SIMILAR PATTERNS OF AMINO ACIDS FOR 3QPK_B_CUB602_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 106
HIS A 450
HIS A 506
 CU  A 555 (-3.3A)
CU  A 555 ( 3.2A)
CU  A 555 (-3.1A)
 0.18A 3qpkB-1asoA:
38.5		 3qpkB-1asoA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 HIS A 109
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.25A 3qpkB-1bt2A:
undetectable		 3qpkB-1bt2A:
21.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 400
HIS A 452
 CU  A1501 (-3.4A)
CU  A1501 ( 3.2A)
CU  A1501 (-3.3A)
 0.16A 3qpkB-1gycA:
42.9		 3qpkB-1gycA:
30.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 224
HIS A 194
HIS A 198
 CU  A 665 (-3.5A)
CU  A 665 (-3.0A)
CU  A 665 (-3.1A)
 0.59A 3qpkB-1hcyA:
2.4		 3qpkB-1hcyA:
22.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 401
HIS A 451
 CU  A 702 (-3.2A)
CU  A 702 (-3.2A)
CU  A 702 (-3.2A)
 0.15A 3qpkB-1hfuA:
41.3		 3qpkB-1hfuA:
31.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Escherichia
coli) 		PF00293
(NUDIX) 		3 HIS A  25
HIS A  32
HIS A  69
 MN  A1001 (-3.4A)
MN  A1001 (-3.4A)
MN  A1001 (-3.1A)
 0.48A 3qpkB-1i9aA:
undetectable		 3qpkB-1i9aA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A2562
HIS A2571
HIS A2543
 CUO  A 888 (-3.4A)
CUO  A 888 (-3.3A)
CUO  A 888 (-3.4A)
 0.38A 3qpkB-1js8A:
undetectable		 3qpkB-1js8A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA

(Treponema
pallidum) 		PF01297
(ZnuA) 		3 HIS A 133
HIS A  68
HIS A 199
 None
 0.49A 3qpkB-1k0fA:
undetectable		 3qpkB-1k0fA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A1022
HIS A 103
HIS A 161
 CU  A1051 (-3.2A)
CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
 0.28A 3qpkB-1kcwA:
15.7		 3qpkB-1kcwA:
19.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 400
HIS A 452
 CU  A 501 (-3.5A)
CU  A 501 ( 3.3A)
CU  A 501 (-3.4A)
 0.16A 3qpkB-1kyaA:
42.9		 3qpkB-1kyaA:
34.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A  61
HIS A  70
HIS A  41
 CU  A5001 (-3.6A)
CU  A5001 ( 3.1A)
CU  A5001 (-2.9A)
 0.32A 3qpkB-1lnlA:
undetectable		 3qpkB-1lnlA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toa PROTEIN (PERIPLASMIC
BINDING PROTEIN
TROA)

(Treponema
pallidum) 		PF01297
(ZnuA) 		3 HIS A 133
HIS A  68
HIS A 199
 ZN  A 501 ( 3.5A)
ZN  A 501 ( 3.4A)
ZN  A 501 ( 3.4A)
 0.46A 3qpkB-1toaA:
undetectable		 3qpkB-1toaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ton TONIN

(Rattus rattus) 		PF00089
(Trypsin) 		3 HIS A  57
HIS A  97
HIS A  99
 ZN  A 247 (-3.2A)
ZN  A 247 (-3.2A)
ZN  A 247 (-3.2A)
 0.54A 3qpkB-1tonA:
undetectable		 3qpkB-1tonA:
17.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 401
HIS A 451
 CU  A1501 (-3.3A)
CU  A1501 ( 3.2A)
CU  A1501 (-2.9A)
 0.24A 3qpkB-1v10A:
42.3		 3qpkB-1v10A:
32.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		3 HIS A  54
HIS A  63
HIS A  38
 CU  A 400 ( 3.3A)
CU  A 400 ( 3.5A)
CU  A 400 ( 3.3A)
 0.34A 3qpkB-1wx4A:
undetectable		 3qpkB-1wx4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 128
HIS A 418
HIS A 483
 CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.15A 3qpkB-1zpuA:
40.6		 3qpkB-1zpuA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amx ADENOSINE DEAMINASE

(Plasmodium
yoelii) 		PF00962
(A_deaminase) 		3 HIS A 239
HIS A  55
HIS A  57
 CO  A1000 (-3.4A)
CO  A1000 (-3.3A)
CO  A1000 (-3.2A)
 0.55A 3qpkB-2amxA:
undetectable		 3qpkB-2amxA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		3 HIS A 249
HIS A  80
HIS A  82
 ZN  A1601 (-3.4A)
ZN  A1601 (-3.4A)
ZN  A1601 (-3.4A)
 0.55A 3qpkB-2bb0A:
undetectable		 3qpkB-2bb0A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE

(Thermus
thermophilus) 		PF00596
(Aldolase_II) 		3 HIS A  88
HIS A  90
HIS A 151
 None
 0.51A 3qpkB-2fk5A:
undetectable		 3qpkB-2fk5A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 143
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.27A 3qpkB-2fqdA:
28.7		 3qpkB-2fqdA:
25.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 400
HIS A 452
 CU  A 602 (-3.2A)
CU  A 602 ( 3.2A)
CU  A 602 (-3.1A)
 0.14A 3qpkB-2hzhA:
43.0		 3qpkB-2hzhA:
31.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ick ISOPENTENYL-DIPHOSPH
ATE DELTA ISOMERASE

(Homo sapiens) 		PF00293
(NUDIX) 		3 HIS A  41
HIS A  52
HIS A  89
 MN  A 229 (-3.4A)
MN  A 229 (-3.5A)
MN  A 229 ( 3.3A)
 0.60A 3qpkB-2ickA:
undetectable		 3qpkB-2ickA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imr HYPOTHETICAL PROTEIN
DR_0824

(Deinococcus
radiodurans) 		PF01979
(Amidohydro_1) 		3 HIS A  99
HIS A  97
HIS A 238
 ZN  A 500 (-3.2A)
ZN  A 500 (-3.3A)
ZN  A 500 (-3.2A)
 0.55A 3qpkB-2imrA:
undetectable		 3qpkB-2imrA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o03 PROBABLE ZINC UPTAKE
REGULATION PROTEIN
FURB

(Mycobacterium
tuberculosis) 		PF01475
(FUR) 		3 HIS A  80
HIS A  82
HIS A 118
 ZN  A 203 (-3.3A)
ZN  A 203 (-3.1A)
ZN  A 203 (-3.3A)
 0.60A 3qpkB-2o03A:
undetectable		 3qpkB-2o03A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o03 PROBABLE ZINC UPTAKE
REGULATION PROTEIN
FURB

(Mycobacterium
tuberculosis) 		PF01475
(FUR) 		3 HIS A 118
HIS A  82
HIS A  80
 ZN  A 203 (-3.3A)
ZN  A 203 (-3.1A)
ZN  A 203 (-3.3A)
 0.52A 3qpkB-2o03A:
undetectable		 3qpkB-2o03A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		3 HIS A 234
HIS A  79
HIS A  81
 GUN  A 600 ( 2.8A)
ZN  A 500 ( 3.3A)
ZN  A 500 ( 3.3A)
 0.58A 3qpkB-2oodA:
undetectable		 3qpkB-2oodA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 HIS A 108
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.24A 3qpkB-2p3xA:
undetectable		 3qpkB-2p3xA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puz IMIDAZOLONEPROPIONAS
E

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		3 HIS A 256
HIS A  86
HIS A  88
 FE  A 500 (-3.6A)
FE  A 500 (-3.3A)
FE  A 500 (-3.3A)
 0.57A 3qpkB-2puzA:
undetectable		 3qpkB-2puzA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q09 IMIDAZOLONEPROPIONAS
E

(unidentified) 		PF01979
(Amidohydro_1) 		3 HIS A 242
HIS A  72
HIS A  74
 FE  A 500 ( 3.5A)
FE  A 500 (-3.4A)
FE  A 500 (-3.2A)
 0.58A 3qpkB-2q09A:
undetectable		 3qpkB-2q09A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		3 HIS A 217
HIS A  60
HIS A  62
 ZN  A 501 (-3.5A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.56A 3qpkB-2qt3A:
undetectable		 3qpkB-2qt3A:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 399
HIS A 451
 CU  A 501 ( 3.2A)
CU  A 501 ( 3.2A)
CU  A 501 (-3.2A)
 0.14A 3qpkB-2qt6A:
42.8		 3qpkB-2qt6A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 400
HIS A 450
 CU  A 502 (-3.2A)
CU  A 502 (-3.2A)
CU  A 502 ( 3.3A)
 0.15A 3qpkB-2xybA:
43.2		 3qpkB-2xybA:
34.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		3 HIS A  85
HIS A  94
HIS A  61
 CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
 0.31A 3qpkB-2y9xA:
undetectable		 3qpkB-2y9xA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7b MLR6791 PROTEIN

(Mesorhizobium
japonicum) 		PF00596
(Aldolase_II) 		3 HIS A  92
HIS A  94
HIS A 163
 MN  A 235 (-3.4A)
MN  A 235 (-3.8A)
MN  A 235 (-3.6A)
 0.61A 3qpkB-2z7bA:
undetectable		 3qpkB-2z7bA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 136
HIS A 403
HIS A 456
 CU  A 701 (-3.2A)
CU  A 701 ( 3.1A)
CU  A 701 (-3.3A)
 0.25A 3qpkB-3abgA:
26.7		 3qpkB-3abgA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 134
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.26A 3qpkB-3aw5A:
27.7		 3qpkB-3aw5A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx3 LIPOPROTEIN

(Streptococcus
pneumoniae) 		PF01297
(ZnuA) 		3 HIS A 147
HIS A  71
HIS A 211
 ZN  A 314 (-3.2A)
ZN  A 314 (-3.1A)
ZN  A 314 (-3.3A)
 0.38A 3qpkB-3cx3A:
undetectable		 3qpkB-3cx3A:
17.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 140
HIS A 436
HIS A 502
 CU  A 602 ( 3.3A)
CU  A 602 (-3.2A)
CU  A 602 ( 3.2A)
 0.16A 3qpkB-3dkhA:
65.9		 3qpkB-3dkhA:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewd ADENOSINE DEAMINASE

(Plasmodium
vivax) 		PF00962
(A_deaminase) 		3 HIS A 225
HIS A  42
HIS A  44
 ZN  A 371 ( 3.4A)
ZN  A 371 (-3.3A)
MCF  A 372 ( 3.3A)
 0.60A 3qpkB-3ewdA:
undetectable		 3qpkB-3ewdA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN

(Bos taurus) 		PF03055
(RPE65) 		3 HIS A 527
HIS A 180
HIS A 313
 FE2  A 534 (-3.3A)
FE2  A 534 (-3.4A)
FE2  A 534 (-3.4A)
 0.59A 3qpkB-3fsnA:
undetectable		 3qpkB-3fsnA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		3 HIS A 214
HIS A  61
HIS A  63
 FE  A 502 (-3.6A)
FE  A 502 (-3.1A)
FE  A 502 (-3.1A)
 0.54A 3qpkB-3g77A:
undetectable		 3qpkB-3g77A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 203
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.22A 3qpkB-3gyrA:
22.5		 3qpkB-3gyrA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ht1 REMF PROTEIN

(Streptomyces
resistomycificus) 		PF07883
(Cupin_2) 		3 HIS A  55
HIS A  95
HIS A  59
 NI  A 151 (-3.3A)
NI  A 151 (-3.3A)
NI  A 151 (-3.3A)
 0.47A 3qpkB-3ht1A:
undetectable		 3qpkB-3ht1A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibm CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN

(Halorhodospira
halophila) 		PF07883
(Cupin_2) 		3 HIS A  72
HIS A 110
HIS A  76
 ZN  A 200 (-3.3A)
ZN  A 200 (-3.3A)
ZN  A 200 (-3.3A)
 0.43A 3qpkB-3ibmA:
undetectable		 3qpkB-3ibmA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzv UNCHARACTERIZED
PROTEIN RRU_A2000

(Rhodospirillum
rubrum) 		PF07883
(Cupin_2) 		3 HIS A  69
HIS A 107
HIS A  73
 MN  A 200 (-3.3A)
MN  A 200 (-3.6A)
MN  A 200 (-3.6A)
 0.40A 3qpkB-3jzvA:
undetectable		 3qpkB-3jzvA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgz CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Rhodopseudomonas
palustris) 		PF07883
(Cupin_2) 		3 HIS A  78
HIS A 116
HIS A  82
 MN  A   1 (-3.5A)
MN  A   1 (-3.5A)
MN  A   1 (-3.4A)
 0.38A 3qpkB-3kgzA:
undetectable		 3qpkB-3kgzA:
17.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 405
HIS A 455
 CU  A 603 (-3.2A)
CU  A 603 ( 3.0A)
CU  A 603 (-3.1A)
 0.26A 3qpkB-3kw7A:
42.2		 3qpkB-3kw7A:
32.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgg ADENOSINE DEAMINASE
CECR1

(Homo sapiens) 		PF00962
(A_deaminase)
PF08451
(A_deaminase_N) 		3 HIS A 330
HIS A  86
HIS A  88
 ZN  A 512 ( 3.5A)
ZN  A 512 (-3.4A)
CFE  A 513 ( 3.3A)
 0.56A 3qpkB-3lggA:
undetectable		 3qpkB-3lggA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Streptococcus
suis) 		PF01297
(ZnuA) 		3 HIS A 131
HIS A  68
HIS A 197
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.6A)
ZN  A 401 (-3.4A)
 0.49A 3qpkB-3mfqA:
undetectable		 3qpkB-3mfqA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwm PUTATIVE METAL
UPTAKE REGULATION
PROTEIN

(Streptomyces
coelicolor) 		PF01475
(FUR) 		3 HIS A  84
HIS A  86
HIS A 122
 ZN  A 142 (-3.1A)
ZN  A 142 (-3.2A)
ZN  A 142 (-3.2A)
 0.59A 3qpkB-3mwmA:
undetectable		 3qpkB-3mwmA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwm PUTATIVE METAL
UPTAKE REGULATION
PROTEIN

(Streptomyces
coelicolor) 		PF01475
(FUR) 		3 HIS A 122
HIS A  86
HIS A  84
 ZN  A 142 (-3.2A)
ZN  A 142 (-3.2A)
ZN  A 142 (-3.1A)
 0.48A 3qpkB-3mwmA:
undetectable		 3qpkB-3mwmA:
13.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 141
HIS A 437
HIS A 503
 CU  A 602 ( 3.3A)
CU  A 602 (-3.3A)
CU  A 602 ( 3.3A)
 0.11A 3qpkB-3ppsA:
62.4		 3qpkB-3ppsA:
75.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 400
HIS A 452
 CU  A1500 (-3.2A)
CU  A1500 ( 3.2A)
CU  A1500 (-3.1A)
 0.14A 3qpkB-3pxlA:
42.8		 3qpkB-3pxlA:
32.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 112
HIS A 402
HIS A 452
 CU  A 503 (-3.4A)
CU  A 503 ( 3.2A)
CU  A 503 ( 3.3A)
 0.18A 3qpkB-3t6wA:
42.7		 3qpkB-3t6wA:
31.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 133
HIS A 431
HIS A 488
 CU  A 602 (-3.3A)
CU  A 602 (-3.1A)
CU  A 602 (-3.1A)
 0.25A 3qpkB-3v9eA:
52.3		 3qpkB-3v9eA:
37.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		3 HIS A  94
HIS A 103
HIS A  67
 None
 0.48A 3qpkB-3w6qA:
undetectable		 3qpkB-3w6qA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxw ADIPONECTIN RECEPTOR
PROTEIN 2

(Homo sapiens) 		PF03006
(HlyIII) 		3 HIS A 202
HIS A 352
HIS A 348
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
 0.46A 3qpkB-3wxwA:
undetectable		 3qpkB-3wxwA:
18.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 132
HIS A 422
HIS A 474
 CU  A 616 (-3.2A)
CU  A 616 ( 3.2A)
CU  A 616 (-3.2A)
 0.16A 3qpkB-3x1bA:
42.7		 3qpkB-3x1bA:
32.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 182
HIS A 444
HIS A 494
 CU  A 603 ( 2.8A)
CU  A 603 (-3.1A)
CU  A 603 ( 3.1A)
 0.43A 3qpkB-3zx1A:
28.0		 3qpkB-3zx1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 155
HIS A 424
HIS A 491
 CU  A 603 ( 3.2A)
CU  A 603 (-3.2A)
CU  A 603 ( 3.1A)
 0.19A 3qpkB-4akoA:
26.8		 3qpkB-4akoA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A  60
HIS A  69
HIS A  42
 CUO  A9001 (-3.1A)
CUO  A9001 (-3.1A)
CUO  A9001 (-3.4A)
 0.35A 3qpkB-4bedA:
undetectable		 3qpkB-4bedA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A 482
HIS A 491
HIS A 462
 CUO  A9002 (-3.4A)
CUO  A9002 (-3.4A)
CUO  A9002 (-3.2A)
 0.28A 3qpkB-4bedA:
undetectable		 3qpkB-4bedA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A 896
HIS A 905
HIS A 876
 CUO  A9003 (-3.4A)
CUO  A9003 (-3.5A)
CUO  A9003 (-3.3A)
 0.28A 3qpkB-4bedA:
undetectable		 3qpkB-4bedA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A1311
HIS A1320
HIS A1293
 CUO  A9004 (-3.4A)
CUO  A9004 (-3.5A)
CUO  A9004 (-3.2A)
 0.31A 3qpkB-4bedA:
undetectable		 3qpkB-4bedA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS B1725
HIS B1734
HIS B1705
 CUO  B9005 (-3.1A)
CUO  B9005 (-3.4A)
CUO  B9005 (-3.2A)
 0.35A 3qpkB-4bedB:
3.4		 3qpkB-4bedB:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS B2141
HIS B2150
HIS B2122
 CUO  B9006 (-3.1A)
CUO  B9006 (-3.3A)
CUO  B9006 (-3.2A)
 0.33A 3qpkB-4bedB:
3.4		 3qpkB-4bedB:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS B2561
HIS B2570
HIS B2542
 CUO  B9007 (-3.3A)
CUO  B9007 (-3.3A)
CUO  B9007 (-3.3A)
 0.39A 3qpkB-4bedB:
3.4		 3qpkB-4bedB:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxw ADENOSINE DEAMINASE

(Burkholderia
ambifaria) 		PF00962
(A_deaminase) 		3 HIS A 215
HIS A  34
HIS A  36
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
 0.61A 3qpkB-4gxwA:
undetectable		 3qpkB-4gxwA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0f LAMININ-BINDING
SURFACE PROTEIN

(Streptococcus
agalactiae) 		PF01297
(ZnuA) 		3 HIS A 142
HIS A  66
HIS A 206
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.1A)
ZN  A 401 (-3.4A)
 0.49A 3qpkB-4h0fA:
undetectable		 3qpkB-4h0fA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		3 HIS A 110
HIS A 119
HIS A 102
 CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 (-3.2A)
 0.38A 3qpkB-4j3qA:
undetectable		 3qpkB-4j3qA:
19.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 399
HIS A 449
 CU  A 501 (-3.2A)
CU  A 501 ( 3.2A)
CU  A 501 (-3.1A)
 0.14A 3qpkB-4jhvA:
42.5		 3qpkB-4jhvA:
32.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		3 HIS B  82
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.30A 3qpkB-4ouaB:
undetectable		 3qpkB-4ouaB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		3 HIS A  82
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.29A 3qpkB-4ouaA:
undetectable		 3qpkB-4ouaA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		3 HIS A 209
HIS A  56
HIS A  58
 FE2  A 502 ( 3.4A)
FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
 0.48A 3qpkB-4r85A:
undetectable		 3qpkB-4r85A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		3 HIS A 390
HIS A 408
HIS A 406
 NI  A 502 ( 3.4A)
NI  A 502 (-3.2A)
NI  A 502 ( 3.3A)
 0.36A 3qpkB-4rnzA:
undetectable		 3qpkB-4rnzA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		3 HIS A  68
HIS A  66
HIS A 243
 FE  A 481 (-3.9A)
FE  A 481 (-3.9A)
FE  A 481 (-4.1A)
 0.59A 3qpkB-4v1yA:
undetectable		 3qpkB-4v1yA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		3 HIS A 156
HIS A 298
HIS A 265
 ZN  A 402 (-3.4A)
ZN  A 402 (-3.4A)
ZN  A 402 (-3.4A)
 0.58A 3qpkB-4ymkA:
undetectable		 3qpkB-4ymkA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		3 HIS A 298
HIS A 265
HIS A 156
 ZN  A 402 (-3.4A)
ZN  A 402 (-3.4A)
ZN  A 402 (-3.4A)
 0.61A 3qpkB-4ymkA:
undetectable		 3qpkB-4ymkA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0z AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 HIS A 116
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
CU  A 700 (-3.1A)
 0.15A 3qpkB-4z0zA:
undetectable		 3qpkB-4z0zA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		3 HIS A 116
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
 0.14A 3qpkB-4z11A:
undetectable		 3qpkB-4z11A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		3 HIS A 249
HIS A 348
HIS A 272
 ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.4A)
 0.60A 3qpkB-4zr0A:
undetectable		 3qpkB-4zr0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		3 HIS A 272
HIS A 249
HIS A 348
 ZN  A 402 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
 0.60A 3qpkB-4zr0A:
undetectable		 3qpkB-4zr0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		3 HIS A 348
HIS A 272
HIS A 249
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.4A)
ZN  A 402 (-3.2A)
 0.52A 3qpkB-4zr0A:
undetectable		 3qpkB-4zr0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 3 HIS A 160
HIS A 302
HIS A 269
 ZN  A 402 (-3.2A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
 0.58A 3qpkB-4zyoA:
undetectable		 3qpkB-4zyoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq6 METAL-BINDING
PROTEIN ZINT

(Escherichia
coli) 		PF09223
(ZinT) 		3 HIS A   6
HIS A 193
HIS A   1
 ZN  A1194 (-3.2A)
ZN  A1194 (-3.1A)
ZN  A1194 (-3.1A)
 0.47A 3qpkB-5aq6A:
undetectable		 3qpkB-5aq6A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce9 POLYPHENOL OXIDASE

(Juglans regia) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 HIS A 108
HIS A 117
HIS A  87
 CU  A 402 ( 3.2A)
CU  A 402 ( 3.2A)
CU  A 402 ( 3.2A)
 0.18A 3qpkB-5ce9A:
undetectable		 3qpkB-5ce9A:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 111
HIS A 400
HIS A 450
 CU  A 507 ( 3.3A)
CU  A 507 ( 3.1A)
CU  A 507 (-3.2A)
 0.25A 3qpkB-5ehfA:
42.6		 3qpkB-5ehfA:
31.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 137
HIS A 398
HIS A 444
 CU  A1463 (-3.3A)
CU  A1463 (-2.9A)
CU  A1463 (-3.0A)
 0.55A 3qpkB-5g3fA:
30.6		 3qpkB-5g3fA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		3 HIS A  60
HIS A  69
HIS A  42
 ZN  A 301 ( 3.2A)
ZN  A 302 ( 4.9A)
ZN  A 301 ( 3.2A)
 0.37A 3qpkB-5i3aA:
undetectable		 3qpkB-5i3aA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans) 		PF03055
(RPE65) 		3 HIS A 476
HIS A 218
HIS A 284
 FE  A 501 ( 3.1A)
FE  A 501 (-3.2A)
FE  A 501 ( 3.3A)
 0.58A 3qpkB-5j55A:
undetectable		 3qpkB-5j55A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kja APOCAROTENOID-15,15'
-OXYGENASE

(Synechocystis
sp. PCC 6803) 		PF03055
(RPE65) 		3 HIS A 484
HIS A 183
HIS A 304
 FE2  A 502 (-4.0A)
FE2  A 502 (-4.0A)
FE2  A 502 (-3.8A)
 0.54A 3qpkB-5kjaA:
undetectable		 3qpkB-5kjaA:
23.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 154
HIS A 453
HIS A 515
 CU  A 602 ( 3.4A)
CU  A 602 (-3.1A)
CU  A 602 ( 3.2A)
 0.15A 3qpkB-5lm8A:
49.4		 3qpkB-5lm8A:
37.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		3 HIS A 215
HIS A 224
HIS A 192
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
 0.33A 3qpkB-5m8tA:
undetectable		 3qpkB-5m8tA:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 112
HIS A 402
HIS A 452
 CU  A 501 (-3.1A)
CU  A 501 (-3.2A)
CU  A 501 ( 3.0A)
 0.23A 3qpkB-5mewA:
42.5		 3qpkB-5mewA:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 3 HIS A 162
HIS A 974
HIS A1014
 CU  A1101 (-3.3A)
CU  A1101 ( 3.2A)
CU  A1101 (-3.2A)
 0.45A 3qpkB-5n4lA:
21.2		 3qpkB-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 3 HIS A1016
HIS A 103
HIS A 160
 CU  A1104 (-3.1A)
CU  A1104 ( 3.5A)
CU  A1104 (-3.6A)
 0.36A 3qpkB-5n4lA:
21.2		 3qpkB-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 3 HIS A 110
HIS A 119
HIS A 102
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
 0.35A 3qpkB-5or4A:
undetectable		 3qpkB-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8z CAROTENOID OXYGENASE
1

(Neurospora
crassa) 		PF03055
(RPE65) 		3 HIS A 510
HIS A 197
HIS A 313
 FE2  A 601 (-3.3A)
FE2  A 601 (-3.3A)
FE2  A 601 ( 3.4A)
 0.54A 3qpkB-5u8zA:
undetectable		 3qpkB-5u8zA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		3 HIS A 278
HIS A 264
HIS A 208
 EDO  A 507 (-2.9A)
ZN  A 502 (-3.2A)
ZN  A 502 ( 3.1A)
 0.56A 3qpkB-5uamA:
undetectable		 3qpkB-5uamA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN

(Paracoccus
denitrificans) 		PF01297
(ZnuA) 		3 HIS A 138
HIS A  61
HIS A 204
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
 0.56A 3qpkB-5w57A:
undetectable		 3qpkB-5w57A:
20.34