SIMILAR PATTERNS OF AMINO ACIDS FOR 3QPK_B_CUB603_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
TRP A 107
HIS A 109
HIS A 454
 CU  A1500 ( 3.2A)
CU  A1500 ( 4.7A)
CU  A1500 (-3.3A)
CU  A1500 (-3.3A)
 0.21A 3qpkB-1gycA:
42.9		 3qpkB-1gycA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
TRP A 107
HIS A 109
HIS A 453
 CU  A 703 (-3.0A)
CU  A 703 (-4.0A)
CU  A 703 (-3.2A)
CU  A 703 (-3.3A)
 0.20A 3qpkB-1hfuA:
41.3		 3qpkB-1hfuA:
31.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
TRP A 107
HIS A 109
HIS A 454
 CU  A 502 (-3.3A)
CU  A 502 ( 4.9A)
CU  A 502 (-3.7A)
CU  A 502 (-3.4A)
 0.24A 3qpkB-1kyaA:
42.9		 3qpkB-1kyaA:
34.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
TRP A 107
HIS A 109
HIS A 453
 CU  A1500 ( 2.9A)
CU  A1500 (-4.2A)
CU  A1500 (-3.3A)
CU  A1500 (-3.4A)
 0.22A 3qpkB-1v10A:
42.4		 3qpkB-1v10A:
32.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  83
TRP A 124
HIS A 126
HIS A 485
 CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1003 (-3.4A)
 0.19A 3qpkB-1zpuA:
40.5		 3qpkB-1zpuA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 103
TRP A 139
HIS A 141
HIS A 501
 C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.4A)
 0.23A 3qpkB-2fqdA:
28.8		 3qpkB-2fqdA:
25.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
TRP A 107
HIS A 109
HIS A 454
 CU  A 603 ( 3.1A)
CU  A 603 ( 4.4A)
CU  A 603 (-3.4A)
CU  A 603 (-3.3A)
 0.29A 3qpkB-2hzhA:
43.0		 3qpkB-2hzhA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
TRP A 107
HIS A 109
HIS A 453
 CU  A 502 ( 3.1A)
CU  A 502 (-4.2A)
CU  A 502 (-3.2A)
CU  A 502 (-3.3A)
 0.24A 3qpkB-2qt6A:
42.8		 3qpkB-2qt6A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
TRP A 107
HIS A 109
HIS A 452
 CU  A 503 (-3.1A)
CU  A 503 ( 4.3A)
CU  A 503 ( 3.2A)
CU  A 503 ( 3.3A)
 0.21A 3qpkB-2xybA:
43.2		 3qpkB-2xybA:
34.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  96
TRP A 132
HIS A 134
HIS A 458
 CU  A 702 ( 3.2A)
CU  A 702 (-4.3A)
CU  A 702 (-3.1A)
CU  A 702 (-3.5A)
 0.41A 3qpkB-3abgA:
26.7		 3qpkB-3abgA:
25.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  95
TRP A 136
HIS A 138
HIS A 504
 CU  A 603 ( 3.2A)
CU  A 603 (-4.2A)
CU  A 603 ( 3.3A)
CU  A 603 ( 3.3A)
 0.22A 3qpkB-3dkhA:
65.9		 3qpkB-3dkhA:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 163
TRP A 199
HIS A 201
HIS A 604
 C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
C2O  A1002 (-3.9A)
 0.31A 3qpkB-3gyrA:
22.5		 3qpkB-3gyrA:
25.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
TRP A 107
HIS A 109
HIS A 457
 CU  A 604 ( 2.9A)
CU  A 604 (-4.1A)
CU  A 604 (-3.2A)
CU  A 604 (-3.1A)
 0.25A 3qpkB-3kw7A:
42.2		 3qpkB-3kw7A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  96
TRP A 137
HIS A 139
HIS A 505
 CU  A 603 ( 3.1A)
CU  A 603 ( 4.5A)
CU  A 603 ( 3.1A)
CU  A 603 ( 3.3A)
 0.11A 3qpkB-3ppsA:
62.4		 3qpkB-3ppsA:
75.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
TRP A 107
HIS A 109
HIS A 454
 CU  A1501 ( 3.0A)
CU  A1501 (-4.1A)
CU  A1501 (-3.2A)
CU  A1501 (-3.3A)
 0.26A 3qpkB-3pxlA:
42.8		 3qpkB-3pxlA:
32.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  67
TRP A 108
HIS A 110
HIS A 454
 CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
OXY  A 511 ( 3.2A)
 0.21A 3qpkB-3t6wA:
42.7		 3qpkB-3t6wA:
31.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  89
TRP A 129
HIS A 131
HIS A 490
 CU  A 603 (-2.9A)
CU  A 603 (-4.0A)
CU  A 603 (-3.2A)
CU  A 603 (-3.5A)
 0.33A 3qpkB-3v9eA:
52.3		 3qpkB-3v9eA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  87
TRP A 128
HIS A 130
HIS A 476
 CU  A 615 ( 3.1A)
CU  A 615 (-4.2A)
CU  A 615 (-3.2A)
CU  A 615 (-3.2A)
 0.21A 3qpkB-3x1bA:
42.7		 3qpkB-3x1bA:
32.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 141
TRP A 178
HIS A 180
HIS A 496
 CU  A 602 (-3.0A)
CU  A 602 ( 4.9A)
CU  A 602 ( 3.1A)
CU  A 602 ( 3.3A)
 0.36A 3qpkB-3zx1A:
28.0		 3qpkB-3zx1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 107
TRP A 151
HIS A 153
HIS A 493
 CU  A 602 (-3.1A)
CU  A 602 ( 4.5A)
CU  A 602 ( 3.2A)
CU  A 602 ( 3.2A)
 0.20A 3qpkB-4akoA:
26.8		 3qpkB-4akoA:
26.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
TRP A 107
HIS A 109
HIS A 451
 CU  A 502 ( 3.1A)
CU  A 502 (-4.2A)
CU  A 502 (-3.2A)
CU  A 502 (-3.3A)
 0.25A 3qpkB-4jhvA:
42.4		 3qpkB-4jhvA:
32.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ku0 UNCHARACTERIZED 10.2
KDA PROTEIN IN
SEGC-GP6 INTERGENIC
REGION

(Escherichia
virus T4) 		PF05488
(PAAR_motif) 		4 HIS D  46
TRP D  17
HIS D  56
HIS D  14
 FE  D 101 (-3.2A)
None
FE  D 101 (-3.2A)
FE  D 101 (-3.2A)
 1.33A 3qpkB-4ku0D:
undetectable		 3qpkB-4ku0D:
10.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
TRP A 107
HIS A 109
HIS A 452
 CU  A 508 ( 3.1A)
CU  A 508 ( 4.8A)
CU  A 508 (-3.3A)
CU  A 508 (-3.2A)
 0.18A 3qpkB-5ehfA:
42.6		 3qpkB-5ehfA:
31.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  97
TRP A 133
HIS A 135
HIS A 446
 CU  A1465 (-3.1A)
CU  A1465 (-4.1A)
CU  A1465 (-3.2A)
CU  A1465 (-3.3A)
 0.20A 3qpkB-5g3fA:
30.6		 3qpkB-5g3fA:
24.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 110
TRP A 150
HIS A 152
HIS A 517
 CU  A 601 (-2.9A)
CU  A 601 ( 4.4A)
CU  A 601 ( 3.2A)
CU  A 601 ( 3.5A)
 0.32A 3qpkB-5lm8A:
49.4		 3qpkB-5lm8A:
37.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  67
TRP A 108
HIS A 110
HIS A 454
 CU  A 502 ( 2.9A)
CU  A 502 (-4.2A)
CU  A 502 (-3.1A)
CU  A 502 ( 3.2A)
 0.20A 3qpkB-5mewA:
42.5		 3qpkB-5mewA:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A  93
TRP A 129
HIS A 131
HIS A 491
 None
 0.43A 3qpkB-6evgA:
28.4		 3qpkB-6evgA:
undetectable