SIMILAR PATTERNS OF AMINO ACIDS FOR 3QOW_A_SAMA417_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amy 1,4-ALPHA-D-GLUCAN
GLUCANOHYDROLASE

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		5 GLY A 394
GLY A 307
VAL A 372
ASP A 286
PHE A 299
 None
 1.31A 3qowA-1amyA:
undetectable		 3qowA-1amyA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b74 GLUTAMATE RACEMASE

(Aquifex
pyrophilus) 		PF01177
(Asp_Glu_race) 		5 GLY A  96
GLU A  99
GLY A 110
VAL A 197
ALA A 132
 None
 1.00A 3qowA-1b74A:
2.8		 3qowA-1b74A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cq3 VIRAL CHEMOKINE
INHIBITOR

(Cowpox virus) 		PF02250
(Orthopox_35kD) 		5 GLY A 163
GLY A 196
VAL A  21
ALA A 204
ASP A 207
 None
 1.16A 3qowA-1cq3A:
undetectable		 3qowA-1cq3A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 TYR A 114
GLY A 115
GLY A 142
ALA A 400
PHE A 110
 MM4  A 784 ( 4.3A)
PGD  A 782 (-3.4A)
None
None
None
 1.24A 3qowA-1dmsA:
undetectable		 3qowA-1dmsA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		5 GLU A 301
GLY A 305
LYS A 280
ASP A 275
ASN A 303
 None
 1.30A 3qowA-1fpsA:
undetectable		 3qowA-1fpsA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 TYR A 155
GLU A 180
LYS A 175
ALA A 153
PHE A 142
 None
NDP  A 500 (-3.2A)
None
None
None
 1.17A 3qowA-1h6dA:
2.6		 3qowA-1h6dA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipf TROPINONE
REDUCTASE-II

(Datura
stramonium) 		PF13561
(adh_short_C2) 		5 TYR A  23
GLY A  24
GLU A  27
GLY A  16
VAL A  36
 None
None
None
NDP  A 261 (-3.4A)
None
 1.28A 3qowA-1ipfA:
4.5		 3qowA-1ipfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		5 TYR A 230
GLY A 285
ALA A 237
ASP A 240
PHE A 284
 None
 1.32A 3qowA-1izeA:
undetectable		 3qowA-1izeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxh ALPHA-AMYLASE

(Pseudoalteromonas
haloplanktis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 GLY A 377
VAL A 404
ALA A 397
ASP A 395
ASN A 351
 None
 1.20A 3qowA-1kxhA:
undetectable		 3qowA-1kxhA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		5 GLY A 244
GLY A 187
VAL A 184
ALA A 210
ASN A 202
 None
 1.31A 3qowA-1kyhA:
4.0		 3qowA-1kyhA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 GLU A 158
GLY A 314
VAL A 342
ALA A 165
ASP A 552
 FAD  A3000 (-4.9A)
FAD  A3000 (-3.3A)
None
FAD  A3000 (-3.3A)
None
 1.29A 3qowA-1m64A:
undetectable		 3qowA-1m64A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Thermotoga
maritima) 		PF00171
(Aldedh) 		5 GLY A 223
GLU A 221
GLY A 393
ALA A 359
PHE A 376
 None
 1.10A 3qowA-1o20A:
undetectable		 3qowA-1o20A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1m HYPOTHETICAL PROTEIN
TM0936

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		5 GLY A 164
GLU A 163
VAL A 125
ALA A 338
PHE A  52
 None
 1.28A 3qowA-1p1mA:
undetectable		 3qowA-1p1mA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvg DNA TOPOISOMERASE II

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 GLY A 122
GLU A 118
GLN A 171
ASP A  73
ASN A 150
 None
 1.31A 3qowA-1pvgA:
undetectable		 3qowA-1pvgA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpt PROSTATIC ACID
PHOSPHATASE

(Rattus
norvegicus) 		PF00328
(His_Phos_2) 		5 VAL A 331
ALA A 337
ASP A 128
PHE A 126
ASN A 233
 None
 1.29A 3qowA-1rptA:
undetectable		 3qowA-1rptA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 GLY A 511
GLU A 513
GLY A 521
ALA A 524
ASP A 559
 None
None
None
None
AMP  A 720 (-2.2A)
 1.30A 3qowA-1ry2A:
4.6		 3qowA-1ry2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY B 228
GLU B 229
GLY B 336
VAL B  11
ALA B 105
 None
 1.25A 3qowA-1tqyB:
undetectable		 3qowA-1tqyB:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2z HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Saccharomyces
cerevisiae) 		PF08123
(DOT1) 		7 TYR A 372
GLY A 373
GLU A 374
GLY A 399
PHE A 460
ASN A 479
PHE A 483
 None
SAH  A 801 (-4.2A)
None
SAH  A 801 (-3.1A)
SAH  A 801 (-3.5A)
SAH  A 801 (-4.4A)
SAH  A 801 ( 4.7A)
 0.46A 3qowA-1u2zA:
18.1		 3qowA-1u2zA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 182
GLY A 179
ALA A 219
PHE A 238
ASN A 243
 None
 1.21A 3qowA-1uufA:
6.2		 3qowA-1uufA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wr2 HYPOTHETICAL PROTEIN
PH1789

(Pyrococcus
horikoshii) 		PF13549
(ATP-grasp_5) 		5 TYR A 219
GLY A 119
VAL A 228
ALA A 189
PHE A 138
 None
 1.31A 3qowA-1wr2A:
undetectable		 3qowA-1wr2A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0u HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE ALPHA
SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01039
(Carboxyl_trans) 		5 GLY A 132
GLY A  85
VAL A  82
ALA A 123
PHE A  51
 None
 1.26A 3qowA-1x0uA:
undetectable		 3qowA-1x0uA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdp POLYPHOSPHATE KINASE

(Escherichia
coli) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		5 GLY A 601
GLU A 599
GLY A 528
VAL A 557
ASN A 524
 None
 0.88A 3qowA-1xdpA:
undetectable		 3qowA-1xdpA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydw AX110P-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01408
(GFO_IDH_MocA) 		5 GLY A 183
GLN A 340
VAL A 343
LYS A 176
PHE A 243
 None
 1.28A 3qowA-1ydwA:
3.0		 3qowA-1ydwA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk8 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus cereus) 		PF13305
(WHG) 		5 GLU A  15
GLY A  63
GLN A  11
ALA A  21
PHE A  94
 None
 1.14A 3qowA-1zk8A:
undetectable		 3qowA-1zk8A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acg PROFILIN II

(Acanthamoeba
castellanii) 		PF00235
(Profilin) 		5 GLY A  98
GLY A  79
LYS A  81
ALA A  84
PHE A  60
 None
 1.30A 3qowA-2acgA:
undetectable		 3qowA-2acgA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amy PHOSPHOMANNOMUTASE 2

(Homo sapiens) 		PF03332
(PMM) 		5 GLY A  15
GLN A  55
VAL A  52
ASP A 188
PHE A 206
 None
 1.24A 3qowA-2amyA:
undetectable		 3qowA-2amyA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE

(Podophyllum
peltatum) 		PF13561
(adh_short_C2) 		5 GLY A  27
GLU A  30
GLY A  23
ALA A  49
ASP A  72
 None
 1.30A 3qowA-2bgkA:
4.2		 3qowA-2bgkA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebj PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermus
thermophilus) 		PF01470
(Peptidase_C15) 		5 GLY A 157
GLY A  65
VAL A 185
ALA A 134
PHE A   7
 None
 1.30A 3qowA-2ebjA:
undetectable		 3qowA-2ebjA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4l ACETAMIDASE,
PUTATIVE

(Thermotoga
maritima) 		PF03069
(FmdA_AmdA) 		5 GLY A  64
GLY A 166
VAL A 200
ALA A 129
PHE A  57
 None
 1.16A 3qowA-2f4lA:
undetectable		 3qowA-2f4lA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		5 GLU A  11
GLY A  48
ALA A  99
PHE A  50
PHE A  66
 None
None
None
GOL  A2000 (-4.9A)
None
 1.18A 3qowA-2ftpA:
undetectable		 3qowA-2ftpA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 GLY A 607
GLU A 610
GLY A 493
VAL A 580
PHE A 495
 None
 1.08A 3qowA-2hpiA:
undetectable		 3qowA-2hpiA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzv UNCHARACTERIZED
PROTEIN

(Chromobacterium
violaceum) 		PF12872
(OST-HTH) 		5 GLU A  28
GLY A  33
VAL A  20
ASP A  44
PHE A  43
 None
 1.22A 3qowA-2kzvA:
undetectable		 3qowA-2kzvA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3i HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum) 		PF06032
(DUF917) 		5 GLY A  24
GLU A 300
GLY A 135
ALA A 106
ASP A 130
 None
 1.20A 3qowA-2o3iA:
undetectable		 3qowA-2o3iA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bacillus cereus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 294
GLY A 323
VAL A 133
ALA A 302
PHE A 327
 None
 1.26A 3qowA-2p88A:
undetectable		 3qowA-2p88A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1t PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE

(Bordetella
bronchiseptica) 		PF01370
(Epimerase) 		5 GLY A 195
GLU A 196
GLY A  25
ALA A 247
ASN A  53
 None
 1.06A 3qowA-2q1tA:
5.3		 3qowA-2q1tA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLY A 426
GLY A 432
VAL A 441
ALA A  62
PHE A  51
 None
 0.84A 3qowA-2q27A:
undetectable		 3qowA-2q27A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qps ALPHA-AMYLASE TYPE A
ISOZYME

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		5 GLY A 396
GLY A 309
VAL A 374
ASP A 288
PHE A 301
 None
 1.33A 3qowA-2qpsA:
undetectable		 3qowA-2qpsA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8o FLAVIVIRIN PROTEASE
NS3

(Murray Valley
encephalitis
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		5 GLY A 470
VAL A 336
LYS A 358
ALA A 420
ASP A 404
 None
 1.30A 3qowA-2v8oA:
3.2		 3qowA-2v8oA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4g MYOSIN LIGHT CHAIN
3, SKELETAL MUSCLE
ISOFORM
MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT

(Gallus gallus;
Gallus gallus) 		no annotation
PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 GLU C  85
GLY C  90
VAL M 753
ASP C  95
PHE C  94
 None
 1.25A 3qowA-2w4gC:
undetectable		 3qowA-2w4gC:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a05 TRYPTOPHANYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		5 GLY A 140
GLN A  98
VAL A 104
ALA A 363
PHE A  83
 None
 1.22A 3qowA-3a05A:
undetectable		 3qowA-3a05A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 5 GLY A 124
VAL A 265
ASP A 458
ASN A 126
PHE A  15
 None
 1.29A 3qowA-3a0fA:
undetectable		 3qowA-3a0fA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Kluyveromyces
lactis) 		PF01408
(GFO_IDH_MocA) 		5 GLY A  24
GLY A  21
ALA A  72
ASP A  86
PHE A  81
 None
 1.25A 3qowA-3e1kA:
2.1		 3qowA-3e1kA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebv CHINITASE A

(Streptomyces
coelicolor) 		PF00704
(Glyco_hydro_18) 		5 TYR A 180
GLY A 222
GLY A 267
VAL A 175
ALA A 243
 None
 1.22A 3qowA-3ebvA:
undetectable		 3qowA-3ebvA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		5 TYR A 826
GLY A 202
VAL A 185
LYS A 831
ALA A 828
 None
 1.24A 3qowA-3egwA:
3.0		 3qowA-3egwA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eiz INORGANIC
PYROPHOSPHATASE

(Burkholderia
pseudomallei) 		PF00719
(Pyrophosphatase) 		5 GLY A  57
VAL A  86
ALA A  33
ASP A  68
ASN A  55
 None
 1.14A 3qowA-3eizA:
undetectable		 3qowA-3eizA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 GLY A 133
GLY A 419
GLN A 124
LYS A 416
ALA A 414
 None
 1.24A 3qowA-3lk6A:
undetectable		 3qowA-3lk6A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9b PROBABLE
ATP-DEPENDENT DNA
LIGASE

(Pseudomonas
aeruginosa) 		PF13298
(LigD_N) 		5 TYR A  37
GLY A 111
VAL A 107
LYS A  60
ASP A  83
 None
 1.24A 3qowA-3n9bA:
undetectable		 3qowA-3n9bA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Shewanella
loihica) 		PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 TYR A 379
GLU A 193
VAL A 190
ALA A 460
ASP A 455
 None
 1.28A 3qowA-3ntdA:
2.1		 3qowA-3ntdA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		5 TYR A 104
GLY A 101
VAL A 325
ASP A 316
PHE A 318
 None
 1.27A 3qowA-3nzpA:
undetectable		 3qowA-3nzpA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0y LIPOPROTEIN

(Colwellia
psychrerythraea) 		PF05960
(DUF885) 		5 GLY A 401
GLY A 431
ALA A 500
PHE A 430
ASN A 427
 None
 0.99A 3qowA-3o0yA:
undetectable		 3qowA-3o0yA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		5 GLY A  48
GLU A  46
GLY A  87
ALA A  93
PHE A  57
 None
 1.24A 3qowA-3rmjA:
undetectable		 3qowA-3rmjA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8m ENOYL-ACP REDUCTASE

(Xanthomonas
oryzae) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		5 GLY A  54
GLY A  87
GLN A  27
VAL A  24
PHE A  73
 None
 1.23A 3qowA-3s8mA:
3.8		 3qowA-3s8mA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sft CHEMOTAXIS RESPONSE
REGULATOR
PROTEIN-GLUTAMATE
METHYLESTERASE

(Thermotoga
maritima) 		PF01339
(CheB_methylest) 		5 GLY A 220
GLU A 221
GLY A 238
ASP A 268
PHE A 265
 None
 1.33A 3qowA-3sftA:
undetectable		 3qowA-3sftA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8x TRANSFERRIN-BINDING
PROTEIN 1

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 TYR A 473
GLY A 474
GLU A 475
ALA A 124
ASP A 571
 None
C8E  A1001 (-4.3A)
None
None
None
 1.24A 3qowA-3v8xA:
undetectable		 3qowA-3v8xA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9p THYMIDYLATE KINASE

(Burkholderia
thailandensis) 		PF02223
(Thymidylate_kin) 		5 GLY A   4
VAL A  40
ASP A 101
PHE A  99
PHE A 129
 None
 1.08A 3qowA-3v9pA:
undetectable		 3qowA-3v9pA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		5 GLY A 293
GLU A 292
GLY A 296
LYS A 271
ASN A 242
 None
None
ANP  A1401 (-4.2A)
None
None
 1.29A 3qowA-3zlbA:
2.4		 3qowA-3zlbA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1

(Yersinia pestis) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		5 GLY A  54
GLY A  87
GLN A  27
VAL A  24
PHE A  73
 NA  A1402 (-3.5A)
None
None
None
None
 1.15A 3qowA-3zu4A:
4.0		 3qowA-3zu4A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		5 GLY A 115
GLY A 189
VAL A 235
ASP A 121
ASN A 157
 None
 1.26A 3qowA-3zuqA:
undetectable		 3qowA-3zuqA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acz ENDO-ALPHA-MANNOSIDA
SE

(Bacteroides
thetaiotaomicron) 		PF16317
(Glyco_hydro_99) 		5 TYR B 285
GLY B 333
GLU B 332
GLY B 282
ASP B 309
 None
 1.14A 3qowA-4aczB:
undetectable		 3qowA-4aczB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amt RENIN

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		5 TYR A  64
GLY A  65
GLU A  66
GLY A 169
ALA A 165
 None
 1.33A 3qowA-4amtA:
undetectable		 3qowA-4amtA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 5 TYR A 638
GLU A 737
GLY A 716
ALA A 649
ASP A 652
 None
 1.27A 3qowA-4btpA:
undetectable		 3qowA-4btpA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epu ANGIOPOIETIN-1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		5 GLU A 343
GLY A 446
ALA A 430
ASP A 433
PHE A 449
 None
None
None
CA  A 601 (-2.7A)
None
 1.32A 3qowA-4epuA:
undetectable		 3qowA-4epuA:
18.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4er6 HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		5 GLN A 168
ALA A 188
ASP A 222
PHE A 223
ASN A 241
 None
AW2  A 502 (-3.6A)
AW2  A 502 (-3.5A)
AW2  A 502 (-3.4A)
AW2  A 502 (-4.3A)
 0.85A 3qowA-4er6A:
40.9		 3qowA-4er6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4er6 HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		7 GLY A 163
VAL A 169
ALA A 188
ASP A 222
PHE A 223
ASN A 241
PHE A 245
 AW2  A 502 (-3.2A)
AW2  A 502 (-4.4A)
AW2  A 502 (-3.6A)
AW2  A 502 (-3.5A)
AW2  A 502 (-3.4A)
AW2  A 502 (-4.3A)
AW2  A 502 (-4.3A)
 0.40A 3qowA-4er6A:
40.9		 3qowA-4er6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4er6 HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		5 GLY A 163
VAL A 170
ALA A 188
ASP A 222
PHE A 223
 AW2  A 502 (-3.2A)
None
AW2  A 502 (-3.6A)
AW2  A 502 (-3.5A)
AW2  A 502 (-3.4A)
 1.33A 3qowA-4er6A:
40.9		 3qowA-4er6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 GLY A 344
GLU A 382
GLY A 348
LYS A 353
ALA A 354
 None
None
SO4  A 603 (-3.6A)
None
None
 1.31A 3qowA-4ga6A:
2.7		 3qowA-4ga6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3b OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Neisseria
gonorrhoeae) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		5 TYR A 609
GLY A 637
GLY A 634
ALA A 597
ASN A 684
 None
 1.21A 3qowA-4k3bA:
undetectable		 3qowA-4k3bA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 TYR A 295
GLY A 314
VAL A 290
ASP A 310
ASN A 317
 None
 1.28A 3qowA-4l7tA:
undetectable		 3qowA-4l7tA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7v DIHYDROFOLATE
REDUCTASE

(Enterococcus
faecalis) 		PF00186
(DHFR_1) 		5 GLY A  49
GLU A  48
GLY A  98
VAL A  62
PHE A 103
 None
None
NAP  A 201 (-3.2A)
None
NAP  A 201 (-4.4A)
 1.28A 3qowA-4m7vA:
undetectable		 3qowA-4m7vA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PROTEIN M TD

(Mycoplasma
genitalium) 		no annotation 5 TYR M 296
GLY M 298
VAL M 329
ALA M 248
ASN M 300
 None
 1.26A 3qowA-4nzrM:
undetectable		 3qowA-4nzrM:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		5 GLY A 355
GLN A 346
VAL A 324
LYS A 360
ALA A 361
 None
 1.29A 3qowA-4ojzA:
undetectable		 3qowA-4ojzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rye D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		5 GLY A 165
GLN A 139
ALA A  76
ASP A 118
ASN A 126
 None
 1.30A 3qowA-4ryeA:
undetectable		 3qowA-4ryeA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5u CHITINASE

(Streptomyces
thermoviolaceus) 		no annotation 5 GLY B 397
GLU B 398
GLY B 392
ALA B 387
PHE B  57
 None
 1.28A 3qowA-4w5uB:
undetectable		 3qowA-4w5uB:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 PROTEIN ATS1

(Saccharomyces
cerevisiae) 		PF00415
(RCC1) 		5 GLY B 295
GLY B 273
GLN B 311
VAL B 313
ASN B 299
 None
 1.22A 3qowA-4x33B:
undetectable		 3qowA-4x33B:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoq INTRACELLULAR SERINE
PROTEASE

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 GLY I 318
GLU I 320
GLY I 277
ASP I 335
ASN I 279
 None
 1.27A 3qowA-4zoqI:
undetectable		 3qowA-4zoqI:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 TYR A1251
GLU A1143
GLY A1138
ALA A1165
ASP A1162
 None
 1.17A 3qowA-4zxiA:
undetectable		 3qowA-4zxiA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by7 3-OXOACYL-ACP
SYNTHASE III

(Verrucosispora
maris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A   6
GLU A  16
VAL A  19
ASP A 160
PHE A 158
 None
 1.16A 3qowA-5by7A:
undetectable		 3qowA-5by7A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT
HYDRAZINE SYNTHASE
BETA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis;
Candidatus
Kuenenia
stuttgartiensis) 		no annotation
PF02239
(Cytochrom_D1) 		5 TYR A 295
GLU B 253
GLN B 258
VAL B 259
ASP A 346
 None
 1.12A 3qowA-5c2vA:
undetectable		 3qowA-5c2vA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 GLY A 477
ALA A 154
ASP A 131
ASN A 479
PHE A 643
 None
 1.33A 3qowA-5chcA:
1.7		 3qowA-5chcA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9n B-1,4-ENDOGLUCANASE

(Prevotella
bryantii) 		PF00150
(Cellulase) 		5 GLY A  65
LYS A 312
ALA A 350
ASP A 316
ASN A  67
 None
 1.20A 3qowA-5d9nA:
undetectable		 3qowA-5d9nA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dnw SHKAI2IB

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		5 GLU A 173
GLY A  27
VAL A  32
PHE A  26
PHE A 157
 None
 1.32A 3qowA-5dnwA:
2.1		 3qowA-5dnwA:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		8 GLY A 163
VAL A 169
LYS A 187
ALA A 188
ASP A 222
PHE A 223
ASN A 241
PHE A 245
 None
None
None
None
None
None
5F7  A 401 (-3.6A)
None
 0.55A 3qowA-5dtrA:
39.1		 3qowA-5dtrA:
92.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		6 GLY A 163
VAL A 170
LYS A 187
ALA A 188
ASP A 222
PHE A 223
 None
 1.28A 3qowA-5dtrA:
39.1		 3qowA-5dtrA:
92.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghs SSDNA-SPECIFIC
EXONUCLEASE

(Thermococcus
kodakarensis) 		PF02272
(DHHA1) 		5 GLY A 435
GLU A 436
GLY A 407
ALA A 444
PHE A 456
 None
 1.22A 3qowA-5ghsA:
2.1		 3qowA-5ghsA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkk PUTATIVE HOMING
ENDONUCLEASE

(Thermotoga
neapolitana) 		PF00961
(LAGLIDADG_1) 		5 GLY A  14
GLU A  15
GLN A  42
VAL A  49
PHE A  86
 None
 1.32A 3qowA-5gkkA:
undetectable		 3qowA-5gkkA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hon EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF13385
(Laminin_G_3) 		5 GLY A 754
GLY A 730
ASP A 702
PHE A 810
PHE A 803
 None
 1.21A 3qowA-5honA:
undetectable		 3qowA-5honA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp6 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF13385
(Laminin_G_3)
PF16369
(GH43_C) 		5 GLY A 754
GLY A 730
ASP A 702
PHE A 810
PHE A 803
 None
 1.25A 3qowA-5hp6A:
undetectable		 3qowA-5hp6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 187
GLU A 201
VAL A 205
PHE A 267
ASN A 198
 None
 1.16A 3qowA-5jp0A:
undetectable		 3qowA-5jp0A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA

(Mus musculus) 		PF01532
(Glyco_hydro_47) 		5 GLY A 289
GLY A 311
ASP A 368
ASN A 284
PHE A 359
 None
 1.31A 3qowA-5kkbA:
undetectable		 3qowA-5kkbA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 5 GLY A 105
GLU A 106
GLY A  69
ALA A 692
ASN A  62
 None
 1.21A 3qowA-5mzsA:
undetectable		 3qowA-5mzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT

(Homo sapiens) 		no annotation 5 TYR A 655
GLY A 631
GLY A 518
ASN A 638
PHE A 663
 None
 1.14A 3qowA-5nprA:
2.9		 3qowA-5nprA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 GLU A  13
GLN A  22
VAL A  19
ALA A 169
PHE A 235
 None
 1.10A 3qowA-5t8tA:
undetectable		 3qowA-5t8tA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttk AMINE OXIDASE

(Pseudomonas
putida) 		PF01593
(Amino_oxidase) 		5 GLY A 446
GLY A 302
VAL A 477
LYS A 290
PHE A  52
 None
 1.30A 3qowA-5ttkA:
1.6		 3qowA-5ttkA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veg FLAVODOXIN

(Lactobacillus
reuteri) 		no annotation 5 TYR A  85
VAL A 103
ALA A 113
PHE A  71
PHE A  46
 None
 1.30A 3qowA-5vegA:
2.5		 3qowA-5vegA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqj EXO-BETA-1,4-XYLANAS
E

(unidentified) 		no annotation 5 TYR A 126
GLN A 103
LYS A 171
ALA A 172
ASN A 122
 None
 1.23A 3qowA-5vqjA:
undetectable		 3qowA-5vqjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8t PROTEIN L3

(Spinacia
oleracea) 		PF00297
(Ribosomal_L3) 		5 GLY D  91
VAL D 123
ALA D  88
ASP D 198
PHE D 191
 None
 1.29A 3qowA-5x8tD:
undetectable		 3qowA-5x8tD:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccu GLUCOSE-INDUCED
DEGRADATION PROTEIN
4 HOMOLOG

(Homo sapiens) 		no annotation 5 TYR A 272
GLY A 271
GLU A 270
ASP A 194
PHE A 257
 None
 1.27A 3qowA-6ccuA:
undetectable		 3qowA-6ccuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdw EFFECTOR PROTEIN
LEM4 (LPG1101)

(Legionella
pneumophila) 		no annotation 5 GLY A 162
GLY A 168
VAL A 178
LYS A 136
ALA A 137
 None
 1.26A 3qowA-6cdwA:
undetectable		 3qowA-6cdwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 5 TYR A 196
GLY A 169
VAL A 187
PHE A 202
PHE A 227
 SO4  A 503 (-4.5A)
None
None
None
None
 1.19A 3qowA-6czxA:
2.1		 3qowA-6czxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 5 GLY A2186
GLY A2211
VAL A2205
ALA A1936
ASP A1956
 None
 1.19A 3qowA-6fb3A:
undetectable		 3qowA-6fb3A:
undetectable