qt0A-3dzuD:36.1 | 3qt0A-3dzuD:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 5 | SER D 289ALA D 292ILE D 341MET D 348HIS D 449 | PLB D 701 ( 3.9A)PLB D 701 ( 4.1A)PLB D 701 (-3.6A)PLB D 701 ( 4.7A)None | 0.87A | 3qt0A-3dzuD:36.1 | 3qt0A-3dzuD:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 5 | SER D 289ALA D 292TYR D 327ILE D 341HIS D 449 | PLB D 701 ( 3.9A)PLB D 701 ( 4.1A)NonePLB D 701 (-3.6A)None | 0.97A | 3qt0A-3dzuD:36.1 | 3qt0A-3dzuD:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q0c | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-9 SPECIFICSUVH5 (Arabidopsisthaliana) |
no annotation | 5 | SER X 409ALA X 407TYR X 428LEU X 513ILE X 516 | None | 1.42A | 3qt0A-3q0cX:undetectable | 3qt0A-3q0cX:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qkw | NUCLEOTIDE SUGARSYNTHETASE-LIKEPROTEIN (Streptococcusparasanguinis) |
no annotation | 5 | TYR A 238LEU A 105ILE A 118MET A 143MET A 134 | None | 1.31A | 3qt0A-3qkwA:undetectable | 3qt0A-3qkwA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t6q | CD180 ANTIGEN (Mus musculus) |
PF13855(LRR_8) | 5 | SER A 528ALA A 551TYR A 547LEU A 548ILE A 511 | None | 1.40A | 3qt0A-3t6qA:undetectable | 3qt0A-3t6qA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zzu | ELONGATION FACTOR G (Staphylococcusaureus) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03144(GTP_EFTU_D2)PF03764(EFG_IV)PF14492(EFG_II) | 5 | ARG A 130ALA A 123ILE A 131MET A 270LYS A 23 | None | 1.48A | 3qt0A-3zzuA:undetectable | 3qt0A-3zzuA:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f9o | HEXOKINASE-1 (Homo sapiens) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 5 | CYH A 823SER A 827ALA A 830ILE A 757PHE A 786 | None | 1.04A | 3qt0A-4f9oA:undetectable | 3qt0A-4f9oA:16.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fhn | NUCLEOPORIN NUP120 (Schizosaccharomycespombe) |
PF11715(Nup160) | 5 | ALA B 202TYR B 129LEU B 137ILE B 165MET B 175 | None | 1.35A | 3qt0A-4fhnB:undetectable | 3qt0A-4fhnB:13.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fmu | HISTONE-LYSINEN-METHYLTRANSFERASESETD2 (Homo sapiens) |
PF00856(SET) | 5 | CYH A1580ARG A1625SER A1624LEU A1475HIS A1549 | None0UM A1804 (-4.9A)NoneNoneNone | 1.48A | 3qt0A-4fmuA:undetectable | 3qt0A-4fmuA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fog | THYMIDYLATE SYNTHASE (Mycobacteriumtuberculosis) |
PF00303(Thymidylat_synt) | 5 | LEU A 59ILE A 238MET A 188PHE A 150HIS A 147 | NoneNoneNoneNoneUFP A 301 (-4.0A) | 1.20A | 3qt0A-4fogA:undetectable | 3qt0A-4fogA:24.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nwo | MOLYBDENUM COFACTORBIOSYNTHESIS PROTEINMOGA (Shewanellaoneidensis) |
PF00994(MoCF_biosynth) | 5 | ALA A 62LEU A 123ILE A 154PHE A 99MET A 96 | None | 1.36A | 3qt0A-4nwoA:undetectable | 3qt0A-4nwoA:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ztb | PROTEASE NSP2 (Chikungunyavirus) |
PF01707(Peptidase_C9) | 5 | CYH A 285ARG A 153TYR A 172LEU A 174HIS A 217 | GOL A 401 ( 4.5A)NoneNoneNoneNone | 1.15A | 3qt0A-4ztbA:undetectable | 3qt0A-4ztbA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c1b | TRANSITIONALENDOPLASMICRETICULUM ATPASE (Homo sapiens) |
PF00004(AAA)PF02359(CDC48_N)PF02933(CDC48_2)PF09336(Vps4_C) | 5 | ALA A 622LEU A 639ILE A 601PHE A 563MET A 608 | NoneNone CL A 905 (-4.6A)NoneNone | 1.46A | 3qt0A-5c1bA:undetectable | 3qt0A-5c1bA:16.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cqb | DITRANS,POLYCIS-UNDECAPRENYL-DIPHOSPHATESYNTHASE((2E,6E)-FARNESYL-DIPHOSPHATE SPECIFIC) (Escherichiacoli) |
PF01255(Prenyltransf) | 5 | SER A 55ALA A 58LEU A 139ILE A 23MET A 25 | None | 1.21A | 3qt0A-5cqbA:undetectable | 3qt0A-5cqbA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kd5 | METALLOPEPTIDASE (Bacteroidesthetaiotaomicron) |
PF13402(Peptidase_M60)PF17291(M60-like_N) | 5 | SER A 696ALA A 699LEU A 652ILE A 584PHE A 712 | None | 1.27A | 3qt0A-5kd5A:undetectable | 3qt0A-5kd5A:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u8s | CELL DIVISIONCONTROL PROTEIN 45 (Saccharomycescerevisiae) |
PF02724(CDC45) | 5 | LEU E 348ILE E 404PHE E 363MET E 362HIS E 360 | None | 1.34A | 3qt0A-5u8sE:undetectable | 3qt0A-5u8sE:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b8d | ELONGATION FACTOR G (Haemophilusinfluenzae) |
no annotation | 5 | ARG A 137ALA A 130ILE A 138MET A 278LYS A 23 | None | 1.49A | 3qt0A-6b8dA:undetectable | 3qt0A-6b8dA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bac | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Neisseriagonorrhoeae) |
no annotation | 5 | ARG A 268SER A 165ALA A 167LEU A 175ILE A 269 | SO4 A 403 (-4.1A)NoneSO4 A 403 ( 4.5A)NoneNone | 1.24A | 3qt0A-6bacA:undetectable | 3qt0A-6bacA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bk7 | ELONGATION FACTOR G (Enterococcusfaecalis) |
no annotation | 5 | ARG A 130ALA A 123ILE A 131MET A 270LYS A 23 | None | 1.31A | 3qt0A-6bk7A:undetectable | 3qt0A-6bk7A:15.00 |