SIMILAR PATTERNS OF AMINO ACIDS FOR 3QPK_A_CUA601_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 445
CYH A 507
ILE A 509
HIS A 512
 CU  A 554 (-3.2A)
CU  A 554 (-2.1A)
CU  A 554 ( 4.1A)
CU  A 554 (-3.1A)
 0.32A 3qpkA-1asoA:
38.6		 3qpkA-1asoA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2i FUSION OF N-TERMINAL
17-MER PEPTIDE
EXTENSION TO ZIF12

(Mus musculus) 		PF00096
(zf-C2H2) 		4 HIS G1153
CYH G1137
ILE G1139
HIS G1157
 ZN  G1202 (-3.3A)
ZN  G1202 (-2.4A)
ZN  G1202 ( 4.6A)
ZN  G1202 (-3.3A)
 1.42A 3qpkA-1f2iG:
undetectable		 3qpkA-1f2iG:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhq PROTEIN KINASE SPK1

(Saccharomyces
cerevisiae) 		PF00498
(FHA) 		4 HIS A 651
CYH A 623
ILE A 680
HIS A 622
 None
 1.30A 3qpkA-1fhqA:
undetectable		 3qpkA-1fhqA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g2d TATA BOX ZINC FINGER
PROTEIN

(Mus musculus) 		PF00096
(zf-C2H2)
PF13894
(zf-C2H2_4) 		4 HIS C 181
CYH C 165
ILE C 167
HIS C 185
 ZN  C 303 (-3.3A)
ZN  C 303 (-2.4A)
ZN  C 303 ( 4.9A)
ZN  C 303 (-3.2A)
 1.47A 3qpkA-1g2dC:
undetectable		 3qpkA-1g2dC:
7.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 395
CYH A 453
ILE A 455
HIS A 458
 CU  A1503 (-3.1A)
CU  A1503 (-2.1A)
CU  A1503 ( 3.8A)
CU  A1503 (-3.1A)
 0.34A 3qpkA-1gycA:
42.8		 3qpkA-1gycA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 396
CYH A 452
ILE A 454
HIS A 457
LEU A 462
 CU  A 701 (-3.2A)
CU  A 701 (-2.1A)
CU  A 701 ( 3.8A)
CU  A 701 (-3.1A)
CU  A 701 (-4.9A)
 0.29A 3qpkA-1hfuA:
41.2		 3qpkA-1hfuA:
31.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 276
CYH A 319
HIS A 324
LEU A 329
 CU  A1049 ( 3.1A)
CU  A1049 ( 2.0A)
CU  A1049 ( 3.1A)
CU  A1049 (-4.7A)
 0.53A 3qpkA-1kcwA:
8.0		 3qpkA-1kcwA:
19.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 395
CYH A 453
ILE A 455
HIS A 458
 CU  A 500 (-3.4A)
CU  A 500 (-2.2A)
CU  A 500 (-3.7A)
CU  A 500 ( 3.3A)
 0.36A 3qpkA-1kyaA:
42.9		 3qpkA-1kyaA:
34.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llm CHIMERA OF
ZIF23-GCN4

(Saccharomyces
cerevisiae;
Mus musculus) 		PF00096
(zf-C2H2) 		4 HIS C 150
CYH C 134
ILE C 136
HIS C 155
 ZN  C 302 (-3.3A)
ZN  C 302 (-2.3A)
None
ZN  C 302 (-3.3A)
 1.49A 3qpkA-1llmC:
undetectable		 3qpkA-1llmC:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q18 GLUCOKINASE

(Escherichia
coli) 		PF02685
(Glucokinase) 		4 CYH A  60
ILE A  98
HIS A 312
LEU A 313
 None
 0.98A 3qpkA-1q18A:
undetectable		 3qpkA-1q18A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)

(Burkholderia
glumae;
Burkholderia
glumae) 		PF00561
(Abhydrolase_1)
no annotation 		4 HIS E 285
ILE E 289
HIS D  86
LEU D  17
 None
 1.22A 3qpkA-1qgeE:
undetectable		 3qpkA-1qgeE:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcy RUSTICYANIN

(Acidithiobacillus
ferrooxidans) 		PF00127
(Copper-bind) 		4 HIS A  85
CYH A 138
ILE A 140
HIS A 143
 CU  A 156 ( 3.1A)
CU  A 156 ( 2.2A)
CU  A 156 ( 4.1A)
CU  A 156 ( 3.0A)
 0.72A 3qpkA-1rcyA:
9.3		 3qpkA-1rcyA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srk ZINC FINGER PROTEIN
ZFPM1

(Mus musculus) 		no annotation 4 HIS A  26
CYH A  10
ILE A  12
HIS A  30
 ZN  A  36 (-3.2A)
ZN  A  36 (-2.2A)
None
ZN  A  36 (-3.2A)
 1.40A 3qpkA-1srkA:
undetectable		 3qpkA-1srkA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tah LIPASE

(Burkholderia
glumae) 		no annotation 4 HIS B 285
ILE B 289
HIS B  86
LEU B  17
 None
 1.24A 3qpkA-1tahB:
undetectable		 3qpkA-1tahB:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 396
CYH A 452
ILE A 454
HIS A 457
LEU A 462
 CU  A1503 (-3.2A)
CU  A1503 (-2.1A)
CU  A1503 (-3.4A)
CU  A1503 (-3.2A)
None
 0.34A 3qpkA-1v10A:
42.3		 3qpkA-1v10A:
32.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1va1 TRANSCRIPTION FACTOR
SP1

(Homo sapiens) 		no annotation 4 HIS A 557
CYH A 539
ILE A 541
HIS A 561
 ZN  A 100 (-3.1A)
ZN  A 100 (-2.3A)
None
ZN  A 100 (-3.2A)
 1.48A 3qpkA-1va1A:
undetectable		 3qpkA-1va1A:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A  49
CYH A 116
ILE A 118
HIS A 119
 FE  A1129 ( 3.4A)
FE  A1129 (-2.7A)
None
FE  A1129 ( 3.2A)
 1.34A 3qpkA-1vzhA:
undetectable		 3qpkA-1vzhA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A  69
CYH A 116
ILE A 118
HIS A 119
 FE  A1129 ( 3.4A)
FE  A1129 (-2.7A)
None
FE  A1129 ( 3.2A)
 1.25A 3qpkA-1vzhA:
undetectable		 3qpkA-1vzhA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ws7 MAVICYANIN

(Cucurbita pepo) 		PF02298
(Cu_bind_like) 		4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.61A 3qpkA-1ws7A:
2.5		 3qpkA-1ws7A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4j RING FINGER PROTEIN
38

(Homo sapiens) 		PF13639
(zf-RING_2) 		4 CYH A  63
ILE A  65
HIS A  46
LEU A  42
 ZN  A 401 (-2.3A)
ZN  A 401 ( 4.3A)
ZN  A 401 (-3.0A)
None
 1.41A 3qpkA-1x4jA:
undetectable		 3qpkA-1x4jA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zaa PROTEIN (ZIF268)

(Mus musculus) 		PF00096
(zf-C2H2) 		4 HIS C  53
CYH C  37
ILE C  39
HIS C  57
 ZN  C 202 (-3.2A)
ZN  C 202 (-2.3A)
ZN  C 202 ( 4.8A)
ZN  C 202 (-3.2A)
 1.39A 3qpkA-1zaaC:
undetectable		 3qpkA-1zaaC:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 413
CYH A 484
ILE A 486
HIS A 489
LEU A 494
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
None
 0.41A 3qpkA-1zpuA:
40.6		 3qpkA-1zpuA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct1 TRANSCRIPTIONAL
REPRESSOR CTCF

(Homo sapiens) 		PF00096
(zf-C2H2) 		4 HIS A  34
CYH A  18
ILE A  20
HIS A  39
 ZN  A 201 (-3.4A)
ZN  A 201 (-2.3A)
ZN  A 201 ( 4.2A)
ZN  A 201 (-3.4A)
 1.45A 3qpkA-2ct1A:
undetectable		 3qpkA-2ct1A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct5 ZINC FINGER BED
DOMAIN CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02892
(zf-BED) 		4 HIS A  51
CYH A  32
ILE A  34
HIS A  56
 ZN  A 201 (-3.5A)
ZN  A 201 (-2.3A)
ZN  A 201 ( 4.3A)
ZN  A 201 (-3.4A)
 1.47A 3qpkA-2ct5A:
undetectable		 3qpkA-2ct5A:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dv6 NITRITE REDUCTASE

(Hyphomicrobium
denitrificans) 		PF07732
(Cu-oxidase_3) 		4 HIS A  77
CYH A 114
ILE A 116
HIS A 119
 CU  A 502 (-3.2A)
CU  A 502 (-2.2A)
CU  A 502 ( 4.6A)
CU  A 502 (-3.1A)
 0.68A 3qpkA-2dv6A:
6.7		 3qpkA-2dv6A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecn RING FINGER PROTEIN
141

(Homo sapiens) 		PF13920
(zf-C3HC4_3) 		4 CYH A  51
ILE A  53
HIS A  34
LEU A  30
 ZN  A 401 (-2.2A)
ZN  A 401 ( 4.9A)
ZN  A 401 (-3.1A)
ZN  A 401 ( 4.9A)
 1.30A 3qpkA-2ecnA:
undetectable		 3qpkA-2ecnA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eoq ZINC FINGER PROTEIN
224

(Homo sapiens) 		no annotation 4 HIS A  31
CYH A  15
ILE A  17
HIS A  35
 ZN  A 201 ( 3.2A)
ZN  A 201 ( 2.3A)
ZN  A 201 ( 4.2A)
ZN  A 201 ( 3.1A)
 1.43A 3qpkA-2eoqA:
undetectable		 3qpkA-2eoqA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eos B-CELL LYMPHOMA 6
PROTEIN

(Homo sapiens) 		PF00096
(zf-C2H2) 		4 HIS A  30
CYH A  14
ILE A  16
HIS A  34
 ZN  A 201 ( 3.2A)
ZN  A 201 ( 2.3A)
ZN  A 201 ( 4.1A)
ZN  A 201 ( 3.1A)
 1.33A 3qpkA-2eosA:
undetectable		 3qpkA-2eosA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epr POZ-, AT HOOK-, AND
ZINC
FINGER-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 4 HIS A 373
CYH A 357
ILE A 359
HIS A 377
 ZN  A 201 ( 3.2A)
ZN  A 201 (-2.3A)
ZN  A 201 (-4.3A)
ZN  A 201 ( 3.1A)
 1.44A 3qpkA-2eprA:
undetectable		 3qpkA-2eprA:
5.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 395
CYH A 453
ILE A 455
HIS A 458
 CU  A 601 (-3.6A)
CU  A 601 (-2.1A)
CU  A 601 (-3.7A)
CU  A 601 (-3.4A)
 0.42A 3qpkA-2hzhA:
43.0		 3qpkA-2hzhA:
31.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsp TRANSCRIPTIONAL
REGULATORY PROTEIN
ROS

(Agrobacterium
tumefaciens) 		PF05443
(ROS_MUCR) 		4 HIS A  42
CYH A  24
HIS A  37
LEU A  34
 None
 1.36A 3qpkA-2jspA:
undetectable		 3qpkA-2jspA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m0f ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17

(Homo sapiens) 		PF00096
(zf-C2H2) 		4 HIS A  82
CYH A  62
HIS A  78
LEU A  79
 ZN  A 201 (-3.1A)
ZN  A 201 (-2.3A)
ZN  A 201 (-3.1A)
None
 1.39A 3qpkA-2m0fA:
undetectable		 3qpkA-2m0fA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9a E3 UBIQUITIN-PROTEIN
LIGASE ZFP91

(Homo sapiens) 		PF00096
(zf-C2H2) 		4 HIS A  90
CYH A  74
ILE A  76
HIS A  95
 ZN  A 103 (-3.2A)
ZN  A 103 (-2.3A)
ZN  A 103 ( 4.8A)
ZN  A 103 (-3.3A)
 1.49A 3qpkA-2m9aA:
undetectable		 3qpkA-2m9aA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mq1 E3 UBIQUITIN-PROTEIN
LIGASE HAKAI

(Mus musculus) 		no annotation 4 HIS A  80
CYH A  61
ILE A  63
HIS A  85
 ZN  A 103 (-3.1A)
ZN  A 103 (-2.3A)
ZN  A 103 ( 4.9A)
ZN  A 103 (-2.9A)
 1.41A 3qpkA-2mq1A:
undetectable		 3qpkA-2mq1A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mxp CALCIUM-BINDING AND
COILED-COIL
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		no annotation 4 HIS A  75
CYH A  57
ILE A  59
HIS A  79
 ZN  A 101 (-3.2A)
ZN  A 101 (-2.3A)
ZN  A 101 ( 4.3A)
ZN  A 101 (-3.1A)
 1.41A 3qpkA-2mxpA:
undetectable		 3qpkA-2mxpA:
4.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 394
CYH A 452
ILE A 454
HIS A 457
 CU  A 499 (-3.1A)
CU  A 499 (-2.2A)
CU  A 499 (-3.7A)
CU  A 499 (-3.1A)
 0.32A 3qpkA-2qt6A:
42.8		 3qpkA-2qt6A:
31.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7e COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2404 (-3.2A)
CU  B2404 (-2.2A)
CU  B2404 (-2.6A)
CU  B2404 (-3.5A)
 0.98A 3qpkA-2r7eB:
7.7		 3qpkA-2r7eB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		4 HIS D 555
ILE D 539
HIS D 569
LEU D 534
 None
 1.46A 3qpkA-2vnuD:
undetectable		 3qpkA-2vnuD:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN

(Bacteroides
fragilis) 		PF00210
(Ferritin) 		4 HIS A 141
ILE A 142
HIS A  65
LEU A  68
 None
None
FE  A6204 (-3.3A)
None
 1.26A 3qpkA-2vzbA:
undetectable		 3qpkA-2vzbA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 HIS B 483
ILE B 513
HIS B 493
LEU B 492
 None
None
None
XAX  B1778 (-3.9A)
 1.23A 3qpkA-2w55B:
undetectable		 3qpkA-2w55B:
20.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 395
CYH A 451
ILE A 453
HIS A 456
 CU  A 501 (-3.1A)
CU  A 501 (-2.2A)
CU  A 501 (-3.7A)
CU  A 501 ( 3.1A)
 0.32A 3qpkA-2xybA:
43.0		 3qpkA-2xybA:
34.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yt9 ZINC
FINGER-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00096
(zf-C2H2)
PF13894
(zf-C2H2_4) 		4 HIS A 380
CYH A 364
ILE A 366
HIS A 384
 ZN  A 201 (-3.2A)
ZN  A 201 (-2.3A)
ZN  A 201 ( 4.0A)
ZN  A 201 (-3.1A)
 1.44A 3qpkA-2yt9A:
undetectable		 3qpkA-2yt9A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znv AMSH-LIKE PROTEASE

(Homo sapiens) 		PF01398
(JAB) 		4 HIS A 310
CYH A 298
ILE A 312
LEU A 340
 None
 0.98A 3qpkA-2znvA:
undetectable		 3qpkA-2znvA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 2

(Mus musculus) 		PF00169
(PH) 		4 HIS A 614
CYH A 694
ILE A 572
LEU A 704
 None
 1.37A 3qpkA-3a8pA:
undetectable		 3qpkA-3a8pA:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 431
CYH A 503
ILE A 505
HIS A 508
LEU A 513
 CU  A 601 (-3.0A)
CU  A 601 (-2.1A)
CU  A 601 ( 4.0A)
CU  A 601 (-3.3A)
CU  A 601 ( 4.6A)
 0.15A 3qpkA-3dkhA:
66.0		 3qpkA-3dkhA:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 HIS A 943
ILE A 942
HIS A 924
LEU A 946
 CL  A   5 ( 4.8A)
CL  A   5 ( 4.9A)
CL  A   5 (-4.0A)
None
 1.22A 3qpkA-3fawA:
2.0		 3qpkA-3fawA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdc MULTICOPPER OXIDASE

(Arthrobacter
sp. FB24) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  99
CYH A 144
HIS A 152
LEU A 157
 CU  A 301 (-3.1A)
CU  A 301 (-2.1A)
CU  A 301 (-3.2A)
CU  A 301 (-4.6A)
 0.71A 3qpkA-3gdcA:
22.8		 3qpkA-3gdcA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)

(Corynebacterium
glutamicum) 		PF13377
(Peripla_BP_3) 		4 HIS A 170
CYH A 327
ILE A 267
LEU A 174
 None
 1.32A 3qpkA-3gybA:
undetectable		 3qpkA-3gybA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuf ZINC FINGER PROTEIN
UBI-D4

(Homo sapiens) 		no annotation 4 HIS A 227
CYH A 211
ILE A 213
HIS A 232
 ZN  A   1 (-3.2A)
ZN  A   1 (-2.3A)
ZN  A   1 ( 4.9A)
ZN  A   1 (-3.3A)
 1.45A 3qpkA-3iufA:
undetectable		 3qpkA-3iufA:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 None
 0.37A 3qpkA-3j2sB:
10.8		 3qpkA-3j2sB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1l FANCL

(Drosophila
melanogaster) 		no annotation 4 HIS B 278
CYH B 207
ILE B 203
LEU B 206
 None
 1.42A 3qpkA-3k1lB:
undetectable		 3qpkA-3k1lB:
19.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 400
CYH A 456
ILE A 458
HIS A 461
 CU  A 601 (-3.2A)
CU  A 601 (-2.1A)
CU  A 601 (-3.7A)
CU  A 601 (-3.1A)
 0.38A 3qpkA-3kw7A:
42.1		 3qpkA-3kw7A:
32.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF02815
(MIR) 		4 HIS A 177
CYH A 192
ILE A 194
HIS A 175
 None
 1.25A 3qpkA-3malA:
undetectable		 3qpkA-3malA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odj RHOMBOID PROTEASE
GLPG

(Haemophilus
influenzae) 		PF01694
(Rhomboid) 		4 HIS A  65
ILE A  66
HIS A  60
LEU A  61
 None
 1.32A 3qpkA-3odjA:
undetectable		 3qpkA-3odjA:
15.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 432
CYH A 504
ILE A 506
HIS A 509
LEU A 514
 CU  A 601 (-3.1A)
CU  A 601 (-2.1A)
CU  A 601 ( 4.1A)
CU  A 601 (-3.1A)
CU  A 601 ( 4.7A)
 0.15A 3qpkA-3ppsA:
62.3		 3qpkA-3ppsA:
75.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 395
CYH A 453
ILE A 455
HIS A 458
 CU  A1503 (-3.1A)
CU  A1503 (-2.1A)
CU  A1503 (-3.7A)
CU  A1503 (-3.1A)
 0.31A 3qpkA-3pxlA:
42.8		 3qpkA-3pxlA:
32.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6z POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		PF01661
(Macro) 		4 HIS A 829
CYH A 849
HIS A 879
LEU A 827
 None
 1.47A 3qpkA-3q6zA:
undetectable		 3qpkA-3q6zA:
17.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 397
CYH A 453
ILE A 455
HIS A 458
 CU  A 501 (-3.1A)
CU  A 501 (-2.0A)
CU  A 501 (-3.8A)
CU  A 501 (-3.3A)
 0.31A 3qpkA-3t6wA:
42.7		 3qpkA-3t6wA:
31.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 426
CYH A 489
ILE A 491
HIS A 494
 CU  A 601 (-3.1A)
CU  A 601 (-2.2A)
CU  A 601 (-4.0A)
CU  A 601 (-3.1A)
 0.30A 3qpkA-3v9eA:
52.2		 3qpkA-3v9eA:
37.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0f ENDONUCLEASE 8-LIKE
3

(Mus musculus) 		PF06831
(H2TH) 		4 HIS A 246
CYH A 236
ILE A 243
LEU A 232
 None
 1.40A 3qpkA-3w0fA:
undetectable		 3qpkA-3w0fA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4k D-AMINO-ACID OXIDASE

(Homo sapiens) 		PF01266
(DAO) 		4 HIS A 311
CYH A 322
ILE A 318
LEU A 291
 None
 1.38A 3qpkA-3w4kA:
undetectable		 3qpkA-3w4kA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5k ZINC FINGER PROTEIN
SNAI1

(Homo sapiens) 		PF00096
(zf-C2H2)
PF13912
(zf-C2H2_6) 		4 HIS B 212
CYH B 210
HIS B 230
LEU B 227
 None
ZN  B 503 (-2.4A)
ZN  B 503 (-3.2A)
None
 1.25A 3qpkA-3w5kB:
undetectable		 3qpkA-3w5kB:
18.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 417
CYH A 475
ILE A 477
HIS A 480
 CU  A 617 (-3.1A)
CU  A 617 (-2.2A)
CU  A 617 ( 3.8A)
CU  A 617 (-3.1A)
 0.29A 3qpkA-3x1bA:
42.8		 3qpkA-3x1bA:
32.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		4 HIS A 135
CYH A 275
ILE A 138
LEU A 298
 None
 1.45A 3qpkA-3zdpA:
undetectable		 3qpkA-3zdpA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 439
CYH A 495
ILE A 497
HIS A 500
 CU  A 601 (-3.1A)
CU  A 601 (-2.2A)
CU  A 601 ( 3.9A)
CU  A 601 (-3.1A)
 0.33A 3qpkA-3zx1A:
27.9		 3qpkA-3zx1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 419
CYH A 492
ILE A 494
HIS A 497
 CU  A 601 (-3.1A)
CU  A 601 (-2.2A)
CU  A 601 ( 4.0A)
CU  A 601 (-3.1A)
 0.29A 3qpkA-4akoA:
26.7		 3qpkA-4akoA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF04166
(PdxA) 		4 HIS A 291
ILE A 185
HIS A 187
LEU A 176
 None
 1.23A 3qpkA-4atyA:
undetectable		 3qpkA-4atyA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayc E3 UBIQUITIN-PROTEIN
LIGASE RNF8

(Homo sapiens) 		PF13920
(zf-C3HC4_3) 		4 CYH A 437
ILE A 439
HIS A 420
LEU A 416
 ZN  A1484 (-2.3A)
ZN  A1484 ( 4.8A)
ZN  A1484 (-3.1A)
None
 1.41A 3qpkA-4aycA:
undetectable		 3qpkA-4aycA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1

(Mus musculus) 		PF08447
(PAS_3) 		4 HIS A 364
CYH A 368
ILE A 493
HIS A 409
 None
 1.41A 3qpkA-4dj2A:
undetectable		 3qpkA-4dj2A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fai CG5976, ISOFORM B

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		4 HIS A 307
ILE A 305
HIS A 295
LEU A 226
 None
 1.44A 3qpkA-4faiA:
undetectable		 3qpkA-4faiA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh5 PUTATIVE TYPE VI
SECRETION PROTEIN

(Escherichia
coli) 		PF02861
(Clp_N) 		4 HIS A  42
CYH A  30
ILE A  38
LEU A  29
 None
 1.40A 3qpkA-4hh5A:
undetectable		 3qpkA-4hh5A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1t RNA-DIRECTED RNA
POLYMERASE L

(Cali
mammarenavirus) 		PF17296
(ArenaCapSnatch) 		4 HIS A  58
CYH A  60
ILE A  98
LEU A 100
 None
 1.20A 3qpkA-4i1tA:
undetectable		 3qpkA-4i1tA:
17.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 394
CYH A 450
ILE A 452
HIS A 455
 CU  A 503 (-3.1A)
CU  A 503 (-2.2A)
CU  A 503 (-3.7A)
CU  A 503 (-3.1A)
 0.30A 3qpkA-4jhvA:
42.5		 3qpkA-4jhvA:
32.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH) 		4 HIS A 543
CYH A 623
ILE A 501
LEU A 633
 None
 1.39A 3qpkA-4k2pA:
undetectable		 3qpkA-4k2pA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhp GLUTAMINYL CYCLASE,
PUTATIVE

(Ixodes
scapularis) 		PF04389
(Peptidase_M28) 		4 HIS A 311
ILE A 309
HIS A 299
LEU A 236
 None
 1.46A 3qpkA-4mhpA:
undetectable		 3qpkA-4mhpA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1j GU4 NUCLEIC-BINDING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF01588
(tRNA_bind) 		4 CYH A  45
ILE A  76
HIS A  22
LEU A  28
 None
 1.00A 3qpkA-4r1jA:
undetectable		 3qpkA-4r1jA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		4 HIS B 389
ILE B 392
HIS B 331
LEU B 334
 CLA  B1226 (-4.0A)
CLA  B1226 (-4.4A)
CLA  B1202 ( 3.8A)
CLA  B1202 ( 3.8A)
 1.50A 3qpkA-4rkuB:
undetectable		 3qpkA-4rkuB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 4 HIS A1798
CYH A1805
ILE A1804
LEU A1773
 ZN  A2408 (-3.3A)
ZN  A2408 (-2.3A)
ZN  A2408 ( 4.5A)
None
 1.34A 3qpkA-4uclA:
undetectable		 3qpkA-4uclA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3l E3 UBIQUITIN-PROTEIN
LIGASE RNF38

(Homo sapiens) 		PF13639
(zf-RING_2) 		4 CYH C 450
ILE C 452
HIS C 433
LEU C 429
 ZN  C1464 (-2.3A)
ZN  C1464 ( 4.8A)
ZN  C1464 (-3.1A)
None
 1.42A 3qpkA-4v3lC:
undetectable		 3qpkA-4v3lC:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.48A 3qpkA-5a31A:
undetectable		 3qpkA-5a31A:
16.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 395
CYH A 451
ILE A 453
HIS A 456
 CU  A 510 (-3.1A)
CU  A 510 (-2.0A)
CU  A 510 (-3.7A)
CU  A 510 (-3.1A)
 0.39A 3qpkA-5ehfA:
42.5		 3qpkA-5ehfA:
31.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 393
CYH A 445
ILE A 447
HIS A 450
 CU  A1464 (-3.1A)
CU  A1464 (-2.1A)
CU  A1464 ( 3.9A)
CU  A1464 (-3.2A)
 0.37A 3qpkA-5g3fA:
30.3		 3qpkA-5g3fA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itg SORBITOL
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 CYH A 306
ILE A 373
HIS A 302
LEU A 305
 None
 0.68A 3qpkA-5itgA:
undetectable		 3qpkA-5itgA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.62A 3qpkA-5k8dA:
8.0		 3qpkA-5k8dA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.53A 3qpkA-5k8dB:
5.0		 3qpkA-5k8dB:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 448
CYH A 516
ILE A 518
HIS A 521
 CU  A 604 (-3.1A)
CU  A 604 (-2.1A)
CU  A 604 (-3.8A)
CU  A 604 (-3.0A)
 0.23A 3qpkA-5lm8A:
49.4		 3qpkA-5lm8A:
37.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 397
CYH A 453
ILE A 455
HIS A 458
 CU  A 504 (-3.1A)
CU  A 504 (-2.1A)
CU  A 504 (-3.8A)
CU  A 504 (-3.1A)
 0.32A 3qpkA-5mewA:
42.4		 3qpkA-5mewA:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A 162
ILE A1021
HIS A1014
LEU A1012
 CU  A1101 (-3.3A)
None
CU  A1101 (-3.2A)
None
 1.33A 3qpkA-5n4lA:
11.0		 3qpkA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A 275
CYH A 318
HIS A 323
LEU A 328
 CU  A1103 (-3.3A)
CU  A1103 (-2.1A)
CU  A1103 (-3.0A)
CU  A1103 (-4.4A)
 0.53A 3qpkA-5n4lA:
11.0		 3qpkA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t00 TRANSCRIPTIONAL
REPRESSOR CTCF

(Homo sapiens) 		PF00096
(zf-C2H2)
PF13909
(zf-H2C2_5) 		4 HIS A 425
CYH A 409
ILE A 411
HIS A 430
 ZN  A 504 (-3.2A)
ZN  A 504 (-2.2A)
ZN  A 504 ( 4.8A)
ZN  A 504 (-3.1A)
 1.42A 3qpkA-5t00A:
undetectable		 3qpkA-5t00A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0u TRANSCRIPTIONAL
REPRESSOR CTCF

(Homo sapiens) 		PF00096
(zf-C2H2)
PF13909
(zf-H2C2_5) 		4 HIS A 425
CYH A 409
ILE A 411
HIS A 430
 ZN  A 505 (-3.2A)
ZN  A 505 (-2.4A)
ZN  A 505 ( 4.5A)
ZN  A 505 (-3.1A)
 1.46A 3qpkA-5t0uA:
undetectable		 3qpkA-5t0uA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulk E3 UBIQUITIN-PROTEIN
LIGASE RNF165

(Homo sapiens) 		PF13639
(zf-RING_2) 		4 CYH C 331
ILE C 333
HIS C 314
LEU C 310
 ZN  C 401 (-2.1A)
ZN  C 401 ( 4.7A)
ZN  C 401 (-3.1A)
None
 1.41A 3qpkA-5ulkC:
undetectable		 3qpkA-5ulkC:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeg TRANSCRIPTIONAL
REPRESSOR CTCF

(Homo sapiens) 		no annotation 4 HIS B 425
CYH B 409
ILE B 411
HIS B 430
 ZN  B 502 (-3.3A)
ZN  B 502 (-2.3A)
ZN  B 502 ( 4.8A)
ZN  B 502 (-3.3A)
 1.49A 3qpkA-5yegB:
undetectable		 3qpkA-5yegB:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yel TRANSCRIPTIONAL
REPRESSOR CTCF

(Homo sapiens) 		no annotation 4 HIS A 441
CYH A 439
HIS A 460
LEU A 456
 None
ZN  A 602 (-2.2A)
ZN  A 602 (-3.1A)
None
 1.39A 3qpkA-5yelA:
undetectable		 3qpkA-5yelA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Cyanidioschyzon
merolae) 		no annotation 4 HIS A 404
ILE A 407
HIS A 346
LEU A 349
 CLA  A1128 (-4.1A)
None
CLA  A1103 (-3.2A)
CLA  A1103 ( 3.6A)
 1.32A 3qpkA-6fosA:
undetectable		 3qpkA-6fosA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7paz PSEUDOAZURIN

(Alcaligenes
faecalis) 		PF00127
(Copper-bind) 		4 HIS A  40
CYH A  78
ILE A  80
HIS A  81
 CU  A 124 ( 3.1A)
CU  A 124 ( 2.1A)
CU  A 124 ( 4.3A)
CU  A 124 ( 3.2A)
 0.62A 3qpkA-7pazA:
5.9		 3qpkA-7pazA:
11.45