SIMILAR PATTERNS OF AMINO ACIDS FOR 3QPK_B_CUB601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 445
CYH A 507
ILE A 509
HIS A 512
 CU  A 554 (-3.2A)
CU  A 554 (-2.1A)
CU  A 554 ( 4.1A)
CU  A 554 (-3.1A)
 0.31A 3qpkB-1asoA:
38.5		 3qpkB-1asoA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do6 SUPEROXIDE REDUCTASE

(Pyrococcus
furiosus) 		PF01880
(Desulfoferrodox) 		4 HIS A  47
CYH A 111
ILE A 113
HIS A 114
 FE  A 200 (-3.4A)
FE  A 200 (-2.4A)
None
FE  A 200 (-3.2A)
 1.38A 3qpkB-1do6A:
undetectable		 3qpkB-1do6A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2i FUSION OF N-TERMINAL
17-MER PEPTIDE
EXTENSION TO ZIF12

(Mus musculus) 		PF00096
(zf-C2H2) 		4 HIS G1153
CYH G1137
ILE G1139
HIS G1157
 ZN  G1202 (-3.3A)
ZN  G1202 (-2.4A)
ZN  G1202 ( 4.6A)
ZN  G1202 (-3.3A)
 1.41A 3qpkB-1f2iG:
undetectable		 3qpkB-1f2iG:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhq PROTEIN KINASE SPK1

(Saccharomyces
cerevisiae) 		PF00498
(FHA) 		4 HIS A 651
CYH A 623
ILE A 680
HIS A 622
 None
 1.28A 3qpkB-1fhqA:
undetectable		 3qpkB-1fhqA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g2d TATA BOX ZINC FINGER
PROTEIN

(Mus musculus) 		PF00096
(zf-C2H2)
PF13894
(zf-C2H2_4) 		4 HIS C 181
CYH C 165
ILE C 167
HIS C 185
 ZN  C 303 (-3.3A)
ZN  C 303 (-2.4A)
ZN  C 303 ( 4.9A)
ZN  C 303 (-3.2A)
 1.46A 3qpkB-1g2dC:
undetectable		 3qpkB-1g2dC:
7.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 395
CYH A 453
ILE A 455
HIS A 458
 CU  A1503 (-3.1A)
CU  A1503 (-2.1A)
CU  A1503 ( 3.8A)
CU  A1503 (-3.1A)
 0.31A 3qpkB-1gycA:
42.9		 3qpkB-1gycA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 396
CYH A 452
ILE A 454
HIS A 457
 CU  A 701 (-3.2A)
CU  A 701 (-2.1A)
CU  A 701 ( 3.8A)
CU  A 701 (-3.1A)
 0.27A 3qpkB-1hfuA:
41.3		 3qpkB-1hfuA:
31.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 395
CYH A 453
ILE A 455
HIS A 458
 CU  A 500 (-3.4A)
CU  A 500 (-2.2A)
CU  A 500 (-3.7A)
CU  A 500 ( 3.3A)
 0.38A 3qpkB-1kyaA:
42.9		 3qpkB-1kyaA:
34.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llm CHIMERA OF
ZIF23-GCN4

(Saccharomyces
cerevisiae;
Mus musculus) 		PF00096
(zf-C2H2) 		4 HIS C 150
CYH C 134
ILE C 136
HIS C 155
 ZN  C 302 (-3.3A)
ZN  C 302 (-2.3A)
None
ZN  C 302 (-3.3A)
 1.48A 3qpkB-1llmC:
undetectable		 3qpkB-1llmC:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcy RUSTICYANIN

(Acidithiobacillus
ferrooxidans) 		PF00127
(Copper-bind) 		4 HIS A  85
CYH A 138
ILE A 140
HIS A 143
 CU  A 156 ( 3.1A)
CU  A 156 ( 2.2A)
CU  A 156 ( 4.1A)
CU  A 156 ( 3.0A)
 0.69A 3qpkB-1rcyA:
9.4		 3qpkB-1rcyA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srk ZINC FINGER PROTEIN
ZFPM1

(Mus musculus) 		no annotation 4 HIS A  26
CYH A  10
ILE A  12
HIS A  30
 ZN  A  36 (-3.2A)
ZN  A  36 (-2.2A)
None
ZN  A  36 (-3.2A)
 1.39A 3qpkB-1srkA:
undetectable		 3qpkB-1srkA:
5.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 396
CYH A 452
ILE A 454
HIS A 457
 CU  A1503 (-3.2A)
CU  A1503 (-2.1A)
CU  A1503 (-3.4A)
CU  A1503 (-3.2A)
 0.31A 3qpkB-1v10A:
42.3		 3qpkB-1v10A:
32.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1va1 TRANSCRIPTION FACTOR
SP1

(Homo sapiens) 		no annotation 4 HIS A 557
CYH A 539
ILE A 541
HIS A 561
 ZN  A 100 (-3.1A)
ZN  A 100 (-2.3A)
None
ZN  A 100 (-3.2A)
 1.47A 3qpkB-1va1A:
undetectable		 3qpkB-1va1A:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A  49
CYH A 116
ILE A 118
HIS A 119
 FE  A1129 ( 3.4A)
FE  A1129 (-2.7A)
None
FE  A1129 ( 3.2A)
 1.35A 3qpkB-1vzhA:
undetectable		 3qpkB-1vzhA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A  69
CYH A 116
ILE A 118
HIS A 119
 FE  A1129 ( 3.4A)
FE  A1129 (-2.7A)
None
FE  A1129 ( 3.2A)
 1.27A 3qpkB-1vzhA:
undetectable		 3qpkB-1vzhA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ws7 MAVICYANIN

(Cucurbita pepo) 		PF02298
(Cu_bind_like) 		4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.60A 3qpkB-1ws7A:
4.8		 3qpkB-1ws7A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xj5 SPERMIDINE SYNTHASE
1

(Arabidopsis
thaliana) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.35A 3qpkB-1xj5A:
undetectable		 3qpkB-1xj5A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zaa PROTEIN (ZIF268)

(Mus musculus) 		PF00096
(zf-C2H2) 		4 HIS C  53
CYH C  37
ILE C  39
HIS C  57
 ZN  C 202 (-3.2A)
ZN  C 202 (-2.3A)
ZN  C 202 ( 4.8A)
ZN  C 202 (-3.2A)
 1.38A 3qpkB-1zaaC:
undetectable		 3qpkB-1zaaC:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.29A 3qpkB-1zpuA:
40.6		 3qpkB-1zpuA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct1 TRANSCRIPTIONAL
REPRESSOR CTCF

(Homo sapiens) 		PF00096
(zf-C2H2) 		4 HIS A  34
CYH A  18
ILE A  20
HIS A  39
 ZN  A 201 (-3.4A)
ZN  A 201 (-2.3A)
ZN  A 201 ( 4.2A)
ZN  A 201 (-3.4A)
 1.44A 3qpkB-2ct1A:
undetectable		 3qpkB-2ct1A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct5 ZINC FINGER BED
DOMAIN CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02892
(zf-BED) 		4 HIS A  51
CYH A  32
ILE A  34
HIS A  56
 ZN  A 201 (-3.5A)
ZN  A 201 (-2.3A)
ZN  A 201 ( 4.3A)
ZN  A 201 (-3.4A)
 1.48A 3qpkB-2ct5A:
undetectable		 3qpkB-2ct5A:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dv6 NITRITE REDUCTASE

(Hyphomicrobium
denitrificans) 		PF07732
(Cu-oxidase_3) 		4 HIS A  77
CYH A 114
ILE A 116
HIS A 119
 CU  A 502 (-3.2A)
CU  A 502 (-2.2A)
CU  A 502 ( 4.6A)
CU  A 502 (-3.1A)
 0.68A 3qpkB-2dv6A:
6.6		 3qpkB-2dv6A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eoq ZINC FINGER PROTEIN
224

(Homo sapiens) 		no annotation 4 HIS A  31
CYH A  15
ILE A  17
HIS A  35
 ZN  A 201 ( 3.2A)
ZN  A 201 ( 2.3A)
ZN  A 201 ( 4.2A)
ZN  A 201 ( 3.1A)
 1.41A 3qpkB-2eoqA:
undetectable		 3qpkB-2eoqA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eos B-CELL LYMPHOMA 6
PROTEIN

(Homo sapiens) 		PF00096
(zf-C2H2) 		4 HIS A  30
CYH A  14
ILE A  16
HIS A  34
 ZN  A 201 ( 3.2A)
ZN  A 201 ( 2.3A)
ZN  A 201 ( 4.1A)
ZN  A 201 ( 3.1A)
 1.29A 3qpkB-2eosA:
undetectable		 3qpkB-2eosA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epr POZ-, AT HOOK-, AND
ZINC
FINGER-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 4 HIS A 373
CYH A 357
ILE A 359
HIS A 377
 ZN  A 201 ( 3.2A)
ZN  A 201 (-2.3A)
ZN  A 201 (-4.3A)
ZN  A 201 ( 3.1A)
 1.43A 3qpkB-2eprA:
undetectable		 3qpkB-2eprA:
5.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 395
CYH A 453
ILE A 455
HIS A 458
 CU  A 601 (-3.6A)
CU  A 601 (-2.1A)
CU  A 601 (-3.7A)
CU  A 601 (-3.4A)
 0.45A 3qpkB-2hzhA:
43.0		 3qpkB-2hzhA:
31.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9a E3 UBIQUITIN-PROTEIN
LIGASE ZFP91

(Homo sapiens) 		PF00096
(zf-C2H2) 		4 HIS A  90
CYH A  74
ILE A  76
HIS A  95
 ZN  A 103 (-3.2A)
ZN  A 103 (-2.3A)
ZN  A 103 ( 4.8A)
ZN  A 103 (-3.3A)
 1.47A 3qpkB-2m9aA:
undetectable		 3qpkB-2m9aA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mq1 E3 UBIQUITIN-PROTEIN
LIGASE HAKAI

(Mus musculus) 		no annotation 4 HIS A  80
CYH A  61
ILE A  63
HIS A  85
 ZN  A 103 (-3.1A)
ZN  A 103 (-2.3A)
ZN  A 103 ( 4.9A)
ZN  A 103 (-2.9A)
 1.38A 3qpkB-2mq1A:
undetectable		 3qpkB-2mq1A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mxp CALCIUM-BINDING AND
COILED-COIL
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		no annotation 4 HIS A  75
CYH A  57
ILE A  59
HIS A  79
 ZN  A 101 (-3.2A)
ZN  A 101 (-2.3A)
ZN  A 101 ( 4.3A)
ZN  A 101 (-3.1A)
 1.39A 3qpkB-2mxpA:
undetectable		 3qpkB-2mxpA:
4.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 394
CYH A 452
ILE A 454
HIS A 457
 CU  A 499 (-3.1A)
CU  A 499 (-2.2A)
CU  A 499 (-3.7A)
CU  A 499 (-3.1A)
 0.31A 3qpkB-2qt6A:
42.8		 3qpkB-2qt6A:
31.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7e COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2404 (-3.2A)
CU  B2404 (-2.2A)
CU  B2404 (-2.6A)
CU  B2404 (-3.5A)
 0.99A 3qpkB-2r7eB:
12.4		 3qpkB-2r7eB:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 395
CYH A 451
ILE A 453
HIS A 456
 CU  A 501 (-3.1A)
CU  A 501 (-2.2A)
CU  A 501 (-3.7A)
CU  A 501 ( 3.1A)
 0.31A 3qpkB-2xybA:
43.2		 3qpkB-2xybA:
34.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yt9 ZINC
FINGER-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00096
(zf-C2H2)
PF13894
(zf-C2H2_4) 		4 HIS A 380
CYH A 364
ILE A 366
HIS A 384
 ZN  A 201 (-3.2A)
ZN  A 201 (-2.3A)
ZN  A 201 ( 4.0A)
ZN  A 201 (-3.1A)
 1.42A 3qpkB-2yt9A:
undetectable		 3qpkB-2yt9A:
9.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 431
CYH A 503
ILE A 505
HIS A 508
 CU  A 601 (-3.0A)
CU  A 601 (-2.1A)
CU  A 601 ( 4.0A)
CU  A 601 (-3.3A)
 0.16A 3qpkB-3dkhA:
65.9		 3qpkB-3dkhA:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuf ZINC FINGER PROTEIN
UBI-D4

(Homo sapiens) 		no annotation 4 HIS A 227
CYH A 211
ILE A 213
HIS A 232
 ZN  A   1 (-3.2A)
ZN  A   1 (-2.3A)
ZN  A   1 ( 4.9A)
ZN  A   1 (-3.3A)
 1.44A 3qpkB-3iufA:
undetectable		 3qpkB-3iufA:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 None
 0.39A 3qpkB-3j2sB:
15.3		 3qpkB-3j2sB:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 400
CYH A 456
ILE A 458
HIS A 461
 CU  A 601 (-3.2A)
CU  A 601 (-2.1A)
CU  A 601 (-3.7A)
CU  A 601 (-3.1A)
 0.37A 3qpkB-3kw7A:
42.2		 3qpkB-3kw7A:
32.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF02815
(MIR) 		4 HIS A 177
CYH A 192
ILE A 194
HIS A 175
 None
 1.26A 3qpkB-3malA:
undetectable		 3qpkB-3malA:
16.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 432
CYH A 504
ILE A 506
HIS A 509
 CU  A 601 (-3.1A)
CU  A 601 (-2.1A)
CU  A 601 ( 4.1A)
CU  A 601 (-3.1A)
 0.21A 3qpkB-3ppsA:
62.4		 3qpkB-3ppsA:
75.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 395
CYH A 453
ILE A 455
HIS A 458
 CU  A1503 (-3.1A)
CU  A1503 (-2.1A)
CU  A1503 (-3.7A)
CU  A1503 (-3.1A)
 0.30A 3qpkB-3pxlA:
42.8		 3qpkB-3pxlA:
32.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qzb PUTATIVE SUPEROXIDE
REDUCTASE

(Thermotoga
maritima) 		PF01880
(Desulfoferrodox) 		4 HIS A  51
CYH A 115
ILE A 117
HIS A 118
 FE  A 132 (-3.4A)
FE  A 132 (-2.3A)
None
FE  A 132 (-3.3A)
 1.33A 3qpkB-3qzbA:
2.4		 3qpkB-3qzbA:
14.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 397
CYH A 453
ILE A 455
HIS A 458
 CU  A 501 (-3.1A)
CU  A 501 (-2.0A)
CU  A 501 (-3.8A)
CU  A 501 (-3.3A)
 0.30A 3qpkB-3t6wA:
42.7		 3qpkB-3t6wA:
31.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 426
CYH A 489
ILE A 491
HIS A 494
 CU  A 601 (-3.1A)
CU  A 601 (-2.2A)
CU  A 601 (-4.0A)
CU  A 601 (-3.1A)
 0.30A 3qpkB-3v9eA:
52.3		 3qpkB-3v9eA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 417
CYH A 475
ILE A 477
HIS A 480
 CU  A 617 (-3.1A)
CU  A 617 (-2.2A)
CU  A 617 ( 3.8A)
CU  A 617 (-3.1A)
 0.29A 3qpkB-3x1bA:
42.7		 3qpkB-3x1bA:
32.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 439
CYH A 495
ILE A 497
HIS A 500
 CU  A 601 (-3.1A)
CU  A 601 (-2.2A)
CU  A 601 ( 3.9A)
CU  A 601 (-3.1A)
 0.31A 3qpkB-3zx1A:
28.0		 3qpkB-3zx1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 419
CYH A 492
ILE A 494
HIS A 497
 CU  A 601 (-3.1A)
CU  A 601 (-2.2A)
CU  A 601 ( 4.0A)
CU  A 601 (-3.1A)
 0.27A 3qpkB-4akoA:
26.8		 3qpkB-4akoA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1

(Mus musculus) 		PF08447
(PAS_3) 		4 HIS A 364
CYH A 368
ILE A 493
HIS A 409
 None
 1.42A 3qpkB-4dj2A:
undetectable		 3qpkB-4dj2A:
20.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 394
CYH A 450
ILE A 452
HIS A 455
 CU  A 503 (-3.1A)
CU  A 503 (-2.2A)
CU  A 503 (-3.7A)
CU  A 503 (-3.1A)
 0.28A 3qpkB-4jhvA:
42.5		 3qpkB-4jhvA:
32.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.49A 3qpkB-5a31A:
undetectable		 3qpkB-5a31A:
16.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 395
CYH A 451
ILE A 453
HIS A 456
 CU  A 510 (-3.1A)
CU  A 510 (-2.0A)
CU  A 510 (-3.7A)
CU  A 510 (-3.1A)
 0.37A 3qpkB-5ehfA:
42.6		 3qpkB-5ehfA:
31.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 393
CYH A 445
ILE A 447
HIS A 450
 CU  A1464 (-3.1A)
CU  A1464 (-2.1A)
CU  A1464 ( 3.9A)
CU  A1464 (-3.2A)
 0.37A 3qpkB-5g3fA:
30.6		 3qpkB-5g3fA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.59A 3qpkB-5k8dA:
5.8		 3qpkB-5k8dA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.53A 3qpkB-5k8dB:
16.5		 3qpkB-5k8dB:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 448
CYH A 516
ILE A 518
HIS A 521
 CU  A 604 (-3.1A)
CU  A 604 (-2.1A)
CU  A 604 (-3.8A)
CU  A 604 (-3.0A)
 0.23A 3qpkB-5lm8A:
49.4		 3qpkB-5lm8A:
37.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 397
CYH A 453
ILE A 455
HIS A 458
 CU  A 504 (-3.1A)
CU  A 504 (-2.1A)
CU  A 504 (-3.8A)
CU  A 504 (-3.1A)
 0.30A 3qpkB-5mewA:
42.5		 3qpkB-5mewA:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t00 TRANSCRIPTIONAL
REPRESSOR CTCF

(Homo sapiens) 		PF00096
(zf-C2H2)
PF13909
(zf-H2C2_5) 		4 HIS A 425
CYH A 409
ILE A 411
HIS A 430
 ZN  A 504 (-3.2A)
ZN  A 504 (-2.2A)
ZN  A 504 ( 4.8A)
ZN  A 504 (-3.1A)
 1.41A 3qpkB-5t00A:
undetectable		 3qpkB-5t00A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0u TRANSCRIPTIONAL
REPRESSOR CTCF

(Homo sapiens) 		PF00096
(zf-C2H2)
PF13909
(zf-H2C2_5) 		4 HIS A 425
CYH A 409
ILE A 411
HIS A 430
 ZN  A 505 (-3.2A)
ZN  A 505 (-2.4A)
ZN  A 505 ( 4.5A)
ZN  A 505 (-3.1A)
 1.44A 3qpkB-5t0uA:
undetectable		 3qpkB-5t0uA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeg TRANSCRIPTIONAL
REPRESSOR CTCF

(Homo sapiens) 		no annotation 4 HIS B 425
CYH B 409
ILE B 411
HIS B 430
 ZN  B 502 (-3.3A)
ZN  B 502 (-2.3A)
ZN  B 502 ( 4.8A)
ZN  B 502 (-3.3A)
 1.48A 3qpkB-5yegB:
undetectable		 3qpkB-5yegB:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7paz PSEUDOAZURIN

(Alcaligenes
faecalis) 		PF00127
(Copper-bind) 		4 HIS A  40
CYH A  78
ILE A  80
HIS A  81
 CU  A 124 ( 3.1A)
CU  A 124 ( 2.1A)
CU  A 124 ( 4.3A)
CU  A 124 ( 3.2A)
 0.62A 3qpkB-7pazA:
5.9		 3qpkB-7pazA:
11.45