SIMILAR PATTERNS OF AMINO ACIDS FOR 3QPK_A_CUA604

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  60
HIS A  62
HIS A 448
HIS A 450
 CU  A 557 ( 3.1A)
CU  A 556 ( 3.0A)
CU  A 557 ( 3.2A)
CU  A 555 ( 3.2A)
 0.16A 3qpkA-1asoA:
38.6		 3qpkA-1asoA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 106
HIS A  60
HIS A 450
HIS A 506
 CU  A 555 (-3.3A)
CU  A 557 ( 3.1A)
CU  A 555 ( 3.2A)
CU  A 555 (-3.1A)
 1.33A 3qpkA-1asoA:
38.6		 3qpkA-1asoA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 448
HIS A 450
HIS A  60
HIS A  62
 CU  A 557 ( 3.2A)
CU  A 555 ( 3.2A)
CU  A 557 ( 3.1A)
CU  A 556 ( 3.0A)
 0.87A 3qpkA-1asoA:
38.6		 3qpkA-1asoA:
28.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 398
HIS A 400
 CU  A1502 (-3.1A)
CU  A1500 ( 3.2A)
CU  A1502 ( 3.1A)
CU  A1501 ( 3.2A)
 0.27A 3qpkA-1gycA:
42.8		 3qpkA-1gycA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A  64
HIS A  66
 CU  A1502 ( 3.1A)
CU  A1501 ( 3.2A)
CU  A1502 (-3.1A)
CU  A1500 ( 3.2A)
 0.86A 3qpkA-1gycA:
42.8		 3qpkA-1gycA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 399
HIS A 401
 CU  A 703 (-4.7A)
CU  A 703 (-3.0A)
CU  A 702 ( 3.7A)
CU  A 702 (-3.2A)
 0.80A 3qpkA-1hfuA:
41.3		 3qpkA-1hfuA:
31.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 109
HIS A  64
HIS A 399
HIS A 453
 CU  A 703 (-3.2A)
CU  A 703 (-4.7A)
CU  A 702 ( 3.7A)
CU  A 703 (-3.3A)
 1.05A 3qpkA-1hfuA:
41.3		 3qpkA-1hfuA:
31.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 399
HIS A 453
HIS A 109
HIS A  64
 CU  A 702 ( 3.7A)
CU  A 703 (-3.3A)
CU  A 703 (-3.2A)
CU  A 703 (-4.7A)
 1.19A 3qpkA-1hfuA:
41.3		 3qpkA-1hfuA:
31.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 101
HIS A 103
HIS A 978
HIS A 980
 CU  A1052 (-3.2A)
CU  A1051 (-3.3A)
CU  A1052 ( 3.2A)
CU  A1050 (-3.0A)
 0.78A 3qpkA-1kcwA:
17.2		 3qpkA-1kcwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 161
HIS A 163
HIS A 980
HIS A 103
 CU  A1051 (-3.3A)
CU  A1050 (-3.3A)
CU  A1050 (-3.0A)
CU  A1051 (-3.3A)
 1.29A 3qpkA-1kcwA:
17.2		 3qpkA-1kcwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 978
HIS A 980
HIS A 101
HIS A 103
 CU  A1052 ( 3.2A)
CU  A1050 (-3.0A)
CU  A1052 (-3.2A)
CU  A1051 (-3.3A)
 0.97A 3qpkA-1kcwA:
17.2		 3qpkA-1kcwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 980
HIS A 103
HIS A 161
HIS A 163
 CU  A1050 (-3.0A)
CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
CU  A1050 (-3.3A)
 1.32A 3qpkA-1kcwA:
17.2		 3qpkA-1kcwA:
19.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 398
HIS A 400
 CU  A 503 (-3.2A)
CU  A 502 (-3.3A)
CU  A 503 ( 3.2A)
CU  A 501 ( 3.3A)
 0.33A 3qpkA-1kyaA:
42.9		 3qpkA-1kyaA:
34.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A  64
HIS A  66
 CU  A 503 ( 3.2A)
CU  A 501 ( 3.3A)
CU  A 503 (-3.2A)
CU  A 502 (-3.3A)
 0.87A 3qpkA-1kyaA:
42.9		 3qpkA-1kyaA:
34.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 399
HIS A 401
 CU  A1502 (-3.2A)
CU  A1500 ( 2.9A)
CU  A1502 (-2.9A)
CU  A1501 ( 3.2A)
 0.28A 3qpkA-1v10A:
42.3		 3qpkA-1v10A:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A  64
HIS A 401
HIS A 451
 CU  A1501 (-3.3A)
CU  A1502 (-3.2A)
CU  A1501 ( 3.2A)
CU  A1501 (-2.9A)
 1.32A 3qpkA-1v10A:
42.3		 3qpkA-1v10A:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 399
HIS A 401
HIS A  64
HIS A  66
 CU  A1502 (-2.9A)
CU  A1501 ( 3.2A)
CU  A1502 (-3.2A)
CU  A1500 ( 2.9A)
 0.86A 3qpkA-1v10A:
42.3		 3qpkA-1v10A:
32.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.27A 3qpkA-1zpuA:
40.6		 3qpkA-1zpuA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.83A 3qpkA-1zpuA:
40.6		 3qpkA-1zpuA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.25A 3qpkA-2fqdA:
28.5		 3qpkA-2fqdA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.83A 3qpkA-2fqdA:
28.5		 3qpkA-2fqdA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.29A 3qpkA-2fqdA:
28.5		 3qpkA-2fqdA:
25.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 398
HIS A 400
 CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 604 (-3.1A)
CU  A 602 ( 3.2A)
 0.33A 3qpkA-2hzhA:
42.9		 3qpkA-2hzhA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A  64
HIS A 400
HIS A 452
 CU  A 602 (-3.2A)
CU  A 604 ( 3.1A)
CU  A 602 ( 3.2A)
CU  A 602 (-3.1A)
 1.36A 3qpkA-2hzhA:
42.9		 3qpkA-2hzhA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A  64
HIS A  66
 CU  A 604 (-3.1A)
CU  A 602 ( 3.2A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
 0.92A 3qpkA-2hzhA:
42.9		 3qpkA-2hzhA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 452
HIS A 398
HIS A 400
HIS A 111
 CU  A 602 (-3.1A)
CU  A 604 (-3.1A)
CU  A 602 ( 3.2A)
CU  A 602 (-3.2A)
 1.32A 3qpkA-2hzhA:
42.9		 3qpkA-2hzhA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 397
HIS A 399
 CU  A 500 (-3.1A)
CU  A 502 ( 3.1A)
CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
 0.33A 3qpkA-2qt6A:
42.8		 3qpkA-2qt6A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A  64
HIS A 399
HIS A 451
 CU  A 501 ( 3.2A)
CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
CU  A 501 (-3.2A)
 1.34A 3qpkA-2qt6A:
42.8		 3qpkA-2qt6A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 397
HIS A 399
HIS A  64
HIS A  66
 CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
CU  A 500 (-3.1A)
CU  A 502 ( 3.1A)
 0.90A 3qpkA-2qt6A:
42.8		 3qpkA-2qt6A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 451
HIS A 397
HIS A 399
HIS A 111
 CU  A 501 (-3.2A)
CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
CU  A 501 ( 3.2A)
 1.32A 3qpkA-2qt6A:
42.8		 3qpkA-2qt6A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 398
HIS A 400
 CU  A 504 ( 3.1A)
CU  A 503 (-3.1A)
CU  A 504 (-3.1A)
CU  A 502 (-3.2A)
 0.33A 3qpkA-2xybA:
43.1		 3qpkA-2xybA:
34.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A  64
HIS A 400
HIS A 450
 CU  A 502 (-3.2A)
CU  A 504 ( 3.1A)
CU  A 502 (-3.2A)
CU  A 502 ( 3.3A)
 1.36A 3qpkA-2xybA:
43.1		 3qpkA-2xybA:
34.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A  64
HIS A  66
 CU  A 504 (-3.1A)
CU  A 502 (-3.2A)
CU  A 504 ( 3.1A)
CU  A 503 (-3.1A)
 0.93A 3qpkA-2xybA:
43.1		 3qpkA-2xybA:
34.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 450
HIS A 398
HIS A 400
HIS A 111
 CU  A 502 ( 3.3A)
CU  A 504 (-3.1A)
CU  A 502 (-3.2A)
CU  A 502 (-3.2A)
 1.31A 3qpkA-2xybA:
43.1		 3qpkA-2xybA:
34.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  94
HIS A  96
HIS A 401
HIS A 403
 CU  A 703 (-3.0A)
CU  A 702 ( 3.2A)
CU  A 703 (-3.4A)
CU  A 701 ( 3.1A)
 0.43A 3qpkA-3abgA:
26.6		 3qpkA-3abgA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 401
HIS A 403
HIS A  94
HIS A  96
 CU  A 703 (-3.4A)
CU  A 701 ( 3.1A)
CU  A 703 (-3.0A)
CU  A 702 ( 3.2A)
 0.97A 3qpkA-3abgA:
26.6		 3qpkA-3abgA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.16A 3qpkA-3aw5A:
27.6		 3qpkA-3aw5A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.85A 3qpkA-3aw5A:
27.6		 3qpkA-3aw5A:
26.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  93
HIS A  95
HIS A 434
HIS A 436
 CU  A 604 (-3.1A)
CU  A 603 ( 3.2A)
CU  A 604 (-3.2A)
CU  A 602 (-3.2A)
 0.16A 3qpkA-3dkhA:
66.0		 3qpkA-3dkhA:
99.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 434
HIS A 436
HIS A  93
HIS A  95
 CU  A 604 (-3.2A)
CU  A 602 (-3.2A)
CU  A 604 (-3.1A)
CU  A 603 ( 3.2A)
 0.85A 3qpkA-3dkhA:
66.0		 3qpkA-3dkhA:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.26A 3qpkA-3gyrA:
22.4		 3qpkA-3gyrA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.88A 3qpkA-3gyrA:
22.4		 3qpkA-3gyrA:
25.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 403
HIS A 405
 CU  A 602 (-3.1A)
CU  A 604 ( 2.9A)
CU  A 602 (-3.0A)
CU  A 603 ( 3.0A)
 0.38A 3qpkA-3kw7A:
42.1		 3qpkA-3kw7A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A  64
HIS A 405
HIS A 455
 CU  A 603 (-3.2A)
CU  A 602 (-3.1A)
CU  A 603 ( 3.0A)
CU  A 603 (-3.1A)
 1.35A 3qpkA-3kw7A:
42.1		 3qpkA-3kw7A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 403
HIS A 405
HIS A  64
HIS A  66
 CU  A 602 (-3.0A)
CU  A 603 ( 3.0A)
CU  A 602 (-3.1A)
CU  A 604 ( 2.9A)
 0.92A 3qpkA-3kw7A:
42.1		 3qpkA-3kw7A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 455
HIS A 403
HIS A 405
HIS A 111
 CU  A 603 (-3.1A)
CU  A 602 (-3.0A)
CU  A 603 ( 3.0A)
CU  A 603 (-3.2A)
 1.26A 3qpkA-3kw7A:
42.1		 3qpkA-3kw7A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  94
HIS A  96
HIS A 435
HIS A 437
 CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 604 ( 3.3A)
CU  A 602 (-3.3A)
 0.21A 3qpkA-3ppsA:
62.3		 3qpkA-3ppsA:
75.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 435
HIS A 437
HIS A  94
HIS A  96
 CU  A 604 ( 3.3A)
CU  A 602 (-3.3A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
 0.79A 3qpkA-3ppsA:
62.3		 3qpkA-3ppsA:
75.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 398
HIS A 400
 CU  A1502 ( 3.0A)
CU  A1501 ( 3.0A)
CU  A1502 ( 2.9A)
CU  A1500 ( 3.2A)
 0.39A 3qpkA-3pxlA:
42.8		 3qpkA-3pxlA:
32.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A  64
HIS A 400
HIS A 452
 CU  A1500 (-3.2A)
CU  A1502 ( 3.0A)
CU  A1500 ( 3.2A)
CU  A1500 (-3.1A)
 1.35A 3qpkA-3pxlA:
42.8		 3qpkA-3pxlA:
32.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A  64
HIS A  66
 CU  A1502 ( 2.9A)
CU  A1500 ( 3.2A)
CU  A1502 ( 3.0A)
CU  A1501 ( 3.0A)
 0.88A 3qpkA-3pxlA:
42.8		 3qpkA-3pxlA:
32.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 452
HIS A 398
HIS A 400
HIS A 111
 CU  A1500 (-3.1A)
CU  A1502 ( 2.9A)
CU  A1500 ( 3.2A)
CU  A1500 (-3.2A)
 1.31A 3qpkA-3pxlA:
42.8		 3qpkA-3pxlA:
32.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  65
HIS A  67
HIS A 400
HIS A 402
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.2A)
 0.22A 3qpkA-3t6wA:
42.7		 3qpkA-3t6wA:
31.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 112
HIS A  65
HIS A 402
HIS A 452
 CU  A 503 (-3.4A)
CU  A 504 (-3.1A)
CU  A 503 ( 3.2A)
CU  A 503 ( 3.3A)
 1.35A 3qpkA-3t6wA:
42.7		 3qpkA-3t6wA:
31.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 400
HIS A 402
HIS A  65
HIS A  67
 CU  A 504 ( 3.1A)
CU  A 503 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
 0.84A 3qpkA-3t6wA:
42.7		 3qpkA-3t6wA:
31.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  87
HIS A  89
HIS A 429
HIS A 431
 CU  A 602 ( 4.7A)
CU  A 603 (-2.9A)
CU  A 602 (-3.6A)
CU  A 602 (-3.1A)
 0.45A 3qpkA-3v9eA:
52.2		 3qpkA-3v9eA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 133
HIS A  87
HIS A 429
HIS A 488
 CU  A 602 (-3.3A)
CU  A 602 ( 4.7A)
CU  A 602 (-3.6A)
CU  A 602 (-3.1A)
 1.17A 3qpkA-3v9eA:
52.2		 3qpkA-3v9eA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 133
HIS A  87
HIS A 431
HIS A 488
 CU  A 602 (-3.3A)
CU  A 602 ( 4.7A)
CU  A 602 (-3.1A)
CU  A 602 (-3.1A)
 1.30A 3qpkA-3v9eA:
52.2		 3qpkA-3v9eA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 488
HIS A 429
HIS A 431
HIS A 133
 CU  A 602 (-3.1A)
CU  A 602 (-3.6A)
CU  A 602 (-3.1A)
CU  A 602 (-3.3A)
 1.35A 3qpkA-3v9eA:
52.2		 3qpkA-3v9eA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  85
HIS A  87
HIS A 420
HIS A 422
 CU  A 614 (-3.1A)
CU  A 615 ( 3.1A)
CU  A 614 (-3.1A)
CU  A 616 ( 3.2A)
 0.26A 3qpkA-3x1bA:
42.8		 3qpkA-3x1bA:
32.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 420
HIS A 422
HIS A  85
HIS A  87
 CU  A 614 (-3.1A)
CU  A 616 ( 3.2A)
CU  A 614 (-3.1A)
CU  A 615 ( 3.1A)
 0.87A 3qpkA-3x1bA:
42.8		 3qpkA-3x1bA:
32.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 474
HIS A 420
HIS A 422
HIS A 132
 CU  A 616 (-3.2A)
CU  A 614 (-3.1A)
CU  A 616 ( 3.2A)
CU  A 616 (-3.2A)
 1.35A 3qpkA-3x1bA:
42.8		 3qpkA-3x1bA:
32.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 139
HIS A 141
HIS A 442
HIS A 444
 CU  A 604 ( 3.0A)
CU  A 602 (-3.0A)
CU  A 604 ( 3.0A)
CU  A 603 (-3.1A)
 0.31A 3qpkA-3zx1A:
27.9		 3qpkA-3zx1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 442
HIS A 444
HIS A 139
HIS A 141
 CU  A 604 ( 3.0A)
CU  A 603 (-3.1A)
CU  A 604 ( 3.0A)
CU  A 602 (-3.0A)
 0.86A 3qpkA-3zx1A:
27.9		 3qpkA-3zx1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 494
HIS A 442
HIS A 444
HIS A 182
 CU  A 603 ( 3.1A)
CU  A 604 ( 3.0A)
CU  A 603 (-3.1A)
CU  A 603 ( 2.8A)
 1.27A 3qpkA-3zx1A:
27.9		 3qpkA-3zx1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 105
HIS A 107
HIS A 422
HIS A 424
 CU  A 604 ( 3.1A)
CU  A 602 (-3.1A)
CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
 0.24A 3qpkA-4akoA:
26.8		 3qpkA-4akoA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 155
HIS A 105
HIS A 424
HIS A 491
 CU  A 603 ( 3.2A)
CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
CU  A 603 ( 3.1A)
 1.35A 3qpkA-4akoA:
26.8		 3qpkA-4akoA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 422
HIS A 424
HIS A 105
HIS A 107
 CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
CU  A 604 ( 3.1A)
CU  A 602 (-3.1A)
 0.80A 3qpkA-4akoA:
26.8		 3qpkA-4akoA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 491
HIS A 422
HIS A 424
HIS A 155
 CU  A 603 ( 3.1A)
CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
CU  A 603 ( 3.2A)
 1.34A 3qpkA-4akoA:
26.8		 3qpkA-4akoA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 179
HIS A  69
HIS A 210
HIS A 209
 CUO  A9001 (-3.4A)
CUO  A9001 (-3.1A)
CUO  A9001 (-3.3A)
None
 1.34A 3qpkA-4bedA:
undetectable		 3qpkA-4bedA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  82
HIS A  84
HIS A 376
HIS A 378
 None
 0.41A 3qpkA-4f7kA:
27.7		 3qpkA-4f7kA:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 376
HIS A 378
HIS A  82
HIS A  84
 None
 0.85A 3qpkA-4f7kA:
27.7		 3qpkA-4f7kA:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7h PEROXIDE STRESS
SENSING REGULATOR

(Streptococcus
pyogenes) 		PF01475
(FUR) 		4 HIS A  99
HIS A   6
HIS A  19
HIS A  97
 NI  A 201 (-3.5A)
NI  A 201 (-3.6A)
NI  A 201 (-3.5A)
NI  A 201 (-3.6A)
 1.26A 3qpkA-4i7hA:
undetectable		 3qpkA-4i7hA:
11.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 397
HIS A 399
 CU  A 504 ( 2.8A)
CU  A 502 ( 3.1A)
CU  A 504 (-2.7A)
CU  A 501 ( 3.2A)
 0.38A 3qpkA-4jhvA:
42.5		 3qpkA-4jhvA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 397
HIS A 399
HIS A  64
HIS A  66
 CU  A 504 (-2.7A)
CU  A 501 ( 3.2A)
CU  A 504 ( 2.8A)
CU  A 502 ( 3.1A)
 0.91A 3qpkA-4jhvA:
42.5		 3qpkA-4jhvA:
32.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		4 HIS A 297
HIS A 298
HIS A 157
HIS A 121
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
 1.27A 3qpkA-4ymkA:
undetectable		 3qpkA-4ymkA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 HIS A 301
HIS A 302
HIS A 161
HIS A 125
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
 1.27A 3qpkA-4zyoA:
undetectable		 3qpkA-4zyoA:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 398
HIS A 400
 CU  A 509 (-3.2A)
CU  A 508 ( 3.1A)
CU  A 509 ( 3.1A)
CU  A 507 ( 3.1A)
 0.29A 3qpkA-5ehfA:
42.6		 3qpkA-5ehfA:
31.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 109
HIS A 111
HIS A 450
HIS A 452
 CU  A 508 (-3.3A)
CU  A 507 ( 3.3A)
CU  A 507 (-3.2A)
CU  A 508 (-3.2A)
 1.27A 3qpkA-5ehfA:
42.6		 3qpkA-5ehfA:
31.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A  64
HIS A 400
HIS A 450
 CU  A 507 ( 3.3A)
CU  A 509 (-3.2A)
CU  A 507 ( 3.1A)
CU  A 507 (-3.2A)
 1.35A 3qpkA-5ehfA:
42.6		 3qpkA-5ehfA:
31.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A  64
HIS A  66
 CU  A 509 ( 3.1A)
CU  A 507 ( 3.1A)
CU  A 509 (-3.2A)
CU  A 508 ( 3.1A)
 0.90A 3qpkA-5ehfA:
42.6		 3qpkA-5ehfA:
31.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 450
HIS A 398
HIS A 400
HIS A 111
 CU  A 507 (-3.2A)
CU  A 509 ( 3.1A)
CU  A 507 ( 3.1A)
CU  A 507 ( 3.3A)
 1.34A 3qpkA-5ehfA:
42.6		 3qpkA-5ehfA:
31.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 450
HIS A 452
HIS A 109
HIS A 111
 CU  A 507 (-3.2A)
CU  A 508 (-3.2A)
CU  A 508 (-3.3A)
CU  A 507 ( 3.3A)
 1.24A 3qpkA-5ehfA:
42.6		 3qpkA-5ehfA:
31.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  95
HIS A  97
HIS A 396
HIS A 398
 CU  A1463 (-4.1A)
CU  A1465 (-3.1A)
CU  A1463 ( 4.8A)
CU  A1463 (-2.9A)
 0.35A 3qpkA-5g3fA:
30.4		 3qpkA-5g3fA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  95
HIS A 137
HIS A 444
HIS A 396
 CU  A1463 (-4.1A)
CU  A1463 (-3.3A)
CU  A1463 (-3.0A)
CU  A1463 ( 4.8A)
 1.20A 3qpkA-5g3fA:
30.4		 3qpkA-5g3fA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 396
HIS A 398
HIS A  95
HIS A  97
 CU  A1463 ( 4.8A)
CU  A1463 (-2.9A)
CU  A1463 (-4.1A)
CU  A1465 (-3.1A)
 0.84A 3qpkA-5g3fA:
30.4		 3qpkA-5g3fA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 444
HIS A 396
HIS A  95
HIS A 137
 CU  A1463 (-3.0A)
CU  A1463 ( 4.8A)
CU  A1463 (-4.1A)
CU  A1463 (-3.3A)
 1.12A 3qpkA-5g3fA:
30.4		 3qpkA-5g3fA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 444
HIS A 396
HIS A 398
HIS A 137
 CU  A1463 (-3.0A)
CU  A1463 ( 4.8A)
CU  A1463 (-2.9A)
CU  A1463 (-3.3A)
 1.18A 3qpkA-5g3fA:
30.4		 3qpkA-5g3fA:
24.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 108
HIS A 110
HIS A 451
HIS A 453
 CU  A 603 ( 3.1A)
CU  A 601 (-2.9A)
CU  A 603 (-2.8A)
CU  A 602 (-3.1A)
 0.24A 3qpkA-5lm8A:
49.4		 3qpkA-5lm8A:
37.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 154
HIS A 108
HIS A 453
HIS A 515
 CU  A 602 ( 3.4A)
CU  A 603 ( 3.1A)
CU  A 602 (-3.1A)
CU  A 602 ( 3.2A)
 1.33A 3qpkA-5lm8A:
49.4		 3qpkA-5lm8A:
37.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 451
HIS A 453
HIS A 108
HIS A 110
 CU  A 603 (-2.8A)
CU  A 602 (-3.1A)
CU  A 603 ( 3.1A)
CU  A 601 (-2.9A)
 0.91A 3qpkA-5lm8A:
49.4		 3qpkA-5lm8A:
37.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  65
HIS A  67
HIS A 400
HIS A 402
 CU  A 503 (-3.1A)
CU  A 502 ( 2.9A)
CU  A 503 ( 3.1A)
CU  A 501 (-3.2A)
 0.21A 3qpkA-5mewA:
42.4		 3qpkA-5mewA:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 400
HIS A 402
HIS A  65
HIS A  67
 CU  A 503 ( 3.1A)
CU  A 501 (-3.2A)
CU  A 503 (-3.1A)
CU  A 502 ( 2.9A)
 0.80A 3qpkA-5mewA:
42.4		 3qpkA-5mewA:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A 101
HIS A 103
HIS A 972
HIS A 974
 CU  A1105 (-3.1A)
CU  A1104 ( 3.5A)
CU  A1105 (-3.3A)
CU  A1101 ( 3.2A)
 0.60A 3qpkA-5n4lA:
11.0		 3qpkA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A 972
HIS A 974
HIS A 101
HIS A 103
 CU  A1105 (-3.3A)
CU  A1101 ( 3.2A)
CU  A1105 (-3.1A)
CU  A1104 ( 3.5A)
 0.75A 3qpkA-5n4lA:
11.0		 3qpkA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A  91
HIS A  93
HIS A 437
HIS A 439
 EDO  A 602 ( 4.5A)
None
None
EDO  A 602 (-3.8A)
 0.50A 3qpkA-6evgA:
28.4		 3qpkA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A  91
HIS A 133
HIS A 489
HIS A 437
 EDO  A 602 ( 4.5A)
EDO  A 602 (-4.1A)
None
None
 1.16A 3qpkA-6evgA:
28.4		 3qpkA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A 437
HIS A 439
HIS A  91
HIS A  93
 None
EDO  A 602 (-3.8A)
EDO  A 602 ( 4.5A)
None
 0.91A 3qpkA-6evgA:
28.4		 3qpkA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A 489
HIS A 437
HIS A  91
HIS A 133
 None
None
EDO  A 602 ( 4.5A)
EDO  A 602 (-4.1A)
 1.13A 3qpkA-6evgA:
28.4		 3qpkA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A 489
HIS A 437
HIS A 439
HIS A 133
 None
None
EDO  A 602 (-3.8A)
EDO  A 602 (-4.1A)
 1.14A 3qpkA-6evgA:
28.4		 3qpkA-6evgA:
undetectable